| Year |
Citation |
Score |
| 2023 |
Roecker AJ, Schirripa KM, Loughran HM, Tong L, Liang T, Fillgrove KL, Kuo Y, Bleasby K, Collier H, Altman MD, Ford MC, Drolet RE, Cosden M, Jinn S, Hatcher NG, et al. Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease. Acs Medicinal Chemistry Letters. 14: 146-155. PMID 36793422 DOI: 10.1021/acsmedchemlett.2c00441 |
0.417 |
|
| 2021 |
Cosden M, Jinn S, Yao L, Gretzula CA, Kandebo M, Toolan D, Hatcher NG, Ma L, Lemaire W, Adam GC, Burlein C, Minnick C, Flick R, Watt ML, Mulhearn J, ... ... Drolet RE, et al. A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy. Neurobiology of Disease. 105507. PMID 34509608 DOI: 10.1016/j.nbd.2021.105507 |
0.457 |
|
| 2021 |
Polinski NK, Martinez TN, Gorodinsky A, Gareus R, Sasner M, Herberth M, Switzer R, Ahmad SO, Cosden M, Kandebo M, Drolet RE, Buckett PD, Shan W, Chen Y, Pellegrino LJ, et al. Decreased glucocerebrosidase activity and substrate accumulation of glycosphingolipids in a novel GBA1 D409V knock-in mouse model. Plos One. 16: e0252325. PMID 34106956 DOI: 10.1371/journal.pone.0252325 |
0.686 |
|
| 2019 |
Rocha EM, De Miranda BR, Castro S, Drolet R, Hatcher NG, Yao L, Smith SM, Keeney MT, Di Maio R, Kofler J, Hastings TG, Greenamyre JT. LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease. Neurobiology of Disease. 104626. PMID 31618685 DOI: 10.1016/J.Nbd.2019.104626 |
0.649 |
|
| 2019 |
Jinn S, Blauwendraat C, Toolan D, Gretzula CA, Drolet RE, Smith S, Nalls MA, Marcus J, Singleton AB, Stone DJ. Functionalization of the TMEM175 p.M393T Variant as a risk factor for Parkinson Disease. Human Molecular Genetics. PMID 31261387 DOI: 10.1093/Hmg/Ddz136 |
0.394 |
|
| 2017 |
Jinn S, Drolet RE, Cramer PE, Wong AH, Toolan DM, Gretzula CA, Voleti B, Vassileva G, Disa J, Tadin-Strapps M, Stone DJ. TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation. Proceedings of the National Academy of Sciences of the United States of America. PMID 28193887 DOI: 10.1073/Pnas.1616332114 |
0.553 |
|
| 2014 |
Farrell KF, Krishnamachari S, Villanueva E, Lou H, Alerte TN, Peet E, Drolet RE, Perez RG. Non-motor parkinsonian pathology in aging A53T α-synuclein mice is associated with progressive synucleinopathy and altered enzymatic function. Journal of Neurochemistry. 128: 536-46. PMID 24117685 DOI: 10.1111/jnc.12481 |
0.463 |
|
| 2010 |
Greenamyre JT, Cannon JR, Drolet R, Mastroberardino PG. Lessons from the rotenone model of Parkinson's disease. Trends in Pharmacological Sciences. 31: 141-2; author reply . PMID 20096940 DOI: 10.1016/J.Tips.2009.12.006 |
0.666 |
|
| 2009 |
Drolet RE, Cannon JR, Montero L, Greenamyre JT. Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology. Neurobiology of Disease. 36: 96-102. PMID 19595768 DOI: 10.1016/J.Nbd.2009.06.017 |
0.701 |
|
| 2009 |
Cannon JR, Tapias V, Na HM, Honick AS, Drolet RE, Greenamyre JT. A highly reproducible rotenone model of Parkinson's disease. Neurobiology of Disease. 34: 279-90. PMID 19385059 DOI: 10.1016/J.Nbd.2009.01.016 |
0.723 |
|
| 2009 |
Drolet RE, Cannon JR, Montero LM, Greenamyre JT. T1782 Rotenone Recapitulates Parkinson's Disease-Related Gastrointestinal Motility Deficits and Alpha-Synuclein Pathology in the Enteric Nervous System Gastroenterology. 136: A-578-A-579. DOI: 10.1016/S0016-5085(09)62663-9 |
0.633 |
|
| 2008 |
Janis KL, Brennan RT, Drolet RE, Behrouz B, Kaufman SK, Lookingland KJ, Goudreau JL. Effects of sildenafil on nigrostriatal dopamine neurons in a murine model of Parkinson's disease. Journal of Alzheimer's Disease : Jad. 15: 97-107. PMID 18780970 DOI: 10.3233/Jad-2008-15108 |
0.373 |
|
| 2007 |
Behrouz B, Drolet RE, Sayed ZA, Lookingland KJ, Goudreau JL. Unique responses to mitochondrial complex I inhibition in tuberoinfundibular dopamine neurons may impart resistance to toxic insult. Neuroscience. 147: 592-8. PMID 17583437 DOI: 10.1016/J.Neuroscience.2007.05.007 |
0.376 |
|
| 2006 |
Duka T, Rusnak M, Drolet RE, Duka V, Wersinger C, Goudreau JL, Sidhu A. Alpha-synuclein induces hyperphosphorylation of Tau in the MPTP model of parkinsonism. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 2302-12. PMID 17077307 DOI: 10.1096/Fj.06-6092Com |
0.41 |
|
| 2004 |
Drolet RE, Behrouz B, Lookingland KJ, Goudreau JL. Mice lacking alpha-synuclein have an attenuated loss of striatal dopamine following prolonged chronic MPTP administration. Neurotoxicology. 25: 761-9. PMID 15288507 DOI: 10.1016/J.Neuro.2004.05.002 |
0.36 |
|
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