Robert Drolet, PhD - Related publications

Affiliations: 
Merck, Semoy, Centre-Val de Loire, France 
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Hsu YL, Hung HS, Tsai CW, Liu SP, Chiang YT, Kuo YH, Shyu WC, Lin SZ, Fu RH. Peiminine Reduces ARTS-Mediated Degradation of XIAP by Modulating the PINK1/Parkin Pathway to Ameliorate 6-Hydroxydopamine Toxicity and α-Synuclein Accumulation in Parkinson's Disease Models In Vivo and In Vitro. International Journal of Molecular Sciences. 22. PMID 34638579 DOI: 10.3390/ijms221910240   
2021 Kang B, Li N, Liu S, Qi S, Mu S. Protective Effect of Isopulegol in Alleviating Neuroinflammation in Lipopolysaccharide-Induced BV-2 Cells and in Parkinson Disease Model Induced with MPTP. Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society For Environmental Toxicology and Cancer. 40: 75-85. PMID 34587406 DOI: 10.1615/JEnvironPatholToxicolOncol.2021038944   
2021 Tian Y, He M, Pan L, Yuan X, Xiong M, Meng L, Yao Z, Yu Z, Ye K, Zhang Z. Transgenic Mice Expressing Human α-Synuclein 1-103 Fragment as a Novel Model of Parkinson's Disease. Frontiers in Aging Neuroscience. 13: 760781. PMID 34744697 DOI: 10.3389/fnagi.2021.760781   
2021 Ferrer-Lorente R, Lozano-Cruz T, Fernández-Carasa I, Miłowska K, de la Mata FJ, Bryszewska M, Consiglio A, Ortega P, Gómez R, Raya A. Cationic Carbosilane Dendrimers Prevent Abnormal α-Synuclein Accumulation in Parkinson's Disease Patient-Specific Dopamine Neurons. Biomacromolecules. 22: 4582-4591. PMID 34613701 DOI: 10.1021/acs.biomac.1c00884   
2021 Mirzaei S, Kulkarni K, Zhou K, Crack PJ, Aguilar MI, Finkelstein DI, Forsythe JS. Biomaterial Strategies for Restorative Therapies in Parkinson's Disease. Acs Chemical Neuroscience. PMID 34634903 DOI: 10.1021/acschemneuro.1c00484   
2021 Soner BC, Acikgoz E, Inan SY, Ayla S, Sahin AS, Oktem G. Neuroprotective Effect of Intrastriatal Caffeic Acid Phenethyl Ester Treatment in 6-OH Dopamine Model of Parkinson's Disease in Rats. Parkinson's Disease. 2021: 5553480. PMID 34512945 DOI: 10.1155/2021/5553480   
2021 Kim AR, Pavlova EN, Blokhin VE, Bogdanov VV, Ugrumov MV. A Monoiodotyrosine Challenge Test in a Parkinson's Disease Model. Acta Naturae. 13: 106-109. PMID 34707902 DOI: 10.32607/actanaturae.11399   
2021 Hang L, Wang Z, Foo ASC, Goh GWY, Choong HC, Thundyil J, Xu S, Lam KP, Lim KL. Conditional disruption of AMP kinase in dopaminergic neurons promotes Parkinson's disease-associated phenotypes in vivo. Neurobiology of Disease. 161: 105560. PMID 34767944 DOI: 10.1016/j.nbd.2021.105560   
2021 Toyoshima Y, Takahashi H, Katada S, Kojima N, Tada M, Tani T, Koike R, Nozawa T, Aida I, Nakajima T, Onodera O, Kakita A. Parkinson's disease and parkinsonism: Clinicopathological discrepancies on diagnosis in three patients. Neuropathology : Official Journal of the Japanese Society of Neuropathology. PMID 34779072 DOI: 10.1111/neup.12777   
2021 de Rus Jacquet A, Ambaw A, Tambe MA, Ma SY, Timmers M, Grace MH, Wu QL, Simon JE, McCabe GP, Lila MA, Shi R, Rochet JC. Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson's disease models. Food & Function. PMID 34751296 DOI: 10.1039/d1fo00007a   
2021 Zhou Z, Ye P, Li XH, Zhang Y, Li M, Chen QY, Lu JS, Xue M, Li Y, Liu W, Lu L, Shi W, Xu PY, Zhuo M. Synaptic potentiation of anterior cingulate cortex contributes to chronic pain of Parkinson's disease. Molecular Brain. 14: 161. PMID 34742316 DOI: 10.1186/s13041-021-00870-y   
2021 Isenbrandt A, Morissette M, Bourque M, Lamontagne-Proulx J, Coulombe K, Soulet D, Di Paolo T. Effect of sex and gonadectomy on brain MPTP toxicity and response to dutasteride treatment in mice. Neuropharmacology. 201: 108784. PMID 34555366 DOI: 10.1016/j.neuropharm.2021.108784   
2021 Christmann A, Gries M, Scholz P, Stahr PL, Law JKY, Schulte S, Martin M, Lilischkis R, Ingebrandt S, Keck CM, Schäfer KH. The antioxidant Rutin counteracts the pathological impact of -synuclein on the enteric nervous system . Biological Chemistry. PMID 34582634 DOI: 10.1515/hsz-2021-0259   
2021 David FJ, Munoz MJ, Shils JL, Pauciulo MW, Hale PT, Nichols WC, Afshari M, Sani S, Verhagen Metman L, Corcos DM, Pal GD. Subthalamic Peak Beta Ratio Is Asymmetric in Glucocerebrosidase Mutation Carriers With Parkinson's Disease: A Pilot Study. Frontiers in Neurology. 12: 723476. PMID 34659089 DOI: 10.3389/fneur.2021.723476   
2021 Chetia Phukan B, Dutta A, Deb S, Saikia R, Mazumder MK, Paul R, Bhattacharya P, Sandhir R, Borah A. Garcinol blocks motor behavioural deficits by providing dopaminergic neuroprotection in MPTP mouse model of Parkinson's disease: involvement of anti-inflammatory response. Experimental Brain Research. PMID 34633467 DOI: 10.1007/s00221-021-06237-y   
2021 Pediaditakis I, Kodella KR, Manatakis DV, Le CY, Hinojosa CD, Tien-Street W, Manolakos ES, Vekrellis K, Hamilton GA, Ewart L, Rubin LL, Karalis K. Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption. Nature Communications. 12: 5907. PMID 34625559 DOI: 10.1038/s41467-021-26066-5   
2021 Karimi A, Elmi M, Shiri Z, Baharvand H. Therapeutic potential of pluripotent stem cell-derived dopaminergic progenitors in Parkinson's disease: a systematic review protocol. Systematic Reviews. 10: 188. PMID 34172098 DOI: 10.1186/s13643-021-01736-z   
2021 Nimmo JT, Smith H, Wang CY, Teeling JL, Nicoll JAR, Verma A, Dodart JC, Liu Z, Lin F, Carare RO. Immunisation with UB-312 in the Thy1SNCA mouse prevents motor performance deficits and oligomeric α-synuclein accumulation in the brain and gut. Acta Neuropathologica. PMID 34741635 DOI: 10.1007/s00401-021-02381-5   
2021 Kwon SH, Kim S, Park AY, Lee S, Gadhe CG, Seo BA, Park JS, Jo S, Oh Y, Kweon SH, Ma SX, Kim WR, Kim M, Kim H, Kim JE, et al. A Novel, Selective c-Abl Inhibitor, Compound 5, Prevents Neurodegeneration in Parkinson's Disease. Journal of Medicinal Chemistry. PMID 34583507 DOI: 10.1021/acs.jmedchem.1c01022   
2021 Caulfield ME, Stancati JA, Steece-Collier K. Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease. Journal of Visualized Experiments : Jove. PMID 34723950 DOI: 10.3791/62970   
2021 Johnson AM, Ou ZA, Gordon R, Saminathan H. Environmental neurotoxicants and inflammasome activation in Parkinson's disease - a focus on the gut-brain axis. The International Journal of Biochemistry & Cell Biology. 106113. PMID 34737076 DOI: 10.1016/j.biocel.2021.106113   
2021 Cai P, Zheng Y, Sun Y, Zhang C, Zhang Q, Liu Q. New Blood-Brain Barrier Models Using Primary Parkinson's Disease Rat Brain Endothelial Cells and Astrocytes for the Development of Central Nervous System Drug Delivery Systems. Acs Chemical Neuroscience. PMID 34623131 DOI: 10.1021/acschemneuro.1c00118   
2021 Cai HY, Fu XX, Jiang H, Han S. Adjusting vascular permeability, leukocyte infiltration, and microglial cell activation to rescue dopaminergic neurons in rodent models of Parkinson's disease. Npj Parkinson's Disease. 7: 91. PMID 34625569 DOI: 10.1038/s41531-021-00233-3   
2021 Cuenca-Bermejo L, Pizzichini E, Gonçalves VC, Guillén-Díaz M, Aguilar-Moñino E, Sánchez-Rodrigo C, González-Cuello AM, Fernández-Villalba E, Herrero MT. A New Tool to Study Parkinsonism in the Context of Aging: MPTP Intoxication in a Natural Model of Multimorbidity. International Journal of Molecular Sciences. 22. PMID 33919373 DOI: 10.3390/ijms22094341   
2021 Lan G, Wang P, Chan RB, Liu Z, Yu Z, Liu X, Yang Y, Zhang J. Astrocytic VEGFA: An essential mediator in blood-brain-barrier disruption in Parkinson's disease. Glia. PMID 34713920 DOI: 10.1002/glia.24109   
2021 Lima IS, Pêgo AC, Barros JT, Prada AR, Gozzelino R. Cell Death-Osis of Dopaminergic Neurons and the Role of Iron in Parkinson's Disease. Antioxidants & Redox Signaling. 35: 453-473. PMID 33233941 DOI: 10.1089/ars.2020.8229   
2021 Hsiao IT, Chang YT, Weng YH, Hsu SW, Lin KJ, Lu CS, Chang CC. Comparisons of vesicular monoamine transporter type 2 signals in Parkinson's disease and Parkinsonism secondary to carbon monoxide poisoning. Neurotoxicology. PMID 34774656 DOI: 10.1016/j.neuro.2021.11.004   
2021 Curtis JA, Dakin AE, Troche MS. Effects of Bolus Holding on Respiratory-Swallow Coordination in Parkinson's Disease. American Journal of Speech-Language Pathology. 1-17. PMID 34752144 DOI: 10.1044/2021_AJSLP-21-00044   
2021 Zhang X, Chen W, Wu Y, Zeng W, Yuan Y, Cheng C, Yang X, Wang J, Yang X, Xu Y, Lei H, Cao X, Xu Y. Histological Correlates of Neuroanatomical Changes in a Rat Model of Levodopa-Induced Dyskinesia Based on Voxel-Based Morphometry. Frontiers in Aging Neuroscience. 13: 759934. PMID 34776935 DOI: 10.3389/fnagi.2021.759934   
2021 Ahmad MH, Fatima M, Ali M, Rizvi MA, Chandra Mondal A. Naringenin alleviates paraquat-induced dopaminergic neuronal loss in SH-SY5Y cells and a rat model of Parkinson's disease. Neuropharmacology. 108831. PMID 34655599 DOI: 10.1016/j.neuropharm.2021.108831   
2021 Burbulla LF, Zheng J, Song P, Jiang W, Johnson ME, Brundin P, Krainc D. Direct targeting of wild-type glucocerebrosidase by antipsychotic quetiapine improves pathogenic phenotypes in Parkinson's disease models. Jci Insight. 6. PMID 34622801 DOI: 10.1172/jci.insight.148649   
2021 González-Rodríguez P, Zampese E, Stout KA, Guzman JN, Ilijic E, Yang B, Tkatch T, Stavarache MA, Wokosin DL, Gao L, Kaplitt MG, López-Barneo J, Schumacker PT, Surmeier DJ. Disruption of mitochondrial complex I induces progressive parkinsonism. Nature. PMID 34732887 DOI: 10.1038/s41586-021-04059-0   
2021 Oh T, Daadi ES, Kim J, Daadi EW, Chen PJ, Roy-Choudhury G, Bohmann J, Blass BE, Daadi MM. Dopamine D3 receptor ligand suppresses the expression of levodopa-induced dyskinesia in nonhuman primate model of parkinson's disease. Experimental Neurology. 113920. PMID 34762921 DOI: 10.1016/j.expneurol.2021.113920   
2021 Madiha S, Batool Z, Tabassum S, Liaquat L, Sadir S, Shahzad S, Naqvi F, Saleem S, Yousuf S, Nawaz A, Ahmad S, Sajid I, Afzal A, Haider S. Quercetin exhibits potent antioxidant activity, restores motor and non-motor deficits induced by rotenone toxicity. Plos One. 16: e0258928. PMID 34767546 DOI: 10.1371/journal.pone.0258928   
2021 Kim Y, Kim I, Sung JM, Song J. Parkinson's disease in a worker exposed to insecticides at a greenhouse. Annals of Occupational and Environmental Medicine. 33: e6. PMID 34754467 DOI: 10.35371/aoem.2021.33.e6   
2021 Nam MH, Park JH, Song HJ, Choi JW, Kim S, Jang BK, Yoon HH, Heo JY, Lee H, An H, Kim HJ, Park SJ, Cho DW, Yang YS, Han SC, et al. KDS2010, a Newly Developed Reversible MAO-B Inhibitor, as an Effective Therapeutic Candidate for Parkinson's Disease. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 34611843 DOI: 10.1007/s13311-021-01097-4   
2021 Zhang C, Zhao M, Wang B, Su Z, Guo B, Qin L, Zhang W, Zheng R. The Nrf2-NLRP3-caspase-1 axis mediates the neuroprotective effects of Celastrol in Parkinson's disease. Redox Biology. 47: 102134. PMID 34600334 DOI: 10.1016/j.redox.2021.102134   
2021 Kaiser M, Dahl J, Jacobsen S, Jacobson M, Andersen PH, Bækbo P, Escribano D, Cerón JJ, Tecles F. Changes of adenosine deaminase activity in serum and saliva around parturition in sows with and without postpartum dysgalactia syndrome. Bmc Veterinary Research. 17: 352. PMID 34794425 DOI: 10.1186/s12917-021-03067-6   
2021 Sawyer TW, Wang Y, Villanueva M, Song Y, Hennes G. Acute and long-term effects of VX in rat brain cell aggregate culture. Toxicology in Vitro : An International Journal Published in Association With Bibra. 105256. PMID 34653647 DOI: 10.1016/j.tiv.2021.105256   
2021 Brzozowski CF, Hijaz BA, Singh V, Gcwensa NZ, Kelly K, Boyden ES, West AB, Sarkar D, Volpicelli-Daley LA. Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein. Acta Neuropathologica Communications. 9: 180. PMID 34749824 DOI: 10.1186/s40478-021-01283-7   
2021 Zhao Z, Li F, Ning J, Peng R, Shang J, Liu H, Shang M, Bao XQ, Zhang D. Novel compound FLZ alleviates rotenone-induced PD mouse model by suppressing TLR4/MyD88/NF-B pathway through microbiota-gut-brain axis. Acta Pharmaceutica Sinica. B. 11: 2859-2879. PMID 34589401 DOI: 10.1016/j.apsb.2021.03.020   
2021 Kang S, Piao Y, Kang YC, Lim S, Pak YK. DA-9805 protects dopaminergic neurons from endoplasmic reticulum stress and inflammation. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 145: 112389. PMID 34775235 DOI: 10.1016/j.biopha.2021.112389   
2021 Ninkina N, Millership SJ, Peters OM, Connor-Robson N, Chaprov K, Kopylov AT, Montoya A, Kramer H, Withers DJ, Buchman VL. β-synuclein potentiates synaptic vesicle dopamine uptake and rescues dopaminergic neurons from MPTP-induced death in the absence of other synucleins. The Journal of Biological Chemistry. 101375. PMID 34736896 DOI: 10.1016/j.jbc.2021.101375   
2021 Yoon SY, Suh JH, Yang SN, Han K, Kim YW. Association of Physical Activity, Including Amount and Maintenance, With All-Cause Mortality in Parkinson Disease. Jama Neurology. PMID 34724534 DOI: 10.1001/jamaneurol.2021.3926   
2021 Lin YE, Lin CH, Ho EP, Ke YC, Petridi S, Elliott CJ, Sheen LY, Chien CT. Glial Nrf2 signaling mediates the neuroprotection exerted by Blume in Lrrk2-G2019S Parkinson's disease. Elife. 10. PMID 34779396 DOI: 10.7554/eLife.73753   
2021 Molska GR, Paula-Freire LIG, Sakalem ME, Köhn DO, Negri G, Carlini EA, Mendes FR. Green coffee extract attenuates Parkinson's-related behaviors in animal models. Anais Da Academia Brasileira De Ciencias. 93: e20210481. PMID 34730624 DOI: 10.1590/0001-3765202120210481   
2021 Yan Y, Chen Y, Liu Z, Cai F, Niu W, Song L, Liang H, Su Z, Yu B, Yan F. Brain Delivery of Curcumin Through Low-Intensity Ultrasound-Induced Blood-Brain Barrier Opening via Lipid-PLGA Nanobubbles. International Journal of Nanomedicine. 16: 7433-7447. PMID 34764649 DOI: 10.2147/IJN.S327737   
2021 Xu H, Zhong Y, Yuan S, Wu Y, Ma Z, Hao Z, Ding H, Wu H, Liu G, Pang M, Liu N, Wang C, Zhang N. Nitric Oxide Synthase Type 1 Methylation Is Associated With White Matter Microstructure in the Corpus Callosum and Greater Panic Disorder Severity Among Panic Disorder Patients. Frontiers in Neurology. 12: 755270. PMID 34733233 DOI: 10.3389/fneur.2021.755270   
2021 Higgins AL, Toffoli M, Mullin S, Lee CY, Koletsi S, Avenali M, Blandini F, Schapira AH. The remote assessment of parkinsonism supporting ongoing development of interventions in Gaucher disease. Neurodegenerative Disease Management. PMID 34666501 DOI: 10.2217/nmt-2021-0032   
2021 Orso B, Arnaldi D, Girtler N, Brugnolo A, Doglione E, Mattioli P, Biassoni E, Fancellu R, Massa F, Bauckneht M, Chiola S, Morbelli S, Nobili F, Pardini M. Dopaminergic and Serotonergic Degeneration and Cortical [ F]Fluorodeoxyglucose Positron Emission Tomography in De Novo Parkinson's Disease. Movement Disorders : Official Journal of the Movement Disorder Society. 36: 2293-2302. PMID 34021923 DOI: 10.1002/mds.28654