Antti Pertovaara - Publications

Affiliations: 
Physiology University of Helsinki, Helsingfors, Finland 

228 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Wei H, Ailanen L, Morales M, Koivisto A, Pertovaara A. Spinal TRPA1 Contributes to the Mechanical Hypersensitivity Effect Induced by Netrin-1. International Journal of Molecular Sciences. 23. PMID 35743067 DOI: 10.3390/ijms23126629  0.389
2022 You HJ, Lei J, Pertovaara A. Thalamus: The 'promoter' of endogenous modulation of pain and potential therapeutic target in pathological pain. Neuroscience and Biobehavioral Reviews. 139: 104745. PMID 35716873 DOI: 10.1016/j.neubiorev.2022.104745  0.374
2021 Llorca-Torralba M, Camarena-Delgado C, Suárez-Pereira I, Bravo L, Mariscal P, Garcia-Partida JA, López-Martín C, Wei H, Pertovaara A, Mico JA, Berrocoso E. Pain and depression comorbidity causes asymmetric plasticity in the locus coeruleus neurons. Brain : a Journal of Neurology. PMID 34373893 DOI: 10.1093/brain/awab239  0.356
2021 Wei H, Chen Z, Koivisto A, Pertovaara A. Spinal mechanisms contributing to the development of pain hypersensitivity induced by sphingolipids in the rat. Pharmacological Reports : Pr. PMID 33389723 DOI: 10.1007/s43440-020-00207-x  0.399
2020 Viisanen H, Lilius TO, Sagalajev B, Rauhala P, Kalso E, Pertovaara A. Neurophysiological response properties of medullary pain-control neurons following chronic treatment with morphine or oxycodone: modulation by acute ketamine. Journal of Neurophysiology. 124: 790-801. PMID 32755331 DOI: 10.1152/Jn.00343.2020  0.369
2020 Lei J, Ye G, Pertovaara A, You HJ. Effects of heating-needle stimulation in restoration of weakened descending inhibition of nociception in a rat model of Parkinson's disease. Neuroscience. PMID 32504795 DOI: 10.1016/J.Neuroscience.2020.05.043  0.303
2020 Lei J, Ye G, Pertovaara A, You HJ. Effects of intramuscular heating-needle stimulation in controlling adjuvant-induced muscle nociception in rats: differential roles of purinergic P2X3 receptors. Neuroscience. PMID 32147510 DOI: 10.1016/J.Neuroscience.2020.02.039  0.353
2019 Gao Z, Wei H, Chen Z, Jalava N, Koivisto A, Pertovaara A. Ongoing pain in streptozotocin model of diabetes in the rat: correlation with cutaneous cheminociception. Journal of Physiology and Pharmacology : An Official Journal of the Polish Physiological Society. 70. PMID 32203940 DOI: 10.26402/Jpp.2019.6.14  0.415
2018 Chen Z, Wei H, Sagalajev B, Koivisto A, Pertovaara A. Amygdaloid administration of tetrapentylammonium attenuates development of pain and anxiety-like behavior following peripheral nerve injury. Pharmacological Reports : Pr. 71: 54-60. PMID 30465925 DOI: 10.1016/J.Pharep.2018.08.005  0.481
2018 Koivisto A, Jalava N, Bratty R, Pertovaara A. TRPA1 Antagonists for Pain Relief. Pharmaceuticals (Basel, Switzerland). 11. PMID 30388732 DOI: 10.3390/Ph11040117  0.51
2018 Martikainen IK, Hagelberg N, Jääskeläinen SK, Hietala J, Pertovaara A. Dopaminergic and serotonergic mechanisms in the modulation of pain: In vivo studies in human brain. European Journal of Pharmacology. 834: 337-345. PMID 30036531 DOI: 10.1016/J.Ejphar.2018.07.038  0.403
2018 Bourbia N, Pertovaara A. Is finding the common biological link(s) between pain and affect an infinity quest? Scandinavian Journal of Pain. 2: 137-138. PMID 29913739 DOI: 10.1016/J.Sjpain.2011.05.001  0.782
2018 Bourbia N, Pertovaara A. Involvement of the periaqueductal gray in the descending antinociceptive effect induced by the central nucleus of amygdala. Physiological Research. 67: 647-655. PMID 29750883 DOI: 10.33549/Physiolres.933699  0.78
2018 Chen Z, Wei H, Pertovaara A, Wang J, Carlson S. Anxiety- and activity-related effects of paracetamol on healthy and neuropathic rats. Pharmacology Research & Perspectives. 6. PMID 29417759 DOI: 10.1002/Prp2.367  0.413
2017 Wei H, Huang JL, Hao B, Wang YC, Nian G, Ma AN, Li XY, Wang YX, Pertovaara A. Intrathecal administration of antioxidants attenuates mechanical pain hypersensitivity induced by REM sleep deprivation in the rat. Scandinavian Journal of Pain. 2: 64-69. PMID 29913726 DOI: 10.1016/J.Sjpain.2011.01.001  0.458
2017 Jin CY, Wei H, Karlstedt K, Pertovaara A. Histamine in the locus coeruleus attenuates neuropathic hypersensitivity. Scandinavian Journal of Pain. 4: 259-260. PMID 29913648 DOI: 10.1016/J.Sjpain.2013.07.015  0.487
2017 Viisanen H, Lasierra M, Wei H, Koivisto A, Åkerman KE, Pertovaara A. Pronociceptive effects of a TRPA1 channel agonist methylglyoxal in healthy control and diabetic animals. Scandinavian Journal of Pain. 4: 260. PMID 29913630 DOI: 10.1016/J.Sjpain.2013.07.016  0.425
2017 Sagalajev B, Wei H, Chen Z, Albayrak I, Koivisto A, Pertovaara A. Oxidative stress in the amygdala contributes to neuropathic pain. Neuroscience. PMID 29274353 DOI: 10.1016/J.Neuroscience.2017.12.009  0.524
2017 Pertovaara A. Multi-target treatment of bone cancer pain using synergistic combinations of pharmacological compounds in experimental animals. Scandinavian Journal of Pain. 14: 69-70. PMID 28850433 DOI: 10.1016/J.Sjpain.2016.11.001  0.341
2017 Lei J, Ye G, Wu JT, Pertovaara A, You HJ. Role of capsaicin- and heat-sensitive afferents in stimulation of acupoint induced pain and analgesia in humans. Neuroscience. PMID 28684276 DOI: 10.1016/J.Neuroscience.2017.06.051  0.474
2017 Lamusuo S, Hirvonen J, Lindholm P, Martikainen IK, Hagelberg N, Parkkola R, Taiminen T, Hietala J, Helin S, Virtanen A, Pertovaara A, Jääskeläinen SK. Neurotransmitters behind pain relief with transcranial magnetic stimulation - positron emission tomography evidence for release of endogenous opioids. European Journal of Pain. 21: 1505-1515. PMID 28493519 DOI: 10.1002/Ejp.1052  0.438
2017 David-Pereira A, Sagalajev B, Wei H, Almeida A, Pertovaara A, Pinto-Ribeiro F. The medullary dorsal reticular nucleus as a relay for descending pronociception induced by the mGluR5 in the rat infralimbic cortex. Neuroscience. PMID 28300633 DOI: 10.1016/J.Neuroscience.2017.02.046  0.403
2017 Amorim D, Puga S, Bragança R, Braga A, Pertovaara A, Almeida A, Pinto-Ribeiro F. Minocycline reduces mechanical allodynia and depressive-like behaviour in type-1 diabetes mellitus in the rat. Behavioural Brain Research. 327: 1-10. PMID 28286285 DOI: 10.1016/J.Bbr.2017.03.003  0.412
2017 Sagalajev B, Viisanen H, Wei H, Pertovaara A. Descending antinociception induced by secondary somatosensory cortex stimulation in experimental neuropathy: role of the medullospinal serotonergic pathway. Journal of Neurophysiology. jn.00836.2016. PMID 28053243 DOI: 10.1152/Jn.00836.2016  0.449
2016 Pertovaara A, Breivik H. Pain treatment with intrathecal corticosteroids: Much ado about nothing? But epidural corticosteroids for radicular pain is still an option. Scandinavian Journal of Pain. 10: 82-84. PMID 28361777 DOI: 10.1016/J.Sjpain.2015.10.007  0.443
2016 Pertovaara A. Mechanisms of cognitive impairment in chronic pain patients can now be studied preclinically by inducing cognitive deficits with an experimental animal model of chronic neuropathic pain. Scandinavian Journal of Pain. 10: 106-107. PMID 28361758 DOI: 10.1016/J.Sjpain.2015.11.006  0.35
2016 Lindholm P, Lamusuo S, Taiminen T, Virtanen A, Pertovaara A, Forssell H, Hagelberg N, Jääskeläinen S. The analgesic effect of therapeutic rTMS is not mediated or predicted by comorbid psychiatric or sleep disorders. Medicine. 95: e5231. PMID 27858874 DOI: 10.1097/Md.0000000000005231  0.313
2016 Wei H, Wu HY, Chen Z, Ma AN, Mao XF, Li TF, Li XY, Wang YX, Pertovaara A. Mechanical antihypersensitivity effect induced by repeated spinal administrations of a TRPA1 antagonist or a gap junction decoupler in peripheral neuropathy. Pharmacology, Biochemistry, and Behavior. PMID 27677209 DOI: 10.1016/J.Pbb.2016.09.007  0.413
2016 Li Z, Wei H, Piirainen S, Chen Z, Kalso E, Pertovaara A, Tian L. Spinal versus brain microglial and macrophage activation traits determine the differential neuroinflammatory responses and analgesic effect of minocycline in chronic neuropathic pain. Brain, Behavior, and Immunity. PMID 27262531 DOI: 10.1016/j.bbi.2016.05.021  0.323
2016 Wei H, Wu HY, Fan H, Li TF, Ma AN, Li XY, Wang YX, Pertovaara A. Potential role of spinal TRPA1 channels in antinociceptive tolerance to spinally administered morphine. Pharmacological Reports : Pr. 68: 472-475. PMID 26922555 DOI: 10.1016/J.Pharep.2015.11.008  0.337
2016 Li Z, Wei H, Piirainen S, Chen Z, Kalso E, Pertovaara A, Tian L. Differential microglial inflammatory responses in the spinal cord and brain towards chronic neuropathic pain in rats European Neuropsychopharmacology. 26: S196. DOI: 10.1016/S0924-977X(16)31036-7  0.436
2015 Wei H, Viisanen H, You HJ, Pertovaara A. Spinal histamine in attenuation of mechanical hypersensitivity in the spinal nerve ligation-induced model of experimental neuropathy. European Journal of Pharmacology. PMID 26723513 DOI: 10.1016/J.Ejphar.2015.12.039  0.496
2015 Amorim D, Viisanen H, Wei H, Almeida A, Pertovaara A, Pinto-Ribeiro F. Galanin-Mediated Behavioural Hyperalgesia from the Dorsomedial Nucleus of the Hypothalamus Involves Two Independent Descending Pronociceptive Pathways. Plos One. 10: e0142919. PMID 26565961 DOI: 10.1371/Journal.Pone.0142919  0.421
2015 David-Pereira A, Puga S, Gonçalves S, Amorim D, Silva C, Pertovaara A, Almeida A, Pinto-Ribeiro F. Metabotropic glutamate 5 receptor in the infralimbic cortex contributes to descending pain facilitation in healthy and arthritic animals. Neuroscience. PMID 26548413 DOI: 10.1016/J.Neuroscience.2015.10.060  0.325
2015 Wei H, Sagalajev B, Yüzer MA, Koivisto A, Pertovaara A. Regulation of neuropathic pain behavior by amygdaloid TRPC4/C5 channels. Neuroscience Letters. 608: 12-7. PMID 26432495 DOI: 10.1016/J.Neulet.2015.09.033  0.508
2015 Lindholm P, Lamusuo S, Taiminen T, Pesonen U, Lahti A, Virtanen A, Forssell H, Hietala J, Hagelberg N, Pertovaara A, Parkkola R, Jääskeläinen S. Right secondary somatosensory cortex-a promising novel target for the treatment of drug-resistant neuropathic orofacial pain with repetitive transcranial magnetic stimulation. Pain. 156: 1276-1283. PMID 25830924 DOI: 10.1097/J.Pain.0000000000000175  0.44
2015 Sagalajev B, Bourbia N, Beloushko E, Wei H, Pertovaara A. Bidirectional amygdaloid control of neuropathic hypersensitivity mediated by descending serotonergic pathways acting on spinal 5-HT3 and 5-HT1A receptors. Behavioural Brain Research. 282: 14-24. PMID 25557801 DOI: 10.1016/J.Bbr.2014.12.052  0.8
2015 Lei J, Pertovaara A, You HJ. Effects of simulated weightlessness on intramuscular hypertonic saline induced muscle nociception and spinal Fos expression in rats. Brain Research. 1594: 204-14. PMID 25446440 DOI: 10.1016/J.Brainres.2014.11.022  0.354
2015 Li Z, Wei H, Kalso E, Pertovaara A, Tian L. Differential microglial inflammatory responses in the spinal cord and brain towards the chronic neuropathic pain in rats Brain Behavior and Immunity. 49. DOI: 10.1016/J.Bbi.2015.06.169  0.456
2014 Pertovaara A. Sinomenine against neuropathic pain hypersensitivity. Scandinavian Journal of Pain. 5: 248. PMID 29911572 DOI: 10.1016/J.Sjpain.2014.08.002  0.457
2014 Amorim D, David-Pereira A, Marques P, Puga S, Rebelo P, Costa P, Pertovaara A, Almeida A, Pinto-Ribeiro F. A role of supraspinal galanin in behavioural hyperalgesia in the rat. Plos One. 9: e113077. PMID 25405608 DOI: 10.1371/Journal.Pone.0113077  0.496
2014 Wei H, Jin CY, Viisanen H, You HJ, Pertovaara A. Histamine in the locus coeruleus promotes descending noradrenergic inhibition of neuropathic hypersensitivity. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 90: 58-66. PMID 25304183 DOI: 10.1016/J.Phrs.2014.09.007  0.484
2014 Jääskeläinen SK, Lindholm P, Valmunen T, Pesonen U, Taiminen T, Virtanen A, Lamusuo S, Forssell H, Hagelberg N, Hietala J, Pertovaara A. Variation in the dopamine D2 receptor gene plays a key role in human pain and its modulation by transcranial magnetic stimulation. Pain. 155: 2180-7. PMID 25180011 DOI: 10.1016/J.Pain.2014.08.029  0.431
2014 Bourbia N, Sagalajev B, Pertovaara A. Descending effect on spinal nociception by amygdaloid glutamate varies with the submodality of noxious test stimulation. Neuroscience Letters. 570: 26-31. PMID 24747685 DOI: 10.1016/J.Neulet.2014.04.010  0.808
2014 Song Z, Viisanen H, Meyerson BA, Pertovaara A, Linderoth B. Efficacy of kilohertz-frequency and conventional spinal cord stimulation in rat models of different pain conditions. Neuromodulation : Journal of the International Neuromodulation Society. 17: 226-34; discussion 2. PMID 24612269 DOI: 10.1111/Ner.12161  0.443
2014 Amorim D, David-Pereira A, Pertovaara A, Almeida A, Pinto-Ribeiro F. Amitriptyline reverses hyperalgesia and improves associated mood-like disorders in a model of experimental monoarthritis. Behavioural Brain Research. 265: 12-21. PMID 24518202 DOI: 10.1016/J.Bbr.2014.02.003  0.419
2014 Koivisto A, Chapman H, Jalava N, Korjamo T, Saarnilehto M, Lindstedt K, Pertovaara A. TRPA1: a transducer and amplifier of pain and inflammation. Basic & Clinical Pharmacology & Toxicology. 114: 50-5. PMID 24102997 DOI: 10.1111/Bcpt.12138  0.498
2014 Jaeaeskelaeinen S, Lindholm P, Lamusuo S, Lahti A, Pesonen U, Taiminen T, Virtanen A, Forssell H, Hietala J, Hagelberg N, Parkkola R, Pertovaara A. P656: S2 cortex – a promising novel target for the treatment of neuropathic pain with rTMS Clinical Neurophysiology. 125. DOI: 10.1016/S1388-2457(14)50750-X  0.379
2013 Koivisto A, Pertovaara A. Transient receptor potential ankyrin 1 (TRPA1) ion channel in the pathophysiology of peripheral diabetic neuropathy. Scandinavian Journal of Pain. 4: 129-136. PMID 29913916 DOI: 10.1016/J.Sjpain.2012.11.001  0.358
2013 Pertovaara A. It's not cool to reduce the skin temperature and activate the TRPM8 ion channel after spinal injury. Scandinavian Journal of Pain. 4: 31-32. PMID 29913881 DOI: 10.1016/J.Sjpain.2012.11.002  0.459
2013 Pinto-Ribeiro F, Amorim D, David-Pereira A, Monteiro AM, Costa P, Pertovaara A, Almeida A. Pronociception from the dorsomedial nucleus of the hypothalamus is mediated by the rostral ventromedial medulla in healthy controls but is absent in arthritic animals. Brain Research Bulletin. 99: 100-8. PMID 24121166 DOI: 10.1016/J.Brainresbull.2013.10.001  0.44
2013 Song Z, Ansah OB, Meyerson BA, Pertovaara A, Linderoth B. Exploration of supraspinal mechanisms in effects of spinal cord stimulation: role of the locus coeruleus. Neuroscience. 253: 426-434. PMID 24036376 DOI: 10.1016/J.Neuroscience.2013.09.006  0.476
2013 Wei H, Gong N, Huang JL, Fan H, Ma AN, Li XY, Wang YX, Pertovaara A. Spinal D-amino acid oxidase contributes to mechanical pain hypersensitivity induced by sleep deprivation in the rat. Pharmacology, Biochemistry, and Behavior. 111: 30-6. PMID 23958579 DOI: 10.1016/J.Pbb.2013.08.003  0.453
2013 Song Z, Ansah OB, Meyerson BA, Pertovaara A, Linderoth B. The rostroventromedial medulla is engaged in the effects of spinal cord stimulation in a rodent model of neuropathic pain. Neuroscience. 247: 134-144. PMID 23711584 DOI: 10.1016/J.Neuroscience.2013.05.027  0.518
2013 Pertovaara A. The noradrenergic pain regulation system: a potential target for pain therapy. European Journal of Pharmacology. 716: 2-7. PMID 23500194 DOI: 10.1016/J.Ejphar.2013.01.067  0.516
2013 Wei H, Viisanen H, Amorim D, Koivisto A, Pertovaara A. Dissociated modulation of conditioned place-preference and mechanical hypersensitivity by a TRPA1 channel antagonist in peripheral neuropathy. Pharmacology, Biochemistry, and Behavior. 104: 90-6. PMID 23287802 DOI: 10.1016/J.Pbb.2012.12.014  0.424
2013 Pertovaara A, Martikainen IK, Hagelberg N, Hirvonen J, Scheinin H, Hietala J. S.02.02 Dopamine D2 and serotonin 5-HT1A receptors of the brain in processing of pain European Neuropsychopharmacology. 23. DOI: 10.1016/S0924-977X(13)70127-5  0.385
2012 Pertovaara A. Effective treatment of osteoarthritic pain, tackling the challenge with pets. Scandinavian Journal of Pain. 3: 82-83. PMID 29913772 DOI: 10.1016/J.Sjpain.2012.01.001  0.339
2012 Leite-Almeida H, Cerqueira JJ, Wei H, Ribeiro-Costa N, Anjos-Martins H, Sousa N, Pertovaara A, Almeida A. Differential effects of left/right neuropathy on rats' anxiety and cognitive behavior. Pain. 153: 2218-2225. PMID 22925700 DOI: 10.1016/J.Pain.2012.07.007  0.44
2012 Viisanen H, Ansah OB, Pertovaara A. The role of the dopamine D2 receptor in descending control of pain induced by motor cortex stimulation in the neuropathic rat. Brain Research Bulletin. 89: 133-43. PMID 22902996 DOI: 10.1016/J.Brainresbull.2012.08.002  0.453
2012 Hagelberg N, Aalto S, Tuominen L, Pesonen U, Någren K, Hietala J, Scheinin H, Pertovaara A, Martikainen IK. Striatal μ-opioid receptor availability predicts cold pressor pain threshold in healthy human subjects. Neuroscience Letters. 521: 11-4. PMID 22622175 DOI: 10.1016/J.Neulet.2012.05.042  0.461
2012 Wei H, Karimaa M, Korjamo T, Koivisto A, Pertovaara A. Transient receptor potential ankyrin 1 ion channel contributes to guarding pain and mechanical hypersensitivity in a rat model of postoperative pain. Anesthesiology. 117: 137-48. PMID 22588108 DOI: 10.1097/Aln.0B013E31825Adb0E  0.48
2012 Pertovaara A. The role of the amygdala in sensory and emotional-like pain behavior in neuropathic animals Scandinavian Journal of Pain. 3: 174. DOI: 10.1016/J.Sjpain.2012.05.005  0.422
2011 Taiminen T, Kuusalo L, Lehtinen L, Forssell H, Hagelberg N, Tenovuo O, Luutonen S, Pertovaara A, Jääskeläinen S. Psychiatric (axis I) and personality (axis II) disorders in patients with burning mouth syndrome or atypical facial pain. Scandinavian Journal of Pain. 2: 155-160. PMID 29913754 DOI: 10.1016/J.Sjpain.2011.06.004  0.38
2011 Pinto-Ribeiro F, Ansah OB, Almeida A, Pertovaara A. Response properties of nociceptive neurons in the caudal ventrolateral medulla (CVLM) in monoarthritic and healthy control rats: modulation of responses by the paraventricular nucleus of the hypothalamus (PVN). Brain Research Bulletin. 86: 82-90. PMID 21745547 DOI: 10.1016/J.Brainresbull.2011.06.014  0.405
2011 Pertovaara A, Koivisto A. TRPA1 ion channel in the spinal dorsal horn as a therapeutic target in central pain hypersensitivity and cutaneous neurogenic inflammation. European Journal of Pharmacology. 666: 1-4. PMID 21640097 DOI: 10.1016/J.Ejphar.2011.05.027  0.43
2011 Wei H, Koivisto A, Saarnilehto M, Chapman H, Kuokkanen K, Hao B, Huang JL, Wang YX, Pertovaara A. Spinal transient receptor potential ankyrin 1 channel contributes to central pain hypersensitivity in various pathophysiological conditions in the rat. Pain. 152: 582-91. PMID 21211906 DOI: 10.1016/J.Pain.2010.11.031  0.51
2011 Wei H, Scheinin M, Pertovaara A. T164 DOES AN ALPHA-2-ADRENOCEPTOR ANTAGONIST AUGMENT THE PAIN-SUPPRESSIVE EFFECT OF A PARTIAL OPIOID AGONIST IN A RAT MODEL OF PERIPHERAL NEUROPATHY? European Journal of Pain Supplements. 5: 33-34. DOI: 10.1016/S1754-3207(11)70109-2  0.313
2010 Pertovaara A. Suppression of pain behavior in nerve-injured rats by an anti-inflammatory drug: Promises and caveats for translation to clinical applications in man. Scandinavian Journal of Pain. 1: 227-228. PMID 29913993 DOI: 10.1016/J.Sjpain.2010.09.002  0.452
2010 Wei H, Hao B, Huang JL, Ma AN, Li XY, Wang YX, Pertovaara A. Intrathecal administration of a gap junction decoupler, an inhibitor of Na(+)-K(+)-2Cl(-) cotransporter 1, or a GABA(A) receptor agonist attenuates mechanical pain hypersensitivity induced by REM sleep deprivation in the rat. Pharmacology, Biochemistry, and Behavior. 97: 377-83. PMID 20851713 DOI: 10.1016/J.Pbb.2010.09.007  0.463
2010 Kambur O, Talka R, Ansah O, Kontinen V, Pertovaara A, Kalso E, Männistö P. Inhibitors of catechol-O-methyltransferase sensitize mice to pain. British Journal of Pharmacology. 161: 1553-1565. PMID 20726980 DOI: 10.1111/J.1476-5381.2010.00999.X  0.449
2010 Bourbia N, Ansah OB, Pertovaara A. Corticotropin-releasing factor in the rat amygdala differentially influences sensory-discriminative and emotional-like pain response in peripheral neuropathy. The Journal of Pain : Official Journal of the American Pain Society. 11: 1461-71. PMID 20624690 DOI: 10.1016/J.Jpain.2010.05.004  0.812
2010 Wei H, Koivisto A, Pertovaara A. Spinal TRPA1 ion channels contribute to cutaneous neurogenic inflammation in the rat. Neuroscience Letters. 479: 253-6. PMID 20566388 DOI: 10.1016/J.Neulet.2010.05.073  0.363
2010 Viisanen H, Pertovaara A. Roles of the rostroventromedial medulla and the spinal 5-HT(1A) receptor in descending antinociception induced by motor cortex stimulation in the neuropathic rat. Neuroscience Letters. 476: 133-7. PMID 20398735 DOI: 10.1016/J.Neulet.2010.04.014  0.424
2010 Tikhonravov D, Neuvonen T, Pertovaara A, Savioja K, Ruusuvirta T, Näätänen R, Carlson S. Dose-related effects of memantine on a mismatch negativity-like response in anesthetized rats. Neuroscience. 167: 1175-82. PMID 20298759 DOI: 10.1016/J.Neuroscience.2010.03.014  0.317
2010 Ansah OB, Bourbia N, Gonçalves L, Almeida A, Pertovaara A. Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat. Behavioural Brain Research. 209: 174-8. PMID 20097232 DOI: 10.1016/J.Bbr.2010.01.021  0.806
2010 Wei H, Chapman H, Saarnilehto M, Kuokkanen K, Koivisto A, Pertovaara A. Roles of cutaneous versus spinal TRPA1 channels in mechanical hypersensitivity in the diabetic or mustard oil-treated non-diabetic rat. Neuropharmacology. 58: 578-84. PMID 20004676 DOI: 10.1016/J.Neuropharm.2009.12.001  0.321
2010 Viisanen H, Pertovaara A. Antinociception by motor cortex stimulation in the neuropathic rat: does the locus coeruleus play a role? Experimental Brain Research. 201: 283-96. PMID 19826796 DOI: 10.1007/S00221-009-2038-4  0.431
2009 Martikainen IK, Hirvonen J, Pesonen U, Hagelberg N, Laurikainen H, Tuikkala H, Kajander J, Någren K, Hietala J, Pertovaara A. Differential associations between brain 5-HT(1A) receptor binding and response to pain versus touch. Journal of Neural Transmission (Vienna, Austria : 1996). 116: 821-30. PMID 19533293 DOI: 10.1007/S00702-009-0248-3  0.364
2009 Wei H, Viisanen H, Pertovaara A. Descending modulation of neuropathic hypersensitivity by dopamine D2 receptors in or adjacent to the hypothalamic A11 cell group. Pharmacological Research. 59: 355-63. PMID 19416636 DOI: 10.1016/J.Phrs.2009.01.001  0.342
2009 Leite-Almeida H, Almeida-Torres L, Mesquita AR, Pertovaara A, Sousa N, Cerqueira JJ, Almeida A. The impact of age on emotional and cognitive behaviours triggered by experimental neuropathy in rats. Pain. 144: 57-65. PMID 19398158 DOI: 10.1016/J.Pain.2009.02.024  0.383
2009 Valmunen T, Pertovaara A, Taiminen T, Virtanen A, Parkkola R, Jääskeläinen SK. Modulation of facial sensitivity by navigated rTMS in healthy subjects. Pain. 142: 149-58. PMID 19201092 DOI: 10.1016/J.Pain.2008.12.031  0.38
2009 Ansah OB, Gonçalves L, Almeida A, Pertovaara A. Enhanced pronociception by amygdaloid group I metabotropic glutamate receptors in nerve-injured animals. Experimental Neurology. 216: 66-74. PMID 19094988 DOI: 10.1016/J.Expneurol.2008.11.005  0.497
2009 Kojo I, Pertovaara A. Effect of tourniquet-induced ischemia on cutaneous thermal thresholds. Acta Neurologica Scandinavica. 74: 383-386. PMID 3825496 DOI: 10.1111/J.1600-0404.1986.Tb03530.X  0.435
2009 Ansah OB, Goncalves L, Almeida A, Pertovaara A. 378 Influence Of Amygdaloid Glutamatergic Receptors On Sensory And Affective Pain‐Related Responses In The Neuropathic Rat European Journal of Pain. 13. DOI: 10.1016/S1090-3801(09)60381-5  0.38
2008 Wei H, Ma A, Wang YX, Pertovaara A. Role of spinal 5-HT receptors in cutaneous hypersensitivity induced by REM sleep deprivation. Pharmacological Research. 57: 469-75. PMID 18602835 DOI: 10.1016/J.Phrs.2008.05.007  0.342
2008 Gonçalves L, Silva R, Pinto-Ribeiro F, Pêgo JM, Bessa JM, Pertovaara A, Sousa N, Almeida A. Neuropathic pain is associated with depressive behaviour and induces neuroplasticity in the amygdala of the rat. Experimental Neurology. 213: 48-56. PMID 18599044 DOI: 10.1016/J.Expneurol.2008.04.043  0.467
2008 Tikhonravov D, Neuvonen T, Pertovaara A, Savioja K, Ruusuvirta T, Näätänen R, Carlson S. Effects of an NMDA-receptor antagonist MK-801 on an MMN-like response recorded in anesthetized rats. Brain Research. 1203: 97-102. PMID 18325485 DOI: 10.1016/J.Brainres.2008.02.006  0.359
2008 Pinto-Ribeiro F, Ansah OB, Almeida A, Pertovaara A. Influence of arthritis on descending modulation of nociception from the paraventricular nucleus of the hypothalamus. Brain Research. 1197: 63-75. PMID 18242585 DOI: 10.1016/J.Brainres.2007.12.038  0.435
2008 Pertovaara A, Wei H. Dual influence of the striatum on neuropathic hypersensitivity. Pain. 137: 50-59. PMID 17870240 DOI: 10.1016/J.Pain.2007.08.009  0.437
2007 Gonçalves L, Almeida A, Pertovaara A. Pronociceptive changes in response properties of rostroventromedial medullary neurons in a rat model of peripheral neuropathy. The European Journal of Neuroscience. 26: 2188-95. PMID 17892482 DOI: 10.1111/J.1460-9568.2007.05832.X  0.362
2007 Martikainen IK, Hirvonen J, Kajander J, Hagelberg N, Mansikka H, Någren K, Hietala J, Pertovaara A. Correlation of human cold pressor pain responses with 5-HT(1A) receptor binding in the brain. Brain Research. 1172: 21-31. PMID 17803974 DOI: 10.1016/J.Brainres.2007.07.036  0.352
2007 Ansah OB, Pertovaara A. Peripheral suppression of arthritic pain by intraarticular fadolmidine, an alpha 2-adrenoceptor agonist, in the rat. Anesthesia and Analgesia. 105: 245-50. PMID 17578982 DOI: 10.1213/01.Ane.0000265850.08385.A6  0.426
2007 Ansah OB, Leite-Almeida H, Wei H, Pertovaara A. Striatal dopamine D2 receptors attenuate neuropathic hypersensitivity in the rat. Experimental Neurology. 205: 536-46. PMID 17451685 DOI: 10.1016/J.Expneurol.2007.03.010  0.45
2007 Viisanen H, Pertovaara A. Influence of peripheral nerve injury on response properties of locus coeruleus neurons and coeruleospinal antinociception in the rat. Neuroscience. 146: 1785-1794. PMID 17445989 DOI: 10.1016/J.Neuroscience.2007.03.016  0.507
2007 Wei H, Zhao W, Wang YX, Pertovaara A. Pain-related behavior following REM sleep deprivation in the rat: influence of peripheral nerve injury, spinal glutamatergic receptors and nitric oxide. Brain Research. 1148: 105-12. PMID 17368427 DOI: 10.1016/J.Brainres.2007.02.040  0.449
2007 Ansah OB, Leite-Almeida H, Wei H, Pertovaara A. 371 Striatal Dopamine D2 Receptors Attenuate Neuropathic Hypersensitivity In The Rat European Journal of Pain. 11: 1-5. DOI: 10.1016/J.Ejpain.2007.03.386  0.304
2007 Martikainen IK, Hirvonen J, Hagelberg N, Pesonen U, Kajander J, Nagren K, Hietala J, Pertovaara A. 224 Differential Influence Of Brain 5-Ht1A Receptors On Pain Versus Touch European Journal of Pain. 11: 98-99. DOI: 10.1016/J.Ejpain.2007.03.239  0.424
2007 Hagelberg N, Martikainen IK, Aalto S, Nagren K, Pesonen U, Hietala J, Scheinin H, Pertovaara A. 220 μ-Opioid receptor binding potential in the forebrain correlates with pain modulation in healthy subjects European Journal of Pain. 11. DOI: 10.1016/J.Ejpain.2007.03.235  0.411
2007 Goncalves L, Ansah OB, Almeida A, Pertovaara A. 149 Response Properties Of Nociceptive Neurons In The Amygdala Of The Neuropathic Rat European Journal of Pain. 11: 64-65. DOI: 10.1016/J.Ejpain.2007.03.164  0.332
2007 Pertovaara A. 113 Modulation Of Pain By The Striatum, A Potential Culprit In Rls European Journal of Pain. 11. DOI: 10.1016/J.Ejpain.2007.03.127  0.448
2006 Pertovaara A, Almeida A. Chapter 13 Descending inhibitory systems. Handbook of Clinical Neurology. 81: 179-92. PMID 18808835 DOI: 10.1016/S0072-9752(06)80017-5  0.502
2006 Pertovaara A. Noradrenergic pain modulation. Progress in Neurobiology. 80: 53-83. PMID 17030082 DOI: 10.1016/J.Pneurobio.2006.08.001  0.521
2006 Wei H, Pertovaara A. Spinal and pontine alpha2-adrenoceptors have opposite effects on pain-related behavior in the neuropathic rat. European Journal of Pharmacology. 551: 41-9. PMID 17027962 DOI: 10.1016/J.Ejphar.2006.08.064  0.469
2006 Wei H, Pertovaara A. 5-HT(1A) receptors in endogenous regulation of neuropathic hypersensitivity in the rat. European Journal of Pharmacology. 535: 157-65. PMID 16545367 DOI: 10.1016/J.Ejphar.2006.02.019  0.393
2006 Ylioja S, Carlson S, Raij TT, Pertovaara A. Localization of touch versus heat pain in the human hand: a dissociative effect of temporal parameters on discriminative capacity and decision strategy. Pain. 121: 6-13. PMID 16480826 DOI: 10.1016/J.Pain.2005.11.014  0.465
2005 Pertovaara A, Haapalinna A, Sirviö J, Virtanen R. Pharmacological properties, central nervous system effects, and potential therapeutic applications of atipamezole, a selective alpha2-adrenoceptor antagonist. Cns Drug Reviews. 11: 273-88. PMID 16389294 DOI: 10.1111/J.1527-3458.2005.Tb00047.X  0.344
2005 Pertovaara A, Östergård M, Änkö M-, Lehti-Koivunen S, Brandt A, Hong W, Korpi ER, Panula P. RFamide-related peptides signal through the neuropeptide FF receptor and regulate pain-related responses in the rat Neuroscience. 134: 1023-1032. PMID 16039797 DOI: 10.1016/J.Neuroscience.2005.04.050  0.386
2005 Mansikka H, Erbs E, Borrelli E, Pertovaara A. Influence of the dopamine D2 receptor knockout on pain-related behavior in the mouse. Brain Research. 1052: 82-7. PMID 15996639 DOI: 10.1016/J.Brainres.2005.06.021  0.406
2005 Martikainen IK, Hagelberg N, Mansikka H, Hietala J, Någren K, Scheinin H, Pertovaara A. Association of striatal dopamine D2/D3 receptor binding potential with pain but not tactile sensitivity or placebo analgesia. Neuroscience Letters. 376: 149-53. PMID 15721212 DOI: 10.1016/J.Neulet.2004.11.045  0.361
2004 Hagelberg N, Jääskeläinen SK, Martikainen IK, Mansikka H, Forssell H, Scheinin H, Hietala J, Pertovaara A. Striatal dopamine D2 receptors in modulation of pain in humans: a review. European Journal of Pharmacology. 500: 187-92. PMID 15464032 DOI: 10.1016/J.Ejphar.2004.07.024  0.428
2004 Pertovaara A, Martikainen IK, Hagelberg N, Mansikka H, Någren K, Hietala J, Scheinin H. Striatal dopamine D2/D3 receptor availability correlates with individual response characteristics to pain. The European Journal of Neuroscience. 20: 1587-92. PMID 15355325 DOI: 10.1111/J.1460-9568.2004.03622.X  0.369
2004 Kalmari J, Pertovaara A. Colorectal distension-induced suppression of a nociceptive somatic reflex response in the rat: modulation by tissue injury or inflammation. Brain Research. 1018: 106-10. PMID 15262211 DOI: 10.1016/J.Brainres.2004.05.064  0.357
2004 Mansikka H, Lähdesmäki J, Scheinin M, Pertovaara A. Alpha(2A) adrenoceptors contribute to feedback inhibition of capsaicin-induced hyperalgesia. Anesthesiology. 101: 185-90. PMID 15220790 DOI: 10.1097/00000542-200407000-00029  0.337
2004 Pertovaara A. Antinociceptive properties of fadolmidine (MPV-2426), a novel alpha2-adrenoceptor agonist. Cns Drug Reviews. 10: 117-26. PMID 15179442 DOI: 10.1111/J.1527-3458.2004.Tb00008.X  0.485
2004 Martikainen IK, Närhi MV, Pertovaara A. Spatial integration of cold pressor pain sensation in humans. Neuroscience Letters. 361: 140-3. PMID 15135913 DOI: 10.1016/J.Neulet.2003.12.060  0.411
2004 Kalliomäki ML, Pertovaara A, Brandt A, Wei H, Pietilä P, Kalmari J, Xu M, Kalso E, Panula P. Prolactin-releasing peptide affects pain, allodynia and autonomic reflexes through medullary mechanisms. Neuropharmacology. 46: 412-24. PMID 14975697 DOI: 10.1016/J.Neuropharm.2003.09.021  0.498
2003 Lähdesmäki J, Scheinin M, Pertovaara A, Mansikka H. The alpha2A-adrenoceptor subtype is not involved in inflammatory hyperalgesia or morphine-induced antinociception. European Journal of Pharmacology. 468: 183-9. PMID 12754056 DOI: 10.1016/S0014-2999(03)01677-7  0.345
2003 Pertovaara A, Wei H. A dissociative change in the efficacy of supraspinal versus spinal morphine in the neuropathic rat. Pain. 101: 237-250. PMID 12583866 DOI: 10.1016/S0304-3959(02)00320-2  0.458
2003 Niissalo S, Hampf G, Hietanen J, Malmström M, Solovieva S, Pertovaara A, Konttinen YT. Thermal sensation and pain in oral lichen planus and lichenoid reaction. Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 32: 41-5. PMID 12558957 DOI: 10.1034/J.1600-0714.2003.00048.X  0.355
2003 Pertovaara A, Kalmari J. Comparison of the visceral antinociceptive effects of spinally administered MPV-2426 (fadolmidine) and clonidine in the rat. Anesthesiology. 98: 189-94. PMID 12502996 DOI: 10.1097/00000542-200301000-00029  0.349
2002 Hagelberg N, Martikainen IK, Mansikka H, Hinkka S, Någren K, Hietala J, Scheinin H, Pertovaara A. Dopamine D2 receptor binding in the human brain is associated with the response to painful stimulation and pain modulatory capacity. Pain. 99: 273-9. PMID 12237205 DOI: 10.1016/S0304-3959(02)00121-5  0.477
2002 Wei H, Jyväsjärvi E, Niissalo S, Hukkanen M, Waris E, Konttinen YT, Pertovaara A. The influence of chemical sympathectomy on pain responsivity and α2-adrenergic antinociception in neuropathic animals Neuroscience. 114: 655-668. PMID 12220567 DOI: 10.1016/S0306-4522(02)00328-7  0.515
2002 Mansikka H, Zhou L, Donovan DM, Pertovaara A, Raja SN. The role of mu-opioid receptors in inflammatory hyperalgesia and alpha 2-adrenoceptor-mediated antihyperalgesia. Neuroscience. 113: 339-49. PMID 12127091 DOI: 10.1016/S0306-4522(02)00189-6  0.368
2002 Kauppila T, Kontinen VK, Wei H, Jyväsjärvi E, Pertovaara A. Cutaneous vascular responses evoked by noxious stimulation in rats with the spinal nerve ligation-induced model of neuropathy. Brain Research Bulletin. 58: 21-26. PMID 12121808 DOI: 10.1016/S0361-9230(02)00751-7  0.359
2002 Pertovaara A, Kalmari J. Neuropathy reduces viscero-somatic inhibition via segmental mechanisms in rats. Neuroreport. 13: 1047-1050. PMID 12060806 DOI: 10.1097/00001756-200206120-00014  0.399
2001 Pertovaara A, Wei H. Peripheral effects of morphine in neuropathic rats: role of sympathetic postganglionic nerve fibers European Journal of Pharmacology. 429: 139-145. PMID 11698036 DOI: 10.1016/S0014-2999(01)01315-2  0.383
2001 Pertovaara A, Keski-Vakkuri U, Kalmari J, Wei H, Panula P. Response properties of neurons in the rostroventromedial medulla of neuropathic rats: attempted modulation of responses by [1DMe]NPYF, a neuropeptide FF analogue Neuroscience. 105: 457-468. PMID 11672611 DOI: 10.1016/S0306-4522(01)00187-7  0.356
2001 Wei H, Panula P, Pertovaara A. Modulation of pain by [1DMe]NPYF, a stable analogue of neuropeptide FF, in neuropathic rats Brain Research. 900: 234-243. PMID 11334803 DOI: 10.1016/S0006-8993(01)02315-0  0.523
2001 Kalmari J, Niissalo S, Konttinen YT, Pertovaara A. Modulation of visceral nociceptive responses of rat spinal dorsal horn neurons by sympathectomy. Neuroreport. 12: 797-801. PMID 11277586 DOI: 10.1097/00001756-200103260-00036  0.385
2001 Kemppainen P, Vaalamo I, Leppälä N, Pertovaara A. Changes in tooth pulpal detection and pain thresholds in relation to jaw movement in man. Archives of Oral Biology. 46: 33-37. PMID 11163593 DOI: 10.1016/S0003-9969(00)00093-5  0.398
2001 Pertovaara A, Wei H, Kalmari J, Ruotsalainen M. Pain behavior and response properties of spinal dorsal horn neurons following experimental diabetic neuropathy in the rat: modulation by nitecapone, a COMT inhibitor with antioxidant properties. Experimental Neurology. 167: 425-434. PMID 11161631 DOI: 10.1006/Exnr.2000.7574  0.469
2000 Pertovaara A. Plasticity in descending pain modulatory systems. Progress in Brain Research. 129: 231-242. PMID 11098693 DOI: 10.1016/S0079-6123(00)29017-1  0.521
2000 Onttonen T, Kalmari J, Pertovaara A. Selective and segmentally restricted antinociception induced by MPV-2426, a novel alpha-2-adrenoceptor agonist, following intrathecal administration in the rat. Acta Anaesthesiologica Scandinavica. 44: 1077-1082. PMID 11028726 DOI: 10.1034/J.1399-6576.2000.440907.X  0.407
2000 Xu M, Wei H, Kontinen VK, Kalso E, Pertovaara A. The dissociation of sedative from spinal antinociceptive effects following administration of a novel alpha-2-adrenoceptor agonist, MPV-2426, in the locus coeruleus in the rat. Acta Anaesthesiologica Scandinavica. 44: 648-655. PMID 10903011 DOI: 10.1034/J.1399-6576.2000.440604.X  0.394
2000 Onttonen T, Pertovaara A. The Mechanical Antihyperalgesic Effect of Intrathecally Administered MPV-2426, a Novel α2-Adrenoceptor Agonist, in a Rat Model of Postoperative Pain Anesthesiology. 92: 1740-1745. PMID 10839926 DOI: 10.1097/00000542-200006000-00034  0.479
2000 Pertovaara A, Wei H. Attenuation of Ascending Nociceptive Signals to the Rostroventromedial Medulla Induced by a Novel α2-Adrenoceptor Agonist, MPV-2426, following Intrathecal Application in Neuropathic Rats Anesthesiology. 92: 1082-1092. PMID 10754629 DOI: 10.1097/00000542-200004000-00027  0.473
1999 Mansikka H, Jyväsjärvi E, Pertovaara A, Kauppila T. Allodynia induced by regenerating axons is not positively correlated with degree of autotomy in the rat. Neuroscience Letters. 276: 115-118. PMID 10624805 DOI: 10.1016/S0304-3940(99)00797-1  0.313
1999 Panula P, Kalso E, Nieminen M, Kontinen VK, Brandt A, Pertovaara A. Neuropeptide FF and modulation of pain. Brain Research. 848: 191-196. PMID 10612711 DOI: 10.1016/S0006-8993(99)02044-2  0.438
1999 Wei H, Pertovaara A. MK-801, an NMDA receptor antagonist, in the rostroventromedial medulla attenuates development of neuropathic symptoms in the rat. Neuroreport. 10: 2933-2937. PMID 10549800 DOI: 10.1097/00001756-199909290-00011  0.423
1999 Wei H, Pertovaara A. Influence of preemptive treatment with MK-801, an N-methyl-D-aspartate receptor antagonist, on development of neuropathic symptoms induced by spinal nerve ligation in the rat. Anesthesiology. 91: 313-316. PMID 10422960 DOI: 10.1097/00000542-199907000-00043  0.365
1999 Pertovaara A. The influence of stimulus temperature rise rate, adapting temperature, and stimulus duration on suprathreshold responses evoked by noxious heat in the glabrous skin of the limb. Comparison of neuronal discharge in the rat spinal dorsal horn with human sensations. Experimental Brain Research. 126: 482-494. PMID 10422711 DOI: 10.1007/S002210050756  0.409
1999 Kontinen VK, Kauppila T, Paananen S, Pertovaara A, Kalso E. Behavioural measures of depression and anxiety in rats with spinal nerve ligation-induced neuropathy. Pain. 80: 341-346. PMID 10204747 DOI: 10.1016/S0304-3959(98)00230-9  0.383
1999 Röyttä M, Wei H, Pertovaara A. Spinal nerve ligation-induced neuropathy in the rat: sensory disorders and correlation between histology of the peripheral nerves. Pain. 80: 161-70. PMID 10204728 DOI: 10.1016/S0304-3959(98)00199-7  0.392
1999 Kauppila T, Pertovaara A. Transection but not topical treatment of the sciatic nerve with capsaicin induces secondary hyperalgesia to mechanical stimulation in the saphenous nerve area of the rat Neuroscience Research Communications. 24: 99-106. DOI: 10.1002/(Sici)1520-6769(199903/04)24:2<99::Aid-Nrc5>3.0.Co;2-A  0.374
1998 Wei H, Panula P, Pertovaara A. A differential modulation of allodynia, hyperalgesia and nociception by neuropeptide FF in the periaqueductal gray of neuropathic rats: interactions with morphine and naloxone Neuroscience. 86: 311-319. PMID 9692764 DOI: 10.1016/S0306-4522(98)00027-X  0.427
1998 Kauppila T, Kontinen VK, Pertovaara A. Influence of spinalization on spinal withdrawal reflex responses varies depending on the submodality of the test stimulus and the experimental pathophysiological condition in the rat Brain Research. 797: 234-242. PMID 9666138 DOI: 10.1016/S0006-8993(98)00379-5  0.397
1998 Kauppila T, Kontinen VK, Pertovaara A. Weight bearing of the limb as a confounding factor in assessment of mechanical allodynia in the rat. Pain. 74: 55-59. PMID 9514560 DOI: 10.1016/S0304-3959(97)00143-7  0.346
1998 Pertovaara A, Hämäläinen MM, Kauppila T, Panula P. Carrageenan-induced changes in spinal nociception and its modulation by the brain stem. Neuroreport. 9: 351-5. PMID 9507982 DOI: 10.1097/00001756-199801260-00032  0.394
1998 Kauppila T, Jyväsjärvi E, Hämäläinen MM, Pertovaara A. The effect of a selective alpha2-adrenoceptor antagonist on pain behavior of the rat varies, depending on experimental parameters. Pharmacology, Biochemistry, and Behavior. 59: 477-85. PMID 9476998 DOI: 10.1016/S0091-3057(97)00393-6  0.475
1998 Pertovaara A. A Neuronal Correlate of Secondary Hyperalgesia in the Rat Spinal Dorsal Horn Is Submodality Selective and Facilitated by Supraspinal Influence Experimental Neurology. 149: 193-202. PMID 9454628 DOI: 10.1006/Exnr.1997.6688  0.397
1997 Wei H, Pertovaara A. Peripherally administered alpha2-adrenoceptor agonist in the modulation of chronic allodynia induced by spinal nerve ligation in the rat. Anesthesia & Analgesia. 85: 1122-1127. PMID 9356112 DOI: 10.1097/00000539-199711000-00030  0.385
1997 Pertovaara A, Kontinen VK, Kalso EA. Chronic spinal nerve ligation induces changes in response characteristics of nociceptive spinal dorsal horn neurons and in their descending regulation originating in the periaqueductal gray in the rat. Experimental Neurology. 147: 428-436. PMID 9344567 DOI: 10.1006/Exnr.1997.6555  0.429
1997 Kauppila T, Jyväsjärvi E, Murtomäki S, Mansikka H, Pertovaara A, Virtanen I, Liesi P. Use of paper for treatment of a peripheral nerve trauma in the rat Neuroreport. 8: 3151-3155. PMID 9331932 DOI: 10.1097/00001756-199709290-00029  0.345
1997 Mansikka H, Pertovaara A. Submodality-selective hyperalgesia adjacent to partially injured sciatic nerve in the rat is dependent on capsaicin-sensitive afferent fibers and independent of collateral sprouting or a dorsal root reflex. Brain Research Bulletin. 44: 237-245. PMID 9323437 DOI: 10.1016/S0361-9230(97)00114-7  0.342
1997 Kemppainen P, Waltimo A, Waltimo T, Könönen M, Pertovaara A. Differential Effects of Noxious Conditioning Stimulation of the Cheek by Capsaicin on Human Sensory and Inhibitory Masseter Reflex Responses Evoked by Tooth Pulp Stimulation Journal of Dental Research. 76: 1561-1568. PMID 9294490 DOI: 10.1177/00220345970760090801  0.421
1997 Grönroos M, Reunala T, Kartamaa M, Pertovaara A. Altered skin sensitivity in chronic itch: role of peripheral and central mechanisms Neuroscience Letters. 228: 199-202. PMID 9218642 DOI: 10.1016/S0304-3940(97)00405-9  0.383
1997 Mansikka H, Pertovaara A. Supraspinal influence on hindlimb withdrawal thresholds and mustard oil-induced secondary allodynia in rats. Brain Research Bulletin. 42: 359-365. PMID 9092877 DOI: 10.1016/S0361-9230(96)00313-9  0.376
1997 Pertovaara A. Further critical comments on the use of flexion reflex as a measure of pain sensitivity Pain Forum. 6: 110-112. DOI: 10.1016/S1082-3174(97)70042-4  0.492
1996 Pertovaara A, Wei H, Hämäläinen MM. Lidocaine in the rostroventromedial medulla and the periaqueductal gray attenuates allodynia in neuropathic rats. Neuroscience Letters. 218: 127-30. PMID 8945744 DOI: 10.1016/S0304-3940(96)13136-0  0.44
1996 Mansikka H, Idänpään-Heikkilä J-, Pertovaara A. Different roles of α2-adrenoceptors of the medulla versus the spinal cord in modulation of mustard oil-induced central hyperalgesia in rats European Journal of Pharmacology. 297: 19-26. PMID 8851161 DOI: 10.1016/0014-2999(95)00725-3  0.384
1996 Hämäläinen MM, Kauppila T, Taira T, Pertovaara A. A noninvasive method for studying quantitatively heat-evoked nocifensive hindlimb withdrawal reflexes in lightly anesthetized rats. Physiology & Behavior. 59: 389-92. PMID 8838621 DOI: 10.1016/0031-9384(95)02078-0  0.355
1996 Grönroos M, Reunala T, Pertovaara A. Influence of selective nerve fiber blocks on argon laser-induced thermal pain in the human skin Neuroscience Letters. 211: 143-145. PMID 8830865 DOI: 10.1016/0304-3940(96)12725-7  0.456
1996 Pertovaara A, Kauppila T, Hämäläinen MM. Influence of skin temperature on heat pain threshold in humans. Experimental Brain Research. 107: 497-503. PMID 8821389 DOI: 10.1007/Bf00230429  0.423
1996 Hämäläinen MM, Alila A, Johansson G, Pertovaara A. Cocaine-induced effects on pain behavior and C-fos expression in the spinal dorsal horn of the rat Neuroscience Research Communications. 19: 67-74. DOI: 10.1002/(Sici)1520-6769(199609)19:2<67::Aid-Nrc165>3.0.Co;2-R  0.43
1995 Mansikka H, Pertovaara A. Influence of selective α2-adrenergic agents on mustard oil-induced central hyperalgesia in rats European Journal of Pharmacology. 281: 43-48. PMID 8566115 DOI: 10.1016/0014-2999(95)00227-C  0.316
1995 Kauppila T, Grönroos M, Pertovaara A. An attempt to attenuate experimental pain in humans by dextromethorphan, an NMDA receptor antagonist. Pharmacology, Biochemistry and Behavior. 52: 641-644. PMID 8545487 DOI: 10.1016/0091-3057(95)00106-7  0.486
1995 Taira T, Tanila H, Jyväsjärvi E, Pertovaara A, Kauppila T. Activation of α2-adrenergic receptors decreases nerve trauma-induced afferent barrage but not autotomy Brain Research Bulletin. 36: 563-567. PMID 7757490 DOI: 10.1016/0361-9230(94)00245-V  0.485
1995 Mansikka H, Pertovaara A. The role of α2-adrenoceptors of the medullary lateral reticular nucleus in spinal antinociception in rats Brain Research Bulletin. 37: 633-638. PMID 7670889 DOI: 10.1016/0361-9230(95)00058-M  0.371
1995 Hämäläinen MM, Pertovaara A. The antinociceptive action of an alpha 2-adrenoceptor agonist in the spinal dorsal horn is due to a direct spinal action and not to activation of descending inhibition. Brain Research Bulletin. 37: 581-7. PMID 7670881 DOI: 10.1016/0361-9230(95)00044-F  0.367
1995 Hämäläinen MM, Jyväsjärvi E, Pertovaara A. Can the alpha 2-adrenoceptor agonist-mediated suppression of nocifensive reflex responses be due to action on motoneurons or peripheral nociceptors? Neuroscience Letters. 196: 29-32. PMID 7501249 DOI: 10.1016/0304-3940(95)11829-L  0.354
1994 Kemppainen P, Leppänen H, Jyväsjärvi E, Pertovaara A. Blood flow increase in the orofacial area of humans induced by painful stimulation. Brain Research Bulletin. 33: 655-662. PMID 8193919 DOI: 10.1016/0361-9230(94)90229-1  0.396
1994 Grönroos M, Pertovaara A. A selective suppression of human pain sensitivity by carbon dioxide: central mechanisms implicated. European Journal of Applied Physiology. 68: 74-79. PMID 8162926 DOI: 10.1007/Bf00599245  0.475
1994 Luukko M, Konttinen Y, Kemppinen P, Pertovaara A. Influence of various experimental parameters on the incidence of thermal and mechanical hyperalgesia induced by a constriction mononeuropathy of the sciatic nerve in lightly anesthetized rats. Experimental Neurology. 128: 143-154. PMID 8070519 DOI: 10.1006/Exnr.1994.1122  0.355
1994 Konttinen YT, Kemppinen P, Segerberg M, Hukkanen M, Rees R, Santavirta S, Sorsa T, Pertovaara A, Polak JM. Peripheral and spinal neural mechanisms in arthritis, with particular reference to treatment of inflammation and pain. Arthritis & Rheumatism. 37: 965-982. PMID 8024624 DOI: 10.1002/Art.1780370701  0.451
1994 Pertovaara A, Hämäläinen MM, Kauppila T, Mecke E, Carlson S. Dissociation of the alpha 2-adrenergic antinociception from sedation following microinjection of medetomidine into the locus coeruleus in rats. Pain. 57: 207-15. PMID 7916451 DOI: 10.1016/0304-3959(94)90225-9  0.444
1994 Pertovaara A, Helminen R, Mansikka H. The movement-induced modulation in discriminability between cutaneous nonpainful stimuli depends on test stimulus intensity. Experimental Brain Research. 101: 506-512. PMID 7851517 DOI: 10.1007/Bf00227343  0.306
1994 Grönroos M, Naukkarinen H, Pertovaara A. Capsaicin-induced central facilitation of a sympathetic vasoconstrictor response to painful stimulation in humans. Neuroscience Letters. 182: 163-166. PMID 7715802 DOI: 10.1016/0304-3940(94)90788-9  0.482
1994 Pertovaara A, Hämäläinen MM. Spinal potentiation and supraspinal additivity in the antinociceptive interaction between systemically administered alpha 2-adrenoceptor agonist and cocaine in the rat. Anesthesia and Analgesia. 79: 261-6. PMID 7639361 DOI: 10.1213/00000539-199408000-00010  0.326
1993 Kemppainen P, Leppänen H, Waltimo A, Pertovaara A. Effects of jaw clenching, jaw movement and static jaw position on facial skin sensitivity to non-painful electrical stimulation in man Archives of Oral Biology. 38: 303-308. PMID 8517802 DOI: 10.1016/0003-9969(93)90137-B  0.334
1993 Grönroos M, Pertovaara A. Capsaicin-induced central facilitation of a nociceptive flexion reflex in humans Neuroscience Letters. 159: 215-218. PMID 8264971 DOI: 10.1016/0304-3940(93)90837-B  0.443
1993 Hämäläinen MM, Pertovaara A. The rostroventromedial medulla is not involved in α2-adrenoceptor-mediated antinociception in the rat Neuropharmacology. 32: 1411-1418. PMID 8152531 DOI: 10.1016/0028-3908(93)90038-5  0.383
1993 Pertovaara A, Bravo R, Herdegen T. Induction and suppression of immediate-early genes in the rat brain by a selective alpha-2-adrenoceptor agonist and antagonist following noxious peripheral stimulation Neuroscience. 54: 117-126. PMID 8100045 DOI: 10.1016/0306-4522(93)90387-U  0.359
1993 Pertovaara A. Antinociception induced by alpha-2-adrenoceptor agonists, with special emphasis on medetomidine studies Progress in Neurobiology. 40: 691-709. PMID 8097888 DOI: 10.1016/0301-0082(93)90011-G  0.449
1993 Luukko M, Pertovaara A. Influence of an Experimental Peripheral Mononeuropathy on the Responses of Medial Bulboreticular Neurons to Noxious Skin Stimulation and the Modulation of the Responses by an α2-Adrenoceptor Agonist in the Rat Experimental Neurology. 124: 390-394. PMID 7904570 DOI: 10.1006/Exnr.1993.1212  0.395
1992 Huopaniemi T, Jyväsjärvi E, Carlson S, Lindroos F, Pertovaara A. Response characteristics of tooth pulp-driven postsynaptic neurons in the spinal trigeminal subnucleus oralis of the cat. Acta Physiologica Scandinavica. 144: 177-83. PMID 1575051 DOI: 10.1111/J.1748-1716.1992.Tb09283.X  0.364
1992 Kauppila T, Mecke E, Pertovaara A. Enhancement of morphine-induced analgesia and attenuation of morphine-induced side-effects by cocaine in rats. Pharmacology & Toxicology. 71: 173-178. PMID 1438038 DOI: 10.1111/J.1600-0773.1992.Tb00540.X  0.319
1992 Pertovaara A, Kemppainen P. Comments on Padawer and Levine, PAIN, 48 (1992) 132-135. Pain. 50: 239-240. PMID 1408325 DOI: 10.1016/0304-3959(92)90172-8  0.446
1991 Kauppila T, Pertovaara A. Effects of different sensory and behavioral manipulations on autotomy caused by a sciatic lesion in rats. Experimental Neurology. 111: 128-130. PMID 1984428 DOI: 10.1016/0014-4886(91)90059-L  0.314
1991 Pertovaara A. Antinociception in bulboreticular neurons of the rat produced by spinally administered medetomidine, an α2-adrenoceptor agonist European Journal of Pharmacology. 204: 9-14. PMID 1687126 DOI: 10.1016/0014-2999(91)90828-E  0.371
1991 Pertovaara A, Kauppila T, Jyväsjärvi E, Kalso E. Involvement of supraspinal and spinal segmental alpha-2-adrenergic mechanisms in the medetomidine-induced antinociception. Neuroscience. 44: 705-714. PMID 1684411 DOI: 10.1016/0306-4522(91)90089-7  0.401
1991 Pertovaara A, Kemppainen P, Kauppila T. The effects of medetomidine, an α-2-adrenoceptor agonist, and cocaine on the tooth pulp-evoked jaw-opening reflex in cat Pharmacology, Biochemistry and Behavior. 38: 287-292. PMID 1676169 DOI: 10.1016/0091-3057(91)90280-F  0.317
1991 Kauppila T, Kemppainen P, Tanila H, Pertovaara A. Effect of systemic medetomidine, an alpha2 adrenoceptor agonist, on experimental pain in humans Anesthesiology. 74: 3-8. PMID 1670912 DOI: 10.1097/00000542-199101000-00002  0.389
1991 Pertovaara A, Mecke E, Carlson S. Attempted reversal of cocaine-induced antinociceptive effects with naloxone, an opioid antagonist. European Journal of Pharmacology. 192: 349-53. PMID 1647316 DOI: 10.1016/0014-2999(91)90224-E  0.313
1990 Belczynski CR, Pertovaara A, Morrow TJ, Casey KL. The effect of systemic cocaine on spontaneous and nociceptively evoked activity of neurons in the medial and lateral thalamus. Brain Research. 517: 344-6. PMID 2376003 DOI: 10.1016/0006-8993(90)91048-L  0.33
1990 Belczynski CR, Pertovaara A, Morrow TJ, Casey KL. The effect of systemic cocaine on the responses to noxious stimuli and spontaneous activity of medial bulboreticular projection neurons. Brain Research. 527: 204-12. PMID 2253033 DOI: 10.1016/0006-8993(90)91139-8  0.336
1990 Pertovaara A, Tukeva T. Cocaine: effect on spinal projection neurons in the rat Brain Research Bulletin. 25: 1-6. PMID 2207695 DOI: 10.1016/0361-9230(90)90245-U  0.352
1990 Kemppainen P, Paalasmaa P, Pertovaara A, Alila A, Johansson G. Dexamethasone attenuates exercise-induced dental analgesia in man. Brain Research. 519: 329-32. PMID 2168784 DOI: 10.1016/0006-8993(90)90096-T  0.344
1990 Pertovaara A, Kauppila T, Tukeva T. The effect of medetomidine, an α2-adrenoceptor agonist, in various pain tests European Journal of Pharmacology. 179: 323-328. PMID 1973106 DOI: 10.1016/0014-2999(90)90172-3  0.381
1989 Huopaniemi T, Pertovaara A, Jyväsjärvi E, Carlson S. Effect of naloxone on tooth pulp-evoked jaw-opening reflex in the barbiturate-anaesthetized cat. Acta Physiologica Scandinavica. 134: 327-31. PMID 2852448 DOI: 10.1111/J.1748-1716.1988.Tb08499.X  0.373
1989 Pertovaara A, Tukeva T. Effect of subcutaneous formalin treatment on responses to bulboreticular nociceptive neurons in the rat. Brain Research Bulletin. 23: 457-462. PMID 2611686 DOI: 10.1016/0361-9230(89)90189-5  0.392
1989 Pertovaara A, Kauppila T. Effect of chronic sciatic nerve section on saphenous nerve input to midline bulboreticular formation in the rat. Neuroscience Letters. 105: 68-72. PMID 2485888 DOI: 10.1016/0304-3940(89)90013-X  0.331
1988 Pertovaara A, Belczynski CR, Morrow TJ, Casey KL. The effect of systemic cocaine on spinal nociceptive reflex activity in the rat. Brain Research. 438: 286-90. PMID 3345433 DOI: 10.1016/0006-8993(88)91348-0  0.338
1988 Pertovaara A, Morrow TJ, Casey KL. Cutaneous pain and detection thresholds to short CO2 laser pulses in humans: evidence on afferent mechanisms and the influence of varying stimulus conditions. Pain. 34: 261-9. PMID 3186273 DOI: 10.1016/0304-3959(88)90121-2  0.44
1987 Pertovaara A, Huopaniemi T, Aukee K, Carlson S. Tooth pulp-evoked activity in the spinal trigeminal nucleus caudalis of cat: comparison to primary afferent fiber, reflex, and sensory responses. Experimental Neurology. 95: 155-66. PMID 3792475 DOI: 10.1016/0014-4886(87)90014-8  0.381
1987 Pertovaara A, Huopaniemi T, Carlson S, Jyväsjärvi E. Response characteristics of tooth pulp-driven postsynaptic neurons in the spinal trigeminal subnucleus interpolaris of the cat: comparison with primary afferent fiber, subnucleus caudalis, reflex, and sensory responses. Brain Research. 422: 205-17. PMID 3676786 DOI: 10.1016/0006-8993(87)90928-0  0.384
1987 Virtanen ASJ, Huopaniemi T, Närhi MVO, Pertovaara A, Wallgren K. The effect of temporal parameters on subjective sensations evoked by electrical tooth stimulation. Pain. 30: 361-371. PMID 3670881 DOI: 10.1016/0304-3959(87)90024-8  0.465
1987 Kemppainen P, Pertovaara A, Huopaniemi T, Hämäläinen O, Grönblad M. Human Pain Thresholds after the Application of Lypressin, a Vasopressin Analogue Pharmacology & Toxicology. 61: 16-19. PMID 3628176 DOI: 10.1111/J.1600-0773.1987.Tb01765.X  0.466
1987 Kojo I, Pertovaara A. The Effects Of Stimulus Area And Adaptation Temperature On Warm And Heat Pain Thresholds In Man International Journal of Neuroscience. 32: 875-880. PMID 3596930 DOI: 10.3109/00207458709043342  0.403
1987 Nurmikko T, Pertovaara A, Pöntinen PJ. Attenuation of tourniquet-induced pain in man by D-phenylalanine, a putative inhibitor of enkephalin degradation. Acupuncture & Electro-Therapeutics Research. 12: 185-191. PMID 2895566 DOI: 10.3727/036012987816358841  0.437
1987 Pertovaara A, Huopaniemi T, Jyväsjärvi E, Carlson S. Response characteristics of tooth pulp-driven neurons in the spinal trigeminal nucleus interpolaris of cat Pain. 30. DOI: 10.1016/0304-3959(87)91603-4  0.33
1987 Kemppainen P, Pertovaara A, Huopaniemi T, Johansson G, Karonen LS. Stomatology Modification of dental pain and cutaneous thermal sensitivity by physical exercise in man Pain. 28: 269. DOI: 10.1016/0304-3959(87)90123-0  0.365
1986 Hari R, Pertovaara A, Kemppainen P, Salminen J. The effect of tourniquet-induced ischemia on somatically evoked cerebral magnetic fields in man. Acta Neurologica Scandinavica. 72: 419-26. PMID 4082907 DOI: 10.1111/J.1600-0404.1985.Tb00894.X  0.305
1986 Pertovaara A, Huopaniemi T, Aukee K. Tooth pulp-evoked jaw-opening reflex in the cat: evidence for central facilitation induced by noxious discharge in the intradental nerve fibers. Experimental Neurology. 92: 207-219. PMID 3956650 DOI: 10.1016/0014-4886(86)90135-4  0.34
1986 Kemppainen P, Pertovaara A, Huopaniemi T, Johansson G. Elevation of dental pain threshold induced in man by physical exercise is not reversed by cyproheptadine-mediated suppression of growth hormone release. Neuroscience Letters. 70: 388-92. PMID 3774237 DOI: 10.1016/0304-3940(86)90585-9  0.419
1985 Pertovaara A, Huopaniemi T, Virtanen A, Johansson G. The influence of exercise on dental pain thresholds and the release of stress hormones. Physiology & Behavior. 33: 923-6. PMID 6100393 DOI: 10.1016/0031-9384(84)90230-0  0.372
1985 Pertovaara A, Huopaniemi T. Effect of tourniquet-induced ischemia on magnitude scaling of tactile stimuli applied to the human hand. Perceptual and Motor Skills. 61: 535-544. PMID 4069919 DOI: 10.2466/Pms.1985.61.2.535  0.311
1985 Pertovaara A, Kojo I. Influence of the rate of temperature change on thermal thresholds in man Experimental Neurology. 87: 439-445. PMID 3972047 DOI: 10.1016/0014-4886(85)90174-8  0.358
1985 Kemppainen P, Pertovaara A, Huopaniemi T, Johansson G, Karonen S. Modification of dental pain and cutaneous thermal sensitivity by physical exercise in man. Brain Research. 360: 33-40. PMID 3000534 DOI: 10.1016/0006-8993(85)91217-X  0.395
1984 Nurmikko T, Pertovaara A. Painful hyperaesthesia following resection of the lateral cutaneous nerve of the thigh. Journal of Neurology, Neurosurgery, and Psychiatry. 47: 320-321. PMID 6707686 DOI: 10.1136/Jnnp.47.3.320-A  0.429
1984 Pertovaara A, Nurmikko T, Pöntinen PJ. Two separate components of pain produced by the submaximal effort tourniquet test Pain. 20: 53-58. PMID 6493789 DOI: 10.1016/0304-3959(84)90810-8  0.43
1984 Nurmikko T, Pertovaara A, Pöntinen PJ, Marnela K, Oja SS. Effect of L-tryptophan supplementation on ischemic pain. Acupuncture & Electro-Therapeutics Research. 9: 45-55. PMID 6145310 DOI: 10.3727/036012984816714820  0.434
1984 Kemppainen P, Pertovaara A, Johansson G. Dental pain thresholds and stress hormone release during the anticipation of noxious foot shocks Pain. 18: S49. DOI: 10.1016/0304-3959(84)90204-5  0.385
1982 Pertovaara A, Kemppainen P, Johansson G, Karonen S. Ischemic pain nonsegmentally produces a predominant reduction of pain and thermal sensitivity in man: A selective role for endogenous opioids Brain Research. 251: 83-92. PMID 6293648 DOI: 10.1016/0006-8993(82)91276-8  0.481
1982 Pertovaara A, Kemppainen P, Johansson G, Karonen S. Dental analgesia produced by non-painful low-frequency stimulation is not influenced by stress or reversed by naloxone Pain. 13: 379-384. PMID 6290963 DOI: 10.1016/0304-3959(82)90006-9  0.467
1981 Pertovaara A, Kemppainen P. The influence of naloxone on dental pain threshold elevation produced by peripheral conditioning stimulation at high frequency. Brain Research. 215: 426-429. PMID 6973381 DOI: 10.1016/0006-8993(81)90529-1  0.456
1980 Pertovaara A. Experimental Pain and Transcutaneous Electrical Nerve Stimulation at High Frequency Stereotactic and Functional Neurosurgery. 43: 290-297. PMID 7294774 DOI: 10.1159/000102268  0.421
1979 Pertovaara A. Modification of human pain threshold by specific tactile receptors. Acta Physiologica Scandinavica. 107: 339-341. PMID 232366 DOI: 10.1111/J.1748-1716.1979.Tb06485.X  0.464
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