| Year |
Citation |
Score |
| 2020 |
Mazor R, Pastan I. Immunogenicity of Immunotoxins Containing Exotoxin A: Causes, Consequences, and Mitigation. Frontiers in Immunology. 11: 1261. PMID 32695104 DOI: 10.3389/fimmu.2020.01261 |
0.358 |
|
| 2020 |
Inoue S, Tsunoda T, Riku M, Ito H, Inoko A, Murakami H, Ebi M, Ogasawara N, Pastan I, Kasugai K, Kasai K, Ikeda H, Inaguma S. Diffuse mesothelin expression leads to worse prognosis through enhanced cellular proliferation in colorectal cancer. Oncology Letters. 19: 1741-1750. PMID 32194667 DOI: 10.3892/ol.2020.11290 |
0.31 |
|
| 2020 |
Liu XF, Wei J, Zhou Q, Molitoris BA, Sandoval R, Kobayashi H, Okada R, Nagaya T, Karim B, Butcher D, Pastan I. Immunotoxin SS1P is rapidly removed by proximal tubule cells of kidney, whose damage contributes to albumin loss in urine. Proceedings of the National Academy of Sciences of the United States of America. PMID 32123080 DOI: 10.1073/pnas.1919038117 |
0.324 |
|
| 2019 |
Zheng Z, Okada R, Kobayashi H, Nagaya T, Wei J, Zhou Q, Lee F, Bera TK, Gao Y, Kuhlman W, Tai CH, Pastan I. Site-specific PEGylation of anti-mesothelin recombinant immunotoxins increases half-life and anti-tumor activity. Molecular Cancer Therapeutics. PMID 31871266 DOI: 10.1158/1535-7163.MCT-19-0890 |
0.31 |
|
| 2019 |
Fleming BD, Urban DJ, Hall M, Longerich T, Greten T, Pastan I, Ho M. The engineered anti-GPC3 immunotoxin, HN3-ABD-T20, produces regression in mouse liver cancer xenografts via prolonged serum retention. Hepatology (Baltimore, Md.). PMID 31520528 DOI: 10.1002/Hep.30949 |
0.307 |
|
| 2019 |
Cerise A, Bera TK, Liu X, Wei J, Pastan I. Anti-Mesothelin Recombinant Immunotoxin Therapy for Colorectal Cancer. Clinical Colorectal Cancer. PMID 31345777 DOI: 10.1016/j.clcc.2019.06.006 |
0.308 |
|
| 2019 |
Bera TK, Liu W, Leshem J, King E, Kozlov S, Pastan I. Generation of a Transgenic BALB/c Mouse Line With Selective Expression of Human Mesothelin in Thyroid Gland: Application in Mesothelin-targeted Immunotherapy. Journal of Immunotherapy (Hagerstown, Md. : 1997). PMID 30933045 DOI: 10.1097/CJI.0000000000000263 |
0.342 |
|
| 2019 |
Leshem Y, Pastan I. Exotoxin Immunotoxins and Anti-Tumor Immunity: From Observations at the Patient's Bedside to Evaluation in Preclinical Models. Toxins. 11. PMID 30621280 DOI: 10.3390/toxins11010020 |
0.303 |
|
| 2019 |
Leshem Y, King E, Reiter Y, Pastan I. Abstract A142: Anti-mesothelin immunotoxins induce markers of immunogenic cell death and when injected locally into AE17M mesothelioma tumors enhance the effect of CTLA-4 blockade Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-A142 |
0.302 |
|
| 2019 |
Kreitman R, Gorelik D, Stetler-Stevenson M, Yuan CM, Wang H, Zhou H, Potocka K, Fykes E, Arons E, Pastan I. Abstract CN07-03: Recombinant immunotoxins for hematologic malignancies Molecular Cancer Therapeutics. 18. DOI: 10.1158/1535-7163.Targ-19-Cn07-03 |
0.339 |
|
| 2019 |
Ho M, Fleming BD, Greten TF, Pastan I. Abstract CN07-02: Immunotoxins targeting GPC3 for liver cancer Molecular Cancer Therapeutics. 18. DOI: 10.1158/1535-7163.Targ-19-Cn07-02 |
0.309 |
|
| 2018 |
Okabe M, Motojima M, Miyazaki Y, Pastan I, Yokoo T, Matsusaka T. Global Polysome Analysis of Normal and Injured Podocytes. American Journal of Physiology. Renal Physiology. PMID 30379099 DOI: 10.1152/ajprenal.00115.2018 |
0.301 |
|
| 2018 |
Mazor R, King EM, Pastan I. Strategies to reduce the immunogenicity of recombinant immunotoxins. The American Journal of Pathology. PMID 29870741 DOI: 10.1016/j.ajpath.2018.04.016 |
0.33 |
|
| 2018 |
Kaplan G, Mazor R, Lee F, Jang Y, Leshem Y, Pastan I. Improving the in vivo efficacy of an anti-Tac (CD25) immunotoxin by Pseudomonas exotoxin A domain II engineering. Molecular Cancer Therapeutics. PMID 29695631 DOI: 10.1158/1535-7163.MCT-17-1041 |
0.32 |
|
| 2018 |
Wei J, Bera TK, Liu XF, Zhou Q, Onda M, Ho M, Tai CH, Pastan I. Recombinant immunotoxins with albumin-binding domains have long half-lives and high antitumor activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 29581296 DOI: 10.1073/pnas.1721780115 |
0.371 |
|
| 2018 |
Müller F, Cunningham T, Stookey S, Tai CH, Burkett S, Jailwala P, Stetler Stevenson M, Cam MC, Wayne AS, Pastan I. 5-Azacytidine prevents relapse and produces long-term complete remissions in leukemia xenografts treated with Moxetumomab pasudotox. Proceedings of the National Academy of Sciences of the United States of America. PMID 29432154 DOI: 10.1073/pnas.1714512115 |
0.349 |
|
| 2018 |
Mazor R, King EM, Onda M, Cuburu N, Addissie S, Crown D, Liu XF, Kishimoto TK, Pastan I. Tolerogenic nanoparticles restore the antitumor activity of recombinant immunotoxins by mitigating immunogenicity. Proceedings of the National Academy of Sciences of the United States of America. PMID 29311317 DOI: 10.1073/pnas.1717063115 |
0.306 |
|
| 2017 |
Liu XF, Zhou Q, Hassan R, Pastan I. Panbinostat decreases cFLIP and enhances killing of cancer cells by immunotoxin LMB-100 by stimulating the extrinsic apoptotic pathway. Oncotarget. 8: 87307-87316. PMID 29152082 DOI: 10.18632/oncotarget.20263 |
0.341 |
|
| 2017 |
Bera TK, Abe Y, Ise T, Oberle A, Gallardo D, Liu XF, Nagata S, Binder M, Pastan I. Recombinant immunotoxins targeting B-cell maturation antigen are cytotoxic to myeloma cell lines and myeloma cells from patients. Leukemia. PMID 29149102 DOI: 10.1038/leu.2017.315 |
0.341 |
|
| 2017 |
Leshem Y, O'Brien J, Liu X, Bera TK, Terabe M, Berzofsky JA, Bossenmaier B, Niederfellner G, Tai CH, Reiter Y, Pastan I. Combining Local Immunotoxins Targeting Mesothelin with CTLA-4 Blockade Synergistically Eradicates Murine Cancer by Promoting Anti-Cancer Immunity. Cancer Immunology Research. PMID 28674083 DOI: 10.1158/2326-6066.CIR-16-0330 |
0.307 |
|
| 2017 |
Inaguma S, Wang Z, Lasota J, Onda M, Czapiewski P, Langfort R, Rys J, Szpor J, Waloszczyk P, Okoń K, Biernat W, Ikeda H, Schrump DS, Hassan R, Pastan I, et al. Comprehensive immunohistochemical study of mesothelin (MSLN) using different monoclonal antibodies 5B2 and MN-1 in 1562 tumors with evaluation of its prognostic value in malignant pleural mesothelioma. Oncotarget. 8: 26744-26754. PMID 28460459 DOI: 10.18632/oncotarget.15814 |
0.307 |
|
| 2017 |
Müller F, Stookey S, Cunningham T, Pastan I. Paclitaxel synergizes with exposure time adjusted CD22-targeting immunotoxins against B-cell malignancies. Oncotarget. PMID 28423727 DOI: 10.18632/oncotarget.16141 |
0.338 |
|
| 2017 |
Mazor R, Kaplan G, Park D, Jang Y, Lee F, Kreitman R, Pastan I. Rational design of low immunogenic anti CD25 recombinant immunotoxin for T cell malignancies by elimination of T cell epitopes in PE38. Cellular Immunology. PMID 28087047 DOI: 10.1016/j.cellimm.2017.01.003 |
0.331 |
|
| 2017 |
Yu X, Keir ST, Szafranski S, Clayton S, Pastan I, Bigner DD, Chandramohan V. Immunotoxin and bcl-2 inhibitor combination therapy targeting chondroitin sulfate proteoglycan 4. Journal of Clinical Oncology. 35: 74-74. DOI: 10.1200/Jco.2017.35.7_Suppl.74 |
0.367 |
|
| 2016 |
Bao X, Pastan I, Bigner DD, Chandramohan V. EGFR/EGFRvIII-targeted immunotoxin therapy for the treatment of glioblastomas via convection-enhanced delivery. Receptors & Clinical Investigation. 3. PMID 28286803 DOI: 10.14800/Rci.1430 |
0.304 |
|
| 2016 |
Hassan R, Thomas A, Alewine C, Le DT, Jaffee EM, Pastan I. Mesothelin Immunotherapy for Cancer: Ready for Prime Time? Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 34: 4171-4179. PMID 27863199 DOI: 10.1200/Jco.2016.68.3672 |
0.332 |
|
| 2016 |
Mazor R, Addissie S, Jang Y, Tai CH, Rose J, Hakim F, Pastan I. Role of HLA-DP in the Presentation of Epitopes from the Truncated Bacterial PE38 Immunotoxin. The Aaps Journal. PMID 27796910 DOI: 10.1208/s12248-016-9986-y |
0.301 |
|
| 2016 |
Liu XF, Xiang L, Zhou Q, Carralot JP, Prunotto M, Niederfellner G, Pastan I. Actinomycin D enhances killing of cancer cells by immunotoxin RG7787 through activation of the extrinsic pathway of apoptosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 27601652 DOI: 10.1073/pnas.1611481113 |
0.322 |
|
| 2016 |
Antignani A, Mathews Griner L, Guha R, Simon N, Pasetto M, Keller J, Huang M, Angelus E, Pastan I, Ferrer M, FitzGerald DJ, Thomas CJ. Chemical Screens Identify Drugs that Enhance or Mitigate Cellular Responses to Antibody-Toxin Fusion Proteins. Plos One. 11: e0161415. PMID 27556570 DOI: 10.1371/Journal.Pone.0161415 |
0.341 |
|
| 2016 |
Bauss F, Lechmann M, Krippendorff BF, Staack R, Herting F, Festag M, Imhof-Jung S, Hesse F, Pompiati M, Kollmorgen G, da Silva Mateus Seidl R, Bossenmaier B, Lau W, Schantz C, Stracke JO, ... ... Pastan I, et al. Characterization of a re-engineered, mesothelin-targeted Pseudomonas exotoxin fusion protein for lung cancer therapy. Molecular Oncology. PMID 27507537 DOI: 10.1016/j.molonc.2016.07.003 |
0.322 |
|
| 2016 |
Kaplan G, Lee F, Onda M, Kolyvas E, Bhardwaj G, Baker D, Pastan I. Protection of the Furin Cleavage Site in Low-Toxicity Immunotoxins Based on Pseudomonas Exotoxin A. Toxins. 8. PMID 27463727 DOI: 10.3390/Toxins8080217 |
0.303 |
|
| 2016 |
Awuah P, Bera TK, Folivi M, Chertov O, Pastan I. Reduced Shedding of Surface Mesothelin Improves Efficacy of Mesothelin Targeting Recombinant Immunotoxins. Molecular Cancer Therapeutics. PMID 27196771 DOI: 10.1158/1535-7163.MCT-15-0863 |
0.346 |
|
| 2016 |
Mazor R, Onda M, Park D, Addissie S, Xiang L, Zhang J, Hassan R, Pastan I. Dual B- and T-cell de-immunization of recombinant immunotoxin targeting mesothelin with high cytotoxic activity. Oncotarget. PMID 27167198 DOI: 10.18632/oncotarget.9171 |
0.353 |
|
| 2016 |
Liu X, Mueller F, Wayne AS, Pastan I. Protein kinase inhibitor H89 enhances the activity of Pseudomonas exotoxin A-based immunotoxins. Molecular Cancer Therapeutics. PMID 26939705 DOI: 10.1158/1535-7163.MCT-15-0828 |
0.319 |
|
| 2016 |
Mazor R, Onda M, Pastan I. Immunogenicity of therapeutic recombinant immunotoxins. Immunological Reviews. 270: 152-64. PMID 26864110 DOI: 10.1111/imr.12390 |
0.331 |
|
| 2016 |
Antignani A, Mathews-Griner L, Ferrer M, Simon N, Angelus E, Huang M, Pastan I, Thomas C, FitzGerald DJ. Abstract A67: The mTOR inhibitor, everolimus, enhances the cytotoxicity of pseudomonas-based immunotoxins: Mechanistic insights Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Metca15-A67 |
0.331 |
|
| 2016 |
Alewine C, Landsman R, Rudloff M, Kolyvas E, Chen J, Pastan I. Abstract B37: Mesothelin-targeted immunotoxin RG7787 (LMB-100) preferentially depletes secreted proteins and short-lived intracellular proteins to augment tumor cell killing by taxanes Cancer Research. 76. DOI: 10.1158/1538-7445.Panca16-B37 |
0.33 |
|
| 2016 |
Ali-Rahmani F, Fitzgerald D, Martin S, Patel P, Prunotto M, Ormanoglu P, Thomas C, Pastan I. Abstract 743: Tyrosine kinase discoidin domain receptor-1 (DDR1) regulates cytotoxicity of recombinant immunotoxin for cancer therapy Cancer Research. 76: 743-743. DOI: 10.1158/1538-7445.Am2016-743 |
0.332 |
|
| 2016 |
Liu XF, Xiang L, Prunotto M, Niederfellner G, Pastan I. Abstract 1290: Actinomycin D enhanced immunotoxin RG7787 killing of cancer cells Cancer Research. 76: 1290-1290. DOI: 10.1158/1538-7445.Am2016-1290 |
0.33 |
|
| 2015 |
Ali-Rahmani F, FitzGerald DJ, Martin S, Patel P, Prunotto M, Ormanoglu P, Thomas C, Pastan I. Anticancer Effects of Mesothelin-targeted Immunotoxin Therapy are Regulated by Tyrosine Kinase DDR1. Cancer Research. PMID 26719540 DOI: 10.1158/0008-5472.Can-15-2401 |
0.356 |
|
| 2015 |
Kreitman RJ, Pastan I. Immunoconjugates in the management of hairy cell leukemia. Best Practice & Research. Clinical Haematology. 28: 236-45. PMID 26614902 DOI: 10.1016/j.beha.2015.09.003 |
0.346 |
|
| 2015 |
Mazor R, Crown D, Addissie S, Jang Y, Kaplan G, Pastan I. Elimination of murine and human T-cell epitopes in recombinant immunotoxin eliminates neutralizing and anti-drug antibodies in vivo. Cellular & Molecular Immunology. PMID 26477977 DOI: 10.1038/cmi.2015.91 |
0.312 |
|
| 2015 |
Hassan R, Alewine C, Pastan I. New Life for Immunotoxin Cancer Therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26463707 DOI: 10.1158/1078-0432.CCR-15-1623 |
0.3 |
|
| 2015 |
Mazor R, Zhang J, Xiang L, Addissie S, Awuah P, Beers R, Hassan R, Pastan I. Recombinant Immunotoxin with T Cell Epitope Mutations that Greatly Reduce Immunogenicity for Treatment of Mesothelin Expressing Tumors. Molecular Cancer Therapeutics. PMID 26443804 DOI: 10.1158/1535-7163.MCT-15-0532 |
0.338 |
|
| 2015 |
Stahl S, da Silva Mateus Seidl AR, Ducret A, Kux van Geijtenbeek S, Michel S, Racek T, Birzele F, Haas AK, Rueger R, Gerg M, Niederfellner G, Pastan I, Brinkmann U. Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor. Proceedings of the National Academy of Sciences of the United States of America. 112: 10732-7. PMID 26261303 DOI: 10.1073/pnas.1512863112 |
0.36 |
|
| 2015 |
Weldon JE, Skarzynski M, Therres JA, Ostovitz JR, Zhou H, Kreitman RJ, Pastan I. Designing the furin-cleavable linker in recombinant immunotoxins based on Pseudomonas exotoxin A. Bioconjugate Chemistry. 26: 1120-8. PMID 25997032 DOI: 10.1021/Acs.Bioconjchem.5B00190 |
0.345 |
|
| 2015 |
Zhang YF, Phung Y, Gao W, Kawa S, Hassan R, Pastan I, Ho M. New high affinity monoclonal antibodies recognize non-overlapping epitopes on mesothelin for monitoring and treating mesothelioma. Scientific Reports. 5: 9928. PMID 25996440 DOI: 10.1038/srep09928 |
0.341 |
|
| 2015 |
Müller N, Michen S, Tietze S, Töpfer K, Schulte A, Lamszus K, Schmitz M, Schackert G, Pastan I, Temme A. Engineering NK Cells Modified With an EGFRvIII-specific Chimeric Antigen Receptor to Overexpress CXCR4 Improves Immunotherapy of CXCL12/SDF-1α-secreting Glioblastoma. Journal of Immunotherapy (Hagerstown, Md. : 1997). 38: 197-210. PMID 25962108 DOI: 10.1097/CJI.0000000000000082 |
0.347 |
|
| 2015 |
Hollevoet K, Mason-Osann E, Müller F, Pastan I. Methylation-associated partial down-regulation of mesothelin causes resistance to anti-mesothelin immunotoxins in a pancreatic cancer cell line. Plos One. 10: e0122462. PMID 25803818 DOI: 10.1371/journal.pone.0122462 |
0.332 |
|
| 2015 |
Pasetto M, Antignani A, Ormanoglu P, Buehler E, Guha R, Pastan I, Martin SE, FitzGerald DJ. Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 112: E1135-42. PMID 25713356 DOI: 10.1073/Pnas.1501958112 |
0.347 |
|
| 2015 |
Alewine C, Hassan R, Pastan I. Advances in anticancer immunotoxin therapy. The Oncologist. 20: 176-85. PMID 25561510 DOI: 10.1634/theoncologist.2014-0358 |
0.348 |
|
| 2015 |
Leshem J, Liu X, Bera T, Terabe M, Berzofsky JA, Bossenmaier B, Niederfellner G, Pastan I. Combining anti-CTLA4 with RG7787, an immunotoxin targeting mesothelin, promotes tumor eradication Journal For Immunotherapy of Cancer. 3. DOI: 10.1186/2051-1426-3-S2-P190 |
0.334 |
|
| 2015 |
Mueller F, Liu X, Wayne AS, Pastan I. Immunotoxin Activity Against B-Lineage Leukemia and Lymphoma Is Exposure Time Dependent: Implications for Trial Design Blood. 126: 1332-1332. DOI: 10.1182/BLOOD.V126.23.1332.1332 |
0.319 |
|
| 2015 |
Ali-Rahmani FG, Fitzgerald D, Martin S, Patel P, Thomas C, Pastan I. Abstract 5357: Inhibition of collagen receptor discoidin domain receptor-1 (DDR1) tyrosine kinase enhances cytotoxicity of anti-mesothelin immunotoxin for cancer therapy Cancer Research. 75: 5357-5357. DOI: 10.1158/1538-7445.Am2015-5357 |
0.332 |
|
| 2015 |
Mueller F, Liu X, Wayne A, Pastan I. Abstract 3277: Optimized treatment schedule with the new generation CD22-targeting immunotoxin LMB11 induces near MRD-negativity in an ALL mouse model Cancer Research. 75: 3277-3277. DOI: 10.1158/1538-7445.Am2015-3277 |
0.304 |
|
| 2015 |
Alewine CC, Kolyvas E, Boslett K, Pastan I. Abstract 2566: Combination of taxanes with mesothelin-targeted immunotoxin RG7787 induces synergistic killing of pancreatic cancer Cancer Research. 75: 2566-2566. DOI: 10.1158/1538-7445.Am2015-2566 |
0.317 |
|
| 2015 |
Alewine CC, Kolyvas E, Pastan I. Abstract C163: Understanding the mechanism for synergistic anti-tumor activity of a meosthelin-targeted immunotoxin and taxanes Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-C163 |
0.326 |
|
| 2014 |
Pak Y, Pastan I, Kreitman RJ, Lee B. Effect of antigen shedding on targeted delivery of immunotoxins in solid tumors from a mathematical model. Plos One. 9: e110716. PMID 25343405 DOI: 10.1371/journal.pone.0110716 |
0.325 |
|
| 2014 |
Alewine C, Xiang L, Yamori T, Niederfellner G, Bosslet K, Pastan I. Efficacy of RG7787, a next-generation mesothelin-targeted immunotoxin, against triple-negative breast and gastric cancers. Molecular Cancer Therapeutics. 13: 2653-61. PMID 25239937 DOI: 10.1158/1535-7163.MCT-14-0132 |
0.302 |
|
| 2014 |
Hassan R, Kindler HL, Jahan T, Bazhenova L, Reck M, Thomas A, Pastan I, Parno J, O'Shannessy DJ, Fatato P, Maltzman JD, Wallin BA. Phase II clinical trial of amatuximab, a chimeric antimesothelin antibody with pemetrexed and cisplatin in advanced unresectable pleural mesothelioma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 5927-36. PMID 25231400 DOI: 10.1158/1078-0432.Ccr-14-0804 |
0.311 |
|
| 2014 |
Zhang J, Bera TK, Liu W, Du X, Alewine C, Hassan R, Pastan I. Megakaryocytic potentiating factor and mature mesothelin stimulate the growth of a lung cancer cell line in the peritoneal cavity of mice. Plos One. 9: e104388. PMID 25118887 DOI: 10.1371/journal.pone.0104388 |
0.322 |
|
| 2014 |
Wright SE, Rewers-Felkins KA, Quinlin I, Chowdhury NI, Ahmed J, Eldridge PW, Srivastava SK, Pastan I. TGFα-PE38 enhances cytotoxic T-lymphocyte killing of breast cancer cells. Oncology Letters. 7: 2113-2117. PMID 24932299 DOI: 10.3892/ol.2014.1969 |
0.347 |
|
| 2014 |
Hollevoet K, Mason-Osann E, Liu XF, Imhof-Jung S, Niederfellner G, Pastan I. In vitro and in vivo activity of the low-immunogenic antimesothelin immunotoxin RG7787 in pancreatic cancer. Molecular Cancer Therapeutics. 13: 2040-9. PMID 24928849 DOI: 10.1158/1535-7163.MCT-14-0089-T |
0.339 |
|
| 2014 |
Pastan I, Hassan R. Discovery of mesothelin and exploiting it as a target for immunotherapy. Cancer Research. 74: 2907-12. PMID 24824231 DOI: 10.1158/0008-5472.CAN-14-0337 |
0.316 |
|
| 2014 |
Mazor R, Eberle JA, Hu X, Vassall AN, Onda M, Beers R, Lee EC, Kreitman RJ, Lee B, Baker D, King C, Hassan R, Benhar I, Pastan I. Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes. Proceedings of the National Academy of Sciences of the United States of America. 111: 8571-6. PMID 24799704 DOI: 10.1073/Pnas.1405153111 |
0.587 |
|
| 2014 |
Wayne AS, Fitzgerald DJ, Kreitman RJ, Pastan I. Immunotoxins for leukemia. Blood. 123: 2470-7. PMID 24578503 DOI: 10.1182/blood-2014-01-492256 |
0.349 |
|
| 2014 |
Terrier B, Nagata S, Ise T, Rosenzwajg M, Pastan I, Klatzmann D, Saadoun D, Cacoub P. CD21(-/low) marginal zone B cells highly express Fc receptor-like 5 protein and are killed by anti-Fc receptor-like 5 immunotoxins in hepatitis C virus-associated mixed cryoglobulinemia vasculitis. Arthritis & Rheumatology (Hoboken, N.J.). 66: 433-43. PMID 24504816 DOI: 10.1002/art.38222 |
0.301 |
|
| 2014 |
Hollevoet K, Antignani A, Fitzgerald DJ, Pastan I. Combining the antimesothelin immunotoxin SS1P with the BH3-mimetic ABT-737 induces cell death in SS1P-resistant pancreatic cancer cells. Journal of Immunotherapy (Hagerstown, Md. : 1997). 37: 8-15. PMID 24316551 DOI: 10.1097/CJI.0000000000000010 |
0.353 |
|
| 2014 |
Liu XF, Xiang L, FitzGerald DJ, Pastan I. Antitumor effects of immunotoxins are enhanced by lowering HCK or treatment with SRC kinase inhibitors. Molecular Cancer Therapeutics. 13: 82-9. PMID 24145282 DOI: 10.1158/1535-7163.MCT-13-0726 |
0.311 |
|
| 2014 |
Ali-Rahmani F, Fitzgerald D, Martin S, Patel P, Thomas C, Pastan I. Abstract 5428: Inhibition of collagen receptor discoidin domain receptor-1 (DDR1) tyrosine kinase enhances cytotoxicity of anti-mesothelin immunotoxin Cancer Research. 74: 5428-5428. DOI: 10.1158/1538-7445.Am2014-5428 |
0.342 |
|
| 2014 |
Niederfellner G, Bauss F, Imhof-Jung S, Hesse F, Kronenberg S, Staak R, Lechmann M, Krippendorff B, Richter W, Mateus R, Kollmorgen G, Brinkmann U, Onda M, Pastan I, Bosslet K. Abstract 4510: RG7787 - a novel de-immunized PE based fusion protein for therapy of mesothelin-positive solid tumors Cancer Research. 74: 4510-4510. DOI: 10.1158/1538-7445.Am2014-4510 |
0.303 |
|
| 2014 |
Pastan I, Hollevoet K, Mason-Osann E, Alewine C, Liu X. Abstract 4505: Anti-tumor activity in pancreatic cancer of a low immunogenic and clinically optimized anti-mesothelin immunotoxin RG7787 Cancer Research. 74: 4505-4505. DOI: 10.1158/1538-7445.Am2014-4505 |
0.343 |
|
| 2014 |
Antignani A, Pasetto M, Choo C, Angelus E, Mathews L, Guha R, Shinn P, Ferrer M, Thomas CJ, Pastan I, Fitzgerald DJ. Abstract 2907: Everolimus enhances the cytotoxic action of the immunotoxin, HA22, directed to CD22 on B-cell malignancies Cancer Research. 74: 2907-2907. DOI: 10.1158/1538-7445.Am2014-2907 |
0.351 |
|
| 2013 |
Hassan R, Miller AC, Sharon E, Thomas A, Reynolds JC, Ling A, Kreitman RJ, Miettinen MM, Steinberg SM, Fowler DH, Pastan I. Major cancer regressions in mesothelioma after treatment with an anti-mesothelin immunotoxin and immune suppression. Science Translational Medicine. 5: 208ra147. PMID 24154601 DOI: 10.1126/scitranslmed.3006941 |
0.338 |
|
| 2013 |
Mattoo AR, Pastan I, Fitzgerald D. Combination treatments with the PKC inhibitor, enzastaurin, enhance the cytotoxicity of the anti-mesothelin immunotoxin, SS1P. Plos One. 8: e75576. PMID 24130723 DOI: 10.1371/journal.pone.0075576 |
0.324 |
|
| 2013 |
Molavi O, Xiong XB, Douglas D, Kneteman N, Nagata S, Pastan I, Chu Q, Lavasanifar A, Lai R. Anti-CD30 antibody conjugated liposomal doxorubicin with significantly improved therapeutic efficacy against anaplastic large cell lymphoma. Biomaterials. 34: 8718-25. PMID 23942212 DOI: 10.1016/J.Biomaterials.2013.07.068 |
0.308 |
|
| 2013 |
Huang YH, Terabe M, Pendleton CD, Stewart Khursigara D, Bera TK, Pastan I, Berzofsky JA. Identification and enhancement of HLA-A2.1-restricted CTL epitopes in a new human cancer antigen-POTE. Plos One. 8: e64365. PMID 23750208 DOI: 10.1371/journal.pone.0064365 |
0.318 |
|
| 2013 |
Choi BD, Pastan I, Bigner DD, Sampson JH. A novel bispecific antibody recruits T cells to eradicate tumors in the "immunologically privileged" central nervous system. Oncoimmunology. 2: e23639. PMID 23734318 DOI: 10.4161/Onci.23639 |
0.319 |
|
| 2013 |
Yamaguchi T, Danjo T, Pastan I, Hikida T, Nakanishi S. Distinct roles of segregated transmission of the septo-habenular pathway in anxiety and fear. Neuron. 78: 537-44. PMID 23602500 DOI: 10.1016/J.Neuron.2013.02.035 |
0.471 |
|
| 2013 |
Wei H, Bera TK, Wayne AS, Xiang L, Colantonio S, Chertov O, Pastan I. A modified form of diphthamide causes immunotoxin resistance in a lymphoma cell line with a deletion of the WDR85 gene. The Journal of Biological Chemistry. 288: 12305-12. PMID 23486472 DOI: 10.1074/jbc.M113.461343 |
0.339 |
|
| 2013 |
Ueno T, Kobayashi N, Nakayama M, Takashima Y, Ohse T, Pastan I, Pippin JW, Shankland SJ, Uesugi N, Matsusaka T, Nagata M. Aberrant Notch1-dependent effects on glomerular parietal epithelial cells promotes collapsing focal segmental glomerulosclerosis with progressive podocyte loss. Kidney International. 83: 1065-75. PMID 23447065 DOI: 10.1038/ki.2013.48 |
0.325 |
|
| 2013 |
Choi BD, Kuan CT, Cai M, Archer GE, Mitchell DA, Gedeon PC, Sanchez-Perez L, Pastan I, Bigner DD, Sampson JH. Systemic administration of a bispecific antibody targeting EGFRvIII successfully treats intracerebral glioma. Proceedings of the National Academy of Sciences of the United States of America. 110: 270-5. PMID 23248284 DOI: 10.1073/Pnas.1219817110 |
0.355 |
|
| 2013 |
Weldon JE, Xiang L, Zhang J, Beers R, Walker DA, Onda M, Hassan R, Pastan I. A recombinant immunotoxin against the tumor-associated antigen mesothelin reengineered for high activity, low off-target toxicity, and reduced antigenicity. Molecular Cancer Therapeutics. 12: 48-57. PMID 23136186 DOI: 10.1158/1535-7163.Mct-12-0336 |
0.341 |
|
| 2013 |
Mattoo AR, Pastan I, Fitzgerald D. Abstract 5490: The cytotoxic activity of the anti-mesothelin immunotoxin SS1P is enhanced by the PKC inhibitor enzastaurin. Cancer Research. 73: 5490-5490. DOI: 10.1158/1538-7445.Am2013-5490 |
0.32 |
|
| 2013 |
Hollevoet K, Antignani A, Fitzgerald DJ, Pastan I. Abstract 5482: Combining the anti-mesothelin immunotoxin SS1P with the BH3-mimetic ABT-737 induces cell death in SS1P-resistant pancreatic cancer cell lines. Cancer Research. 73: 5482-5482. DOI: 10.1158/1538-7445.Am2013-5482 |
0.379 |
|
| 2013 |
Mazor R, Vassall AN, Eberle JA, Beers R, Hu X, Benhar I, Pastan I. Abstract 4334: Identification and elimination of T-cell epitopes in recombinant immunotoxins used to treat cancer. Cancer Research. 73: 4334-4334. DOI: 10.1158/1538-7445.Am2013-4334 |
0.593 |
|
| 2012 |
Mazor R, Vassall AN, Eberle JA, Beers R, Weldon JE, Venzon DJ, Tsang KY, Benhar I, Pastan I. Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A. Proceedings of the National Academy of Sciences of the United States of America. 109: E3597-603. PMID 23213206 DOI: 10.1073/Pnas.1218138109 |
0.596 |
|
| 2012 |
Tortorella LL, Pipalia NH, Mukherjee S, Pastan I, Fitzgerald D, Maxfield FR. Efficiency of immunotoxin cytotoxicity is modulated by the intracellular itinerary. Plos One. 7: e47320. PMID 23056628 DOI: 10.1371/Journal.Pone.0047320 |
0.769 |
|
| 2012 |
Ma J, Tang WK, Esser L, Pastan I, Xia D. Recognition of mesothelin by the therapeutic antibody MORAb-009: structural and mechanistic insights. The Journal of Biological Chemistry. 287: 33123-31. PMID 22787150 DOI: 10.1074/jbc.M112.381756 |
0.333 |
|
| 2012 |
Liu W, Onda M, Lee B, Kreitman RJ, Hassan R, Xiang L, Pastan I. Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes. Proceedings of the National Academy of Sciences of the United States of America. 109: 11782-7. PMID 22753489 DOI: 10.1073/pnas.1209292109 |
0.377 |
|
| 2012 |
Liu XF, Bera TK, Kahue C, Escobar T, Fei Z, Raciti GA, Pastan I. ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells. Plos One. 7: e38130. PMID 22666460 DOI: 10.1371/journal.pone.0038130 |
0.322 |
|
| 2012 |
Pak Y, Zhang Y, Pastan I, Lee B. Antigen shedding may improve efficiencies for delivery of antibody-based anticancer agents in solid tumors. Cancer Research. 72: 3143-52. PMID 22562466 DOI: 10.1158/0008-5472.CAN-11-3925 |
0.326 |
|
| 2012 |
Baskar S, Wiestner A, Wilson WH, Pastan I, Rader C. Targeting malignant B cells with an immunotoxin against ROR1. Mabs. 4: 349-61. PMID 22531447 DOI: 10.4161/Mabs.19870 |
0.353 |
|
| 2012 |
Wei H, Xiang L, Wayne AS, Chertov O, FitzGerald DJ, Bera TK, Pastan I. Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy. Proceedings of the National Academy of Sciences of the United States of America. 109: 6898-903. PMID 22509046 DOI: 10.1073/pnas.1204523109 |
0.321 |
|
| 2012 |
Bera TK, Walker DA, Sherins RJ, Pastan I. POTE protein, a cancer-testis antigen, is highly expressed in spermatids in human testis and is associated with apoptotic cells. Biochemical and Biophysical Research Communications. 417: 1271-4. PMID 22234308 DOI: 10.1016/j.bbrc.2011.12.125 |
0.305 |
|
| 2012 |
Biberacher V, Decker T, Oelsner M, Wagner M, Bogner C, Schmidt B, Kreitman RJ, Peschel C, Pastan I, Meyer Zum Büschenfelde C, Ringshausen I. The cytotoxicity of anti-CD22 immunotoxin is enhanced by bryostatin 1 in B-cell lymphomas through CD22 upregulation and PKC-βII depletion. Haematologica. 97: 771-9. PMID 22180432 DOI: 10.3324/Haematol.2011.049155 |
0.314 |
|
| 2012 |
Liu W, Onda M, Kim C, Xiang L, Weldon JE, Lee B, Pastan I. A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity. Protein Engineering, Design & Selection : Peds. 25: 1-6. PMID 22101015 DOI: 10.1093/Protein/Gzr053 |
0.327 |
|
| 2012 |
Liu XF, Xiang L, Zhang Y, Becker KG, Bera TK, Pastan I. CAPC negatively regulates NF-κB activation and suppresses tumor growth and metastasis. Oncogene. 31: 1673-82. PMID 21822313 DOI: 10.1038/onc.2011.355 |
0.339 |
|
| 2012 |
Haso W, Lee DW, Pastan I, Dimitrov DS, Mackall CL, Orentas RJ. A New High Activity Anti-CD22 Chimeric Antigen Receptor (CAR) Targeting B Cell Leukemia. Blood. 120: 2611-2611. DOI: 10.1182/Blood.V120.21.2611.2611 |
0.316 |
|
| 2012 |
Wei H, Xiang L, Wayne AS, Pastan I. Decreased Expression of Diphthamide Genes Is Responsible for the Resistance to the Anti-CD22 Immunotoxin Moxetumomab Pasudotox (m. pasudotox) in Acute Lymphoblastic Leukemia (ALL)/Non-Hodgkin Lymphoma (NHL) Cell Lines. Blood. 120: 2443-2443. DOI: 10.1182/BLOOD.V120.21.2443.2443 |
0.325 |
|
| 2012 |
Haso W, Lee D, Morgan R, Pastan I, Mackall C, Orentas RJ. Abstract 3504: Generation and optimization of a chimeric antigen receptor against human CD22: A new immunotherapeutic agent for adoptive immunotherapy Cancer Research. 72: 3504-3504. DOI: 10.1158/1538-7445.Am2012-3504 |
0.316 |
|
| 2011 |
Kawa S, Onda M, Ho M, Kreitman RJ, Bera TK, Pastan I. The improvement of an anti-CD22 immunotoxin: conversion to single-chain and disulfide stabilized form and affinity maturation by alanine scan. Mabs. 3: 479-86. PMID 22048691 DOI: 10.4161/mabs.3.5.17228 |
0.313 |
|
| 2011 |
Kreitman RJ, Pastan I. Antibody fusion proteins: anti-CD22 recombinant immunotoxin moxetumomab pasudotox. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 6398-405. PMID 22003067 DOI: 10.1158/1078-0432.CCR-11-0487 |
0.375 |
|
| 2011 |
FitzGerald DJ, Wayne AS, Kreitman RJ, Pastan I. Treatment of hematologic malignancies with immunotoxins and antibody-drug conjugates. Cancer Research. 71: 6300-9. PMID 21998010 DOI: 10.1158/0008-5472.CAN-11-1374 |
0.325 |
|
| 2011 |
Du X, Xiang L, Mackall C, Pastan I. Killing of resistant cancer cells with low Bak by a combination of an antimesothelin immunotoxin and a TRAIL Receptor 2 agonist antibody. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 5926-34. PMID 21813632 DOI: 10.1158/1078-0432.CCR-11-1235 |
0.343 |
|
| 2011 |
Murata K, Imai M, Nakanishi S, Watanabe D, Pastan I, Kobayashi K, Nihira T, Mochizuki H, Yamada S, Mori K, Yamaguchi M. Compensation of depleted neuronal subsets by new neurons in a local area of the adult olfactory bulb. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10540-57. PMID 21775599 DOI: 10.1523/Jneurosci.1285-11.2011 |
0.594 |
|
| 2011 |
Zhang Y, Chertov O, Zhang J, Hassan R, Pastan I. Cytotoxic activity of immunotoxin SS1P is modulated by TACE-dependent mesothelin shedding. Cancer Research. 71: 5915-22. PMID 21775520 DOI: 10.1158/0008-5472.CAN-11-0466 |
0.336 |
|
| 2011 |
Fei Z, Bera TK, Liu X, Xiang L, Pastan I. Ankrd26 gene disruption enhances adipogenesis of mouse embryonic fibroblasts. The Journal of Biological Chemistry. 286: 27761-8. PMID 21669876 DOI: 10.1074/jbc.M111.248435 |
0.319 |
|
| 2011 |
Fitzgerald DJ, Moskatel E, Ben-Josef G, Traini R, Tendler T, Sharma A, Antignani A, Mussai F, Wayne A, Kreitman RJ, Pastan I. Enhancing immunotoxin cell-killing activity via combination therapy with ABT-737. Leukemia & Lymphoma. 52: 79-81. PMID 21599608 DOI: 10.3109/10428194.2011.569961 |
0.371 |
|
| 2011 |
Weldon JE, Pastan I. A guide to taming a toxin--recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer. The Febs Journal. 278: 4683-700. PMID 21585657 DOI: 10.1111/J.1742-4658.2011.08182.X |
0.322 |
|
| 2011 |
Pastan I, Onda M, Weldon J, Fitzgerald D, Kreitman R. Immunotoxins with decreased immunogenicity and improved activity. Leukemia & Lymphoma. 52: 87-90. PMID 21504287 DOI: 10.3109/10428194.2011.573039 |
0.361 |
|
| 2011 |
Onda M, Beers R, Xiang L, Lee B, Weldon JE, Kreitman RJ, Pastan I. Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes. Proceedings of the National Academy of Sciences of the United States of America. 108: 5742-7. PMID 21436054 DOI: 10.1073/Pnas.1102746108 |
0.363 |
|
| 2011 |
Kuan CT, Wakiya K, Keir ST, Li J, Herndon JE, Pastan I, Bigner DD. Affinity-matured anti-glycoprotein NMB recombinant immunotoxins targeting malignant gliomas and melanomas. International Journal of Cancer. Journal International Du Cancer. 129: 111-21. PMID 20824708 DOI: 10.1002/Ijc.25645 |
0.36 |
|
| 2011 |
Ho M, Feng M, Fisher RJ, Rader C, Pastan I. A novel high-affinity human monoclonal antibody to mesothelin. International Journal of Cancer. Journal International Du Cancer. 128: 2020-30. PMID 20635390 DOI: 10.1002/Ijc.25557 |
0.344 |
|
| 2011 |
Lechleider R, Pastan I. Advances in the development of Anti-CD22 immunotoxins containing Pseudomonas exotoxin for treatment of hematologic malignancies Journal of Cancer Science and Therapy. 3: 50-52. DOI: 10.4172/1948-5956.1000057 |
0.334 |
|
| 2011 |
Kreitman RJ, Singh R, Stetler-Stevenson M, Waldmann TA, Pastan I. Regression of Adult T-Cell Leukemia with Anti-CD25 Recombinant Immunotoxin LMB-2 Preceded by Chemotherapy Blood. 118: 2575-2575. DOI: 10.1182/Blood.V118.21.2575.2575 |
0.339 |
|
| 2010 |
Hansen JK, Weldon JE, Xiang L, Beers R, Onda M, Pastan I. A recombinant immunotoxin targeting CD22 with low immunogenicity, low nonspecific toxicity, and high antitumor activity in mice. Journal of Immunotherapy (Hagerstown, Md. : 1997). 33: 297-304. PMID 20445350 DOI: 10.1097/Cji.0B013E3181Cd1164 |
0.346 |
|
| 2010 |
Zhang Y, Hansen JK, Xiang L, Kawa S, Onda M, Ho M, Hassan R, Pastan I. A flow cytometry method to quantitate internalized immunotoxins shows that taxol synergistically increases cellular immunotoxins uptake. Cancer Research. 70: 1082-9. PMID 20103626 DOI: 10.1158/0008-5472.Can-09-2405 |
0.311 |
|
| 2010 |
Bogner C, Dechow T, Ringshausen I, Wagner M, Oelsner M, Lutzny G, Licht T, Peschel C, Pastan I, Kreitman RJ, Decker T. Immunotoxin BL22 induces apoptosis in mantle cell lymphoma (MCL) cells dependent on Bcl-2 expression. British Journal of Haematology. 148: 99-109. PMID 19821820 DOI: 10.1111/j.1365-2141.2009.07939.x |
0.357 |
|
| 2010 |
Pastan I, Roth J, Macchia V. Binding of hormone to tissue: the first step in polypeptide hormone action. Proceedings of the National Academy of Sciences of the United States of America. 56: 1802-9. PMID 16591423 DOI: 10.1073/PNAS.56.6.1802 |
0.353 |
|
| 2010 |
Kreitman RJ, Tallman MS, Coutre S, Robak T, Wilson WH, Stetler-Stevenson M, Noel P, FitzGerald DJ, Buzoianu M, Lechleider RJ, Pastan I. A Phase 1 Study of Moxetumomab Pasudotox, An Anti-CD22 Recombinant Immunotoxin, In Relapsed/Refractory Hairy Cell Leukemia (HCL): Updated Results Blood. 116: 2516-2516. DOI: 10.1182/BLOOD.V116.21.2516.2516 |
0.3 |
|
| 2010 |
Singh R, Zhang YJ, Pastan I, Kreitman RJ. Abstract 5606: Preclinical and clinical development of anti-CD25 recombinant immunotoxin LMB-2 in combination with chemotherapy for the treatment of adult T-cell leukemia Cancer Research. 70: 5606-5606. DOI: 10.1158/1538-7445.Am10-5606 |
0.302 |
|
| 2010 |
Mussai FJ, Campana D, Bhojwani D, Stetler-Stevenson M, Steinberg SM, Morisot S, Civin CI, Wayne AS, Pastan I. Abstract 4356: Cytotoxicity of the anti-CD22 immunotoxin HA22 against pediatric acute lymphoblastic leukemia (ALL) Cancer Research. 70: 4356-4356. DOI: 10.1158/1538-7445.Am10-4356 |
0.316 |
|
| 2009 |
Xiao X, Ho M, Zhu Z, Pastan I, Dimitrov DS. Identification and characterization of fully human anti-CD22 monoclonal antibodies. Mabs. 1: 297-303. PMID 20065646 DOI: 10.4161/mabs.1.3.8113 |
0.333 |
|
| 2009 |
Kreitman RJ, Fitzgerald DJ, Pastan I. Approach to the patient after relapse of hairy cell leukemia. Leukemia & Lymphoma. 50: 32-7. PMID 19814696 DOI: 10.3109/10428190903142216 |
0.323 |
|
| 2009 |
Nagata S, Pastan I. Removal of B cell epitopes as a practical approach for reducing the immunogenicity of foreign protein-based therapeutics. Advanced Drug Delivery Reviews. 61: 977-85. PMID 19679153 DOI: 10.1016/j.addr.2009.07.014 |
0.339 |
|
| 2009 |
Liu XF, Bera TK, Liu LJ, Pastan I. A primate-specific POTE-actin fusion protein plays a role in apoptosis. Apoptosis : An International Journal On Programmed Cell Death. 14: 1237-44. PMID 19669888 DOI: 10.1007/s10495-009-0392-0 |
0.344 |
|
| 2009 |
Ho M, Pastan I. Display and selection of scFv antibodies on HEK-293T cells. Methods in Molecular Biology (Clifton, N.J.). 562: 99-113. PMID 19554290 DOI: 10.1007/978-1-60327-302-2_8 |
0.363 |
|
| 2009 |
Nagata S, Ise T, Pastan I. Fc receptor-like 3 protein expressed on IL-2 nonresponsive subset of human regulatory T cells. Journal of Immunology (Baltimore, Md. : 1950). 182: 7518-26. PMID 19494275 DOI: 10.4049/jimmunol.0802230 |
0.351 |
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| 2009 |
Feng Y, Xiao X, Zhu Z, Streaker E, Ho M, Pastan I, Dimitrov DS. A novel human monoclonal antibody that binds with high affinity to mesothelin-expressing cells and kills them by antibody-dependent cell-mediated cytotoxicity. Molecular Cancer Therapeutics. 8: 1113-8. PMID 19417159 DOI: 10.1158/1535-7163.MCT-08-0945 |
0.355 |
|
| 2009 |
Ho M, Pastan I. In vitro antibody affinity maturation targeting germline hotspots. Methods in Molecular Biology (Clifton, N.J.). 525: 293-308, xiv. PMID 19252855 DOI: 10.1007/978-1-59745-554-1_15 |
0.313 |
|
| 2009 |
Ho M, Pastan I. Mammalian cell display for antibody engineering. Methods in Molecular Biology (Clifton, N.J.). 525: 337-52, xiv. PMID 19252852 DOI: 10.1007/978-1-59745-554-1_18 |
0.35 |
|
| 2009 |
Anaganti S, Hansen JK, Ha D, Hahn Y, Chertov O, Pastan I, Bera TK. Non-AUG translational initiation of a short CAPC transcript generating protein isoform. Biochemical and Biophysical Research Communications. 380: 508-13. PMID 19250639 DOI: 10.1016/J.Bbrc.2009.01.089 |
0.322 |
|
| 2009 |
Carpenito C, Milone MC, Hassan R, Simonet JC, Lakhal M, Suhoski MM, Varela-Rohena A, Haines KM, Heitjan DF, Albelda SM, Carroll RG, Riley JL, Pastan I, June CH. Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains. Proceedings of the National Academy of Sciences of the United States of America. 106: 3360-5. PMID 19211796 DOI: 10.1073/Pnas.0813101106 |
0.343 |
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| 2009 |
Sathyanarayana BK, Hahn Y, Patankar MS, Pastan I, Lee B. Mesothelin, Stereocilin, and Otoancorin are predicted to have superhelical structures with ARM-type repeats. Bmc Structural Biology. 9: 1. PMID 19128473 DOI: 10.1186/1472-6807-9-1 |
0.31 |
|
| 2009 |
Weldon JE, Xiang L, Chertov O, Margulies I, Kreitman RJ, FitzGerald DJ, Pastan I. A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity. Blood. 113: 3792-800. PMID 18988862 DOI: 10.1182/Blood-2008-08-173195 |
0.339 |
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| 2008 |
Laheru DA, Cohen SJ, Phillips M, Armstrong DK, Brahmer J, Jaffee EM, Weil S, Pastan I, Hassan R. A phase I study of MORab-009, a monoclonal antibody against mesothelin, in mesothelioma, pancreatic and ovarian cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 26: 3578. PMID 27949713 DOI: 10.1200/Jco.2008.26.15_Suppl.3578 |
0.353 |
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| 2008 |
Zhang Y, Pastan I. High shed antigen levels within tumors: an additional barrier to immunoconjugate therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 7981-6. PMID 19088013 DOI: 10.1158/1078-0432.CCR-08-0324 |
0.303 |
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| 2008 |
Motoyoshi Y, Matsusaka T, Saito A, Pastan I, Willnow TE, Mizutani S, Ichikawa I. Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuria. Kidney International. 74: 1262-9. PMID 18769366 DOI: 10.1038/ki.2008.405 |
0.304 |
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| 2008 |
Onda M, Beers R, Xiang L, Nagata S, Wang QC, Pastan I. An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes. Proceedings of the National Academy of Sciences of the United States of America. 105: 11311-6. PMID 18678888 DOI: 10.1073/pnas.0804851105 |
0.371 |
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| 2008 |
Das S, Hahn Y, Walker DA, Nagata S, Willingham MC, Peehl DM, Bera TK, Lee B, Pastan I. Topology of NGEP, a prostate-specific cell:cell junction protein widely expressed in many cancers of different grade level. Cancer Research. 68: 6306-12. PMID 18676855 DOI: 10.1158/0008-5472.CAN-08-0870 |
0.347 |
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| 2008 |
Bera TK, Saint Fleur A, Ha D, Yamada M, Lee Y, Lee B, Hahn Y, Kaufman DS, Pera M, Pastan I. Selective POTE paralogs on chromosome 2 are expressed in human embryonic stem cells. Stem Cells and Development. 17: 325-32. PMID 18447647 DOI: 10.1089/Scd.2007.0079 |
0.343 |
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| 2008 |
Epel M, Carmi I, Soueid-Baumgarten S, Oh SK, Bera T, Pastan I, Berzofsky J, Reiter Y. Targeting TARP, a novel breast and prostate tumor-associated antigen, with T cell receptor-like human recombinant antibodies. European Journal of Immunology. 38: 1706-20. PMID 18446790 DOI: 10.1002/eji.200737524 |
0.356 |
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| 2008 |
Levitin F, Weiss M, Hahn Y, Stern O, Papke RL, Matusik R, Nandana SR, Ziv R, Pichinuk E, Salame S, Bera T, Vincent J, Lee B, Pastan I, Wreschner DH. PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activity. The Journal of Biological Chemistry. 283: 16928-39. PMID 18387948 DOI: 10.1074/Jbc.M801454200 |
0.318 |
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| 2008 |
Ise T, Das S, Nagata S, Maeda H, Lee Y, Onda M, Anver MR, Bera TK, Pastan I. Expression of POTE protein in human testis detected by novel monoclonal antibodies. Biochemical and Biophysical Research Communications. 365: 603-8. PMID 17996727 DOI: 10.1016/j.bbrc.2007.10.195 |
0.324 |
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| 2008 |
Du X, Nagata S, Ise T, Stetler-Stevenson M, Pastan I. FCRL1 on chronic lymphocytic leukemia, hairy cell leukemia, and B-cell non-Hodgkin lymphoma as a target of immunotoxins. Blood. 111: 338-43. PMID 17895404 DOI: 10.1182/blood-2007-07-102350 |
0.356 |
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| 2008 |
Kreitman RJ, Wilson WH, Stetler-Stevenson M, Noel P, FitzGerald DJ, Pastan I. Interim Phase I Results of Recombinant Immunotoxin HA22 in Patients with Hairy Cell and Chronic Lymphocytic Leukemias Blood. 112: 3160-3160. DOI: 10.1182/BLOOD.V112.11.3160.3160 |
0.304 |
|
| 2008 |
Nagata S, Ise T, Pastan I. IL-2 non-responsive subset of human natural regulatory T cells expresses Fc receptor-like 3 protein The Faseb Journal. 22: 381-381. DOI: 10.1096/Fasebj.22.2_Supplement.381 |
0.302 |
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| 2007 |
Powell DJ, Felipe-Silva A, Merino MJ, Ahmadzadeh M, Allen T, Levy C, White DE, Mavroukakis S, Kreitman RJ, Rosenberg SA, Pastan I. Administration of a CD25-directed immunotoxin, LMB-2, to patients with metastatic melanoma induces a selective partial reduction in regulatory T cells in vivo. Journal of Immunology (Baltimore, Md. : 1950). 179: 4919-28. PMID 17878392 DOI: 10.4049/Jimmunol.179.7.4919 |
0.301 |
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| 2007 |
Steinbach D, Onda M, Voigt A, Dawczynski K, Wittig S, Hassan R, Gruhn B, Pastan I. Mesothelin, a possible target for immunotherapy, is expressed in primary AML cells. European Journal of Haematology. 79: 281-6. PMID 17803679 DOI: 10.1111/j.1600-0609.2007.00928.x |
0.309 |
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| 2007 |
Du X, Ho M, Pastan I. New immunotoxins targeting CD123, a stem cell antigen on acute myeloid leukemia cells. Journal of Immunotherapy (Hagerstown, Md. : 1997). 30: 607-13. PMID 17667524 DOI: 10.1097/CJI.0b013e318053ed8e |
0.32 |
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| 2007 |
Yokokawa J, Bera TK, Palena C, Cereda V, Remondo C, Gulley JL, Arlen PM, Pastan I, Schlom J, Tsang KY. Identification of cytotoxic T-lymphocyte epitope(s) and its agonist epitope(s) of a novel target for vaccine therapy (PAGE4). International Journal of Cancer. Journal International Du Cancer. 121: 595-605. PMID 17397028 DOI: 10.1002/ijc.22698 |
0.319 |
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| 2007 |
Das S, Hahn Y, Nagata S, Willingham MC, Bera TK, Lee B, Pastan I. NGEP, a prostate-specific plasma membrane protein that promotes the association of LNCaP cells. Cancer Research. 67: 1594-601. PMID 17308099 DOI: 10.1158/0008-5472.CAN-06-2673 |
0.32 |
|
| 2007 |
Pastan I, Hassan R, FitzGerald DJ, Kreitman RJ. Immunotoxin treatment of cancer. Annual Review of Medicine. 58: 221-37. PMID 17059365 DOI: 10.1146/annurev.med.58.070605.115320 |
0.327 |
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| 2007 |
Ahuja Y, Stetler-Stevenson M, Kreitman RJ, Pastan I, Wayne AS. Pre-Clinical Evaluation of the Anti-CD22 Immunotoxin CAT-8015 in Combination with Chemotherapy Agents for Childhood B-Precursor Acute Lymphoblastic Leukemia (Pre-B ALL). Blood. 110: 865-865. DOI: 10.1182/BLOOD.V110.11.865.865 |
0.312 |
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| 2006 |
Onda M, Nagata S, FitzGerald DJ, Beers R, Fisher RJ, Vincent JJ, Lee B, Nakamura M, Hwang J, Kreitman RJ, Hassan R, Pastan I. Characterization of the B cell epitopes associated with a truncated form of Pseudomonas exotoxin (PE38) used to make immunotoxins for the treatment of cancer patients. Journal of Immunology (Baltimore, Md. : 1950). 177: 8822-34. PMID 17142785 DOI: 10.4049/Jimmunol.177.12.8822 |
0.346 |
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| 2006 |
Lee Y, Ise T, Ha D, Saint Fleur A, Hahn Y, Liu XF, Nagata S, Lee B, Bera TK, Pastan I. Evolution and expression of chimeric POTE-actin genes in the human genome. Proceedings of the National Academy of Sciences of the United States of America. 103: 17885-90. PMID 17101985 DOI: 10.1073/pnas.0608344103 |
0.314 |
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| 2006 |
Li Z, Mahesh SP, Shen de F, Liu B, Siu WO, Hwang FS, Wang QC, Chan CC, Pastan I, Nussenblatt RB. Eradication of tumor colonization and invasion by a B cell-specific immunotoxin in a murine model for human primary intraocular lymphoma. Cancer Research. 66: 10586-93. PMID 17079483 DOI: 10.1158/0008-5472.CAN-06-1981 |
0.317 |
|
| 2006 |
Kreitman RJ, Pastan I. Immunotoxins in the treatment of hematologic malignancies. Current Drug Targets. 7: 1301-11. PMID 17073592 DOI: 10.2174/138945006778559139 |
0.362 |
|
| 2006 |
Kreitman RJ, Pastan I. BL22 and lymphoid malignancies. Best Practice & Research. Clinical Haematology. 19: 685-99. PMID 16997177 DOI: 10.1016/j.beha.2006.06.009 |
0.333 |
|
| 2006 |
Kreitman RJ, Pastan I. Immunotoxins in the treatment of refractory hairy cell leukemia. Hematology/Oncology Clinics of North America. 20: 1137-51, viii. PMID 16990113 DOI: 10.1016/j.hoc.2006.06.009 |
0.355 |
|
| 2006 |
Pastan I, Hassan R, Fitzgerald DJ, Kreitman RJ. Immunotoxin therapy of cancer. Nature Reviews. Cancer. 6: 559-65. PMID 16794638 DOI: 10.1038/nrc1891 |
0.329 |
|
| 2006 |
Ho M, Nagata S, Pastan I. Isolation of anti-CD22 Fv with high affinity by Fv display on human cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 9637-42. PMID 16763048 DOI: 10.1073/pnas.0603653103 |
0.376 |
|
| 2006 |
Ise T, Kreitman RJ, Pastan I, Nagata S. Sandwich ELISAs for soluble immunoglobulin superfamily receptor translocation-associated 2 (IRTA2)/FcRH5 (CD307) proteins in human sera. Clinical Chemistry and Laboratory Medicine : Cclm / Fescc. 44: 594-602. PMID 16681430 DOI: 10.1515/CCLM.2006.115 |
0.362 |
|
| 2006 |
Egland KA, Liu XF, Squires S, Nagata S, Man YG, Bera TK, Onda M, Vincent JJ, Strausberg RL, Lee B, Pastan I. High expression of a cytokeratin-associated protein in many cancers. Proceedings of the National Academy of Sciences of the United States of America. 103: 5929-34. PMID 16585525 DOI: 10.1073/Pnas.0601296103 |
0.324 |
|
| 2006 |
Korherr C, Gille H, Schäfer R, Koenig-Hoffmann K, Dixelius J, Egland KA, Pastan I, Brinkmann U. Identification of proangiogenic genes and pathways by high-throughput functional genomics: TBK1 and the IRF3 pathway. Proceedings of the National Academy of Sciences of the United States of America. 103: 4240-5. PMID 16537515 DOI: 10.1073/Pnas.0511319103 |
0.306 |
|
| 2006 |
Attia P, Powell DJ, Maker AV, Kreitman RJ, Pastan I, Rosenberg SA. Selective elimination of human regulatory T lymphocytes in vitro with the recombinant immunotoxin LMB-2. Journal of Immunotherapy (Hagerstown, Md. : 1997). 29: 208-14. PMID 16531821 DOI: 10.1097/01.cji.0000187959.45803.0c |
0.323 |
|
| 2006 |
Hassan R, Remaley AT, Sampson ML, Zhang J, Cox DD, Pingpank J, Alexander R, Willingham M, Pastan I, Onda M. Detection and quantitation of serum mesothelin, a tumor marker for patients with mesothelioma and ovarian cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 447-53. PMID 16428485 DOI: 10.1158/1078-0432.CCR-05-1477 |
0.444 |
|
| 2005 |
Yokokawa J, Palena C, Arlen P, Hassan R, Ho M, Pastan I, Schlom J, Tsang KY. Identification of novel human CTL epitopes and their agonist epitopes of mesothelin. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 6342-51. PMID 16144939 DOI: 10.1158/1078-0432.CCR-05-0596 |
0.348 |
|
| 2005 |
Onda M, Willingham M, Nagata S, Bera TK, Beers R, Ho M, Hassan R, Kreitman RJ, Pastan I. New monoclonal antibodies to mesothelin useful for immunohistochemistry, fluorescence-activated cell sorting, Western blotting, and ELISA. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 5840-6. PMID 16115924 DOI: 10.1158/1078-0432.CCR-05-0578 |
0.358 |
|
| 2005 |
Hassan R, Kreitman RJ, Pastan I, Willingham MC. Localization of mesothelin in epithelial ovarian cancer. Applied Immunohistochemistry & Molecular Morphology : Aimm / Official Publication of the Society For Applied Immunohistochemistry. 13: 243-7. PMID 16082249 DOI: 10.1097/01.pai.00000141545.36485.d6 |
0.306 |
|
| 2005 |
Asano T, Niimura F, Pastan I, Fogo AB, Ichikawa I, Matsusaka T. Permanent genetic tagging of podocytes: fate of injured podocytes in a mouse model of glomerular sclerosis. Journal of the American Society of Nephrology : Jasn. 16: 2257-62. PMID 15987751 DOI: 10.1681/ASN.2004121134 |
0.303 |
|
| 2005 |
Soler-GarcÃa AA, Maitra R, Kumar V, Ise T, Nagata S, Beers R, Bera TK, Pastan I. The PATE gene is expressed in the accessory tissues of the human male genital tract and encodes a secreted sperm-associated protein. Reproduction (Cambridge, England). 129: 515-24. PMID 15798027 DOI: 10.1530/rep.1.00576 |
0.329 |
|
| 2005 |
Bang S, Nagata S, Onda M, Kreitman RJ, Pastan I. HA22 (R490A) is a recombinant immunotoxin with increased antitumor activity without an increase in animal toxicity. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 1545-50. PMID 15746059 DOI: 10.1158/1078-0432.CCR-04-1939 |
0.302 |
|
| 2005 |
Ho M, Kreitman RJ, Onda M, Pastan I. In vitro antibody evolution targeting germline hot spots to increase activity of an anti-CD22 immunotoxin. The Journal of Biological Chemistry. 280: 607-17. PMID 15491997 DOI: 10.1074/jbc.M409783200 |
0.34 |
|
| 2004 |
Hassan R, Bera T, Pastan I. Mesothelin: a new target for immunotherapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 3937-42. PMID 15217923 DOI: 10.1158/1078-0432.CCR-03-0801 |
0.343 |
|
| 2004 |
Maeda H, Nagata S, Wolfgang CD, Bratthauer GL, Bera TK, Pastan I. The T cell receptor gamma chain alternate reading frame protein (TARP), a prostate-specific protein localized in mitochondria. The Journal of Biological Chemistry. 279: 24561-8. PMID 15150260 DOI: 10.1074/jbc.M402492200 |
0.335 |
|
| 2004 |
FitzGerald DJ, Kreitman R, Wilson W, Squires D, Pastan I. Recombinant immunotoxins for treating cancer. International Journal of Medical Microbiology : Ijmm. 293: 577-82. PMID 15149034 DOI: 10.1078/1438-4221-00302 |
0.397 |
|
| 2004 |
Oh S, Terabe M, Pendleton CD, Bhattacharyya A, Bera TK, Epel M, Reiter Y, Phillips J, Linehan WM, Kasten-Sportes C, Pastan I, Berzofsky JA. Human CTLs to wild-type and enhanced epitopes of a novel prostate and breast tumor-associated protein, TARP, lyse human breast cancer cells. Cancer Research. 64: 2610-8. PMID 15059918 DOI: 10.1158/0008-5472.Can-03-2183 |
0.324 |
|
| 2004 |
Onda M, Wang QC, Guo HF, Cheung NK, Pastan I. In vitro and in vivo cytotoxic activities of recombinant immunotoxin 8H9(Fv)-PE38 against breast cancer, osteosarcoma, and neuroblastoma. Cancer Research. 64: 1419-24. PMID 14973056 DOI: 10.1158/0008-5472.Can-03-0570 |
0.301 |
|
| 2004 |
Hassan R, Williams-Gould J, Watson T, Pai-Scherf L, Pastan I. Pretreatment with rituximab does not inhibit the human immune response against the immunogenic protein LMB-1. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 16-8. PMID 14734446 DOI: 10.1158/1078-0432.Ccr-1160-3 |
0.313 |
|
| 2004 |
Decker T, Oelsner M, Kreitman RJ, Salvatore G, Wang QC, Pastan I, Peschel C, Licht T. Induction of caspase-dependent programmed cell death in B-cell chronic lymphocytic leukemia by anti-CD22 immunotoxins. Blood. 103: 2718-26. PMID 14525789 DOI: 10.1182/blood-2003-04-1317 |
0.315 |
|
| 2004 |
Hassan R, Bullock S, Kreitman RJ, Kindler HL, Pastan I. Targeted therapy of mesothelin expressing mesotheliomas (MM), ovarian cancer (OC) and pancreatic cancer (PC): Results of phase I study of SS1(dsFv)PE38 (SS1P) Journal of Clinical Oncology. 22: 3035-3035. DOI: 10.1200/JCO.2004.22.90140.3035 |
0.302 |
|
| 2004 |
Decker T, Wagner M, Oelsner M, Kreitman RJ, Pastan I, Peschel C, Licht T. BL22, a Recombinant Anti-CD22 Immunotoxin, Induces Cell Cycle Arrest and Apoptosis in B-Cell Lymphoma. Blood. 104: 4613-4613. DOI: 10.1182/BLOOD.V104.11.4613.4613 |
0.365 |
|
| 2004 |
Ise T, Nagata S, Maeda H, Kreitman R, Stetler-Stevenson M, Pastan I. IRTA2 Protein on Lymphoma Cell Lines and Hairy Cell Leukemia Cells Detected by Novel Monoclonal Antibodies. Blood. 104: 1101-1101. DOI: 10.1182/BLOOD.V104.11.1101.1101 |
0.385 |
|
| 2003 |
Sampson JH, Akabani G, Archer GE, Bigner DD, Berger MS, Friedman AH, Friedman HS, Herndon JE, Kunwar S, Marcus S, McLendon RE, Paolino A, Penne K, Provenzale J, Quinn J, ... ... Pastan I, et al. Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malignant brain tumors. Journal of Neuro-Oncology. 65: 27-35. PMID 14649883 DOI: 10.1023/A:1026290315809 |
0.363 |
|
| 2003 |
Brinkmann U, Mansfield E, Pastan I. Effects of BCL-2 overexpression on the sensitivity of MCF-7 breast cancer cells to ricin, diphtheria and Pseudomonas toxin and immunotoxins. Apoptosis : An International Journal On Programmed Cell Death. 2: 192-8. PMID 14646554 DOI: 10.1023/A:1026468532413 |
0.342 |
|
| 2003 |
Gupta A, Onda M, Pastan I, Adhya S, Chaudhary VK. High-density functional display of proteins on bacteriophage lambda. Journal of Molecular Biology. 334: 241-54. PMID 14607116 DOI: 10.1016/J.Jmb.2003.09.033 |
0.309 |
|
| 2003 |
Nagata S, Salvatore G, Pastan I. DNA immunization followed by a single boost with cells: a protein-free immunization protocol for production of monoclonal antibodies against the native form of membrane proteins. Journal of Immunological Methods. 280: 59-72. PMID 12972188 DOI: 10.1016/S0022-1759(03)00192-3 |
0.36 |
|
| 2003 |
Soda T, Nakashima R, Watanabe D, Nakajima K, Pastan I, Nakanishi S. Segregation and coactivation of developing neocortical layer 1 neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 6272-9. PMID 12867512 DOI: 10.1523/Jneurosci.23-15-06272.2003 |
0.567 |
|
| 2003 |
Cheng WS, Giandomenico V, Pastan I, Essand M. Characterization of the androgen-regulated prostate-specific T cell receptor gamma-chain alternate reading frame protein (TARP) promoter. Endocrinology. 144: 3433-40. PMID 12865322 DOI: 10.1210/en.2003-0121 |
0.301 |
|
| 2003 |
Kitabatake Y, Hikida T, Watanabe D, Pastan I, Nakanishi S. Impairment of reward-related learning by cholinergic cell ablation in the striatum. Proceedings of the National Academy of Sciences of the United States of America. 100: 7965-70. PMID 12802017 DOI: 10.1073/Pnas.1032899100 |
0.578 |
|
| 2003 |
Hikida T, Kitabatake Y, Pastan I, Nakanishi S. Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine. Proceedings of the National Academy of Sciences of the United States of America. 100: 6169-73. PMID 12721372 DOI: 10.1073/Pnas.0631749100 |
0.467 |
|
| 2003 |
Pastan I. Immunotoxins containing Pseudomonas exotoxin A: a short history. Cancer Immunology, Immunotherapy : Cii. 52: 338-41. PMID 12700949 DOI: 10.1007/s00262-002-0353-8 |
0.393 |
|
| 2003 |
Kreitman RJ, Pastan I. Immunobiological treatments of hairy-cell leukaemia. Best Practice & Research. Clinical Haematology. 16: 117-33. PMID 12670470 DOI: 10.1016/S1521-6926(03)00003-3 |
0.317 |
|
| 2002 |
Hirano T, Watanabe D, Kawaguchi SY, Pastan I, Nakanishi S. Roles of inhibitory interneurons in the cerebellar cortex. Annals of the New York Academy of Sciences. 978: 405-12. PMID 12582069 DOI: 10.1111/J.1749-6632.2002.Tb07583.X |
0.614 |
|
| 2002 |
McHugh L, Hu S, Lee BK, Santora K, Kennedy PE, Berger EA, Pastan I, Hamer DH. Increased affinity and stability of an anti-HIV-1 envelope immunotoxin by structure-based mutagenesis. The Journal of Biological Chemistry. 277: 34383-90. PMID 12119300 DOI: 10.1074/jbc.M205456200 |
0.331 |
|
| 2002 |
Salvatore G, Nagata S, Billaud M, Santoro M, Vecchio G, Pastan I. Generation and characterization of novel monoclonal antibodies to the Ret receptor tyrosine kinase. Biochemical and Biophysical Research Communications. 294: 813-7. PMID 12061779 DOI: 10.1016/S0006-291X(02)00560-0 |
0.323 |
|
| 2002 |
Bera TK, Iavarone C, Kumar V, Lee S, Lee B, Pastan I. MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 99: 6997-7002. PMID 12011458 DOI: 10.1073/pnas.102187299 |
0.305 |
|
| 2002 |
Hazama M, Watanabe D, Suzuki M, Mizoguchi A, Pastan I, Nakanishi S. Different regulatory sequences are required for parvalbumin gene expression in skeletal muscles and neuronal cells of transgenic mice. Brain Research. Molecular Brain Research. 100: 53-66. PMID 12008021 DOI: 10.1016/S0169-328X(02)00142-0 |
0.604 |
|
| 2002 |
Decker T, Hipp S, Kreitman RJ, Pastan I, Peschel C, Licht T. Sensitization of B-cell chronic lymphocytic leukemia cells to recombinant immunotoxin by immunostimulatory phosphorothioate oligodeoxynucleotides. Blood. 99: 1320-6. PMID 11830482 DOI: 10.1182/blood.V99.4.1320 |
0.332 |
|
| 2002 |
Shinohara H, Morita S, Kawai M, Miyamoto A, Sonoda T, Pastan I, Tanigawa N. Expression of HER2 in human gastric cancer cells directly correlates with antitumor activity of a recombinant disulfide-stabilized anti-HER2 immunotoxin. The Journal of Surgical Research. 102: 169-77. PMID 11796015 DOI: 10.1006/jsre.2001.6305 |
0.358 |
|
| 2001 |
Hikida T, Kaneko S, Isobe T, Kitabatake Y, Watanabe D, Pastan I, Nakanishi S. Increased sensitivity to cocaine by cholinergic cell ablation in nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America. 98: 13351-4. PMID 11606786 DOI: 10.1073/Pnas.231488998 |
0.566 |
|
| 2001 |
Kobayashi T, Kida Y, Kaneko T, Pastan I, Kobayashi K. Efficient ablation by immunotoxin-mediated cell targeting of the cell types that express human interleukin-2 receptor depending on the internal ribosome entry site. The Journal of Gene Medicine. 3: 505-10. PMID 11601764 DOI: 10.1002/jgm.208 |
0.332 |
|
| 2001 |
Bera TK, Bera J, Brinkmann U, Tessarollo L, Pastan I. Cse1l is essential for early embryonic growth and development. Molecular and Cellular Biology. 21: 7020-4. PMID 11564884 DOI: 10.1128/MCB.21.20.7020-7024.2001 |
0.302 |
|
| 2001 |
Kreitman RJ, Wilson WH, Bergeron K, Raggio M, Stetler-Stevenson M, FitzGerald DJ, Pastan I. Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia. The New England Journal of Medicine. 345: 241-7. PMID 11474661 DOI: 10.1056/NEJM200107263450402 |
0.332 |
|
| 2001 |
Onda M, Olafsen T, Tsutsumi Y, Bruland ØS, Pastan I. Cytotoxicity of Antiosteosarcoma Recombinant Immunotoxins Composed of TP-3 Fv Fragments and a Truncated Pseudomonas Exotoxin A. Journal of Immunotherapy : Official Journal of the Society For Biological Therapy. 24: 144-150. PMID 11449071 DOI: 10.1097/00002371-200103000-00009 |
0.366 |
|
| 2001 |
Yoshida K, Watanabe D, Ishikane H, Tachibana M, Pastan I, Nakanishi S. A key role of starburst amacrine cells in originating retinal directional selectivity and optokinetic eye movement. Neuron. 30: 771-80. PMID 11430810 DOI: 10.1016/S0896-6273(01)00316-6 |
0.595 |
|
| 2001 |
Lee CG, Vieira WD, Pastan I, Gottesman MM. An episomally maintained MDR1 gene for gene therapy. Human Gene Therapy. 12: 945-53. PMID 11387059 DOI: 10.1089/104303401750195908 |
0.342 |
|
| 2001 |
Rozemuller H, Chowdhury PS, Pastan I, Kreitman RJ. Isolation of new anti-CD30 scFvs from DNA-immunized mice by phage display and biologic activity of recombinant immunotoxins produced by fusion with truncated pseudomonas exotoxin. International Journal of Cancer. Journal International Du Cancer. 92: 861-70. PMID 11351308 DOI: 10.1002/ijc.1266 |
0.304 |
|
| 2000 |
Kreitman RJ, Pastan I. 12 making fusion toxins to target leukemia and lymphoma. Methods in Molecular Medicine. 25: 215-26. PMID 21318848 DOI: 10.1385/1-59259-075-6:215 |
0.36 |
|
| 2000 |
Kuan CT, Wikstrand CJ, Archer G, Beers R, Pastan I, Zalutsky MR, Bigner DD. Increased binding affinity enhances targeting of glioma xenografts by EGFRvIII-specific scFv. International Journal of Cancer. Journal International Du Cancer. 88: 962-9. PMID 11093822 DOI: 10.1002/1097-0215(20001215)88:6<962::Aid-Ijc20>3.0.Co;2-U |
0.315 |
|
| 2000 |
Wolfgang CD, Essand M, Vincent JJ, Lee B, Pastan I. TARP: a nuclear protein expressed in prostate and breast cancer cells derived from an alternate reading frame of the T cell receptor gamma chain locus. Proceedings of the National Academy of Sciences of the United States of America. 97: 9437-42. PMID 10931945 DOI: 10.1073/pnas.160270597 |
0.334 |
|
| 2000 |
Hassan R, Viner JL, Wang QC, Margulies I, Kreitman RJ, Pastan I. Anti-tumor activity of K1-LysPE38QQR, an immunotoxin targeting mesothelin, a cell-surface antigen overexpressed in ovarian cancer and malignant mesothelioma. Journal of Immunotherapy (Hagerstown, Md. : 1997). 23: 473-9. PMID 10916757 DOI: 10.1097/00002371-200007000-00011 |
0.36 |
|
| 2000 |
Kaneko S, Hikida T, Watanabe D, Ichinose H, Nagatsu T, Kreitman RJ, Pastan I, Nakanishi S. Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function. Science (New York, N.Y.). 289: 633-7. PMID 10915629 DOI: 10.1126/Science.289.5479.633 |
0.588 |
|
| 2000 |
Tsutsumi Y, Onda M, Nagata S, Lee B, Kreitman RJ, Pastan I. Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity. Proceedings of the National Academy of Sciences of the United States of America. 97: 8548-53. PMID 10890891 DOI: 10.1073/pnas.140210597 |
0.331 |
|
| 2000 |
Keppler-Hafkemeyer A, Kreitman RJ, Pastan I. Apoptosis induced by immunotoxins used in the treatment of hematologic malignancies. International Journal of Cancer. Journal International Du Cancer. 87: 86-94. PMID 10861457 DOI: 10.1002/1097-0215(20000701)87:1<86::AID-IJC13>3.0.CO;2-I |
0.342 |
|
| 2000 |
Hafkemeyer P, Licht T, Pastan I, Gottesman MM. Chemoprotection of hematopoietic cells by a mutant P-glycoprotein resistant to a potent chemosensitizer of multidrug-resistant cancers. Human Gene Therapy. 11: 555-65. PMID 10724034 DOI: 10.1089/10430340050015743 |
0.318 |
|
| 2000 |
Shen DW, Goldenberg S, Pastan I, Gottesman MM. Decreased accumulation of [14C]carboplatin in human cisplatin-resistant cells results from reduced energy-dependent uptake. Journal of Cellular Physiology. 183: 108-16. PMID 10699972 DOI: 10.1002/(Sici)1097-4652(200004)183:1<108::Aid-Jcp13>3.0.Co;2-4 |
0.341 |
|
| 2000 |
Licht T, Goldenberg SK, Vieira WD, Gottesman MM, Pastan I. Drug selection of MDR1-transduced hematopoietic cells ex vivo increases transgene expression and chemoresistance in reconstituted bone marrow in mice. Gene Therapy. 7: 348-58. PMID 10694816 DOI: 10.1038/Sj.Gt.3301087 |
0.321 |
|
| 2000 |
Yerushalmi N, Brinkmann U, Brinkmann E, Pai L, Pastan I. Attenuating the growth of tumors by intratumoral administration of DNA encoding Pseudomonas exotoxin via cationic liposomes. Cancer Gene Therapy. 7: 91-6. PMID 10678361 DOI: 10.1038/sj.cgt.7700115 |
0.316 |
|
| 1999 |
Chowdhury PS, Pastan I. Analysis of cloned Fvs from a phage display library indicates that DNA immunization can mimic antibody response generated by cell immunizations. Journal of Immunological Methods. 231: 83-91. PMID 10648929 DOI: 10.1016/S0022-1759(99)00142-8 |
0.323 |
|
| 1999 |
Adobati E, Zacchetti A, Perico ME, Cremonesi F, Rasi G, Vallebona PS, Hagenaars M, Kuppen PJ, Pastan I, Panza L, Russo G, Colnaghi MI, Canevari S. Expression profile of saccharide epitope CaMBr1 in normal and neoplastic tissue from dogs, cats, and rats: implication for the development of human-derived cancer vaccines. The Histochemical Journal. 31: 729-37. PMID 10646838 DOI: 10.1023/A:1003900631953 |
0.306 |
|
| 1999 |
Kreitman RJ, Wilson WH, Robbins D, Margulies I, Stetler-Stevenson M, Waldmann TA, Pastan I. Responses in refractory hairy cell leukemia to a recombinant immunotoxin. Blood. 94: 3340-8. PMID 10552943 DOI: 10.1182/Blood.V94.10.3340.422K19_3340_3348 |
0.32 |
|
| 1999 |
Licht T, Aran JM, Goldenberg SK, Vieira WD, Gottesman MM, Pastan I. Retroviral transfer of human MDR1 gene to hematopoietic cells: effects of drug selection and of transcript splicing on expression of encoded P-glycoprotein. Human Gene Therapy. 10: 2173-85. PMID 10498249 DOI: 10.1089/10430349950017167 |
0.347 |
|
| 1999 |
Chowdhury PS, Pastan I. Improving antibody affinity by mimicking somatic hypermutation in vitro. Nature Biotechnology. 17: 568-72. PMID 10385321 DOI: 10.1038/9872 |
0.307 |
|
| 1999 |
Hafkemeyer P, Brinkmann U, Gottesman MM, Pastan I. Apoptosis induced by Pseudomonas exotoxin: a sensitive and rapid marker for gene delivery in vivo. Human Gene Therapy. 10: 923-34. PMID 10223726 DOI: 10.1089/10430349950018328 |
0.304 |
|
| 1999 |
Friedrich K, Wietek S, Lischke A, Wellbrock C, Kreitman RJ, Pastan I, Sebald W. A two-step selection approach for the identification of ligand-binding determinants in cytokine receptors Analytical Biochemistry. 268: 179-186. PMID 10075806 DOI: 10.1006/abio.1998.3078 |
0.326 |
|
| 1999 |
Hassan R, Wu C, Brechbiel MW, Margulies I, Kreitman RJ, Pastan I. 111Indium-labeled monoclonal antibody K1: Biodistribution study in nude mice bearing a human carcinoma xenograft expressing mesothelin International Journal of Cancer. 80: 559-563. PMID 9935157 DOI: 10.1002/(SICI)1097-0215(19990209)80:4<559::AID-IJC13>3.0.CO;2-Y |
0.307 |
|
| 1999 |
Reiter Y, Pastan I. Recombinant Fv immunotoxins and Fv fragments as novel agents for cancer therapy and diagnosis. Trends in Biotechnology. 16: 513-20. PMID 9881483 DOI: 10.1016/S0167-7799(98)01226-8 |
0.333 |
|
| 1999 |
Moscow JA, Huang H, Carter C, Hines K, Zujewski J, Cusack G, Chow C, Venzon D, Sorrentino B, Chiang Y, Goldspiel B, Leitman S, Read EJ, Abati A, Gottesman MM, ... Pastan I, et al. Engraftment of MDR1 and NeoR Gene-Transduced Hematopoietic Cells After Breast Cancer Chemotherapy Blood. 94: 52-61. DOI: 10.1182/Blood.V94.1.52.413K35_52_61 |
0.312 |
|
| 1998 |
PASTAN I. Certain functions of isolated thyroid cells. Endocrinology. 68: 924-31. PMID 13733193 DOI: 10.1210/ENDO-68-6-924 |
0.305 |
|
| 1998 |
Pastan I, Kreitman RJ. Immunotoxins for targeted cancer therapy. Advanced Drug Delivery Reviews. 31: 53-88. PMID 10837618 DOI: 10.1016/S0169-409X(97)00094-X |
0.361 |
|
| 1998 |
Bera TK, Pastan I. Comparison of recombinant immunotoxins against LeY antigen expressing tumor cells: influence of affinity, size, and stability. Bioconjugate Chemistry. 9: 736-43. PMID 9815167 DOI: 10.1021/bc980028o |
0.344 |
|
| 1998 |
Watanabe D, Inokawa H, Hashimoto K, Suzuki N, Kano M, Shigemoto R, Hirano T, Toyama K, Kaneko S, Yokoi M, Moriyoshi K, Suzuki M, Kobayashi K, Nagatsu T, Kreitman RJ, ... Pastan I, et al. Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination. Cell. 95: 17-27. PMID 9778244 DOI: 10.1016/S0092-8674(00)81779-1 |
0.689 |
|
| 1998 |
Hrycyna CA, Airan LE, Germann UA, Ambudkar SV, Pastan I, Gottesman MM. Structural flexibility of the linker region of human P-glycoprotein permits ATP hydrolysis and drug transport. Biochemistry. 37: 13660-73. PMID 9753453 DOI: 10.1021/Bi9808823 |
0.333 |
|
| 1998 |
Lee CG, Pastan I, Gottesman MM. Retroviral transfer of human MDR1 gene into human T lymphocytes. Methods in Enzymology. 292: 557-72. PMID 9711583 DOI: 10.1016/S0076-6879(98)92044-4 |
0.36 |
|
| 1998 |
Licht T, Gottesman MM, Pastan I. Retroviral transfer of multidrug transporter to murine hematopoietic stem cells. Methods in Enzymology. 292: 546-57. PMID 9711582 DOI: 10.1016/S0076-6879(98)92043-2 |
0.314 |
|
| 1998 |
Sugimoto Y, Gottesman MM, Pastan I, Tsuruo T. Construction of MDR1 vectors for gene therapy. Methods in Enzymology. 292: 523-37. PMID 9711580 DOI: 10.1016/S0076-6879(98)92041-9 |
0.314 |
|
| 1998 |
Zhang S, Sugimoto Y, Shoshani T, Pastan I, Gottesman MM. pHaMDR-DHFR bicistronic expression system for mutational analysis of P-glycoprotein. Methods in Enzymology. 292: 474-80. PMID 9711575 DOI: 10.1016/S0076-6879(98)92036-5 |
0.312 |
|
| 1998 |
Hrycyna CA, Ramachandra M, Pastan I, Gottesman MM. Functional expression of human P-glycoprotein from plasmids using vaccinia virus-bacteriophage T7 RNA polymerase system. Methods in Enzymology. 292: 456-73. PMID 9711574 DOI: 10.1016/S0076-6879(98)92035-3 |
0.328 |
|
| 1998 |
Ramachandra M, Gottesman MM, Pastan I. Recombinant vaccinia virus vectors for functional expression of P-glycoprotein in mammalian cells. Methods in Enzymology. 292: 441-55. PMID 9711573 DOI: 10.1016/S0076-6879(98)92034-1 |
0.325 |
|
| 1998 |
Dey S, Ramachandra M, Pastan I, Gottesman MM, Ambudkar SV. Photoaffinity labeling of human P-glycoprotein: effect of modulator interaction and ATP hydrolysis on substrate binding. Methods in Enzymology. 292: 318-28. PMID 9711564 DOI: 10.1016/S0076-6879(98)92025-0 |
0.31 |
|
| 1998 |
Kobayashi H, Han ES, Kim IS, Le N, Rajagopal V, Kreitman RJ, Pastan I, Paik CH, Carrasquillo JA. Similarities in the biodistribution of iodine-labeled anti-Tac single-chain disulfide-stabilized Fv fragment and anti-Tac disulfide-stabilized Fv fragment. Nuclear Medicine and Biology. 25: 387-93. PMID 9639301 DOI: 10.1016/S0969-8051(97)00228-X |
0.316 |
|
| 1998 |
Reiter Y, Brinkmann U, Lee B, Pastan I. Engineering antibody Fv fragments for cancer detection and therapy: disulfide-stabilized Fv fragments. Nature Biotechnology. 14: 1239-45. PMID 9631086 DOI: 10.1038/NBT1096-1239 |
0.309 |
|
| 1998 |
Almog O, Benhar I, Vasmatzis G, Tordova M, Lee B, Pastan I, Gilliland GL. Crystal structure of the disulfide-stabilized Fv fragment of anticancer antibody B1: conformational influence of an engineered disulfide bond. Proteins. 31: 128-38. PMID 9593187 DOI: 10.1002/(Sici)1097-0134(19980501)31:2<128::Aid-Prot3>3.0.Co;2-I |
0.574 |
|
| 1998 |
Zhou Y, Aran J, Gottesman MM, Pastan I. Co-expression of human adenosine deaminase and multidrug resistance using a bicistronic retroviral vector. Human Gene Therapy. 9: 287-93. PMID 9508046 DOI: 10.1089/Hum.1998.9.3-287 |
0.314 |
|
| 1998 |
Sawada H, Nishii K, Suzuki T, Hasegawa K, Hata T, Nagatsu I, Kreitman RJ, Pastan I, Nagatsu T, Kobayashi K. Autonomic neuropathy in transgenic mice caused by immunotoxin targeting of the peripheral nervous system Journal of Neuroscience Research. 51: 162-173. PMID 9469570 DOI: 10.1002/(SICI)1097-4547(19980115)51:2<162::AID-JNR5>3.0.CO;2-B |
0.319 |
|
| 1998 |
Chowdhury PS, Viner JL, Beers R, Pastan I. Isolation of a high-affinity stable single-chain Fv specific for mesothelin from DNA-immunized mice by phage display and construction of a recombinant immunotoxin with anti-tumor activity. Proceedings of the National Academy of Sciences of the United States of America. 95: 669-74. PMID 9435250 DOI: 10.1073/Pnas.95.2.669 |
0.375 |
|
| 1997 |
Rajagopal V, Pastan I, Kreitman RJ. A form of anti-Tac(Fv) which is both single-chain and disulfide stabilized: comparison with its single-chain and disulfide-stabilized homologs. Protein Engineering. 10: 1453-9. PMID 9543007 DOI: 10.1093/PROTEIN/10.12.1453 |
0.309 |
|
| 1997 |
Lee CG, Jeang KT, Martin MA, Pastan I, Gottesman MM. Efficient long-term coexpression of a hammerhead ribozyme targeted to the U5 region of HIV-1 LTR by linkage to the multidrug-resistance gene. Antisense & Nucleic Acid Drug Development. 7: 511-22. PMID 9361910 DOI: 10.1089/Oli.1.1997.7.511 |
0.315 |
|
| 1997 |
Rozemuller H, Rombouts EJC, Touw IP, Fitzgerald DJP, Kreitman RJ, Pastan I, Hagenbeek A, Martens ACM. Sensitivity of human acute myeloid leukaemia to diphtheria toxin-GM-CSF fusion protein British Journal of Haematology. 98: 952-959. PMID 9326195 DOI: 10.1046/J.1365-2141.1997.2893106.X |
0.316 |
|
| 1997 |
Funatomi H, Itakura J, Ishiwata T, Pastan I, Thompson SA, Johnson GR, Korc M. Amphiregulin antisense oligonucleotide inhibits the growth of T3M4 human pancreatic cancer cells and sensitizes the cells to EGF receptor-targeted therapy. International Journal of Cancer. 72: 512-7. PMID 9247297 DOI: 10.1002/(Sici)1097-0215(19970729)72:3<512::Aid-Ijc21>3.0.Co;2-C |
0.345 |
|
| 1997 |
Chowdhury PS, Chang K, Pastan I. Isolation of anti-mesothelin antibodies from a phage display library. Molecular Immunology. 34: 9-20. PMID 9182872 DOI: 10.1016/S0161-5890(97)00011-4 |
0.341 |
|
| 1997 |
Brinkmann U, Webber K, Di Carlo A, Beers R, Chowdhury P, Chang K, Chaudhary V, Gallo M, Pastan I. Cloning and expression of the recombinant FAb fragment of monoclonal antibody K1 that reacts with mesothelin present on mesotheliomas and ovarian cancers. International Journal of Cancer. 71: 638-44. PMID 9178820 DOI: 10.1002/(SICI)1097-0215(19970516)71:4<638::AID-IJC21>3.0.CO;2-6 |
0.304 |
|
| 1997 |
Reiter Y, Di Carlo A, Fugger L, Engberg J, Pastan I. Peptide-specific killing of antigen-presenting cells by a recombinant antibody-toxin fusion protein targeted to major histocompatibility complex/peptide class I complexes with T cell receptor-like specificity. Proceedings of the National Academy of Sciences of the United States of America. 94: 4631-6. PMID 9114042 DOI: 10.1073/PNAS.94.9.4631 |
0.33 |
|
| 1997 |
Licht T, Herrmann F, Gottesman MM, Pastan I. In vivo drug-selectable genes: a new concept in gene therapy. Stem Cells (Dayton, Ohio). 15: 104-11. PMID 9090786 DOI: 10.1002/Stem.150104 |
0.318 |
|
| 1997 |
Aran JM, Licht T, Gottesman MM, Pastan I. Complete restoration of glucocerebrosidase deficiency in Gaucher fibroblasts using a bicistronic MDR retrovirus and a new selection strategy. Human Gene Therapy. 7: 2165-75. PMID 8934230 DOI: 10.1089/Hum.1996.7.17-2165 |
0.314 |
|
| 1997 |
Mansfield E, Amlot P, Pastan I, FitzGerald DJ. Recombinant RFB4 Immunotoxins Exhibit Potent Cytotoxic Activity for CD22-Bearing Cells and Tumors Blood. 90: 2020-2026. DOI: 10.1182/Blood.V90.5.2020 |
0.324 |
|
| 1997 |
Kreitman RJ, Pastan I. Recombinant Toxins Containing Human Granulocyte-Macrophage Colony-Stimulating Factor and Either Pseudomonas Exotoxin or Diphtheria Toxin Kill Gastrointestinal Cancer and Leukemia Cells Blood. 90: 252-259. DOI: 10.1182/blood.v90.1.252 |
0.367 |
|
| 1996 |
Lorimer IA, Keppler-Hafkemeyer A, Beers RA, Pegram CN, Bigner DD, Pastan I. Recombinant immunotoxins specific for a mutant epidermal growth factor receptor: targeting with a single chain antibody variable domain isolated by phage display. Proceedings of the National Academy of Sciences of the United States of America. 93: 14815-20. PMID 8962138 DOI: 10.1073/pnas.93.25.14815 |
0.356 |
|
| 1996 |
Ramachandra M, Ambudkar SV, Gottesman MM, Pastan I, Hrycyna CA. Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system. Molecular Biology of the Cell. 7: 1485-98. PMID 8898356 DOI: 10.1091/Mbc.7.10.1485 |
0.338 |
|
| 1996 |
Mansfield E, Pastan I, FitzGerald DJ. Characterization of RFB4-Pseudomonas exotoxin A immunotoxins targeted to CD22 on B-cell malignancies Bioconjugate Chemistry. 7: 557-563. PMID 8889017 DOI: 10.1021/bc960043y |
0.36 |
|
| 1996 |
Kobayashi K, Ohye T, Pastan I, Nagatsu T. A novel strategy for the negative selection in mouse embryonic stem cells operated with immunotoxin-mediated cell targeting. Nucleic Acids Research. 24: 3653-5. PMID 8836200 DOI: 10.1093/NAR/24.18.3653 |
0.359 |
|
| 1996 |
Baudard M, Flotte TR, Aran JM, Thierry AR, Pastan I, Pang MG, Kearns WG, Gottesman MM. Expression of the human multidrug resistance and glucocerebrosidase cDNAs from adeno-associated vectors: efficient promoter activity of AAV sequences and in vivo delivery via liposomes. Human Gene Therapy. 7: 1309-22. PMID 8818718 DOI: 10.1089/Hum.1996.7.11-1309 |
0.339 |
|
| 1996 |
Baldwin RL, Kobrin MS, Tran T, Pastan I, Korc M. Cytotoxic effects of TGF-α-Pseudomonas exotoxin A fusion protein in human pancreatic carcinoma cells Pancreas. 13: 16-21. PMID 8783329 DOI: 10.1097/00006676-199607000-00002 |
0.353 |
|
| 1996 |
Aksentijevich I, Pastan I, Lunardi-Iskandar Y, Gallo RC, Gottesman MM, Thierry AR. In vitro and in vivo liposome-mediated gene transfer leads to human MDR1 expression in mouse bone marrow progenitor cells. Human Gene Therapy. 7: 1111-22. PMID 8773513 DOI: 10.1089/Hum.1996.7.9-1111 |
0.316 |
|
| 1996 |
Prior TI, Kunwar S, Pastan I. Studies on the activity of barnase toxins in vitro and in vivo. Bioconjugate Chemistry. 7: 23-9. PMID 8741987 DOI: 10.1021/bc9500655 |
0.317 |
|
| 1996 |
Li M, Dyda F, Benhar I, Pastan I, Davies DR. Crystal structure of the catalytic domain of Pseudomonas exotoxin A complexed with a nicotinamide adenine dinucleotide analog: implications for the activation process and for ADP ribosylation. Proceedings of the National Academy of Sciences of the United States of America. 93: 6902-6. PMID 8692916 DOI: 10.1073/Pnas.93.14.6902 |
0.556 |
|
| 1996 |
Reiter Y, Wright AF, Tonge DW, Pastan I. Recombinant single-chain and disulfide-stabilized Fv-immunotoxins that cause complete regression of a human colon cancer xenograft in nude mice. International Journal of Cancer. 67: 113-23. PMID 8690511 DOI: 10.1002/(SICI)1097-0215(19960703)67:1<113::AID-IJC19>3.0.CO;2-F |
0.346 |
|
| 1996 |
Johnson SW, Shen DW, Pastan I, Gottesman MM, Hamilton TC. Cross-resistance, cisplatin accumulation, and platinum-DNA adduct formation and removal in cisplatin-sensitive and -resistant human hepatoma cell lines Experimental Cell Research. 226: 133-139. PMID 8660948 DOI: 10.1006/Excr.1996.0211 |
0.313 |
|
| 1996 |
Kuan CT, Pastan I. Improved antitumor activity of a recombinant anti-Lewisy immunotoxin not requiring proteolytic activation Proceedings of the National Academy of Sciences of the United States of America. 93: 974-978. PMID 8577771 DOI: 10.1073/PNAS.93.3.974 |
0.329 |
|
| 1996 |
Germann UA, Chambers TC, Ambudkar SV, Licht T, Cardarelli CO, Pastan I, Gottesman MM. Characterization of phosphorylation-defective mutants of human P-glycoprotein expressed in mammalian cells. The Journal of Biological Chemistry. 271: 1708-16. PMID 8576173 DOI: 10.1074/Jbc.271.3.1708 |
0.311 |
|
| 1996 |
Chang K, Pastan I. Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. Proceedings of the National Academy of Sciences of the United States of America. 93: 136-140. PMID 8552591 DOI: 10.1073/Pnas.93.1.136 |
0.356 |
|
| 1996 |
Fitzgerald D, Pastan I. Recombinant immunotoxins for the treatment of cancer Journal of Controlled Release. 39: 261-265. DOI: 10.1016/0168-3659(95)00200-6 |
0.347 |
|
| 1995 |
Kreitman RJ, Pastan I. Targeting Pseudomonas exotoxin to hematologic malignancies Seminars in Cancer Biology. 6: 297-306. PMID 8562907 DOI: 10.1006/SCBI.1995.0038 |
0.377 |
|
| 1995 |
Benhar I, Padlan EA, Jung SH, Lee B, Pastan I. Rapid humanization of the Fv of monoclonal antibody B3 by using framework exchange of the recombinant immunotoxin B3(Fv)-PE38. Proceedings of the National Academy of Sciences of the United States of America. 91: 12051-5. PMID 7991583 DOI: 10.1073/Pnas.91.25.12051 |
0.57 |
|
| 1995 |
Brinkmann U, Chowdhury PS, Roscoe DM, Pastan I. Phage display of disulfide-stabilized Fv fragments. Journal of Immunological Methods. 182: 41-50. PMID 7769243 DOI: 10.1016/0022-1759(95)00016-4 |
0.326 |
|
| 1995 |
Campain JA, Gottesman MM, Pastan I. A novel mutant topoisomerase II alpha present in VP-16-resistant human melanoma cell lines has a deletion of alanine 429. Biochemistry. 33: 11327-32. PMID 7727383 DOI: 10.1021/Bi00203A030 |
0.324 |
|
| 1995 |
Webber KO, Reiter Y, Brinkmann U, Kreitman R, Pastan I. Preparation and characterization of a disulfide-stabilized Fv fragment of the anti-Tac antibody: Comparison with its single-chain analog Molecular Immunology. 32: 249-258. PMID 7723770 DOI: 10.1016/0161-5890(94)00150-Y |
0.313 |
|
| 1995 |
Benhar I, Pastan I. Cloning, expression and characterization of the Fv fragments of the anti-carbohydrate mAbs B1 and B5 as single-chain immunotoxins. Protein Engineering. 7: 1509-15. PMID 7716163 DOI: 10.1093/Protein/7.12.1509 |
0.591 |
|
| 1995 |
Shen DW, Akiyama S, Schoenlein P, Pastan I, Gottesman MM. Characterisation of high-level cisplatin-resistant cell lines established from a human hepatoma cell line and human KB adenocarcinoma cells: cross-resistance and protein changes. British Journal of Cancer. 71: 676-83. PMID 7710928 DOI: 10.1038/Bjc.1995.134 |
0.364 |
|
| 1995 |
Reiter Y, Kurucz I, Brinkmann U, Jung SH, Lee B, Segal DM, Pastan I. Construction of a functional disulfide-stabilized TCR Fv indicates that antibody and TCR Fv frameworks are very similar in structure. Immunity. 2: 281-7. PMID 7697545 DOI: 10.1016/1074-7613(95)90052-7 |
0.303 |
|
| 1995 |
Evans GL, Ni B, Hrycyna CA, Chen D, Ambudkar SV, Pastan I, Germann UA, Gottesman MM. Heterologous expression systems for P-glycoprotein: E. coli, yeast, and baculovirus. Journal of Bioenergetics and Biomembranes. 27: 43-52. PMID 7629051 DOI: 10.1007/Bf02110330 |
0.306 |
|
| 1995 |
Benhar I, Reiter Y, Pai LH, Pastan I. Administration of disulfide-stabilized Fv-immunotoxins B1(dsFv)-PE38 and B3(dsFv)-PE38 by continuous infusion increases their efficacy in curing large tumor xenografts in nude mice. International Journal of Cancer. 62: 351-5. PMID 7628878 DOI: 10.1002/Ijc.2910620320 |
0.567 |
|
| 1995 |
Debinski W, Obiri NI, Pastan I, Puri RK. A novel chimeric protein composed of interleukin 13 and Pseudomonas exotoxin is highly cytotoxic to human carcinoma cells expressing receptors for interleukin 13 and interleukin 4 Journal of Biological Chemistry. 270: 16775-16780. PMID 7622490 DOI: 10.1074/jbc.270.28.16775 |
0.364 |
|
| 1995 |
Li M, Dyda F, Benhar I, Pastan I, Davies DR. The crystal structure of Pseudomonas aeruginosa exotoxin domain III with nicotinamide and AMP: conformational differences with the intact exotoxin. Proceedings of the National Academy of Sciences of the United States of America. 92: 9308-12. PMID 7568123 DOI: 10.1073/Pnas.92.20.9308 |
0.557 |
|
| 1995 |
Benhar I, Pastan I. Identification of residues that stabilize the single-chain Fv of monoclonal antibodies B3. The Journal of Biological Chemistry. 270: 23373-80. PMID 7559495 DOI: 10.1074/Jbc.270.40.23373 |
0.582 |
|
| 1995 |
Brinkmann U, Brinkmann E, Gallo M, Pastan I. Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1. Proceedings of the National Academy of Sciences of the United States of America. 92: 10427-31. PMID 7479798 DOI: 10.1073/PNAS.92.22.10427 |
0.339 |
|
| 1995 |
Licht T, Aksentijevich I, Gottesman M, Pastan I. Efficient expression of functional human MDR1 gene in murine bone marrow after retroviral transduction of purified hematopoietic stem cells Blood. 86: 111-121. DOI: 10.1182/blood.V86.1.111.bloodjournal861111 |
0.327 |
|
| 1995 |
Brinkmann U, Brinkmann E, Pastan I. Expression Cloning of cDNAs That Render Cancer Cells Resistant to Pseudomonas and Diphtheria Toxin and Immunotoxins Molecular Medicine. 1: 206-216. DOI: 10.1007/BF03401568 |
0.365 |
|
| 1995 |
Brinkmann U, Pastan I. Recombinant Immunotoxins: From Basic Research to Cancer Therapy Methods. 8: 143-156. DOI: 10.1006/METH.1995.9992 |
0.314 |
|
| 1994 |
Draoui M, Siegall CB, FitzGerald D, Pastan I, Moody TW. TGFα-PE40 inhibits non-small cell lung cancer growth Life Sciences. 54: 445-453. PMID 8309347 DOI: 10.1016/0024-3205(94)00403-X |
0.305 |
|
| 1994 |
Kreitman RJ, Pastan I. Purification and characterization of IL6-PE4E, a recombinant fusion of interleukin 6 with Pseudomonas exotoxin. Bioconjugate Chemistry. 4: 581-5. PMID 8305530 DOI: 10.1021/BC00024A025 |
0.302 |
|
| 1994 |
Fu YM, Mesri EA, Yu ZX, Kreitman RJ, Pastan I, Epstein SE. Cytotoxic effects of vascular smooth muscle cells of the chimeric toxin, heparin binding TGF alpha-Pseudomonas exotoxin. Cardiovascular Research. 27: 1691-7. PMID 8287449 DOI: 10.1093/cvr/27.9.1691 |
0.308 |
|
| 1994 |
Kreitman RJ, Chang CN, Hudson DV, Queen C, Bailon P, Pastan I. Anti-Tac(Fab)-PE40, a recombinant double-chain immunotoxin which kills interleukin-2-receptor-bearing cells and induces complete remission in an in vivo tumor model. International Journal of Cancer. 57: 856-64. PMID 8206679 DOI: 10.1002/IJC.2910570615 |
0.352 |
|
| 1994 |
Debinski W, Pastan I. An immunotoxin with increased activity and homogeneity produced by reducing the number of lysine residues in recombinant Pseudomonas exotoxin Bioconjugate Chemistry. 5: 40-46. PMID 8199233 DOI: 10.1021/Bc00025A006 |
0.312 |
|
| 1994 |
Chang K, Pastan I. Molecular cloning and expression of a cDNA encoding a protein detected by the K1 antibody from an ovarian carcinoma (OVCAR-3) cell line. International Journal of Cancer. 57: 90-7. PMID 8150545 DOI: 10.1002/IJC.2910570117 |
0.37 |
|
| 1994 |
Puri RK, Debinski W, Obiri N, Kreitman R, Pastan I. Human Renal Cell Carcinoma Cells Are Sensitive to the Cytotoxic Effect of a Chimeric Protein Composed of Human Interleukin-4 and Pseudomonas Exotoxin Cellular Immunology. 154: 369-379. PMID 8131209 DOI: 10.1006/cimm.1994.1084 |
0.341 |
|
| 1994 |
Debinski W, Puri RK, Pastan I. Interleukin-4 receptors expressed on tumor cells may serve as a target for anticancer therapy using chimeric Pseudomonas exotoxin International Journal of Cancer. 58: 744-748. PMID 8077061 DOI: 10.1002/Ijc.2910580520 |
0.312 |
|
| 1994 |
Reiter Y, Brinkmann U, Webber KO, Jung SH, Lee B, Pastan I. Engineering interchain disulfide bonds into conserved framework regions of Fv fragments: improved biochemical characteristics of recombinant immunotoxins containing disulfide-stabilized Fv. Protein Engineering. 7: 697-704. PMID 8073039 DOI: 10.1093/PROTEIN/7.5.697 |
0.307 |
|
| 1994 |
Jung SH, Pastan I, Lee B. Design of interchain disulfide bonds in the framework region of the Fv fragment of the monoclonal antibody B3. Proteins. 19: 35-47. PMID 8066084 DOI: 10.1002/PROT.340190106 |
0.32 |
|
| 1994 |
Kameyama S, Kawamata H, Pastan I, Oyasu R. Cytotoxic effect of a fusion protein from transforming growth factor a and Pseudomonas exotoxin on rat and human bladder carcinoma cells in vitro Journal of Cancer Research and Clinical Oncology. 120: 507-512. PMID 8045915 DOI: 10.1007/Bf01221026 |
0.326 |
|
| 1994 |
Reiter Y, Kreitman RJ, Brinkmann U, Pastan I. Cytotoxic and antitumor activity of a recombinant immunotoxin composed of disulfide-stabilized anti-Tac Fv fragment and truncated Pseudomonas exotoxin. International Journal of Cancer. 58: 142-9. PMID 8014011 DOI: 10.1002/IJC.2910580123 |
0.338 |
|
| 1994 |
Licht T, Pastan I, Gottesman M, Herrmann F. P-glycoprotein-mediated multidrug resistance in normal and neoplastic hematopoietic cells. Annals of Hematology. 69: 159-71. PMID 7948302 DOI: 10.1007/Bf02215949 |
0.311 |
|
| 1994 |
Benhar I, Brinkmann U, Webber KO, Pastan I. Mutations of two lysine residues in the CDR loops of a recombinant immunotoxin that reduce its sensitivity to chemical derivatization. Bioconjugate Chemistry. 5: 321-326. PMID 7948099 DOI: 10.1021/Bc00028A007 |
0.575 |
|
| 1994 |
Roscoe DM, Jung SH, Benhar I, Pai L, Lee BK, Pastan I. Primate antibody response to immunotoxin: serological and computer-aided analysis of epitopes on a truncated form of Pseudomonas exotoxin. Infection and Immunity. 62: 5055-65. PMID 7927788 DOI: 10.1128/Iai.62.11.5055-5065.1994 |
0.569 |
|
| 1994 |
Gottesman MM, Germann UA, Aksentijevich I, Sugimoto Y, Cardarelli CO, Pastan I. Gene transfer of drug resistance genes. Implications for cancer therapy. Annals of the New York Academy of Sciences. 716: 126-38; discussion 1. PMID 7912913 DOI: 10.1111/J.1749-6632.1994.Tb21708.X |
0.317 |
|
| 1994 |
Reiter Y, Brinkmann U, Kreitman RJ, Jung SH, Lee B, Pastan I. Stabilization of the Fv fragments in recombinant immunotoxins by disulfide bonds engineered into conserved framework regions. Biochemistry. 33: 5451-9. PMID 7910034 DOI: 10.1021/BI00184A014 |
0.3 |
|
| 1994 |
Aran JM, Gottesman MM, Pastan I. Drug-selected coexpression of human glucocerebrosidase and P-glycoprotein using a bicistronic vector. Proceedings of the National Academy of Sciences of the United States of America. 91: 3176-80. PMID 7909160 DOI: 10.1073/pnas.91.8.3176 |
0.337 |
|
| 1994 |
Siegsmund MJ, Cardarelli C, Aksentijevich I, Sugimoto Y, Pastan I, Gottesman MM. Ketoconazole effectively reverses multidrug resistance in highly resistant KB cells. The Journal of Urology. 151: 485-91. PMID 7904313 DOI: 10.1016/S0022-5347(17)34999-6 |
0.307 |
|
| 1994 |
Siegall CB, Gawlak SL, Chace DF, Merwin JR, Pastan I. In vivo activities of acidic fibroblast growth factor-Pseudomonas exotoxin fusion proteins. Bioconjugate Chemistry. 5: 77-83. PMID 7515280 DOI: 10.1021/bc00025a010 |
0.357 |
|
| 1994 |
Gawlak SL, Pastan I, Siegall CB. Basic fibroblast growth factor-Pseudomonas exotoxin chimeric proteins; comparison with acidic fibroblast growth factor-Pseudomonas exotoxin. Bioconjugate Chemistry. 4: 483-9. PMID 7508267 DOI: 10.1021/BC00024A010 |
0.354 |
|
| 1994 |
Kreitman R, Bailon P, Chaudhary V, FitzGerald D, Pastan I. Recombinant immunotoxins containing anti-Tac(Fv) and derivatives of Pseudomonas exotoxin produce complete regression in mice of an interleukin-2 receptor-expressing human carcinoma Blood. 83: 426-434. DOI: 10.1182/blood.v83.2.426.426 |
0.363 |
|
| 1993 |
Jhappan C, Stahle C, Wolff M, Merlino G, Pastan I. An epidermal growth factor receptor promoter construct selectively expresses in the thymus and spleen of transgenic mice. Cellular Immunology. 149: 99-106. PMID 8513514 DOI: 10.1006/CIMM.1993.1139 |
0.333 |
|
| 1993 |
Theuer CP, FitzGerald DJ, Pastan I. A recombinant form of Pseudomonas exotoxin A containing transforming growth factor alpha near its carboxyl terminus for the treatment of bladder cancer. The Journal of Urology. 149: 1626-32. PMID 8501821 DOI: 10.1016/S0022-5347(17)36464-9 |
0.314 |
|
| 1993 |
Spence C, Nachman M, Gately MK, Kreitman RJ, Pastan I, Bailon P. Affinity purification and characterization of anti-Tac(Fv)-C3-PE38KDEL: A highly potent cytotoxic agent specific to cells bearing IL-2 receptors Bioconjugate Chemistry. 4: 63-68. PMID 8431514 DOI: 10.1021/BC00019A009 |
0.338 |
|
| 1993 |
Brinkmann U, Gallo M, Brinkmann E, Kunwar S, Pastan I. A recombinant immunotoxin that is active on prostate cancer cells and that is composed of the Fv region of monoclonal antibody PR1 and a truncated form of Pseudomonas exotoxin. Proceedings of the National Academy of Sciences of the United States of America. 90: 547-51. PMID 8421689 DOI: 10.1073/PNAS.90.2.547 |
0.331 |
|
| 1993 |
Mickisch GH, Pai LH, Siegsmund M, Campain J, Gottesman MM, Pastan I. Pseudomonas exotoxin conjugated to monoclonal antibody MRK16 specifically kills multidrug resistant cells in cultured renal carcinomas and in MDR-transgenic mice. The Journal of Urology. 149: 174-8. PMID 8417204 DOI: 10.1016/S0022-5347(17)36033-0 |
0.336 |
|
| 1993 |
Theuer CP, Pastan I. Immunotoxins and recombinant toxins in the treatment of solid carcinomas. American Journal of Surgery. 166: 284-8. PMID 8368439 DOI: 10.1016/S0002-9610(05)80975-4 |
0.368 |
|
| 1993 |
Fitzgerald D, Pastan I. Pseudomonas exotoxin and recombinant immunotoxins derived from it. Annals of the New York Academy of Sciences. 685: 740-5. PMID 8363279 DOI: 10.1111/j.1749-6632.1993.tb35935.x |
0.377 |
|
| 1993 |
Campain JA, Padmanabhan R, Hwang J, Gottesman MM, Pastan I. Characterization of an unusual mutant of human melanoma cells resistant to anticancer drugs that inhibit topoisomerase II. Journal of Cellular Physiology. 155: 414-25. PMID 8097746 DOI: 10.1002/Jcp.1041550224 |
0.321 |
|
| 1993 |
Kreitman RJ, Batra JK, Seetharam S, Chaudhary VK, FitzGerald DJ, Pastan I. Single-chain immunotoxin fusions between anti-Tac and Pseudomonas exotoxin: relative importance of the two toxin disulfide bonds. Bioconjugate Chemistry. 4: 112-20. PMID 7873642 DOI: 10.1021/bc00020a002 |
0.301 |
|
| 1993 |
Kunwar S, Pai LH, Pastan I. Cytotoxicity and antitumor effects of growth factor-toxin fusion proteins on human glioblastoma multiforme cells. Journal of Neurosurgery. 79: 569-76. PMID 7692018 DOI: 10.3171/jns.1993.79.4.0569 |
0.355 |
|
| 1993 |
FitzGerald DJ, Pastan I. Pseudomonas exotoxin: recombinant conjugates as therapeutic agents. Biochemical Society Transactions. 20: 731-4. PMID 1487051 DOI: 10.1042/BST0200731 |
0.325 |
|
| 1992 |
Chang K, Pastan I, Willingham MC. Isolation and characterization of a monoclonal antibody, K1, reactive with ovarian cancers and normal mesothelium. International Journal of Cancer. 50: 373-81. PMID 1735605 DOI: 10.1002/IJC.2910500308 |
0.325 |
|
| 1992 |
Kreitman RJ, Siegall CB, Chaudhary VK, FitzGerald DJ, Pastan I. Properties of chimeric toxins with two recognition domains: interleukin 6 and transforming growth factor alpha at different locations in Pseudomonas exotoxin. Bioconjugate Chemistry. 3: 63-8. PMID 1616951 DOI: 10.1021/bc00013a010 |
0.317 |
|
| 1992 |
Schoenlein PV, Shen DW, Barrett JT, Pastan I, Gottesman MM. Double minute chromosomes carrying the human multidrug resistance 1 and 2 genes are generated from the dimerization of submicroscopic circular DNAs in colchicine-selected KB carcinoma cells. Molecular Biology of the Cell. 3: 507-20. PMID 1611154 DOI: 10.1091/Mbc.3.5.507 |
0.305 |
|
| 1992 |
Brinkmann U, Pai LH, FitzGerald DJ, Pastan I. Alteration of a protease-sensitive region of Pseudomonas exotoxin prolongs its survival in the circulation of mice. Proceedings of the National Academy of Sciences of the United States of America. 89: 3065-9. PMID 1557414 DOI: 10.1073/PNAS.89.7.3065 |
0.322 |
|
| 1992 |
Batra JK, Kasprzyk PG, Bird RE, Pastan I, King CR. Recombinant anti-erbB2 immunotoxins containing Pseudomonas exotoxin. Proceedings of the National Academy of Sciences of the United States of America. 89: 5867-71. PMID 1352878 DOI: 10.1073/Pnas.89.13.5867 |
0.364 |
|
| 1992 |
Sorrentino BP, Brandt SJ, Bodine D, Gottesman M, Pastan I, Cline A, Nienhuis AW. Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1 Science. 257: 99-103. PMID 1352414 DOI: 10.1126/Science.1352414 |
0.305 |
|
| 1992 |
Chin KV, Chauhan SS, Abraham I, Sampson KE, Krolczyk AJ, Wong M, Schimmer B, Pastan I, Gottesman MM. Reduced mRNA levels for the multidrug-resistance genes in cAMP-dependent protein kinase mutant cell lines. Journal of Cellular Physiology. 152: 87-94. PMID 1352302 DOI: 10.1002/Jcp.1041520112 |
0.35 |
|
| 1992 |
Buchner J, Pastan I, Brinkmann U. A method for increasing the yield of properly folded recombinant fusion proteins: single-chain immunotoxins from renaturation of bacterial inclusion bodies. Analytical Biochemistry. 205: 263-70. PMID 1332541 DOI: 10.1016/0003-2697(92)90433-8 |
0.322 |
|
| 1992 |
Biro S, Siegall CB, Fu YM, Speir E, Pastan I, Epstein SE. In vitro effects of a recombinant toxin targeted to the fibroblast growth factor receptor on rat vascular smooth muscle and endothelial cells. Circulation Research. 71: 640-5. PMID 1323436 DOI: 10.1161/01.RES.71.3.640 |
0.321 |
|
| 1992 |
Kreitman RJ, FitzGerald D, Pastan I. Targeting growth factor receptors with fusion toxins. International Journal of Immunopharmacology. 14: 465-72. PMID 1319965 DOI: 10.1016/0192-0561(92)90177-M |
0.369 |
|
| 1992 |
Kreitman R, Chaudhary V, Kozak R, FitzGerald D, Waldman T, Pastan I. Recombinant toxins containing the variable domains of the anti-Tac monoclonal antibody to the interleukin-2 receptor kill malignant cells from patients with chronic lymphocytic leukemia Blood. 80: 2344-2352. DOI: 10.1182/BLOOD.V80.9.2344.BLOODJOURNAL8092344 |
0.348 |
|
| 1992 |
Mickisch G, Aksentijevich I, Schoenlein P, Goldstein L, Galski H, Stahle C, Sachs D, Pastan I, Gottesman M. Transplantation of bone marrow cells from transgenic mice expressing the human MDR1 gene results in long-term protection against the myelosuppressive effect of chemotherapy in mice Blood. 79: 1087-1093. DOI: 10.1182/blood.v79.4.1087.bloodjournal7941087 |
0.31 |
|
| 1991 |
Siegall CB, FitzGerald DJ, Pastan I. Selective killing of IL6 receptor bearing myeloma cells using recombinant IL6-Pseudomonas toxin. Current Topics in Microbiology and Immunology. 166: 63-9. PMID 2127396 DOI: 10.1007/978-3-642-75889-8_9 |
0.36 |
|
| 1991 |
FitzGerald D, Idziorek T, Batra JK, Willingham M, Pastan I. Antitumor activity of a thioether-linked immunotoxin: OVB3-PE. Bioconjugate Chemistry. 1: 264-8. PMID 2096919 DOI: 10.1021/BC00004A006 |
0.312 |
|
| 1991 |
Pai LH, Batra JK, FitzGerald DJ, Willingham MC, Pastan I. Anti-tumor activities of immunotoxins made of monoclonal antibody B3 and various forms of Pseudomonas exotoxin. Proceedings of the National Academy of Sciences of the United States of America. 88: 3358-62. PMID 2014255 DOI: 10.1073/PNAS.88.8.3358 |
0.337 |
|
| 1991 |
Batra JK, Fitzgerald DJ, Chaudhary VK, Pastan I. Single-chain immunotoxins directed at the human transferrin receptor containing Pseudomonas exotoxin A or diphtheria toxin: anti-TFR(Fv)-PE40 and DT388-anti-TFR(Fv). Molecular and Cellular Biology. 11: 2200-5. PMID 2005905 DOI: 10.1128/mcb.11.4.2200 |
0.356 |
|
| 1991 |
Chaudhary VK, FitzGerald DJ, Pastan I. A proper amino terminus of diphtheria toxin is important for cytotoxicity. Biochemical and Biophysical Research Communications. 180: 545-51. PMID 1953725 DOI: 10.1016/s0006-291x(05)81099-x |
0.306 |
|
| 1991 |
Siegall CB, Ogata M, Pastan I, FitzGerald DJ. Analysis of sequences in domain II of Pseudomonas exotoxin A which mediate translocation. Biochemistry. 30: 7154-9. PMID 1906738 DOI: 10.1021/BI00243A016 |
0.316 |
|
| 1991 |
Prior TI, FitzGerald DJ, Pastan I. Barnase toxin: A new chimeric toxin composed of pseudomonas exotoxin A and barnase Cell. 64: 1017-1023. PMID 1900455 DOI: 10.1016/0092-8674(91)90325-S |
0.358 |
|
| 1991 |
Epstein SE, Siegall CB, Biro S, Fu YM, FitzGerald D, Pastan I. Cytotoxic effects of a recombinant chimeric toxin on rapidly proliferating vascular smooth muscle cells. Circulation. 84: 778-87. PMID 1860221 DOI: 10.1161/01.CIR.84.2.778 |
0.366 |
|
| 1991 |
Siegall CB, Epstein S, Speir E, Hla T, Forough R, Maciag T, Fitzgerald DJ, Pastan I. Cytotoxic activity of chimeric proteins composed of acidic fibroblast growth factor and Pseudomonas exotoxin on a variety of cell types. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 5: 2843-9. PMID 1717336 DOI: 10.1096/Fasebj.5.13.1717336 |
0.303 |
|
| 1991 |
Ogata M, Pastan I, FitzGerald D. Analysis of Pseudomonas exotoxin activation and conformational changes by using monoclonal antibodies as probes. Infection and Immunity. 59: 407-14. PMID 1702764 DOI: 10.1128/IAI.59.1.407-414.1991 |
0.318 |
|
| 1991 |
Pastan I, FitzGerald D. Recombinant toxins for cancer treatment. Science (New York, N.Y.). 254: 1173-7. PMID 1683495 DOI: 10.1126/SCIENCE.1683495 |
0.362 |
|
| 1991 |
Mickisch GH, Merlino GT, Aiken PM, Gottesman MM, Pastan I. New potent verapamil derivatives that reverse multidrug resistance in human renal carcinoma cells and in transgenic mice expressing the human MDR1 gene. The Journal of Urology. 146: 447-53. PMID 1677434 DOI: 10.1016/S0022-5347(17)37822-9 |
0.313 |
|
| 1991 |
Padmanabhan R, Tsuruo T, Kane SE, Willingham MC, Howard BH, Gottesman MM, Pastan I. Magnetic-affinity cell sorting of human multidrug-resistant cells. Journal of the National Cancer Institute. 83: 565-9. PMID 1672384 DOI: 10.1093/Jnci/83.8.565 |
0.337 |
|
| 1991 |
Heimbrook DC, Stirdivant SM, Ahern JD, Balishin NL, Patrick DR, Edwards GM, Defeo-Jones D, FitzGerald DJ, Pastan I, Oliff A. Biological activity of a transforming growth factor-alpha--Pseudomonas exotoxin fusion protein in vitro and in vivo. Journal of Industrial Microbiology. 7: 203-7. PMID 1367127 DOI: 10.1007/BF01575884 |
0.317 |
|
| 1990 |
Kane SE, Reinhard DH, Fordis CM, Pastan I, Gottesman MM. A new vector using the human multidrug resistance gene as a selectable marker enables overexpression of foreign genes in eukaryotic cells. Gene. 84: 439-46. PMID 2575560 DOI: 10.1016/0378-1119(89)90518-0 |
0.362 |
|
| 1990 |
Kageyama R, Pastan I. Molecular cloning and characterization of a human DNA binding factor that represses transcription. Cell. 59: 815-25. PMID 2556218 DOI: 10.1016/0092-8674(89)90605-3 |
0.322 |
|
| 1990 |
Ueda K, Yamano Y, Kioka N, Kakehi Y, Yoshida O, Gottesman MM, Pastan I, Komano T. Detection of multidrug resistance (MDR1) gene RNA expression in human tumors by a sensitive ribonuclease protection assay. Japanese Journal of Cancer Research : Gann. 80: 1127-32. PMID 2481665 DOI: 10.1111/j.1349-7006.1989.tb02269.x |
0.337 |
|
| 1990 |
Batra JK, Chaudhary VK, FitzGerald D, Pastan I. TGF alpha-anti-Tac(Fv)-PE40: a bifunctional toxin cytotoxic for cells with EGF or IL2 receptors. Biochemical and Biophysical Research Communications. 171: 1-6. PMID 2393383 DOI: 10.1016/0006-291x(90)91347-u |
0.337 |
|
| 1990 |
Chaudhary VK, Gallo MG, FitzGerald DJ, Pastan I. A recombinant single-chain immunotoxin composed of anti-Tac variable regions and a truncated diphtheria toxin. Proceedings of the National Academy of Sciences of the United States of America. 87: 9491-4. PMID 2251289 DOI: 10.1073/pnas.87.23.9491 |
0.346 |
|
| 1990 |
Kreitman RJ, Chaudhary VK, Waldmann T, Willingham MC, FitzGerald DJ, Pastan I. The recombinant immunotoxin anti-Tac(Fv)-Pseudomonas exotoxin 40 is cytotoxic toward peripheral blood malignant cells from patients with adult T-cell leukemia. Proceedings of the National Academy of Sciences of the United States of America. 87: 8291-5. PMID 2236041 DOI: 10.1073/Pnas.87.21.8291 |
0.361 |
|
| 1990 |
Chaudhary VK, Batra JK, Gallo MG, Willingham MC, FitzGerald DJ, Pastan I. A rapid method of cloning functional variable-region antibody genes in Escherichia coli as single-chain immunotoxins. Proceedings of the National Academy of Sciences of the United States of America. 87: 1066-70. PMID 2105495 DOI: 10.1073/pnas.87.3.1066 |
0.328 |
|
| 1990 |
Chaudhary VK, Jinno Y, FitzGerald D, Pastan I. Pseudomonas exotoxin contains a specific sequence at the carboxyl terminus that is required for cytotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 87: 308-12. PMID 2104981 DOI: 10.1073/pnas.87.1.308 |
0.301 |
|
| 1990 |
Kane SE, Pastan I, Gottesman MM. Genetic basis of multidrug resistance of tumor cells. Journal of Bioenergetics and Biomembranes. 22: 593-618. PMID 1977744 DOI: 10.1007/Bf00762963 |
0.315 |
|
| 1990 |
Sugawara I, Koji T, Ueda K, Pastan I, Gottesman MM, Nakane PK, Mori S. In situ localization of the human multidrug-resistance gene mRNA using thymine-thymine dimerized single-stranded cDNA. Japanese Journal of Cancer Research : Gann. 81: 949-55. PMID 1977730 DOI: 10.1111/j.1349-7006.1990.tb02672.x |
0.319 |
|
| 1990 |
Germann UA, Willingham MC, Pastan I, Gottesman MM. Expression of the human multidrug transporter in insect cells by a recombinant baculovirus. Biochemistry. 29: 2295-303. PMID 1970935 DOI: 10.1021/Bi00461A013 |
0.326 |
|
| 1990 |
Germann UA, Chin KV, Pastan I, Gottesman MM. Retroviral transfer of a chimeric multidrug resistance-adenosine deaminase gene. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 4: 1501-7. PMID 1968408 DOI: 10.1096/fasebj.4.5.1968408 |
0.352 |
|
| 1990 |
Tanaka S, Currier SJ, Bruggemann EP, Ueda K, Germann UA, Pastan I, Gottesman MM. Use of recombinant P-glycoprotein fragments to produce antibodies to the multidrug transporter. Biochemical and Biophysical Research Communications. 166: 180-6. PMID 1967936 DOI: 10.1016/0006-291X(90)91928-L |
0.33 |
|
| 1989 |
Gottesman MM, Pastan I. Resistance to multiple chemotherapeutic agents in human cancer cells. Trends in Pharmacological Sciences. 9: 54-8. PMID 3072730 DOI: 10.1016/0165-6147(88)90117-4 |
0.338 |
|
| 1989 |
Richert ND, Aldwin L, Nitecki D, Gottesman MM, Pastan I. Stability and covalent modification of P-glycoprotein in multidrug-resistant KB cells. Biochemistry. 27: 7607-13. PMID 2905169 DOI: 10.1021/Bi00420A006 |
0.314 |
|
| 1989 |
Lai SL, Goldstein LJ, Gottesman MM, Pastan I, Tsai CM, Johnson BE, Mulshine JL, Ihde DC, Kayser K, Gazdar AF. MDR1 gene expression in lung cancer. Journal of the National Cancer Institute. 81: 1144-50. PMID 2746668 DOI: 10.1093/Jnci/81.15.1144 |
0.302 |
|
| 1989 |
Kanamaru H, Kakehi Y, Yoshida O, Nakanishi S, Pastan I, Gottesman MM. MDR1 RNA levels in human renal cell carcinomas: Correlation with grade and prediction of reversal of doxorubicin resistance by quinidine in tumor explants Journal of the National Cancer Institute. 81: 844-849. PMID 2724349 DOI: 10.1093/Jnci/81.11.844 |
0.511 |
|
| 1989 |
Kioka N, Tsubota J, Kakehi Y, Komano T, Gottesman MM, Pastan I, Ueda K. P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance. Biochemical and Biophysical Research Communications. 162: 224-31. PMID 2568832 DOI: 10.1016/0006-291X(89)91985-2 |
0.317 |
|
| 1989 |
Konen PL, Currier SJ, Rutherford AV, Gottesman MM, Pastan I, Willingham MC. The multidrug transporter: rapid modulation of efflux activity monitored in single cells by the morphologic effects of vinblastine and daunomycin. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 37: 1141-5. PMID 2567301 DOI: 10.1177/37.7.2567301 |
0.327 |
|
| 1989 |
Velu TJ, Beguinot L, Vass WC, Zhang K, Pastan I, Lowy DR. Retroviruses expressing different levels of the normal epidermal growth factor receptor: biological properties and new bioassay. Journal of Cellular Biochemistry. 39: 153-66. PMID 2565908 DOI: 10.1002/JCB.240390207 |
0.327 |
|
| 1989 |
Siegall CB, Xu YH, Chaudhary VK, Adhya S, Fitzgerald D, Pastan I. Cytotoxic activities of a fusion protein comprised of TGF alpha and Pseudomonas exotoxin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 3: 2647-52. PMID 2556314 DOI: 10.1096/Fasebj.3.14.2556314 |
0.327 |
|
| 1989 |
FitzGerald D, Pastan I. Targeted toxin therapy for the treatment of cancer. Journal of the National Cancer Institute. 81: 1455-63. PMID 2550658 DOI: 10.1093/JNCI/81.19.1455 |
0.383 |
|
| 1989 |
Batra JK, Jinno Y, Chaudhary VK, Kondo T, Willingham MC, FitzGerald DJ, Pastan I. Antitumor activity in mice of an immunotoxin made with anti-transferrin receptor and a recombinant form of Pseudomonas exotoxin. Proceedings of the National Academy of Sciences of the United States of America. 86: 8545-9. PMID 2510169 DOI: 10.1073/pnas.86.21.8545 |
0.357 |
|
| 1989 |
Chaudhary VK, Queen C, Junghans RP, Waldmann TA, FitzGerald DJ, Pastan I. A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin. Nature. 339: 394-7. PMID 2498664 DOI: 10.1038/339394A0 |
0.342 |
|
| 1989 |
Banker DE, Pastan I, Gottesman MM, Herschman HR. An epidermal growth factor-ricin A chain (EGF-RTA)-resistant mutant and an epidermal growth factor-Pseudomonas endotoxin (EGF-PE)-resistant mutant have distinct phenotypes. Journal of Cellular Physiology. 139: 51-7. PMID 2496133 DOI: 10.1002/Jcp.1041390109 |
0.338 |
|
| 1988 |
Velu TJ, Beguinot L, Vass WC, Willingham MC, Merlino GT, Pastan I, Lowy DR. Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogene. Science (New York, N.Y.). 238: 1408-10. PMID 3500513 DOI: 10.1126/SCIENCE.3500513 |
0.329 |
|
| 1988 |
Kageyama R, Merlino GT, Pastan I. A transcription factor active on the epidermal growth factor receptor gene. Proceedings of the National Academy of Sciences of the United States of America. 85: 5016-20. PMID 3393529 DOI: 10.1073/PNAS.85.14.5016 |
0.3 |
|
| 1988 |
Kakehi Y, Kanamaru H, Yoshida O, Ohkubo H, Nakanishi S, Gottesman MM, Pastan I. Measurement of multidrug-resistance messenger RNA in urogenital cancers; elevated expression in renal cell carcinoma is associated with intrinsic drug resistance Journal of Urology. 139: 862-865. PMID 3352061 DOI: 10.1016/S0022-5347(17)42663-2 |
0.438 |
|
| 1988 |
Amano F, Pastan I, Gottesman MM. Genetic characterization of human KB cell lines resistant to epidermal growth factor: Pseudomonas exotoxin conjugates. Journal of Cellular Physiology. 135: 527-32. PMID 3260900 DOI: 10.1002/jcp.1041350323 |
0.333 |
|
| 1988 |
Pastan I, Gottesman MM, Ueda K, Lovelace E, Rutherford AV, Willingham MC. A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells. Proceedings of the National Academy of Sciences of the United States of America. 85: 4486-90. PMID 2898143 DOI: 10.1073/Pnas.85.12.4486 |
0.323 |
|
| 1988 |
Kane SE, Troen BR, Gal S, Ueda K, Pastan I, Gottesman MM. Use of cloned multidrug resistance gene for coamplification and overproduction of major excreted protein,a transformation-regulated secreted acid protease Molecular and Cellular Biology. 8: 3316-3321. PMID 2463474 DOI: 10.1128/Mcb.8.8.3316 |
0.357 |
|
| 1987 |
Fojo AT, Shen DW, Mickley LA, Pastan I, Gottesman MM. Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug-resistance gene. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 5: 1922-7. PMID 3681376 DOI: 10.1200/Jco.1987.5.12.1922 |
0.307 |
|
| 1987 |
Hasumura S, Kitagawa S, Lovelace E, Willingham MC, Pastan I, Cheng S. Characterization of a membrane-associated 3,3',5-triiodo-L-thyronine binding protein by use of monoclonal antibodies. Biochemistry. 25: 7881-8. PMID 3542039 DOI: 10.1021/bi00372a014 |
0.337 |
|
| 1987 |
FitzGerald DJ, Willingham MC, Cardarelli CO, Hamada H, Tsuruo T, Gottesman MM, Pastan I. A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells. Proceedings of the National Academy of Sciences of the United States of America. 84: 4288-92. PMID 3495806 DOI: 10.1073/Pnas.84.12.4288 |
0.33 |
|
| 1987 |
Ueda K, Cardarelli C, Gottesman MM, Pastan I. Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine. Proceedings of the National Academy of Sciences of the United States of America. 84: 3004-8. PMID 3472246 DOI: 10.1073/Pnas.84.9.3004 |
0.327 |
|
| 1987 |
Chaudhary VK, FitzGerald DJ, Adhya S, Pastan I. Activity of a recombinant fusion protein between transforming growth factor type alpha and Pseudomonas toxin. Proceedings of the National Academy of Sciences of the United States of America. 84: 4538-42. PMID 3299371 DOI: 10.1073/Pnas.84.13.4538 |
0.334 |
|
| 1987 |
Cornwell MM, Tsuruo T, Gottesman MM, Pastan I. ATP-binding properties of P glycoprotein from multidrug-resistant KB cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 1: 51-4. PMID 2886389 DOI: 10.1096/Fasebj.1.1.2886389 |
0.319 |
|
| 1987 |
Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I, Willingham MC. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proceedings of the National Academy of Sciences of the United States of America. 84: 7735-8. PMID 2444983 DOI: 10.1073/pnas.84.21.7735 |
0.326 |
|
| 1987 |
Hwang J, Richert N, Pastan I, Gottesman MM. Mutant KB cells with decreased EGF receptor expression: biochemical characterization. Journal of Cellular Physiology. 133: 127-34. PMID 2444605 DOI: 10.1002/jcp.1041330116 |
0.324 |
|
| 1986 |
Shen DW, Fojo A, Roninson IB, Chin JE, Soffir R, Pastan I, Gottesman MM. Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene. Molecular and Cellular Biology. 6: 4039-45. PMID 3796599 DOI: 10.1128/Mcb.6.11.4039 |
0.326 |
|
| 1986 |
Roninson IB, Chin JE, Choi KG, Gros P, Housman DE, Fojo A, Shen DW, Gottesman MM, Pastan I. Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells. Proceedings of the National Academy of Sciences of the United States of America. 83: 4538-42. PMID 3459187 DOI: 10.1073/Pnas.83.12.4538 |
0.319 |
|
| 1986 |
Cornwell MM, Safa AR, Felsted RL, Gottesman MM, Pastan I. Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling. Proceedings of the National Academy of Sciences of the United States of America. 83: 3847-50. PMID 3459160 DOI: 10.1073/Pnas.83.11.3847 |
0.343 |
|
| 1986 |
Cheng SY, Hasumura S, Willingham MC, Pastan I. Purification and characterization of a membrane-associated 3,3',5-triiodo-L-thyronine binding protein from a human carcinoma cell line. Proceedings of the National Academy of Sciences of the United States of America. 83: 947-51. PMID 3006034 DOI: 10.1073/pnas.83.4.947 |
0.319 |
|
| 1986 |
King CR, Kraus MH, Williams LT, Merlino GT, Pastan IH, Aaronson SA. Human tumor cell lines with EGF receptor gene amplification in the absence of aberrant sized mRNAs. Nucleic Acids Research. 13: 8477-86. PMID 3001641 DOI: 10.1093/Nar/13.23.8477 |
0.56 |
|
| 1986 |
Pastan I, Hanover J, Willingham M. The cellular entry of EGF and transferrin: a problem in intracellular sorting. Current Topics in Cellular Regulation. 26: 17-25. PMID 3000694 DOI: 10.1016/B978-0-12-152826-3.50009-7 |
0.486 |
|
| 1986 |
Ueda K, Cornwell MM, Gottesman MM, Pastan I, Roninson IB, Ling V, Riordan JR. The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein. Biochemical and Biophysical Research Communications. 141: 956-62. PMID 2880583 DOI: 10.1016/S0006-291X(86)80136-X |
0.308 |
|
| 1986 |
Chen Cj, Chin JE, Ueda K, Clark DP, Pastan I, Gottesman MM, Roninson IB. Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells Cell. 47: 381-389. PMID 2876781 DOI: 10.1016/0092-8674(86)90595-7 |
0.318 |
|
| 1986 |
Hanover JA, D'Souza P, August T, Pastan I, Willingham MC. Monoclonal antibodies against a glycoprotein localized in coated pits and endocytic vesicles inhibit α2-macroglobulin binding and uptake Journal of Biological Chemistry. 261: 16732-16737. PMID 2430970 |
0.518 |
|
| 1985 |
Willingham MC, Pastan I. Endocytosis and exocytosis: current concepts of vesicle traffic in animal cells. International Review of Cytology. 92: 51-92. PMID 6150907 DOI: 10.1016/S0074-7696(08)61324-8 |
0.308 |
|
| 1985 |
Gottesman MM, Roth C, Vlahakis G, Pastan I. Cholera toxin treatment stimulates tumorigenicity of Rous sarcoma virus-transformed cells. Molecular and Cellular Biology. 4: 2639-42. PMID 6098816 DOI: 10.1128/Mcb.4.12.2639 |
0.32 |
|
| 1985 |
Xu YH, Richert N, Ito S, Merlino GT, Pastan I. Characterization of epidermal growth factor receptor gene expression in malignant and normal human cell lines. Proceedings of the National Academy of Sciences of the United States of America. 81: 7308-12. PMID 6095284 DOI: 10.1073/PNAS.81.23.7308 |
0.343 |
|
| 1985 |
Hanover JA, Pastan I, Willingham MC. Inhibition of phosphatidylcholine synthesis does not alter uptake of transferrin by LM fibroblasts Experimental Cell Research. 157: 276-281. PMID 3972013 DOI: 10.1016/0014-4827(85)90170-3 |
0.545 |
|
| 1985 |
Pirker R, FitzGerald DJP, Hamilton TC, Ozols RF, Laird W, Frankel AE, Willingham MC, Pastan I. Characterization of immunotoxins active against ovarian cancer cell lines Journal of Clinical Investigation. 76: 1261-1267. PMID 3930572 DOI: 10.1172/Jci112082 |
0.348 |
|
| 1985 |
Fojo AT, Whang-Peng J, Gottesman MM, Pastan I. Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells. Proceedings of the National Academy of Sciences of the United States of America. 82: 7661-5. PMID 3865187 DOI: 10.1073/Pnas.82.22.7661 |
0.304 |
|
| 1985 |
Richert N, Akiyama S, Shen D, Gottesman MM, Pastan I. Multiply drug-resistant human KB carcinoma cells have decreased amounts of a 75-kDa and a 72-kDa glycoprotein. Proceedings of the National Academy of Sciences of the United States of America. 82: 2330-3. PMID 3857583 DOI: 10.1073/Pnas.82.8.2330 |
0.324 |
|
| 1985 |
Akiyama Si, Fojo A, Hanover JA, Pastan I, Gottesman MM. Isolation and genetic characterization of human KB cell lines resistant to multiple drugs Somatic Cell and Molecular Genetics. 11: 117-126. PMID 3856953 DOI: 10.1007/BF01534700 |
0.518 |
|
| 1985 |
Hunts JH, Shimizu N, Yamamoto T, Toyoshima K, Merlino GT, Xu YH, Pastan I. Translocation chromosome 7 of A431 cells contains amplification and rearrangement of EGF receptor gene responsible for production of variant mRNA. Somatic Cell and Molecular Genetics. 11: 477-84. PMID 2994239 DOI: 10.1007/Bf01534841 |
0.316 |
|
| 1985 |
Ishii S, Xu YH, Stratton RH, Roe BA, Merlino GT, Pastan I. Characterization and sequence of the promoter region of the human epidermal growth factor receptor gene. Proceedings of the National Academy of Sciences of the United States of America. 82: 4920-4. PMID 2991899 DOI: 10.1073/pnas.82.15.4920 |
0.306 |
|
| 1985 |
Merlino GT, Xu Y, Richert N, Clark AJL, Ishii S, Banks-Schlegel S, Pastan I. Elevated epidermal growth factor receptor gene copy number and expression in a squamous carcinoma cell line. Journal of Clinical Investigation. 75: 1077-1079. PMID 2984254 DOI: 10.1172/Jci111770 |
0.332 |
|
| 1985 |
Lyall RM, Pastan I, Willingham MC. EGF induces receptor down-regulation with no receptor recycling in KB cells. Journal of Cellular Physiology. 122: 166-70. PMID 2981235 DOI: 10.1002/JCP.1041220125 |
0.307 |
|
| 1985 |
Hanover JA, Beguinot L, Willingham MC, Pastan IH. Transit of receptors for epidermal growth factor and transferrin through clathrin-coated pits. Analysis of the kinetics of receptor entry Journal of Biological Chemistry. 260: 15938-15945. PMID 2866188 |
0.477 |
|
| 1985 |
Beguinot L, Hanover JA, Ito S, Richert ND, Willingham MC, Pastan I. Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors Proceedings of the National Academy of Sciences of the United States of America. 82: 2774-2778. PMID 2859591 DOI: 10.1073/Pnas.82.9.2774 |
0.55 |
|
| 1985 |
Dickson RB, Hanover JA, Pastan I, Willingham MC. Isolation of receptosomes (endosomes) from human KB cells Methods in Enzymology. 257-271. PMID 2859514 DOI: 10.1016/0076-6879(85)09091-7 |
0.564 |
|
| 1985 |
Chen JW, Murphy TL, Willingham MC, Pastan I, August JT. Identification of two lysosomal membrane glycoproteins. The Journal of Cell Biology. 101: 85-95. PMID 2409098 DOI: 10.1083/JCB.101.1.85 |
0.322 |
|
| 1984 |
Seth P, Fitzgerald D, Ginsberg H, Willingham M, Pastan I. Evidence that the penton base of adenovirus is involved in potentiation of toxicity of Pseudomonas exotoxin conjugated to epidermal growth factor. Molecular and Cellular Biology. 4: 1528-33. PMID 6333584 DOI: 10.1128/MCB.4.8.1528 |
0.312 |
|
| 1984 |
Seth P, Fitzgerald DJ, Willingham MC, Pastan I. Role of a low-pH environment in adenovirus enhancement of the toxicity of a Pseudomonas exotoxin-epidermal growth factor conjugate. Journal of Virology. 51: 650-5. PMID 6332200 DOI: 10.1128/JVI.51.3.650-655.1984 |
0.316 |
|
| 1984 |
Xu YH, Ishii S, Clark AJ, Sullivan M, Wilson RK, Ma DP, Roe BA, Merlino GT, Pastan I. Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells. Nature. 309: 806-10. PMID 6330563 DOI: 10.1038/309806a0 |
0.325 |
|
| 1984 |
McKeon C, Pastan I, de Crombrugghe B. DNase I sensitivity of the alpha 2(I) collagen gene: correlation with its expression but not with its methylation pattern. Nucleic Acids Research. 12: 3491-502. PMID 6328424 DOI: 10.1093/nar/12.8.3491 |
0.548 |
|
| 1984 |
Beguinot L, Lyall RM, Willingham MC, Pastan I. Down-regulation of the epidermal growth factor receptor in KB cells is due to receptor internalization and subsequent degradation in lysosomes. Proceedings of the National Academy of Sciences of the United States of America. 81: 2384-8. PMID 6326124 DOI: 10.1073/PNAS.81.8.2384 |
0.313 |
|
| 1984 |
Willingham MC, Pastan I. Endocytosis and membrane traffic in cultured cells. Recent Progress in Hormone Research. 40: 569-87. PMID 6207568 DOI: 10.1016/B978-0-12-571140-1.50018-9 |
0.328 |
|
| 1984 |
Merlino GT, Xu YH, Ishii S, Clark AJ, Semba K, Toyoshima K, Yamamoto T, Pastan I. Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells. Science (New York, N.Y.). 224: 417-9. PMID 6200934 DOI: 10.1126/Science.6200934 |
0.309 |
|
| 1984 |
Hanover JA, Willingham MC, Pastan I. Kinetics of transit of transferrin and epidermal growth factor through clathrin-coated membranes Cell. 39: 283-293. PMID 6149810 DOI: 10.1016/0092-8674(84)90006-0 |
0.531 |
|
| 1984 |
Willingham MC, Strader CD, Lefkowitz RJ, Pastan I. Morphologic demonstration of clathrin-coated pits in frog and turkey erythrocytes. Experimental Cell Research. 151: 573-7. PMID 6142826 DOI: 10.1016/0014-4827(84)90406-3 |
0.454 |
|
| 1984 |
Willingham MC, Hanover JA, Dickson RB, Pastan I. Morphologic characterization of the pathway of transferrin endocytosis and recycling in human KB cells Proceedings of the National Academy of Sciences of the United States of America. 81: 175-179. PMID 6141558 DOI: 10.1073/pnas.81.1.175 |
0.571 |
|
| 1984 |
Hasumura S, Rossi B, Alderson R, Pastan I, Cheng S. Antibodies against the plasma membrane 3,3',5-triiodo-L-thyronine binding protein of rat pituitary GH3 cells: partial characterization and cross-species immunoreactivity. Biochemical and Biophysical Research Communications. 124: 956-62. PMID 6095830 DOI: 10.1016/0006-291X(84)91051-9 |
0.316 |
|
| 1984 |
Akiyama T, Yamada Y, Ogawara H, Richert N, Pastan I, Yamamoto T, Kasuga M. Site-specific antibodies to the erbB oncogene product immunoprecipitate epidermal growth factor receptor. Biochemical and Biophysical Research Communications. 123: 797-802. PMID 6091642 DOI: 10.1016/0006-291X(84)90300-0 |
0.316 |
|
| 1984 |
Akiyama S, Gottesman MM, Hanover JA, Fitzgerald DJ, Willingham MC, Pastan I. Verapamil enhances the toxicity of conjugates of epidermal growth factor with Pseudomonas exotoxin and antitransferrin receptor with Pseudomonas exotoxin Journal of Cellular Physiology. 120: 271-279. PMID 6086678 DOI: 10.1002/jcp.1041200303 |
0.572 |
|
| 1983 |
Hanover JA, Rudick JE, Willingham MC, Pastan I. α2-macroglobulin binding to cultured fibroblasts: Identification by affinity chromatography of high-affinity binding sites Archives of Biochemistry and Biophysics. 227: 570-579. PMID 6667030 DOI: 10.1016/0003-9861(83)90486-1 |
0.535 |
|
| 1983 |
Mato JM, Pencev D, Vasanthakumar G, Schiffmann E, Pastan I. Inhibitors of endocytosis perturb phospholipid metabolism in rabbit neutrophils and other cells. Proceedings of the National Academy of Sciences of the United States of America. 80: 1929-32. PMID 6572951 DOI: 10.1073/PNAS.80.7.1929 |
0.306 |
|
| 1983 |
Hirano H, Yamada Y, Sullivan M, de Crombrugghe B, Pastan I, Yamada KM. Isolation of genomic DNA clones spanning the entire fibronectin gene. Proceedings of the National Academy of Sciences of the United States of America. 80: 46-50. PMID 6572007 DOI: 10.1073/pnas.80.1.46 |
0.628 |
|
| 1983 |
Dickson RB, Hanover JA, Willingham MC, Pastan I. Prelysosomal divergence of transferrin and epidermal growth factor during receptor-mediated endocytosis Biochemistry. 22: 5667-5674. PMID 6317024 DOI: 10.1021/Bi00293A033 |
0.54 |
|
| 1983 |
Dickson RB, Beguinot L, Hanover JA, Richert ND, Willingham MC, Pastan I. Isolation and characterization of a highly enriched preparation of receptosomes (endosomes) from a human cell line Proceedings of the National Academy of Sciences of the United States of America. 80: 5335-5339. PMID 6310570 DOI: 10.1073/Pnas.80.17.5335 |
0.563 |
|
| 1983 |
FitzGerald DJ, Trowbridge IS, Pastan I, Willingham MC. Enhancement of toxicity of antitransferrin receptor antibody-Pseudomonas exotoxin conjugates by adenovirus. Proceedings of the National Academy of Sciences of the United States of America. 80: 4134-8. PMID 6306663 DOI: 10.1073/Pnas.80.13.4134 |
0.326 |
|
| 1983 |
Hanover JA, Willingham MC, Pastan I. Receptor-mediated endocytosis of α2-macroglobulin: Solubilization and partial purification of the fibroblast α2-macroglobulin receptor Annals of the New York Academy of Sciences. 410-423. PMID 6202215 DOI: 10.1111/J.1749-6632.1983.Tb18135.X |
0.55 |
|
| 1983 |
Merlino GT, McKeon C, de Crombrugghe B, Pastan I. Regulation of the expression of genes encoding types I, II, and III collagen during chick embryonic development. The Journal of Biological Chemistry. 258: 10041-8. PMID 6193105 |
0.499 |
|
| 1983 |
Hanover JA, Cheng S, Willingham MC, Pastan IH. α2-Macroglobulin binding to cultured fibroblasts. Solubilization and partial purification of binding sites Journal of Biological Chemistry. 258: 370-377. PMID 6184373 |
0.489 |
|
| 1983 |
FitzGerald DJ, Padmanabhan R, Pastan I, Willingham MC. Adenovirus-induced release of epidermal growth factor and pseudomonas toxin into the cytosol of KB cells during receptor-mediated endocytosis. Cell. 32: 607-17. PMID 6130853 DOI: 10.1016/0092-8674(83)90480-4 |
0.309 |
|
| 1983 |
Pastan I, Willingham MC. Receptor-mediated endocytosis: coated pits, receptosomes and the Golgi Trends in Biochemical Sciences. 8: 250-254. DOI: 10.1016/0968-0004(83)90351-1 |
0.313 |
|
| 1982 |
Tyagi JS, Merlino GT, de Crombrugghe B, Pastan I. Chicken embryo extracts contain a factor that preferentially blocks the accumulation of RNA polymerase II transcripts in a cell-free system. The Journal of Biological Chemistry. 257: 13001-8. PMID 7130191 |
0.509 |
|
| 1982 |
Vogeli G, Ohkubo H, Sobel ME, Yamada Y, Pastan I, de Crombrugghe B. Structure of the promoter for chicken α2 type I collagen gene Proceedings of the National Academy of Sciences of the United States of America. 78: 5334-5338. PMID 6946474 DOI: 10.1073/pnas.78.9.5334 |
0.544 |
|
| 1982 |
Gorman CM, Merlino GT, Willingham MC, Pastan I, Howard BH. The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection Proceedings of the National Academy of Sciences of the United States of America. 79: 6777-6781. PMID 6294651 DOI: 10.1073/pnas.79.22.6777 |
0.363 |
|
| 1982 |
Horiuchi R, Johnson ML, Willingham MC, Pastan I, Cheng S. Affinity labeling of the plasma membrane 3,3',5-triiodo-L-thyronine receptor in GH3 cells. Proceedings of the National Academy of Sciences of the United States of America. 79: 5527-31. PMID 6291049 DOI: 10.1073/pnas.79.18.5527 |
0.339 |
|
| 1982 |
Pastan IH, Willingham M, de Crombrugghe B, Gottesman MM. Aging and cancer: cyclic 3', 5'-adenosine monophosphate and altered gene activity. National Cancer Institute Monograph. 60: 7-15. PMID 6289108 |
0.451 |
|
| 1982 |
Roth CW, Singh T, Pastan I, Gottesman MM. Rous sarcoma virus transformed cells are resistant to cyclic AMP. Journal of Cellular Physiology. 111: 42-8. PMID 6282904 DOI: 10.1002/jcp.1041110108 |
0.324 |
|
| 1982 |
Merlino GT, Tyagi JS, de Crombrugghe B, Pastan I. Transcription of the chicken alpha 2 (Type I) collagen gene by homologous cell-free extracts. The Journal of Biological Chemistry. 257: 7254-61. PMID 6282836 |
0.528 |
|
| 1981 |
Pretorius HT, Nandi PK, Lippoldt RE, Johnson ML, Keen JH, Pastan I, Edelhoch H. Molecular characterization of human clathrin. Biochemistry. 20: 2777-82. PMID 7248247 DOI: 10.1021/Bi00513A011 |
0.541 |
|
| 1981 |
Willingham MC, Yamada SS, Davies PJ, Rutherford AV, Gallo MG, Pastan I. Intracellular localization of actin in cultured fibroblasts by electron microscopic immunocytochemistry. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 29: 17-37. PMID 7009728 DOI: 10.1177/29.1.7009728 |
0.311 |
|
| 1981 |
Vogeli G, Ohkubo H, Avvedimento VE, Sullivan M, Yamada Y, Mudryj M, Pastan I, de Crombrugghe B. A repetitive structure in the chick alpha 2-collagen gene. Cold Spring Harbor Symposia On Quantitative Biology. 45: 777-83. PMID 6942950 DOI: 10.1101/Sqb.1981.045.01.096 |
0.52 |
|
| 1981 |
Merlino GT, Vogeli G, Yamamoto T, de Crombrugghe B, Pastan I. Accurate in vitro transcriptional initiation of the chick alpha 2 (Type I) collagen gene. The Journal of Biological Chemistry. 256: 11251-8. PMID 6270147 |
0.513 |
|
| 1981 |
Dickson LA, Ninomiya Y, Bernard MP, Pesciotta DM, Parsons J, Green G, Eikenberry EF, de Crombrugghe B, Vogeli G, Pastan I, Fietzek PP, Olsen BR. The exon/intron structure of the 3'-region of the pro alpha 2(I) collagen gene. The Journal of Biological Chemistry. 256: 8407-15. PMID 6267043 |
0.474 |
|
| 1981 |
LeCam A, Gottesman MM, Pastan I. Glycogen synthase activity in Chinese hamster ovary cells. Studies with wild-type and mutant cells defective in cyclic AMP-dependent protein kinase. Biochimica Et Biophysica Acta. 675: 94-100. PMID 6266497 DOI: 10.1016/0304-4165(81)90073-8 |
0.309 |
|
| 1981 |
Sobel ME, Yamamoto T, De Crombrugghe B, Pastan I. Regulation of procollagen messenger ribonucleic acid levels in Rous sarcoma virus transformed chick embryo fibroblasts Biochemistry. 20: 2678-2684. PMID 6263317 DOI: 10.1021/Bi00512A049 |
0.546 |
|
| 1981 |
Fagan JB, Sobel ME, Yamada KM, de Crombrugghe B, Pastan I. Effects of transformation on fibronectin gene expression using cloned fibronectin cDNA Journal of Biological Chemistry. 256: 520-525. PMID 6256355 |
0.469 |
|
| 1981 |
Maxfield FR, Willingham MC, Pastan I, Dragsten P, Cheng SY. Binding and mobility of the cell surface receptors for 3,3',5-triiodo-L-thyronine. Science (New York, N.Y.). 211: 63-5. PMID 6255563 |
0.465 |
|
| 1981 |
Maxfield FR, Willingham MC, Haigler HT, Dragsten P, Pastan IH. Binding, surface mobility, internalization, and degradation of rhodamine-labeled alpha 2-macroglobulin. Biochemistry. 20: 5353-8. PMID 6170323 DOI: 10.1021/Bi00521A041 |
0.481 |
|
| 1980 |
Yamada Y, Avvedimento VE, Mudryj M, Ohkubo H, Vogeli G, Irani M, Pastan I, de Crombrugghe B. The collagen gene: evidence for its evolutinary assembly by amplification of a DNA segment containing an exon of 54 bp. Cell. 22: 887-92. PMID 7460017 DOI: 10.1016/0092-8674(80)90565-6 |
0.537 |
|
| 1980 |
Vogeli G, Avvedimento EV, Sullivan M, Maizel JV, Lozano G, Adams SL, Pastan I, de Crombrugghe B. Isolation and characterization of genomic DNA coding for α2 type I collagen Nucleic Acids Research. 8: 1823-1837. PMID 7433131 DOI: 10.1093/Nar/8.8.1823 |
0.537 |
|
| 1980 |
Haigler HT, Willingham MC, Pastan I. Inhibitors of 125I-epidermal growth factor internalization Biochemical and Biophysical Research Communications. 94: 630-637. PMID 6967318 DOI: 10.1016/0006-291X(80)91279-6 |
0.312 |
|
| 1980 |
Ohkubo H, Vogeli G, Mudryj M, Avvedimento VE, Sullivan M, Pastan I, de Crombrugghe B. Isolation and characterization of overlapping genomic clones covering the chicken alpha 2 (type I) collagen gene. Proceedings of the National Academy of Sciences of the United States of America. 77: 7059-63. PMID 6452631 DOI: 10.1073/Pnas.77.12.7059 |
0.547 |
|
| 1980 |
Yamamoto T, de Crombrugghe B, Pastan I. Identification of a functional promoter in the long terminal repeat of Rous sarcoma virus. Cell. 22: 787-97. PMID 6257399 DOI: 10.1016/0092-8674(80)90555-3 |
0.551 |
|
| 1980 |
Davies PJA, Chabay R, Zech L, Berman M, Pastan I. Prostaglandin E1 binding and adenylate cyclase activation in normal and transformed fibroblasts Bba - General Subjects. 629: 282-291. PMID 6248120 DOI: 10.1016/0304-4165(80)90101-4 |
0.306 |
|
| 1980 |
Willingham MC, Pastan I, Shih TY, Scolnick EM. Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistry Cell. 19: 1005-1014. PMID 6247068 DOI: 10.1016/0092-8674(80)90091-4 |
0.304 |
|
| 1980 |
Gottesman MM, LeCam A, Bukowski M, Pastan I. Isolation of multiple classes of mutants of CHO cells resistant to cyclic AMP. Somatic Cell Genetics. 6: 45-61. PMID 6245473 DOI: 10.1007/BF01538695 |
0.304 |
|
| 1980 |
Yamamoto T, Sobel ME, Adams SL, Avvedimento VE, DiLauro R, Pastan I, de Crombrugghe B, Showalter A, Pesciotta D, Fietzek P, Olsen B. Construction of a recombinant bacterial plasmid containing pro-α1(I) collagen DNA sequences Journal of Biological Chemistry. 255: 2612-2615. PMID 6244285 |
0.467 |
|
| 1980 |
Haigler HT, Maxfield FR, Willingham MC, Pastan I. Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells. The Journal of Biological Chemistry. 255: 1239-41. PMID 6243633 |
0.499 |
|
| 1980 |
Willingham MC, Maxfield FR, Pastan I. Receptor-mediated endocytosis of alpha 2-macroglobulin in cultured fibroblasts. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 28: 818-23. PMID 6160180 DOI: 10.1177/28.8.6160180 |
0.547 |
|
| 1980 |
Avvedimento VE, Vogeli G, Yamada Y, Maizel JV, Pastan I, de Crombrugghe B. Correlation between splicing sites within an intron and their sequence complementarity with U1 RNA. Cell. 21: 689-96. PMID 6159982 DOI: 10.1016/0092-8674(80)90432-8 |
0.536 |
|
| 1980 |
Cheng SY, Maxfield FR, Robbins J, Willingham MC, Pastan IH. Receptor-mediated uptake of 3,3',5-triiodo-L-thyronine by cultured fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 77: 3425-9. PMID 6158047 DOI: 10.1073/Pnas.77.6.3425 |
0.487 |
|
| 1980 |
Willingham MC, Pastan I. The receptosome: an intermediate organelle of receptor mediated endocytosis in cultured fibroblasts. Cell. 21: 67-77. PMID 6157480 DOI: 10.1016/0092-8674(80)90115-4 |
0.308 |
|
| 1980 |
Davies PJ, Davies DR, Levitzki A, Maxfield FR, Milhaud P, Willingham MC, Pastan IH. Transglutaminase is essential in receptor-mediated endocytosis of alpha 2-macroglobulin and polypeptide hormones. Nature. 283: 162-7. PMID 6153122 DOI: 10.1038/283162A0 |
0.472 |
|
| 1980 |
Milhaud PG, Davies PJ, Pastan I, Gottesman MM. Regulation of transglutaminase activity in Chinese hamster ovary cells. Biochimica Et Biophysica Acta. 630: 476-84. PMID 6104988 DOI: 10.1016/0304-4165(80)90002-1 |
0.312 |
|
| 1980 |
Willingham MC, Jay G, Pastan I. Localization of the ASV src gene product to the plasma membrane of transformed cells by electron microscopic immunocytochemistry. Cell. 18: 125-34. PMID 228858 DOI: 10.1016/0092-8674(79)90361-1 |
0.325 |
|
| 1979 |
Fagan JB, Yamada KM, de Crombrugghe B, Pastan I. Partial purification and characterization of the messenger RNA for cell fibronectin. Nucleic Acids Research. 6: 3471-80. PMID 573888 DOI: 10.1093/nar/6.11.3471 |
0.613 |
|
| 1979 |
Pastan I. Cell transformation. Methods in Enzymology. 58: 368-70. PMID 423777 DOI: 10.1016/S0076-6879(79)58151-8 |
0.323 |
|
| 1979 |
Yamada KM, Olden K, Pastan I. Transformation-sensitive cell surface protein: isolation, characterization, and role in cellular morphology and adhesion. Annals of the New York Academy of Sciences. 312: 256-77. PMID 291364 DOI: 10.1111/j.1749-6632.1978.tb16807.x |
0.522 |
|
| 1979 |
LeCam A, Maxfield F, Willingham M, Pastan I. Insulin stimulation of amino acid transport in isolated rat hepatocytes is independent of hormone internalization. Biochemical and Biophysical Research Communications. 88: 873-81. PMID 223575 DOI: 10.1016/0006-291X(79)91490-6 |
0.507 |
|
| 1979 |
Willingham MC, Maxfield FR, Pastan IH. alpha 2 Macroglobulin binding to the plasma membrane of cultured fibroblasts. Diffuse binding followed by clustering in coated regions. The Journal of Cell Biology. 82: 614-25. PMID 92473 DOI: 10.1083/Jcb.82.3.614 |
0.472 |
|
| 1979 |
Maxfield FR, Willingham MC, Davies PJ, Pastan I. Amines inhibit the clustering of alpha2-macroglobulin and EGF on the fibroblast cell surface. Nature. 277: 661-3. PMID 85262 DOI: 10.1038/277661A0 |
0.528 |
|
| 1979 |
Maxfield FR, Davies PJ, Klempner L, Willingham MC, Pastan I. Epidermal growth factor stimulation of DNA synthesis is potentiated by compounds that inhibit its clustering in coated pits. Proceedings of the National Academy of Sciences of the United States of America. 76: 5731-5. PMID 42903 DOI: 10.1073/Pnas.76.11.5731 |
0.541 |
|
| 1978 |
Anderson WB, Jaworski CJ, Gallo M, Pastan I, Pouysségur J. Adenylate cyclase in a fibroblast mutant defective in glycolipid and glycoprotein synthesis. Nature. 275: 223-4. PMID 692696 DOI: 10.1038/275223A0 |
0.339 |
|
| 1978 |
Yamada KM, Schlesinger DH, Kennedy DW, Pastan I. Characterization of a major fibroblast cell surface glycoprotein. Biochemistry. 16: 5552-9. PMID 562674 DOI: 10.1021/bi00644a025 |
0.477 |
|
| 1978 |
Sobel ME, Yamamoto T, Adams SL, DiLauro R, Avvedimento VE, de Crombrugghe B, Pastan I. Construction of a recombinant bacterial plasmid containing a chick pro-α2 collagen gene sequence Proceedings of the National Academy of Sciences of the United States of America. 75: 5846-5850. PMID 366605 DOI: 10.1073/Pnas.75.12.5846 |
0.55 |
|
| 1978 |
Pratt RM, Pastan I. Decreased binding of epidermal growth factor to BALB/c 3T3 mutant cells defective in glycoprotein synthesis. Nature. 272: 68-70. PMID 305006 DOI: 10.1038/272068A0 |
0.37 |
|
| 1978 |
Pastan I, Willingham M. Cellular transformation and the 'morphologic phenotype' of transformed cells. Nature. 274: 645-50. PMID 209337 DOI: 10.1038/274645A0 |
0.333 |
|
| 1978 |
Maxfield FR, Schlessinger J, Shechter Y, Pastan I, Willingham MC. Collection of insulin, EGF and alpha2-macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization. Cell. 14: 805-10. PMID 80283 DOI: 10.1016/0092-8674(78)90336-7 |
0.535 |
|
| 1978 |
Howard BH, Adams SL, Sobel ME, Pastan I, de Crombrugghe B. Decreased levels of collagen mRNA in Rous sarcoma virus-transformed chick embryo fibroblasts Journal of Biological Chemistry. 253: 5869-5874. PMID 78927 |
0.5 |
|
| 1977 |
Willingham MC, Yamada KM, Yamada SS, Pouysségur J, Pastan I. Microfilament bundles and cell shape are related to adhesiveness to substratum and are dissociable from growth control in cultured fibroblasts. Cell. 10: 375-80. PMID 557370 DOI: 10.1016/0092-8674(77)90024-1 |
0.502 |
|
| 1977 |
Schlessinger J, Barak LS, Hammes GG, Yamada KM, Pastan I, Webb WW, Elson EL. Mobility and distribution of a cell surface glycoprotein and its interaction with other membrane components. Proceedings of the National Academy of Sciences of the United States of America. 74: 2909-13. PMID 331320 DOI: 10.1073/Pnas.74.7.2909 |
0.49 |
|
| 1977 |
Yamada KM, Yamada SS, Pastan I. Quantitation of a transformation-sensitive, adhesive cell surface glycoprotein. Decrease of several untransformed permanent cell lines. The Journal of Cell Biology. 74: 649-54. PMID 328519 DOI: 10.1083/jcb.74.2.649 |
0.521 |
|
| 1977 |
Pouysségur J, Willingham M, Pastan I. Role of cell surface carbohydrates and proteins in cell behavior: studies on the biochemical reversion of an N-acetylglucosamine-deficient fibroblast mutant. Proceedings of the National Academy of Sciences of the United States of America. 74: 243-7. PMID 264677 DOI: 10.1073/PNAS.74.1.243 |
0.337 |
|
| 1977 |
Adams SL, Sobel ME, Howard BH, Olden K, Yamada KM, de Crombrugghe B, Pastan I. Levels of translatable mRNAs for cell surface protein, collagen precursors, and two membrane proteins are altered in Rous sarcoma virus transformed chick embryo fibroblasts Proceedings of the National Academy of Sciences of the United States of America. 74: 3399-3403. PMID 198783 DOI: 10.1073/pnas.74.8.3399 |
0.644 |
|
| 1977 |
Yamada KM, Pastan I. The relationship between cell surface protein and glucose and alpha-aminoisobutyrate transport in transformed chick and mouse cells. Journal of Cellular Physiology. 89: 827-9. PMID 188852 DOI: 10.1002/jcp.1040890450 |
0.483 |
|
| 1977 |
Ostlund RE, Pastan I. The purification and quantitation of myosin from cultured cells. Biochimica Et Biophysica Acta. 453: 37-47. PMID 136988 DOI: 10.1016/0005-2795(76)90248-8 |
0.337 |
|
| 1976 |
Yamada KM, Yamada SS, Pastan I. The major cell surface glycoprotein of chick embryo fibroblasts is an agglutinin. Proceedings of the National Academy of Sciences of the United States of America. 72: 3158-62. PMID 1059102 DOI: 10.1073/pnas.72.8.3158 |
0.511 |
|
| 1976 |
Thomopoulos P, Roth J, Lovelace E, Pastan I. Insulin receptors in normal and transformed fibroblasts: relationship to growth and transformation Cell. 8: 417-423. PMID 954096 DOI: 10.1016/0092-8674(76)90154-9 |
0.386 |
|
| 1976 |
Yamada KM, Yamada SS, Pastan I. Cell surface protein partially restores morphology, adhesiveness, and contact inhibition of movement to transformed fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 73: 1217-21. PMID 177979 DOI: 10.1073/pnas.73.4.1217 |
0.5 |
|
| 1976 |
Pouysségur JM, Pastan I. Mutants of Balb/c 3T3 fibroblasts defective in adhesiveness to substratum: evidence for alteration in cell surface proteins. Proceedings of the National Academy of Sciences of the United States of America. 73: 544-8. PMID 174110 DOI: 10.1073/PNAS.73.2.544 |
0.339 |
|
| 1976 |
Pastan I. Cyclic AMP and the malignant transformation of cells. Advances in Metabolic Disorders. 8: 377-83. PMID 173162 DOI: 10.1016/B978-0-12-027308-9.50029-9 |
0.32 |
|
| 1976 |
Yamada KM, Ohanian SH, Pastan I. Cell surface protein decreases microvilli and ruffles on transformed mouse and chick cells. Cell. 9: 241-5. PMID 61821 DOI: 10.1016/0092-8674(76)90115-X |
0.492 |
|
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