cached image

Ira Pastan - Publications

Affiliations: 
National Institutes of Health, Bethesda, MD 
Area:
Molecular Biology
Website:
http://ccr.nci.nih.gov/staff/staff.asp?profileid=5782

325 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Kreitman RJ, Tallman MS, Robak T, Coutre S, Wilson WH, Stetler-Stevenson M, FitzGerald DJ, Santiago L, Gao G, Lanasa MC, Pastan I. Minimal residual hairy cell leukemia eradication with moxetumomab pasudotox: phase I results and long-term follow-up. Blood. PMID 29487070 DOI: 10.1182/blood-2017-09-803072  0.4
2016 Liu XF, Xiang L, Zhou Q, Carralot JP, Prunotto M, Niederfellner G, Pastan I. Actinomycin D enhances killing of cancer cells by immunotoxin RG7787 through activation of the extrinsic pathway of apoptosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 27601652 DOI: 10.1073/pnas.1611481113  0.44
2016 Antignani A, Mathews Griner L, Guha R, Simon N, Pasetto M, Keller J, Huang M, Angelus E, Pastan I, Ferrer M, FitzGerald DJ, Thomas CJ. Chemical Screens Identify Drugs that Enhance or Mitigate Cellular Responses to Antibody-Toxin Fusion Proteins. Plos One. 11: e0161415. PMID 27556570 DOI: 10.1371/journal.pone.0161415  0.4
2016 Kaplan G, Lee F, Onda M, Kolyvas E, Bhardwaj G, Baker D, Pastan I. Protection of the Furin Cleavage Site in Low-Toxicity Immunotoxins Based on Pseudomonas Exotoxin A. Toxins. 8. PMID 27463727 DOI: 10.3390/toxins8080217  0.44
2016 Awuah P, Bera TK, Folivi M, Chertov O, Pastan I. Reduced Shedding of Surface Mesothelin Improves Efficacy of Mesothelin Targeting Recombinant Immunotoxins. Molecular Cancer Therapeutics. PMID 27196771 DOI: 10.1158/1535-7163.MCT-15-0863  0.44
2016 Liang X, Schnaper HW, Matsusaka T, Pastan I, Ledbetter S, Hayashida T. Anti-TGF-β Antibody, 1D11, Ameliorates Glomerular Fibrosis in Mouse Models after the Onset of Proteinuria. Plos One. 11: e0155534. PMID 27187580 DOI: 10.1371/journal.pone.0155534  0.44
2016 Guha R, Mathews Griner LA, Keller JM, Zhang X, Fitzgerald D, Antignani A, Pastan I, Thomas CJ, Ferrer M. Ranking Differential Drug Activities from Dose-Response Synthetic Lethality Screens. Journal of Biomolecular Screening. PMID 27112173 DOI: 10.1177/1087057116644890  0.36
2016 Bao X, Chandramohan V, Reynolds RP, Norton JN, Wetsel WC, Rodriguiz RM, Aryal DK, McLendon RE, Levin ED, Petry NA, Zalutsky MR, Burnett BK, Kuan CT, Pastan IH, Bigner DD. Preclinical toxicity evaluation of a novel immunotoxin, D2C7-(scdsFv)-PE38KDEL, administered via intracerebral convection-enhanced delivery in rats. Investigational New Drugs. PMID 26728879 DOI: 10.1007/s10637-015-0318-3  0.44
2015 Ali-Rahmani F, FitzGerald DJ, Martin S, Patel P, Prunotto M, Ormanoglu P, Thomas C, Pastan I. Anticancer Effects of Mesothelin-targeted Immunotoxin Therapy are Regulated by Tyrosine Kinase DDR1. Cancer Research. PMID 26719540 DOI: 10.1158/0008-5472.CAN-15-2401  0.4
2015 Kreitman RJ, Pastan I. Immunoconjugates in the management of hairy cell leukemia. Best Practice & Research. Clinical Haematology. 28: 236-45. PMID 26614902 DOI: 10.1016/j.beha.2015.09.003  0.44
2015 Mazor R, Zhang J, Xiang L, Addissie S, Awuah P, Beers R, Hassan R, Pastan I. Recombinant Immunotoxin with T Cell Epitope Mutations that Greatly Reduce Immunogenicity for Treatment of Mesothelin Expressing Tumors. Molecular Cancer Therapeutics. PMID 26443804 DOI: 10.1158/1535-7163.MCT-15-0532  0.44
2015 Kreitman RJ, Stetler-Stevenson M, Jaffe ES, Conlon KC, Steinberg SM, Wilson WH, Waldmann TA, Pastan I. Complete remissions of adult T-cell leukemia with anti-CD25 recombinant immunotoxin LMB-2 and chemotherapy to block immunogenicity. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26350263 DOI: 10.1158/1078-0432.CCR-15-1412  0.44
2015 Lee JH, Kim H, Yao Z, Lee SJ, Szajek LP, Grasso L, Pastan I, Paik CH. Tumor and organ uptake of (64)Cu-labeled MORAb-009 (amatuximab), an anti-mesothelin antibody, by PET imaging and biodistribution studies. Nuclear Medicine and Biology. PMID 26307499 DOI: 10.1016/j.nucmedbio.2015.07.008  0.44
2015 Gottesman MM, Pastan IH. The Role of Multidrug Resistance Efflux Pumps in Cancer: Revisiting a JNCI Publication Exploring Expression of the MDR1 (P-glycoprotein) Gene. Journal of the National Cancer Institute. 107. PMID 26286731 DOI: 10.1093/jnci/djv222  0.44
2015 Stahl S, da Silva Mateus Seidl AR, Ducret A, Kux van Geijtenbeek S, Michel S, Racek T, Birzele F, Haas AK, Rueger R, Gerg M, Niederfellner G, Pastan I, Brinkmann U. Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor. Proceedings of the National Academy of Sciences of the United States of America. 112: 10732-7. PMID 26261303 DOI: 10.1073/pnas.1512863112  0.44
2015 Hara S, Kobayashi N, Sakamoto K, Ueno T, Manabe S, Takashima Y, Hamada J, Pastan I, Fukamizu A, Matsusaka T, Nagata M. Podocyte Injury-Driven Lipid Peroxidation Accelerates the Infiltration of Glomerular Foam Cells in Focal Segmental Glomerulosclerosis. The American Journal of Pathology. PMID 26072030 DOI: 10.1016/j.ajpath.2015.04.007  0.44
2015 Weldon JE, Skarzynski M, Therres JA, Ostovitz JR, Zhou H, Kreitman RJ, Pastan I. Designing the furin-cleavable linker in recombinant immunotoxins based on Pseudomonas exotoxin A. Bioconjugate Chemistry. 26: 1120-8. PMID 25997032 DOI: 10.1021/acs.bioconjchem.5b00190  0.44
2015 Zhang YF, Phung Y, Gao W, Kawa S, Hassan R, Pastan I, Ho M. New high affinity monoclonal antibodies recognize non-overlapping epitopes on mesothelin for monitoring and treating mesothelioma. Scientific Reports. 5: 9928. PMID 25996440 DOI: 10.1038/srep09928  0.44
2015 Müller N, Michen S, Tietze S, Töpfer K, Schulte A, Lamszus K, Schmitz M, Schackert G, Pastan I, Temme A. Engineering NK Cells Modified With an EGFRvIII-specific Chimeric Antigen Receptor to Overexpress CXCR4 Improves Immunotherapy of CXCL12/SDF-1α-secreting Glioblastoma. Journal of Immunotherapy (Hagerstown, Md. : 1997). 38: 197-210. PMID 25962108 DOI: 10.1097/CJI.0000000000000082  0.44
2015 Kalra N, Zhang J, Thomas A, Xi L, Cheung M, Talarchek J, Burkett S, Tsokos MG, Chen Y, Raffeld M, Miettinen M, Pastan I, Testa JR, Hassan R. Mesothelioma patient derived tumor xenografts with defined BAP1 mutations that mimic the molecular characteristics of human malignant mesothelioma. Bmc Cancer. 15: 376. PMID 25952750 DOI: 10.1186/s12885-015-1362-2  0.44
2015 Hollevoet K, Mason-Osann E, Müller F, Pastan I. Methylation-associated partial down-regulation of mesothelin causes resistance to anti-mesothelin immunotoxins in a pancreatic cancer cell line. Plos One. 10: e0122462. PMID 25803818 DOI: 10.1371/journal.pone.0122462  0.44
2015 Lindenberg L, Thomas A, Adler S, Mena E, Kurdziel K, Maltzman J, Wallin B, Hoffman K, Pastan I, Paik CH, Choyke P, Hassan R. Safety and biodistribution of 111In-amatuximab in patients with mesothelin expressing cancers using single photon emission computed tomography-computed tomography (SPECT-CT) imaging. Oncotarget. 6: 4496-504. PMID 25756664  0.44
2015 Shah NN, Stevenson MS, Yuan CM, Richards K, Delbrook C, Kreitman RJ, Pastan I, Wayne AS. Characterization of CD22 expression in acute lymphoblastic leukemia. Pediatric Blood & Cancer. 62: 964-9. PMID 25728039 DOI: 10.1002/pbc.25410  0.44
2015 Pasetto M, Antignani A, Ormanoglu P, Buehler E, Guha R, Pastan I, Martin SE, FitzGerald DJ. Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 112: E1135-42. PMID 25713356 DOI: 10.1073/pnas.1501958112  0.4
2015 Okabe M, Miyazaki Y, Niimura F, Pastan I, Nishiyama A, Yokoo T, Ichikawa I, Matsusaka T. Unilateral ureteral obstruction attenuates intrarenal angiotensin II generation induced by podocyte injury. American Journal of Physiology. Renal Physiology. 308: F932-7. PMID 25673808 DOI: 10.1152/ajprenal.00444.2014  0.44
2015 Alewine C, Hassan R, Pastan I. Advances in anticancer immunotoxin therapy. The Oncologist. 20: 176-85. PMID 25561510 DOI: 10.1634/theoncologist.2014-0358  0.44
2015 Manning ML, Mason-Osann E, Onda M, Pastan I. Bortezomib reduces pre-existing antibodies to recombinant immunotoxins in mice. Journal of Immunology (Baltimore, Md. : 1950). 194: 1695-701. PMID 25560410 DOI: 10.4049/jimmunol.1402324  0.44
2015 Acs P, Bauer PO, Mayer B, Bera T, Macallister R, Mezey E, Pastan I. A novel form of ciliopathy underlies hyperphagia and obesity in Ankrd26 knockout mice. Brain Structure & Function. 220: 1511-28. PMID 24633808 DOI: 10.1007/s00429-014-0741-9  0.44
2015 Kobayashi N, Ueno T, Ohashi K, Yamashita H, Takahashi Y, Sakamoto K, Manabe S, Hara S, Takashima Y, Dan T, Pastan I, Miyata T, Kurihara H, Matsusaka T, Reiser J, et al. Podocyte injury-driven intracapillary plasminogen activator inhibitor type 1 accelerates podocyte loss via uPAR-mediated β1-integrin endocytosis American Journal of Physiology - Renal Physiology. 308: F614-F626. DOI: 10.1152/ajprenal.00616.2014.  0.44
2015 Mason-Osann E, Hollevoet K, Niederfellner G, Pastan I. Quantification of recombinant immunotoxin delivery to solid tumors allows for direct comparison of in vivo and in vitro results Scientific Reports. 5. DOI: 10.1038/srep10832  0.44
2015 Mazor R, Tai CH, Lee B, Pastan I. Poor correlation between T-cell activation assays and HLA-DR binding prediction algorithms in an immunogenic fragment of Pseudomonas exotoxin A Journal of Immunological Methods. DOI: 10.1016/j.jim.2015.06.003  0.44
2015 Thomas A, Chen Y, Steinberg SM, Luo J, Pack S, Raffeld M, Abdullaev Z, Alewine C, Rajan A, Giaccone G, Pastan I, Miettinen M, Hassan R. High mesothelin expression in advanced lung adenocarcinoma is associated with KRAS mutations and a poor prognosis Oncotarget. 6: 11694-11703.  0.44
2015 Lindenberg L, Thomas A, Adler S, Mena E, Kurdziel K, Maltzman J, Wallin B, Hoffman K, Pastan I, Paik CH, Choyke P, Hassan R. Safety and biodistribution of 111In-amatuximab in patients with mesothelin expressing cancers using Single Photon Emission Computed Tomography-Computed Tomography (SPECT-CT) imaging Oncotarget. 6: 4496-4504.  0.44
2014 Pak Y, Pastan I, Kreitman RJ, Lee B. Effect of antigen shedding on targeted delivery of immunotoxins in solid tumors from a mathematical model. Plos One. 9: e110716. PMID 25343405 DOI: 10.1371/journal.pone.0110716  0.44
2014 Alewine C, Xiang L, Yamori T, Niederfellner G, Bosslet K, Pastan I. Efficacy of RG7787, a next-generation mesothelin-targeted immunotoxin, against triple-negative breast and gastric cancers. Molecular Cancer Therapeutics. 13: 2653-61. PMID 25239937 DOI: 10.1158/1535-7163.MCT-14-0132  0.44
2014 Hassan R, Kindler HL, Jahan T, Bazhenova L, Reck M, Thomas A, Pastan I, Parno J, O'Shannessy DJ, Fatato P, Maltzman JD, Wallin BA. Phase II clinical trial of amatuximab, a chimeric antimesothelin antibody with pemetrexed and cisplatin in advanced unresectable pleural mesothelioma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 5927-36. PMID 25231400 DOI: 10.1158/1078-0432.CCR-14-0804  0.44
2014 Bera TK, Onda M, Kreitman RJ, Pastan I. An improved recombinant Fab-immunotoxin targeting CD22 expressing malignancies. Leukemia Research. 38: 1224-9. PMID 25127689 DOI: 10.1016/j.leukres.2014.06.014  0.44
2014 Zhang J, Bera TK, Liu W, Du X, Alewine C, Hassan R, Pastan I. Megakaryocytic potentiating factor and mature mesothelin stimulate the growth of a lung cancer cell line in the peritoneal cavity of mice. Plos One. 9: e104388. PMID 25118887 DOI: 10.1371/journal.pone.0104388  0.44
2014 Hassan R, Sharon E, Thomas A, Zhang J, Ling A, Miettinen M, Kreitman RJ, Steinberg SM, Hollevoet K, Pastan I. Phase 1 study of the antimesothelin immunotoxin SS1P in combination with pemetrexed and cisplatin for front-line therapy of pleural mesothelioma and correlation of tumor response with serum mesothelin, megakaryocyte potentiating factor, and cancer antigen 125. Cancer. 120: 3311-9. PMID 24989332 DOI: 10.1002/cncr.28875  0.44
2014 Wright SE, Rewers-Felkins KA, Quinlin I, Chowdhury NI, Ahmed J, Eldridge PW, Srivastava SK, Pastan I. TGFα-PE38 enhances cytotoxic T-lymphocyte killing of breast cancer cells. Oncology Letters. 7: 2113-2117. PMID 24932299 DOI: 10.3892/ol.2014.1969  0.44
2014 Arons E, Adams S, Venzon DJ, Pastan I, Kreitman RJ. Class II human leucocyte antigen DRB1*11 in hairy cell leukaemia patients with and without haemolytic uraemic syndrome. British Journal of Haematology. 166: 729-38. PMID 24931452 DOI: 10.1111/bjh.12956  0.44
2014 Hollevoet K, Mason-Osann E, Liu XF, Imhof-Jung S, Niederfellner G, Pastan I. In vitro and in vivo activity of the low-immunogenic antimesothelin immunotoxin RG7787 in pancreatic cancer. Molecular Cancer Therapeutics. 13: 2040-9. PMID 24928849 DOI: 10.1158/1535-7163.MCT-14-0089-T  0.44
2014 Onda M, Ghoreschi K, Steward-Tharp S, Thomas C, O'Shea JJ, Pastan IH, FitzGerald DJ. Tofacitinib suppresses antibody responses to protein therapeutics in murine hosts. Journal of Immunology (Baltimore, Md. : 1950). 193: 48-55. PMID 24890727 DOI: 10.4049/jimmunol.1400063  0.44
2014 King C, Garza EN, Mazor R, Linehan JL, Pastan I, Pepper M, Baker D. Removing T-cell epitopes with computational protein design. Proceedings of the National Academy of Sciences of the United States of America. 111: 8577-82. PMID 24843166 DOI: 10.1073/pnas.1321126111  0.44
2014 Pastan I, Hassan R. Discovery of mesothelin and exploiting it as a target for immunotherapy. Cancer Research. 74: 2907-12. PMID 24824231 DOI: 10.1158/0008-5472.CAN-14-0337  0.44
2014 Mazor R, Eberle JA, Hu X, Vassall AN, Onda M, Beers R, Lee EC, Kreitman RJ, Lee B, Baker D, King C, Hassan R, Benhar I, Pastan I. Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes. Proceedings of the National Academy of Sciences of the United States of America. 111: 8571-6. PMID 24799704 DOI: 10.1073/pnas.1405153111  0.44
2014 Yamada S, Nakamura J, Asada M, Takase M, Matsusaka T, Iguchi T, Yamada R, Tanaka M, Higashi AY, Okuda T, Asada N, Fukatsu A, Kawachi H, Graf D, Muso E, ... ... Pastan I, et al. Twisted gastrulation, a BMP antagonist, exacerbates podocyte injury. Plos One. 9: e89135. PMID 24586548 DOI: 10.1371/journal.pone.0089135  0.44
2014 Wayne AS, Fitzgerald DJ, Kreitman RJ, Pastan I. Immunotoxins for leukemia. Blood. 123: 2470-7. PMID 24578503 DOI: 10.1182/blood-2014-01-492256  0.44
2014 Miyazaki Y, Shimizu A, Pastan I, Taguchi K, Naganuma E, Suzuki T, Hosoya T, Yokoo T, Saito A, Miyata T, Yamamoto M, Matsusaka T. Keap1 inhibition attenuates glomerulosclerosis. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 29: 783-91. PMID 24523358 DOI: 10.1093/ndt/gfu002  0.44
2014 Terrier B, Nagata S, Ise T, Rosenzwajg M, Pastan I, Klatzmann D, Saadoun D, Cacoub P. CD21(-/low) marginal zone B cells highly express Fc receptor-like 5 protein and are killed by anti-Fc receptor-like 5 immunotoxins in hepatitis C virus-associated mixed cryoglobulinemia vasculitis. Arthritis & Rheumatology (Hoboken, N.J.). 66: 433-43. PMID 24504816 DOI: 10.1002/art.38222  0.44
2014 Denton PW, Long JM, Wietgrefe SW, Sykes C, Spagnuolo RA, Snyder OD, Perkey K, Archin NM, Choudhary SK, Yang K, Hudgens MG, Pastan I, Haase AT, Kashuba AD, Berger EA, et al. Targeted cytotoxic therapy kills persisting HIV infected cells during ART. Plos Pathogens. 10: e1003872. PMID 24415939 DOI: 10.1371/journal.ppat.1003872  0.44
2014 Miyazaki Y, Shimizu A, Ichikawa I, Hosoya T, Pastan I, Matsusaka T. Mice are unable to endogenously regenerate podocytes during the repair of immunotoxin-induced glomerular injury. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 29: 1005-12. PMID 24322577 DOI: 10.1093/ndt/gft413  0.44
2014 Hollevoet K, Antignani A, Fitzgerald DJ, Pastan I. Combining the antimesothelin immunotoxin SS1P with the BH3-mimetic ABT-737 induces cell death in SS1P-resistant pancreatic cancer cells. Journal of Immunotherapy (Hagerstown, Md. : 1997). 37: 8-15. PMID 24316551 DOI: 10.1097/CJI.0000000000000010  0.44
2014 Matsusaka T, Niimura F, Pastan I, Shintani A, Nishiyama A, Ichikawa I. Podocyte injury enhances filtration of liver-derived angiotensinogen and renal angiotensin II generation. Kidney International. 85: 1068-77. PMID 24284520 DOI: 10.1038/ki.2013.453  0.44
2014 Sakamoto K, Ueno T, Kobayashi N, Hara S, Takashima Y, Pastan I, Matsusaka T, Nagata M. The direction and role of phenotypic transition between podocytes and parietal epithelial cells in focal segmental glomerulosclerosis. American Journal of Physiology. Renal Physiology. 306: F98-F104. PMID 24154691 DOI: 10.1152/ajprenal.00228.2013  0.44
2014 Liu XF, Xiang L, FitzGerald DJ, Pastan I. Antitumor effects of immunotoxins are enhanced by lowering HCK or treatment with SRC kinase inhibitors. Molecular Cancer Therapeutics. 13: 82-9. PMID 24145282 DOI: 10.1158/1535-7163.MCT-13-0726  0.44
2013 Hassan R, Miller AC, Sharon E, Thomas A, Reynolds JC, Ling A, Kreitman RJ, Miettinen MM, Steinberg SM, Fowler DH, Pastan I. Major cancer regressions in mesothelioma after treatment with an anti-mesothelin immunotoxin and immune suppression. Science Translational Medicine. 5: 208ra147. PMID 24154601 DOI: 10.1126/scitranslmed.3006941  0.44
2013 Mattoo AR, Pastan I, Fitzgerald D. Combination treatments with the PKC inhibitor, enzastaurin, enhance the cytotoxicity of the anti-mesothelin immunotoxin, SS1P. Plos One. 8: e75576. PMID 24130723 DOI: 10.1371/journal.pone.0075576  0.44
2013 Hu X, Wei H, Xiang L, Chertov O, Wayne AS, Bera TK, Pastan I. Methylation of the DPH1 promoter causes immunotoxin resistance in acute lymphoblastic leukemia cell line KOPN-8. Leukemia Research. 37: 1551-6. PMID 24070652 DOI: 10.1016/j.leukres.2013.08.005  0.44
2013 Molavi O, Xiong XB, Douglas D, Kneteman N, Nagata S, Pastan I, Chu Q, Lavasanifar A, Lai R. Anti-CD30 antibody conjugated liposomal doxorubicin with significantly improved therapeutic efficacy against anaplastic large cell lymphoma. Biomaterials. 34: 8718-25. PMID 23942212 DOI: 10.1016/j.biomaterials.2013.07.068  0.44
2013 Piao H, Kuan CT, Chandramohan V, Keir ST, Pegram CN, Bao X, MÃ¥nsson JE, Pastan IH, Bigner DD. Affinity-matured recombinant immunotoxin targeting gangliosides 3'-isoLM1 and 3',6'-isoLD1 on malignant gliomas. Mabs. 5: 748-62. PMID 23924792 DOI: 10.4161/mabs.25860  0.44
2013 Chandramohan V, Bao X, Keir ST, Pegram CN, Szafranski SE, Piao H, Wikstrand CJ, McLendon RE, Kuan CT, Pastan IH, Bigner DD. Construction of an immunotoxin, D2C7-(scdsFv)-PE38KDEL, targeting EGFRwt and EGFRvIII for brain tumor therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 4717-27. PMID 23857604 DOI: 10.1158/1078-0432.CCR-12-3891  0.44
2013 Huang YH, Terabe M, Pendleton CD, Stewart Khursigara D, Bera TK, Pastan I, Berzofsky JA. Identification and enhancement of HLA-A2.1-restricted CTL epitopes in a new human cancer antigen-POTE. Plos One. 8: e64365. PMID 23750208 DOI: 10.1371/journal.pone.0064365  0.44
2013 Choi BD, Pastan I, Bigner DD, Sampson JH. A novel bispecific antibody recruits T cells to eradicate tumors in the "immunologically privileged" central nervous system. Oncoimmunology. 2: e23639. PMID 23734318 DOI: 10.4161/onci.23639  0.44
2013 Yamaguchi T, Danjo T, Pastan I, Hikida T, Nakanishi S. Distinct roles of segregated transmission of the septo-habenular pathway in anxiety and fear. Neuron. 78: 537-44. PMID 23602500 DOI: 10.1016/j.neuron.2013.02.035  0.44
2013 Wei H, Bera TK, Wayne AS, Xiang L, Colantonio S, Chertov O, Pastan I. A modified form of diphthamide causes immunotoxin resistance in a lymphoma cell line with a deletion of the WDR85 gene. The Journal of Biological Chemistry. 288: 12305-12. PMID 23486472 DOI: 10.1074/jbc.M113.461343  0.44
2013 Ueno T, Kobayashi N, Nakayama M, Takashima Y, Ohse T, Pastan I, Pippin JW, Shankland SJ, Uesugi N, Matsusaka T, Nagata M. Aberrant Notch1-dependent effects on glomerular parietal epithelial cells promotes collapsing focal segmental glomerulosclerosis with progressive podocyte loss. Kidney International. 83: 1065-75. PMID 23447065 DOI: 10.1038/ki.2013.48  0.44
2013 Liu XF, FitzGerald DJ, Pastan I. The insulin receptor negatively regulates the action of Pseudomonas toxin-based immunotoxins and native Pseudomonas toxin. Cancer Research. 73: 2281-8. PMID 23348423 DOI: 10.1158/0008-5472.CAN-12-3436  0.44
2013 Choi BD, Kuan CT, Cai M, Archer GE, Mitchell DA, Gedeon PC, Sanchez-Perez L, Pastan I, Bigner DD, Sampson JH. Systemic administration of a bispecific antibody targeting EGFRvIII successfully treats intracerebral glioma. Proceedings of the National Academy of Sciences of the United States of America. 110: 270-5. PMID 23248284 DOI: 10.1073/pnas.1219817110  0.44
2013 Haso W, Lee DW, Shah NN, Stetler-Stevenson M, Yuan CM, Pastan IH, Dimitrov DS, Morgan RA, FitzGerald DJ, Barrett DM, Wayne AS, Mackall CL, Orentas RJ. Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia. Blood. 121: 1165-74. PMID 23243285 DOI: 10.1182/blood-2012-06-438002  0.44
2013 Weldon JE, Xiang L, Zhang J, Beers R, Walker DA, Onda M, Hassan R, Pastan I. A recombinant immunotoxin against the tumor-associated antigen mesothelin reengineered for high activity, low off-target toxicity, and reduced antigenicity. Molecular Cancer Therapeutics. 12: 48-57. PMID 23136186 DOI: 10.1158/1535-7163.MCT-12-0336  0.44
2013 Chandramohan V, Bao X, Kato Kaneko M, Kato Y, Keir ST, Szafranski SE, Kuan CT, Pastan IH, Bigner DD. Recombinant anti-podoplanin (NZ-1) immunotoxin for the treatment of malignant brain tumors. International Journal of Cancer. Journal International Du Cancer. 132: 2339-48. PMID 23115013 DOI: 10.1002/ijc.27919  0.44
2012 Zhang J, Qiu S, Zhang Y, Merino M, Fetsch P, Avital I, Filie A, Pastan I, Hassan R. Loss of mesothelin expression by mesothelioma cells grown in vitro determines sensitivity to anti-mesothelin immunotoxin SS1P. Anticancer Research. 32: 5151-8. PMID 23225411  0.44
2012 Mazor R, Vassall AN, Eberle JA, Beers R, Weldon JE, Venzon DJ, Tsang KY, Benhar I, Pastan I. Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A. Proceedings of the National Academy of Sciences of the United States of America. 109: E3597-603. PMID 23213206 DOI: 10.1073/pnas.1218138109  0.44
2012 Tortorella LL, Pipalia NH, Mukherjee S, Pastan I, Fitzgerald D, Maxfield FR. Efficiency of immunotoxin cytotoxicity is modulated by the intracellular itinerary. Plos One. 7: e47320. PMID 23056628 DOI: 10.1371/journal.pone.0047320  0.44
2012 Ma J, Tang WK, Esser L, Pastan I, Xia D. Characterization of crystals of an antibody-recognition fragment of the cancer differentiation antigen mesothelin in complex with the therapeutic antibody MORAb-009. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 68: 950-3. PMID 22869130 DOI: 10.1107/S1744309112028229  0.44
2012 Ma J, Tang WK, Esser L, Pastan I, Xia D. Recognition of mesothelin by the therapeutic antibody MORAb-009: structural and mechanistic insights. The Journal of Biological Chemistry. 287: 33123-31. PMID 22787150 DOI: 10.1074/jbc.M112.381756  0.44
2012 Liu W, Onda M, Lee B, Kreitman RJ, Hassan R, Xiang L, Pastan I. Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes. Proceedings of the National Academy of Sciences of the United States of America. 109: 11782-7. PMID 22753489 DOI: 10.1073/pnas.1209292109  0.44
2012 Wang S, Shin IS, Hancock H, Jang BS, Kim HS, Lee SM, Zderic V, Frenkel V, Pastan I, Paik CH, Dreher MR. Pulsed high intensity focused ultrasound increases penetration and therapeutic efficacy of monoclonal antibodies in murine xenograft tumors. Journal of Controlled Release : Official Journal of the Controlled Release Society. 162: 218-24. PMID 22732476 DOI: 10.1016/j.jconrel.2012.06.025  0.44
2012 Liu XF, Bera TK, Kahue C, Escobar T, Fei Z, Raciti GA, Pastan I. ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells. Plos One. 7: e38130. PMID 22666460 DOI: 10.1371/journal.pone.0038130  0.44
2012 Pak Y, Zhang Y, Pastan I, Lee B. Antigen shedding may improve efficiencies for delivery of antibody-based anticancer agents in solid tumors. Cancer Research. 72: 3143-52. PMID 22562466 DOI: 10.1158/0008-5472.CAN-11-3925  0.44
2012 Baskar S, Wiestner A, Wilson WH, Pastan I, Rader C. Targeting malignant B cells with an immunotoxin against ROR1. Mabs. 4: 349-61. PMID 22531447 DOI: 10.4161/mabs.19870  0.44
2012 Matsusaka T, Niimura F, Shimizu A, Pastan I, Saito A, Kobori H, Nishiyama A, Ichikawa I. Liver angiotensinogen is the primary source of renal angiotensin II. Journal of the American Society of Nephrology : Jasn. 23: 1181-9. PMID 22518004 DOI: 10.1681/ASN.2011121159  0.44
2012 Wei H, Xiang L, Wayne AS, Chertov O, FitzGerald DJ, Bera TK, Pastan I. Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy. Proceedings of the National Academy of Sciences of the United States of America. 109: 6898-903. PMID 22509046 DOI: 10.1073/pnas.1204523109  0.44
2012 Margalit M, Yogev L, Yavetz H, Lehavi O, Hauser R, Botchan A, Barda S, Levitin F, Weiss M, Pastan I, Wreschner DH, Paz G, Kleiman SE. Involvement of the prostate and testis expression (PATE)-like proteins in sperm-oocyte interaction. Human Reproduction (Oxford, England). 27: 1238-48. PMID 22402205 DOI: 10.1093/humrep/des064  0.44
2012 Chandramohan V, Sampson JH, Pastan I, Bigner DD. Toxin-based targeted therapy for malignant brain tumors. Clinical & Developmental Immunology. 2012: 480429. PMID 22400035 DOI: 10.1155/2012/480429  0.44
2012 Kreitman RJ, Tallman MS, Robak T, Coutre S, Wilson WH, Stetler-Stevenson M, Fitzgerald DJ, Lechleider R, Pastan I. Phase I trial of anti-CD22 recombinant immunotoxin moxetumomab pasudotox (CAT-8015 or HA22) in patients with hairy cell leukemia. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 30: 1822-8. PMID 22355053 DOI: 10.1200/JCO.2011.38.1756  0.44
2012 Kelly RJ, Sharon E, Pastan I, Hassan R. Mesothelin-targeted agents in clinical trials and in preclinical development. Molecular Cancer Therapeutics. 11: 517-25. PMID 22351743 DOI: 10.1158/1535-7163.MCT-11-0454  0.44
2012 Mehta AI, Choi BD, Ajay D, Raghavan R, Brady M, Friedman AH, Pastan I, Bigner DD, Sampson JH. Convection enhanced delivery of macromolecules for brain tumors. Current Drug Discovery Technologies. 9: 305-10. PMID 22339074  0.44
2012 Pastan I, Zhang Y. Modulating mesothelin shedding to improve therapy. Oncotarget. 3: 114-5. PMID 22337812  0.44
2012 Bera TK, Walker DA, Sherins RJ, Pastan I. POTE protein, a cancer-testis antigen, is highly expressed in spermatids in human testis and is associated with apoptotic cells. Biochemical and Biophysical Research Communications. 417: 1271-4. PMID 22234308 DOI: 10.1016/j.bbrc.2011.12.125  0.44
2012 Biberacher V, Decker T, Oelsner M, Wagner M, Bogner C, Schmidt B, Kreitman RJ, Peschel C, Pastan I, Meyer Zum Büschenfelde C, Ringshausen I. The cytotoxicity of anti-CD22 immunotoxin is enhanced by bryostatin 1 in B-cell lymphomas through CD22 upregulation and PKC-βII depletion. Haematologica. 97: 771-9. PMID 22180432 DOI: 10.3324/haematol.2011.049155  0.44
2012 Jang BS, Lee SM, Kim HS, Shin IS, Razjouyan F, Wang S, Yao Z, Pastan I, Dreher MR, Paik CH. Combined-modality radioimmunotherapy: synergistic effect of paclitaxel and additive effect of bevacizumab. Nuclear Medicine and Biology. 39: 472-83. PMID 22172384 DOI: 10.1016/j.nucmedbio.2011.10.020  0.44
2012 Sharon E, Zhang J, Hollevoet K, Steinberg SM, Pastan I, Onda M, Gaedcke J, Ghadimi BM, Ried T, Hassan R. Serum mesothelin and megakaryocyte potentiating factor in pancreatic and biliary cancers. Clinical Chemistry and Laboratory Medicine : Cclm / Fescc. 50: 721-5. PMID 22149739 DOI: 10.1515/CCLM.2011.816  0.44
2012 Liu W, Onda M, Kim C, Xiang L, Weldon JE, Lee B, Pastan I. A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity. Protein Engineering, Design & Selection : Peds. 25: 1-6. PMID 22101015 DOI: 10.1093/protein/gzr053  0.44
2012 Singh R, Zhang Y, Pastan I, Kreitman RJ. Synergistic antitumor activity of anti-CD25 recombinant immunotoxin LMB-2 with chemotherapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 152-60. PMID 22068660 DOI: 10.1158/1078-0432.CCR-11-1839  0.44
2012 Liu XF, Xiang L, Zhang Y, Becker KG, Bera TK, Pastan I. CAPC negatively regulates NF-κB activation and suppresses tumor growth and metastasis. Oncogene. 31: 1673-82. PMID 21822313 DOI: 10.1038/onc.2011.355  0.44
2011 Mehta AI, Choi BD, Raghavan R, Brady M, Friedman AH, Bigner DD, Pastan I, Sampson JH. Imaging of convection enhanced delivery of toxins in humans. Toxins. 3: 201-6. PMID 22069706 DOI: 10.3390/toxins3030201  0.44
2011 Kawa S, Onda M, Ho M, Kreitman RJ, Bera TK, Pastan I. The improvement of an anti-CD22 immunotoxin: conversion to single-chain and disulfide stabilized form and affinity maturation by alanine scan. Mabs. 3: 479-86. PMID 22048691 DOI: 10.4161/mabs.3.5.17228  0.44
2011 Kreitman RJ, Pastan I. Antibody fusion proteins: anti-CD22 recombinant immunotoxin moxetumomab pasudotox. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 6398-405. PMID 22003067 DOI: 10.1158/1078-0432.CCR-11-0487  0.44
2011 FitzGerald DJ, Wayne AS, Kreitman RJ, Pastan I. Treatment of hematologic malignancies with immunotoxins and antibody-drug conjugates. Cancer Research. 71: 6300-9. PMID 21998010 DOI: 10.1158/0008-5472.CAN-11-1374  0.44
2011 Ackerman ME, Lai JI, Pastan I, Wittrup KD. Exploiting bias in a non-immune human antibody library to predict antigenicity. Protein Engineering, Design & Selection : Peds. 24: 845-53. PMID 21908549 DOI: 10.1093/protein/gzr046  0.44
2011 Raciti GA, Bera TK, Gavrilova O, Pastan I. Partial inactivation of Ankrd26 causes diabetes with enhanced insulin responsiveness of adipose tissue in mice. Diabetologia. 54: 2911-22. PMID 21842266 DOI: 10.1007/s00125-011-2263-9  0.44
2011 Du X, Xiang L, Mackall C, Pastan I. Killing of resistant cancer cells with low Bak by a combination of an antimesothelin immunotoxin and a TRAIL Receptor 2 agonist antibody. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 5926-34. PMID 21813632 DOI: 10.1158/1078-0432.CCR-11-1235  0.44
2011 Murata K, Imai M, Nakanishi S, Watanabe D, Pastan I, Kobayashi K, Nihira T, Mochizuki H, Yamada S, Mori K, Yamaguchi M. Compensation of depleted neuronal subsets by new neurons in a local area of the adult olfactory bulb. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10540-57. PMID 21775599 DOI: 10.1523/JNEUROSCI.1285-11.2011  0.44
2011 Zhang Y, Chertov O, Zhang J, Hassan R, Pastan I. Cytotoxic activity of immunotoxin SS1P is modulated by TACE-dependent mesothelin shedding. Cancer Research. 71: 5915-22. PMID 21775520 DOI: 10.1158/0008-5472.CAN-11-0466  0.44
2011 Shin IS, Lee SM, Kim HS, Yao Z, Regino C, Sato N, Cheng KT, Hassan R, Campo MF, Albone EF, Choyke PL, Pastan I, Paik CH. Effect of chelator conjugation level and injection dose on tumor and organ uptake of 111In-labeled MORAb-009, an anti-mesothelin antibody. Nuclear Medicine and Biology. 38: 1119-27. PMID 21741258 DOI: 10.1016/j.nucmedbio.2011.05.003  0.44
2011 Matsusaka T, Sandgren E, Shintani A, Kon V, Pastan I, Fogo AB, Ichikawa I. Podocyte injury damages other podocytes. Journal of the American Society of Nephrology : Jasn. 22: 1275-85. PMID 21719786 DOI: 10.1681/ASN.2010090963  0.44
2011 Fei Z, Bera TK, Liu X, Xiang L, Pastan I. Ankrd26 gene disruption enhances adipogenesis of mouse embryonic fibroblasts. The Journal of Biological Chemistry. 286: 27761-8. PMID 21669876 DOI: 10.1074/jbc.M111.248435  0.44
2011 Kreitman RJ, Arons E, Stetler-Stevenson M, Fitzgerald DJ, Wilson WH, Pastan I. Recombinant immunotoxins and other therapies for relapsed/refractory hairy cell leukemia. Leukemia & Lymphoma. 52: 82-6. PMID 21599609 DOI: 10.3109/10428194.2011.565843  0.44
2011 Fitzgerald DJ, Moskatel E, Ben-Josef G, Traini R, Tendler T, Sharma A, Antignani A, Mussai F, Wayne A, Kreitman RJ, Pastan I. Enhancing immunotoxin cell-killing activity via combination therapy with ABT-737. Leukemia & Lymphoma. 52: 79-81. PMID 21599608 DOI: 10.3109/10428194.2011.569961  0.44
2011 Weldon JE, Pastan I. A guide to taming a toxin--recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer. The Febs Journal. 278: 4683-700. PMID 21585657 DOI: 10.1111/j.1742-4658.2011.08182.x  0.44
2011 Mossoba ME, Onda M, Taylor J, Massey PR, Treadwell S, Sharon E, Hassan R, Pastan I, Fowler DH. Pentostatin plus cyclophosphamide safely and effectively prevents immunotoxin immunogenicity in murine hosts. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 3697-705. PMID 21521777 DOI: 10.1158/1078-0432.CCR-11-0493  0.44
2011 Pastan I, Onda M, Weldon J, Fitzgerald D, Kreitman R. Immunotoxins with decreased immunogenicity and improved activity. Leukemia & Lymphoma. 52: 87-90. PMID 21504287 DOI: 10.3109/10428194.2011.573039  0.44
2011 Onda M, Beers R, Xiang L, Lee B, Weldon JE, Kreitman RJ, Pastan I. Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes. Proceedings of the National Academy of Sciences of the United States of America. 108: 5742-7. PMID 21436054 DOI: 10.1073/pnas.1102746108  0.44
2011 Matsusaka T, Kobayashi K, Kon V, Pastan I, Fogo AB, Ichikawa I. Glomerular sclerosis is prevented during urinary tract obstruction due to podocyte protection. American Journal of Physiology. Renal Physiology. 300: F792-800. PMID 21177778 DOI: 10.1152/ajprenal.00570.2010  0.44
2011 Kuan CT, Wakiya K, Keir ST, Li J, Herndon JE, Pastan I, Bigner DD. Affinity-matured anti-glycoprotein NMB recombinant immunotoxins targeting malignant gliomas and melanomas. International Journal of Cancer. Journal International Du Cancer. 129: 111-21. PMID 20824708 DOI: 10.1002/ijc.25645  0.44
2011 Ho M, Feng M, Fisher RJ, Rader C, Pastan I. A novel high-affinity human monoclonal antibody to mesothelin. International Journal of Cancer. Journal International Du Cancer. 128: 2020-30. PMID 20635390 DOI: 10.1002/ijc.25557  0.44
2011 Lechleider R, Pastan I. Advances in the development of Anti-CD22 immunotoxins containing Pseudomonas exotoxin for treatment of hematologic malignancies Journal of Cancer Science and Therapy. 3: 50-52. DOI: 10.4172/1948-5956.1000057  0.44
2010 Hassan R, Cohen SJ, Phillips M, Pastan I, Sharon E, Kelly RJ, Schweizer C, Weil S, Laheru D. Phase I clinical trial of the chimeric anti-mesothelin monoclonal antibody MORAb-009 in patients with mesothelin-expressing cancers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 6132-8. PMID 21037025 DOI: 10.1158/1078-0432.CCR-10-2275  0.44
2010 Berger EA, Pastan I. Immunotoxin complementation of HAART to deplete persisting HIV-infected cell reservoirs. Plos Pathogens. 6: e1000803. PMID 20548940 DOI: 10.1371/journal.ppat.1000803  0.44
2010 Mussai F, Campana D, Bhojwani D, Stetler-Stevenson M, Steinberg SM, Wayne AS, Pastan I. Cytotoxicity of the anti-CD22 immunotoxin HA22 (CAT-8015) against paediatric acute lymphoblastic leukaemia. British Journal of Haematology. 150: 352-8. PMID 20528877 DOI: 10.1111/j.1365-2141.2010.08251.x  0.44
2010 Du X, Youle RJ, FitzGerald DJ, Pastan I. Pseudomonas exotoxin A-mediated apoptosis is Bak dependent and preceded by the degradation of Mcl-1. Molecular and Cellular Biology. 30: 3444-52. PMID 20457813 DOI: 10.1128/MCB.00813-09  0.44
2010 Hansen JK, Weldon JE, Xiang L, Beers R, Onda M, Pastan I. A recombinant immunotoxin targeting CD22 with low immunogenicity, low nonspecific toxicity, and high antitumor activity in mice. Journal of Immunotherapy (Hagerstown, Md. : 1997). 33: 297-304. PMID 20445350 DOI: 10.1097/CJI.0b013e3181cd1164  0.44
2010 Luther N, Cheung NK, Souliopoulos EP, Karampelas I, Karempelas I, Bassiri D, Edgar MA, Guo HF, Pastan I, Gutin PH, Souweidane MM. Interstitial infusion of glioma-targeted recombinant immunotoxin 8H9scFv-PE38. Molecular Cancer Therapeutics. 9: 1039-46. PMID 20371725 DOI: 10.1158/1535-7163.MCT-09-0996  0.44
2010 Wayne AS, Kreitman RJ, Findley HW, Lew G, Delbrook C, Steinberg SM, Stetler-Stevenson M, Fitzgerald DJ, Pastan I. Anti-CD22 immunotoxin RFB4(dsFv)-PE38 (BL22) for CD22-positive hematologic malignancies of childhood: preclinical studies and phase I clinical trial. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 1894-903. PMID 20215554 DOI: 10.1158/1078-0432.CCR-09-2980  0.44
2010 Matsusaka T, Asano T, Niimura F, Kinomura M, Shimizu A, Shintani A, Pastan I, Fogo AB, Ichikawa I. Angiotensin receptor blocker protection against podocyte-induced sclerosis is podocyte angiotensin II type 1 receptor-independent. Hypertension. 55: 967-73. PMID 20142565 DOI: 10.1161/HYPERTENSIONAHA.109.141994  0.44
2010 Zhang Y, Hansen JK, Xiang L, Kawa S, Onda M, Ho M, Hassan R, Pastan I. A flow cytometry method to quantitate internalized immunotoxins shows that taxol synergistically increases cellular immunotoxins uptake. Cancer Research. 70: 1082-9. PMID 20103626 DOI: 10.1158/0008-5472.CAN-09-2405  0.44
2010 Ding D, Kanaly CW, Bigner DD, Cummings TJ, Herndon JE, Pastan I, Raghavan R, Sampson JH. Convection-enhanced delivery of free gadolinium with the recombinant immunotoxin MR1-1. Journal of Neuro-Oncology. 98: 1-7. PMID 19898744 DOI: 10.1007/s11060-009-0046-7  0.44
2010 Bogner C, Dechow T, Ringshausen I, Wagner M, Oelsner M, Lutzny G, Licht T, Peschel C, Pastan I, Kreitman RJ, Decker T. Immunotoxin BL22 induces apoptosis in mantle cell lymphoma (MCL) cells dependent on Bcl-2 expression. British Journal of Haematology. 148: 99-109. PMID 19821820 DOI: 10.1111/j.1365-2141.2009.07939.x  0.44
2010 Hassan R, Schweizer C, Lu KF, Schuler B, Remaley AT, Weil SC, Pastan I. Inhibition of mesothelin-CA-125 interaction in patients with mesothelioma by the anti-mesothelin monoclonal antibody MORAb-009: Implications for cancer therapy. Lung Cancer (Amsterdam, Netherlands). 68: 455-9. PMID 19744744 DOI: 10.1016/j.lungcan.2009.07.016  0.44
2010 Cereda V, Poole DJ, Palena C, Das S, Bera TK, Remondo C, Gulley JL, Arlen PM, Yokokawa J, Pastan I, Schlom J, Tsang KY. New gene expressed in prostate: a potential target for T cell-mediated prostate cancer immunotherapy. Cancer Immunology, Immunotherapy : Cii. 59: 63-71. PMID 19495750 DOI: 10.1007/s00262-009-0723-6  0.44
2009 Xiao X, Ho M, Zhu Z, Pastan I, Dimitrov DS. Identification and characterization of fully human anti-CD22 monoclonal antibodies. Mabs. 1: 297-303. PMID 20065646 DOI: 10.4161/mabs.1.3.8113  0.44
2009 Kreitman RJ, Fitzgerald DJ, Pastan I. Approach to the patient after relapse of hairy cell leukemia. Leukemia & Lymphoma. 50: 32-7. PMID 19814696 DOI: 10.3109/10428190903142216  0.44
2009 Nagata S, Pastan I. Removal of B cell epitopes as a practical approach for reducing the immunogenicity of foreign protein-based therapeutics. Advanced Drug Delivery Reviews. 61: 977-85. PMID 19679153 DOI: 10.1016/j.addr.2009.07.014  0.44
2009 Kreitman RJ, Hassan R, Fitzgerald DJ, Pastan I. Phase I trial of continuous infusion anti-mesothelin recombinant immunotoxin SS1P. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 5274-9. PMID 19671873 DOI: 10.1158/1078-0432.CCR-09-0062  0.44
2009 Liu XF, Bera TK, Liu LJ, Pastan I. A primate-specific POTE-actin fusion protein plays a role in apoptosis. Apoptosis : An International Journal On Programmed Cell Death. 14: 1237-44. PMID 19669888 DOI: 10.1007/s10495-009-0392-0  0.44
2009 Ho M, Pastan I. Display and selection of scFv antibodies on HEK-293T cells. Methods in Molecular Biology (Clifton, N.J.). 562: 99-113. PMID 19554290 DOI: 10.1007/978-1-60327-302-2_8  0.44
2009 Hahn Y, Kim DS, Pastan IH, Lee B. Anoctamin and transmembrane channel-like proteins are evolutionarily related. International Journal of Molecular Medicine. 24: 51-5. PMID 19513534 DOI: 10.3892/ijmm_00000205  0.44
2009 Nagata S, Ise T, Pastan I. Fc receptor-like 3 protein expressed on IL-2 nonresponsive subset of human regulatory T cells. Journal of Immunology (Baltimore, Md. : 1950). 182: 7518-26. PMID 19494275 DOI: 10.4049/jimmunol.0802230  0.44
2009 Feng Y, Xiao X, Zhu Z, Streaker E, Ho M, Pastan I, Dimitrov DS. A novel human monoclonal antibody that binds with high affinity to mesothelin-expressing cells and kills them by antibody-dependent cell-mediated cytotoxicity. Molecular Cancer Therapeutics. 8: 1113-8. PMID 19417159 DOI: 10.1158/1535-7163.MCT-08-0945  0.44
2009 Kreitman RJ, Stetler-Stevenson M, Margulies I, Noel P, Fitzgerald DJ, Wilson WH, Pastan I. Phase II trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with hairy cell leukemia. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 27: 2983-90. PMID 19414673 DOI: 10.1200/JCO.2008.20.2630  0.44
2009 Ho M, Pastan I. In vitro antibody affinity maturation targeting germline hotspots. Methods in Molecular Biology (Clifton, N.J.). 525: 293-308, xiv. PMID 19252855 DOI: 10.1007/978-1-59745-554-1_15  0.44
2009 Ho M, Pastan I. Mammalian cell display for antibody engineering. Methods in Molecular Biology (Clifton, N.J.). 525: 337-52, xiv. PMID 19252852 DOI: 10.1007/978-1-59745-554-1_18  0.44
2009 Anaganti S, Hansen JK, Ha D, Hahn Y, Chertov O, Pastan I, Bera TK. Non-AUG translational initiation of a short CAPC transcript generating protein isoform. Biochemical and Biophysical Research Communications. 380: 508-13. PMID 19250639 DOI: 10.1016/j.bbrc.2009.01.089  0.44
2009 Carpenito C, Milone MC, Hassan R, Simonet JC, Lakhal M, Suhoski MM, Varela-Rohena A, Haines KM, Heitjan DF, Albelda SM, Carroll RG, Riley JL, Pastan I, June CH. Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains. Proceedings of the National Academy of Sciences of the United States of America. 106: 3360-5. PMID 19211796 DOI: 10.1073/pnas.0813101106  0.44
2009 Alderson RF, Kreitman RJ, Chen T, Yeung P, Herbst R, Fox JA, Pastan I. CAT-8015: a second-generation pseudomonas exotoxin A-based immunotherapy targeting CD22-expressing hematologic malignancies. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 832-9. PMID 19188153 DOI: 10.1158/1078-0432.CCR-08-1456  0.44
2009 Sathyanarayana BK, Hahn Y, Patankar MS, Pastan I, Lee B. Mesothelin, Stereocilin, and Otoancorin are predicted to have superhelical structures with ARM-type repeats. Bmc Structural Biology. 9: 1. PMID 19128473 DOI: 10.1186/1472-6807-9-1  0.44
2009 Weldon JE, Xiang L, Chertov O, Margulies I, Kreitman RJ, FitzGerald DJ, Pastan I. A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity. Blood. 113: 3792-800. PMID 18988862 DOI: 10.1182/blood-2008-08-173195  0.44
2008 Zhang Y, Pastan I. High shed antigen levels within tumors: an additional barrier to immunoconjugate therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 7981-6. PMID 19088013 DOI: 10.1158/1078-0432.CCR-08-0324  0.44
2008 Motoyoshi Y, Matsusaka T, Saito A, Pastan I, Willnow TE, Mizutani S, Ichikawa I. Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuria. Kidney International. 74: 1262-9. PMID 18769366 DOI: 10.1038/ki.2008.405  0.44
2008 Onda M, Beers R, Xiang L, Nagata S, Wang QC, Pastan I. An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes. Proceedings of the National Academy of Sciences of the United States of America. 105: 11311-6. PMID 18678888 DOI: 10.1073/pnas.0804851105  0.44
2008 Das S, Hahn Y, Walker DA, Nagata S, Willingham MC, Peehl DM, Bera TK, Lee B, Pastan I. Topology of NGEP, a prostate-specific cell:cell junction protein widely expressed in many cancers of different grade level. Cancer Research. 68: 6306-12. PMID 18676855 DOI: 10.1158/0008-5472.CAN-08-0870  0.44
2008 Du X, Beers R, Fitzgerald DJ, Pastan I. Differential cellular internalization of anti-CD19 and -CD22 immunotoxins results in different cytotoxic activity. Cancer Research. 68: 6300-5. PMID 18676854 DOI: 10.1158/0008-5472.CAN-08-0461  0.44
2008 Hafkemeyer P, Brinkmann U, Brinkmann E, Pastan I, Blum HE, Baumert TF. Pseudomonas exotoxin antisense RNA selectively kills hepatitis B virus infected cells. World Journal of Gastroenterology : Wjg. 14: 2810-7. PMID 18473403 DOI: 10.3748/wjg.14.2810  0.44
2008 Bera TK, Saint Fleur A, Ha D, Yamada M, Lee Y, Lee B, Hahn Y, Kaufman DS, Pera M, Pastan I. Selective POTE paralogs on chromosome 2 are expressed in human embryonic stem cells. Stem Cells and Development. 17: 325-32. PMID 18447647 DOI: 10.1089/scd.2007.0079  0.44
2008 Epel M, Carmi I, Soueid-Baumgarten S, Oh SK, Bera T, Pastan I, Berzofsky J, Reiter Y. Targeting TARP, a novel breast and prostate tumor-associated antigen, with T cell receptor-like human recombinant antibodies. European Journal of Immunology. 38: 1706-20. PMID 18446790 DOI: 10.1002/eji.200737524  0.44
2008 Sampson JH, Akabani G, Archer GE, Berger MS, Coleman RE, Friedman AH, Friedman HS, Greer K, Herndon JE, Kunwar S, McLendon RE, Paolino A, Petry NA, Provenzale JM, Reardon DA, ... ... Pastan I, et al. Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors. Neuro-Oncology. 10: 320-9. PMID 18403491 DOI: 10.1215/15228517-2008-012  0.44
2008 Levitin F, Weiss M, Hahn Y, Stern O, Papke RL, Matusik R, Nandana SR, Ziv R, Pichinuk E, Salame S, Bera T, Vincent J, Lee B, Pastan I, Wreschner DH. PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activity. The Journal of Biological Chemistry. 283: 16928-39. PMID 18387948 DOI: 10.1074/jbc.M801454200  0.44
2008 Khaibullina A, Jang BS, Sun H, Le N, Yu S, Frenkel V, Carrasquillo JA, Pastan I, Li KC, Paik CH. Pulsed high-intensity focused ultrasound enhances uptake of radiolabeled monoclonal antibody to human epidermoid tumor in nude mice. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 49: 295-302. PMID 18199622 DOI: 10.2967/jnumed.107.046888  0.44
2008 Bera TK, Liu XF, Yamada M, Gavrilova O, Mezey E, Tessarollo L, Anver M, Hahn Y, Lee B, Pastan I. A model for obesity and gigantism due to disruption of the Ankrd26 gene. Proceedings of the National Academy of Sciences of the United States of America. 105: 270-5. PMID 18162531 DOI: 10.1073/pnas.0710978105  0.44
2008 Ise T, Das S, Nagata S, Maeda H, Lee Y, Onda M, Anver MR, Bera TK, Pastan I. Expression of POTE protein in human testis detected by novel monoclonal antibodies. Biochemical and Biophysical Research Communications. 365: 603-8. PMID 17996727 DOI: 10.1016/j.bbrc.2007.10.195  0.44
2008 Du X, Nagata S, Ise T, Stetler-Stevenson M, Pastan I. FCRL1 on chronic lymphocytic leukemia, hairy cell leukemia, and B-cell non-Hodgkin lymphoma as a target of immunotoxins. Blood. 111: 338-43. PMID 17895404 DOI: 10.1182/blood-2007-07-102350  0.44
2008 Ochiai H, Archer GE, Herndon JE, Kuan CT, Mitchell DA, Bigner DD, Pastan IH, Sampson JH. EGFRvIII-targeted immunotoxin induces antitumor immunity that is inhibited in the absence of CD4+ and CD8+ T cells. Cancer Immunology, Immunotherapy : Cii. 57: 115-21. PMID 17634939 DOI: 10.1007/s00262-007-0363-7  0.44
2007 Hassan R, Ebel W, Routhier EL, Patel R, Kline JB, Zhang J, Chao Q, Jacob S, Turchin H, Gibbs L, Phillips MD, Mudali S, Iacobuzio-Donahue C, Jaffee EM, Moreno M, ... Pastan I, et al. Preclinical evaluation of MORAb-009, a chimeric antibody targeting tumor-associated mesothelin. Cancer Immunity. 7: 20. PMID 18088084  0.44
2007 Zhang Y, Xiang L, Hassan R, Pastan I. Immunotoxin and Taxol synergy results from a decrease in shed mesothelin levels in the extracellular space of tumors. Proceedings of the National Academy of Sciences of the United States of America. 104: 17099-104. PMID 17940013 DOI: 10.1073/pnas.0708101104  0.44
2007 Das S, Ise T, Nagata S, Maeda H, Bera TK, Pastan I. Palmitoylation of POTE family proteins for plasma membrane targeting. Biochemical and Biophysical Research Communications. 363: 751-6. PMID 17904529 DOI: 10.1016/j.bbrc.2007.09.045  0.44
2007 Powell DJ, Felipe-Silva A, Merino MJ, Ahmadzadeh M, Allen T, Levy C, White DE, Mavroukakis S, Kreitman RJ, Rosenberg SA, Pastan I. Administration of a CD25-directed immunotoxin, LMB-2, to patients with metastatic melanoma induces a selective partial reduction in regulatory T cells in vivo. Journal of Immunology (Baltimore, Md. : 1950). 179: 4919-28. PMID 17878392  0.44
2007 Steinbach D, Onda M, Voigt A, Dawczynski K, Wittig S, Hassan R, Gruhn B, Pastan I. Mesothelin, a possible target for immunotherapy, is expressed in primary AML cells. European Journal of Haematology. 79: 281-6. PMID 17803679 DOI: 10.1111/j.1600-0609.2007.00928.x  0.44
2007 Hassan R, Bullock S, Premkumar A, Kreitman RJ, Kindler H, Willingham MC, Pastan I. Phase I study of SS1P, a recombinant anti-mesothelin immunotoxin given as a bolus I.V. infusion to patients with mesothelin-expressing mesothelioma, ovarian, and pancreatic cancers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 5144-9. PMID 17785569 DOI: 10.1158/1078-0432.CCR-07-0869  0.44
2007 Sterman DH, Recio A, Carroll RG, Gillespie CT, Haas A, Vachani A, Kapoor V, Sun J, Hodinka R, Brown JL, Corbley MJ, Parr M, Ho M, Pastan I, Machuzak M, et al. A phase I clinical trial of single-dose intrapleural IFN-beta gene transfer for malignant pleural mesothelioma and metastatic pleural effusions: high rate of antitumor immune responses. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 4456-66. PMID 17671130 DOI: 10.1158/1078-0432.CCR-07-0403  0.44
2007 Du X, Ho M, Pastan I. New immunotoxins targeting CD123, a stem cell antigen on acute myeloid leukemia cells. Journal of Immunotherapy (Hagerstown, Md. : 1997). 30: 607-13. PMID 17667524 DOI: 10.1097/CJI.0b013e318053ed8e  0.44
2007 Sampson JH, Raghavan R, Brady ML, Provenzale JM, Herndon JE, Croteau D, Friedman AH, Reardon DA, Coleman RE, Wong T, Bigner DD, Pastan I, Rodríguez-Ponce MI, Tanner P, Puri R, et al. Clinical utility of a patient-specific algorithm for simulating intracerebral drug infusions. Neuro-Oncology. 9: 343-53. PMID 17435179 DOI: 10.1215/15228517-2007-007  0.44
2007 Yokokawa J, Bera TK, Palena C, Cereda V, Remondo C, Gulley JL, Arlen PM, Pastan I, Schlom J, Tsang KY. Identification of cytotoxic T-lymphocyte epitope(s) and its agonist epitope(s) of a novel target for vaccine therapy (PAGE4). International Journal of Cancer. Journal International Du Cancer. 121: 595-605. PMID 17397028 DOI: 10.1002/ijc.22698  0.44
2007 Filpula D, Yang K, Basu A, Hassan R, Xiang L, Zhang Z, Wang M, Wang QC, Ho M, Beers R, Zhao H, Peng P, Zhou J, Li X, Petti G, ... ... Pastan I, et al. Releasable PEGylation of mesothelin targeted immunotoxin SS1P achieves single dosage complete regression of a human carcinoma in mice. Bioconjugate Chemistry. 18: 773-84. PMID 17346030 DOI: 10.1021/bc060314x  0.44
2007 Ho M, Bera TK, Willingham MC, Onda M, Hassan R, FitzGerald D, Pastan I. Mesothelin expression in human lung cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 1571-5. PMID 17332303 DOI: 10.1158/1078-0432.CCR-06-2161  0.44
2007 Sampson JH, Raghavan R, Provenzale JM, Croteau D, Reardon DA, Coleman RE, Rodríguez Ponce I, Pastan I, Puri RK, Pedain C. Induction of hyperintense signal on T2-weighted MR images correlates with infusion distribution from intracerebral convection-enhanced delivery of a tumor-targeted cytotoxin. Ajr. American Journal of Roentgenology. 188: 703-9. PMID 17312057 DOI: 10.2214/AJR.06.0428  0.44
2007 Das S, Hahn Y, Nagata S, Willingham MC, Bera TK, Lee B, Pastan I. NGEP, a prostate-specific plasma membrane protein that promotes the association of LNCaP cells. Cancer Research. 67: 1594-601. PMID 17308099 DOI: 10.1158/0008-5472.CAN-06-2673  0.44
2007 Sampson JH, Brady ML, Petry NA, Croteau D, Friedman AH, Friedman HS, Wong T, Bigner DD, Pastan I, Puri RK, Pedain C. Intracerebral infusate distribution by convection-enhanced delivery in humans with malignant gliomas: descriptive effects of target anatomy and catheter positioning. Neurosurgery. 60: ONS89-98; discussion. PMID 17297371 DOI: 10.1227/01.NEU.0000249256.09289.5F  0.44
2007 Pastan I, Hassan R, FitzGerald DJ, Kreitman RJ. Immunotoxin treatment of cancer. Annual Review of Medicine. 58: 221-37. PMID 17059365 DOI: 10.1146/annurev.med.58.070605.115320  0.44
2007 Ise T, Nagata S, Kreitman RJ, Wilson WH, Wayne AS, Stetler-Stevenson M, Bishop MR, Scheinberg DA, Rassenti L, Kipps TJ, Kyle RA, Jelinek DF, Pastan I. Elevation of soluble CD307 (IRTA2/FcRH5) protein in the blood and expression on malignant cells of patients with multiple myeloma, chronic lymphocytic leukemia, and mantle cell lymphoma. Leukemia. 21: 169-74. PMID 17051241 DOI: 10.1038/sj.leu.2404445  0.44
2006 Onda M, Nagata S, FitzGerald DJ, Beers R, Fisher RJ, Vincent JJ, Lee B, Nakamura M, Hwang J, Kreitman RJ, Hassan R, Pastan I. Characterization of the B cell epitopes associated with a truncated form of Pseudomonas exotoxin (PE38) used to make immunotoxins for the treatment of cancer patients. Journal of Immunology (Baltimore, Md. : 1950). 177: 8822-34. PMID 17142785  0.44
2006 Lee Y, Ise T, Ha D, Saint Fleur A, Hahn Y, Liu XF, Nagata S, Lee B, Bera TK, Pastan I. Evolution and expression of chimeric POTE-actin genes in the human genome. Proceedings of the National Academy of Sciences of the United States of America. 103: 17885-90. PMID 17101985 DOI: 10.1073/pnas.0608344103  0.44
2006 Li Z, Mahesh SP, Shen de F, Liu B, Siu WO, Hwang FS, Wang QC, Chan CC, Pastan I, Nussenblatt RB. Eradication of tumor colonization and invasion by a B cell-specific immunotoxin in a murine model for human primary intraocular lymphoma. Cancer Research. 66: 10586-93. PMID 17079483 DOI: 10.1158/0008-5472.CAN-06-1981  0.68
2006 Kreitman RJ, Pastan I. Immunotoxins in the treatment of hematologic malignancies. Current Drug Targets. 7: 1301-11. PMID 17073592 DOI: 10.2174/138945006778559139  0.44
2006 Gubbels JA, Belisle J, Onda M, Rancourt C, Migneault M, Ho M, Bera TK, Connor J, Sathyanarayana BK, Lee B, Pastan I, Patankar MS. Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors. Molecular Cancer. 5: 50. PMID 17067392 DOI: 10.1186/1476-4598-5-50  0.44
2006 Kreitman RJ, Pastan I. BL22 and lymphoid malignancies. Best Practice & Research. Clinical Haematology. 19: 685-99. PMID 16997177 DOI: 10.1016/j.beha.2006.06.009  0.44
2006 Kreitman RJ, Pastan I. Immunotoxins in the treatment of refractory hairy cell leukemia. Hematology/Oncology Clinics of North America. 20: 1137-51, viii. PMID 16990113 DOI: 10.1016/j.hoc.2006.06.009  0.44
2006 Ho M, Onda M, Wang QC, Hassan R, Pastan I, Lively MO. Mesothelin is shed from tumor cells. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 15: 1751. PMID 16985043 DOI: 10.1158/1055-9965.EPI-06-0479  0.44
2006 Kennedy PE, Bera TK, Wang QC, Gallo M, Wagner W, Lewis MG, Berger EA, Pastan I. Anti-HIV-1 immunotoxin 3B3(Fv)-PE38: enhanced potency against clinical isolates in human PBMCs and macrophages, and negligible hepatotoxicity in macaques. Journal of Leukocyte Biology. 80: 1175-82. PMID 16923920 DOI: 10.1189/jlb.0306139  0.44
2006 Zhang Y, Xiang L, Hassan R, Paik CH, Carrasquillo JA, Jang BS, Le N, Ho M, Pastan I. Synergistic antitumor activity of taxol and immunotoxin SS1P in tumor-bearing mice. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 4695-701. PMID 16899620 DOI: 10.1158/1078-0432.CCR-06-0346  0.44
2006 Onda M, Nagata S, Ho M, Bera TK, Hassan R, Alexander RH, Pastan I. Megakaryocyte potentiation factor cleaved from mesothelin precursor is a useful tumor marker in the serum of patients with mesothelioma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 4225-31. PMID 16857795 DOI: 10.1158/1078-0432.CCR-06-0472  0.44
2006 Pastan I, Hassan R, Fitzgerald DJ, Kreitman RJ. Immunotoxin therapy of cancer. Nature Reviews. Cancer. 6: 559-65. PMID 16794638 DOI: 10.1038/nrc1891  0.44
2006 Ho M, Nagata S, Pastan I. Isolation of anti-CD22 Fv with high affinity by Fv display on human cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 9637-42. PMID 16763048 DOI: 10.1073/pnas.0603653103  0.44
2006 Ise T, Kreitman RJ, Pastan I, Nagata S. Sandwich ELISAs for soluble immunoglobulin superfamily receptor translocation-associated 2 (IRTA2)/FcRH5 (CD307) proteins in human sera. Clinical Chemistry and Laboratory Medicine : Cclm / Fescc. 44: 594-602. PMID 16681430 DOI: 10.1515/CCLM.2006.115  0.44
2006 Arons E, Margulies I, Sorbara L, Raffeld M, Stetler-Stevenson M, Pastan I, Kreitman RJ. Minimal residual disease in hairy cell leukemia patients assessed by clone-specific polymerase chain reaction. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 2804-11. PMID 16675574 DOI: 10.1158/1078-0432.CCR-05-2315  0.44
2006 Steinbach D, Schramm A, Eggert A, Onda M, Dawczynski K, Rump A, Pastan I, Wittig S, Pfaffendorf N, Voigt A, Zintl F, Gruhn B. Identification of a set of seven genes for the monitoring of minimal residual disease in pediatric acute myeloid leukemia. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 2434-41. PMID 16638849 DOI: 10.1158/1078-0432.CCR-05-2552  0.44
2006 Egland KA, Liu XF, Squires S, Nagata S, Man YG, Bera TK, Onda M, Vincent JJ, Strausberg RL, Lee B, Pastan I. High expression of a cytokeratin-associated protein in many cancers. Proceedings of the National Academy of Sciences of the United States of America. 103: 5929-34. PMID 16585525 DOI: 10.1073/pnas.0601296103  0.44
2006 Korherr C, Gille H, Schäfer R, Koenig-Hoffmann K, Dixelius J, Egland KA, Pastan I, Brinkmann U. Identification of proangiogenic genes and pathways by high-throughput functional genomics: TBK1 and the IRF3 pathway. Proceedings of the National Academy of Sciences of the United States of America. 103: 4240-5. PMID 16537515 DOI: 10.1073/pnas.0511319103  0.44
2006 Attia P, Powell DJ, Maker AV, Kreitman RJ, Pastan I, Rosenberg SA. Selective elimination of human regulatory T lymphocytes in vitro with the recombinant immunotoxin LMB-2. Journal of Immunotherapy (Hagerstown, Md. : 1997). 29: 208-14. PMID 16531821 DOI: 10.1097/01.cji.0000187959.45803.0c  0.44
2006 Hassan R, Remaley AT, Sampson ML, Zhang J, Cox DD, Pingpank J, Alexander R, Willingham M, Pastan I, Onda M. Detection and quantitation of serum mesothelin, a tumor marker for patients with mesothelioma and ovarian cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 447-53. PMID 16428485 DOI: 10.1158/1078-0432.CCR-05-1477  0.44
2006 Bera TK, Saint Fleur A, Lee Y, Kydd A, Hahn Y, Popescu NC, Zimonjic DB, Lee B, Pastan I. POTE paralogs are induced and differentially expressed in many cancers. Cancer Research. 66: 52-6. PMID 16397215 DOI: 10.1158/0008-5472.CAN-05-3014  0.44
2006 Hahn Y, Bera TK, Pastan IH, Lee B. Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains. Gene. 366: 238-45. PMID 16364570 DOI: 10.1016/j.gene.2005.07.045  0.44
2006 Arons E, Sorbara L, Raffeld M, Stetler-Stevenson M, Steinberg SM, Liewehr DJ, Pastan I, Kreitman RJ. Characterization of T-cell repertoire in hairy cell leukemia patients before and after recombinant immunotoxin BL22 therapy. Cancer Immunology, Immunotherapy : Cii. 55: 1100-10. PMID 16311729 DOI: 10.1007/s00262-005-0099-1  0.44
2005 Onda M, Willingham M, Nagata S, Bera TK, Beers R, Ho M, Hassan R, Kreitman RJ, Pastan I. New monoclonal antibodies to mesothelin useful for immunohistochemistry, fluorescence-activated cell sorting, Western blotting, and ELISA. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 5840-6. PMID 16115924 DOI: 10.1158/1078-0432.CCR-05-0578  0.44
2005 Hassan R, Kreitman RJ, Pastan I, Willingham MC. Localization of mesothelin in epithelial ovarian cancer. Applied Immunohistochemistry & Molecular Morphology : Aimm / Official Publication of the Society For Applied Immunohistochemistry. 13: 243-7. PMID 16082249 DOI: 10.1097/01.pai.00000141545.36485.d6  0.44
2005 Kreitman RJ, Squires DR, Stetler-Stevenson M, Noel P, FitzGerald DJ, Wilson WH, Pastan I. Phase I trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with B-cell malignancies. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 23: 6719-29. PMID 16061911 DOI: 10.1200/JCO.2005.11.437  0.44
2005 Sato N, Hassan R, Axworthy DB, Wong KJ, Yu S, Theodore LJ, Lin Y, Park L, Brechbiel MW, Pastan I, Paik CH, Carrasquillo JA. Pretargeted radioimmunotherapy of mesothelin-expressing cancer using a tetravalent single-chain Fv-streptavidin fusion protein. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 46: 1201-9. PMID 16000290  0.44
2005 Asano T, Niimura F, Pastan I, Fogo AB, Ichikawa I, Matsusaka T. Permanent genetic tagging of podocytes: fate of injured podocytes in a mouse model of glomerular sclerosis. Journal of the American Society of Nephrology : Jasn. 16: 2257-62. PMID 15987751 DOI: 10.1681/ASN.2004121134  0.44
2005 Ho M, Hassan R, Zhang J, Wang QC, Onda M, Bera T, Pastan I. Humoral immune response to mesothelin in mesothelioma and ovarian cancer patients. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 3814-20. PMID 15897581 DOI: 10.1158/1078-0432.CCR-04-2304  0.44
2005 Soler-García AA, Maitra R, Kumar V, Ise T, Nagata S, Beers R, Bera TK, Pastan I. The PATE gene is expressed in the accessory tissues of the human male genital tract and encodes a secreted sperm-associated protein. Reproduction (Cambridge, England). 129: 515-24. PMID 15798027 DOI: 10.1530/rep.1.00576  0.44
2005 Matsusaka T, Xin J, Niwa S, Kobayashi K, Akatsuka A, Hashizume H, Wang QC, Pastan I, Fogo AB, Ichikawa I. Genetic engineering of glomerular sclerosis in the mouse via control of onset and severity of podocyte-specific injury. Journal of the American Society of Nephrology : Jasn. 16: 1013-23. PMID 15758046 DOI: 10.1681/ASN.2004080720  0.44
2005 Bang S, Nagata S, Onda M, Kreitman RJ, Pastan I. HA22 (R490A) is a recombinant immunotoxin with increased antitumor activity without an increase in animal toxicity. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 1545-50. PMID 15746059 DOI: 10.1158/1078-0432.CCR-04-1939  0.44
2005 Sampson JH, Reardon DA, Friedman AH, Friedman HS, Coleman RE, McLendon RE, Pastan I, Bigner DD. Sustained radiographic and clinical response in patient with bifrontal recurrent glioblastoma multiforme with intracerebral infusion of the recombinant targeted toxin TP-38: case study. Neuro-Oncology. 7: 90-6. PMID 15701286 DOI: 10.1215/S1152851703000589  0.44
2005 Ise T, Maeda H, Santora K, Xiang L, Kreitman RJ, Pastan I, Nagata S. Immunoglobulin superfamily receptor translocation associated 2 protein on lymphoma cell lines and hairy cell leukemia cells detected by novel monoclonal antibodies. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 87-96. PMID 15671532  0.44
2005 Ho M, Kreitman RJ, Onda M, Pastan I. In vitro antibody evolution targeting germline hot spots to increase activity of an anti-CD22 immunotoxin. The Journal of Biological Chemistry. 280: 607-17. PMID 15491997 DOI: 10.1074/jbc.M409783200  0.44
2004 Hahn Y, Bera TK, Gehlhaus K, Kirsch IR, Pastan IH, Lee B. Finding fusion genes resulting from chromosome rearrangement by analyzing the expressed sequence databases. Proceedings of the National Academy of Sciences of the United States of America. 101: 13257-61. PMID 15326299 DOI: 10.1073/pnas.0405490101  0.44
2004 Bera TK, Huynh N, Maeda H, Sathyanarayana BK, Lee B, Pastan I. Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths. Gene. 337: 45-53. PMID 15276201 DOI: 10.1016/j.gene.2004.05.009  0.44
2004 Hassan R, Bera T, Pastan I. Mesothelin: a new target for immunotherapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 3937-42. PMID 15217923 DOI: 10.1158/1078-0432.CCR-03-0801  0.44
2004 Maeda H, Nagata S, Wolfgang CD, Bratthauer GL, Bera TK, Pastan I. The T cell receptor gamma chain alternate reading frame protein (TARP), a prostate-specific protein localized in mitochondria. The Journal of Biological Chemistry. 279: 24561-8. PMID 15150260 DOI: 10.1074/jbc.M402492200  0.44
2004 FitzGerald DJ, Kreitman R, Wilson W, Squires D, Pastan I. Recombinant immunotoxins for treating cancer. International Journal of Medical Microbiology : Ijmm. 293: 577-82. PMID 15149034 DOI: 10.1078/1438-4221-00302  0.44
2004 Oh S, Terabe M, Pendleton CD, Bhattacharyya A, Bera TK, Epel M, Reiter Y, Phillips J, Linehan WM, Kasten-Sportes C, Pastan I, Berzofsky JA. Human CTLs to wild-type and enhanced epitopes of a novel prostate and breast tumor-associated protein, TARP, lyse human breast cancer cells. Cancer Research. 64: 2610-8. PMID 15059918 DOI: 10.1158/0008-5472.CAN-03-2183  0.44
2004 Bera TK, Das S, Maeda H, Beers R, Wolfgang CD, Kumar V, Hahn Y, Lee B, Pastan I. NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate. Proceedings of the National Academy of Sciences of the United States of America. 101: 3059-64. PMID 14981236 DOI: 10.1073/pnas.0308746101  0.44
2004 Pastan I, Beers R, Bera TK. Recombinant immunotoxins in the treatment of cancer. Methods in Molecular Biology (Clifton, N.J.). 248: 503-18. PMID 14970517  0.44
2004 Decker T, Oelsner M, Kreitman RJ, Salvatore G, Wang QC, Pastan I, Peschel C, Licht T. Induction of caspase-dependent programmed cell death in B-cell chronic lymphocytic leukemia by anti-CD22 immunotoxins. Blood. 103: 2718-26. PMID 14525789 DOI: 10.1182/blood-2003-04-1317  0.44
2003 Bera TK, Hahn Y, Lee B, Pastan IH. TEPP, a new gene specifically expressed in testis, prostate, and placenta and well conserved in chordates. Biochemical and Biophysical Research Communications. 312: 1209-15. PMID 14652002 DOI: 10.1016/j.bbrc.2003.11.031  0.44
2003 Sampson JH, Akabani G, Archer GE, Bigner DD, Berger MS, Friedman AH, Friedman HS, Herndon JE, Kunwar S, Marcus S, McLendon RE, Paolino A, Penne K, Provenzale J, Quinn J, ... ... Pastan I, et al. Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malignant brain tumors. Journal of Neuro-Oncology. 65: 27-35. PMID 14649883 DOI: 10.1023/A:1026290315809  0.44
2003 Lelong-Rebel IH, Rebel G, Cardarelli CO, Pastan I, Gottesman MM. Modulation by the ATP/GTP ratio of the phosphorylation level of P-glycoprotein and of various plasma membrane proteins of KB-V1 multidrug resistant cells. Anticancer Research. 23: 2363-75. PMID 12894516  0.44
2003 Soda T, Nakashima R, Watanabe D, Nakajima K, Pastan I, Nakanishi S. Segregation and coactivation of developing neocortical layer 1 neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 6272-9. PMID 12867512  0.44
2003 Cheng WS, Giandomenico V, Pastan I, Essand M. Characterization of the androgen-regulated prostate-specific T cell receptor gamma-chain alternate reading frame protein (TARP) promoter. Endocrinology. 144: 3433-40. PMID 12865322 DOI: 10.1210/en.2003-0121  0.68
2003 Kitabatake Y, Hikida T, Watanabe D, Pastan I, Nakanishi S. Impairment of reward-related learning by cholinergic cell ablation in the striatum. Proceedings of the National Academy of Sciences of the United States of America. 100: 7965-70. PMID 12802017 DOI: 10.1073/pnas.1032899100  0.44
2003 Olsson P, Motegi A, Bera TK, Lee B, Pastan I. PRAC2: a new gene expressed in human prostate and prostate cancer. The Prostate. 56: 123-30. PMID 12746837 DOI: 10.1002/pros.10185  0.44
2003 Maitra R, Grigoryev DN, Bera TK, Pastan IH, Lee B. Cloning, molecular characterization, and expression analysis of Copine 8. Biochemical and Biophysical Research Communications. 303: 842-7. PMID 12670487 DOI: 10.1016/S0006-291X(03)00445-5  0.44
2003 Kreitman RJ, Pastan I. Immunobiological treatments of hairy-cell leukaemia. Best Practice & Research. Clinical Haematology. 16: 117-33. PMID 12670470 DOI: 10.1016/S1521-6926(03)00003-3  0.44
2003 Onda M, Vincent JJ, Lee B, Pastan I. Mutants of immunotoxin anti-Tac(dsFv)-PE38 with variable number of lysine residues as candidates for site-specific chemical modification. 1. Properties of mutant molecules. Bioconjugate Chemistry. 14: 480-7. PMID 12643760 DOI: 10.1021/bc020069r  0.44
2003 Egland KA, Vincent JJ, Strausberg R, Lee B, Pastan I. Discovery of the breast cancer gene BASE using a molecular approach to enrich for genes encoding membrane and secreted proteins. Proceedings of the National Academy of Sciences of the United States of America. 100: 1099-104. PMID 12538848 DOI: 10.1073/pnas.0337425100  0.44
2002 Hirano T, Watanabe D, Kawaguchi SY, Pastan I, Nakanishi S. Roles of inhibitory interneurons in the cerebellar cortex. Annals of the New York Academy of Sciences. 978: 405-12. PMID 12582069 DOI: 10.1111/j.1749-6632.2002.tb07583.x  0.44
2002 Iavarone C, Wolfgang C, Kumar V, Duray P, Willingham M, Pastan I, Bera TK. PAGE4 is a cytoplasmic protein that is expressed in normal prostate and in prostate cancers. Molecular Cancer Therapeutics. 1: 329-35. PMID 12489849  0.44
2002 Bera TK, Zimonjic DB, Popescu NC, Sathyanarayana BK, Kumar V, Lee B, Pastan I. POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. 99: 16975-80. PMID 12475935 DOI: 10.1073/pnas.262655399  0.44
2002 Pastan I, Kreitman RJ. Immunotoxins in cancer therapy. Current Opinion in Investigational Drugs (London, England : 2000). 3: 1089-91. PMID 12186272 DOI: 10.1016/S0952-7915(99)00005-9  0.44
2002 McHugh L, Hu S, Lee BK, Santora K, Kennedy PE, Berger EA, Pastan I, Hamer DH. Increased affinity and stability of an anti-HIV-1 envelope immunotoxin by structure-based mutagenesis. The Journal of Biological Chemistry. 277: 34383-90. PMID 12119300 DOI: 10.1074/jbc.M205456200  0.44
2002 Nagata S, Onda M, Numata Y, Santora K, Beers R, Kreitman RJ, Pastan I. Novel anti-CD30 recombinant immunotoxins containing disulfide-stabilized Fv fragments. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 8: 2345-55. PMID 12114439  0.44
2002 Bera TK, Iavarone C, Kumar V, Lee S, Lee B, Pastan I. MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 99: 6997-7002. PMID 12011458 DOI: 10.1073/pnas.102187299  0.44
2002 Hazama M, Watanabe D, Suzuki M, Mizoguchi A, Pastan I, Nakanishi S. Different regulatory sequences are required for parvalbumin gene expression in skeletal muscles and neuronal cells of transgenic mice. Brain Research. Molecular Brain Research. 100: 53-66. PMID 12008021 DOI: 10.1016/S0169-328X(02)00142-0  0.44
2002 Salvatore G, Beers R, Margulies I, Kreitman RJ, Pastan I. Improved cytotoxic activity toward cell lines and fresh leukemia cells of a mutant anti-CD22 immunotoxin obtained by antibody phage display. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 8: 995-1002. PMID 11948105  0.44
2002 Bera TK, Maitra R, Iavarone C, Salvatore G, Kumar V, Vincent JJ, Sathyanarayana BK, Duray P, Lee BK, Pastan I. PATE, a gene expressed in prostate cancer, normal prostate, and testis, identified by a functional genomic approach. Proceedings of the National Academy of Sciences of the United States of America. 99: 3058-63. PMID 11880645 DOI: 10.1073/pnas.052713699  0.44
2002 Joshi BH, Leland P, Silber J, Kreitman RJ, Pastan I, Berger M, Puri RK. IL-4 receptors on human medulloblastoma tumours serve as a sensitive target for a circular permuted IL-4-Pseudomonas exotoxin fusion protein. British Journal of Cancer. 86: 285-91. PMID 11870521 DOI: 10.1038/sj.bjc.6600034  0.44
2002 Decker T, Hipp S, Kreitman RJ, Pastan I, Peschel C, Licht T. Sensitization of B-cell chronic lymphocytic leukemia cells to recombinant immunotoxin by immunostimulatory phosphorothioate oligodeoxynucleotides. Blood. 99: 1320-6. PMID 11830482 DOI: 10.1182/blood.V99.4.1320  0.44
2001 Bera TK, Williams-Gould J, Beers R, Chowdhury P, Pastan I. Bivalent disulfide-stabilized fragment variable immunotoxin directed against mesotheliomas and ovarian cancer. Molecular Cancer Therapeutics. 1: 79-84. PMID 12467225  0.44
2001 Park JH, Kwon HW, Chung HK, Kim IH, Ahn K, Choi EJ, Pastan I, Choe M. A divalent recombinant immunotoxin formed by a disulfide bond between the extension peptide chains. Molecules and Cells. 12: 398-402. PMID 11804341  0.44
2001 Hikida T, Kaneko S, Isobe T, Kitabatake Y, Watanabe D, Pastan I, Nakanishi S. Increased sensitivity to cocaine by cholinergic cell ablation in nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America. 98: 13351-4. PMID 11606786 DOI: 10.1073/pnas.231488998  0.44
2001 Bera TK, Lee S, Salvatore G, Lee B, Pastan I. MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer. Molecular Medicine (Cambridge, Mass.). 7: 509-16. PMID 11591886  0.44
2001 Bera TK, Bera J, Brinkmann U, Tessarollo L, Pastan I. Cse1l is essential for early embryonic growth and development. Molecular and Cellular Biology. 21: 7020-4. PMID 11564884 DOI: 10.1128/MCB.21.20.7020-7024.2001  0.44
2001 Olsson P, Bera TK, Essand M, Kumar V, Duray P, Vincent J, Lee B, Pastan I. GDEP, a new gene differentially expressed in normal prostate and prostate cancer. The Prostate. 48: 231-41. PMID 11536302 DOI: 10.1002/pros.1102  0.44
2001 Kreitman RJ, Wilson WH, Bergeron K, Raggio M, Stetler-Stevenson M, FitzGerald DJ, Pastan I. Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia. The New England Journal of Medicine. 345: 241-7. PMID 11474661 DOI: 10.1056/NEJM200107263450402  0.44
2001 Onda M, Nagata S, Tsutsumi Y, Vincent JJ, Wang Q, Kreitman RJ, Lee B, Pastan I. Lowering the isoelectric point of the Fv portion of recombinant immunotoxins leads to decreased nonspecific animal toxicity without affecting antitumor activity. Cancer Research. 61: 5070-7. PMID 11431343  0.44
2001 Yoshida K, Watanabe D, Ishikane H, Tachibana M, Pastan I, Nakanishi S. A key role of starburst amacrine cells in originating retinal directional selectivity and optokinetic eye movement. Neuron. 30: 771-80. PMID 11430810 DOI: 10.1016/S0896-6273(01)00316-6  0.44
2001 Lee CG, Vieira WD, Pastan I, Gottesman MM. An episomally maintained MDR1 gene for gene therapy. Human Gene Therapy. 12: 945-53. PMID 11387059 DOI: 10.1089/104303401750195908  0.4
2001 Rozemuller H, Chowdhury PS, Pastan I, Kreitman RJ. Isolation of new anti-CD30 scFvs from DNA-immunized mice by phage display and biologic activity of recombinant immunotoxins produced by fusion with truncated pseudomonas exotoxin. International Journal of Cancer. Journal International Du Cancer. 92: 861-70. PMID 11351308 DOI: 10.1002/ijc.1266  0.44
2001 Liu XF, Olsson P, Wolfgang CD, Bera TK, Duray P, Lee B, Pastan I. PRAC: A novel small nuclear protein that is specifically expressed in human prostate and colon. The Prostate. 47: 125-31. PMID 11340635 DOI: 10.1002/pros.1055  0.44
2001 Yerushalmi N, Keppler-Hafkemeyer A, Vasmatzis G, Liu XF, Olsson P, Bera TK, Duray P, Lee B, Pastan I. ERGL, a novel gene related to ERGIC-53 that is highly expressed in normal and neoplastic prostate and several other tissues. Gene. 265: 55-60. PMID 11255007 DOI: 10.1016/S0378-1119(01)00347-X  0.44
2000 Onda M, Willingham M, Wang QC, Kreitman RJ, Tsutsumi Y, Nagata S, Pastan I. Inhibition of TNF-alpha produced by Kupffer cells protects against the nonspecific liver toxicity of immunotoxin anti-Tac(Fv)-PE38, LMB-2. Journal of Immunology (Baltimore, Md. : 1950). 165: 7150-6. PMID 11120846  0.44
2000 Liu XF, Helman LJ, Yeung C, Bera TK, Lee B, Pastan I. XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma. Cancer Research. 60: 4752-5. PMID 10987281  0.44
2000 Leland P, Taguchi J, Husain SR, Kreitman RJ, Pastan I, Puri RK. Human breast carcinoma cells express type II IL-4 receptors and are sensitive to antitumor activity of a chimeric IL-4-Pseudomonas exotoxin fusion protein in vitro and in vivo. Molecular Medicine (Cambridge, Mass.). 6: 165-78. PMID 10965493  0.44
2000 Wolfgang CD, Essand M, Vincent JJ, Lee B, Pastan I. TARP: a nuclear protein expressed in prostate and breast cancer cells derived from an alternate reading frame of the T cell receptor gamma chain locus. Proceedings of the National Academy of Sciences of the United States of America. 97: 9437-42. PMID 10931945 DOI: 10.1073/pnas.160270597  0.44
2000 Hassan R, Viner JL, Wang QC, Margulies I, Kreitman RJ, Pastan I. Anti-tumor activity of K1-LysPE38QQR, an immunotoxin targeting mesothelin, a cell-surface antigen overexpressed in ovarian cancer and malignant mesothelioma. Journal of Immunotherapy (Hagerstown, Md. : 1997). 23: 473-9. PMID 10916757 DOI: 10.1097/00002371-200007000-00011  0.44
2000 Kaneko S, Hikida T, Watanabe D, Ichinose H, Nagatsu T, Kreitman RJ, Pastan I, Nakanishi S. Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function. Science (New York, N.Y.). 289: 633-7. PMID 10915629 DOI: 10.1126/science.289.5479.633  0.44
2000 Tsutsumi Y, Onda M, Nagata S, Lee B, Kreitman RJ, Pastan I. Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity. Proceedings of the National Academy of Sciences of the United States of America. 97: 8548-53. PMID 10890891 DOI: 10.1073/pnas.140210597  0.44
2000 Rand RW, Kreitman RJ, Patronas N, Varricchio F, Pastan I, Puri RK. Intratumoral administration of recombinant circularly permuted interleukin-4-Pseudomonas exotoxin in patients with high-grade glioma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 6: 2157-65. PMID 10873064  0.44
2000 Keppler-Hafkemeyer A, Kreitman RJ, Pastan I. Apoptosis induced by immunotoxins used in the treatment of hematologic malignancies. International Journal of Cancer. Journal International Du Cancer. 87: 86-94. PMID 10861457 DOI: 10.1002/1097-0215(20000701)87:1<86::AID-IJC13>3.0.CO;2-I  0.44
2000 Booth CL, Pulaski L, Gottesman MM, Pastan I. Analysis of the properties of the N-terminal nucleotide-binding domain of human P-glycoprotein. Biochemistry. 39: 5518-26. PMID 10820025 DOI: 10.1021/bi992931x  0.44
2000 Pai-Scherf LH, Carrasquillo JA, Paik C, Gansow O, Whatley M, Pearson D, Webber K, Hamilton M, Allegra C, Brechbiel M, Willingham MC, Pastan I. Imaging and phase I study of 111In- and 90Y-labeled anti-LewisY monoclonal antibody B3. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 6: 1720-30. PMID 10815890  0.44
2000 Kreitman RJ, Margulies I, Stetler-Stevenson M, Wang QC, FitzGerald DJ, Pastan I. Cytotoxic activity of disulfide-stabilized recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) toward fresh malignant cells from patients with B-cell leukemias. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 6: 1476-87. PMID 10778980  0.44
2000 Kobayashi H, Kao CH, Kreitman RJ, Le N, Kim MK, Brechbiel MW, Paik CH, Pastan I, Carrasquillo JA. Pharmacokinetics of 111In- and 125I-labeled antiTac single-chain Fv recombinant immunotoxin. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 41: 755-62. PMID 10768579  0.44
2000 Kreitman RJ, Wilson WH, White JD, Stetler-Stevenson M, Jaffe ES, Giardina S, Waldmann TA, Pastan I. Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 18: 1622-36. PMID 10764422  0.44
2000 Bera TK, Pastan I. Mesothelin is not required for normal mouse development or reproduction. Molecular and Cellular Biology. 20: 2902-6. PMID 10733593 DOI: 10.1128/MCB.20.8.2902-2906.2000  0.44
2000 Hafkemeyer P, Licht T, Pastan I, Gottesman MM. Chemoprotection of hematopoietic cells by a mutant P-glycoprotein resistant to a potent chemosensitizer of multidrug-resistant cancers. Human Gene Therapy. 11: 555-65. PMID 10724034 DOI: 10.1089/10430340050015743  0.4
2000 Goldstein H, Pettoello-Mantovani M, Bera TK, Pastan IH, Berger EA. Chimeric toxins targeted to the human immunodeficiency virus type 1 envelope glycoprotein augment the in vivo activity of combination antiretroviral therapy in thy/liv-SCID-Hu mice. The Journal of Infectious Diseases. 181: 921-6. PMID 10720513 DOI: 10.1086/315351  0.44
2000 Shen DW, Goldenberg S, Pastan I, Gottesman MM. Decreased accumulation of [14C]carboplatin in human cisplatin-resistant cells results from reduced energy-dependent uptake. Journal of Cellular Physiology. 183: 108-16. PMID 10699972 DOI: 10.1002/(SICI)1097-4652(200004)183:1<108::AID-JCP13>3.0.CO;2-4  0.4
2000 Lee CG, Ramachandra M, Jeang KT, Martin MA, Pastan I, Gottesman MM. Effect of ABC transporters on HIV-1 infection: inhibition of virus production by the MDR1 transporter. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 14: 516-22. PMID 10698967  0.4
2000 Licht T, Goldenberg SK, Vieira WD, Gottesman MM, Pastan I. Drug selection of MDR1-transduced hematopoietic cells ex vivo increases transgene expression and chemoresistance in reconstituted bone marrow in mice. Gene Therapy. 7: 348-58. PMID 10694816 DOI: 10.1038/sj.gt.3301087  0.4
1999 Onda M, Kreitman RJ, Vasmatzis G, Lee B, Pastan I. Reduction of the nonspecific animal toxicity of anti-Tac(Fv)-PE38 by mutations in the framework regions of the Fv which lower the isoelectric point. Journal of Immunology (Baltimore, Md. : 1950). 163: 6072-7. PMID 10570296  0.44
1999 Kreitman RJ, Wilson WH, Robbins D, Margulies I, Stetler-Stevenson M, Waldmann TA, Pastan I. Responses in refractory hairy cell leukemia to a recombinant immunotoxin. Blood. 94: 3340-8. PMID 10552943  0.44
1999 Zhou Y, Gottesman MM, Pastan I. Domain exchangeability between the multidrug transporter (MDR1) and phosphatidylcholine flippase (MDR2). Molecular Pharmacology. 56: 997-1004. PMID 10531406  0.4
1998 Bera TK, Kennedy PE, Berger EA, Barbas CF, Pastan I. Specific killing of HIV-infected lymphocytes by a recombinant immunotoxin directed against the HIV-1 envelope glycoprotein. Molecular Medicine (Cambridge, Mass.). 4: 384-91. PMID 10780881  0.44
1986 Hanover JA, D'Souza P, August T, Pastan I, Willingham MC. Monoclonal antibodies against a glycoprotein localized in coated pits and endocytic vesicles inhibit α2-macroglobulin binding and uptake Journal of Biological Chemistry. 261: 16732-16737. PMID 2430970  0.68
1985 Hanover JA, Pastan I, Willingham MC. Inhibition of phosphatidylcholine synthesis does not alter uptake of transferrin by LM fibroblasts Experimental Cell Research. 157: 276-281. PMID 3972013 DOI: 10.1016/0014-4827(85)90170-3  0.68
1985 Akiyama Si, Fojo A, Hanover JA, Pastan I, Gottesman MM. Isolation and genetic characterization of human KB cell lines resistant to multiple drugs Somatic Cell and Molecular Genetics. 11: 117-126. PMID 3856953 DOI: 10.1007/BF01534700  0.68
1985 Hanover JA, Beguinot L, Willingham MC, Pastan IH. Transit of receptors for epidermal growth factor and transferrin through clathrin-coated pits. Analysis of the kinetics of receptor entry Journal of Biological Chemistry. 260: 15938-15945. PMID 2866188  0.68
1985 Beguinot L, Hanover JA, Ito S, Richert ND, Willingham MC, Pastan I. Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors Proceedings of the National Academy of Sciences of the United States of America. 82: 2774-2778. PMID 2859591 DOI: 10.1073/pnas.82.9.2774  0.68
1985 Dickson RB, Hanover JA, Pastan I, Willingham MC. Isolation of receptosomes (endosomes) from human KB cells Methods in Enzymology. 257-271. PMID 2859514  0.44
1984 Hanover JA, Willingham MC, Pastan I. Kinetics of transit of transferrin and epidermal growth factor through clathrin-coated membranes Cell. 39: 283-293. PMID 6149810 DOI: 10.1016/0092-8674(84)90006-0  0.68
1984 Willingham MC, Strader CD, Lefkowitz RJ, Pastan I. Morphologic demonstration of clathrin-coated pits in frog and turkey erythrocytes. Experimental Cell Research. 151: 573-7. PMID 6142826  1
1984 Willingham MC, Hanover JA, Dickson RB, Pastan I. Morphologic characterization of the pathway of transferrin endocytosis and recycling in human KB cells Proceedings of the National Academy of Sciences of the United States of America. 81: 175-179. PMID 6141558  0.68
1984 Akiyama S, Gottesman MM, Hanover JA, Fitzgerald DJ, Willingham MC, Pastan I. Verapamil enhances the toxicity of conjugates of epidermal growth factor with Pseudomonas exotoxin and antitransferrin receptor with Pseudomonas exotoxin Journal of Cellular Physiology. 120: 271-279. PMID 6086678  0.68
1983 Hanover JA, Rudick JE, Willingham MC, Pastan I. α2-macroglobulin binding to cultured fibroblasts: Identification by affinity chromatography of high-affinity binding sites Archives of Biochemistry and Biophysics. 227: 570-579. PMID 6667030 DOI: 10.1016/0003-9861(83)90486-1  0.68
1983 Dickson RB, Hanover JA, Willingham MC, Pastan I. Prelysosomal divergence of transferrin and epidermal growth factor during receptor-mediated endocytosis Biochemistry. 22: 5667-5674. PMID 6317024  0.68
1983 Dickson RB, Beguinot L, Hanover JA, Richert ND, Willingham MC, Pastan I. Isolation and characterization of a highly enriched preparation of receptosomes (endosomes) from a human cell line Proceedings of the National Academy of Sciences of the United States of America. 80: 5335-5339. PMID 6310570  0.68
1983 Hanover JA, Willingham MC, Pastan I. Receptor-mediated endocytosis of α2-macroglobulin: Solubilization and partial purification of the fibroblast α2-macroglobulin receptor Annals of the New York Academy of Sciences. 410-423. PMID 6202215  0.68
1983 Hanover JA, Cheng S, Willingham MC, Pastan IH. α2-Macroglobulin binding to cultured fibroblasts. Solubilization and partial purification of binding sites Journal of Biological Chemistry. 258: 370-377. PMID 6184373  0.68
1981 Maxfield FR, Willingham MC, Pastan I, Dragsten P, Cheng SY. Binding and mobility of the cell surface receptors for 3,3',5-triiodo-L-thyronine. Science (New York, N.Y.). 211: 63-5. PMID 6255563  0.68
1981 Maxfield FR, Willingham MC, Haigler HT, Dragsten P, Pastan IH. Binding, surface mobility, internalization, and degradation of rhodamine-labeled alpha 2-macroglobulin. Biochemistry. 20: 5353-8. PMID 6170323  0.68
1980 Haigler HT, Maxfield FR, Willingham MC, Pastan I. Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells. The Journal of Biological Chemistry. 255: 1239-41. PMID 6243633  0.68
1980 Willingham MC, Maxfield FR, Pastan I. Receptor-mediated endocytosis of alpha 2-macroglobulin in cultured fibroblasts. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 28: 818-23. PMID 6160180  0.56
1980 Cheng SY, Maxfield FR, Robbins J, Willingham MC, Pastan IH. Receptor-mediated uptake of 3,3',5-triiodo-L-thyronine by cultured fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 77: 3425-9. PMID 6158047  0.56
1980 Davies PJ, Davies DR, Levitzki A, Maxfield FR, Milhaud P, Willingham MC, Pastan IH. Transglutaminase is essential in receptor-mediated endocytosis of alpha 2-macroglobulin and polypeptide hormones. Nature. 283: 162-7. PMID 6153122  0.56
1979 Willingham MC, Maxfield FR, Pastan IH. alpha 2 Macroglobulin binding to the plasma membrane of cultured fibroblasts. Diffuse binding followed by clustering in coated regions. The Journal of Cell Biology. 82: 614-25. PMID 92473  0.56
1979 Maxfield FR, Willingham MC, Davies PJ, Pastan I. Amines inhibit the clustering of alpha2-macroglobulin and EGF on the fibroblast cell surface. Nature. 277: 661-3. PMID 85262  0.56
1979 Maxfield FR, Davies PJ, Klempner L, Willingham MC, Pastan I. Epidermal growth factor stimulation of DNA synthesis is potentiated by compounds that inhibit its clustering in coated pits. Proceedings of the National Academy of Sciences of the United States of America. 76: 5731-5. PMID 42903  0.56
1978 Maxfield FR, Schlessinger J, Shechter Y, Pastan I, Willingham MC. Collection of insulin, EGF and alpha2-macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization. Cell. 14: 805-10. PMID 80283 DOI: 10.1016/0092-8674(78)90336-7  0.68
1972 Stadtman ER, Stadtman TC, Pastan I, Smith LD. Clostridium barkeri sp. n. Journal of Bacteriology. 110: 758-60. PMID 4553843  0.68
1971 Pastan I, Perlman RL, Emmer M, Varmus HE, DeCrombrugghe B, Chen BP, Parks J. Regulation of gene expression in Escherichia coli by cyclic AMP. Recent Progress in Hormone Research. 27: 421-32. PMID 4336400  0.68
1971 Lefkowitz RJ, Roth J, Pastan I. ACTH-receptor interaction in the adrenal: a model for the initial step in the action of hormones that stimulate adenyl cyclase. Annals of the New York Academy of Sciences. 185: 195-209. PMID 4330491  1
1971 Miller Z, Varmus HE, Parks JS, Perlman RL, Pastan I. Regulation of gal messenger ribonucleic acid synthesis in Escherichia coli by 3',5'-cyclic adenosine monophosphate. The Journal of Biological Chemistry. 246: 2898-903. PMID 4324343  0.68
1971 Varmus HE, Perlman RL, Pastan I. Regulation of lac transcription in antibiotic-treated E. coli. Nature: New Biology. 230: 41-4. PMID 4324113  0.68
1971 De Crombrugghe B, Chen B, Gottesman M, Pastan I, Varmus HE, Emmer M, Perlman RL. Regulation of lac mRNA synthesis in a soluble cell-free system. Nature: New Biology. 230: 37-40. PMID 4324112  0.68
1970 Varmus HE, Perlman RL, Pastan I. Regulation of lac transcription in Escherichia coli by cyclic adenosine 3',5'-monophosphate. Studies with deoxyribonucleic acid-ribonucleic acid hybridization and hybridization competition. The Journal of Biological Chemistry. 245: 6366-72. PMID 4320837  0.68
1970 Lefkowitz RJ, Roth J, Pastan I. Effects of calcium on ACTH stimulation of the adrenal: separation of hormone binding from adenyl cyclase activation. Nature. 228: 864-6. PMID 4320054  1
1970 Lefkowitz RJ, Roth J, Pastan I. Radioreceptor assay of adrenocorticotropic hormone: new approach to assay of polypeptide hormones in plasma. Science (New York, N.Y.). 170: 633-5. PMID 4319388  1
1970 Lefkowitz RJ, Roth J, Pricer W, Pastan I. ACTH receptors in the adrenal: specific binding of ACTH-125I and its relation to adenyl cyclase. Proceedings of the National Academy of Sciences of the United States of America. 65: 745-52. PMID 4315615  1
1970 Varmus HE, Perlman RL, Pastan I. Regulation of lac messenger ribonucleic acid synthesis by cyclic adenosine 3',5'-monophosphate and glucose. The Journal of Biological Chemistry. 245: 2259-67. PMID 4315149  0.68
1970 de Crombrugghe B, Varmus HE, Perlman RL, Pastan IH. Stimulation of lac mRNA synthesis by cyclic AMP in cell free extracts of Escherichia coli. Biochemical and Biophysical Research Communications. 38: 894-901. PMID 4314384 DOI: 10.1016/0006-291X(70)90805-3  0.68
1969 De Crombrugghe B, Perlman RL, Varmus HE, Pastan I. Regulation of inducible enzyme synthesis in Escherichia coli by cyclic adenosine 3', 5'-monophosphate. The Journal of Biological Chemistry. 244: 5828-35. PMID 4310825  0.68
1966 Tsai L, Pastan I, Stadtman ER. Nicotinic acid metabolism. II. The isolation and characterization of intermediates in the fermentation of nicotinic acid. The Journal of Biological Chemistry. 241: 1807-13. PMID 5945854  0.6
1964 PASTAN I, TSAI L, STADTMAN ER. NICOTINIC ACID METABOLISM. I. DISTRIBUTION OF ISOTOPE IN FERMENTATION PRODUCTS OF LABELLED NICOTINIC ACID. The Journal of Biological Chemistry. 239: 902-6. PMID 14157025  0.6
Show low-probability matches.