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Ira Pastan - Publications

Affiliations: 
National Institutes of Health, Bethesda, MD 
Area:
Molecular Biology
Website:
http://ccr.nci.nih.gov/staff/staff.asp?profileid=5782
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Year Citation  Score
2020 Mazor R, Pastan I. Immunogenicity of Immunotoxins Containing Exotoxin A: Causes, Consequences, and Mitigation. Frontiers in Immunology. 11: 1261. PMID 32695104 DOI: 10.3389/fimmu.2020.01261  0.361
2020 Inoue S, Tsunoda T, Riku M, Ito H, Inoko A, Murakami H, Ebi M, Ogasawara N, Pastan I, Kasugai K, Kasai K, Ikeda H, Inaguma S. Diffuse mesothelin expression leads to worse prognosis through enhanced cellular proliferation in colorectal cancer. Oncology Letters. 19: 1741-1750. PMID 32194667 DOI: 10.3892/ol.2020.11290  0.311
2020 Liu XF, Wei J, Zhou Q, Molitoris BA, Sandoval R, Kobayashi H, Okada R, Nagaya T, Karim B, Butcher D, Pastan I. Immunotoxin SS1P is rapidly removed by proximal tubule cells of kidney, whose damage contributes to albumin loss in urine. Proceedings of the National Academy of Sciences of the United States of America. PMID 32123080 DOI: 10.1073/pnas.1919038117  0.322
2019 Zheng Z, Okada R, Kobayashi H, Nagaya T, Wei J, Zhou Q, Lee F, Bera TK, Gao Y, Kuhlman W, Tai CH, Pastan I. Site-specific PEGylation of anti-mesothelin recombinant immunotoxins increases half-life and anti-tumor activity. Molecular Cancer Therapeutics. PMID 31871266 DOI: 10.1158/1535-7163.MCT-19-0890  0.313
2019 Fleming BD, Urban DJ, Hall M, Longerich T, Greten T, Pastan I, Ho M. The engineered anti-GPC3 immunotoxin, HN3-ABD-T20, produces regression in mouse liver cancer xenografts via prolonged serum retention. Hepatology (Baltimore, Md.). PMID 31520528 DOI: 10.1002/Hep.30949  0.309
2019 Cerise A, Bera TK, Liu X, Wei J, Pastan I. Anti-Mesothelin Recombinant Immunotoxin Therapy for Colorectal Cancer. Clinical Colorectal Cancer. PMID 31345777 DOI: 10.1016/j.clcc.2019.06.006  0.309
2019 Bera TK, Liu W, Leshem J, King E, Kozlov S, Pastan I. Generation of a Transgenic BALB/c Mouse Line With Selective Expression of Human Mesothelin in Thyroid Gland: Application in Mesothelin-targeted Immunotherapy. Journal of Immunotherapy (Hagerstown, Md. : 1997). PMID 30933045 DOI: 10.1097/CJI.0000000000000263  0.343
2019 Leshem Y, Pastan I. Exotoxin Immunotoxins and Anti-Tumor Immunity: From Observations at the Patient's Bedside to Evaluation in Preclinical Models. Toxins. 11. PMID 30621280 DOI: 10.3390/toxins11010020  0.306
2019 Kreitman R, Gorelik D, Stetler-Stevenson M, Yuan CM, Wang H, Zhou H, Potocka K, Fykes E, Arons E, Pastan I. Abstract CN07-03: Recombinant immunotoxins for hematologic malignancies Molecular Cancer Therapeutics. 18. DOI: 10.1158/1535-7163.Targ-19-Cn07-03  0.338
2019 Ho M, Fleming BD, Greten TF, Pastan I. Abstract CN07-02: Immunotoxins targeting GPC3 for liver cancer Molecular Cancer Therapeutics. 18. DOI: 10.1158/1535-7163.Targ-19-Cn07-02  0.313
2018 Mazor R, King EM, Pastan I. Strategies to reduce the immunogenicity of recombinant immunotoxins. The American Journal of Pathology. PMID 29870741 DOI: 10.1016/j.ajpath.2018.04.016  0.332
2018 Kaplan G, Mazor R, Lee F, Jang Y, Leshem Y, Pastan I. Improving the in vivo efficacy of an anti-Tac (CD25) immunotoxin by Pseudomonas exotoxin A domain II engineering. Molecular Cancer Therapeutics. PMID 29695631 DOI: 10.1158/1535-7163.MCT-17-1041  0.322
2018 Wei J, Bera TK, Liu XF, Zhou Q, Onda M, Ho M, Tai CH, Pastan I. Recombinant immunotoxins with albumin-binding domains have long half-lives and high antitumor activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 29581296 DOI: 10.1073/pnas.1721780115  0.373
2018 Müller F, Cunningham T, Stookey S, Tai CH, Burkett S, Jailwala P, Stetler Stevenson M, Cam MC, Wayne AS, Pastan I. 5-Azacytidine prevents relapse and produces long-term complete remissions in leukemia xenografts treated with Moxetumomab pasudotox. Proceedings of the National Academy of Sciences of the United States of America. PMID 29432154 DOI: 10.1073/pnas.1714512115  0.348
2018 Mazor R, King EM, Onda M, Cuburu N, Addissie S, Crown D, Liu XF, Kishimoto TK, Pastan I. Tolerogenic nanoparticles restore the antitumor activity of recombinant immunotoxins by mitigating immunogenicity. Proceedings of the National Academy of Sciences of the United States of America. PMID 29311317 DOI: 10.1073/pnas.1717063115  0.307
2017 Liu XF, Zhou Q, Hassan R, Pastan I. Panbinostat decreases cFLIP and enhances killing of cancer cells by immunotoxin LMB-100 by stimulating the extrinsic apoptotic pathway. Oncotarget. 8: 87307-87316. PMID 29152082 DOI: 10.18632/oncotarget.20263  0.341
2017 Bera TK, Abe Y, Ise T, Oberle A, Gallardo D, Liu XF, Nagata S, Binder M, Pastan I. Recombinant immunotoxins targeting B-cell maturation antigen are cytotoxic to myeloma cell lines and myeloma cells from patients. Leukemia. PMID 29149102 DOI: 10.1038/leu.2017.315  0.338
2017 Leshem Y, O'Brien J, Liu X, Bera TK, Terabe M, Berzofsky JA, Bossenmaier B, Niederfellner G, Tai CH, Reiter Y, Pastan I. Combining Local Immunotoxins Targeting Mesothelin with CTLA-4 Blockade Synergistically Eradicates Murine Cancer by Promoting Anti-Cancer Immunity. Cancer Immunology Research. PMID 28674083 DOI: 10.1158/2326-6066.CIR-16-0330  0.309
2017 Inaguma S, Wang Z, Lasota J, Onda M, Czapiewski P, Langfort R, Rys J, Szpor J, Waloszczyk P, Okoń K, Biernat W, Ikeda H, Schrump DS, Hassan R, Pastan I, et al. Comprehensive immunohistochemical study of mesothelin (MSLN) using different monoclonal antibodies 5B2 and MN-1 in 1562 tumors with evaluation of its prognostic value in malignant pleural mesothelioma. Oncotarget. 8: 26744-26754. PMID 28460459 DOI: 10.18632/oncotarget.15814  0.311
2017 Müller F, Stookey S, Cunningham T, Pastan I. Paclitaxel synergizes with exposure time adjusted CD22-targeting immunotoxins against B-cell malignancies. Oncotarget. PMID 28423727 DOI: 10.18632/oncotarget.16141  0.337
2017 Mazor R, Kaplan G, Park D, Jang Y, Lee F, Kreitman R, Pastan I. Rational design of low immunogenic anti CD25 recombinant immunotoxin for T cell malignancies by elimination of T cell epitopes in PE38. Cellular Immunology. PMID 28087047 DOI: 10.1016/j.cellimm.2017.01.003  0.332
2017 Yu X, Keir ST, Szafranski S, Clayton S, Pastan I, Bigner DD, Chandramohan V. Immunotoxin and bcl-2 inhibitor combination therapy targeting chondroitin sulfate proteoglycan 4. Journal of Clinical Oncology. 35: 74-74. DOI: 10.1200/Jco.2017.35.7_Suppl.74  0.368
2016 Bao X, Pastan I, Bigner DD, Chandramohan V. EGFR/EGFRvIII-targeted immunotoxin therapy for the treatment of glioblastomas via convection-enhanced delivery. Receptors & Clinical Investigation. 3. PMID 28286803 DOI: 10.14800/Rci.1430  0.306
2016 Hassan R, Thomas A, Alewine C, Le DT, Jaffee EM, Pastan I. Mesothelin Immunotherapy for Cancer: Ready for Prime Time? Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 34: 4171-4179. PMID 27863199 DOI: 10.1200/Jco.2016.68.3672  0.334
2016 Mazor R, Addissie S, Jang Y, Tai CH, Rose J, Hakim F, Pastan I. Role of HLA-DP in the Presentation of Epitopes from the Truncated Bacterial PE38 Immunotoxin. The Aaps Journal. PMID 27796910 DOI: 10.1208/s12248-016-9986-y  0.303
2016 Liu XF, Xiang L, Zhou Q, Carralot JP, Prunotto M, Niederfellner G, Pastan I. Actinomycin D enhances killing of cancer cells by immunotoxin RG7787 through activation of the extrinsic pathway of apoptosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 27601652 DOI: 10.1073/pnas.1611481113  0.321
2016 Antignani A, Mathews Griner L, Guha R, Simon N, Pasetto M, Keller J, Huang M, Angelus E, Pastan I, Ferrer M, FitzGerald DJ, Thomas CJ. Chemical Screens Identify Drugs that Enhance or Mitigate Cellular Responses to Antibody-Toxin Fusion Proteins. Plos One. 11: e0161415. PMID 27556570 DOI: 10.1371/Journal.Pone.0161415  0.344
2016 Bauss F, Lechmann M, Krippendorff BF, Staack R, Herting F, Festag M, Imhof-Jung S, Hesse F, Pompiati M, Kollmorgen G, da Silva Mateus Seidl R, Bossenmaier B, Lau W, Schantz C, Stracke JO, ... ... Pastan I, et al. Characterization of a re-engineered, mesothelin-targeted Pseudomonas exotoxin fusion protein for lung cancer therapy. Molecular Oncology. PMID 27507537 DOI: 10.1016/j.molonc.2016.07.003  0.326
2016 Kaplan G, Lee F, Onda M, Kolyvas E, Bhardwaj G, Baker D, Pastan I. Protection of the Furin Cleavage Site in Low-Toxicity Immunotoxins Based on Pseudomonas Exotoxin A. Toxins. 8. PMID 27463727 DOI: 10.3390/Toxins8080217  0.306
2016 Awuah P, Bera TK, Folivi M, Chertov O, Pastan I. Reduced Shedding of Surface Mesothelin Improves Efficacy of Mesothelin Targeting Recombinant Immunotoxins. Molecular Cancer Therapeutics. PMID 27196771 DOI: 10.1158/1535-7163.MCT-15-0863  0.346
2016 Mazor R, Onda M, Park D, Addissie S, Xiang L, Zhang J, Hassan R, Pastan I. Dual B- and T-cell de-immunization of recombinant immunotoxin targeting mesothelin with high cytotoxic activity. Oncotarget. PMID 27167198 DOI: 10.18632/oncotarget.9171  0.354
2016 Liu X, Mueller F, Wayne AS, Pastan I. Protein kinase inhibitor H89 enhances the activity of Pseudomonas exotoxin A-based immunotoxins. Molecular Cancer Therapeutics. PMID 26939705 DOI: 10.1158/1535-7163.MCT-15-0828  0.32
2016 Mazor R, Onda M, Pastan I. Immunogenicity of therapeutic recombinant immunotoxins. Immunological Reviews. 270: 152-64. PMID 26864110 DOI: 10.1111/imr.12390  0.334
2016 Antignani A, Mathews-Griner L, Ferrer M, Simon N, Angelus E, Huang M, Pastan I, Thomas C, FitzGerald DJ. Abstract A67: The mTOR inhibitor, everolimus, enhances the cytotoxicity of pseudomonas-based immunotoxins: Mechanistic insights Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Metca15-A67  0.325
2016 Alewine C, Landsman R, Rudloff M, Kolyvas E, Chen J, Pastan I. Abstract B37: Mesothelin-targeted immunotoxin RG7787 (LMB-100) preferentially depletes secreted proteins and short-lived intracellular proteins to augment tumor cell killing by taxanes Cancer Research. 76. DOI: 10.1158/1538-7445.Panca16-B37  0.331
2016 Ali-Rahmani F, Fitzgerald D, Martin S, Patel P, Prunotto M, Ormanoglu P, Thomas C, Pastan I. Abstract 743: Tyrosine kinase discoidin domain receptor-1 (DDR1) regulates cytotoxicity of recombinant immunotoxin for cancer therapy Cancer Research. 76: 743-743. DOI: 10.1158/1538-7445.Am2016-743  0.328
2016 Liu XF, Xiang L, Prunotto M, Niederfellner G, Pastan I. Abstract 1290: Actinomycin D enhanced immunotoxin RG7787 killing of cancer cells Cancer Research. 76: 1290-1290. DOI: 10.1158/1538-7445.Am2016-1290  0.327
2015 Ali-Rahmani F, FitzGerald DJ, Martin S, Patel P, Prunotto M, Ormanoglu P, Thomas C, Pastan I. Anticancer Effects of Mesothelin-targeted Immunotoxin Therapy are Regulated by Tyrosine Kinase DDR1. Cancer Research. PMID 26719540 DOI: 10.1158/0008-5472.Can-15-2401  0.357
2015 Kreitman RJ, Pastan I. Immunoconjugates in the management of hairy cell leukemia. Best Practice & Research. Clinical Haematology. 28: 236-45. PMID 26614902 DOI: 10.1016/j.beha.2015.09.003  0.347
2015 Mazor R, Crown D, Addissie S, Jang Y, Kaplan G, Pastan I. Elimination of murine and human T-cell epitopes in recombinant immunotoxin eliminates neutralizing and anti-drug antibodies in vivo. Cellular & Molecular Immunology. PMID 26477977 DOI: 10.1038/cmi.2015.91  0.313
2015 Hassan R, Alewine C, Pastan I. New Life for Immunotoxin Cancer Therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26463707 DOI: 10.1158/1078-0432.CCR-15-1623  0.303
2015 Mazor R, Zhang J, Xiang L, Addissie S, Awuah P, Beers R, Hassan R, Pastan I. Recombinant Immunotoxin with T Cell Epitope Mutations that Greatly Reduce Immunogenicity for Treatment of Mesothelin Expressing Tumors. Molecular Cancer Therapeutics. PMID 26443804 DOI: 10.1158/1535-7163.MCT-15-0532  0.338
2015 Stahl S, da Silva Mateus Seidl AR, Ducret A, Kux van Geijtenbeek S, Michel S, Racek T, Birzele F, Haas AK, Rueger R, Gerg M, Niederfellner G, Pastan I, Brinkmann U. Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor. Proceedings of the National Academy of Sciences of the United States of America. 112: 10732-7. PMID 26261303 DOI: 10.1073/pnas.1512863112  0.358
2015 Weldon JE, Skarzynski M, Therres JA, Ostovitz JR, Zhou H, Kreitman RJ, Pastan I. Designing the furin-cleavable linker in recombinant immunotoxins based on Pseudomonas exotoxin A. Bioconjugate Chemistry. 26: 1120-8. PMID 25997032 DOI: 10.1021/Acs.Bioconjchem.5B00190  0.347
2015 Zhang YF, Phung Y, Gao W, Kawa S, Hassan R, Pastan I, Ho M. New high affinity monoclonal antibodies recognize non-overlapping epitopes on mesothelin for monitoring and treating mesothelioma. Scientific Reports. 5: 9928. PMID 25996440 DOI: 10.1038/srep09928  0.346
2015 Müller N, Michen S, Tietze S, Töpfer K, Schulte A, Lamszus K, Schmitz M, Schackert G, Pastan I, Temme A. Engineering NK Cells Modified With an EGFRvIII-specific Chimeric Antigen Receptor to Overexpress CXCR4 Improves Immunotherapy of CXCL12/SDF-1α-secreting Glioblastoma. Journal of Immunotherapy (Hagerstown, Md. : 1997). 38: 197-210. PMID 25962108 DOI: 10.1097/CJI.0000000000000082  0.345
2015 Hollevoet K, Mason-Osann E, Müller F, Pastan I. Methylation-associated partial down-regulation of mesothelin causes resistance to anti-mesothelin immunotoxins in a pancreatic cancer cell line. Plos One. 10: e0122462. PMID 25803818 DOI: 10.1371/journal.pone.0122462  0.331
2015 Pasetto M, Antignani A, Ormanoglu P, Buehler E, Guha R, Pastan I, Martin SE, FitzGerald DJ. Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 112: E1135-42. PMID 25713356 DOI: 10.1073/Pnas.1501958112  0.348
2015 Alewine C, Hassan R, Pastan I. Advances in anticancer immunotoxin therapy. The Oncologist. 20: 176-85. PMID 25561510 DOI: 10.1634/theoncologist.2014-0358  0.349
2015 Leshem J, Liu X, Bera T, Terabe M, Berzofsky JA, Bossenmaier B, Niederfellner G, Pastan I. Combining anti-CTLA4 with RG7787, an immunotoxin targeting mesothelin, promotes tumor eradication Journal For Immunotherapy of Cancer. 3. DOI: 10.1186/2051-1426-3-S2-P190  0.337
2015 Mueller F, Liu X, Wayne AS, Pastan I. Immunotoxin Activity Against B-Lineage Leukemia and Lymphoma Is Exposure Time Dependent: Implications for Trial Design Blood. 126: 1332-1332. DOI: 10.1182/BLOOD.V126.23.1332.1332  0.319
2015 Ali-Rahmani FG, Fitzgerald D, Martin S, Patel P, Thomas C, Pastan I. Abstract 5357: Inhibition of collagen receptor discoidin domain receptor-1 (DDR1) tyrosine kinase enhances cytotoxicity of anti-mesothelin immunotoxin for cancer therapy Cancer Research. 75: 5357-5357. DOI: 10.1158/1538-7445.Am2015-5357  0.33
2015 Alewine CC, Kolyvas E, Boslett K, Pastan I. Abstract 2566: Combination of taxanes with mesothelin-targeted immunotoxin RG7787 induces synergistic killing of pancreatic cancer Cancer Research. 75: 2566-2566. DOI: 10.1158/1538-7445.Am2015-2566  0.317
2015 Alewine CC, Kolyvas E, Pastan I. Abstract C163: Understanding the mechanism for synergistic anti-tumor activity of a meosthelin-targeted immunotoxin and taxanes Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-C163  0.327
2014 Pak Y, Pastan I, Kreitman RJ, Lee B. Effect of antigen shedding on targeted delivery of immunotoxins in solid tumors from a mathematical model. Plos One. 9: e110716. PMID 25343405 DOI: 10.1371/journal.pone.0110716  0.328
2014 Alewine C, Xiang L, Yamori T, Niederfellner G, Bosslet K, Pastan I. Efficacy of RG7787, a next-generation mesothelin-targeted immunotoxin, against triple-negative breast and gastric cancers. Molecular Cancer Therapeutics. 13: 2653-61. PMID 25239937 DOI: 10.1158/1535-7163.MCT-14-0132  0.302
2014 Hassan R, Kindler HL, Jahan T, Bazhenova L, Reck M, Thomas A, Pastan I, Parno J, O'Shannessy DJ, Fatato P, Maltzman JD, Wallin BA. Phase II clinical trial of amatuximab, a chimeric antimesothelin antibody with pemetrexed and cisplatin in advanced unresectable pleural mesothelioma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 5927-36. PMID 25231400 DOI: 10.1158/1078-0432.Ccr-14-0804  0.314
2014 Zhang J, Bera TK, Liu W, Du X, Alewine C, Hassan R, Pastan I. Megakaryocytic potentiating factor and mature mesothelin stimulate the growth of a lung cancer cell line in the peritoneal cavity of mice. Plos One. 9: e104388. PMID 25118887 DOI: 10.1371/journal.pone.0104388  0.323
2014 Wright SE, Rewers-Felkins KA, Quinlin I, Chowdhury NI, Ahmed J, Eldridge PW, Srivastava SK, Pastan I. TGFα-PE38 enhances cytotoxic T-lymphocyte killing of breast cancer cells. Oncology Letters. 7: 2113-2117. PMID 24932299 DOI: 10.3892/ol.2014.1969  0.347
2014 Hollevoet K, Mason-Osann E, Liu XF, Imhof-Jung S, Niederfellner G, Pastan I. In vitro and in vivo activity of the low-immunogenic antimesothelin immunotoxin RG7787 in pancreatic cancer. Molecular Cancer Therapeutics. 13: 2040-9. PMID 24928849 DOI: 10.1158/1535-7163.MCT-14-0089-T  0.339
2014 King C, Garza EN, Mazor R, Linehan JL, Pastan I, Pepper M, Baker D. Removing T-cell epitopes with computational protein design. Proceedings of the National Academy of Sciences of the United States of America. 111: 8577-82. PMID 24843166 DOI: 10.1073/Pnas.1321126111  0.301
2014 Pastan I, Hassan R. Discovery of mesothelin and exploiting it as a target for immunotherapy. Cancer Research. 74: 2907-12. PMID 24824231 DOI: 10.1158/0008-5472.CAN-14-0337  0.318
2014 Mazor R, Eberle JA, Hu X, Vassall AN, Onda M, Beers R, Lee EC, Kreitman RJ, Lee B, Baker D, King C, Hassan R, Benhar I, Pastan I. Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes. Proceedings of the National Academy of Sciences of the United States of America. 111: 8571-6. PMID 24799704 DOI: 10.1073/Pnas.1405153111  0.586
2014 Wayne AS, Fitzgerald DJ, Kreitman RJ, Pastan I. Immunotoxins for leukemia. Blood. 123: 2470-7. PMID 24578503 DOI: 10.1182/blood-2014-01-492256  0.352
2014 Terrier B, Nagata S, Ise T, Rosenzwajg M, Pastan I, Klatzmann D, Saadoun D, Cacoub P. CD21(-/low) marginal zone B cells highly express Fc receptor-like 5 protein and are killed by anti-Fc receptor-like 5 immunotoxins in hepatitis C virus-associated mixed cryoglobulinemia vasculitis. Arthritis & Rheumatology (Hoboken, N.J.). 66: 433-43. PMID 24504816 DOI: 10.1002/art.38222  0.301
2014 Hollevoet K, Antignani A, Fitzgerald DJ, Pastan I. Combining the antimesothelin immunotoxin SS1P with the BH3-mimetic ABT-737 induces cell death in SS1P-resistant pancreatic cancer cells. Journal of Immunotherapy (Hagerstown, Md. : 1997). 37: 8-15. PMID 24316551 DOI: 10.1097/CJI.0000000000000010  0.352
2014 Liu XF, Xiang L, FitzGerald DJ, Pastan I. Antitumor effects of immunotoxins are enhanced by lowering HCK or treatment with SRC kinase inhibitors. Molecular Cancer Therapeutics. 13: 82-9. PMID 24145282 DOI: 10.1158/1535-7163.MCT-13-0726  0.311
2014 Ali-Rahmani F, Fitzgerald D, Martin S, Patel P, Thomas C, Pastan I. Abstract 5428: Inhibition of collagen receptor discoidin domain receptor-1 (DDR1) tyrosine kinase enhances cytotoxicity of anti-mesothelin immunotoxin Cancer Research. 74: 5428-5428. DOI: 10.1158/1538-7445.Am2014-5428  0.339
2014 Niederfellner G, Bauss F, Imhof-Jung S, Hesse F, Kronenberg S, Staak R, Lechmann M, Krippendorff B, Richter W, Mateus R, Kollmorgen G, Brinkmann U, Onda M, Pastan I, Bosslet K. Abstract 4510: RG7787 - a novel de-immunized PE based fusion protein for therapy of mesothelin-positive solid tumors Cancer Research. 74: 4510-4510. DOI: 10.1158/1538-7445.Am2014-4510  0.305
2014 Pastan I, Hollevoet K, Mason-Osann E, Alewine C, Liu X. Abstract 4505: Anti-tumor activity in pancreatic cancer of a low immunogenic and clinically optimized anti-mesothelin immunotoxin RG7787 Cancer Research. 74: 4505-4505. DOI: 10.1158/1538-7445.Am2014-4505  0.344
2014 Antignani A, Pasetto M, Choo C, Angelus E, Mathews L, Guha R, Shinn P, Ferrer M, Thomas CJ, Pastan I, Fitzgerald DJ. Abstract 2907: Everolimus enhances the cytotoxic action of the immunotoxin, HA22, directed to CD22 on B-cell malignancies Cancer Research. 74: 2907-2907. DOI: 10.1158/1538-7445.Am2014-2907  0.352
2013 Hassan R, Miller AC, Sharon E, Thomas A, Reynolds JC, Ling A, Kreitman RJ, Miettinen MM, Steinberg SM, Fowler DH, Pastan I. Major cancer regressions in mesothelioma after treatment with an anti-mesothelin immunotoxin and immune suppression. Science Translational Medicine. 5: 208ra147. PMID 24154601 DOI: 10.1126/scitranslmed.3006941  0.341
2013 Mattoo AR, Pastan I, Fitzgerald D. Combination treatments with the PKC inhibitor, enzastaurin, enhance the cytotoxicity of the anti-mesothelin immunotoxin, SS1P. Plos One. 8: e75576. PMID 24130723 DOI: 10.1371/journal.pone.0075576  0.326
2013 Molavi O, Xiong XB, Douglas D, Kneteman N, Nagata S, Pastan I, Chu Q, Lavasanifar A, Lai R. Anti-CD30 antibody conjugated liposomal doxorubicin with significantly improved therapeutic efficacy against anaplastic large cell lymphoma. Biomaterials. 34: 8718-25. PMID 23942212 DOI: 10.1016/J.Biomaterials.2013.07.068  0.309
2013 Huang YH, Terabe M, Pendleton CD, Stewart Khursigara D, Bera TK, Pastan I, Berzofsky JA. Identification and enhancement of HLA-A2.1-restricted CTL epitopes in a new human cancer antigen-POTE. Plos One. 8: e64365. PMID 23750208 DOI: 10.1371/journal.pone.0064365  0.32
2013 Choi BD, Pastan I, Bigner DD, Sampson JH. A novel bispecific antibody recruits T cells to eradicate tumors in the "immunologically privileged" central nervous system. Oncoimmunology. 2: e23639. PMID 23734318 DOI: 10.4161/Onci.23639  0.32
2013 Wei H, Bera TK, Wayne AS, Xiang L, Colantonio S, Chertov O, Pastan I. A modified form of diphthamide causes immunotoxin resistance in a lymphoma cell line with a deletion of the WDR85 gene. The Journal of Biological Chemistry. 288: 12305-12. PMID 23486472 DOI: 10.1074/jbc.M113.461343  0.339
2013 Ueno T, Kobayashi N, Nakayama M, Takashima Y, Ohse T, Pastan I, Pippin JW, Shankland SJ, Uesugi N, Matsusaka T, Nagata M. Aberrant Notch1-dependent effects on glomerular parietal epithelial cells promotes collapsing focal segmental glomerulosclerosis with progressive podocyte loss. Kidney International. 83: 1065-75. PMID 23447065 DOI: 10.1038/ki.2013.48  0.321
2013 Choi BD, Kuan CT, Cai M, Archer GE, Mitchell DA, Gedeon PC, Sanchez-Perez L, Pastan I, Bigner DD, Sampson JH. Systemic administration of a bispecific antibody targeting EGFRvIII successfully treats intracerebral glioma. Proceedings of the National Academy of Sciences of the United States of America. 110: 270-5. PMID 23248284 DOI: 10.1073/Pnas.1219817110  0.356
2013 Weldon JE, Xiang L, Zhang J, Beers R, Walker DA, Onda M, Hassan R, Pastan I. A recombinant immunotoxin against the tumor-associated antigen mesothelin reengineered for high activity, low off-target toxicity, and reduced antigenicity. Molecular Cancer Therapeutics. 12: 48-57. PMID 23136186 DOI: 10.1158/1535-7163.Mct-12-0336  0.344
2013 Mattoo AR, Pastan I, Fitzgerald D. Abstract 5490: The cytotoxic activity of the anti-mesothelin immunotoxin SS1P is enhanced by the PKC inhibitor enzastaurin. Cancer Research. 73: 5490-5490. DOI: 10.1158/1538-7445.Am2013-5490  0.317
2013 Hollevoet K, Antignani A, Fitzgerald DJ, Pastan I. Abstract 5482: Combining the anti-mesothelin immunotoxin SS1P with the BH3-mimetic ABT-737 induces cell death in SS1P-resistant pancreatic cancer cell lines. Cancer Research. 73: 5482-5482. DOI: 10.1158/1538-7445.Am2013-5482  0.377
2013 Mazor R, Vassall AN, Eberle JA, Beers R, Hu X, Benhar I, Pastan I. Abstract 4334: Identification and elimination of T-cell epitopes in recombinant immunotoxins used to treat cancer. Cancer Research. 73: 4334-4334. DOI: 10.1158/1538-7445.Am2013-4334  0.592
2012 Mazor R, Vassall AN, Eberle JA, Beers R, Weldon JE, Venzon DJ, Tsang KY, Benhar I, Pastan I. Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A. Proceedings of the National Academy of Sciences of the United States of America. 109: E3597-603. PMID 23213206 DOI: 10.1073/Pnas.1218138109  0.595
2012 Tortorella LL, Pipalia NH, Mukherjee S, Pastan I, Fitzgerald D, Maxfield FR. Efficiency of immunotoxin cytotoxicity is modulated by the intracellular itinerary. Plos One. 7: e47320. PMID 23056628 DOI: 10.1371/Journal.Pone.0047320  0.551
2012 Ma J, Tang WK, Esser L, Pastan I, Xia D. Recognition of mesothelin by the therapeutic antibody MORAb-009: structural and mechanistic insights. The Journal of Biological Chemistry. 287: 33123-31. PMID 22787150 DOI: 10.1074/jbc.M112.381756  0.338
2012 Liu W, Onda M, Lee B, Kreitman RJ, Hassan R, Xiang L, Pastan I. Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes. Proceedings of the National Academy of Sciences of the United States of America. 109: 11782-7. PMID 22753489 DOI: 10.1073/pnas.1209292109  0.38
2012 Liu XF, Bera TK, Kahue C, Escobar T, Fei Z, Raciti GA, Pastan I. ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells. Plos One. 7: e38130. PMID 22666460 DOI: 10.1371/journal.pone.0038130  0.32
2012 Pak Y, Zhang Y, Pastan I, Lee B. Antigen shedding may improve efficiencies for delivery of antibody-based anticancer agents in solid tumors. Cancer Research. 72: 3143-52. PMID 22562466 DOI: 10.1158/0008-5472.CAN-11-3925  0.328
2012 Baskar S, Wiestner A, Wilson WH, Pastan I, Rader C. Targeting malignant B cells with an immunotoxin against ROR1. Mabs. 4: 349-61. PMID 22531447 DOI: 10.4161/Mabs.19870  0.352
2012 Wei H, Xiang L, Wayne AS, Chertov O, FitzGerald DJ, Bera TK, Pastan I. Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy. Proceedings of the National Academy of Sciences of the United States of America. 109: 6898-903. PMID 22509046 DOI: 10.1073/pnas.1204523109  0.321
2012 Kelly RJ, Sharon E, Pastan I, Hassan R. Mesothelin-targeted agents in clinical trials and in preclinical development. Molecular Cancer Therapeutics. 11: 517-25. PMID 22351743 DOI: 10.1158/1535-7163.MCT-11-0454  0.303
2012 Bera TK, Walker DA, Sherins RJ, Pastan I. POTE protein, a cancer-testis antigen, is highly expressed in spermatids in human testis and is associated with apoptotic cells. Biochemical and Biophysical Research Communications. 417: 1271-4. PMID 22234308 DOI: 10.1016/j.bbrc.2011.12.125  0.305
2012 Biberacher V, Decker T, Oelsner M, Wagner M, Bogner C, Schmidt B, Kreitman RJ, Peschel C, Pastan I, Meyer Zum Büschenfelde C, Ringshausen I. The cytotoxicity of anti-CD22 immunotoxin is enhanced by bryostatin 1 in B-cell lymphomas through CD22 upregulation and PKC-βII depletion. Haematologica. 97: 771-9. PMID 22180432 DOI: 10.3324/Haematol.2011.049155  0.315
2012 Liu W, Onda M, Kim C, Xiang L, Weldon JE, Lee B, Pastan I. A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity. Protein Engineering, Design & Selection : Peds. 25: 1-6. PMID 22101015 DOI: 10.1093/Protein/Gzr053  0.331
2012 Liu XF, Xiang L, Zhang Y, Becker KG, Bera TK, Pastan I. CAPC negatively regulates NF-κB activation and suppresses tumor growth and metastasis. Oncogene. 31: 1673-82. PMID 21822313 DOI: 10.1038/onc.2011.355  0.34
2012 Haso W, Lee DW, Pastan I, Dimitrov DS, Mackall CL, Orentas RJ. A New High Activity Anti-CD22 Chimeric Antigen Receptor (CAR) Targeting B Cell Leukemia. Blood. 120: 2611-2611. DOI: 10.1182/Blood.V120.21.2611.2611  0.317
2012 Wei H, Xiang L, Wayne AS, Pastan I. Decreased Expression of Diphthamide Genes Is Responsible for the Resistance to the Anti-CD22 Immunotoxin Moxetumomab Pasudotox (m. pasudotox) in Acute Lymphoblastic Leukemia (ALL)/Non-Hodgkin Lymphoma (NHL) Cell Lines. Blood. 120: 2443-2443. DOI: 10.1182/BLOOD.V120.21.2443.2443  0.325
2012 Haso W, Lee D, Morgan R, Pastan I, Mackall C, Orentas RJ. Abstract 3504: Generation and optimization of a chimeric antigen receptor against human CD22: A new immunotherapeutic agent for adoptive immunotherapy Cancer Research. 72: 3504-3504. DOI: 10.1158/1538-7445.Am2012-3504  0.318
2011 Kawa S, Onda M, Ho M, Kreitman RJ, Bera TK, Pastan I. The improvement of an anti-CD22 immunotoxin: conversion to single-chain and disulfide stabilized form and affinity maturation by alanine scan. Mabs. 3: 479-86. PMID 22048691 DOI: 10.4161/mabs.3.5.17228  0.315
2011 Kreitman RJ, Pastan I. Antibody fusion proteins: anti-CD22 recombinant immunotoxin moxetumomab pasudotox. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 6398-405. PMID 22003067 DOI: 10.1158/1078-0432.CCR-11-0487  0.377
2011 FitzGerald DJ, Wayne AS, Kreitman RJ, Pastan I. Treatment of hematologic malignancies with immunotoxins and antibody-drug conjugates. Cancer Research. 71: 6300-9. PMID 21998010 DOI: 10.1158/0008-5472.CAN-11-1374  0.328
2011 Du X, Xiang L, Mackall C, Pastan I. Killing of resistant cancer cells with low Bak by a combination of an antimesothelin immunotoxin and a TRAIL Receptor 2 agonist antibody. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 5926-34. PMID 21813632 DOI: 10.1158/1078-0432.CCR-11-1235  0.345
2011 Zhang Y, Chertov O, Zhang J, Hassan R, Pastan I. Cytotoxic activity of immunotoxin SS1P is modulated by TACE-dependent mesothelin shedding. Cancer Research. 71: 5915-22. PMID 21775520 DOI: 10.1158/0008-5472.CAN-11-0466  0.338
2011 Fei Z, Bera TK, Liu X, Xiang L, Pastan I. Ankrd26 gene disruption enhances adipogenesis of mouse embryonic fibroblasts. The Journal of Biological Chemistry. 286: 27761-8. PMID 21669876 DOI: 10.1074/jbc.M111.248435  0.318
2011 Fitzgerald DJ, Moskatel E, Ben-Josef G, Traini R, Tendler T, Sharma A, Antignani A, Mussai F, Wayne A, Kreitman RJ, Pastan I. Enhancing immunotoxin cell-killing activity via combination therapy with ABT-737. Leukemia & Lymphoma. 52: 79-81. PMID 21599608 DOI: 10.3109/10428194.2011.569961  0.372
2011 Weldon JE, Pastan I. A guide to taming a toxin--recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer. The Febs Journal. 278: 4683-700. PMID 21585657 DOI: 10.1111/J.1742-4658.2011.08182.X  0.323
2011 Pastan I, Onda M, Weldon J, Fitzgerald D, Kreitman R. Immunotoxins with decreased immunogenicity and improved activity. Leukemia & Lymphoma. 52: 87-90. PMID 21504287 DOI: 10.3109/10428194.2011.573039  0.363
2011 Onda M, Beers R, Xiang L, Lee B, Weldon JE, Kreitman RJ, Pastan I. Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes. Proceedings of the National Academy of Sciences of the United States of America. 108: 5742-7. PMID 21436054 DOI: 10.1073/Pnas.1102746108  0.365
2011 Kuan CT, Wakiya K, Keir ST, Li J, Herndon JE, Pastan I, Bigner DD. Affinity-matured anti-glycoprotein NMB recombinant immunotoxins targeting malignant gliomas and melanomas. International Journal of Cancer. Journal International Du Cancer. 129: 111-21. PMID 20824708 DOI: 10.1002/Ijc.25645  0.362
2011 Ho M, Feng M, Fisher RJ, Rader C, Pastan I. A novel high-affinity human monoclonal antibody to mesothelin. International Journal of Cancer. Journal International Du Cancer. 128: 2020-30. PMID 20635390 DOI: 10.1002/Ijc.25557  0.348
2011 Lechleider R, Pastan I. Advances in the development of Anti-CD22 immunotoxins containing Pseudomonas exotoxin for treatment of hematologic malignancies Journal of Cancer Science and Therapy. 3: 50-52. DOI: 10.4172/1948-5956.1000057  0.336
2011 Kreitman RJ, Singh R, Stetler-Stevenson M, Waldmann TA, Pastan I. Regression of Adult T-Cell Leukemia with Anti-CD25 Recombinant Immunotoxin LMB-2 Preceded by Chemotherapy Blood. 118: 2575-2575. DOI: 10.1182/Blood.V118.21.2575.2575  0.341
2010 Hansen JK, Weldon JE, Xiang L, Beers R, Onda M, Pastan I. A recombinant immunotoxin targeting CD22 with low immunogenicity, low nonspecific toxicity, and high antitumor activity in mice. Journal of Immunotherapy (Hagerstown, Md. : 1997). 33: 297-304. PMID 20445350 DOI: 10.1097/Cji.0B013E3181Cd1164  0.349
2010 Zhang Y, Hansen JK, Xiang L, Kawa S, Onda M, Ho M, Hassan R, Pastan I. A flow cytometry method to quantitate internalized immunotoxins shows that taxol synergistically increases cellular immunotoxins uptake. Cancer Research. 70: 1082-9. PMID 20103626 DOI: 10.1158/0008-5472.Can-09-2405  0.313
2010 Bogner C, Dechow T, Ringshausen I, Wagner M, Oelsner M, Lutzny G, Licht T, Peschel C, Pastan I, Kreitman RJ, Decker T. Immunotoxin BL22 induces apoptosis in mantle cell lymphoma (MCL) cells dependent on Bcl-2 expression. British Journal of Haematology. 148: 99-109. PMID 19821820 DOI: 10.1111/j.1365-2141.2009.07939.x  0.354
2010 Pastan I, Roth J, Macchia V. Binding of hormone to tissue: the first step in polypeptide hormone action. Proceedings of the National Academy of Sciences of the United States of America. 56: 1802-9. PMID 16591423 DOI: 10.1073/PNAS.56.6.1802  0.357
2010 Kreitman RJ, Tallman MS, Coutre S, Robak T, Wilson WH, Stetler-Stevenson M, Noel P, FitzGerald DJ, Buzoianu M, Lechleider RJ, Pastan I. A Phase 1 Study of Moxetumomab Pasudotox, An Anti-CD22 Recombinant Immunotoxin, In Relapsed/Refractory Hairy Cell Leukemia (HCL): Updated Results Blood. 116: 2516-2516. DOI: 10.1182/BLOOD.V116.21.2516.2516  0.302
2010 Mussai FJ, Campana D, Bhojwani D, Stetler-Stevenson M, Steinberg SM, Morisot S, Civin CI, Wayne AS, Pastan I. Abstract 4356: Cytotoxicity of the anti-CD22 immunotoxin HA22 against pediatric acute lymphoblastic leukemia (ALL) Cancer Research. 70: 4356-4356. DOI: 10.1158/1538-7445.Am10-4356  0.312
2009 Xiao X, Ho M, Zhu Z, Pastan I, Dimitrov DS. Identification and characterization of fully human anti-CD22 monoclonal antibodies. Mabs. 1: 297-303. PMID 20065646 DOI: 10.4161/mabs.1.3.8113  0.336
2009 Kreitman RJ, Fitzgerald DJ, Pastan I. Approach to the patient after relapse of hairy cell leukemia. Leukemia & Lymphoma. 50: 32-7. PMID 19814696 DOI: 10.3109/10428190903142216  0.323
2009 Nagata S, Pastan I. Removal of B cell epitopes as a practical approach for reducing the immunogenicity of foreign protein-based therapeutics. Advanced Drug Delivery Reviews. 61: 977-85. PMID 19679153 DOI: 10.1016/j.addr.2009.07.014  0.341
2009 Liu XF, Bera TK, Liu LJ, Pastan I. A primate-specific POTE-actin fusion protein plays a role in apoptosis. Apoptosis : An International Journal On Programmed Cell Death. 14: 1237-44. PMID 19669888 DOI: 10.1007/s10495-009-0392-0  0.344
2009 Ho M, Pastan I. Display and selection of scFv antibodies on HEK-293T cells. Methods in Molecular Biology (Clifton, N.J.). 562: 99-113. PMID 19554290 DOI: 10.1007/978-1-60327-302-2_8  0.364
2009 Nagata S, Ise T, Pastan I. Fc receptor-like 3 protein expressed on IL-2 nonresponsive subset of human regulatory T cells. Journal of Immunology (Baltimore, Md. : 1950). 182: 7518-26. PMID 19494275 DOI: 10.4049/jimmunol.0802230  0.35
2009 Feng Y, Xiao X, Zhu Z, Streaker E, Ho M, Pastan I, Dimitrov DS. A novel human monoclonal antibody that binds with high affinity to mesothelin-expressing cells and kills them by antibody-dependent cell-mediated cytotoxicity. Molecular Cancer Therapeutics. 8: 1113-8. PMID 19417159 DOI: 10.1158/1535-7163.MCT-08-0945  0.359
2009 Ho M, Pastan I. In vitro antibody affinity maturation targeting germline hotspots. Methods in Molecular Biology (Clifton, N.J.). 525: 293-308, xiv. PMID 19252855 DOI: 10.1007/978-1-59745-554-1_15  0.317
2009 Ho M, Pastan I. Mammalian cell display for antibody engineering. Methods in Molecular Biology (Clifton, N.J.). 525: 337-52, xiv. PMID 19252852 DOI: 10.1007/978-1-59745-554-1_18  0.352
2009 Anaganti S, Hansen JK, Ha D, Hahn Y, Chertov O, Pastan I, Bera TK. Non-AUG translational initiation of a short CAPC transcript generating protein isoform. Biochemical and Biophysical Research Communications. 380: 508-13. PMID 19250639 DOI: 10.1016/J.Bbrc.2009.01.089  0.324
2009 Carpenito C, Milone MC, Hassan R, Simonet JC, Lakhal M, Suhoski MM, Varela-Rohena A, Haines KM, Heitjan DF, Albelda SM, Carroll RG, Riley JL, Pastan I, June CH. Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains. Proceedings of the National Academy of Sciences of the United States of America. 106: 3360-5. PMID 19211796 DOI: 10.1073/Pnas.0813101106  0.343
2009 Sathyanarayana BK, Hahn Y, Patankar MS, Pastan I, Lee B. Mesothelin, Stereocilin, and Otoancorin are predicted to have superhelical structures with ARM-type repeats. Bmc Structural Biology. 9: 1. PMID 19128473 DOI: 10.1186/1472-6807-9-1  0.312
2009 Weldon JE, Xiang L, Chertov O, Margulies I, Kreitman RJ, FitzGerald DJ, Pastan I. A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity. Blood. 113: 3792-800. PMID 18988862 DOI: 10.1182/Blood-2008-08-173195  0.341
2008 Laheru DA, Cohen SJ, Phillips M, Armstrong DK, Brahmer J, Jaffee EM, Weil S, Pastan I, Hassan R. A phase I study of MORab-009, a monoclonal antibody against mesothelin, in mesothelioma, pancreatic and ovarian cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 26: 3578. PMID 27949713 DOI: 10.1200/Jco.2008.26.15_Suppl.3578  0.355
2008 Zhang Y, Pastan I. High shed antigen levels within tumors: an additional barrier to immunoconjugate therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 7981-6. PMID 19088013 DOI: 10.1158/1078-0432.CCR-08-0324  0.305
2008 Motoyoshi Y, Matsusaka T, Saito A, Pastan I, Willnow TE, Mizutani S, Ichikawa I. Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuria. Kidney International. 74: 1262-9. PMID 18769366 DOI: 10.1038/ki.2008.405  0.302
2008 Onda M, Beers R, Xiang L, Nagata S, Wang QC, Pastan I. An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes. Proceedings of the National Academy of Sciences of the United States of America. 105: 11311-6. PMID 18678888 DOI: 10.1073/pnas.0804851105  0.374
2008 Das S, Hahn Y, Walker DA, Nagata S, Willingham MC, Peehl DM, Bera TK, Lee B, Pastan I. Topology of NGEP, a prostate-specific cell:cell junction protein widely expressed in many cancers of different grade level. Cancer Research. 68: 6306-12. PMID 18676855 DOI: 10.1158/0008-5472.CAN-08-0870  0.348
2008 Bera TK, Saint Fleur A, Ha D, Yamada M, Lee Y, Lee B, Hahn Y, Kaufman DS, Pera M, Pastan I. Selective POTE paralogs on chromosome 2 are expressed in human embryonic stem cells. Stem Cells and Development. 17: 325-32. PMID 18447647 DOI: 10.1089/Scd.2007.0079  0.343
2008 Epel M, Carmi I, Soueid-Baumgarten S, Oh SK, Bera T, Pastan I, Berzofsky J, Reiter Y. Targeting TARP, a novel breast and prostate tumor-associated antigen, with T cell receptor-like human recombinant antibodies. European Journal of Immunology. 38: 1706-20. PMID 18446790 DOI: 10.1002/eji.200737524  0.357
2008 Levitin F, Weiss M, Hahn Y, Stern O, Papke RL, Matusik R, Nandana SR, Ziv R, Pichinuk E, Salame S, Bera T, Vincent J, Lee B, Pastan I, Wreschner DH. PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activity. The Journal of Biological Chemistry. 283: 16928-39. PMID 18387948 DOI: 10.1074/Jbc.M801454200  0.318
2008 Ise T, Das S, Nagata S, Maeda H, Lee Y, Onda M, Anver MR, Bera TK, Pastan I. Expression of POTE protein in human testis detected by novel monoclonal antibodies. Biochemical and Biophysical Research Communications. 365: 603-8. PMID 17996727 DOI: 10.1016/j.bbrc.2007.10.195  0.328
2008 Du X, Nagata S, Ise T, Stetler-Stevenson M, Pastan I. FCRL1 on chronic lymphocytic leukemia, hairy cell leukemia, and B-cell non-Hodgkin lymphoma as a target of immunotoxins. Blood. 111: 338-43. PMID 17895404 DOI: 10.1182/blood-2007-07-102350  0.354
2008 Kreitman RJ, Wilson WH, Stetler-Stevenson M, Noel P, FitzGerald DJ, Pastan I. Interim Phase I Results of Recombinant Immunotoxin HA22 in Patients with Hairy Cell and Chronic Lymphocytic Leukemias Blood. 112: 3160-3160. DOI: 10.1182/BLOOD.V112.11.3160.3160  0.305
2008 Nagata S, Ise T, Pastan I. IL-2 non-responsive subset of human natural regulatory T cells expresses Fc receptor-like 3 protein The Faseb Journal. 22: 381-381. DOI: 10.1096/Fasebj.22.2_Supplement.381  0.301
2007 Steinbach D, Onda M, Voigt A, Dawczynski K, Wittig S, Hassan R, Gruhn B, Pastan I. Mesothelin, a possible target for immunotherapy, is expressed in primary AML cells. European Journal of Haematology. 79: 281-6. PMID 17803679 DOI: 10.1111/j.1600-0609.2007.00928.x  0.31
2007 Du X, Ho M, Pastan I. New immunotoxins targeting CD123, a stem cell antigen on acute myeloid leukemia cells. Journal of Immunotherapy (Hagerstown, Md. : 1997). 30: 607-13. PMID 17667524 DOI: 10.1097/CJI.0b013e318053ed8e  0.319
2007 Yokokawa J, Bera TK, Palena C, Cereda V, Remondo C, Gulley JL, Arlen PM, Pastan I, Schlom J, Tsang KY. Identification of cytotoxic T-lymphocyte epitope(s) and its agonist epitope(s) of a novel target for vaccine therapy (PAGE4). International Journal of Cancer. Journal International Du Cancer. 121: 595-605. PMID 17397028 DOI: 10.1002/ijc.22698  0.321
2007 Das S, Hahn Y, Nagata S, Willingham MC, Bera TK, Lee B, Pastan I. NGEP, a prostate-specific plasma membrane protein that promotes the association of LNCaP cells. Cancer Research. 67: 1594-601. PMID 17308099 DOI: 10.1158/0008-5472.CAN-06-2673  0.321
2007 Pastan I, Hassan R, FitzGerald DJ, Kreitman RJ. Immunotoxin treatment of cancer. Annual Review of Medicine. 58: 221-37. PMID 17059365 DOI: 10.1146/annurev.med.58.070605.115320  0.331
2007 Ahuja Y, Stetler-Stevenson M, Kreitman RJ, Pastan I, Wayne AS. Pre-Clinical Evaluation of the Anti-CD22 Immunotoxin CAT-8015 in Combination with Chemotherapy Agents for Childhood B-Precursor Acute Lymphoblastic Leukemia (Pre-B ALL). Blood. 110: 865-865. DOI: 10.1182/BLOOD.V110.11.865.865  0.313
2006 Onda M, Nagata S, FitzGerald DJ, Beers R, Fisher RJ, Vincent JJ, Lee B, Nakamura M, Hwang J, Kreitman RJ, Hassan R, Pastan I. Characterization of the B cell epitopes associated with a truncated form of Pseudomonas exotoxin (PE38) used to make immunotoxins for the treatment of cancer patients. Journal of Immunology (Baltimore, Md. : 1950). 177: 8822-34. PMID 17142785 DOI: 10.4049/Jimmunol.177.12.8822  0.35
2006 Lee Y, Ise T, Ha D, Saint Fleur A, Hahn Y, Liu XF, Nagata S, Lee B, Bera TK, Pastan I. Evolution and expression of chimeric POTE-actin genes in the human genome. Proceedings of the National Academy of Sciences of the United States of America. 103: 17885-90. PMID 17101985 DOI: 10.1073/pnas.0608344103  0.316
2006 Li Z, Mahesh SP, Shen de F, Liu B, Siu WO, Hwang FS, Wang QC, Chan CC, Pastan I, Nussenblatt RB. Eradication of tumor colonization and invasion by a B cell-specific immunotoxin in a murine model for human primary intraocular lymphoma. Cancer Research. 66: 10586-93. PMID 17079483 DOI: 10.1158/0008-5472.CAN-06-1981  0.318
2006 Kreitman RJ, Pastan I. Immunotoxins in the treatment of hematologic malignancies. Current Drug Targets. 7: 1301-11. PMID 17073592 DOI: 10.2174/138945006778559139  0.366
2006 Gubbels JA, Belisle J, Onda M, Rancourt C, Migneault M, Ho M, Bera TK, Connor J, Sathyanarayana BK, Lee B, Pastan I, Patankar MS. Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors. Molecular Cancer. 5: 50. PMID 17067392 DOI: 10.1186/1476-4598-5-50  0.3
2006 Kreitman RJ, Pastan I. BL22 and lymphoid malignancies. Best Practice & Research. Clinical Haematology. 19: 685-99. PMID 16997177 DOI: 10.1016/j.beha.2006.06.009  0.334
2006 Kreitman RJ, Pastan I. Immunotoxins in the treatment of refractory hairy cell leukemia. Hematology/Oncology Clinics of North America. 20: 1137-51, viii. PMID 16990113 DOI: 10.1016/j.hoc.2006.06.009  0.358
2006 Pastan I, Hassan R, Fitzgerald DJ, Kreitman RJ. Immunotoxin therapy of cancer. Nature Reviews. Cancer. 6: 559-65. PMID 16794638 DOI: 10.1038/nrc1891  0.332
2006 Ho M, Nagata S, Pastan I. Isolation of anti-CD22 Fv with high affinity by Fv display on human cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 9637-42. PMID 16763048 DOI: 10.1073/pnas.0603653103  0.378
2006 Ise T, Kreitman RJ, Pastan I, Nagata S. Sandwich ELISAs for soluble immunoglobulin superfamily receptor translocation-associated 2 (IRTA2)/FcRH5 (CD307) proteins in human sera. Clinical Chemistry and Laboratory Medicine : Cclm / Fescc. 44: 594-602. PMID 16681430 DOI: 10.1515/CCLM.2006.115  0.363
2006 Egland KA, Liu XF, Squires S, Nagata S, Man YG, Bera TK, Onda M, Vincent JJ, Strausberg RL, Lee B, Pastan I. High expression of a cytokeratin-associated protein in many cancers. Proceedings of the National Academy of Sciences of the United States of America. 103: 5929-34. PMID 16585525 DOI: 10.1073/Pnas.0601296103  0.326
2006 Korherr C, Gille H, Schäfer R, Koenig-Hoffmann K, Dixelius J, Egland KA, Pastan I, Brinkmann U. Identification of proangiogenic genes and pathways by high-throughput functional genomics: TBK1 and the IRF3 pathway. Proceedings of the National Academy of Sciences of the United States of America. 103: 4240-5. PMID 16537515 DOI: 10.1073/Pnas.0511319103  0.305
2006 Attia P, Powell DJ, Maker AV, Kreitman RJ, Pastan I, Rosenberg SA. Selective elimination of human regulatory T lymphocytes in vitro with the recombinant immunotoxin LMB-2. Journal of Immunotherapy (Hagerstown, Md. : 1997). 29: 208-14. PMID 16531821 DOI: 10.1097/01.cji.0000187959.45803.0c  0.323
2006 Hassan R, Remaley AT, Sampson ML, Zhang J, Cox DD, Pingpank J, Alexander R, Willingham M, Pastan I, Onda M. Detection and quantitation of serum mesothelin, a tumor marker for patients with mesothelioma and ovarian cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 447-53. PMID 16428485 DOI: 10.1158/1078-0432.CCR-05-1477  0.424
2005 Yokokawa J, Palena C, Arlen P, Hassan R, Ho M, Pastan I, Schlom J, Tsang KY. Identification of novel human CTL epitopes and their agonist epitopes of mesothelin. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 6342-51. PMID 16144939 DOI: 10.1158/1078-0432.CCR-05-0596  0.35
2005 Onda M, Willingham M, Nagata S, Bera TK, Beers R, Ho M, Hassan R, Kreitman RJ, Pastan I. New monoclonal antibodies to mesothelin useful for immunohistochemistry, fluorescence-activated cell sorting, Western blotting, and ELISA. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 5840-6. PMID 16115924 DOI: 10.1158/1078-0432.CCR-05-0578  0.36
2005 Hassan R, Kreitman RJ, Pastan I, Willingham MC. Localization of mesothelin in epithelial ovarian cancer. Applied Immunohistochemistry & Molecular Morphology : Aimm / Official Publication of the Society For Applied Immunohistochemistry. 13: 243-7. PMID 16082249 DOI: 10.1097/01.pai.00000141545.36485.d6  0.308
2005 Asano T, Niimura F, Pastan I, Fogo AB, Ichikawa I, Matsusaka T. Permanent genetic tagging of podocytes: fate of injured podocytes in a mouse model of glomerular sclerosis. Journal of the American Society of Nephrology : Jasn. 16: 2257-62. PMID 15987751 DOI: 10.1681/ASN.2004121134  0.3
2005 Soler-García AA, Maitra R, Kumar V, Ise T, Nagata S, Beers R, Bera TK, Pastan I. The PATE gene is expressed in the accessory tissues of the human male genital tract and encodes a secreted sperm-associated protein. Reproduction (Cambridge, England). 129: 515-24. PMID 15798027 DOI: 10.1530/rep.1.00576  0.331
2005 Bang S, Nagata S, Onda M, Kreitman RJ, Pastan I. HA22 (R490A) is a recombinant immunotoxin with increased antitumor activity without an increase in animal toxicity. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 1545-50. PMID 15746059 DOI: 10.1158/1078-0432.CCR-04-1939  0.305
2005 Ho M, Kreitman RJ, Onda M, Pastan I. In vitro antibody evolution targeting germline hot spots to increase activity of an anti-CD22 immunotoxin. The Journal of Biological Chemistry. 280: 607-17. PMID 15491997 DOI: 10.1074/jbc.M409783200  0.343
2004 Hassan R, Bera T, Pastan I. Mesothelin: a new target for immunotherapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 3937-42. PMID 15217923 DOI: 10.1158/1078-0432.CCR-03-0801  0.346
2004 Maeda H, Nagata S, Wolfgang CD, Bratthauer GL, Bera TK, Pastan I. The T cell receptor gamma chain alternate reading frame protein (TARP), a prostate-specific protein localized in mitochondria. The Journal of Biological Chemistry. 279: 24561-8. PMID 15150260 DOI: 10.1074/jbc.M402492200  0.335
2004 FitzGerald DJ, Kreitman R, Wilson W, Squires D, Pastan I. Recombinant immunotoxins for treating cancer. International Journal of Medical Microbiology : Ijmm. 293: 577-82. PMID 15149034 DOI: 10.1078/1438-4221-00302  0.399
2004 Yao Z, Zhang M, Garmestani K, Axworthy DB, Mallett RW, Fritzberg AR, Theodore LJ, Plascjak PS, Eckelman WC, Waldmann TA, Pastan I, Paik CH, Brechbiel MW, Carrasquillo JA. Pretargeted alpha emitting radioimmunotherapy using (213)Bi 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid-biotin. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 3137-46. PMID 15131055 DOI: 10.1158/1078-0432.Ccr-03-0171  0.301
2004 Oh S, Terabe M, Pendleton CD, Bhattacharyya A, Bera TK, Epel M, Reiter Y, Phillips J, Linehan WM, Kasten-Sportes C, Pastan I, Berzofsky JA. Human CTLs to wild-type and enhanced epitopes of a novel prostate and breast tumor-associated protein, TARP, lyse human breast cancer cells. Cancer Research. 64: 2610-8. PMID 15059918 DOI: 10.1158/0008-5472.Can-03-2183  0.326
2004 Onda M, Wang QC, Guo HF, Cheung NK, Pastan I. In vitro and in vivo cytotoxic activities of recombinant immunotoxin 8H9(Fv)-PE38 against breast cancer, osteosarcoma, and neuroblastoma. Cancer Research. 64: 1419-24. PMID 14973056 DOI: 10.1158/0008-5472.Can-03-0570  0.303
2004 Hassan R, Williams-Gould J, Watson T, Pai-Scherf L, Pastan I. Pretreatment with rituximab does not inhibit the human immune response against the immunogenic protein LMB-1. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 16-8. PMID 14734446 DOI: 10.1158/1078-0432.Ccr-1160-3  0.316
2004 Decker T, Oelsner M, Kreitman RJ, Salvatore G, Wang QC, Pastan I, Peschel C, Licht T. Induction of caspase-dependent programmed cell death in B-cell chronic lymphocytic leukemia by anti-CD22 immunotoxins. Blood. 103: 2718-26. PMID 14525789 DOI: 10.1182/blood-2003-04-1317  0.315
2004 Hassan R, Bullock S, Kreitman RJ, Kindler HL, Pastan I. Targeted therapy of mesothelin expressing mesotheliomas (MM), ovarian cancer (OC) and pancreatic cancer (PC): Results of phase I study of SS1(dsFv)PE38 (SS1P) Journal of Clinical Oncology. 22: 3035-3035. DOI: 10.1200/JCO.2004.22.90140.3035  0.303
2004 Decker T, Wagner M, Oelsner M, Kreitman RJ, Pastan I, Peschel C, Licht T. BL22, a Recombinant Anti-CD22 Immunotoxin, Induces Cell Cycle Arrest and Apoptosis in B-Cell Lymphoma. Blood. 104: 4613-4613. DOI: 10.1182/BLOOD.V104.11.4613.4613  0.363
2004 Ise T, Nagata S, Maeda H, Kreitman R, Stetler-Stevenson M, Pastan I. IRTA2 Protein on Lymphoma Cell Lines and Hairy Cell Leukemia Cells Detected by Novel Monoclonal Antibodies. Blood. 104: 1101-1101. DOI: 10.1182/BLOOD.V104.11.1101.1101  0.385
2003 Sampson JH, Akabani G, Archer GE, Bigner DD, Berger MS, Friedman AH, Friedman HS, Herndon JE, Kunwar S, Marcus S, McLendon RE, Paolino A, Penne K, Provenzale J, Quinn J, ... ... Pastan I, et al. Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malignant brain tumors. Journal of Neuro-Oncology. 65: 27-35. PMID 14649883 DOI: 10.1023/A:1026290315809  0.35
2003 Brinkmann U, Mansfield E, Pastan I. Effects of BCL-2 overexpression on the sensitivity of MCF-7 breast cancer cells to ricin, diphtheria and Pseudomonas toxin and immunotoxins. Apoptosis : An International Journal On Programmed Cell Death. 2: 192-8. PMID 14646554 DOI: 10.1023/A:1026468532413  0.341
2003 Gupta A, Onda M, Pastan I, Adhya S, Chaudhary VK. High-density functional display of proteins on bacteriophage lambda. Journal of Molecular Biology. 334: 241-54. PMID 14607116 DOI: 10.1016/J.Jmb.2003.09.033  0.312
2003 Nagata S, Salvatore G, Pastan I. DNA immunization followed by a single boost with cells: a protein-free immunization protocol for production of monoclonal antibodies against the native form of membrane proteins. Journal of Immunological Methods. 280: 59-72. PMID 12972188 DOI: 10.1016/S0022-1759(03)00192-3  0.362
2003 Cheng WS, Giandomenico V, Pastan I, Essand M. Characterization of the androgen-regulated prostate-specific T cell receptor gamma-chain alternate reading frame protein (TARP) promoter. Endocrinology. 144: 3433-40. PMID 12865322 DOI: 10.1210/en.2003-0121  0.301
2003 Pastan I. Immunotoxins containing Pseudomonas exotoxin A: a short history. Cancer Immunology, Immunotherapy : Cii. 52: 338-41. PMID 12700949 DOI: 10.1007/s00262-002-0353-8  0.396
2003 Kreitman RJ, Pastan I. Immunobiological treatments of hairy-cell leukaemia. Best Practice & Research. Clinical Haematology. 16: 117-33. PMID 12670470 DOI: 10.1016/S1521-6926(03)00003-3  0.318
2002 McHugh L, Hu S, Lee BK, Santora K, Kennedy PE, Berger EA, Pastan I, Hamer DH. Increased affinity and stability of an anti-HIV-1 envelope immunotoxin by structure-based mutagenesis. The Journal of Biological Chemistry. 277: 34383-90. PMID 12119300 DOI: 10.1074/jbc.M205456200  0.333
2002 Salvatore G, Nagata S, Billaud M, Santoro M, Vecchio G, Pastan I. Generation and characterization of novel monoclonal antibodies to the Ret receptor tyrosine kinase. Biochemical and Biophysical Research Communications. 294: 813-7. PMID 12061779 DOI: 10.1016/S0006-291X(02)00560-0  0.326
2002 Bera TK, Iavarone C, Kumar V, Lee S, Lee B, Pastan I. MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 99: 6997-7002. PMID 12011458 DOI: 10.1073/pnas.102187299  0.307
2002 Decker T, Hipp S, Kreitman RJ, Pastan I, Peschel C, Licht T. Sensitization of B-cell chronic lymphocytic leukemia cells to recombinant immunotoxin by immunostimulatory phosphorothioate oligodeoxynucleotides. Blood. 99: 1320-6. PMID 11830482 DOI: 10.1182/blood.V99.4.1320  0.332
2002 Shinohara H, Morita S, Kawai M, Miyamoto A, Sonoda T, Pastan I, Tanigawa N. Expression of HER2 in human gastric cancer cells directly correlates with antitumor activity of a recombinant disulfide-stabilized anti-HER2 immunotoxin. The Journal of Surgical Research. 102: 169-77. PMID 11796015 DOI: 10.1006/jsre.2001.6305  0.36
2001 Kobayashi T, Kida Y, Kaneko T, Pastan I, Kobayashi K. Efficient ablation by immunotoxin-mediated cell targeting of the cell types that express human interleukin-2 receptor depending on the internal ribosome entry site. The Journal of Gene Medicine. 3: 505-10. PMID 11601764 DOI: 10.1002/jgm.208  0.33
2001 Bera TK, Bera J, Brinkmann U, Tessarollo L, Pastan I. Cse1l is essential for early embryonic growth and development. Molecular and Cellular Biology. 21: 7020-4. PMID 11564884 DOI: 10.1128/MCB.21.20.7020-7024.2001  0.301
2001 Kreitman RJ, Wilson WH, Bergeron K, Raggio M, Stetler-Stevenson M, FitzGerald DJ, Pastan I. Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia. The New England Journal of Medicine. 345: 241-7. PMID 11474661 DOI: 10.1056/NEJM200107263450402  0.331
2001 Onda M, Olafsen T, Tsutsumi Y, Bruland ØS, Pastan I. Cytotoxicity of Antiosteosarcoma Recombinant Immunotoxins Composed of TP-3 Fv Fragments and a Truncated Pseudomonas Exotoxin A. Journal of Immunotherapy : Official Journal of the Society For Biological Therapy. 24: 144-150. PMID 11449071 DOI: 10.1097/00002371-200103000-00009  0.369
2001 Lee CG, Vieira WD, Pastan I, Gottesman MM. An episomally maintained MDR1 gene for gene therapy. Human Gene Therapy. 12: 945-53. PMID 11387059 DOI: 10.1089/104303401750195908  0.342
2001 Rozemuller H, Chowdhury PS, Pastan I, Kreitman RJ. Isolation of new anti-CD30 scFvs from DNA-immunized mice by phage display and biologic activity of recombinant immunotoxins produced by fusion with truncated pseudomonas exotoxin. International Journal of Cancer. Journal International Du Cancer. 92: 861-70. PMID 11351308 DOI: 10.1002/ijc.1266  0.305
2000 Kreitman RJ, Pastan I. 12 making fusion toxins to target leukemia and lymphoma. Methods in Molecular Medicine. 25: 215-26. PMID 21318848 DOI: 10.1385/1-59259-075-6:215  0.361
2000 Kuan CT, Wikstrand CJ, Archer G, Beers R, Pastan I, Zalutsky MR, Bigner DD. Increased binding affinity enhances targeting of glioma xenografts by EGFRvIII-specific scFv. International Journal of Cancer. Journal International Du Cancer. 88: 962-9. PMID 11093822 DOI: 10.1002/1097-0215(20001215)88:6<962::Aid-Ijc20>3.0.Co;2-U  0.317
2000 Wolfgang CD, Essand M, Vincent JJ, Lee B, Pastan I. TARP: a nuclear protein expressed in prostate and breast cancer cells derived from an alternate reading frame of the T cell receptor gamma chain locus. Proceedings of the National Academy of Sciences of the United States of America. 97: 9437-42. PMID 10931945 DOI: 10.1073/pnas.160270597  0.335
2000 Hassan R, Viner JL, Wang QC, Margulies I, Kreitman RJ, Pastan I. Anti-tumor activity of K1-LysPE38QQR, an immunotoxin targeting mesothelin, a cell-surface antigen overexpressed in ovarian cancer and malignant mesothelioma. Journal of Immunotherapy (Hagerstown, Md. : 1997). 23: 473-9. PMID 10916757 DOI: 10.1097/00002371-200007000-00011  0.363
2000 Tsutsumi Y, Onda M, Nagata S, Lee B, Kreitman RJ, Pastan I. Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity. Proceedings of the National Academy of Sciences of the United States of America. 97: 8548-53. PMID 10890891 DOI: 10.1073/pnas.140210597  0.335
2000 Keppler-Hafkemeyer A, Kreitman RJ, Pastan I. Apoptosis induced by immunotoxins used in the treatment of hematologic malignancies. International Journal of Cancer. Journal International Du Cancer. 87: 86-94. PMID 10861457 DOI: 10.1002/1097-0215(20000701)87:1<86::AID-IJC13>3.0.CO;2-I  0.342
2000 Booth CL, Pulaski L, Gottesman MM, Pastan I. Analysis of the properties of the N-terminal nucleotide-binding domain of human P-glycoprotein. Biochemistry. 39: 5518-26. PMID 10820025 DOI: 10.1021/Bi992931X  0.303
2000 Hafkemeyer P, Licht T, Pastan I, Gottesman MM. Chemoprotection of hematopoietic cells by a mutant P-glycoprotein resistant to a potent chemosensitizer of multidrug-resistant cancers. Human Gene Therapy. 11: 555-65. PMID 10724034 DOI: 10.1089/10430340050015743  0.319
2000 Shen DW, Goldenberg S, Pastan I, Gottesman MM. Decreased accumulation of [14C]carboplatin in human cisplatin-resistant cells results from reduced energy-dependent uptake. Journal of Cellular Physiology. 183: 108-16. PMID 10699972 DOI: 10.1002/(Sici)1097-4652(200004)183:1<108::Aid-Jcp13>3.0.Co;2-4  0.34
2000 Licht T, Goldenberg SK, Vieira WD, Gottesman MM, Pastan I. Drug selection of MDR1-transduced hematopoietic cells ex vivo increases transgene expression and chemoresistance in reconstituted bone marrow in mice. Gene Therapy. 7: 348-58. PMID 10694816 DOI: 10.1038/Sj.Gt.3301087  0.32
2000 Yerushalmi N, Brinkmann U, Brinkmann E, Pai L, Pastan I. Attenuating the growth of tumors by intratumoral administration of DNA encoding Pseudomonas exotoxin via cationic liposomes. Cancer Gene Therapy. 7: 91-6. PMID 10678361 DOI: 10.1038/sj.cgt.7700115  0.317
1999 Chowdhury PS, Pastan I. Analysis of cloned Fvs from a phage display library indicates that DNA immunization can mimic antibody response generated by cell immunizations. Journal of Immunological Methods. 231: 83-91. PMID 10648929 DOI: 10.1016/S0022-1759(99)00142-8  0.325
1999 Adobati E, Zacchetti A, Perico ME, Cremonesi F, Rasi G, Vallebona PS, Hagenaars M, Kuppen PJ, Pastan I, Panza L, Russo G, Colnaghi MI, Canevari S. Expression profile of saccharide epitope CaMBr1 in normal and neoplastic tissue from dogs, cats, and rats: implication for the development of human-derived cancer vaccines. The Histochemical Journal. 31: 729-37. PMID 10646838 DOI: 10.1023/A:1003900631953  0.307
1999 Kreitman RJ, Wilson WH, Robbins D, Margulies I, Stetler-Stevenson M, Waldmann TA, Pastan I. Responses in refractory hairy cell leukemia to a recombinant immunotoxin. Blood. 94: 3340-8. PMID 10552943 DOI: 10.1182/Blood.V94.10.3340.422K19_3340_3348  0.322
1999 Licht T, Aran JM, Goldenberg SK, Vieira WD, Gottesman MM, Pastan I. Retroviral transfer of human MDR1 gene to hematopoietic cells: effects of drug selection and of transcript splicing on expression of encoded P-glycoprotein. Human Gene Therapy. 10: 2173-85. PMID 10498249 DOI: 10.1089/10430349950017167  0.347
1999 Chowdhury PS, Pastan I. Improving antibody affinity by mimicking somatic hypermutation in vitro. Nature Biotechnology. 17: 568-72. PMID 10385321 DOI: 10.1038/9872  0.311
1999 Hafkemeyer P, Brinkmann U, Gottesman MM, Pastan I. Apoptosis induced by Pseudomonas exotoxin: a sensitive and rapid marker for gene delivery in vivo. Human Gene Therapy. 10: 923-34. PMID 10223726 DOI: 10.1089/10430349950018328  0.304
1999 Friedrich K, Wietek S, Lischke A, Wellbrock C, Kreitman RJ, Pastan I, Sebald W. A two-step selection approach for the identification of ligand-binding determinants in cytokine receptors Analytical Biochemistry. 268: 179-186. PMID 10075806 DOI: 10.1006/abio.1998.3078  0.324
1999 Hassan R, Wu C, Brechbiel MW, Margulies I, Kreitman RJ, Pastan I. 111Indium-labeled monoclonal antibody K1: Biodistribution study in nude mice bearing a human carcinoma xenograft expressing mesothelin International Journal of Cancer. 80: 559-563. PMID 9935157 DOI: 10.1002/(SICI)1097-0215(19990209)80:4<559::AID-IJC13>3.0.CO;2-Y  0.309
1999 Reiter Y, Pastan I. Recombinant Fv immunotoxins and Fv fragments as novel agents for cancer therapy and diagnosis. Trends in Biotechnology. 16: 513-20. PMID 9881483 DOI: 10.1016/S0167-7799(98)01226-8  0.336
1999 Moscow JA, Huang H, Carter C, Hines K, Zujewski J, Cusack G, Chow C, Venzon D, Sorrentino B, Chiang Y, Goldspiel B, Leitman S, Read EJ, Abati A, Gottesman MM, ... Pastan I, et al. Engraftment of MDR1 and NeoR Gene-Transduced Hematopoietic Cells After Breast Cancer Chemotherapy Blood. 94: 52-61. DOI: 10.1182/Blood.V94.1.52.413K35_52_61  0.314
1998 PASTAN I. Certain functions of isolated thyroid cells. Endocrinology. 68: 924-31. PMID 13733193 DOI: 10.1210/ENDO-68-6-924  0.304
1998 Pastan I, Kreitman RJ. Immunotoxins for targeted cancer therapy. Advanced Drug Delivery Reviews. 31: 53-88. PMID 10837618 DOI: 10.1016/S0169-409X(97)00094-X  0.364
1998 Bera TK, Pastan I. Comparison of recombinant immunotoxins against LeY antigen expressing tumor cells: influence of affinity, size, and stability. Bioconjugate Chemistry. 9: 736-43. PMID 9815167 DOI: 10.1021/bc980028o  0.348
1998 Hrycyna CA, Airan LE, Germann UA, Ambudkar SV, Pastan I, Gottesman MM. Structural flexibility of the linker region of human P-glycoprotein permits ATP hydrolysis and drug transport. Biochemistry. 37: 13660-73. PMID 9753453 DOI: 10.1021/Bi9808823  0.336
1998 Lee CG, Pastan I, Gottesman MM. Retroviral transfer of human MDR1 gene into human T lymphocytes. Methods in Enzymology. 292: 557-72. PMID 9711583 DOI: 10.1016/S0076-6879(98)92044-4  0.357
1998 Licht T, Gottesman MM, Pastan I. Retroviral transfer of multidrug transporter to murine hematopoietic stem cells. Methods in Enzymology. 292: 546-57. PMID 9711582 DOI: 10.1016/S0076-6879(98)92043-2  0.313
1998 Sugimoto Y, Gottesman MM, Pastan I, Tsuruo T. Construction of MDR1 vectors for gene therapy. Methods in Enzymology. 292: 523-37. PMID 9711580 DOI: 10.1016/S0076-6879(98)92041-9  0.313
1998 Zhang S, Sugimoto Y, Shoshani T, Pastan I, Gottesman MM. pHaMDR-DHFR bicistronic expression system for mutational analysis of P-glycoprotein. Methods in Enzymology. 292: 474-80. PMID 9711575 DOI: 10.1016/S0076-6879(98)92036-5  0.313
1998 Hrycyna CA, Ramachandra M, Pastan I, Gottesman MM. Functional expression of human P-glycoprotein from plasmids using vaccinia virus-bacteriophage T7 RNA polymerase system. Methods in Enzymology. 292: 456-73. PMID 9711574 DOI: 10.1016/S0076-6879(98)92035-3  0.328
1998 Ramachandra M, Gottesman MM, Pastan I. Recombinant vaccinia virus vectors for functional expression of P-glycoprotein in mammalian cells. Methods in Enzymology. 292: 441-55. PMID 9711573 DOI: 10.1016/S0076-6879(98)92034-1  0.326
1998 Dey S, Ramachandra M, Pastan I, Gottesman MM, Ambudkar SV. Photoaffinity labeling of human P-glycoprotein: effect of modulator interaction and ATP hydrolysis on substrate binding. Methods in Enzymology. 292: 318-28. PMID 9711564 DOI: 10.1016/S0076-6879(98)92025-0  0.313
1998 Bera TK, Onda M, Brinkmann U, Pastan I. A bivalent disulfide-stabilized Fv with improved antigen binding to erbB2. Journal of Molecular Biology. 281: 475-83. PMID 9698563 DOI: 10.1006/jmbi.1998.1948  0.305
1998 Kobayashi H, Han ES, Kim IS, Le N, Rajagopal V, Kreitman RJ, Pastan I, Paik CH, Carrasquillo JA. Similarities in the biodistribution of iodine-labeled anti-Tac single-chain disulfide-stabilized Fv fragment and anti-Tac disulfide-stabilized Fv fragment. Nuclear Medicine and Biology. 25: 387-93. PMID 9639301 DOI: 10.1016/S0969-8051(97)00228-X  0.318
1998 Reiter Y, Brinkmann U, Lee B, Pastan I. Engineering antibody Fv fragments for cancer detection and therapy: disulfide-stabilized Fv fragments. Nature Biotechnology. 14: 1239-45. PMID 9631086 DOI: 10.1038/NBT1096-1239  0.313
1998 Almog O, Benhar I, Vasmatzis G, Tordova M, Lee B, Pastan I, Gilliland GL. Crystal structure of the disulfide-stabilized Fv fragment of anticancer antibody B1: conformational influence of an engineered disulfide bond. Proteins. 31: 128-38. PMID 9593187 DOI: 10.1002/(Sici)1097-0134(19980501)31:2<128::Aid-Prot3>3.0.Co;2-I  0.579
1998 Zhou Y, Aran J, Gottesman MM, Pastan I. Co-expression of human adenosine deaminase and multidrug resistance using a bicistronic retroviral vector. Human Gene Therapy. 9: 287-93. PMID 9508046 DOI: 10.1089/Hum.1998.9.3-287  0.314
1998 Sawada H, Nishii K, Suzuki T, Hasegawa K, Hata T, Nagatsu I, Kreitman RJ, Pastan I, Nagatsu T, Kobayashi K. Autonomic neuropathy in transgenic mice caused by immunotoxin targeting of the peripheral nervous system Journal of Neuroscience Research. 51: 162-173. PMID 9469570 DOI: 10.1002/(SICI)1097-4547(19980115)51:2<162::AID-JNR5>3.0.CO;2-B  0.314
1998 Chowdhury PS, Viner JL, Beers R, Pastan I. Isolation of a high-affinity stable single-chain Fv specific for mesothelin from DNA-immunized mice by phage display and construction of a recombinant immunotoxin with anti-tumor activity. Proceedings of the National Academy of Sciences of the United States of America. 95: 669-74. PMID 9435250 DOI: 10.1073/Pnas.95.2.669  0.378
1997 Rajagopal V, Pastan I, Kreitman RJ. A form of anti-Tac(Fv) which is both single-chain and disulfide stabilized: comparison with its single-chain and disulfide-stabilized homologs. Protein Engineering. 10: 1453-9. PMID 9543007 DOI: 10.1093/PROTEIN/10.12.1453  0.314
1997 Lee CG, Jeang KT, Martin MA, Pastan I, Gottesman MM. Efficient long-term coexpression of a hammerhead ribozyme targeted to the U5 region of HIV-1 LTR by linkage to the multidrug-resistance gene. Antisense & Nucleic Acid Drug Development. 7: 511-22. PMID 9361910 DOI: 10.1089/Oli.1.1997.7.511  0.314
1997 Rozemuller H, Rombouts EJC, Touw IP, Fitzgerald DJP, Kreitman RJ, Pastan I, Hagenbeek A, Martens ACM. Sensitivity of human acute myeloid leukaemia to diphtheria toxin-GM-CSF fusion protein British Journal of Haematology. 98: 952-959. PMID 9326195 DOI: 10.1046/J.1365-2141.1997.2893106.X  0.317
1997 Funatomi H, Itakura J, Ishiwata T, Pastan I, Thompson SA, Johnson GR, Korc M. Amphiregulin antisense oligonucleotide inhibits the growth of T3M4 human pancreatic cancer cells and sensitizes the cells to EGF receptor-targeted therapy. International Journal of Cancer. 72: 512-7. PMID 9247297 DOI: 10.1002/(Sici)1097-0215(19970729)72:3<512::Aid-Ijc21>3.0.Co;2-C  0.345
1997 Chowdhury PS, Chang K, Pastan I. Isolation of anti-mesothelin antibodies from a phage display library. Molecular Immunology. 34: 9-20. PMID 9182872 DOI: 10.1016/S0161-5890(97)00011-4  0.342
1997 Brinkmann U, Webber K, Di Carlo A, Beers R, Chowdhury P, Chang K, Chaudhary V, Gallo M, Pastan I. Cloning and expression of the recombinant FAb fragment of monoclonal antibody K1 that reacts with mesothelin present on mesotheliomas and ovarian cancers. International Journal of Cancer. 71: 638-44. PMID 9178820 DOI: 10.1002/(SICI)1097-0215(19970516)71:4<638::AID-IJC21>3.0.CO;2-6  0.308
1997 Reiter Y, Di Carlo A, Fugger L, Engberg J, Pastan I. Peptide-specific killing of antigen-presenting cells by a recombinant antibody-toxin fusion protein targeted to major histocompatibility complex/peptide class I complexes with T cell receptor-like specificity. Proceedings of the National Academy of Sciences of the United States of America. 94: 4631-6. PMID 9114042 DOI: 10.1073/PNAS.94.9.4631  0.332
1997 Licht T, Herrmann F, Gottesman MM, Pastan I. In vivo drug-selectable genes: a new concept in gene therapy. Stem Cells (Dayton, Ohio). 15: 104-11. PMID 9090786 DOI: 10.1002/Stem.150104  0.318
1997 Aran JM, Licht T, Gottesman MM, Pastan I. Complete restoration of glucocerebrosidase deficiency in Gaucher fibroblasts using a bicistronic MDR retrovirus and a new selection strategy. Human Gene Therapy. 7: 2165-75. PMID 8934230 DOI: 10.1089/Hum.1996.7.17-2165  0.315
1997 Mansfield E, Amlot P, Pastan I, FitzGerald DJ. Recombinant RFB4 Immunotoxins Exhibit Potent Cytotoxic Activity for CD22-Bearing Cells and Tumors Blood. 90: 2020-2026. DOI: 10.1182/Blood.V90.5.2020  0.319
1997 Kreitman RJ, Pastan I. Recombinant Toxins Containing Human Granulocyte-Macrophage Colony-Stimulating Factor and Either Pseudomonas Exotoxin or Diphtheria Toxin Kill Gastrointestinal Cancer and Leukemia Cells Blood. 90: 252-259. DOI: 10.1182/blood.v90.1.252  0.367
1996 Lorimer IA, Keppler-Hafkemeyer A, Beers RA, Pegram CN, Bigner DD, Pastan I. Recombinant immunotoxins specific for a mutant epidermal growth factor receptor: targeting with a single chain antibody variable domain isolated by phage display. Proceedings of the National Academy of Sciences of the United States of America. 93: 14815-20. PMID 8962138 DOI: 10.1073/pnas.93.25.14815  0.357
1996 Ramachandra M, Ambudkar SV, Gottesman MM, Pastan I, Hrycyna CA. Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system. Molecular Biology of the Cell. 7: 1485-98. PMID 8898356 DOI: 10.1091/Mbc.7.10.1485  0.338
1996 Mansfield E, Pastan I, FitzGerald DJ. Characterization of RFB4-Pseudomonas exotoxin A immunotoxins targeted to CD22 on B-cell malignancies Bioconjugate Chemistry. 7: 557-563. PMID 8889017 DOI: 10.1021/bc960043y  0.359
1996 Kobayashi K, Ohye T, Pastan I, Nagatsu T. A novel strategy for the negative selection in mouse embryonic stem cells operated with immunotoxin-mediated cell targeting. Nucleic Acids Research. 24: 3653-5. PMID 8836200 DOI: 10.1093/NAR/24.18.3653  0.355
1996 Baudard M, Flotte TR, Aran JM, Thierry AR, Pastan I, Pang MG, Kearns WG, Gottesman MM. Expression of the human multidrug resistance and glucocerebrosidase cDNAs from adeno-associated vectors: efficient promoter activity of AAV sequences and in vivo delivery via liposomes. Human Gene Therapy. 7: 1309-22. PMID 8818718 DOI: 10.1089/Hum.1996.7.11-1309  0.34
1996 Baldwin RL, Kobrin MS, Tran T, Pastan I, Korc M. Cytotoxic effects of TGF-α-Pseudomonas exotoxin A fusion protein in human pancreatic carcinoma cells Pancreas. 13: 16-21. PMID 8783329 DOI: 10.1097/00006676-199607000-00002  0.353
1996 Aksentijevich I, Pastan I, Lunardi-Iskandar Y, Gallo RC, Gottesman MM, Thierry AR. In vitro and in vivo liposome-mediated gene transfer leads to human MDR1 expression in mouse bone marrow progenitor cells. Human Gene Therapy. 7: 1111-22. PMID 8773513 DOI: 10.1089/Hum.1996.7.9-1111  0.317
1996 Prior TI, Kunwar S, Pastan I. Studies on the activity of barnase toxins in vitro and in vivo. Bioconjugate Chemistry. 7: 23-9. PMID 8741987 DOI: 10.1021/bc9500655  0.318
1996 Li M, Dyda F, Benhar I, Pastan I, Davies DR. Crystal structure of the catalytic domain of Pseudomonas exotoxin A complexed with a nicotinamide adenine dinucleotide analog: implications for the activation process and for ADP ribosylation. Proceedings of the National Academy of Sciences of the United States of America. 93: 6902-6. PMID 8692916 DOI: 10.1073/Pnas.93.14.6902  0.564
1996 Reiter Y, Wright AF, Tonge DW, Pastan I. Recombinant single-chain and disulfide-stabilized Fv-immunotoxins that cause complete regression of a human colon cancer xenograft in nude mice. International Journal of Cancer. 67: 113-23. PMID 8690511 DOI: 10.1002/(SICI)1097-0215(19960703)67:1<113::AID-IJC19>3.0.CO;2-F  0.348
1996 Johnson SW, Shen DW, Pastan I, Gottesman MM, Hamilton TC. Cross-resistance, cisplatin accumulation, and platinum-DNA adduct formation and removal in cisplatin-sensitive and -resistant human hepatoma cell lines Experimental Cell Research. 226: 133-139. PMID 8660948 DOI: 10.1006/Excr.1996.0211  0.312
1996 Kuan CT, Pastan I. Improved antitumor activity of a recombinant anti-Lewisy immunotoxin not requiring proteolytic activation Proceedings of the National Academy of Sciences of the United States of America. 93: 974-978. PMID 8577771 DOI: 10.1073/PNAS.93.3.974  0.332
1996 Germann UA, Chambers TC, Ambudkar SV, Licht T, Cardarelli CO, Pastan I, Gottesman MM. Characterization of phosphorylation-defective mutants of human P-glycoprotein expressed in mammalian cells. The Journal of Biological Chemistry. 271: 1708-16. PMID 8576173 DOI: 10.1074/Jbc.271.3.1708  0.313
1996 Chang K, Pastan I. Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. Proceedings of the National Academy of Sciences of the United States of America. 93: 136-140. PMID 8552591 DOI: 10.1073/Pnas.93.1.136  0.358
1996 Fitzgerald D, Pastan I. Recombinant immunotoxins for the treatment of cancer Journal of Controlled Release. 39: 261-265. DOI: 10.1016/0168-3659(95)00200-6  0.349
1995 Kreitman RJ, Pastan I. Targeting Pseudomonas exotoxin to hematologic malignancies Seminars in Cancer Biology. 6: 297-306. PMID 8562907 DOI: 10.1006/SCBI.1995.0038  0.377
1995 Benhar I, Padlan EA, Jung SH, Lee B, Pastan I. Rapid humanization of the Fv of monoclonal antibody B3 by using framework exchange of the recombinant immunotoxin B3(Fv)-PE38. Proceedings of the National Academy of Sciences of the United States of America. 91: 12051-5. PMID 7991583 DOI: 10.1073/Pnas.91.25.12051  0.574
1995 Brinkmann U, Chowdhury PS, Roscoe DM, Pastan I. Phage display of disulfide-stabilized Fv fragments. Journal of Immunological Methods. 182: 41-50. PMID 7769243 DOI: 10.1016/0022-1759(95)00016-4  0.331
1995 Campain JA, Gottesman MM, Pastan I. A novel mutant topoisomerase II alpha present in VP-16-resistant human melanoma cell lines has a deletion of alanine 429. Biochemistry. 33: 11327-32. PMID 7727383 DOI: 10.1021/Bi00203A030  0.325
1995 Webber KO, Reiter Y, Brinkmann U, Kreitman R, Pastan I. Preparation and characterization of a disulfide-stabilized Fv fragment of the anti-Tac antibody: Comparison with its single-chain analog Molecular Immunology. 32: 249-258. PMID 7723770 DOI: 10.1016/0161-5890(94)00150-Y  0.318
1995 Benhar I, Pastan I. Cloning, expression and characterization of the Fv fragments of the anti-carbohydrate mAbs B1 and B5 as single-chain immunotoxins. Protein Engineering. 7: 1509-15. PMID 7716163 DOI: 10.1093/Protein/7.12.1509  0.593
1995 Shen DW, Akiyama S, Schoenlein P, Pastan I, Gottesman MM. Characterisation of high-level cisplatin-resistant cell lines established from a human hepatoma cell line and human KB adenocarcinoma cells: cross-resistance and protein changes. British Journal of Cancer. 71: 676-83. PMID 7710928 DOI: 10.1038/Bjc.1995.134  0.363
1995 Reiter Y, Kurucz I, Brinkmann U, Jung SH, Lee B, Segal DM, Pastan I. Construction of a functional disulfide-stabilized TCR Fv indicates that antibody and TCR Fv frameworks are very similar in structure. Immunity. 2: 281-7. PMID 7697545 DOI: 10.1016/1074-7613(95)90052-7  0.306
1995 Evans GL, Ni B, Hrycyna CA, Chen D, Ambudkar SV, Pastan I, Germann UA, Gottesman MM. Heterologous expression systems for P-glycoprotein: E. coli, yeast, and baculovirus. Journal of Bioenergetics and Biomembranes. 27: 43-52. PMID 7629051 DOI: 10.1007/Bf02110330  0.308
1995 Benhar I, Reiter Y, Pai LH, Pastan I. Administration of disulfide-stabilized Fv-immunotoxins B1(dsFv)-PE38 and B3(dsFv)-PE38 by continuous infusion increases their efficacy in curing large tumor xenografts in nude mice. International Journal of Cancer. 62: 351-5. PMID 7628878 DOI: 10.1002/Ijc.2910620320  0.568
1995 Debinski W, Obiri NI, Pastan I, Puri RK. A novel chimeric protein composed of interleukin 13 and Pseudomonas exotoxin is highly cytotoxic to human carcinoma cells expressing receptors for interleukin 13 and interleukin 4 Journal of Biological Chemistry. 270: 16775-16780. PMID 7622490 DOI: 10.1074/jbc.270.28.16775  0.364
1995 Li M, Dyda F, Benhar I, Pastan I, Davies DR. The crystal structure of Pseudomonas aeruginosa exotoxin domain III with nicotinamide and AMP: conformational differences with the intact exotoxin. Proceedings of the National Academy of Sciences of the United States of America. 92: 9308-12. PMID 7568123 DOI: 10.1073/Pnas.92.20.9308  0.561
1995 Benhar I, Pastan I. Identification of residues that stabilize the single-chain Fv of monoclonal antibodies B3. The Journal of Biological Chemistry. 270: 23373-80. PMID 7559495 DOI: 10.1074/Jbc.270.40.23373  0.585
1995 Brinkmann U, Brinkmann E, Gallo M, Pastan I. Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1. Proceedings of the National Academy of Sciences of the United States of America. 92: 10427-31. PMID 7479798 DOI: 10.1073/PNAS.92.22.10427  0.341
1995 Licht T, Aksentijevich I, Gottesman M, Pastan I. Efficient expression of functional human MDR1 gene in murine bone marrow after retroviral transduction of purified hematopoietic stem cells Blood. 86: 111-121. DOI: 10.1182/blood.V86.1.111.bloodjournal861111  0.326
1995 Brinkmann U, Brinkmann E, Pastan I. Expression Cloning of cDNAs That Render Cancer Cells Resistant to Pseudomonas and Diphtheria Toxin and Immunotoxins Molecular Medicine. 1: 206-216. DOI: 10.1007/BF03401568  0.365
1995 Brinkmann U, Pastan I. Recombinant Immunotoxins: From Basic Research to Cancer Therapy Methods. 8: 143-156. DOI: 10.1006/METH.1995.9992  0.319
1994 Draoui M, Siegall CB, FitzGerald D, Pastan I, Moody TW. TGFα-PE40 inhibits non-small cell lung cancer growth Life Sciences. 54: 445-453. PMID 8309347 DOI: 10.1016/0024-3205(94)00403-X  0.305
1994 Kreitman RJ, Pastan I. Purification and characterization of IL6-PE4E, a recombinant fusion of interleukin 6 with Pseudomonas exotoxin. Bioconjugate Chemistry. 4: 581-5. PMID 8305530 DOI: 10.1021/BC00024A025  0.304
1994 Fu YM, Mesri EA, Yu ZX, Kreitman RJ, Pastan I, Epstein SE. Cytotoxic effects of vascular smooth muscle cells of the chimeric toxin, heparin binding TGF alpha-Pseudomonas exotoxin. Cardiovascular Research. 27: 1691-7. PMID 8287449 DOI: 10.1093/cvr/27.9.1691  0.308
1994 Kreitman RJ, Chang CN, Hudson DV, Queen C, Bailon P, Pastan I. Anti-Tac(Fab)-PE40, a recombinant double-chain immunotoxin which kills interleukin-2-receptor-bearing cells and induces complete remission in an in vivo tumor model. International Journal of Cancer. 57: 856-64. PMID 8206679 DOI: 10.1002/IJC.2910570615  0.355
1994 Debinski W, Pastan I. An immunotoxin with increased activity and homogeneity produced by reducing the number of lysine residues in recombinant Pseudomonas exotoxin Bioconjugate Chemistry. 5: 40-46. PMID 8199233 DOI: 10.1021/Bc00025A006  0.317
1994 Chang K, Pastan I. Molecular cloning and expression of a cDNA encoding a protein detected by the K1 antibody from an ovarian carcinoma (OVCAR-3) cell line. International Journal of Cancer. 57: 90-7. PMID 8150545 DOI: 10.1002/IJC.2910570117  0.372
1994 Puri RK, Debinski W, Obiri N, Kreitman R, Pastan I. Human Renal Cell Carcinoma Cells Are Sensitive to the Cytotoxic Effect of a Chimeric Protein Composed of Human Interleukin-4 and Pseudomonas Exotoxin Cellular Immunology. 154: 369-379. PMID 8131209 DOI: 10.1006/cimm.1994.1084  0.342
1994 Debinski W, Puri RK, Pastan I. Interleukin-4 receptors expressed on tumor cells may serve as a target for anticancer therapy using chimeric Pseudomonas exotoxin International Journal of Cancer. 58: 744-748. PMID 8077061 DOI: 10.1002/Ijc.2910580520  0.314
1994 Reiter Y, Brinkmann U, Webber KO, Jung SH, Lee B, Pastan I. Engineering interchain disulfide bonds into conserved framework regions of Fv fragments: improved biochemical characteristics of recombinant immunotoxins containing disulfide-stabilized Fv. Protein Engineering. 7: 697-704. PMID 8073039 DOI: 10.1093/PROTEIN/7.5.697  0.311
1994 Jung SH, Pastan I, Lee B. Design of interchain disulfide bonds in the framework region of the Fv fragment of the monoclonal antibody B3. Proteins. 19: 35-47. PMID 8066084 DOI: 10.1002/PROT.340190106  0.324
1994 Kameyama S, Kawamata H, Pastan I, Oyasu R. Cytotoxic effect of a fusion protein from transforming growth factor a and Pseudomonas exotoxin on rat and human bladder carcinoma cells in vitro Journal of Cancer Research and Clinical Oncology. 120: 507-512. PMID 8045915 DOI: 10.1007/Bf01221026  0.325
1994 Reiter Y, Kreitman RJ, Brinkmann U, Pastan I. Cytotoxic and antitumor activity of a recombinant immunotoxin composed of disulfide-stabilized anti-Tac Fv fragment and truncated Pseudomonas exotoxin. International Journal of Cancer. 58: 142-9. PMID 8014011 DOI: 10.1002/IJC.2910580123  0.341
1994 Licht T, Pastan I, Gottesman M, Herrmann F. P-glycoprotein-mediated multidrug resistance in normal and neoplastic hematopoietic cells. Annals of Hematology. 69: 159-71. PMID 7948302 DOI: 10.1007/Bf02215949  0.311
1994 Benhar I, Brinkmann U, Webber KO, Pastan I. Mutations of two lysine residues in the CDR loops of a recombinant immunotoxin that reduce its sensitivity to chemical derivatization. Bioconjugate Chemistry. 5: 321-326. PMID 7948099 DOI: 10.1021/Bc00028A007  0.576
1994 Roscoe DM, Jung SH, Benhar I, Pai L, Lee BK, Pastan I. Primate antibody response to immunotoxin: serological and computer-aided analysis of epitopes on a truncated form of Pseudomonas exotoxin. Infection and Immunity. 62: 5055-65. PMID 7927788 DOI: 10.1128/Iai.62.11.5055-5065.1994  0.574
1994 Gottesman MM, Germann UA, Aksentijevich I, Sugimoto Y, Cardarelli CO, Pastan I. Gene transfer of drug resistance genes. Implications for cancer therapy. Annals of the New York Academy of Sciences. 716: 126-38; discussion 1. PMID 7912913 DOI: 10.1111/J.1749-6632.1994.Tb21708.X  0.318
1994 Reiter Y, Brinkmann U, Kreitman RJ, Jung SH, Lee B, Pastan I. Stabilization of the Fv fragments in recombinant immunotoxins by disulfide bonds engineered into conserved framework regions. Biochemistry. 33: 5451-9. PMID 7910034 DOI: 10.1021/BI00184A014  0.304
1994 Aran JM, Gottesman MM, Pastan I. Drug-selected coexpression of human glucocerebrosidase and P-glycoprotein using a bicistronic vector. Proceedings of the National Academy of Sciences of the United States of America. 91: 3176-80. PMID 7909160 DOI: 10.1073/pnas.91.8.3176  0.337
1994 Siegsmund MJ, Cardarelli C, Aksentijevich I, Sugimoto Y, Pastan I, Gottesman MM. Ketoconazole effectively reverses multidrug resistance in highly resistant KB cells. The Journal of Urology. 151: 485-91. PMID 7904313 DOI: 10.1016/S0022-5347(17)34999-6  0.307
1994 Siegall CB, Gawlak SL, Chace DF, Merwin JR, Pastan I. In vivo activities of acidic fibroblast growth factor-Pseudomonas exotoxin fusion proteins. Bioconjugate Chemistry. 5: 77-83. PMID 7515280 DOI: 10.1021/bc00025a010  0.359
1994 Gawlak SL, Pastan I, Siegall CB. Basic fibroblast growth factor-Pseudomonas exotoxin chimeric proteins; comparison with acidic fibroblast growth factor-Pseudomonas exotoxin. Bioconjugate Chemistry. 4: 483-9. PMID 7508267 DOI: 10.1021/BC00024A010  0.356
1994 Kreitman R, Bailon P, Chaudhary V, FitzGerald D, Pastan I. Recombinant immunotoxins containing anti-Tac(Fv) and derivatives of Pseudomonas exotoxin produce complete regression in mice of an interleukin-2 receptor-expressing human carcinoma Blood. 83: 426-434. DOI: 10.1182/blood.v83.2.426.426  0.365
1993 Jhappan C, Stahle C, Wolff M, Merlino G, Pastan I. An epidermal growth factor receptor promoter construct selectively expresses in the thymus and spleen of transgenic mice. Cellular Immunology. 149: 99-106. PMID 8513514 DOI: 10.1006/CIMM.1993.1139  0.331
1993 Theuer CP, FitzGerald DJ, Pastan I. A recombinant form of Pseudomonas exotoxin A containing transforming growth factor alpha near its carboxyl terminus for the treatment of bladder cancer. The Journal of Urology. 149: 1626-32. PMID 8501821 DOI: 10.1016/S0022-5347(17)36464-9  0.316
1993 Spence C, Nachman M, Gately MK, Kreitman RJ, Pastan I, Bailon P. Affinity purification and characterization of anti-Tac(Fv)-C3-PE38KDEL: A highly potent cytotoxic agent specific to cells bearing IL-2 receptors Bioconjugate Chemistry. 4: 63-68. PMID 8431514 DOI: 10.1021/BC00019A009  0.34
1993 Brinkmann U, Gallo M, Brinkmann E, Kunwar S, Pastan I. A recombinant immunotoxin that is active on prostate cancer cells and that is composed of the Fv region of monoclonal antibody PR1 and a truncated form of Pseudomonas exotoxin. Proceedings of the National Academy of Sciences of the United States of America. 90: 547-51. PMID 8421689 DOI: 10.1073/PNAS.90.2.547  0.335
1993 Mickisch GH, Pai LH, Siegsmund M, Campain J, Gottesman MM, Pastan I. Pseudomonas exotoxin conjugated to monoclonal antibody MRK16 specifically kills multidrug resistant cells in cultured renal carcinomas and in MDR-transgenic mice. The Journal of Urology. 149: 174-8. PMID 8417204 DOI: 10.1016/S0022-5347(17)36033-0  0.335
1993 Theuer CP, Pastan I. Immunotoxins and recombinant toxins in the treatment of solid carcinomas. American Journal of Surgery. 166: 284-8. PMID 8368439 DOI: 10.1016/S0002-9610(05)80975-4  0.371
1993 Fitzgerald D, Pastan I. Pseudomonas exotoxin and recombinant immunotoxins derived from it. Annals of the New York Academy of Sciences. 685: 740-5. PMID 8363279 DOI: 10.1111/j.1749-6632.1993.tb35935.x  0.378
1993 Campain JA, Padmanabhan R, Hwang J, Gottesman MM, Pastan I. Characterization of an unusual mutant of human melanoma cells resistant to anticancer drugs that inhibit topoisomerase II. Journal of Cellular Physiology. 155: 414-25. PMID 8097746 DOI: 10.1002/Jcp.1041550224  0.321
1993 Kreitman RJ, Batra JK, Seetharam S, Chaudhary VK, FitzGerald DJ, Pastan I. Single-chain immunotoxin fusions between anti-Tac and Pseudomonas exotoxin: relative importance of the two toxin disulfide bonds. Bioconjugate Chemistry. 4: 112-20. PMID 7873642 DOI: 10.1021/bc00020a002  0.306
1993 Kunwar S, Pai LH, Pastan I. Cytotoxicity and antitumor effects of growth factor-toxin fusion proteins on human glioblastoma multiforme cells. Journal of Neurosurgery. 79: 569-76. PMID 7692018 DOI: 10.3171/jns.1993.79.4.0569  0.356
1993 Hoess R, Brinkmann U, Handel T, Pastan I. Identification of a peptide which binds to the carbohydrate-specific monoclonal antibody B3. Gene. 128: 43-9. PMID 7685300 DOI: 10.1016/0378-1119(93)90151-R  0.301
1993 FitzGerald DJ, Pastan I. Pseudomonas exotoxin: recombinant conjugates as therapeutic agents. Biochemical Society Transactions. 20: 731-4. PMID 1487051 DOI: 10.1042/BST0200731  0.326
1992 Chang K, Pastan I, Willingham MC. Isolation and characterization of a monoclonal antibody, K1, reactive with ovarian cancers and normal mesothelium. International Journal of Cancer. 50: 373-81. PMID 1735605 DOI: 10.1002/IJC.2910500308  0.328
1992 Kreitman RJ, Siegall CB, Chaudhary VK, FitzGerald DJ, Pastan I. Properties of chimeric toxins with two recognition domains: interleukin 6 and transforming growth factor alpha at different locations in Pseudomonas exotoxin. Bioconjugate Chemistry. 3: 63-8. PMID 1616951 DOI: 10.1021/bc00013a010  0.32
1992 Schoenlein PV, Shen DW, Barrett JT, Pastan I, Gottesman MM. Double minute chromosomes carrying the human multidrug resistance 1 and 2 genes are generated from the dimerization of submicroscopic circular DNAs in colchicine-selected KB carcinoma cells. Molecular Biology of the Cell. 3: 507-20. PMID 1611154 DOI: 10.1091/Mbc.3.5.507  0.306
1992 Brinkmann U, Pai LH, FitzGerald DJ, Pastan I. Alteration of a protease-sensitive region of Pseudomonas exotoxin prolongs its survival in the circulation of mice. Proceedings of the National Academy of Sciences of the United States of America. 89: 3065-9. PMID 1557414 DOI: 10.1073/PNAS.89.7.3065  0.323
1992 Batra JK, Kasprzyk PG, Bird RE, Pastan I, King CR. Recombinant anti-erbB2 immunotoxins containing Pseudomonas exotoxin. Proceedings of the National Academy of Sciences of the United States of America. 89: 5867-71. PMID 1352878 DOI: 10.1073/Pnas.89.13.5867  0.367
1992 Sorrentino BP, Brandt SJ, Bodine D, Gottesman M, Pastan I, Cline A, Nienhuis AW. Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1 Science. 257: 99-103. PMID 1352414 DOI: 10.1126/Science.1352414  0.304
1992 Chin KV, Chauhan SS, Abraham I, Sampson KE, Krolczyk AJ, Wong M, Schimmer B, Pastan I, Gottesman MM. Reduced mRNA levels for the multidrug-resistance genes in cAMP-dependent protein kinase mutant cell lines. Journal of Cellular Physiology. 152: 87-94. PMID 1352302 DOI: 10.1002/Jcp.1041520112  0.349
1992 Buchner J, Pastan I, Brinkmann U. A method for increasing the yield of properly folded recombinant fusion proteins: single-chain immunotoxins from renaturation of bacterial inclusion bodies. Analytical Biochemistry. 205: 263-70. PMID 1332541 DOI: 10.1016/0003-2697(92)90433-8  0.326
1992 Biro S, Siegall CB, Fu YM, Speir E, Pastan I, Epstein SE. In vitro effects of a recombinant toxin targeted to the fibroblast growth factor receptor on rat vascular smooth muscle and endothelial cells. Circulation Research. 71: 640-5. PMID 1323436 DOI: 10.1161/01.RES.71.3.640  0.321
1992 Kreitman RJ, FitzGerald D, Pastan I. Targeting growth factor receptors with fusion toxins. International Journal of Immunopharmacology. 14: 465-72. PMID 1319965 DOI: 10.1016/0192-0561(92)90177-M  0.372
1992 Kreitman R, Chaudhary V, Kozak R, FitzGerald D, Waldman T, Pastan I. Recombinant toxins containing the variable domains of the anti-Tac monoclonal antibody to the interleukin-2 receptor kill malignant cells from patients with chronic lymphocytic leukemia Blood. 80: 2344-2352. DOI: 10.1182/BLOOD.V80.9.2344.BLOODJOURNAL8092344  0.351
1992 Mickisch G, Aksentijevich I, Schoenlein P, Goldstein L, Galski H, Stahle C, Sachs D, Pastan I, Gottesman M. Transplantation of bone marrow cells from transgenic mice expressing the human MDR1 gene results in long-term protection against the myelosuppressive effect of chemotherapy in mice Blood. 79: 1087-1093. DOI: 10.1182/blood.v79.4.1087.bloodjournal7941087  0.31
1991 Siegall CB, FitzGerald DJ, Pastan I. Selective killing of IL6 receptor bearing myeloma cells using recombinant IL6-Pseudomonas toxin. Current Topics in Microbiology and Immunology. 166: 63-9. PMID 2127396 DOI: 10.1007/978-3-642-75889-8_9  0.359
1991 FitzGerald D, Idziorek T, Batra JK, Willingham M, Pastan I. Antitumor activity of a thioether-linked immunotoxin: OVB3-PE. Bioconjugate Chemistry. 1: 264-8. PMID 2096919 DOI: 10.1021/BC00004A006  0.311
1991 Pai LH, Batra JK, FitzGerald DJ, Willingham MC, Pastan I. Anti-tumor activities of immunotoxins made of monoclonal antibody B3 and various forms of Pseudomonas exotoxin. Proceedings of the National Academy of Sciences of the United States of America. 88: 3358-62. PMID 2014255 DOI: 10.1073/PNAS.88.8.3358  0.341
1991 Batra JK, Fitzgerald DJ, Chaudhary VK, Pastan I. Single-chain immunotoxins directed at the human transferrin receptor containing Pseudomonas exotoxin A or diphtheria toxin: anti-TFR(Fv)-PE40 and DT388-anti-TFR(Fv). Molecular and Cellular Biology. 11: 2200-5. PMID 2005905 DOI: 10.1128/mcb.11.4.2200  0.36
1991 Chaudhary VK, FitzGerald DJ, Pastan I. A proper amino terminus of diphtheria toxin is important for cytotoxicity. Biochemical and Biophysical Research Communications. 180: 545-51. PMID 1953725 DOI: 10.1016/s0006-291x(05)81099-x  0.309
1991 Siegall CB, Ogata M, Pastan I, FitzGerald DJ. Analysis of sequences in domain II of Pseudomonas exotoxin A which mediate translocation. Biochemistry. 30: 7154-9. PMID 1906738 DOI: 10.1021/BI00243A016  0.318
1991 Prior TI, FitzGerald DJ, Pastan I. Barnase toxin: A new chimeric toxin composed of pseudomonas exotoxin A and barnase Cell. 64: 1017-1023. PMID 1900455 DOI: 10.1016/0092-8674(91)90325-S  0.358
1991 Epstein SE, Siegall CB, Biro S, Fu YM, FitzGerald D, Pastan I. Cytotoxic effects of a recombinant chimeric toxin on rapidly proliferating vascular smooth muscle cells. Circulation. 84: 778-87. PMID 1860221 DOI: 10.1161/01.CIR.84.2.778  0.363
1991 Siegall CB, Epstein S, Speir E, Hla T, Forough R, Maciag T, Fitzgerald DJ, Pastan I. Cytotoxic activity of chimeric proteins composed of acidic fibroblast growth factor and Pseudomonas exotoxin on a variety of cell types. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 5: 2843-9. PMID 1717336 DOI: 10.1096/Fasebj.5.13.1717336  0.303
1991 Ogata M, Pastan I, FitzGerald D. Analysis of Pseudomonas exotoxin activation and conformational changes by using monoclonal antibodies as probes. Infection and Immunity. 59: 407-14. PMID 1702764 DOI: 10.1128/IAI.59.1.407-414.1991  0.322
1991 Pastan I, FitzGerald D. Recombinant toxins for cancer treatment. Science (New York, N.Y.). 254: 1173-7. PMID 1683495 DOI: 10.1126/SCIENCE.1683495  0.364
1991 Mickisch GH, Merlino GT, Aiken PM, Gottesman MM, Pastan I. New potent verapamil derivatives that reverse multidrug resistance in human renal carcinoma cells and in transgenic mice expressing the human MDR1 gene. The Journal of Urology. 146: 447-53. PMID 1677434 DOI: 10.1016/S0022-5347(17)37822-9  0.312
1991 Padmanabhan R, Tsuruo T, Kane SE, Willingham MC, Howard BH, Gottesman MM, Pastan I. Magnetic-affinity cell sorting of human multidrug-resistant cells. Journal of the National Cancer Institute. 83: 565-9. PMID 1672384 DOI: 10.1093/Jnci/83.8.565  0.336
1991 Heimbrook DC, Stirdivant SM, Ahern JD, Balishin NL, Patrick DR, Edwards GM, Defeo-Jones D, FitzGerald DJ, Pastan I, Oliff A. Biological activity of a transforming growth factor-alpha--Pseudomonas exotoxin fusion protein in vitro and in vivo. Journal of Industrial Microbiology. 7: 203-7. PMID 1367127 DOI: 10.1007/BF01575884  0.319
1990 Kane SE, Reinhard DH, Fordis CM, Pastan I, Gottesman MM. A new vector using the human multidrug resistance gene as a selectable marker enables overexpression of foreign genes in eukaryotic cells. Gene. 84: 439-46. PMID 2575560 DOI: 10.1016/0378-1119(89)90518-0  0.36
1990 Kageyama R, Pastan I. Molecular cloning and characterization of a human DNA binding factor that represses transcription. Cell. 59: 815-25. PMID 2556218 DOI: 10.1016/0092-8674(89)90605-3  0.325
1990 Ueda K, Yamano Y, Kioka N, Kakehi Y, Yoshida O, Gottesman MM, Pastan I, Komano T. Detection of multidrug resistance (MDR1) gene RNA expression in human tumors by a sensitive ribonuclease protection assay. Japanese Journal of Cancer Research : Gann. 80: 1127-32. PMID 2481665 DOI: 10.1111/j.1349-7006.1989.tb02269.x  0.338
1990 Batra JK, Chaudhary VK, FitzGerald D, Pastan I. TGF alpha-anti-Tac(Fv)-PE40: a bifunctional toxin cytotoxic for cells with EGF or IL2 receptors. Biochemical and Biophysical Research Communications. 171: 1-6. PMID 2393383 DOI: 10.1016/0006-291x(90)91347-u  0.338
1990 Chaudhary VK, Gallo MG, FitzGerald DJ, Pastan I. A recombinant single-chain immunotoxin composed of anti-Tac variable regions and a truncated diphtheria toxin. Proceedings of the National Academy of Sciences of the United States of America. 87: 9491-4. PMID 2251289 DOI: 10.1073/pnas.87.23.9491  0.349
1990 Kreitman RJ, Chaudhary VK, Waldmann T, Willingham MC, FitzGerald DJ, Pastan I. The recombinant immunotoxin anti-Tac(Fv)-Pseudomonas exotoxin 40 is cytotoxic toward peripheral blood malignant cells from patients with adult T-cell leukemia. Proceedings of the National Academy of Sciences of the United States of America. 87: 8291-5. PMID 2236041 DOI: 10.1073/Pnas.87.21.8291  0.362
1990 Chaudhary VK, Batra JK, Gallo MG, Willingham MC, FitzGerald DJ, Pastan I. A rapid method of cloning functional variable-region antibody genes in Escherichia coli as single-chain immunotoxins. Proceedings of the National Academy of Sciences of the United States of America. 87: 1066-70. PMID 2105495 DOI: 10.1073/pnas.87.3.1066  0.331
1990 Chaudhary VK, Jinno Y, FitzGerald D, Pastan I. Pseudomonas exotoxin contains a specific sequence at the carboxyl terminus that is required for cytotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 87: 308-12. PMID 2104981 DOI: 10.1073/pnas.87.1.308  0.303
1990 Kane SE, Pastan I, Gottesman MM. Genetic basis of multidrug resistance of tumor cells. Journal of Bioenergetics and Biomembranes. 22: 593-618. PMID 1977744 DOI: 10.1007/Bf00762963  0.317
1990 Sugawara I, Koji T, Ueda K, Pastan I, Gottesman MM, Nakane PK, Mori S. In situ localization of the human multidrug-resistance gene mRNA using thymine-thymine dimerized single-stranded cDNA. Japanese Journal of Cancer Research : Gann. 81: 949-55. PMID 1977730 DOI: 10.1111/j.1349-7006.1990.tb02672.x  0.321
1990 Germann UA, Willingham MC, Pastan I, Gottesman MM. Expression of the human multidrug transporter in insect cells by a recombinant baculovirus. Biochemistry. 29: 2295-303. PMID 1970935 DOI: 10.1021/Bi00461A013  0.327
1990 Germann UA, Chin KV, Pastan I, Gottesman MM. Retroviral transfer of a chimeric multidrug resistance-adenosine deaminase gene. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 4: 1501-7. PMID 1968408 DOI: 10.1096/fasebj.4.5.1968408  0.352
1990 Tanaka S, Currier SJ, Bruggemann EP, Ueda K, Germann UA, Pastan I, Gottesman MM. Use of recombinant P-glycoprotein fragments to produce antibodies to the multidrug transporter. Biochemical and Biophysical Research Communications. 166: 180-6. PMID 1967936 DOI: 10.1016/0006-291X(90)91928-L  0.333
1989 Gottesman MM, Pastan I. Resistance to multiple chemotherapeutic agents in human cancer cells. Trends in Pharmacological Sciences. 9: 54-8. PMID 3072730 DOI: 10.1016/0165-6147(88)90117-4  0.34
1989 Richert ND, Aldwin L, Nitecki D, Gottesman MM, Pastan I. Stability and covalent modification of P-glycoprotein in multidrug-resistant KB cells. Biochemistry. 27: 7607-13. PMID 2905169 DOI: 10.1021/Bi00420A006  0.316
1989 Lai SL, Goldstein LJ, Gottesman MM, Pastan I, Tsai CM, Johnson BE, Mulshine JL, Ihde DC, Kayser K, Gazdar AF. MDR1 gene expression in lung cancer. Journal of the National Cancer Institute. 81: 1144-50. PMID 2746668 DOI: 10.1093/Jnci/81.15.1144  0.302
1989 Kanamaru H, Kakehi Y, Yoshida O, Nakanishi S, Pastan I, Gottesman MM. MDR1 RNA levels in human renal cell carcinomas: Correlation with grade and prediction of reversal of doxorubicin resistance by quinidine in tumor explants Journal of the National Cancer Institute. 81: 844-849. PMID 2724349 DOI: 10.1093/Jnci/81.11.844  0.303
1989 Kioka N, Tsubota J, Kakehi Y, Komano T, Gottesman MM, Pastan I, Ueda K. P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance. Biochemical and Biophysical Research Communications. 162: 224-31. PMID 2568832 DOI: 10.1016/0006-291X(89)91985-2  0.318
1989 Konen PL, Currier SJ, Rutherford AV, Gottesman MM, Pastan I, Willingham MC. The multidrug transporter: rapid modulation of efflux activity monitored in single cells by the morphologic effects of vinblastine and daunomycin. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 37: 1141-5. PMID 2567301 DOI: 10.1177/37.7.2567301  0.325
1989 Velu TJ, Beguinot L, Vass WC, Zhang K, Pastan I, Lowy DR. Retroviruses expressing different levels of the normal epidermal growth factor receptor: biological properties and new bioassay. Journal of Cellular Biochemistry. 39: 153-66. PMID 2565908 DOI: 10.1002/JCB.240390207  0.327
1989 Siegall CB, Xu YH, Chaudhary VK, Adhya S, Fitzgerald D, Pastan I. Cytotoxic activities of a fusion protein comprised of TGF alpha and Pseudomonas exotoxin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 3: 2647-52. PMID 2556314 DOI: 10.1096/Fasebj.3.14.2556314  0.328
1989 FitzGerald D, Pastan I. Targeted toxin therapy for the treatment of cancer. Journal of the National Cancer Institute. 81: 1455-63. PMID 2550658 DOI: 10.1093/JNCI/81.19.1455  0.384
1989 Batra JK, Jinno Y, Chaudhary VK, Kondo T, Willingham MC, FitzGerald DJ, Pastan I. Antitumor activity in mice of an immunotoxin made with anti-transferrin receptor and a recombinant form of Pseudomonas exotoxin. Proceedings of the National Academy of Sciences of the United States of America. 86: 8545-9. PMID 2510169 DOI: 10.1073/pnas.86.21.8545  0.358
1989 Chaudhary VK, Queen C, Junghans RP, Waldmann TA, FitzGerald DJ, Pastan I. A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin. Nature. 339: 394-7. PMID 2498664 DOI: 10.1038/339394A0  0.345
1989 Banker DE, Pastan I, Gottesman MM, Herschman HR. An epidermal growth factor-ricin A chain (EGF-RTA)-resistant mutant and an epidermal growth factor-Pseudomonas endotoxin (EGF-PE)-resistant mutant have distinct phenotypes. Journal of Cellular Physiology. 139: 51-7. PMID 2496133 DOI: 10.1002/Jcp.1041390109  0.337
1988 Velu TJ, Beguinot L, Vass WC, Willingham MC, Merlino GT, Pastan I, Lowy DR. Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogene. Science (New York, N.Y.). 238: 1408-10. PMID 3500513 DOI: 10.1126/SCIENCE.3500513  0.328
1988 Kageyama R, Merlino GT, Pastan I. A transcription factor active on the epidermal growth factor receptor gene. Proceedings of the National Academy of Sciences of the United States of America. 85: 5016-20. PMID 3393529 DOI: 10.1073/PNAS.85.14.5016  0.302
1988 Amano F, Pastan I, Gottesman MM. Genetic characterization of human KB cell lines resistant to epidermal growth factor: Pseudomonas exotoxin conjugates. Journal of Cellular Physiology. 135: 527-32. PMID 3260900 DOI: 10.1002/jcp.1041350323  0.332
1988 Pastan I, Gottesman MM, Ueda K, Lovelace E, Rutherford AV, Willingham MC. A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells. Proceedings of the National Academy of Sciences of the United States of America. 85: 4486-90. PMID 2898143 DOI: 10.1073/Pnas.85.12.4486  0.324
1988 Kane SE, Troen BR, Gal S, Ueda K, Pastan I, Gottesman MM. Use of cloned multidrug resistance gene for coamplification and overproduction of major excreted protein,a transformation-regulated secreted acid protease Molecular and Cellular Biology. 8: 3316-3321. PMID 2463474 DOI: 10.1128/Mcb.8.8.3316  0.358
1987 Fojo AT, Shen DW, Mickley LA, Pastan I, Gottesman MM. Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug-resistance gene. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 5: 1922-7. PMID 3681376 DOI: 10.1200/Jco.1987.5.12.1922  0.307
1987 Hasumura S, Kitagawa S, Lovelace E, Willingham MC, Pastan I, Cheng S. Characterization of a membrane-associated 3,3',5-triiodo-L-thyronine binding protein by use of monoclonal antibodies. Biochemistry. 25: 7881-8. PMID 3542039 DOI: 10.1021/bi00372a014  0.341
1987 FitzGerald DJ, Willingham MC, Cardarelli CO, Hamada H, Tsuruo T, Gottesman MM, Pastan I. A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells. Proceedings of the National Academy of Sciences of the United States of America. 84: 4288-92. PMID 3495806 DOI: 10.1073/Pnas.84.12.4288  0.333
1987 Ueda K, Cardarelli C, Gottesman MM, Pastan I. Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine. Proceedings of the National Academy of Sciences of the United States of America. 84: 3004-8. PMID 3472246 DOI: 10.1073/Pnas.84.9.3004  0.328
1987 Chaudhary VK, FitzGerald DJ, Adhya S, Pastan I. Activity of a recombinant fusion protein between transforming growth factor type alpha and Pseudomonas toxin. Proceedings of the National Academy of Sciences of the United States of America. 84: 4538-42. PMID 3299371 DOI: 10.1073/Pnas.84.13.4538  0.335
1987 Cornwell MM, Tsuruo T, Gottesman MM, Pastan I. ATP-binding properties of P glycoprotein from multidrug-resistant KB cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 1: 51-4. PMID 2886389 DOI: 10.1096/Fasebj.1.1.2886389  0.321
1987 Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I, Willingham MC. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proceedings of the National Academy of Sciences of the United States of America. 84: 7735-8. PMID 2444983 DOI: 10.1073/pnas.84.21.7735  0.327
1987 Hwang J, Richert N, Pastan I, Gottesman MM. Mutant KB cells with decreased EGF receptor expression: biochemical characterization. Journal of Cellular Physiology. 133: 127-34. PMID 2444605 DOI: 10.1002/jcp.1041330116  0.325
1986 Shen DW, Fojo A, Roninson IB, Chin JE, Soffir R, Pastan I, Gottesman MM. Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene. Molecular and Cellular Biology. 6: 4039-45. PMID 3796599 DOI: 10.1128/Mcb.6.11.4039  0.327
1986 Roninson IB, Chin JE, Choi KG, Gros P, Housman DE, Fojo A, Shen DW, Gottesman MM, Pastan I. Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells. Proceedings of the National Academy of Sciences of the United States of America. 83: 4538-42. PMID 3459187 DOI: 10.1073/Pnas.83.12.4538  0.319
1986 Cornwell MM, Safa AR, Felsted RL, Gottesman MM, Pastan I. Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling. Proceedings of the National Academy of Sciences of the United States of America. 83: 3847-50. PMID 3459160 DOI: 10.1073/Pnas.83.11.3847  0.344
1986 Cheng SY, Hasumura S, Willingham MC, Pastan I. Purification and characterization of a membrane-associated 3,3',5-triiodo-L-thyronine binding protein from a human carcinoma cell line. Proceedings of the National Academy of Sciences of the United States of America. 83: 947-51. PMID 3006034 DOI: 10.1073/pnas.83.4.947  0.322
1986 King CR, Kraus MH, Williams LT, Merlino GT, Pastan IH, Aaronson SA. Human tumor cell lines with EGF receptor gene amplification in the absence of aberrant sized mRNAs. Nucleic Acids Research. 13: 8477-86. PMID 3001641 DOI: 10.1093/Nar/13.23.8477  0.561
1986 Pastan I, Hanover J, Willingham M. The cellular entry of EGF and transferrin: a problem in intracellular sorting. Current Topics in Cellular Regulation. 26: 17-25. PMID 3000694 DOI: 10.1016/B978-0-12-152826-3.50009-7  0.488
1986 Ueda K, Cornwell MM, Gottesman MM, Pastan I, Roninson IB, Ling V, Riordan JR. The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein. Biochemical and Biophysical Research Communications. 141: 956-62. PMID 2880583 DOI: 10.1016/S0006-291X(86)80136-X  0.31
1986 Chen Cj, Chin JE, Ueda K, Clark DP, Pastan I, Gottesman MM, Roninson IB. Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells Cell. 47: 381-389. PMID 2876781 DOI: 10.1016/0092-8674(86)90595-7  0.32
1986 Hanover JA, D'Souza P, August T, Pastan I, Willingham MC. Monoclonal antibodies against a glycoprotein localized in coated pits and endocytic vesicles inhibit α2-macroglobulin binding and uptake Journal of Biological Chemistry. 261: 16732-16737. PMID 2430970  0.527
1985 Willingham MC, Pastan I. Endocytosis and exocytosis: current concepts of vesicle traffic in animal cells. International Review of Cytology. 92: 51-92. PMID 6150907 DOI: 10.1016/S0074-7696(08)61324-8  0.306
1985 Gottesman MM, Roth C, Vlahakis G, Pastan I. Cholera toxin treatment stimulates tumorigenicity of Rous sarcoma virus-transformed cells. Molecular and Cellular Biology. 4: 2639-42. PMID 6098816 DOI: 10.1128/Mcb.4.12.2639  0.321
1985 Xu YH, Richert N, Ito S, Merlino GT, Pastan I. Characterization of epidermal growth factor receptor gene expression in malignant and normal human cell lines. Proceedings of the National Academy of Sciences of the United States of America. 81: 7308-12. PMID 6095284 DOI: 10.1073/PNAS.81.23.7308  0.342
1985 Hanover JA, Pastan I, Willingham MC. Inhibition of phosphatidylcholine synthesis does not alter uptake of transferrin by LM fibroblasts Experimental Cell Research. 157: 276-281. PMID 3972013 DOI: 10.1016/0014-4827(85)90170-3  0.544
1985 Pirker R, FitzGerald DJP, Hamilton TC, Ozols RF, Laird W, Frankel AE, Willingham MC, Pastan I. Characterization of immunotoxins active against ovarian cancer cell lines Journal of Clinical Investigation. 76: 1261-1267. PMID 3930572 DOI: 10.1172/Jci112082  0.349
1985 Perrotti N, Taylor SI, Richert ND, Rapp UR, Pastan IH, Roth J. Immunoprecipitation of insulin receptors from cultured human lymphocytes (IM-9 cells) by antibodies to pp60src. Science (New York, N.Y.). 227: 761-3. PMID 3918346 DOI: 10.1126/Science.3918346  0.3
1985 Fojo AT, Whang-Peng J, Gottesman MM, Pastan I. Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells. Proceedings of the National Academy of Sciences of the United States of America. 82: 7661-5. PMID 3865187 DOI: 10.1073/Pnas.82.22.7661  0.303
1985 Richert N, Akiyama S, Shen D, Gottesman MM, Pastan I. Multiply drug-resistant human KB carcinoma cells have decreased amounts of a 75-kDa and a 72-kDa glycoprotein. Proceedings of the National Academy of Sciences of the United States of America. 82: 2330-3. PMID 3857583 DOI: 10.1073/Pnas.82.8.2330  0.324
1985 Akiyama Si, Fojo A, Hanover JA, Pastan I, Gottesman MM. Isolation and genetic characterization of human KB cell lines resistant to multiple drugs Somatic Cell and Molecular Genetics. 11: 117-126. PMID 3856953 DOI: 10.1007/BF01534700  0.514
1985 Hunts JH, Shimizu N, Yamamoto T, Toyoshima K, Merlino GT, Xu YH, Pastan I. Translocation chromosome 7 of A431 cells contains amplification and rearrangement of EGF receptor gene responsible for production of variant mRNA. Somatic Cell and Molecular Genetics. 11: 477-84. PMID 2994239 DOI: 10.1007/Bf01534841  0.316
1985 Ishii S, Xu YH, Stratton RH, Roe BA, Merlino GT, Pastan I. Characterization and sequence of the promoter region of the human epidermal growth factor receptor gene. Proceedings of the National Academy of Sciences of the United States of America. 82: 4920-4. PMID 2991899 DOI: 10.1073/pnas.82.15.4920  0.307
1985 Merlino GT, Xu Y, Richert N, Clark AJL, Ishii S, Banks-Schlegel S, Pastan I. Elevated epidermal growth factor receptor gene copy number and expression in a squamous carcinoma cell line. Journal of Clinical Investigation. 75: 1077-1079. PMID 2984254 DOI: 10.1172/Jci111770  0.333
1985 Lyall RM, Pastan I, Willingham MC. EGF induces receptor down-regulation with no receptor recycling in KB cells. Journal of Cellular Physiology. 122: 166-70. PMID 2981235 DOI: 10.1002/JCP.1041220125  0.305
1985 Hanover JA, Beguinot L, Willingham MC, Pastan IH. Transit of receptors for epidermal growth factor and transferrin through clathrin-coated pits. Analysis of the kinetics of receptor entry Journal of Biological Chemistry. 260: 15938-15945. PMID 2866188  0.483
1985 Beguinot L, Hanover JA, Ito S, Richert ND, Willingham MC, Pastan I. Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors Proceedings of the National Academy of Sciences of the United States of America. 82: 2774-2778. PMID 2859591 DOI: 10.1073/Pnas.82.9.2774  0.554
1985 Dickson RB, Hanover JA, Pastan I, Willingham MC. Isolation of receptosomes (endosomes) from human KB cells Methods in Enzymology. 257-271. PMID 2859514 DOI: 10.1016/0076-6879(85)09091-7  0.569
1985 Chen JW, Murphy TL, Willingham MC, Pastan I, August JT. Identification of two lysosomal membrane glycoproteins. The Journal of Cell Biology. 101: 85-95. PMID 2409098 DOI: 10.1083/JCB.101.1.85  0.325
1984 Seth P, Fitzgerald D, Ginsberg H, Willingham M, Pastan I. Evidence that the penton base of adenovirus is involved in potentiation of toxicity of Pseudomonas exotoxin conjugated to epidermal growth factor. Molecular and Cellular Biology. 4: 1528-33. PMID 6333584 DOI: 10.1128/MCB.4.8.1528  0.315
1984 Seth P, Fitzgerald DJ, Willingham MC, Pastan I. Role of a low-pH environment in adenovirus enhancement of the toxicity of a Pseudomonas exotoxin-epidermal growth factor conjugate. Journal of Virology. 51: 650-5. PMID 6332200 DOI: 10.1128/JVI.51.3.650-655.1984  0.317
1984 Xu YH, Ishii S, Clark AJ, Sullivan M, Wilson RK, Ma DP, Roe BA, Merlino GT, Pastan I. Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells. Nature. 309: 806-10. PMID 6330563 DOI: 10.1038/309806a0  0.326
1984 McKeon C, Pastan I, de Crombrugghe B. DNase I sensitivity of the alpha 2(I) collagen gene: correlation with its expression but not with its methylation pattern. Nucleic Acids Research. 12: 3491-502. PMID 6328424 DOI: 10.1093/nar/12.8.3491  0.549
1984 Beguinot L, Lyall RM, Willingham MC, Pastan I. Down-regulation of the epidermal growth factor receptor in KB cells is due to receptor internalization and subsequent degradation in lysosomes. Proceedings of the National Academy of Sciences of the United States of America. 81: 2384-8. PMID 6326124 DOI: 10.1073/PNAS.81.8.2384  0.312
1984 Willingham MC, Pastan I. Endocytosis and membrane traffic in cultured cells. Recent Progress in Hormone Research. 40: 569-87. PMID 6207568 DOI: 10.1016/B978-0-12-571140-1.50018-9  0.326
1984 Merlino GT, Xu YH, Ishii S, Clark AJ, Semba K, Toyoshima K, Yamamoto T, Pastan I. Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells. Science (New York, N.Y.). 224: 417-9. PMID 6200934 DOI: 10.1126/Science.6200934  0.31
1984 Hanover JA, Willingham MC, Pastan I. Kinetics of transit of transferrin and epidermal growth factor through clathrin-coated membranes Cell. 39: 283-293. PMID 6149810 DOI: 10.1016/0092-8674(84)90006-0  0.539
1984 Willingham MC, Strader CD, Lefkowitz RJ, Pastan I. Morphologic demonstration of clathrin-coated pits in frog and turkey erythrocytes. Experimental Cell Research. 151: 573-7. PMID 6142826 DOI: 10.1016/0014-4827(84)90406-3  0.454
1984 Willingham MC, Hanover JA, Dickson RB, Pastan I. Morphologic characterization of the pathway of transferrin endocytosis and recycling in human KB cells Proceedings of the National Academy of Sciences of the United States of America. 81: 175-179. PMID 6141558 DOI: 10.1073/pnas.81.1.175  0.574
1984 Hasumura S, Rossi B, Alderson R, Pastan I, Cheng S. Antibodies against the plasma membrane 3,3',5-triiodo-L-thyronine binding protein of rat pituitary GH3 cells: partial characterization and cross-species immunoreactivity. Biochemical and Biophysical Research Communications. 124: 956-62. PMID 6095830 DOI: 10.1016/0006-291X(84)91051-9  0.32
1984 Akiyama T, Yamada Y, Ogawara H, Richert N, Pastan I, Yamamoto T, Kasuga M. Site-specific antibodies to the erbB oncogene product immunoprecipitate epidermal growth factor receptor. Biochemical and Biophysical Research Communications. 123: 797-802. PMID 6091642 DOI: 10.1016/0006-291X(84)90300-0  0.318
1984 Akiyama S, Gottesman MM, Hanover JA, Fitzgerald DJ, Willingham MC, Pastan I. Verapamil enhances the toxicity of conjugates of epidermal growth factor with Pseudomonas exotoxin and antitransferrin receptor with Pseudomonas exotoxin Journal of Cellular Physiology. 120: 271-279. PMID 6086678 DOI: 10.1002/jcp.1041200303  0.574
1983 Hanover JA, Rudick JE, Willingham MC, Pastan I. α2-macroglobulin binding to cultured fibroblasts: Identification by affinity chromatography of high-affinity binding sites Archives of Biochemistry and Biophysics. 227: 570-579. PMID 6667030 DOI: 10.1016/0003-9861(83)90486-1  0.543
1983 Mato JM, Pencev D, Vasanthakumar G, Schiffmann E, Pastan I. Inhibitors of endocytosis perturb phospholipid metabolism in rabbit neutrophils and other cells. Proceedings of the National Academy of Sciences of the United States of America. 80: 1929-32. PMID 6572951 DOI: 10.1073/PNAS.80.7.1929  0.307
1983 Hirano H, Yamada Y, Sullivan M, de Crombrugghe B, Pastan I, Yamada KM. Isolation of genomic DNA clones spanning the entire fibronectin gene. Proceedings of the National Academy of Sciences of the United States of America. 80: 46-50. PMID 6572007 DOI: 10.1073/pnas.80.1.46  0.63
1983 Dickson RB, Hanover JA, Willingham MC, Pastan I. Prelysosomal divergence of transferrin and epidermal growth factor during receptor-mediated endocytosis Biochemistry. 22: 5667-5674. PMID 6317024 DOI: 10.1021/Bi00293A033  0.543
1983 Dickson RB, Beguinot L, Hanover JA, Richert ND, Willingham MC, Pastan I. Isolation and characterization of a highly enriched preparation of receptosomes (endosomes) from a human cell line Proceedings of the National Academy of Sciences of the United States of America. 80: 5335-5339. PMID 6310570 DOI: 10.1073/Pnas.80.17.5335  0.567
1983 FitzGerald DJ, Trowbridge IS, Pastan I, Willingham MC. Enhancement of toxicity of antitransferrin receptor antibody-Pseudomonas exotoxin conjugates by adenovirus. Proceedings of the National Academy of Sciences of the United States of America. 80: 4134-8. PMID 6306663 DOI: 10.1073/Pnas.80.13.4134  0.327
1983 Hanover JA, Willingham MC, Pastan I. Receptor-mediated endocytosis of α2-macroglobulin: Solubilization and partial purification of the fibroblast α2-macroglobulin receptor Annals of the New York Academy of Sciences. 410-423. PMID 6202215 DOI: 10.1111/J.1749-6632.1983.Tb18135.X  0.558
1983 Merlino GT, McKeon C, de Crombrugghe B, Pastan I. Regulation of the expression of genes encoding types I, II, and III collagen during chick embryonic development. The Journal of Biological Chemistry. 258: 10041-8. PMID 6193105  0.501
1983 Hanover JA, Cheng S, Willingham MC, Pastan IH. α2-Macroglobulin binding to cultured fibroblasts. Solubilization and partial purification of binding sites Journal of Biological Chemistry. 258: 370-377. PMID 6184373  0.5
1983 FitzGerald DJ, Padmanabhan R, Pastan I, Willingham MC. Adenovirus-induced release of epidermal growth factor and pseudomonas toxin into the cytosol of KB cells during receptor-mediated endocytosis. Cell. 32: 607-17. PMID 6130853 DOI: 10.1016/0092-8674(83)90480-4  0.309
1983 Pastan I, Willingham MC. Receptor-mediated endocytosis: coated pits, receptosomes and the Golgi Trends in Biochemical Sciences. 8: 250-254. DOI: 10.1016/0968-0004(83)90351-1  0.313
1982 Tyagi JS, Merlino GT, de Crombrugghe B, Pastan I. Chicken embryo extracts contain a factor that preferentially blocks the accumulation of RNA polymerase II transcripts in a cell-free system. The Journal of Biological Chemistry. 257: 13001-8. PMID 7130191  0.511
1982 Vogeli G, Ohkubo H, Sobel ME, Yamada Y, Pastan I, de Crombrugghe B. Structure of the promoter for chicken α2 type I collagen gene Proceedings of the National Academy of Sciences of the United States of America. 78: 5334-5338. PMID 6946474 DOI: 10.1073/pnas.78.9.5334  0.546
1982 Gorman CM, Merlino GT, Willingham MC, Pastan I, Howard BH. The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection Proceedings of the National Academy of Sciences of the United States of America. 79: 6777-6781. PMID 6294651 DOI: 10.1073/pnas.79.22.6777  0.362
1982 Horiuchi R, Johnson ML, Willingham MC, Pastan I, Cheng S. Affinity labeling of the plasma membrane 3,3',5-triiodo-L-thyronine receptor in GH3 cells. Proceedings of the National Academy of Sciences of the United States of America. 79: 5527-31. PMID 6291049 DOI: 10.1073/pnas.79.18.5527  0.341
1982 Pastan IH, Willingham M, de Crombrugghe B, Gottesman MM. Aging and cancer: cyclic 3', 5'-adenosine monophosphate and altered gene activity. National Cancer Institute Monograph. 60: 7-15. PMID 6289108  0.453
1982 Roth CW, Singh T, Pastan I, Gottesman MM. Rous sarcoma virus transformed cells are resistant to cyclic AMP. Journal of Cellular Physiology. 111: 42-8. PMID 6282904 DOI: 10.1002/jcp.1041110108  0.324
1982 Merlino GT, Tyagi JS, de Crombrugghe B, Pastan I. Transcription of the chicken alpha 2 (Type I) collagen gene by homologous cell-free extracts. The Journal of Biological Chemistry. 257: 7254-61. PMID 6282836  0.531
1981 Pretorius HT, Nandi PK, Lippoldt RE, Johnson ML, Keen JH, Pastan I, Edelhoch H. Molecular characterization of human clathrin. Biochemistry. 20: 2777-82. PMID 7248247 DOI: 10.1021/Bi00513A011  0.546
1981 Willingham MC, Yamada SS, Davies PJ, Rutherford AV, Gallo MG, Pastan I. Intracellular localization of actin in cultured fibroblasts by electron microscopic immunocytochemistry. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 29: 17-37. PMID 7009728 DOI: 10.1177/29.1.7009728  0.31
1981 Vogeli G, Ohkubo H, Avvedimento VE, Sullivan M, Yamada Y, Mudryj M, Pastan I, de Crombrugghe B. A repetitive structure in the chick alpha 2-collagen gene. Cold Spring Harbor Symposia On Quantitative Biology. 45: 777-83. PMID 6942950 DOI: 10.1101/Sqb.1981.045.01.096  0.524
1981 Merlino GT, Vogeli G, Yamamoto T, de Crombrugghe B, Pastan I. Accurate in vitro transcriptional initiation of the chick alpha 2 (Type I) collagen gene. The Journal of Biological Chemistry. 256: 11251-8. PMID 6270147  0.515
1981 Dickson LA, Ninomiya Y, Bernard MP, Pesciotta DM, Parsons J, Green G, Eikenberry EF, de Crombrugghe B, Vogeli G, Pastan I, Fietzek PP, Olsen BR. The exon/intron structure of the 3'-region of the pro alpha 2(I) collagen gene. The Journal of Biological Chemistry. 256: 8407-15. PMID 6267043  0.478
1981 LeCam A, Gottesman MM, Pastan I. Glycogen synthase activity in Chinese hamster ovary cells. Studies with wild-type and mutant cells defective in cyclic AMP-dependent protein kinase. Biochimica Et Biophysica Acta. 675: 94-100. PMID 6266497 DOI: 10.1016/0304-4165(81)90073-8  0.308
1981 Sobel ME, Yamamoto T, De Crombrugghe B, Pastan I. Regulation of procollagen messenger ribonucleic acid levels in Rous sarcoma virus transformed chick embryo fibroblasts Biochemistry. 20: 2678-2684. PMID 6263317 DOI: 10.1021/Bi00512A049  0.549
1981 Fagan JB, Sobel ME, Yamada KM, de Crombrugghe B, Pastan I. Effects of transformation on fibronectin gene expression using cloned fibronectin cDNA Journal of Biological Chemistry. 256: 520-525. PMID 6256355  0.469
1981 Maxfield FR, Willingham MC, Pastan I, Dragsten P, Cheng SY. Binding and mobility of the cell surface receptors for 3,3',5-triiodo-L-thyronine. Science (New York, N.Y.). 211: 63-5. PMID 6255563  0.475
1981 Maxfield FR, Willingham MC, Haigler HT, Dragsten P, Pastan IH. Binding, surface mobility, internalization, and degradation of rhodamine-labeled alpha 2-macroglobulin. Biochemistry. 20: 5353-8. PMID 6170323 DOI: 10.1021/Bi00521A041  0.484
1980 Yamada Y, Avvedimento VE, Mudryj M, Ohkubo H, Vogeli G, Irani M, Pastan I, de Crombrugghe B. The collagen gene: evidence for its evolutinary assembly by amplification of a DNA segment containing an exon of 54 bp. Cell. 22: 887-92. PMID 7460017 DOI: 10.1016/0092-8674(80)90565-6  0.54
1980 Vogeli G, Avvedimento EV, Sullivan M, Maizel JV, Lozano G, Adams SL, Pastan I, de Crombrugghe B. Isolation and characterization of genomic DNA coding for α2 type I collagen Nucleic Acids Research. 8: 1823-1837. PMID 7433131 DOI: 10.1093/Nar/8.8.1823  0.54
1980 Haigler HT, Willingham MC, Pastan I. Inhibitors of 125I-epidermal growth factor internalization Biochemical and Biophysical Research Communications. 94: 630-637. PMID 6967318 DOI: 10.1016/0006-291X(80)91279-6  0.324
1980 Ohkubo H, Vogeli G, Mudryj M, Avvedimento VE, Sullivan M, Pastan I, de Crombrugghe B. Isolation and characterization of overlapping genomic clones covering the chicken alpha 2 (type I) collagen gene. Proceedings of the National Academy of Sciences of the United States of America. 77: 7059-63. PMID 6452631 DOI: 10.1073/Pnas.77.12.7059  0.551
1980 Yamamoto T, de Crombrugghe B, Pastan I. Identification of a functional promoter in the long terminal repeat of Rous sarcoma virus. Cell. 22: 787-97. PMID 6257399 DOI: 10.1016/0092-8674(80)90555-3  0.551
1980 Davies PJA, Chabay R, Zech L, Berman M, Pastan I. Prostaglandin E1 binding and adenylate cyclase activation in normal and transformed fibroblasts Bba - General Subjects. 629: 282-291. PMID 6248120 DOI: 10.1016/0304-4165(80)90101-4  0.307
1980 Willingham MC, Pastan I, Shih TY, Scolnick EM. Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistry Cell. 19: 1005-1014. PMID 6247068 DOI: 10.1016/0092-8674(80)90091-4  0.306
1980 Gottesman MM, LeCam A, Bukowski M, Pastan I. Isolation of multiple classes of mutants of CHO cells resistant to cyclic AMP. Somatic Cell Genetics. 6: 45-61. PMID 6245473 DOI: 10.1007/BF01538695  0.305
1980 Yamamoto T, Sobel ME, Adams SL, Avvedimento VE, DiLauro R, Pastan I, de Crombrugghe B, Showalter A, Pesciotta D, Fietzek P, Olsen B. Construction of a recombinant bacterial plasmid containing pro-α1(I) collagen DNA sequences Journal of Biological Chemistry. 255: 2612-2615. PMID 6244285  0.469
1980 Haigler HT, Maxfield FR, Willingham MC, Pastan I. Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells. The Journal of Biological Chemistry. 255: 1239-41. PMID 6243633  0.508
1980 Willingham MC, Maxfield FR, Pastan I. Receptor-mediated endocytosis of alpha 2-macroglobulin in cultured fibroblasts. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 28: 818-23. PMID 6160180 DOI: 10.1177/28.8.6160180  0.552
1980 Avvedimento VE, Vogeli G, Yamada Y, Maizel JV, Pastan I, de Crombrugghe B. Correlation between splicing sites within an intron and their sequence complementarity with U1 RNA. Cell. 21: 689-96. PMID 6159982 DOI: 10.1016/0092-8674(80)90432-8  0.537
1980 Cheng SY, Maxfield FR, Robbins J, Willingham MC, Pastan IH. Receptor-mediated uptake of 3,3',5-triiodo-L-thyronine by cultured fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 77: 3425-9. PMID 6158047 DOI: 10.1073/Pnas.77.6.3425  0.487
1980 Willingham MC, Pastan I. The receptosome: an intermediate organelle of receptor mediated endocytosis in cultured fibroblasts. Cell. 21: 67-77. PMID 6157480 DOI: 10.1016/0092-8674(80)90115-4  0.308
1980 Davies PJ, Davies DR, Levitzki A, Maxfield FR, Milhaud P, Willingham MC, Pastan IH. Transglutaminase is essential in receptor-mediated endocytosis of alpha 2-macroglobulin and polypeptide hormones. Nature. 283: 162-7. PMID 6153122 DOI: 10.1038/283162A0  0.476
1980 Milhaud PG, Davies PJ, Pastan I, Gottesman MM. Regulation of transglutaminase activity in Chinese hamster ovary cells. Biochimica Et Biophysica Acta. 630: 476-84. PMID 6104988 DOI: 10.1016/0304-4165(80)90002-1  0.312
1980 Willingham MC, Jay G, Pastan I. Localization of the ASV src gene product to the plasma membrane of transformed cells by electron microscopic immunocytochemistry. Cell. 18: 125-34. PMID 228858 DOI: 10.1016/0092-8674(79)90361-1  0.324
1979 Fagan JB, Yamada KM, de Crombrugghe B, Pastan I. Partial purification and characterization of the messenger RNA for cell fibronectin. Nucleic Acids Research. 6: 3471-80. PMID 573888 DOI: 10.1093/nar/6.11.3471  0.615
1979 Pastan I. Cell transformation. Methods in Enzymology. 58: 368-70. PMID 423777 DOI: 10.1016/S0076-6879(79)58151-8  0.322
1979 Yamada KM, Olden K, Pastan I. Transformation-sensitive cell surface protein: isolation, characterization, and role in cellular morphology and adhesion. Annals of the New York Academy of Sciences. 312: 256-77. PMID 291364 DOI: 10.1111/j.1749-6632.1978.tb16807.x  0.523
1979 LeCam A, Maxfield F, Willingham M, Pastan I. Insulin stimulation of amino acid transport in isolated rat hepatocytes is independent of hormone internalization. Biochemical and Biophysical Research Communications. 88: 873-81. PMID 223575 DOI: 10.1016/0006-291X(79)91490-6  0.513
1979 Willingham MC, Maxfield FR, Pastan IH. alpha 2 Macroglobulin binding to the plasma membrane of cultured fibroblasts. Diffuse binding followed by clustering in coated regions. The Journal of Cell Biology. 82: 614-25. PMID 92473 DOI: 10.1083/Jcb.82.3.614  0.479
1979 Maxfield FR, Willingham MC, Davies PJ, Pastan I. Amines inhibit the clustering of alpha2-macroglobulin and EGF on the fibroblast cell surface. Nature. 277: 661-3. PMID 85262 DOI: 10.1038/277661A0  0.536
1979 Maxfield FR, Davies PJ, Klempner L, Willingham MC, Pastan I. Epidermal growth factor stimulation of DNA synthesis is potentiated by compounds that inhibit its clustering in coated pits. Proceedings of the National Academy of Sciences of the United States of America. 76: 5731-5. PMID 42903 DOI: 10.1073/Pnas.76.11.5731  0.546
1978 Anderson WB, Jaworski CJ, Gallo M, Pastan I, Pouysségur J. Adenylate cyclase in a fibroblast mutant defective in glycolipid and glycoprotein synthesis. Nature. 275: 223-4. PMID 692696 DOI: 10.1038/275223A0  0.339
1978 Yamada KM, Schlesinger DH, Kennedy DW, Pastan I. Characterization of a major fibroblast cell surface glycoprotein. Biochemistry. 16: 5552-9. PMID 562674 DOI: 10.1021/bi00644a025  0.48
1978 Sobel ME, Yamamoto T, Adams SL, DiLauro R, Avvedimento VE, de Crombrugghe B, Pastan I. Construction of a recombinant bacterial plasmid containing a chick pro-α2 collagen gene sequence Proceedings of the National Academy of Sciences of the United States of America. 75: 5846-5850. PMID 366605 DOI: 10.1073/Pnas.75.12.5846  0.553
1978 Pratt RM, Pastan I. Decreased binding of epidermal growth factor to BALB/c 3T3 mutant cells defective in glycoprotein synthesis. Nature. 272: 68-70. PMID 305006 DOI: 10.1038/272068A0  0.372
1978 Pastan I, Willingham M. Cellular transformation and the 'morphologic phenotype' of transformed cells. Nature. 274: 645-50. PMID 209337 DOI: 10.1038/274645A0  0.333
1978 Maxfield FR, Schlessinger J, Shechter Y, Pastan I, Willingham MC. Collection of insulin, EGF and alpha2-macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization. Cell. 14: 805-10. PMID 80283 DOI: 10.1016/0092-8674(78)90336-7  0.542
1978 Howard BH, Adams SL, Sobel ME, Pastan I, de Crombrugghe B. Decreased levels of collagen mRNA in Rous sarcoma virus-transformed chick embryo fibroblasts Journal of Biological Chemistry. 253: 5869-5874. PMID 78927  0.504
1977 Willingham MC, Yamada KM, Yamada SS, Pouysségur J, Pastan I. Microfilament bundles and cell shape are related to adhesiveness to substratum and are dissociable from growth control in cultured fibroblasts. Cell. 10: 375-80. PMID 557370 DOI: 10.1016/0092-8674(77)90024-1  0.492
1977 Schlessinger J, Barak LS, Hammes GG, Yamada KM, Pastan I, Webb WW, Elson EL. Mobility and distribution of a cell surface glycoprotein and its interaction with other membrane components. Proceedings of the National Academy of Sciences of the United States of America. 74: 2909-13. PMID 331320 DOI: 10.1073/Pnas.74.7.2909  0.494
1977 Yamada KM, Yamada SS, Pastan I. Quantitation of a transformation-sensitive, adhesive cell surface glycoprotein. Decrease of several untransformed permanent cell lines. The Journal of Cell Biology. 74: 649-54. PMID 328519 DOI: 10.1083/jcb.74.2.649  0.505
1977 Pouysségur J, Willingham M, Pastan I. Role of cell surface carbohydrates and proteins in cell behavior: studies on the biochemical reversion of an N-acetylglucosamine-deficient fibroblast mutant. Proceedings of the National Academy of Sciences of the United States of America. 74: 243-7. PMID 264677 DOI: 10.1073/PNAS.74.1.243  0.336
1977 Adams SL, Sobel ME, Howard BH, Olden K, Yamada KM, de Crombrugghe B, Pastan I. Levels of translatable mRNAs for cell surface protein, collagen precursors, and two membrane proteins are altered in Rous sarcoma virus transformed chick embryo fibroblasts Proceedings of the National Academy of Sciences of the United States of America. 74: 3399-3403. PMID 198783 DOI: 10.1073/pnas.74.8.3399  0.646
1977 Yamada KM, Pastan I. The relationship between cell surface protein and glucose and alpha-aminoisobutyrate transport in transformed chick and mouse cells. Journal of Cellular Physiology. 89: 827-9. PMID 188852 DOI: 10.1002/jcp.1040890450  0.483
1977 Ostlund RE, Pastan I. The purification and quantitation of myosin from cultured cells. Biochimica Et Biophysica Acta. 453: 37-47. PMID 136988 DOI: 10.1016/0005-2795(76)90248-8  0.337
1976 Yamada KM, Yamada SS, Pastan I. The major cell surface glycoprotein of chick embryo fibroblasts is an agglutinin. Proceedings of the National Academy of Sciences of the United States of America. 72: 3158-62. PMID 1059102 DOI: 10.1073/pnas.72.8.3158  0.511
1976 Thomopoulos P, Roth J, Lovelace E, Pastan I. Insulin receptors in normal and transformed fibroblasts: relationship to growth and transformation Cell. 8: 417-423. PMID 954096 DOI: 10.1016/0092-8674(76)90154-9  0.388
1976 Olden K, Willingham M, Pastan I. Cell surface myosin in cultured fibroblasts. Cell. 8: 383-90. PMID 782725 DOI: 10.1016/0092-8674(76)90150-1  0.302
1976 Yamada KM, Yamada SS, Pastan I. Cell surface protein partially restores morphology, adhesiveness, and contact inhibition of movement to transformed fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 73: 1217-21. PMID 177979 DOI: 10.1073/pnas.73.4.1217  0.499
1976 Pouysségur JM, Pastan I. Mutants of Balb/c 3T3 fibroblasts defective in adhesiveness to substratum: evidence for alteration in cell surface proteins. Proceedings of the National Academy of Sciences of the United States of America. 73: 544-8. PMID 174110 DOI: 10.1073/PNAS.73.2.544  0.338
1976 Pastan I. Cyclic AMP and the malignant transformation of cells. Advances in Metabolic Disorders. 8: 377-83. PMID 173162 DOI: 10.1016/B978-0-12-027308-9.50029-9  0.319
1976 Yamada KM, Ohanian SH, Pastan I. Cell surface protein decreases microvilli and ruffles on transformed mouse and chick cells. Cell. 9: 241-5. PMID 61821 DOI: 10.1016/0092-8674(76)90115-X  0.495
1976 Yamada KM, Pastan I. Cell surface protein and neoplastic transformation Trends in Biochemical Sciences. 1: 222-224. DOI: 10.1016/S0968-0004(76)80095-3  0.302
1975 Willingham MC, Pastan I. Cyclic AMP mediates the concanavalin A agglutinability of mouse fibroblasts. The Journal of Cell Biology. 63: 288-94. PMID 4371073 DOI: 10.1083/JCB.63.1.288  0.329
1975 Willingham MC, Pastan I. Cyclic AMP modulates microvillus formation and agglutinability in transformed and normal mouse fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 72: 1263-7. PMID 165501 DOI: 10.1073/PNAS.72.4.1263  0.319
1974 Musso RE, de Crombrugghe B, Pastan I, Sklar J, Yot P, Weissman S. The 5'-terminal nucleotide sequence of galactose messenger ribonucleic acid of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 71: 4940-4. PMID 4612533 DOI: 10.1073/pnas.71.12.4940  0.507
1974 Pastan I, Gallo M, Banderson W. [50] The purification and analysis of mechanism of action of a cyclic AMP-receptor protein from Escherichia coli Methods in Enzymology. 38: 367-376. PMID 4375769 DOI: 10.1016/0076-6879(74)38053-6  0.31
1974 Willingham MC, Ostlund RE, Pastan I. Myosin in a Component of the Cell Surface of Cultured Cells Proceedings of the National Academy of Sciences of the United States of America. 71: 4144-4148. PMID 4372609 DOI: 10.1073/Pnas.71.10.4144  0.314
1974 Pastan I, Johnson GS. Cyclic AMP and the transformation of fibroblasts Advances in Cancer Research. 19: 303-329. PMID 4368553 DOI: 10.1016/S0065-230X(08)60057-3  0.312
1974 Carchman RA, Johnson GS, Pastan I, Scolnick EM. Studies on the levels of cyclic AMP in cells transformed by wild-type and temperature-sensitive Kirsten sarcoma virus Cell. 1: 59-64. DOI: 10.1016/0092-8674(74)90156-1  0.306
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