Deniz Dalkara, Ph.D. - Publications

Affiliations: 
Ophthalmology Institut de la Vision, Paris 
Area:
Gene therapies, animal models for neurodegenerative diseases
Website:
http://www.institut-vision.org/index.php?option=com_content&id=326:equipe-de-deniz-dalkara&Itemid=15&lang=en

71 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Thompson DA, Iannaccone A, Ali RR, Arshavsky VY, Audo I, Bainbridge JWB, Besirli CG, Birch DG, Branham KE, Cideciyan AV, Daiger SP, Dalkara D, Duncan JL, Fahim AT, Flannery JG, et al. Advancing Clinical Trials for Inherited Retinal Diseases: Recommendations from the Second Monaciano Symposium. Translational Vision Science & Technology. 9: 2. PMID 32832209 DOI: 10.1167/tvst.9.7.2  0.96
2020 Ferrari U, Deny S, Sengupta A, Caplette R, Trapani F, Sahel JA, Dalkara D, Picaud S, Duebel J, Marre O. Towards optogenetic vision restoration with high resolution. Plos Computational Biology. 16: e1007857. PMID 32667921 DOI: 10.1371/journal.pcbi.1007857  0.64
2020 Bertin S, Brazhnikova E, Jaillard C, Sahel JA, Dalkara D. AAV-Mediated Gene Delivery to Foveal Cones. Methods in Molecular Biology (Clifton, N.J.). 2173: 101-112. PMID 32651912 DOI: 10.1007/978-1-0716-0755-8_6  0.64
2020 Byrne LC, Day TP, Visel M, Fortuny C, Dalkara D, Merigan WH, Schaffer DV, Flannery JG. In vivo directed evolution of AAV in the primate retina. Jci Insight. PMID 32271719 DOI: 10.1172/jci.insight.135112  0.96
2020 Barboni MTS, Vaillend C, Joachimsthaler A, Liber AMP, Khabou H, Roux MJ, Vacca O, Vignaud L, Dalkara D, Guillonneau X, Ventura DF, Rendon A, Kremers J. Rescue of Defective Electroretinographic Responses in Dp71-Null Mice With AAV-Mediated Reexpression of Dp71. Investigative Ophthalmology & Visual Science. 61: 11. PMID 32049345 DOI: 10.1167/iovs.61.2.11  1
2020 Garita-Hernandez M, Routet F, Guibbal L, Khabou H, Toualbi L, Riancho L, Reichman S, Duebel J, Sahel JA, Goureau O, Dalkara D. AAV-Mediated Gene Delivery to 3D Retinal Organoids Derived from Human Induced Pluripotent Stem Cells. International Journal of Molecular Sciences. 21. PMID 32028585 DOI: 10.3390/ijms21030994  1
2020 Simon CJ, Sahel JA, Duebel J, Herlitze S, Dalkara D. Opsins for vision restoration. Biochemical and Biophysical Research Communications. PMID 31982136 DOI: 10.1016/j.bbrc.2019.12.117  0.64
2019 Picaud S, Dalkara D, Marazova K, Goureau O, Roska B, Sahel JA. The primate model for understanding and restoring vision. Proceedings of the National Academy of Sciences of the United States of America. PMID 31871177 DOI: 10.1073/pnas.1902292116  0.64
2019 Garita-Hernandez M, Lampič M, Chaffiol A, Guibbal L, Routet F, Santos-Ferreira T, Gasparini S, Borsch O, Gagliardi G, Reichman S, Picaud S, Sahel JA, Goureau O, Ader M, Dalkara D, et al. Restoration of visual function by transplantation of optogenetically engineered photoreceptors. Nature Communications. 10: 4524. PMID 31586094 DOI: 10.1038/s41467-019-12330-2  0.64
2019 Sahel JA, Dalkara D. Gene therapy for retinal dystrophy. Nature Medicine. 25: 198-199. PMID 30718907 DOI: 10.1038/s41591-019-0346-1  0.64
2018 Garita-Hernandez M, Guibbal L, Toualbi L, Routet F, Chaffiol A, Winckler C, Harinquet M, Robert C, Fouquet S, Bellow S, Sahel JA, Goureau O, Duebel J, Dalkara D. Optogenetic Light Sensors in Human Retinal Organoids. Frontiers in Neuroscience. 12: 789. PMID 30450028 DOI: 10.3389/fnins.2018.00789  0.64
2018 Quinn PM, Mulder AA, Henrique Alves C, Desrosiers M, Vries SI, Klooster J, Dalkara D, Koster AJ, Jost CR, Wijnholds J. Loss of CRB2 in Müller glial cells modifies a CRB1-associated retinitis pigmentosa phenotype into a Leber congenital amaurosis phenotype. Human Molecular Genetics. PMID 30239717 DOI: 10.1093/hmg/ddy337  0.32
2018 Khabou H, Cordeau C, Pacot L, Fisson S, Dalkara D. Dosage thresholds and influence of transgene cassette in AAV-related toxicity. Human Gene Therapy. PMID 30132368 DOI: 10.1089/hum.2018.144  1
2018 Khabou H, Garita-Hernandez M, Chaffiol A, Reichman S, Jaillard C, Brazhnikova E, Bertin S, Forster V, Desrosiers M, Winckler C, Goureau O, Picaud S, Duebel J, Sahel JA, Dalkara D. Noninvasive gene delivery to foveal cones for vision restoration. Jci Insight. 3. PMID 29367457 DOI: 10.1172/jci.insight.96029  1
2018 Desrosiers M, Dalkara D. Neutralizing Antibodies Against Adeno-Associated Virus (AAV): Measurement and Influence on Retinal Gene Delivery. Methods in Molecular Biology (Clifton, N.J.). 1715: 225-238. PMID 29188517 DOI: 10.1007/978-1-4939-7522-8_16  0.32
2017 Joly S, Dalkara D, Pernet V. Sphingosine 1-Phosphate Receptor 1 Modulates CNTF-Induced Axonal Growth and Neuroprotection in the Mouse Visual System. Neural Plasticity. 2017: 6818970. PMID 29234527 DOI: 10.1155/2017/6818970  0.32
2017 Chaffiol A, Caplette R, Jaillard C, Brazhnikova E, Desrosiers M, Dubus E, Duhamel L, Macé E, Marre O, Benoit P, Hantraye P, Bemelmans AP, Bamberg E, Duebel J, Sahel JA, ... ... Dalkara D, et al. A New Promoter Allows Optogenetic Vision Restoration with Enhanced Sensitivity in Macaque Retina. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 28807567 DOI: 10.1016/j.ymthe.2017.07.011  0.64
2016 Scholl HP, Strauss RW, Singh MS, Dalkara D, Roska B, Picaud S, Sahel JA. Emerging therapies for inherited retinal degeneration. Science Translational Medicine. 8: 368rv6. PMID 27928030 DOI: 10.1126/scitranslmed.aaf2838  0.64
2016 Khabou H, Desrosiers M, Winckler C, Fouquet S, Auregan G, Bemelmans AP, Sahel JA, Dalkara D. Cover Image, Volume 113, Number 12, December 2016. Biotechnology and Bioengineering. 113: i. PMID 27788308 DOI: 10.1002/bit.25806  1
2016 Sengupta A, Chaffiol A, Macé E, Caplette R, Desrosiers M, Lampič M, Forster V, Marre O, Lin JY, Sahel JA, Picaud S, Dalkara D, Duebel J. Red-shifted channelrhodopsin stimulation restores light responses in blind mice, macaque retina, and human retina. Embo Molecular Medicine. PMID 27679671 DOI: 10.15252/emmm.201505699  1
2016 Vacca O, Charles-Messance H, El Mathari B, Sene A, Barbe P, Fouquet S, Aragón J, Darche M, Giocanti-Aurégan A, Paques M, Sahel JA, Tadayoni R, Montañez C, Dalkara D, Rendon A. AAV-mediated gene therapy in Dystrophin-Dp71 deficient mouse leads to blood-retinal barrier restoration and edema reabsorption. Human Molecular Genetics. PMID 27288449 DOI: 10.1093/hmg/ddw159  0.64
2016 Khabou H, Desrosiers M, Winckler C, Fouquet S, Auregan G, Bemelmans AP, Sahel JA, Dalkara D. Insight into the mechanisms of enhanced retinal transduction by the engineered AAV2 capsid variant -7m8. Biotechnology and Bioengineering. PMID 27259396 DOI: 10.1002/bit.26031  1
2016 Spoida K, Eickelbeck D, Karapinar R, Eckhardt T, Mark MD, Jancke D, Ehinger BV, König P, Dalkara D, Herlitze S, Masseck OA. Melanopsin Variants as Intrinsic Optogenetic On and Off Switches for Transient versus Sustained Activation of G Protein Pathways. Current Biology : Cb. PMID 27068418 DOI: 10.1016/j.cub.2016.03.007  1
2016 Mei X, Chaffiol A, Kole C, Yang Y, Millet-Puel G, Clérin E, Aït-Ali N, Bennett J, Dalkara D, Sahel JA, Duebel J, Leveillard T. The thioredoxin encoded by the Rod-derived Cone Viability Factor gene protects cone photoreceptors against oxidative stress. Antioxidants & Redox Signaling. PMID 27025156 DOI: 10.1089/ars.2015.6509  0.64
2016 Dalkara D, Goureau O, Marazova K, Sahel JA. Let there be light: gene and cell therapy for blindness. Human Gene Therapy. PMID 26751519 DOI: 10.1089/hum.2015.147  1
2016 Dalkara D. Smart CRISPR-Cas9 liver delivery repairs a genetic defect Science Translational Medicine. 8. DOI: 10.1126/scitranslmed.aaf3854  1
2016 Dalkara D. Stem cells lead the blind Science Translational Medicine. 8. DOI: 10.1126/scitranslmed.aaf0858  1
2015 Mark MD, Krause M, Boele HJ, Kruse W, Pollok S, Kuner T, Dalkara D, Koekkoek S, De Zeeuw CI, Herlitze S. Spinocerebellar Ataxia Type 6 Protein Aggregates Cause Deficits in Motor Learning and Cerebellar Plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 8882-95. PMID 26063920 DOI: 10.1523/JNEUROSCI.0891-15.2015  1
2015 Khabou H, Dalkara D. [Developments in gene delivery vectors for ocular gene therapy]. MéDecine Sciences : M/S. 31: 529-37. PMID 26059304 DOI: 10.1051/medsci/20153105015  1
2015 Orhan E, Dalkara D, Neuillé M, Lechauve C, Michiels C, Picaud S, Léveillard T, Sahel JA, Naash MI, Lavail MM, Zeitz C, Audo I. Genotypic and phenotypic characterization of P23H line 1 rat model. Plos One. 10: e0127319. PMID 26009893 DOI: 10.1371/journal.pone.0127319  1
2015 Aït-Ali N, Fridlich R, Millet-Puel G, Clérin E, Delalande F, Jaillard C, Blond F, Perrocheau L, Reichman S, Byrne LC, Olivier-Bandini A, Bellalou J, Moyse E, Bouillaud F, Nicol X, ... Dalkara D, et al. Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis. Cell. 161: 817-32. PMID 25957687 DOI: 10.1016/j.cell.2015.03.023  0.72
2015 Vacca O, El Mathari B, Darche M, Sahel JA, Rendon A, Dalkara D. Using Adeno-associated Virus as a Tool to Study Retinal Barriers in Disease. Journal of Visualized Experiments : Jove. PMID 25938717 DOI: 10.3791/52451  1
2015 Dalkara D, Duebel J, Sahel JA. Gene therapy for the eye focus on mutation-independent approaches. Current Opinion in Neurology. 28: 51-60. PMID 25545056 DOI: 10.1097/WCO.0000000000000168  1
2015 Byrne LC, Dalkara D, Luna G, Fisher SK, Clérin E, Sahel JA, Léveillard T, Flannery JG. Viral-mediated RdCVF and RdCVFL expression protects cone and rod photoreceptors in retinal degeneration. The Journal of Clinical Investigation. 125: 105-16. PMID 25415434 DOI: 10.1172/JCI65654  1
2015 Vajda F, Jordi N, Dalkara D, Joly S, Christ F, Tews B, Schwab ME, Pernet V. Cell type-specific Nogo-A gene ablation promotes axonal regeneration in the injured adult optic nerve. Cell Death and Differentiation. 22: 323-35. PMID 25257170 DOI: 10.1038/cdd.2014.147  1
2015 Macé E, Caplette R, Marre O, Sengupta A, Chaffiol A, Barbe P, Desrosiers M, Bamberg E, Sahel JA, Picaud S, Duebel J, Dalkara D. Targeting channelrhodopsin-2 to ON-bipolar cells with vitreally administered AAV Restores ON and OFF visual responses in blind mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 23: 7-16. PMID 25095892 DOI: 10.1038/mt.2014.154  1
2015 Dalkara D. Muscle memory helps with heartache Science Translational Medicine. 7. DOI: 10.1126/scitranslmed.aad8020  1
2015 Dalkara D. Gene therapy hide and seek Science Translational Medicine. 7. DOI: 10.1126/scitranslmed.aad4447  1
2015 Dalkara D. Boosting the success of retinal gene therapy Science Translational Medicine. 7. DOI: 10.1126/scitranslmed.aad3065  1
2015 Dalkara D. Cutting down on sense makes sense for gene silencing Science Translational Medicine. 7. DOI: 10.1126/scitranslmed.aac9738  1
2015 Dalkara D. Baby steps in gene therapy Science Translational Medicine. 7. DOI: 10.1126/scitranslmed.aac7151  1
2015 Dalkara D. AAV and gene therapy: It's complicated Science Translational Medicine. 7. DOI: 10.1126/scitranslmed.aab3969  1
2015 Aït-Ali N, Fridlich R, Millet-Puel G, Clérin E, Delalande F, Jaillard C, Blond F, Perrocheau L, Reichman S, Byrne LC, Olivier-Bandini A, Bellalou J, Moyse E, Bouillaud F, Nicol X, ... Dalkara D, et al. Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis Cell. 161: 817-832. DOI: 10.1016/j.cell.2015.03.023  1
2014 Bockstael O, Tenenbaum L, Dalkara D, Melas C, De Witte O, Levivier M, Chtarto A. Intracisternal delivery of NFκB-inducible scAAV2/9 reveals locoregional neuroinflammation induced by systemic kainic acid treatment. Frontiers in Molecular Neuroscience. 7: 92. PMID 25520614 DOI: 10.3389/fnmol.2014.00092  1
2014 Yin L, Masella B, Dalkara D, Zhang J, Flannery JG, Schaffer DV, Williams DR, Merigan WH. Imaging light responses of foveal ganglion cells in the living macaque eye. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 6596-605. PMID 24806684 DOI: 10.1523/JNEUROSCI.4438-13.2014  1
2014 Dalkara D, Sahel JA. Gene therapy for inherited retinal degenerations. Comptes Rendus Biologies. 337: 185-92. PMID 24702845 DOI: 10.1016/j.crvi.2014.01.002  1
2014 Byrne LC, Oztürk BE, Lee T, Fortuny C, Visel M, Dalkara D, Schaffer DV, Flannery JG. Retinoschisin gene therapy in photoreceptors, Müller glia or all retinal cells in the Rs1h-/- mouse. Gene Therapy. 21: 585-92. PMID 24694538 DOI: 10.1038/gt.2014.31  1
2014 Masseck OA, Spoida K, Dalkara D, Maejima T, Rubelowski JM, Wallhorn L, Deneris ES, Herlitze S. Vertebrate cone opsins enable sustained and highly sensitive rapid control of Gi/o signaling in anxiety circuitry. Neuron. 81: 1263-73. PMID 24656249 DOI: 10.1016/j.neuron.2014.01.041  1
2014 Vacca O, Darche M, Schaffer DV, Flannery JG, Sahel JA, Rendon A, Dalkara D. AAV-mediated gene delivery in Dp71-null mouse model with compromised barriers. Glia. 62: 468-76. PMID 24382652 DOI: 10.1002/glia.22617  1
2013 Pernet V, Joly S, Jordi N, Dalkara D, Guzik-Kornacka A, Flannery JG, Schwab ME. Misguidance and modulation of axonal regeneration by Stat3 and Rho/ROCK signaling in the transparent optic nerve. Cell Death & Disease. 4: e734. PMID 23868067 DOI: 10.1038/cddis.2013.266  1
2013 Dalkara D, Byrne LC, Klimczak RR, Visel M, Yin L, Merigan WH, Flannery JG, Schaffer DV. In vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous. Science Translational Medicine. 5: 189ra76. PMID 23761039 DOI: 10.1126/scitranslmed.3005708  1
2013 Sahel JA, Léveillard T, Picaud S, Dalkara D, Marazova K, Safran A, Paques M, Duebel J, Roska B, Mohand-Said S. Functional rescue of cone photoreceptors in retinitis pigmentosa. Graefe's Archive For Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv FüR Klinische Und Experimentelle Ophthalmologie. 251: 1669-77. PMID 23575948 DOI: 10.1007/s00417-013-2314-7  1
2013 Pernet V, Joly S, Dalkara D, Jordi N, Schwarz O, Christ F, Schaffer DV, Flannery JG, Schwab ME. Long-distance axonal regeneration induced by CNTF gene transfer is impaired by axonal misguidance in the injured adult optic nerve. Neurobiology of Disease. 51: 202-13. PMID 23194670 DOI: 10.1016/j.nbd.2012.11.011  1
2013 Yin L, Masella BD, Geng Y, Dalkara D, Osakada F, Sharma R, Zhang J, Cetin AH, Callaway EM, Flannery JG, Schaffer DV, Williams DR, Merigan WH. Optical recording of the light response of ganglion cells in the living eye Optics Infobase Conference Papers 1
2012 Dehay B, Dalkara D, Dovero S, Li Q, Bezard E. Systemic scAAV9 variant mediates brain transduction in newborn rhesus macaques. Scientific Reports. 2: 253. PMID 22355765 DOI: 10.1038/srep00253  1
2012 Mourot A, Fehrentz T, Le Feuvre Y, Smith CM, Herold C, Dalkara D, Nagy F, Trauner D, Kramer RH. Rapid optical control of nociception with an ion-channel photoswitch. Nature Methods. 9: 396-402. PMID 22343342 DOI: 10.1038/nmeth.1897  1
2012 Pernet V, Joly S, Dalkara D, Schwarz O, Christ F, Schaffer D, Flannery JG, Schwab ME. Neuronal Nogo-A upregulation does not contribute to ER stress-associated apoptosis but participates in the regenerative response in the axotomized adult retina. Cell Death and Differentiation. 19: 1096-108. PMID 22193546 DOI: 10.1038/cdd.2011.191  1
2012 Dalkara D, Byrne LC, Lee T, Hoffmann NV, Schaffer DV, Flannery JG. Enhanced gene delivery to the neonatal retina through systemic administration of tyrosine-mutated AAV9. Gene Therapy. 19: 176-81. PMID 22011645 DOI: 10.1038/gt.2011.163  1
2012 Dalkara D. Gene therapy explodes in ophthalmology | La thérapie génique explose en ophtalmologie Biofutur. 38-42.  1
2011 Caporale N, Kolstad KD, Lee T, Tochitsky I, Dalkara D, Trauner D, Kramer R, Dan Y, Isacoff EY, Flannery JG. LiGluR restores visual responses in rodent models of inherited blindness. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 1212-9. PMID 21610698 DOI: 10.1038/mt.2011.103  1
2011 Dalkara D, Kolstad KD, Guerin KI, Hoffmann NV, Visel M, Klimczak RR, Schaffer DV, Flannery JG. AAV mediated GDNF secretion from retinal glia slows down retinal degeneration in a rat model of retinitis pigmentosa. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 1602-8. PMID 21522134 DOI: 10.1038/mt.2011.62  1
2011 Yin L, Greenberg K, Hunter JJ, Dalkara D, Kolstad KD, Masella BD, Wolfe R, Visel M, Stone D, Libby RT, Diloreto D, Schaffer D, Flannery J, Williams DR, Merigan WH. Intravitreal injection of AAV2 transduces macaque inner retina. Investigative Ophthalmology & Visual Science. 52: 2775-83. PMID 21310920 DOI: 10.1167/iovs.10-6250  1
2010 Kolstad KD, Dalkara D, Guerin K, Visel M, Hoffmann N, Schaffer DV, Flannery JG. Changes in adeno-associated virus-mediated gene delivery in retinal degeneration. Human Gene Therapy. 21: 571-8. PMID 20021232 DOI: 10.1089/hum.2009.194  1
2009 Klimczak RR, Koerber JT, Dalkara D, Flannery JG, Schaffer DV. A novel adeno-associated viral variant for efficient and selective intravitreal transduction of rat Müller cells. Plos One. 4: e7467. PMID 19826483 DOI: 10.1371/journal.pone.0007467  1
2009 Dalkara D, Kolstad KD, Caporale N, Visel M, Klimczak RR, Schaffer DV, Flannery JG. Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 2096-102. PMID 19672248 DOI: 10.1038/mt.2009.181  1
2009 Koerber JT, Klimczak R, Jang JH, Dalkara D, Flannery JG, Schaffer DV. Molecular evolution of adeno-associated virus for enhanced glial gene delivery. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 2088-95. PMID 19672246 DOI: 10.1038/mt.2009.184  1
2007 Courtête J, Sibler AP, Zeder-Lutz G, Dalkara D, Oulad-Abdelghani M, Zuber G, Weiss E. Suppression of cervical carcinoma cell growth by intracytoplasmic codelivery of anti-oncoprotein E6 antibody and small interfering RNA. Molecular Cancer Therapeutics. 6: 1728-35. PMID 17575104 DOI: 10.1158/1535-7163.MCT-06-0808  1
2007 Chittimalla C, Dalkara D, Zuber G. Design, synthesis and evaluation of a novel polymer for gene delivery to mammalian cells Letters in Drug Design and Discovery. 4: 92-98. DOI: 10.2174/157018007779422569  1
2006 Dalkara D, Chandrashekhar C, Zuber G. Intracellular protein delivery with a dimerizable amphiphile for improved complex stability and prolonged protein release in the cytoplasm of adherent cell lines. Journal of Controlled Release : Official Journal of the Controlled Release Society. 116: 353-9. PMID 17097756 DOI: 10.1016/j.jconrel.2006.10.005  1
2006 Fraley AW, Pons B, Dalkara D, Nullans G, Behr JP, Zuber G. Cationic oligonucleotide-peptide conjugates with aggregating properties enter efficiently into cells while maintaining hybridization properties and enzymatic recognition. Journal of the American Chemical Society. 128: 10763-71. PMID 16910671 DOI: 10.1021/ja060873e  1
2004 Dalkara D, Zuber G, Behr JP. Intracytoplasmic delivery of anionic proteins. Molecular Therapy : the Journal of the American Society of Gene Therapy. 9: 964-9. PMID 15194063 DOI: 10.1016/j.ymthe.2004.03.007  1
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