Lea Sistonen - Publications

Affiliations: 
1990-1993 Abo Akademi University, Finland 

104 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Mayer MP, Blair L, Blatch GL, Borges TJ, Chadli A, Chiosis G, de Thonel A, Dinkova-Kostova A, Ecroyd H, Edkins AL, Eguchi T, Fleshner M, Foley KP, Fragkostefanakis S, Gestwicki J, ... ... Sistonen L, et al. Stress Biology: Complexity and Multifariousness in Health and Disease. Cell Stress & Chaperones. PMID 38311120 DOI: 10.1016/j.cstres.2024.01.006  0.782
2023 Pessa JC, Joutsen J, Sistonen L. Transcriptional reprogramming at the intersection of the heat shock response and proteostasis. Molecular Cell. 84: 80-93. PMID 38103561 DOI: 10.1016/j.molcel.2023.11.024  0.478
2023 de Thonel A, Ahlskog JK, Daupin K, Dubreuil V, Berthelet J, Chaput C, Pires G, Leonetti C, Abane R, Barris LC, Leray I, Aalto AL, Naceri S, Cordonnier M, Benasolo C, ... ... Sistonen L, et al. Author Correction: CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder. Nature Communications. 14: 6067. PMID 37770591 DOI: 10.1038/s41467-023-41869-4  0.606
2023 van Oosten-Hawle P, Backe SJ, Ben-Zvi A, Bourboulia D, Brancaccio M, Brodsky J, Clark M, Colombo G, Cox MB, De Los Rios P, Echtenkamp F, Edkins A, Freeman B, Goloubinoff P, Houry W, ... ... Sistonen L, et al. Second Virtual International Symposium on Cellular and Organismal Stress Responses, September 8-9, 2022. Cell Stress & Chaperones. PMID 36602710 DOI: 10.1007/s12192-022-01318-5  0.74
2022 de Thonel A, Ahlskog JK, Daupin K, Dubreuil V, Berthelet J, Chaput C, Pires G, Leonetti C, Abane R, Barris LC, Leray I, Aalto AL, Naceri S, Cordonnier M, Benasolo C, ... ... Sistonen L, et al. CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder. Nature Communications. 13: 7002. PMID 36385105 DOI: 10.1038/s41467-022-34476-2  0.715
2022 Himanen SV, Puustinen MC, Da Silva AJ, Vihervaara A, Sistonen L. HSFs drive transcription of distinct genes and enhancers during oxidative stress and heat shock. Nucleic Acids Research. PMID 35687139 DOI: 10.1093/nar/gkac493  0.444
2021 Roos-Mattjus P, Sistonen L. Interplay between mammalian heat shock factors 1 and 2 in physiology and pathology. The Febs Journal. PMID 34478606 DOI: 10.1111/febs.16178  0.34
2021 Lior C, Hodge F, De-Souza EA, Bourboulia D, Calderwood SK, David D, Allan Drummond D, Edkins A, Morimoto RI, Prahlad V, Rechavi O, Sistonen L, Wilson M, Wiseman RL, Zanetti M, et al. The 2021 FASEB Virtual Catalyst Conference on Extracellular and Organismal Proteostasis in Health and Disease, February 3-4, 2021. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 35: e21631. PMID 34046940 DOI: 10.1096/fj.202100566  0.672
2021 Vihervaara A, Mahat DB, Himanen SV, Blom MAH, Lis JT, Sistonen L. Stress-induced transcriptional memory accelerates promoter-proximal pause release and decelerates termination over mitotic divisions. Molecular Cell. 81: 1715-1731.e6. PMID 33784494 DOI: 10.1016/j.molcel.2021.03.007  0.396
2020 Puustinen MC, Sistonen L. Molecular Mechanisms of Heat Shock Factors in Cancer. Cells. 9. PMID 32408596 DOI: 10.3390/Cells9051202  0.476
2020 Joutsen J, Da Silva AJ, Luoto JC, Budzynski MA, Nylund AS, de Thonel A, Concordet JP, Mezger V, Sabéran-Djoneidi D, Henriksson E, Sistonen L. Heat Shock Factor 2 Protects against Proteotoxicity by Maintaining Cell-Cell Adhesion. Cell Reports. 30: 583-597.e6. PMID 31940498 DOI: 10.1016/J.Celrep.2019.12.037  0.538
2019 Himanen SV, Sistonen L. New insights into transcriptional reprogramming during cellular stress. Journal of Cell Science. 132. PMID 31676663 DOI: 10.1242/Jcs.238402  0.501
2019 Baker-Williams AJ, Hashmi F, Budzyński MA, Woodford MR, Gleicher S, Himanen SV, Makedon AM, Friedman D, Cortes S, Namek S, Stetler-Stevenson WG, Bratslavsky G, Bah A, Mollapour M, Sistonen L, et al. Co-chaperones TIMP2 and AHA1 Competitively Regulate Extracellular HSP90:Client MMP2 Activity and Matrix Proteolysis. Cell Reports. 28: 1894-1906.e6. PMID 31412254 DOI: 10.1016/J.Celrep.2019.07.045  0.329
2019 Joutsen J, Sistonen L. Tailoring of Proteostasis Networks with Heat Shock Factors. Cold Spring Harbor Perspectives in Biology. 11. PMID 30420555 DOI: 10.1101/Cshperspect.A034066  0.518
2018 Kijima T, Prince TL, Tigue ML, Yim KH, Schwartz H, Beebe K, Lee S, Budzynski MA, Williams H, Trepel JB, Sistonen L, Calderwood S, Neckers L. HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation. Scientific Reports. 8: 6976. PMID 29725069 DOI: 10.1038/S41598-018-25404-W  0.528
2018 Bonorino C, Sistonen L, Eriksson J, Mezger V, Santoro G, Hightower LE. The VIII International Congress on Stress Proteins in Biology and Medicine: täynnä henkeä. Cell Stress & Chaperones. PMID 29396663 DOI: 10.1007/S12192-018-0878-1  0.386
2018 Antila CJM, Rraklli V, Blomster HA, Dahlström KM, Salminen TA, Holmberg J, Sistonen L, Sahlgren C. Sumoylation of Notch1 represses its target gene expression during cell stress. Cell Death and Differentiation. 25: 600-615. PMID 29305585 DOI: 10.1038/S41418-017-0002-6  0.456
2018 Tigue ML, Kijima T, Prince TL, Yim KH, Schwartz H, Beebe K, Lee S, Budzynski MA, Williams H, Trepel JB, Sistonen L, Calderwood S, Neckers L. Abstract 446: HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation Cancer Research. 78: 446-446. DOI: 10.1158/1538-7445.Am2018-446  0.513
2017 Vihervaara A, Mahat DB, Guertin MJ, Chu T, Danko CG, Lis JT, Sistonen L. Transcriptional response to stress is pre-wired by promoter and enhancer architecture. Nature Communications. 8: 255. PMID 28811569 DOI: 10.1038/S41467-017-00151-0  0.497
2017 Budzyński MA, Crul T, Himanen SV, Toth N, Otvos F, Sistonen L, Vigh L. Chaperone co-inducer BGP-15 inhibits histone deacetylases and enhances the heat shock response through increased chromatin accessibility. Cell Stress & Chaperones. PMID 28474205 DOI: 10.1007/S12192-017-0798-5  0.536
2016 Karvinen S, Silvennoinen M, Vainio P, Sistonen L, Koch LG, Britton SL, Kainulainen H. Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins. Experimental Gerontology. PMID 27038700 DOI: 10.1016/J.Exger.2016.03.015  0.42
2016 Jaeger AM, Pemble CW, Sistonen L, Thiele DJ. Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors. Nature Structural & Molecular Biology. 23: 147-54. PMID 26727490 DOI: 10.1038/Nsmb.3150  0.477
2016 Björk JK, Åkerfelt M, Joutsen J, Puustinen MC, Cheng F, Sistonen L, Nees M. Heat-shock factor 2 is a suppressor of prostate cancer invasion. Oncogene. 35: 1770-84. PMID 26119944 DOI: 10.1038/Onc.2015.241  0.393
2015 Niskanen EA, Malinen M, Sutinen P, Toropainen S, Paakinaho V, Vihervaara A, Joutsen J, Kaikkonen MU, Sistonen L, Palvimo JJ. Global SUMOylation on active chromatin is an acute heat stress response restricting transcription. Genome Biology. 16: 153. PMID 26259101 DOI: 10.1186/S13059-015-0717-Y  0.527
2015 Budzyński MA, Puustinen MC, Joutsen J, Sistonen L. Uncoupling Stress-Inducible Phosphorylation of Heat Shock Factor 1 from Its Activation. Molecular and Cellular Biology. 35: 2530-40. PMID 25963659 DOI: 10.1128/Mcb.00816-14  0.524
2015 Swan CL, Sistonen L. Cellular stress response cross talk maintains protein and energy homeostasis. The Embo Journal. 34: 267-9. PMID 25555794 DOI: 10.15252/Embj.201490757  0.464
2014 Elsing AN, Aspelin C, Björk JK, Bergman HA, Himanen SV, Kallio MJ, Roos-Mattjus P, Sistonen L. Expression of HSF2 decreases in mitosis to enable stress-inducible transcription and cell survival. The Journal of Cell Biology. 206: 735-49. PMID 25202032 DOI: 10.1083/Jcb.201402002  0.539
2014 Morano KA, Sistonen L, Mezger V. Heat shock in the springtime. Cell Stress & Chaperones. 19: 753-61. PMID 25199949 DOI: 10.1007/S12192-014-0539-Y  0.52
2014 Vihervaara A, Sistonen L. HSF1 at a glance. Journal of Cell Science. 127: 261-6. PMID 24421309 DOI: 10.1242/Jcs.132605  0.544
2013 Vihervaara A, Sergelius C, Vasara J, Blom MA, Elsing AN, Roos-Mattjus P, Sistonen L. Transcriptional response to stress in the dynamic chromatin environment of cycling and mitotic cells. Proceedings of the National Academy of Sciences of the United States of America. 110: E3388-97. PMID 23959860 DOI: 10.1073/Pnas.1305275110  0.504
2013 Åkerfelt M, Björk J, Mirtti T, Fey V, Sistonen L, Nees M. Abstract A46: Opposing effects of heat shock factors 1 and 2 on prostate cancer invasion Cancer Research. 73. DOI: 10.1158/1538-7445.Tim2013-A46  0.377
2012 Sundvall M, Korhonen A, Vaparanta K, Anckar J, Halkilahti K, Salah Z, Aqeilan RI, Palvimo JJ, Sistonen L, Elenius K. Protein inhibitor of activated STAT3 (PIAS3) protein promotes SUMOylation and nuclear sequestration of the intracellular domain of ErbB4 protein. The Journal of Biological Chemistry. 287: 23216-26. PMID 22584572 DOI: 10.1074/Jbc.M111.335927  0.369
2011 Anckar J, Sistonen L. Regulation of HSF1 function in the heat stress response: implications in aging and disease. Annual Review of Biochemistry. 80: 1089-115. PMID 21417720 DOI: 10.1146/Annurev-Biochem-060809-095203  0.576
2011 Korhonen A, Sundvall M, Vaparanta K, Anckar J, Halkilahti K, Salah Z, Aqeilan R, Palvimo JJ, Sistonen L, Elenius K. Abstract B182: Nuclear sequestration of ErbB4 receptor tyrosine kinase by PIAS3. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-B182  0.329
2011 Petre I, Mizera A, Hyder CL, Meinander A, Mikhailov A, Morimoto RI, Sistonen L, Eriksson JE, Back RJ. A simple mass-action model for the eukaryotic heat shock response and its mathematical validation Natural Computing. 10: 595-612. DOI: 10.1007/S11047-010-9216-Y  0.649
2010 Björk JK, Sistonen L. Regulation of the members of the mammalian heat shock factor family. The Febs Journal. 277: 4126-39. PMID 20945529 DOI: 10.1111/J.1742-4658.2010.07828.X  0.58
2010 Ahlskog JK, Björk JK, Elsing AN, Aspelin C, Kallio M, Roos-Mattjus P, Sistonen L. Anaphase-promoting complex/cyclosome participates in the acute response to protein-damaging stress. Molecular and Cellular Biology. 30: 5608-20. PMID 20937767 DOI: 10.1128/Mcb.01506-09  0.546
2010 Akerfelt M, Vihervaara A, Laiho A, Conter A, Christians ES, Sistonen L, Henriksson E. Heat shock transcription factor 1 localizes to sex chromatin during meiotic repression. The Journal of Biological Chemistry. 285: 34469-76. PMID 20802198 DOI: 10.1074/Jbc.M110.157552  0.442
2010 Akerfelt M, Morimoto RI, Sistonen L. Heat shock factors: integrators of cell stress, development and lifespan. Nature Reviews. Molecular Cell Biology. 11: 545-55. PMID 20628411 DOI: 10.1038/Nrm2938  0.689
2009 Vuori KA, Ahlskog JK, Sistonen L, Nikinmaa M. TransLISA, a novel quantitative, nonradioactive assay for transcription factor DNA-binding analyses. The Febs Journal. 276: 7366-74. PMID 19912339 DOI: 10.1111/J.1742-4658.2009.07446.X  0.379
2009 Westerheide SD, Anckar J, Stevens SM, Sistonen L, Morimoto RI. Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science (New York, N.Y.). 323: 1063-6. PMID 19229036 DOI: 10.1126/Science.1165946  0.798
2009 Metchat A, Akerfelt M, Bierkamp C, Delsinne V, Sistonen L, Alexandre H, Christians ES. Mammalian heat shock factor 1 is essential for oocyte meiosis and directly regulates Hsp90alpha expression. The Journal of Biological Chemistry. 284: 9521-8. PMID 19158073 DOI: 10.1074/Jbc.M808819200  0.524
2009 Sandqvist A, Björk JK, Akerfelt M, Chitikova Z, Grichine A, Vourc'h C, Jolly C, Salminen TA, Nymalm Y, Sistonen L. Heterotrimerization of heat-shock factors 1 and 2 provides a transcriptional switch in response to distinct stimuli. Molecular Biology of the Cell. 20: 1340-7. PMID 19129477 DOI: 10.1091/Mbc.E08-08-0864  0.54
2008 Akerfelt M, Henriksson E, Laiho A, Vihervaara A, Rautoma K, Kotaja N, Sistonen L. Promoter ChIP-chip analysis in mouse testis reveals Y chromosome occupancy by HSF2. Proceedings of the National Academy of Sciences of the United States of America. 105: 11224-9. PMID 18682557 DOI: 10.1073/Pnas.0800620105  0.388
2007 Akerfelt M, Trouillet D, Mezger V, Sistonen L. Heat shock factors at a crossroad between stress and development. Annals of the New York Academy of Sciences. 1113: 15-27. PMID 17483205 DOI: 10.1196/Annals.1391.005  0.58
2007 Nagy E, Balogi Z, Gombos I, Akerfelt M, Björkbom A, Balogh G, Török Z, Maslyanko A, Fiszer-Kierzkowska A, Lisowska K, Slotte PJ, Sistonen L, Horváth I, Vígh L. Hyperfluidization-coupled membrane microdomain reorganization is linked to activation of the heat shock response in a murine melanoma cell line. Proceedings of the National Academy of Sciences of the United States of America. 104: 7945-50. PMID 17470815 DOI: 10.1073/Pnas.0702557104  0.466
2007 Meinander A, Söderström TS, Kaunisto A, Poukkula M, Sistonen L, Eriksson JE. Fever-like hyperthermia controls T Lymphocyte persistence by inducing degradation of cellular FLIPshort. Journal of Immunology (Baltimore, Md. : 1950). 178: 3944-53. PMID 17339495 DOI: 10.4049/Jimmunol.178.6.3944  0.41
2007 Ostling P, Björk JK, Roos-Mattjus P, Mezger V, Sistonen L. Heat shock factor 2 (HSF2) contributes to inducible expression of hsp genes through interplay with HSF1. The Journal of Biological Chemistry. 282: 7077-86. PMID 17213196 DOI: 10.1074/Jbc.M607556200  0.594
2007 Anckar J, Sistonen L. Heat shock factor 1 as a coordinator of stress and developmental pathways. Advances in Experimental Medicine and Biology. 594: 78-88. PMID 17205677 DOI: 10.1007/978-0-387-39975-1_8  0.57
2006 Chang Y, Ostling P, Akerfelt M, Trouillet D, Rallu M, Gitton Y, El Fatimy R, Fardeau V, Le Crom S, Morange M, Sistonen L, Mezger V. Role of heat-shock factor 2 in cerebral cortex formation and as a regulator of p35 expression. Genes & Development. 20: 836-47. PMID 16600913 DOI: 10.1101/Gad.366906  0.362
2006 Björk JK, Sistonen L. Clustering of heat-shock factors. The Biochemical Journal. 395: e5-6. PMID 16541486 DOI: 10.1042/Bj20060071  0.501
2006 Anckar J, Hietakangas V, Denessiouk K, Thiele DJ, Johnson MS, Sistonen L. Inhibition of DNA binding by differential sumoylation of heat shock factors. Molecular and Cellular Biology. 26: 955-64. PMID 16428449 DOI: 10.1128/Mcb.26.3.955-964.2006  0.429
2006 Hietakangas V, Anckar J, Blomster HA, Fujimoto M, Palvimo JJ, Nakai A, Sistonen L. PDSM, a motif for phosphorylation-dependent SUMO modification. Proceedings of the National Academy of Sciences of the United States of America. 103: 45-50. PMID 16371476 DOI: 10.1073/Pnas.0503698102  0.609
2005 Concannon CG, FitzGerald U, Holmberg CI, Szegezdi E, Sistonen L, Samali A. CD95-mediated alteration in Hsp70 levels is dependent on protein stabilization. Cell Stress & Chaperones. 10: 59-65. PMID 15832948 DOI: 10.1379/Csc-69R.1  0.409
2004 Roos-Mattjus P, Sistonen L. The ubiquitin-proteasome pathway. Annals of Medicine. 36: 285-95. PMID 15224655 DOI: 10.1080/07853890310016324  0.329
2004 Sandqvist A, Sistonen L. Nuclear stress granules: the awakening of a sleeping beauty? The Journal of Cell Biology. 164: 15-7. PMID 14709538 DOI: 10.1083/Jcb.200311102  0.461
2003 Tran SEF, Meinander A, Holmström TH, Rivero-Müller A, Heiskanen KM, Linnau EK, Courtney MJ, Mosser DD, Sistonen L, Eriksson JE. Heat stress downregulates FLIP and sensitizes cells to Fas receptor-mediated apoptosis Cell Death and Differentiation. 10: 1137-1147. PMID 14502237 DOI: 10.1038/Sj.Cdd.4401278  0.49
2003 Alastalo TP, Hellesuo M, Sandqvist A, Hietakangas V, Kallio M, Sistonen L. Formation of nuclear stress granules involves HSF2 and coincides with the nucleolar localization of Hsp70. Journal of Cell Science. 116: 3557-70. PMID 12865437 DOI: 10.1242/Jcs.00671  0.561
2003 Airaksinen S, Råbergh CM, Lahti A, Kaatrasalo A, Sistonen L, Nikinmaa M. Stressor-dependent regulation of the heat shock response in zebrafish, Danio rerio. Comparative Biochemistry and Physiology. Part a, Molecular & Integrative Physiology. 134: 839-46. PMID 12814792 DOI: 10.1016/S1095-6433(03)00033-3  0.494
2003 Hietakangas V, Ahlskog JK, Jakobsson AM, Hellesuo M, Sahlberg NM, Holmberg CI, Mikhailov A, Palvimo JJ, Pirkkala L, Sistonen L. Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1. Molecular and Cellular Biology. 23: 2953-68. PMID 12665592 DOI: 10.1128/Mcb.23.8.2953-2968.2003  0.538
2003 Hietakangas V, Poukkula M, Heiskanen KM, Karvinen JT, Sistonen L, Eriksson JE. Erythroid differentiation sensitizes K562 leukemia cells to TRAIL-induced apoptosis by downregulation of c-FLIP. Molecular and Cellular Biology. 23: 1278-91. PMID 12556488 DOI: 10.1128/Mcb.23.4.1278-1291.2003  0.3
2002 Holmberg CI, Tran SE, Eriksson JE, Sistonen L. Multisite phosphorylation provides sophisticated regulation of transcription factors. Trends in Biochemical Sciences. 27: 619-27. PMID 12468231 DOI: 10.1016/S0968-0004(02)02207-7  0.406
2002 Oksala NK, Kaarniranta K, Tenhunen JJ, Tiihonen R, Heino A, Sistonen L, Paimela H, Alhava E. Reperfusion but not acute ischemia in pig small intestine induces transcriptionally mediated heat shock response in situ. European Surgical Research. Europaische Chirurgische Forschung. Recherches Chirurgicales Europeennes. 34: 397-404. PMID 12403938 DOI: 10.1159/000065708  0.443
2002 Kallio M, Chang Y, Manuel M, Alastalo TP, Rallu M, Gitton Y, Pirkkala L, Loones MT, Paslaru L, Larney S, Hiard S, Morange M, Sistonen L, Mezger V. Brain abnormalities, defective meiotic chromosome synapsis and female subfertility in HSF2 null mice. The Embo Journal. 21: 2591-601. PMID 12032072 DOI: 10.1093/Emboj/21.11.2591  0.353
2002 Kaarniranta K, Oksala N, Karjalainen H, Suuronen T, Sistonen L, Helminen H, Salminen A, Lammi M. Neuronal cells show regulatory differences in the hsp70 gene response. Molecular Brain Research. 101: 136-140. PMID 12007842 DOI: 10.1016/S0169-328X(02)00179-1  0.572
2001 Nykänen P, Alastalo T, Ahlskog J, Horelli-Kuitunen N, Pirkkala L, Sistonen L. Genomic organization and promoter analysis of the human heat shock factor 2 gene. Cell Stress & Chaperones. 6: 377-385. PMID 11795475 DOI: 10.1379/1466-1268(2001)006<0377:Goapao>2.0.Co;2  0.444
2001 Hietakangas V, Elo I, Rosenström H, Coffey ET, Kyriakis JM, Eriksson JE, Sistonen L. Activation of the MKK4-JNK pathway during erythroid differentiation of K562 cells is inhibited by the heat shock factor 2-β isoform Febs Letters. 505: 168-172. PMID 11557063 DOI: 10.1016/S0014-5793(01)02810-1  0.393
2001 Holmberg CI, Hietakangas V, Mikhailov A, Rantanen JO, Kallio M, Meinander A, Hellman J, Morrice N, MacKintosh C, Morimoto RI, Eriksson JE, Sistonen L. Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1. The Embo Journal. 20: 3800-10. PMID 11447121 DOI: 10.1093/Emboj/20.14.3800  0.627
2001 Leppä S, Kajanne R, Arminen L, Sistonen L. Differential Induction of Hsp70-encoding Genes in Human Hematopoietic Cells Journal of Biological Chemistry. 276: 31713-31719. PMID 11423545 DOI: 10.1074/Jbc.M104375200  0.552
2001 Pirkkala L, Nykänen P, Sistonen L. Roles of the heat shock transcription factors in regulation of the heat shock response and beyond The Faseb Journal. 15: 1118-1131. PMID 11344080 DOI: 10.1096/Fj00-0294Rev  0.574
2001 Kaarniranta K, Holmberg C, Lammi M, Eriksson J, Sistonen L, Helminen H. Primary chondrocytes resist hydrostatic pressure-induced stress while primary synovial cells and fibroblasts show modified Hsp70 response. Osteoarthritis and Cartilage. 9: 7-13. PMID 11178942 DOI: 10.1053/Joca.2000.0354  0.348
2000 Holmberg CI, Illman SA, Kallio M, Mikhailov A, Sistonen L. Formation of nuclear HSF1 granules varies depending on stress stimuli. Cell Stress & Chaperones. 5: 219-228. PMID 11005380 DOI: 10.1379/1466-1268(2000)005<0219:Fonhgv>2.0.Co;2  0.527
2000 Jackson KM, DeLeon M, Sistonen L, Verret CR. Heat-shocked A20 lymphoma cells fail to induce degranulation of cytotoxic T lymphocytes: possible mechanism of resistance. Cellular Immunology. 203: 12-8. PMID 10915557 DOI: 10.1006/Cimm.2000.1669  0.423
2000 Kaarniranta K, Holmberg CI, Helminen HJ, Eriksson JE, Sistonen L, Lammi MJ. Protein synthesis is required for stabilization of hsp70 mRNA upon exposure to both hydrostatic pressurization and elevated temperature Febs Letters. 475: 283-286. PMID 10869572 DOI: 10.1016/S0014-5793(00)01693-8  0.51
2000 Pirkkala L, Alastalo TP, Zuo X, Benjamin IJ, Sistonen L. Disruption of Heat Shock Factor 1 Reveals an Essential Role in the Ubiquitin Proteolytic Pathway Molecular and Cellular Biology. 20: 2670-2675. PMID 10733569 DOI: 10.1128/Mcb.20.8.2670-2675.2000  0.562
2000 Eriksson M, Jokinen E, Sistonen L, Leppä S. Heat shock factor 2 is activated during mouse heart development. The International Journal of Developmental Biology. 44: 471-477. DOI: 10.1387/Ijdb.11032181  0.46
2000 Oksala NK, Kaarniranta K, Tenhunen JJ, Tiihonen R, Heino A, Sistonen L, Paimela H, Alhava E. Heat shock response during ischemia and reperfusion in pig small intestine in vivo Gastroenterology. 118. DOI: 10.1016/S0016-5085(00)85454-2  0.425
1999 Samali A, Holmberg CI, Sistonen L, Orrenius S. Thermotolerance and cell death are distinct cellular responses to stress: dependence on heat shock proteins. Febs Letters. 461: 306-310. PMID 10567716 DOI: 10.1016/S0014-5793(99)01486-6  0.492
1999 Pirkkala L, Alastalo T, Nykänen P, Seppä L, Sistonen L. Differentiation lineage-specific expression of human heat shock transcription factor 2. The Faseb Journal. 13: 1089-1098. PMID 10336892 DOI: 10.1096/Fasebj.13.9.1089  0.439
1999 Airaksinen S, Sistonen L, Nikinmaa M. Stress response in cold adapted Arctic charr Comparative Biochemistry and Physiology a-Molecular & Integrative Physiology. 124. DOI: 10.1016/S1095-6433(99)90408-7  0.371
1999 Råbergh C, Airaksinen S, Soitamo A, Björklund H, Johansson T, Nikinmaa M, Sistonen L. Cloning and characterization of tissue-specific expression of zebrafish heat shock factor 1 isoforms upon heat stress Comparative Biochemistry and Physiology a-Molecular & Integrative Physiology. 124. DOI: 10.1016/S1095-6433(99)90103-4  0.505
1998 Alastalo T, Lönnström M, Leppä S, Kaarniranta K, Pelto-Huikko M, Sistonen L, Parvinen M. Stage-specific expression and cellular localization of the heat shock factor 2 isoforms in the rat seminiferous epithelium. Experimental Cell Research. 240: 16-27. PMID 9570917 DOI: 10.1006/Excr.1997.3926  0.449
1998 Kaarniranta K, Elo M, Sironen R, Lammi M, Goldring M, Eriksson J, Sistonen L, Helminen H. Hsp70 accumulation in chondrocytic cells exposed to high continuous hydrostatic pressure coincides with mRNA stabilization rather than transcriptional activation Proceedings of the National Academy of Sciences of the United States of America. 95: 2319-2324. PMID 9482883 DOI: 10.1073/Pnas.95.5.2319  0.546
1997 Leppä S, Pirkkala L, Chow SC, Eriksson JE, Sistonen L. Thioredoxin Is Transcriptionally Induced upon Activation of Heat Shock Factor 2 Journal of Biological Chemistry. 272: 30400-30404. PMID 9374530 DOI: 10.1074/Jbc.272.48.30400  0.55
1997 Leppa S, Sistonen L. Heat Shock Response - Pathophysiological Implications Annals of Medicine. 29: 73-78. PMID 9073326 DOI: 10.3109/07853899708998745  0.592
1997 Holmberg CI, Leppä S, Eriksson JE, Sistonen L. The phorbol ester 12-O-tetradecanoylphorbol 13-acetate enhances the heat-induced stress response. Journal of Biological Chemistry. 272: 6792-6798. PMID 9045713 DOI: 10.1074/Jbc.272.10.6792  0.581
1997 Sistonen L, Morimoto RI. Characterization of in Vivo DNA-Protein Interactions in the Transcriptional Regulation of Human Heat Shock Genes Advances in Molecular and Cell Biology. 21: 111-134. DOI: 10.1016/S1569-2558(08)60284-2  0.68
1995 Laitinen J, Sistonen L, Alitalo K, Hölttä E. Cell transformation by c-Ha-rasVal12 oncogene is accompanied by a decrease in histone H1 zero and an increase in nucleosomal repeat length. Journal of Cellular Biochemistry. 57: 1-11. PMID 7721950 DOI: 10.1002/Jcb.240570102  0.3
1994 Jurivich DA, Sistonen L, Sarge KD, Morimoto RI. Arachidonate is a potent modulator of human heat shock gene transcription. Proceedings of the National Academy of Sciences of the United States of America. 91: 2280-4. PMID 8134388 DOI: 10.1073/Pnas.91.6.2280  0.633
1994 Sistonen L, Sarge KD, Morimoto RI. Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription. Molecular and Cellular Biology. 14: 2087-99. PMID 8114740 DOI: 10.1128/mcb.14.3.2087-2099.1994  0.673
1994 Mathur SK, Sistonen L, Brown IR, Murphy SP, Sarge KD, Morimoto RI. Deficient induction of human hsp70 heat shock gene transcription in Y79 retinoblastoma cells despite activation of heat shock factor 1. Proceedings of the National Academy of Sciences of the United States of America. 91: 8695-9. PMID 8078944 DOI: 10.1073/Pnas.91.18.8695  0.687
1994 Li WW, Sistonen L, Morimoto RI, Lee AS. Stress induction of the mammalian GRP78/BiP protein gene: in vivo genomic footprinting and identification of p70CORE from human nuclear extract as a DNA-binding component specific to the stress regulatory element. Molecular and Cellular Biology. 14: 5533-46. PMID 8035828 DOI: 10.1128/mcb.14.8.5533-5546.1994  0.606
1994 Morimoto RI, Jurivich DA, Kroeger PE, Mathur SK, Murphy SP, Nakai A, Sarge K, Abravaya K, Sistonen LT. 17 Regulation of Heat Shock Gene Transcription by a Family of Heat Shock Factors Cold Spring Harbor Monograph Archive. 26: 417-455. DOI: 10.1101/087969427.26.417  0.787
1992 Koskinen PJ, Sistonen L, Bravo R, Alitalo K. Immediate early gene responses of NIH 3T3 fibroblasts and NMuMG epithelial cells to TGF beta-1. Growth Factors (Chur, Switzerland). 5: 283-93. PMID 1777237 DOI: 10.3109/08977199109000292  0.301
1992 Amici C, Sistonen L, Santoro MG, Morimoto RI. Antiproliferative prostaglandins activate heat shock transcription factor. Proceedings of the National Academy of Sciences of the United States of America. 89: 6227-31. PMID 1631114 DOI: 10.1073/Pnas.89.14.6227  0.662
1992 Jurivich DA, Sistonen L, Kroes RA, Morimoto RI. Effect of sodium salicylate on the human heat shock response. Science (New York, N.Y.). 255: 1243-5. PMID 1546322 DOI: 10.1126/Science.1546322  0.668
1992 Sistonen L, Sarge KD, Phillips B, Abravaya K, Morimoto RI. Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells. Molecular and Cellular Biology. 12: 4104-11. PMID 1508207 DOI: 10.1128/mcb.12.9.4104-4111.1992  0.796
1991 Lehtola L, Sistonen L, Koskinen P, Lehväslaiho H, Di Renzo MF, Comoglio PM, Alitalo K. Constitutively activated neu oncoprotein tyrosine kinase interferes with growth factor-induced signals for gene activation. Journal of Cellular Biochemistry. 45: 69-81. PMID 1706346 DOI: 10.1002/Jcb.240450114  0.327
1991 Koskinen PJ, Sistonen L, Evan G, Morimoto R, Alitalo K. Nuclear colocalization of cellular and viral myc proteins with HSP70 in myc-overexpressing cells. Journal of Virology. 65: 842-851. DOI: 10.1128/Jvi.65.2.842-851.1991  0.599
1990 Alitalo R, Partanen J, Pertovaara L, Holtta E, Sistonen L, Andersson L, Alitalo K. Increased erythroid potentiating activity/tissue inhibitor of metalloproteinases and jun/fos transcription factor complex characterize tumor promoter-induced megakaryoblastic differentiation of K562 leukemia cells Blood. 75: 1974-1982. DOI: 10.1182/Blood.V75.10.1974.1974  0.407
1989 Lehtola L, Lehväslaiho H, Sistonen L, Beguinot L, Alitalo K. Receptor downregulation and DNA synthesis are modulated by EGF and TPA in cells expressing an EGFR/neu chimera. Growth Factors (Chur, Switzerland). 1: 323-34. PMID 2699432 DOI: 10.3109/08977198909000256  0.326
1989 Sistonen L, Hölttä E, Lehväslaiho H, Lehtola L, Alitalo K. Activation of the neu tyrosine kinase induces the fos/jun transcription factor complex, the glucose transporter and ornithine decarboxylase. The Journal of Cell Biology. 109: 1911-9. PMID 2572601 DOI: 10.1083/Jcb.109.5.1911  0.366
1989 Sistonen L, Hölttä E, Mäkelä TP, Keski-Oja J, Alitalo K. The cellular response to induction of the p21 c-Ha-ras oncoprotein includes stimulation of jun gene expression. The Embo Journal. 8: 815-822. DOI: 10.1002/J.1460-2075.1989.Tb03442.X  0.351
1989 Lehväslaiho H, Lehtola L, Sistonen L, Alitalo K. A chimeric EGF-R-neu proto-oncogene allows EGF to regulate neu tyrosine kinase and cell transformation. The Embo Journal. 8: 159-166. DOI: 10.1002/J.1460-2075.1989.Tb03360.X  0.304
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