| Year |
Citation |
Score |
| 2022 |
Holt IJ. R-Loops and Mitochondrial DNA Metabolism. Methods in Molecular Biology (Clifton, N.J.). 2528: 173-202. PMID 35704192 DOI: 10.1007/978-1-0716-2477-7_12 |
0.52 |
|
| 2022 |
Aiestaran-Zelaia I, Sánchez-Guisado MJ, Villar-Fernandez M, Azkargorta M, Fadon-Padilla L, Fernandez-Pelayo U, Perez-Rodriguez D, Ramos-Cabrer P, Spinazzola A, Elortza F, Ruíz-Cabello J, Holt IJ. 2 deoxy-D-glucose augments the mitochondrial respiratory chain in heart. Scientific Reports. 12: 6890. PMID 35478201 DOI: 10.1038/s41598-022-10168-1 |
0.362 |
|
| 2021 |
Pantic B, Ives D, Mennuni M, Perez-Rodriguez D, Fernandez-Pelayo U, Lopez de Arbina A, Muñoz-Oreja M, Villar-Fernandez M, Dang TJ, Vergani L, Johnston IG, Pitceathly RDS, McFarland R, Hanna MG, Taylor RW, ... Holt IJ, et al. 2-Deoxy-D-glucose couples mitochondrial DNA replication with mitochondrial fitness and promotes the selection of wild-type over mutant mitochondrial DNA. Nature Communications. 12: 6997. PMID 34873176 DOI: 10.1038/s41467-021-26829-0 |
0.552 |
|
| 2021 |
Horga A, Manole A, Mitchell AL, Bugiardini E, Hargreaves IP, Mowafi W, Bettencourt C, Blakely EL, He L, Polke JM, Woodward CE, Dalla Rosa I, Shah S, Pittman AM, Quinlivan R, ... ... Holt IJ, et al. Uniparental isodisomy of chromosome 2 causing MRPL44-related multisystem mitochondrial disease. Molecular Biology Reports. PMID 33742325 DOI: 10.1007/s11033-021-06188-1 |
0.485 |
|
| 2020 |
Gunning AC, Strucinska K, Muñoz Oreja M, Parrish A, Caswell R, Stals KL, Durigon R, Durlacher-Betzer K, Cunningham MH, Grochowski CM, Baptista J, Tysoe C, Baple E, Lahiri N, Homfray T, ... ... Holt IJ, et al. Recurrent De Novo NAHR Reciprocal Duplications in the ATAD3 Gene Cluster Cause a Neurogenetic Trait with Perturbed Cholesterol and Mitochondrial Metabolism. American Journal of Human Genetics. PMID 32004445 DOI: 10.1016/j.ajhg.2020.01.007 |
0.363 |
|
| 2019 |
De la Casa-Fages B, Fernández-Eulate G, Gamez J, Barahona-Hernando R, Morís G, García-Barcina M, Infante J, Zulaica M, Fernández-Pelayo U, Muñoz-Oreja M, Urtasun M, Olaskoaga A, Zelaya V, Jericó I, Saez-Villaverde R, ... ... Holt I, et al. Reply to: "Mitochondrial Parkinsonism due to SPG7/Paraplegin variants with secondary mtDNA depletion". Movement Disorders : Official Journal of the Movement Disorder Society. 34: 1932-1933. PMID 31845766 DOI: 10.1002/mds.27899 |
0.515 |
|
| 2019 |
De la Casa-Fages B, Fernández-Eulate G, Gamez J, Barahona-Hernando R, Morís G, García-Barcina M, Infante J, Zulaica M, Fernández-Pelayo U, Muñoz-Oreja M, Urtasun M, Olaskoaga A, Zelaya V, Jericó I, Saez-Villaverde R, ... ... Holt I, et al. Parkinsonism and spastic paraplegia type 7: Expanding the spectrum of mitochondrial Parkinsonism. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 31433872 DOI: 10.1002/mds.27812 |
0.551 |
|
| 2019 |
Holt IJ. The Jekyll and Hyde character of RNase H1 and its multiple roles in mitochondrial DNA metabolism. Dna Repair. PMID 31178343 DOI: 10.1016/j.dnarep.2019.06.001 |
0.654 |
|
| 2019 |
Holt IJ. The mitochondrial R-loop. Nucleic Acids Research. PMID 31045202 DOI: 10.1093/nar/gkz277 |
0.657 |
|
| 2019 |
Bugiardini E, Mitchell AL, Rosa ID, Horning-Do HT, Pitmann A, Poole OV, Holton JL, Shah S, Woodward C, Hargreaves I, Quinlivan R, Amunts A, Wiesner RJ, Houlden H, Holt IJ, et al. MRPS25 mutations impair mitochondrial translation and cause encephalomyopathy. Human Molecular Genetics. PMID 31039582 DOI: 10.1093/Hmg/Ddz093 |
0.507 |
|
| 2018 |
Cluett TJ, Akman G, Reyes A, Kazak L, Mitchell A, Wood SR, Spinazzola A, Spelbrink JN, Holt IJ. Transcript availability dictates the balance between strand-asynchronous and strand-coupled mitochondrial DNA replication. Nucleic Acids Research. PMID 30239839 DOI: 10.1093/Nar/Gky852 |
0.776 |
|
| 2018 |
Durigon R, Mitchell AL, Jones AW, Manole A, Mennuni M, Hirst EM, Houlden H, Maragni G, Lattante S, Doronzio PN, Dalla Rosa I, Zollino M, Holt IJ, Spinazzola A. LETM1 couples mitochondrial DNA metabolism and nutrient preference. Embo Molecular Medicine. PMID 30012579 DOI: 10.15252/emmm.201708550 |
0.603 |
|
| 2017 |
Moss CF, Dalla Rosa I, Hunt LE, Yasukawa T, Young R, Jones AWE, Reddy K, Desai R, Virtue S, Elgar G, Voshol P, Taylor MS, Holt IJ, Reijns MAM, Spinazzola A. Aberrant ribonucleotide incorporation and multiple deletions in mitochondrial DNA of the murine MPV17 disease model. Nucleic Acids Research. PMID 29106596 DOI: 10.1093/Nar/Gkx1009 |
0.557 |
|
| 2017 |
Desai R, Frazier AE, Durigon R, Patel H, Jones AW, Dalla Rosa I, Lake NJ, Compton AG, Mountford HS, Tucker EJ, Mitchell ALR, Jackson D, Sesay A, Di Re M, van den Heuvel LP, ... ... Holt IJ, et al. ATAD3 gene cluster deletions cause cerebellar dysfunction associated with altered mitochondrial DNA and cholesterol metabolism. Brain : a Journal of Neurology. 140: 1595-1610. PMID 28549128 DOI: 10.1093/brain/awx094 |
0.534 |
|
| 2017 |
Bugiardini E, Poole OV, Manole A, Pittman AM, Horga A, Hargreaves I, Woodward CE, Sweeney MG, Holton JL, Taanman JW, Plant GT, Poulton J, Zeviani M, Ghezzi D, Taylor J, ... ... Holt IJ, et al. Clinicopathologic and molecular spectrum of RNASEH1-related mitochondrial disease. Neurology. Genetics. 3: e149. PMID 28508084 DOI: 10.1212/NXG.0000000000000149 |
0.497 |
|
| 2016 |
Liyanage SU, Coyaud E, Laurent EM, Hurren R, Maclean N, Wood SR, Kazak L, Shamas-Din A, Holt I, Raught B, Schimmer A. Characterizing the mitochondrial DNA polymerase gamma interactome by BioID identifies Ruvbl2 localizes to the mitochondria. Mitochondrion. PMID 27845271 DOI: 10.1016/J.Mito.2016.11.001 |
0.775 |
|
| 2016 |
Malena A, Pantic B, Borgia D, Sgarbi G, Solaini G, Holt IJ, Spinazzola A, Perissinotto E, Sandri M, Baracca A, Vergani L. Mitochondrial quality control: Cell-type-dependent responses to pathological mutant mitochondrial DNA. Autophagy. 0. PMID 27627835 DOI: 10.1080/15548627.2016.1226734 |
0.575 |
|
| 2016 |
Akman G, Desai R, Bailey LJ, Yasukawa T, Dalla Rosa I, Durigon R, Holmes JB, Moss CF, Mennuni M, Houlden H, Crouch RJ, Hanna MG, Pitceathly RD, Spinazzola A, Holt IJ. Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria. Proceedings of the National Academy of Sciences of the United States of America. PMID 27402764 DOI: 10.1073/pnas.1600537113 |
0.41 |
|
| 2016 |
Dalla Rosa I, Cámara Y, Durigon R, Moss CF, Vidoni S, Akman G, Hunt L, Johnson MA, Grocott S, Wang L, Thorburn DR, Hirano M, Poulton J, Taylor RW, Elgar G, ... ... Holt IJ, et al. MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in Mitochondria. Plos Genetics. 12: e1005779. PMID 26760297 DOI: 10.1371/Journal.Pgen.1005779 |
0.686 |
|
| 2016 |
Holt IJ, Kazak L, Reyes A, Wood SR. Analysis of Replicating Mitochondrial DNA by In Organello Labeling and Two-Dimensional Agarose Gel Electrophoresis. Methods in Molecular Biology (Clifton, N.J.). 1351: 95-113. PMID 26530677 DOI: 10.1007/978-1-4939-3040-1_8 |
0.754 |
|
| 2015 |
Gerhold JM, Cansiz-Arda Ş, Lõhmus M, Engberg O, Reyes A, van Rennes H, Sanz A, Holt IJ, Cooper HM, Spelbrink JN. Corrigendum: Human Mitochondrial DNA-Protein Complexes Attach to a Cholesterol-Rich Membrane Structure. Scientific Reports. 5: 17119. PMID 26656719 DOI: 10.1038/srep17119 |
0.501 |
|
| 2015 |
Gerhold JM, Cansiz-Arda Ş, Lõhmus M, Engberg O, Reyes A, van Rennes H, Sanz A, Holt IJ, Cooper HM, Spelbrink JN. Human Mitochondrial DNA-Protein Complexes Attach to a Cholesterol-Rich Membrane Structure. Scientific Reports. 5: 15292. PMID 26478270 DOI: 10.1038/srep15292 |
0.501 |
|
| 2015 |
Holmes JB, Akman G, Wood SR, Sakhuja K, Cerritelli SM, Moss C, Bowmaker MR, Jacobs HT, Crouch RJ, Holt IJ. Primer retention owing to the absence of RNase H1 is catastrophic for mitochondrial DNA replication. Proceedings of the National Academy of Sciences of the United States of America. PMID 26162680 DOI: 10.1073/pnas.1503653112 |
0.632 |
|
| 2015 |
Litwin TR, Solà M, Holt IJ, Neuman KC. A robust assay to measure DNA topology-dependent protein binding affinity. Nucleic Acids Research. 43: e43. PMID 25552413 DOI: 10.1093/Nar/Gku1381 |
0.434 |
|
| 2014 |
Holt IJ, Jacobs HT. Unique features of DNA replication in mitochondria: a functional and evolutionary perspective. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 36: 1024-31. PMID 25220172 DOI: 10.1002/bies.201400052 |
0.511 |
|
| 2014 |
Dalla Rosa I, Durigon R, Pearce SF, Rorbach J, Hirst EM, Vidoni S, Reyes A, Brea-Calvo G, Minczuk M, Woellhaf MW, Herrmann JM, Huynen MA, Holt IJ, Spinazzola A. MPV17L2 is required for ribosome assembly in mitochondria. Nucleic Acids Research. 42: 8500-15. PMID 24948607 DOI: 10.1093/Nar/Gku513 |
0.664 |
|
| 2014 |
Holt IJ, Speijer D, Kirkwood TB. The road to rack and ruin: selecting deleterious mitochondrial DNA variants. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 369: 20130451. PMID 24864317 DOI: 10.1098/rstb.2013.0451 |
0.634 |
|
| 2013 |
García-Gómez S, Reyes A, Martínez-Jiménez MI, Chocrón ES, Mourón S, Terrados G, Powell C, Salido E, Méndez J, Holt IJ, Blanco L. PrimPol, an archaic primase/polymerase operating in human cells. Molecular Cell. 52: 541-53. PMID 24207056 DOI: 10.1016/J.Molcel.2013.09.025 |
0.647 |
|
| 2013 |
Jõers P, Lewis SC, Fukuoh A, Parhiala M, Ellilä S, Holt IJ, Jacobs HT. Mitochondrial transcription terminator family members mTTF and mTerf5 have opposing roles in coordination of mtDNA synthesis. Plos Genetics. 9: e1003800. PMID 24068965 DOI: 10.1371/journal.pgen.1003800 |
0.418 |
|
| 2013 |
Kazak L, Reyes A, He J, Wood SR, Brea-Calvo G, Holen TT, Holt IJ. A cryptic targeting signal creates a mitochondrial FEN1 isoform with tailed R-Loop binding properties. Plos One. 8: e62340. PMID 23675412 DOI: 10.1371/Journal.Pone.0062340 |
0.775 |
|
| 2013 |
Reyes A, Kazak L, Wood SR, Yasukawa T, Jacobs HT, Holt IJ. Mitochondrial DNA replication proceeds via a 'bootlace' mechanism involving the incorporation of processed transcripts. Nucleic Acids Research. 41: 5837-50. PMID 23595151 DOI: 10.1093/Nar/Gkt196 |
0.757 |
|
| 2013 |
Kazak L, Reyes A, Duncan AL, Rorbach J, Wood SR, Brea-Calvo G, Gammage PA, Robinson AJ, Minczuk M, Holt IJ. Alternative translation initiation augments the human mitochondrial proteome. Nucleic Acids Research. 41: 2354-69. PMID 23275553 DOI: 10.1093/Nar/Gks1347 |
0.759 |
|
| 2012 |
Holt IJ, Reyes A. Human mitochondrial DNA replication. Cold Spring Harbor Perspectives in Biology. 4. PMID 23143808 DOI: 10.1101/cshperspect.a012971 |
0.676 |
|
| 2012 |
Kazak L, Reyes A, Holt IJ. Minimizing the damage: repair pathways keep mitochondrial DNA intact. Nature Reviews. Molecular Cell Biology. 13: 659-71. PMID 22992591 DOI: 10.1038/Nrm3439 |
0.738 |
|
| 2012 |
Reijns MA, Rabe B, Rigby RE, Mill P, Astell KR, Lettice LA, Boyle S, Leitch A, Keighren M, Kilanowski F, Devenney PS, Sexton D, Grimes G, Holt IJ, Hill RE, et al. Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development. Cell. 149: 1008-22. PMID 22579044 DOI: 10.1016/j.cell.2012.04.011 |
0.336 |
|
| 2012 |
He J, Cooper HM, Reyes A, Di Re M, Sembongi H, Litwin TR, Gao J, Neuman KC, Fearnley IM, Spinazzola A, Walker JE, Holt IJ. Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis. Nucleic Acids Research. 40: 6109-21. PMID 22453275 DOI: 10.1093/Nar/Gks266 |
0.631 |
|
| 2012 |
He J, Cooper HM, Reyes A, Di Re M, Kazak L, Wood SR, Mao CC, Fearnley IM, Walker JE, Holt IJ. Human C4orf14 interacts with the mitochondrial nucleoid and is involved in the biogenesis of the small mitochondrial ribosomal subunit. Nucleic Acids Research. 40: 6097-108. PMID 22447445 DOI: 10.1093/Nar/Gks257 |
0.757 |
|
| 2012 |
Sharma NK, Reyes A, Green P, Caron MJ, Bonini MG, Gordon DM, Holt IJ, Santos JH. Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria. Nucleic Acids Research. 40: 712-25. PMID 21937513 DOI: 10.1093/Nar/Gkr758 |
0.58 |
|
| 2011 |
Reyes A, He J, Mao CC, Bailey LJ, Di Re M, Sembongi H, Kazak L, Dzionek K, Holmes JB, Cluett TJ, Harbour ME, Fearnley IM, Crouch RJ, Conti MA, Adelstein RS, ... ... Holt IJ, et al. Actin and myosin contribute to mammalian mitochondrial DNA maintenance. Nucleic Acids Research. 39: 5098-108. PMID 21398640 DOI: 10.1093/Nar/Gkr052 |
0.756 |
|
| 2011 |
Minczuk M, He J, Duch AM, Ettema TJ, Chlebowski A, Dzionek K, Nijtmans LG, Huynen MA, Holt IJ. TEFM (c17orf42) is necessary for transcription of human mtDNA. Nucleic Acids Research. 39: 4284-99. PMID 21278163 DOI: 10.1093/Nar/Gkq1224 |
0.543 |
|
| 2011 |
Hyvärinen AK, Pohjoismäki JL, Holt IJ, Jacobs HT. Overexpression of MTERFD1 or MTERFD3 impairs the completion of mitochondrial DNA replication. Molecular Biology Reports. 38: 1321-8. PMID 20577816 DOI: 10.1007/s11033-010-0233-9 |
0.681 |
|
| 2010 |
Suzuki Y, Holmes JB, Cerritelli SM, Sakhuja K, Minczuk M, Holt IJ, Crouch RJ. An upstream open reading frame and the context of the two AUG codons affect the abundance of mitochondrial and nuclear RNase H1. Molecular and Cellular Biology. 30: 5123-34. PMID 20823270 DOI: 10.1128/Mcb.00619-10 |
0.42 |
|
| 2010 |
Poulton J, Chiaratti MR, Meirelles FV, Kennedy S, Wells D, Holt IJ. Transmission of mitochondrial DNA diseases and ways to prevent them. Plos Genetics. 6. PMID 20711358 DOI: 10.1371/journal.pgen.1001066 |
0.594 |
|
| 2010 |
Pohjoismäki JL, Holmes JB, Wood SR, Yang MY, Yasukawa T, Reyes A, Bailey LJ, Cluett TJ, Goffart S, Willcox S, Rigby RE, Jackson AP, Spelbrink JN, Griffith JD, Crouch RJ, ... ... Holt IJ, et al. Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid. Journal of Molecular Biology. 397: 1144-55. PMID 20184890 DOI: 10.1016/J.Jmb.2010.02.029 |
0.602 |
|
| 2010 |
Fusté JM, Wanrooij S, Jemt E, Granycome CE, Cluett TJ, Shi Y, Atanassova N, Holt IJ, Gustafsson CM, Falkenberg M. Mitochondrial RNA polymerase is needed for activation of the origin of light-strand DNA replication. Molecular Cell. 37: 67-78. PMID 20129056 DOI: 10.1016/J.Molcel.2009.12.021 |
0.623 |
|
| 2010 |
Holt IJ. Zen and the art of mitochondrial DNA maintenance. Trends in Genetics : Tig. 26: 103-9. PMID 20117854 DOI: 10.1016/j.tig.2009.12.011 |
0.692 |
|
| 2010 |
Holmes JB, Pohjoismäki JL, Yang M, Yasukawa T, Cluett TJ, Reyes A, Goffart S, Willcox S, Rigby RE, Jackson AP, Spelbrink JN, Griffith JD, Crouch RJ, Jacobs HT, Holt IJ. 89 Analysis of extensive RNA/DNA hybrids in the replicating mammalian mitochondrial genome Mitochondrion. 10: 225. DOI: 10.1016/J.Mito.2009.12.082 |
0.613 |
|
| 2009 |
Mao CC, Holt IJ. Clinical and molecular aspects of diseases of mitochondrial DNA instability. Chang Gung Medical Journal. 32: 354-69. PMID 19664342 |
0.569 |
|
| 2009 |
Di Re M, Sembongi H, He J, Reyes A, Yasukawa T, Martinsson P, Bailey LJ, Goffart S, Boyd-kirkup JD, Wong TS, Fersht AR, Spelbrink JN, Holt IJ. The accessory subunit of mitochondrial DNA polymerase γ determines the DNA content of mitochondrial nucleoids in human cultured cells Nucleic Acids Research. 37: 5701-5713. PMID 19625489 DOI: 10.1093/Nar/Gkp614 |
0.752 |
|
| 2009 |
Malena A, Loro E, Di Re M, Holt IJ, Vergani L. Inhibition of mitochondrial fission favours mutant over wild-type mitochondrial DNA. Human Molecular Genetics. 18: 3407-16. PMID 19561330 DOI: 10.1093/hmg/ddp281 |
0.622 |
|
| 2009 |
Holt IJ. Mitochondrial DNA replication and repair: all a flap. Trends in Biochemical Sciences. 34: 358-65. PMID 19559620 DOI: 10.1016/j.tibs.2009.03.007 |
0.655 |
|
| 2009 |
Pohjoismäki JL, Goffart S, Tyynismaa H, Willcox S, Ide T, Kang D, Suomalainen A, Karhunen PJ, Griffith JD, Holt IJ, Jacobs HT. Human heart mitochondrial DNA is organized in complex catenated networks containing abundant four-way junctions and replication forks. The Journal of Biological Chemistry. 284: 21446-57. PMID 19525233 DOI: 10.1074/Jbc.M109.016600 |
0.49 |
|
| 2009 |
Reyes A, Yasukawa T, Cluett TJ, Holt IJ. Analysis of mitochondrial DNA by two-dimensional agarose gel electrophoresis. Methods in Molecular Biology (Clifton, N.J.). 554: 15-35. PMID 19513665 DOI: 10.1007/978-1-59745-521-3_2 |
0.647 |
|
| 2009 |
Poulton J, Holt IJ. 163rd ENMC International Workshop: nucleoid and nucleotide biology in syndromes of mitochondrial DNA depletion myopathy 12-14 December 2008, Naarden, The Netherlands. Neuromuscular Disorders : Nmd. 19: 439-43. PMID 19464176 DOI: 10.1016/j.nmd.2009.04.009 |
0.622 |
|
| 2009 |
Bailey LJ, Cluett TJ, Reyes A, Prolla TA, Poulton J, Leeuwenburgh C, Holt IJ. Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA. Nucleic Acids Research. 37: 2327-35. PMID 19244310 DOI: 10.1093/Nar/Gkp091 |
0.539 |
|
| 2009 |
Iacovino M, Granycome C, Sembongi H, Bokori-Brown M, Butow RA, Holt IJ, Bateman JM. The conserved translocase Tim17 prevents mitochondrial DNA loss. Human Molecular Genetics. 18: 65-74. PMID 18826960 DOI: 10.1093/hmg/ddn313 |
0.64 |
|
| 2007 |
Reyes A, Yasukawa T, Holt IJ. Analysis of replicating mitochondrial DNA by two-dimensional agarose gel electrophoresis. Methods in Molecular Biology (Clifton, N.J.). 372: 219-32. PMID 18314729 DOI: 10.1007/978-1-59745-365-3_16 |
0.665 |
|
| 2007 |
Hyvärinen AK, Pohjoismäki JL, Reyes A, Wanrooij S, Yasukawa T, Karhunen PJ, Spelbrink JN, Holt IJ, Jacobs HT. The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA. Nucleic Acids Research. 35: 6458-74. PMID 17884915 DOI: 10.1093/nar/gkm676 |
0.658 |
|
| 2007 |
Holt IJ, He J, Mao CC, Boyd-Kirkup JD, Martinsson P, Sembongi H, Reyes A, Spelbrink JN. Mammalian mitochondrial nucleoids: organizing an independently minded genome. Mitochondrion. 7: 311-21. PMID 17698423 DOI: 10.1016/j.mito.2007.06.004 |
0.425 |
|
| 2007 |
Sembongi H, Di Re M, Bokori-Brown M, Holt IJ. The yeast Holliday junction resolvase, CCE1, can restore wild-type mitochondrial DNA to human cells carrying rearranged mitochondrial DNA. Human Molecular Genetics. 16: 2306-14. PMID 17666405 DOI: 10.1093/hmg/ddm182 |
0.681 |
|
| 2007 |
Vergani L, Malena A, Sabatelli P, Loro E, Cavallini L, Magalhaes P, Valente L, Bragantini F, Carrara F, Leger B, Poulton J, Russell AP, Holt IJ. Cultured muscle cells display defects of mitochondrial myopathy ameliorated by anti-oxidants. Brain : a Journal of Neurology. 130: 2715-24. PMID 17626036 DOI: 10.1093/brain/awm151 |
0.485 |
|
| 2007 |
He J, Mao CC, Reyes A, Sembongi H, Di Re M, Granycome C, Clippingdale AB, Fearnley IM, Harbour M, Robinson AJ, Reichelt S, Spelbrink JN, Walker JE, Holt IJ. The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization. The Journal of Cell Biology. 176: 141-6. PMID 17210950 DOI: 10.1083/Jcb.200609158 |
0.649 |
|
| 2006 |
Bokori-Brown M, Holt IJ. Expression of algal nuclear ATP synthase subunit 6 in human cells results in protein targeting to mitochondria but no assembly into ATP synthase. Rejuvenation Research. 9: 455-69. PMID 17105386 DOI: 10.1089/rej.2006.9.455 |
0.385 |
|
| 2006 |
Yasukawa T, Reyes A, Cluett TJ, Yang MY, Bowmaker M, Jacobs HT, Holt IJ. Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand. The Embo Journal. 25: 5358-71. PMID 17066082 DOI: 10.1038/sj.emboj.7601392 |
0.698 |
|
| 2006 |
Pohjoismäki JL, Wanrooij S, Hyvärinen AK, Goffart S, Holt IJ, Spelbrink JN, Jacobs HT. Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells. Nucleic Acids Research. 34: 5815-28. PMID 17062618 DOI: 10.1093/nar/gkl703 |
0.597 |
|
| 2006 |
Kirino Y, Yasukawa T, Marjavaara SK, Jacobs HT, Holt IJ, Watanabe K, Suzuki T. Acquisition of the wobble modification in mitochondrial tRNALeu(CUN) bearing the G12300A mutation suppresses the MELAS molecular defect. Human Molecular Genetics. 15: 897-904. PMID 16446307 DOI: 10.1093/Hmg/Ddl007 |
0.337 |
|
| 2005 |
Yasukawa T, Yang MY, Jacobs HT, Holt IJ. A bidirectional origin of replication maps to the major noncoding region of human mitochondrial DNA. Molecular Cell. 18: 651-62. PMID 15949440 DOI: 10.1016/j.molcel.2005.05.002 |
0.58 |
|
| 2005 |
Turner CJ, Granycome C, Hurst R, Pohler E, Juhola MK, Juhola MI, Jacobs HT, Sutherland L, Holt IJ. Systematic segregation to mutant mitochondrial DNA and accompanying loss of mitochondrial DNA in human NT2 teratocarcinoma Cybrids. Genetics. 170: 1879-85. PMID 15944344 DOI: 10.1534/genetics.105.043653 |
0.686 |
|
| 2005 |
Yasukawa T, Kirino Y, Ishii N, Holt IJ, Jacobs HT, Makifuchi T, Fukuhara N, Ohta S, Suzuki T, Watanabe K. Wobble modification deficiency in mutant tRNAs in patients with mitochondrial diseases. Febs Letters. 579: 2948-52. PMID 15893315 DOI: 10.1016/J.Febslet.2005.04.038 |
0.391 |
|
| 2005 |
Reyes A, Yang MY, Bowmaker M, Holt IJ. Bidirectional replication initiates at sites throughout the mitochondrial genome of birds. The Journal of Biological Chemistry. 280: 3242-50. PMID 15557283 DOI: 10.1074/jbc.M411916200 |
0.44 |
|
| 2004 |
Tyynismaa H, Sembongi H, Bokori-Brown M, Granycome C, Ashley N, Poulton J, Jalanko A, Spelbrink JN, Holt IJ, Suomalainen A. Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number. Human Molecular Genetics. 13: 3219-27. PMID 15509589 DOI: 10.1093/hmg/ddh342 |
0.474 |
|
| 2003 |
Bowmaker M, Yang MY, Yasukawa T, Reyes A, Jacobs HT, Huberman JA, Holt IJ. Mammalian mitochondrial DNA replicates bidirectionally from an initiation zone. The Journal of Biological Chemistry. 278: 50961-9. PMID 14506235 DOI: 10.1074/jbc.M308028200 |
0.765 |
|
| 2003 |
Holt IJ, Jacobs HT. Response: The mitochondrial DNA replication bubble has not burst. Trends in Biochemical Sciences. 28: 355-6. PMID 12878001 DOI: 10.1016/S0968-0004(03)00133-6 |
0.648 |
|
| 2002 |
Yang MY, Bowmaker M, Reyes A, Vergani L, Angeli P, Gringeri E, Jacobs HT, Holt IJ. Biased incorporation of ribonucleotides on the mitochondrial L-strand accounts for apparent strand-asymmetric DNA replication. Cell. 111: 495-505. PMID 12437923 |
0.614 |
|
| 2002 |
Nijtmans LG, Henderson NS, Holt IJ. Blue Native electrophoresis to study mitochondrial and other protein complexes. Methods (San Diego, Calif.). 26: 327-34. PMID 12054923 DOI: 10.1016/S1046-2023(02)00038-5 |
0.458 |
|
| 2001 |
Kajander OA, Karhunen PJ, Holt IJ, Jacobs HT. Prominent mitochondrial DNA recombination intermediates in human heart muscle. Embo Reports. 2: 1007-12. PMID 11713192 DOI: 10.1093/embo-reports/kve233 |
0.529 |
|
| 2001 |
Vergani L, Prescott AR, Holt IJ. Corrigendum to "Rhabdomyosarcoma rho(0) cells: isolation and characterization of mitochondrial DNA depleted cell line with 'muscle-like' properties" Neuromuscular Disorders : Nmd. 11: 99. PMID 11342121 DOI: 10.1016/S0960-8966(00)00194-2 |
0.476 |
|
| 2001 |
Nijtmans LG, Henderson NS, Attardi G, Holt IJ. Impaired ATP synthase assembly associated with a mutation in the human ATP synthase subunit 6 gene. The Journal of Biological Chemistry. 276: 6755-62. PMID 11076946 DOI: 10.1074/Jbc.M008114200 |
0.693 |
|
| 2000 |
Kajander OA, Rovio AT, Majamaa K, Poulton J, Spelbrink JN, Holt IJ, Karhunen PJ, Jacobs HT. Human mtDNA sublimons resemble rearranged mitochondrial genoms found in pathological states. Human Molecular Genetics. 9: 2821-35. PMID 11092758 |
0.44 |
|
| 2000 |
Vergani L, Prescott AR, Holt IJ. Rhabdomyosarcoma rho(0) cells: isolation and characterization of a mitochondrial DNA depleted cell line with 'muscle-like' properties. Neuromuscular Disorders : Nmd. 10: 454-9. PMID 10899454 DOI: 10.1016/S0960-8966(00)00096-1 |
0.52 |
|
| 2000 |
Holt IJ, Lorimer HE, Jacobs HT. Coupled leading- and lagging-strand synthesis of mammalian mitochondrial DNA. Cell. 100: 515-24. PMID 10721989 |
0.634 |
|
| 2000 |
Vergani L, Rossi R, Brierley CH, Hanna M, Holt IJ. Introduction of heteroplasmic mitochondrial DNA (mtDNA) from a patient with NARP into two human rho degrees cell lines is associated either with selection and maintenance of NARP mutant mtDNA or failure to maintain mtDNA. Human Molecular Genetics. 8: 1751-5. PMID 10441339 DOI: 10.1093/HMG/8.9.1751 |
0.489 |
|
| 1998 |
El Meziane A, Lehtinen SK, Hance N, Nijtmans LG, Dunbar D, Holt IJ, Jacobs HT. A tRNA suppressor mutation in human mitochondria. Nature Genetics. 18: 350-3. PMID 9537417 DOI: 10.1038/NG0498-350 |
0.348 |
|
| 1997 |
Holt IJ, Dunbar DR, Jacobs HT. Behaviour of a population of partially duplicated mitochondrial DNA molecules in cell culture: segregation, maintenance and recombination dependent upon nuclear background. Human Molecular Genetics. 6: 1251-60. PMID 9259270 DOI: 10.1093/HMG/6.8.1251 |
0.607 |
|
| 1997 |
Reid FM, Rovio A, Holt IJ, Jacobs HT. Molecular phenotype of a human lymphoblastoid cell-line homoplasmic for the np 7445 deafness-associated mitochondrial mutation. Human Molecular Genetics. 6: 443-9. PMID 9147648 DOI: 10.1093/HMG/6.3.443 |
0.46 |
|
| 1996 |
Marchington DR, Poulton J, Sellar A, Holt IJ. Do sequence variants in the major non-coding region of the mitochondrial genome influence mitochondrial mutations associated with disease? Human Molecular Genetics. 5: 473-9. PMID 8845839 DOI: 10.1093/HMG/5.4.473 |
0.356 |
|
| 1996 |
Dunbar DR, Moonie PA, Zeviani M, Holt IJ. Complex I deficiency is associated with 3243G:C mitochondrial DNA in osteosarcoma cell cybrids Human Molecular Genetics. 5: 123-129. PMID 8789449 DOI: 10.1093/hmg/5.1.123 |
0.578 |
|
| 1995 |
Poulton J, Holt IJ. Mitochondrial DNA: does more lead to less? Nature Genetics. 8: 313-5. PMID 7894476 DOI: 10.1038/NG1294-313 |
0.693 |
|
| 1995 |
Dunbar DR, Moonie PA, Jacobs HT, Holt IJ. Different cellular backgrounds confer a marked advantage to either mutant or wild-type mitochondrial genomes. Proceedings of the National Academy of Sciences of the United States of America. 92: 6562-6. PMID 7604033 DOI: 10.1073/PNAS.92.14.6562 |
0.435 |
|
| 1994 |
Dunbar DR, Moonie PA, Swingler RJ, Davidson D, Roberts R, Holt IJ. Maternally transmitted partial direct tandem duplication of mitochondrial DNA associated with diabetes mellitus. Human Molecular Genetics. 2: 1619-24. PMID 8268914 DOI: 10.1093/HMG/2.10.1619 |
0.659 |
|
| 1992 |
Hammans SR, Sweeney MG, Holt IJ, Cooper JM, Toscano A, Clark JB, Morgan-Hughes JA, Harding AE. Evidence for intramitochondrial complementation between deleted and normal mitochondrial DNA in some patients with mitochondrial myopathy. Journal of the Neurological Sciences. 107: 87-92. PMID 1315844 DOI: 10.1016/0022-510X(92)90213-5 |
0.661 |
|
| 1991 |
Morgan-Hughes JA, Cooper JM, Holt IJ, Harding AE, Schapira AH, Clark JB. Mitochondrial myopathies: clinical defects. Biochemical Society Transactions. 18: 523-6. PMID 2276423 DOI: 10.1042/BST0180523 |
0.44 |
|
| 1991 |
Harding AE, Holt IJ, Cooper JM, Schapira AH, Sweeney M, Clark JB, Morgan-Hughes JA. Mitochondrial myopathies: genetic defects. Biochemical Society Transactions. 18: 519-22. PMID 2276422 DOI: 10.1042/BST0180519 |
0.425 |
|
| 1991 |
Cooper JM, Schapira AH, Holt IJ, Toscano A, Harding AE, Morgan-Hughes JA, Clark JB. Biochemical and molecular aspects of human mitochondrial respiratory chain disorders. Biochemical Society Transactions. 18: 517-9. PMID 2177405 DOI: 10.1042/BST0180517 |
0.399 |
|
| 1991 |
Schapira AH, Holt IJ, Sweeney M, Harding AE, Jenner P, Marsden CD. Mitochondrial DNA analysis in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 5: 294-7. PMID 1979656 DOI: 10.1002/Mds.870050406 |
0.449 |
|
| 1990 |
Harding AE, Holt IJ. Mitochondrial myopathies. British Medical Bulletin. 45: 760-71. PMID 2688827 DOI: 10.1093/oxfordjournals.bmb.a072356 |
0.456 |
|
| 1990 |
Holt IJ, Harding AE, Cooper JM, Schapira AH, Toscano A, Clark JB, Morgan-Hughes JA. Mitochondrial myopathies: clinical and biochemical features of 30 patients with major deletions of muscle mitochondrial DNA. Annals of Neurology. 26: 699-708. PMID 2604380 DOI: 10.1002/ANA.410260603 |
0.429 |
|
| 1990 |
Holt IJ, Miller DH, Harding AE. Genetic heterogeneity and mitochondrial DNA heteroplasmy in Leber's hereditary optic neuropathy. Journal of Medical Genetics. 26: 739-43. PMID 2575667 DOI: 10.1136/jmg.26.12.739 |
0.442 |
|
| 1990 |
Morgan-Hughes JA, Schapira AH, Cooper JM, Holt IJ, Harding AE, Clark JB. The molecular pathology of respiratory-chain dysfunction in human mitochondrial myopathies. Biochimica Et Biophysica Acta. 1018: 217-22. PMID 2168209 DOI: 10.1016/0005-2728(90)90252-Y |
0.519 |
|
| 1989 |
Holt IJ, Miller DH, Harding AE. Restriction endonuclease analysis of leukocyte mitochondrial DNA in Leber's optic atrophy. Journal of Neurology, Neurosurgery, and Psychiatry. 51: 1075-7. PMID 2905730 DOI: 10.1136/jnnp.51.8.1075 |
0.487 |
|
| 1989 |
Holt IJ, Harding AE, Morgan-Hughes JA. Deletions of muscle mitochondrial DNA in mitochondrial myopathies: sequence analysis and possible mechanisms. Nucleic Acids Research. 17: 4465-9. PMID 2748329 DOI: 10.1093/NAR/17.12.4465 |
0.573 |
|
| 1988 |
Holt IJ, Cooper JM, Morgan-Hughes JA, Harding AE. Deletions of muscle mitochondrial DNA. Lancet (London, England). 1: 1462. PMID 2898614 DOI: 10.1016/S0140-6736(88)92273-8 |
0.583 |
|
| 1988 |
Holt IJ, Harding AE, Morgan-Hughes JA. Mitochondrial DNA polymorphism in mitochondrial myopathy. Human Genetics. 79: 53-7. PMID 2896621 DOI: 10.1007/BF00291710 |
0.643 |
|
| 1988 |
Holt IJ, Harding AE, Morgan-Hughes JA. Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies. Nature. 331: 717-9. PMID 2830540 DOI: 10.1038/331717A0 |
0.58 |
|
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