☰

Joanna Rorbach - Publications

Affiliations: 
2009-2016 MRC Mitochondrial Biology Unit University of Cambridge, Cambridge, England, United Kingdom 
Tree Info Similar researchers PubMed Report error

55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Zhang J, Koolmeister C, Han J, Filograna R, Hanke L, Àdori M, Sheward DJ, Teifel S, Gopalakrishna S, Shao Q, Liu Y, Zhu K, Harris RA, McInerney G, Murrell B, ... ... Rorbach J, et al. Antigen receptor stimulation induces purifying selection against pathogenic mitochondrial tRNA mutations. Jci Insight. 8. PMID 37681412 DOI: 10.1172/jci.insight.167656  0.41
2023 Khawaja A, Cipullo M, Krüger A, Rorbach J. Insights into mitoribosomal biogenesis from recent structural studies. Trends in Biochemical Sciences. PMID 37169615 DOI: 10.1016/j.tibs.2023.04.002  0.504
2023 Remes C, Nguyen MD, Spahr H, Ng M, Fritsch C, Bhattacharya A, Li H, Cooperman B, Rorbach J. Assembly of the Mitochondrial Translation Initiation Complex. Methods in Molecular Biology (Clifton, N.J.). 2661: 217-232. PMID 37166640 DOI: 10.1007/978-1-0716-3171-3_13  0.625
2023 Remes C, Khawaja A, Pearce SF, Dinan AM, Gopalakrishna S, Cipullo M, Kyriakidis V, Zhang J, Dopico XC, Yukhnovets O, Atanassov I, Firth AE, Cooperman B, Rorbach J. Translation initiation of leaderless and polycistronic transcripts in mammalian mitochondria. Nucleic Acids Research. 51: 891-907. PMID 36629253 DOI: 10.1093/nar/gkac1233  0.645
2023 Krüger A, Remes C, Shiriaev DI, Liu Y, Spåhr H, Wibom R, Atanassov I, Nguyen MD, Cooperman BS, Rorbach J. Human mitochondria require mtRF1 for translation termination at non-canonical stop codons. Nature Communications. 14: 30. PMID 36596788 DOI: 10.1038/s41467-022-35684-6  0.58
2022 Sighel D, Battistini G, Rosatti EF, Vigna J, Pavan M, Belli R, Peroni D, Alessandrini F, Longhi S, Pancher M, Rorbach J, Moro S, Quattrone A, Mancini I. Streptogramin A derivatives as mitochondrial translation inhibitors to suppress glioblastoma stem cell growth. European Journal of Medicinal Chemistry. 246: 114979. PMID 36495628 DOI: 10.1016/j.ejmech.2022.114979  0.418
2022 Clemente P, Calvo-Garrido J, Pearce SF, Schober FA, Shigematsu M, Siira SJ, Laine I, Spåhr H, Steinmetzger C, Petzold K, Kirino Y, Wibom R, Rackham O, Filipovska A, Rorbach J, et al. ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing. Nature Communications. 13: 5750. PMID 36180430 DOI: 10.1038/s41467-022-33368-9  0.446
2021 Cipullo M, Gesé GV, Khawaja A, Hällberg BM, Rorbach J. Structural basis for late maturation steps of the human mitoribosomal large subunit. Nature Communications. 12: 3673. PMID 34135318 DOI: 10.1038/s41467-021-23617-8  0.405
2021 D'Souza AR, Van Haute L, Powell CA, Mutti CD, Páleníková P, Rebelo-Guiomar P, Rorbach J, Minczuk M. YbeY is required for ribosome small subunit assembly and tRNA processing in human mitochondria. Nucleic Acids Research. PMID 34037799 DOI: 10.1093/nar/gkab404  0.805
2021 Lopez Sanchez MIG, Krüger A, Shiriaev DI, Liu Y, Rorbach J. Human Mitoribosome Biogenesis and Its Emerging Links to Disease. International Journal of Molecular Sciences. 22. PMID 33917098 DOI: 10.3390/ijms22083827  0.423
2021 Sighel D, Notarangelo M, Aibara S, Re A, Ricci G, Guida M, Soldano A, Adami V, Ambrosini C, Broso F, Rosatti EF, Longhi S, Buccarelli M, D'Alessandris QG, Giannetti S, ... ... Rorbach J, et al. Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth. Cell Reports. 35: 109024. PMID 33910005 DOI: 10.1016/j.celrep.2021.109024  0.501
2021 Páleníková P, Harbour ME, Ding S, Fearnley IM, Van Haute L, Rorbach J, Scavetta R, Minczuk M, Rebelo-Guiomar P. Quantitative density gradient analysis by mass spectrometry (qDGMS) and complexome profiling analysis (ComPrAn) R package for the study of macromolecular complexes. Biochimica Et Biophysica Acta. Bioenergetics. 1862: 148399. PMID 33592209 DOI: 10.1016/j.bbabio.2021.148399  0.628
2021 Pearce SF, Cipullo M, Chung B, Brierley I, Rorbach J. Mitoribosome Profiling from Human Cell Culture: A High Resolution View of Mitochondrial Translation. Methods in Molecular Biology (Clifton, N.J.). 2192: 183-196. PMID 33230774 DOI: 10.1007/978-1-0716-0834-0_14  0.594
2020 Cipullo M, Pearce SF, Lopez Sanchez IG, Gopalakrishna S, Krüger A, Schober F, Busch JD, Li X, Wredenberg A, Atanassov I, Rorbach J. Human GTPBP5 is involved in the late stage of mitoribosome large subunit assembly. Nucleic Acids Research. PMID 33283228 DOI: 10.1093/nar/gkaa1131  0.463
2020 Abshire ET, Hughes KL, Diao R, Pearce S, Gopalakrishna S, Trievel RC, Rorbach J, Freddolino PL, Goldstrohm AC. Differential processing and localization of human Nocturnin controls metabolism of mRNA and nicotinamide adenine dinucleotide cofactors. The Journal of Biological Chemistry. PMID 32839274 DOI: 10.1074/Jbc.Ra120.012618  0.507
2020 Lopez Sanchez MIG, Cipullo M, Gopalakrishna S, Khawaja A, Rorbach J. Methylation of Ribosomal RNA: A Mitochondrial Perspective. Frontiers in Genetics. 11: 761. PMID 32765591 DOI: 10.3389/Fgene.2020.00761  0.686
2020 Khawaja A, Itoh Y, Remes C, Spåhr H, Yukhnovets O, Höfig H, Amunts A, Rorbach J. Distinct pre-initiation steps in human mitochondrial translation. Nature Communications. 11: 2932. PMID 32522994 DOI: 10.1038/S41467-020-16503-2  0.587
2019 Busch JD, Cipullo M, Atanassov I, Bratic A, Silva Ramos E, Schöndorf T, Li X, Pearce SF, Milenkovic D, Rorbach J, Larsson NG. MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition. Cell Reports. 29: 1728-1738.e9. PMID 31693908 DOI: 10.1016/J.Celrep.2019.09.080  0.567
2019 Gopalakrishna S, Pearce SF, Dinan AM, Schober FA, Cipullo M, Spåhr H, Khawaja A, Maffezzini C, Freyer C, Wredenberg A, Atanassov I, Firth AE, Rorbach J. C6orf203 is an RNA-binding protein involved in mitochondrial protein synthesis. Nucleic Acids Research. 47: 9386-9399. PMID 31396629 DOI: 10.1093/Nar/Gkz684  0.602
2018 Kruppa AJ, Kishi-Itakura C, Masters TA, Rorbach JE, Grice GL, Kendrick-Jones J, Nathan JA, Minczuk M, Buss F. Myosin VI-Dependent Actin Cages Encapsulate Parkin-Positive Damaged Mitochondria. Developmental Cell. PMID 29398621 DOI: 10.1016/J.Devcel.2018.01.007  0.734
2017 Rorbach J, Aibara S, Amunts A. Ribosome origami. Nature Structural & Molecular Biology. 24: 879-881. PMID 29112687 DOI: 10.1038/nsmb.3497  0.391
2017 Patel D, Rorbach J, Downes K, Szukszto MJ, Pekalski ML, Minczuk M. Macropinocytic entry of isolated mitochondria in epidermal growth factor-activated human osteosarcoma cells. Scientific Reports. 7: 12886. PMID 29018288 DOI: 10.1038/S41598-017-13227-0  0.721
2017 Garone C, D'Souza AR, Dallabona C, Lodi T, Rebelo-Guiomar P, Rorbach J, Donati MA, Procopio E, Montomoli M, Guerrini R, Zeviani M, Calvo SE, Mootha VK, DiMauro S, Ferrero I, et al. Defective mitochondrial rRNA methyltransferase MRM2 causes MELAS-like clinical syndrome. Human Molecular Genetics. PMID 28973171 DOI: 10.17863/Cam.13649  0.754
2017 Brown A, Rathore S, Kimanius D, Aibara S, Bai XC, Rorbach J, Amunts A, Ramakrishnan V. Structures of the human mitochondrial ribosome in native states of assembly. Nature Structural & Molecular Biology. PMID 28892042 DOI: 10.1038/Nsmb.3464  0.557
2017 Chrzanowska-Lightowlers Z, Rorbach J, Minczuk M. Human mitochondrial ribosomes can switch structural tRNAs - but when and why? Rna Biology. 14: 1668-1671. PMID 28786741 DOI: 10.1080/15476286.2017.1356551  0.783
2017 Pearce SF, Rorbach J, Van Haute L, D'Souza AR, Rebelo-Guiomar P, Powell CA, Brierley I, Firth AE, Minczuk M. Maturation of selected human mitochondrial tRNAs requires deadenylation. Elife. 6. PMID 28745585 DOI: 10.7554/Elife.27596  0.802
2017 Rozanska A, Richter-Dennerlein R, Rorbach J, Gao F, Lewis RJ, Chrzanowska-Lightowlers ZM, Lightowlers RN. The human RNA-binding protein RBFA promotes the maturation of the mitochondrial ribosome. The Biochemical Journal. PMID 28512204 DOI: 10.1042/Bcj20170256  0.684
2017 Pearce SF, Rorbach J, Haute LV, D’Souza AR, Rebelo-Guiomar P, Powell CA, Brierley I, Firth AE, Minczuk M. Author response: Maturation of selected human mitochondrial tRNAs requires deadenylation Elife. DOI: 10.7554/Elife.27596.025  0.757
2016 Rorbach J, Gao F, Powell CA, D'Souza A, Lightowlers RN, Minczuk M, Chrzanowska-Lightowlers ZM. Human mitochondrial ribosomes can switch their structural RNA composition. Proceedings of the National Academy of Sciences of the United States of America. PMID 27729525 DOI: 10.1073/Pnas.1609338113  0.756
2016 Gammage PA, Gaude E, Van Haute L, Rebelo-Guiomar P, Jackson CB, Rorbach J, Pekalski ML, Robinson AJ, Charpentier M, Concordet JP, Frezza C, Minczuk M. Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs. Nucleic Acids Research. PMID 27466392 DOI: 10.1093/Nar/Gkw676  0.75
2016 Van Haute L, Dietmann S, Kremer L, Hussain S, Pearce SF, Powell CA, Rorbach J, Lantaff R, Blanco S, Sauer S, Kotzaeridou U, Hoffmann GF, Memari Y, Kolb-Kokocinski A, Durbin R, et al. Deficient methylation and formylation of mt-tRNA(Met) wobble cytosine in a patient carrying mutations in NSUN3. Nature Communications. 7: 12039. PMID 27356879 DOI: 10.1038/Ncomms12039  0.751
2016 Karniely S, Weekes MP, Antrobus R, Rorbach J, van Haute L, Umrania Y, Smith DL, Stanton RJ, Minczuk M, Lehner PJ, Sinclair JH. Human Cytomegalovirus Infection Upregulates the Mitochondrial Transcription and Translation Machineries. Mbio. 7. PMID 27025248 DOI: 10.1128/Mbio.00029-16  0.79
2016 Rorbach J, Gammage PA, Minczuk M. C7orf30 is necessary for biogenesis of the large subunit of the mitochondrial ribosome. Nucleic Acids Research. 44: 992. PMID 26487634 DOI: 10.1093/Nar/Gkv1125  0.827
2015 Powell CA, Kopajtich R, D'Souza AR, Rorbach J, Kremer LS, Husain RA, Dallabona C, Donnini C, Alston CL, Griffin H, Pyle A, Chinnery PF, Strom TM, Meitinger T, Rodenburg RJ, et al. TRMT5 Mutations Cause a Defect in Post-transcriptional Modification of Mitochondrial tRNA Associated with Multiple Respiratory-Chain Deficiencies. American Journal of Human Genetics. 97: 319-28. PMID 26189817 DOI: 10.1016/J.Ajhg.2015.06.011  0.795
2014 Kopajtich R, Nicholls TJ, Rorbach J, Metodiev MD, Freisinger P, Mandel H, Vanlander A, Ghezzi D, Carrozzo R, Taylor RW, Marquard K, Murayama K, Wieland T, Schwarzmayr T, Mayr JA, et al. Mutations in GTPBP3 cause a mitochondrial translation defect associated with hypertrophic cardiomyopathy, lactic acidosis, and encephalopathy. American Journal of Human Genetics. 95: 708-20. PMID 25434004 DOI: 10.1016/J.Ajhg.2014.10.017  0.782
2014 Rorbach J, Boesch P, Gammage PA, Nicholls TJ, Pearce SF, Patel D, Hauser A, Perocchi F, Minczuk M. MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome. Molecular Biology of the Cell. 25: 2542-55. PMID 25009282 DOI: 10.1091/Mbc.E14-01-0014  0.828
2014 Dalla Rosa I, Durigon R, Pearce SF, Rorbach J, Hirst EM, Vidoni S, Reyes A, Brea-Calvo G, Minczuk M, Woellhaf MW, Herrmann JM, Huynen MA, Holt IJ, Spinazzola A. MPV17L2 is required for ribosome assembly in mitochondria. Nucleic Acids Research. 42: 8500-15. PMID 24948607 DOI: 10.1093/Nar/Gku513  0.808
2014 Johnson MA, Vidoni S, Durigon R, Pearce SF, Rorbach J, He J, Brea-Calvo G, Minczuk M, Reyes A, Holt IJ, Spinazzola A. Amino acid starvation has opposite effects on mitochondrial and cytosolic protein synthesis. Plos One. 9: e93597. PMID 24718614 DOI: 10.1371/Journal.Pone.0093597  0.682
2014 Rorbach J, Bobrowicz A, Pearce S, Minczuk M. Polyadenylation in bacteria and organelles. Methods in Molecular Biology (Clifton, N.J.). 1125: 211-27. PMID 24590792 DOI: 10.1007/978-1-62703-971-0_18  0.623
2014 Gammage PA, Rorbach J, Vincent AI, Rebar EJ, Minczuk M. Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations. Embo Molecular Medicine. 6: 458-66. PMID 24567072 DOI: 10.1002/Emmm.201303672  0.777
2013 Haack TB, Kopajtich R, Freisinger P, Wieland T, Rorbach J, Nicholls TJ, Baruffini E, Walther A, Danhauser K, Zimmermann FA, Husain RA, Schum J, Mundy H, Ferrero I, Strom TM, et al. ELAC2 mutations cause a mitochondrial RNA processing defect associated with hypertrophic cardiomyopathy. American Journal of Human Genetics. 93: 211-23. PMID 23849775 DOI: 10.1016/J.Ajhg.2013.06.006  0.807
2013 Nicholls TJ, Rorbach J, Minczuk M. Mitochondria: mitochondrial RNA metabolism and human disease. The International Journal of Biochemistry & Cell Biology. 45: 845-9. PMID 23333854 DOI: 10.1016/J.Biocel.2013.01.005  0.793
2013 Kornblum C, Nicholls TJ, Haack TB, Schöler S, Peeva V, Danhauser K, Hallmann K, Zsurka G, Rorbach J, Iuso A, Wieland T, Sciacco M, Ronchi D, Comi GP, Moggio M, et al. Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease Nature Genetics. 45: 214-219. PMID 23313956 DOI: 10.1038/Ng.2501  0.78
2013 Kazak L, Reyes A, Duncan AL, Rorbach J, Wood SR, Brea-Calvo G, Gammage PA, Robinson AJ, Minczuk M, Holt IJ. Alternative translation initiation augments the human mitochondrial proteome. Nucleic Acids Research. 41: 2354-69. PMID 23275553 DOI: 10.1093/Nar/Gks1347  0.811
2013 Kornblum C, Nicholls T, Haack TB, Schoeler S, Peeva V, Danhauser K, Hallmann K, Zsurka G, Rorbach J, Iuso A, Wieland T, Sciacco M, Ronchi D, Comi GP, Moggio M, et al. O.24 Loss of function of MGME1, a novel player in mitochondrial DNA replication, causes a distinct autosomal recessive mitochondrial disorder Neuromuscular Disorders. 23: 852-852. DOI: 10.1016/J.Nmd.2013.06.734  0.771
2012 Rorbach J, Minczuk M. The post-transcriptional life of mammalian mitochondrial RNA. The Biochemical Journal. 444: 357-73. PMID 22642575 DOI: 10.1042/Bj20112208  0.744
2012 Rorbach J, Gammage PA, Minczuk M. C7orf30 is necessary for biogenesis of the large subunit of the mitochondrial ribosome. Nucleic Acids Research. 40: 4097-109. PMID 22238376 DOI: 10.1093/nar/gkr1282  0.818
2011 Rorbach J, Nicholls TJ, Minczuk M. PDE12 removes mitochondrial RNA poly(A) tails and controls translation in human mitochondria. Nucleic Acids Research. 39: 7750-63. PMID 21666256 DOI: 10.1093/Nar/Gkr470  0.774
2010 Ziabreva I, Campbell G, Rist J, Zambonin J, Rorbach J, Wydro MM, Lassmann H, Franklin RJ, Mahad D. Injury and differentiation following inhibition of mitochondrial respiratory chain complex IV in rat oligodendrocytes. Glia. 58: 1827-37. PMID 20665559 DOI: 10.1002/Glia.21052  0.513
2010 Richter R, Rorbach J, Pajak A, Smith PM, Wessels HJ, Huynen MA, Smeitink JA, Lightowlers RN, Chrzanowska-Lightowlers ZM. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. The Embo Journal. 29: 1116-25. PMID 20186120 DOI: 10.1038/Emboj.2010.14  0.588
2010 Rorbach J, Nicholls T, Minczuk M. Polyadenylation of mt mRNA: Identification of novel deadenylase of human mitochondria Biochimica Et Biophysica Acta. 1797: 105. DOI: 10.1016/J.Bbabio.2010.04.317  0.693
2008 Rorbach J, Richter R, Wessels HJ, Wydro M, Pekalski M, Farhoud M, Kühl I, Gaisne M, Bonnefoy N, Smeitink JA, Lightowlers RN, Chrzanowska-Lightowlers ZM. The human mitochondrial ribosome recycling factor is essential for cell viability. Nucleic Acids Research. 36: 5787-99. PMID 18782833 DOI: 10.1093/Nar/Gkn576  0.723
2008 Rorbach J, Yusoff AA, Tuppen H, Abg-Kamaludin DP, Chrzanowska-Lightowlers ZM, Taylor RW, Turnbull DM, McFarland R, Lightowlers RN. Overexpression of human mitochondrial valyl tRNA synthetase can partially restore levels of cognate mt-tRNAVal carrying the pathogenic C25U mutation. Nucleic Acids Research. 36: 3065-74. PMID 18400783 DOI: 10.1093/Nar/Gkn147  0.572
2007 Rorbach J, Soleimanpour-Lichaei R, Lightowlers RN, Chrzanowska-Lightowlers ZMA. How do mammalian mitochondria synthesize proteins Biochemical Society Transactions. 35: 1290-1291. PMID 17956332 DOI: 10.1042/Bst0351290  0.528
2007 Soleimanpour-Lichaei HR, Kühl I, Gaisne M, Passos JF, Wydro M, Rorbach J, Temperley R, Bonnefoy N, Tate W, Lightowlers R, Chrzanowska-Lightowlers Z. mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG. Molecular Cell. 27: 745-57. PMID 17803939 DOI: 10.1016/J.Molcel.2007.06.031  0.589
Show low-probability matches.