Isobel A. Scarisbrick, Ph.D. - Publications

Affiliations: 
Physiology and Biomedical Engineering Mayo Clinic, Rochester, MN, United States 
Area:
Neurobiology

57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Yoon H, Triplet EM, Simon WL, Choi CI, Kleppe LS, De Vita E, Miller AK, Scarisbrick IA. Blocking Kallikrein 6 promotes developmental myelination. Glia. PMID 34626143 DOI: 10.1002/glia.24100  0.415
2021 Langley MR, Choi CI, Peclat TR, Guo Y, Simon W, Yoon H, Kleppe L, Lucchinetti CF, Chini CCS, Chini EN, Scarisbrick IA. Critical Role of Astrocyte NAD Glycohydrolase in Myelin Injury and Regeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 34493542 DOI: 10.1523/JNEUROSCI.2264-20.2021  0.365
2021 Kim HN, Triplet EM, Radulovic M, Bouchal S, Kleppe LS, Simon WL, Yoon H, Scarisbrick IA. The thrombin receptor modulates astroglia-neuron trophic coupling and neural repair after spinal cord injury. Glia. PMID 33887067 DOI: 10.1002/glia.24012  0.801
2021 Triplet EM, Kim HN, Yoon H, Radulovic M, Kleppe L, Simon WL, Choi CI, Walsh PJ, Dutton JR, Scarisbrick IA. The thrombin receptor links brain derived neurotrophic factor to neuron cholesterol production, resiliency and repair after spinal cord injury. Neurobiology of Disease. 105294. PMID 33549720 DOI: 10.1016/j.nbd.2021.105294  0.774
2021 Triplet EM, Scarisbrick IA. Statin use is associated with reduced motor recovery after spinal cord injury. Spinal Cord Series and Cases. 7: 8. PMID 33536407 DOI: 10.1038/s41394-020-00378-y  0.333
2020 Kim HN, Langley MR, Simon WL, Yoon H, Kleppe L, Lanza IR, LeBrasseur NK, Matveyenko A, Scarisbrick IA. A Western diet impairs CNS energy homeostasis and recovery after spinal cord injury: Link to astrocyte metabolism. Neurobiology of Disease. 104934. PMID 32376475 DOI: 10.1016/J.Nbd.2020.104934  0.713
2020 Langley MR, Triplet EM, Scarisbrick IA. Dietary influence on central nervous system myelin production, injury, and regeneration. Biochimica Et Biophysica Acta. Molecular Basis of Disease. 1866: 165779. PMID 32224154 DOI: 10.1016/J.Bbadis.2020.165779  0.377
2020 Yoon H, Choi CI, Triplet EM, Langley MR, Kleppe LS, Kim HN, Simon WL, Scarisbrick IA. Blocking the Thrombin Receptor Promotes Repair of Demyelinated Lesions in the Adult Brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31911460 DOI: 10.1523/Jneurosci.2029-19.2019  0.709
2019 Langley MR, Yoon H, Kim HN, Choi CI, Simon W, Kleppe L, Lanza IR, LeBrasseur NK, Matveyenko A, Scarisbrick IA. High fat diet consumption results in mitochondrial dysfunction, oxidative stress, and oligodendrocyte loss in the central nervous system. Biochimica Et Biophysica Acta. Molecular Basis of Disease. 165630. PMID 31816440 DOI: 10.1016/J.Bbadis.2019.165630  0.68
2019 Wang Y, Hoeppner LH, Angom RS, Wang E, Dutta S, Doeppler HR, Wang F, Shen T, Scarisbrick IA, Guha S, Storz P, Bhattacharya R, Mukhopadhyay D. Protein kinase D up-regulates transcription of VEGF receptor-2 in endothelial cells by suppressing nuclear localization of the transcription factor AP2β. The Journal of Biological Chemistry. PMID 31492751 DOI: 10.1074/Jbc.Ra119.010152  0.375
2019 Kim HN, Yoon H, Langley M, Kleppe L, Matveyenko A, Scarisbrick I. Western diet impairs energy homeostasis in the CNS, drives astrogliosis, and limits recovery of function after experimental spinal cord injury Ibro Reports. 6: S505. DOI: 10.1016/J.Ibror.2019.07.1578  0.687
2018 Eftekhari R, Lima SG, Liu Y, Mihara K, Saifeddine M, Noorbakhsh F, Scarisbrick IA, Hollenberg MD. Microenvironment proteinases, proteinase-activated receptor regulation, cancer and inflammation. Biological Chemistry. PMID 29924723 DOI: 10.1515/Hsz-2018-0001  0.348
2018 Choi CI, Yoon H, Drucker KL, Langley MR, Kleppe L, Scarisbrick IA. The Thrombin Receptor Restricts Subventricular Zone Neural Stem Cell Expansion and Differentiation. Scientific Reports. 8: 9360. PMID 29921916 DOI: 10.1038/S41598-018-27613-9  0.453
2018 Yoon H, Radulovic M, Scarisbrick IA. Kallikrein-related peptidase 6 orchestrates astrocyte form and function through proteinase activated receptor-dependent mechanisms. Biological Chemistry. PMID 29604205 DOI: 10.1515/Hsz-2018-0122  0.698
2017 Yoon H, Radulovic M, Walters G, Paulsen AR, Drucker K, Starski P, Wu J, Fairlie DP, Scarisbrick IA. Protease activated receptor 2 controls myelin development, resiliency and repair. Glia. PMID 28921694 DOI: 10.1002/Glia.23215  0.744
2017 Yoon H, Walters G, Paulsen AR, Scarisbrick IA. Astrocyte heterogeneity across the brain and spinal cord occurs developmentally, in adulthood and in response to demyelination. Plos One. 12: e0180697. PMID 28700615 DOI: 10.1371/Journal.Pone.0180697  0.518
2016 Yoon H, Scarisbrick IA. Kallikrein-related peptidase 6 exacerbates disease in an autoimmune model of multiple sclerosis. Biological Chemistry. PMID 27533119 DOI: 10.1515/Hsz-2016-0239  0.419
2016 Radulovic M, Yoon H, Wu J, Mustafa K, Scarisbrick IA. Targeting the thrombin receptor modulates inflammation and astrogliosis to improve recovery after spinal cord injury. Neurobiology of Disease. PMID 27145117 DOI: 10.1016/J.Nbd.2016.04.010  0.736
2016 Yoon H, Kleven A, Paulsen A, Kleppe L, Wu J, Ying Z, Gomez-Pinilla F, Scarisbrick IA. Interplay between exercise and dietary fat modulates myelinogenesis in the central nervous system. Biochimica Et Biophysica Acta. PMID 26826016 DOI: 10.1016/J.Bbadis.2016.01.019  0.39
2016 Kleven A, Yoon H, Paulsen AR, Horn K, Gomez-Pinilla F, Scarisbrick IA. Exercise Training and Dietary Fat Modulate Myelinogenesis in the Adult Spinal Cord Archives of Physical Medicine and Rehabilitation. 97: e105. DOI: 10.1016/J.Apmr.2016.08.326  0.343
2015 Radulovic M, Yoon H, Wu J, Mustafa K, Fehlings MG, Scarisbrick IA. Genetic Targeting of Protease Activated Receptor 2 Reduces Inflammatory Astrogliosis and Improves Recovery of Function after Spinal Cord Injury. Neurobiology of Disease. PMID 26316358 DOI: 10.1016/J.Nbd.2015.08.021  0.718
2015 Yoon H, Radulovic M, Drucker KL, Wu J, Scarisbrick IA. The thrombin receptor is a critical extracellular switch controlling myelination. Glia. 63: 846-59. PMID 25628003 DOI: 10.1002/Glia.22788  0.734
2014 Panos M, Christophi GP, Rodriguez M, Scarisbrick IA. Differential expression of multiple kallikreins in a viral model of multiple sclerosis points to unique roles in the innate and adaptive immune response. Biological Chemistry. 395: 1063-73. PMID 25153387 DOI: 10.1515/Hsz-2014-0141  0.471
2013 Radulovic M, Yoon H, Larson N, Wu J, Linbo R, Burda JE, Diamandis EP, Blaber SI, Blaber M, Fehlings MG, Scarisbrick IA. Kallikrein cascades in traumatic spinal cord injury: in vitro evidence for roles in axonopathy and neuron degeneration. Journal of Neuropathology and Experimental Neurology. 72: 1072-89. PMID 24128681 DOI: 10.1097/Nen.0000000000000007  0.784
2013 Burda JE, Radulovic M, Yoon H, Scarisbrick IA. Critical role for PAR1 in kallikrein 6-mediated oligodendrogliopathy. Glia. 61: 1456-70. PMID 23832758 DOI: 10.1002/Glia.22534  0.799
2013 Yoon H, Radulovic M, Wu J, Blaber SI, Blaber M, Fehlings MG, Scarisbrick IA. Kallikrein 6 signals through PAR1 and PAR2 to promote neuron injury and exacerbate glutamate neurotoxicity. Journal of Neurochemistry. 127: 283-98. PMID 23647384 DOI: 10.1111/Jnc.12293  0.727
2013 Yoon H, Blaber SI, Li W, Scarisbrick IA, Blaber M. Activation profiles of human kallikrein-related peptidases by matrix metalloproteinases. Biological Chemistry. 394: 137-47. PMID 23241590 DOI: 10.1515/Hsz-2012-0249  0.331
2012 Scarisbrick IA, Radulovic M, Burda JE, Larson N, Blaber SI, Giannini C, Blaber M, Vandell AG. Kallikrein 6 is a novel molecular trigger of reactive astrogliosis. Biological Chemistry. 393: 355-67. PMID 22505518 DOI: 10.1515/Hsz-2011-0241  0.739
2012 Scarisbrick IA, Yoon H, Panos M, Larson N, Blaber SI, Blaber M, Rodriguez M. Kallikrein 6 regulates early CNS demyelination in a viral model of multiple sclerosis. Brain Pathology (Zurich, Switzerland). 22: 709-22. PMID 22335454 DOI: 10.1111/J.1750-3639.2012.00577.X  0.504
2011 Scarisbrick IA, Epstein B, Cloud BA, Yoon H, Wu J, Renner DN, Blaber SI, Blaber M, Vandell AG, Bryson AL. Functional role of kallikrein 6 in regulating immune cell survival. Plos One. 6: e18376. PMID 21464892 DOI: 10.1371/Journal.Pone.0018376  0.728
2010 Blaber M, Yoon H, Juliano MA, Scarisbrick IA, Blaber SI. Functional intersection of the kallikrein-related peptidases (KLKs) and thrombostasis axis. Biological Chemistry. 391: 311-20. PMID 20128685 DOI: 10.1515/Bc.2010.024  0.319
2009 Yoon H, Blaber SI, Debela M, Goettig P, Scarisbrick IA, Blaber M. A completed KLK activome profile: investigation of activation profiles of KLK9, 10, and 15. Biological Chemistry. 390: 373-7. PMID 19090718 DOI: 10.1515/Bc.2009.026  0.351
2008 Vandell AG, Larson N, Laxmikanthan G, Panos M, Blaber SI, Blaber M, Scarisbrick IA. Protease-activated receptor dependent and independent signaling by kallikreins 1 and 6 in CNS neuron and astroglial cell lines. Journal of Neurochemistry. 107: 855-70. PMID 18778305 DOI: 10.1111/J.1471-4159.2008.05658.X  0.756
2008 Yoon H, Blaber SI, Evans DM, Trim J, Juliano MA, Scarisbrick IA, Blaber M. Activation profiles of human kallikrein-related peptidases by proteases of the thrombostasis axis. Protein Science : a Publication of the Protein Society. 17: 1998-2007. PMID 18697857 DOI: 10.1110/Ps.036715.108  0.372
2008 Scarisbrick IA, Linbo R, Vandell AG, Keegan M, Blaber SI, Blaber M, Sneve D, Lucchinetti CF, Rodriguez M, Diamandis EP. Kallikreins are associated with secondary progressive multiple sclerosis and promote neurodegeneration. Biological Chemistry. 389: 739-45. PMID 18627300 DOI: 10.1515/Bc.2008.085  0.734
2008 Scarisbrick IA. The multiple sclerosis degradome: enzymatic cascades in development and progression of central nervous system inflammatory disease. Current Topics in Microbiology and Immunology. 318: 133-75. PMID 18219817  0.302
2007 Yoon H, Laxmikanthan G, Lee J, Blaber SI, Rodriguez A, Kogot JM, Scarisbrick IA, Blaber M. Activation profiles and regulatory cascades of the human kallikrein-related peptidases. The Journal of Biological Chemistry. 282: 31852-64. PMID 17823117 DOI: 10.1074/Jbc.M705190200  0.382
2007 Blaber SI, Yoon H, Scarisbrick IA, Juliano MA, Blaber M. The autolytic regulation of human kallikrein-related peptidase 6. Biochemistry. 46: 5209-17. PMID 17417874 DOI: 10.1021/Bi6025006  0.408
2006 Scarisbrick IA, Sabharwal P, Cruz H, Larsen N, Vandell AG, Blaber SI, Ameenuddin S, Papke LM, Fehlings MG, Reeves RK, Blaber M, Windebank AJ, Rodriguez M. Dynamic role of kallikrein 6 in traumatic spinal cord injury. The European Journal of Neuroscience. 24: 1457-69. PMID 16987227 DOI: 10.1111/J.1460-9568.2006.05021.X  0.772
2006 Oikonomopoulou K, Hansen KK, Saifeddine M, Tea I, Blaber M, Blaber SI, Scarisbrick I, Andrade-Gordon P, Cottrell GS, Bunnett NW, Diamandis EP, Hollenberg MD. Proteinase-activated receptors, targets for kallikrein signaling. The Journal of Biological Chemistry. 281: 32095-112. PMID 16885167 DOI: 10.1074/Jbc.M513138200  0.381
2006 Scarisbrick IA, Blaber SI, Tingling JT, Rodriguez M, Blaber M, Christophi GP. Potential scope of action of tissue kallikreins in CNS immune-mediated disease. Journal of Neuroimmunology. 178: 167-76. PMID 16824622 DOI: 10.1016/J.Jneuroim.2006.05.022  0.409
2006 Oikonomopoulou K, Hansen KK, Saifeddine M, Vergnolle N, Tea I, Blaber M, Blaber SI, Scarisbrick I, Diamandis EP, Hollenberg MD. Kallikrein-mediated cell signalling: targeting proteinase-activated receptors (PARs). Biological Chemistry. 387: 817-24. PMID 16800746 DOI: 10.1515/Bc.2006.104  0.374
2006 Angelo PF, Lima AR, Alves FM, Blaber SI, Scarisbrick IA, Blaber M, Juliano L, Juliano MA. Substrate specificity of human kallikrein 6: salt and glycosaminoglycan activation effects. The Journal of Biological Chemistry. 281: 3116-26. PMID 16321973 DOI: 10.1074/Jbc.M510096200  0.418
2005 Laxmikanthan G, Blaber SI, Bernett MJ, Scarisbrick IA, Juliano MA, Blaber M. 1.70 A X-ray structure of human apo kallikrein 1: structural changes upon peptide inhibitor/substrate binding. Proteins. 58: 802-14. PMID 15651049 DOI: 10.1002/Prot.20368  0.317
2004 Christophi GP, Isackson PJ, Blaber S, Blaber M, Rodriguez M, Scarisbrick IA. Distinct promoters regulate tissue-specific and differential expression of kallikrein 6 in CNS demyelinating disease. Journal of Neurochemistry. 91: 1439-49. PMID 15584920 DOI: 10.1111/J.1471-4159.2004.02826.X  0.316
2004 Blaber SI, Ciric B, Christophi GP, Bernett MJ, Blaber M, Rodriguez M, Scarisbrick IA. Targeting kallikrein 6 proteolysis attenuates CNS inflammatory disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 920-2. PMID 15033932 DOI: 10.1096/Fj.03-1212Fje  0.417
2003 Scarisbrick IA, Rodriguez M. Hit-Hit and hit-Run: viruses in the playing field of multiple sclerosis. Current Neurology and Neuroscience Reports. 3: 265-71. PMID 12760396 DOI: 10.1007/S11910-003-0087-9  0.307
2002 Scarisbrick IA, Blaber SI, Lucchinetti CF, Genain CP, Blaber M, Rodriguez M. Activity of a newly identified serine protease in CNS demyelination. Brain : a Journal of Neurology. 125: 1283-96. PMID 12023317 DOI: 10.1093/Brain/Awf142  0.454
2002 Bernett MJ, Blaber SI, Scarisbrick IA, Dhanarajan P, Thompson SM, Blaber M. Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system. The Journal of Biological Chemistry. 277: 24562-70. PMID 11983703 DOI: 10.1074/Jbc.M202392200  0.325
2002 Blaber SI, Scarisbrick IA, Bernett MJ, Dhanarajan P, Seavy MA, Jin Y, Schwartz MA, Rodriguez M, Blaber M. Enzymatic properties of rat myelencephalon-specific protease. Biochemistry. 41: 1165-73. PMID 11802715 DOI: 10.1021/Bi015781A  0.5
2001 Scarisbrick IA, Isackson PJ, Ciric B, Windebank AJ, Rodriguez M. MSP, a trypsin-like serine protease, is abundantly expressed in the human nervous system. The Journal of Comparative Neurology. 431: 347-61. PMID 11170010 DOI: 10.1002/1096-9861(20010312)431:3<347::Aid-Cne1075>3.0.Co;2-K  0.402
2000 Scarisbrick IA, Asakura K, Blaber S, Blaber M, Isackson PJ, Bieto T, Rodriguez M, Windebank AJ. Preferential expression of myelencephalon-specific protease by oligodendrocytes of the adult rat spinal cord white matter. Glia. 30: 219-30. PMID 10756072 DOI: 10.1002/(Sici)1098-1136(200005)30:3<219::Aid-Glia2>3.0.Co;2-2  0.493
1999 Scarisbrick IA, Isackson PJ, Windebank AJ. Differential expression of brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 in the adult rat spinal cord: regulation by the glutamate receptor agonist kainic acid. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 7757-69. PMID 10479679 DOI: 10.1523/Jneurosci.19-18-07757.1999  0.468
1999 Scarisbrick IA, Isackson PJ, Windebank AJ. Differential Expression of Brain-Derived Neurotrophic Factor, Neurotrophin-3, and Neurotrophin-4/5 in the Adult Rat Spinal Cord: Regulation by the Glutamate Receptor Agonist Kainic Acid The Journal of Neuroscience. 19: 7757-7769. DOI: 10.1523/JNEUROSCI.19-18-07757.1999  0.331
1997 Scarisbrick IA, Towner MD, Isackson PJ. Nervous system-specific expression of a novel serine protease: regulation in the adult rat spinal cord by excitotoxic injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 8156-68. PMID 9334391 DOI: 10.1523/Jneurosci.17-21-08156.1997  0.492
1993 Scarisbrick IA, Jones EG, Isackson PJ. Coexpression of mRNAs for NGF, BDNF, and NT-3 in the cardiovascular system of the pre- and postnatal rat. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 875-93. PMID 8441013 DOI: 10.1523/Jneurosci.13-03-00875.1993  0.384
1993 Scarisbrick IA, Jones EG. NCAM immunoreactivity during major developmental events in the rat maxillary nerve-whisker system. Brain Research. Developmental Brain Research. 71: 121-35. PMID 8431996 DOI: 10.1016/0165-3806(93)90113-O  0.411
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