Neelam Shahani, Ph.D. - Publications

Neuroscience Scripps Florida, Jupiter, FL, United States 
Modulators of neurodegenerative disease relevant biochemical pathways.

28 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Shahani N, Huang WC, Varnum M, Page DT, Subramaniam S. Forebrain depletion of Rheb GTPase elicits spatial memory deficits in mice. Neurobiology of Aging. 50: 134-143. PMID 27960107 DOI: 10.1016/j.neurobiolaging.2016.11.006  0.48
2016 Shahani N, Swarnkar S, Giovinazzo V, Morgenweck J, Bohn LM, Scharager-Tapia C, Pascal B, Martinez-Acedo P, Khare K, Subramaniam S. RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum. Science Signaling. 9: ra111. PMID 27902448 DOI: 10.1126/scisignal.aaf6670  0.48
2016 Kim SH, Shahani N, Bae BI, Sbodio JI, Chung Y, Nakaso K, Paul BD, Sawa A. Allele-specific regulation of mutant Huntingtin by Wig1, a downstream target of p53. Human Molecular Genetics. PMID 27206983 DOI: 10.1093/hmg/ddw115  1
2015 Swarnkar S, Chen Y, Pryor WM, Shahani N, Page DT, Subramaniam S. Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease. Neurobiology of Disease. 82: 66-77. PMID 26048156 DOI: 10.1016/j.nbd.2015.05.011  1
2015 Nakajima H, Kubo T, Ihara H, Hikida T, Danjo T, Nakatsuji M, Shahani N, Itakura M, Ono Y, Azuma YT, Inui T, Kamiya A, Sawa A, Takeuchi T. Nuclear-translocated Glyceraldehyde-3-phosphate Dehydrogenase Promotes Poly(ADP-ribose) Polymerase-1 Activation during Oxidative/Nitrosative Stress in Stroke. The Journal of Biological Chemistry. 290: 14493-503. PMID 25882840 DOI: 10.1074/jbc.M114.635607  1
2015 Tyagi R, Shahani N, Gorgen L, Ferretti M, Pryor W, Chen PY, Swarnkar S, Worley PF, Karbstein K, Snyder SH, Subramaniam S. Rheb Inhibits Protein Synthesis by Activating the PERK-eIF2α Signaling Cascade. Cell Reports. PMID 25660019 DOI: 10.1016/j.celrep.2015.01.014  1
2015 Tristan CA, Ramos A, Shahani N, Emiliani FE, Nakajima H, Noeh CC, Kato Y, Takeuchi T, Noguchi T, Kadowaki H, Sedlak TW, Ishizuka K, Ichijo H, Sawa A. Role of apoptosis signal-regulating kinase 1 (ASK1) as an activator of the GAPDH-Siah1 stress-signaling cascade. The Journal of Biological Chemistry. 290: 56-64. PMID 25391652 DOI: 10.1074/jbc.M114.596205  1
2015 Shahani N, Seshadri S, Jaaro-Peled H, Ishizuka K, Hirota-Tsuyada Y, Wang Q, Koga M, Sedlak TW, Korth C, Brandon NJ, Kamiya A, Subramaniam S, Tomoda T, Sawa A. DISC1 regulates trafficking and processing of APP and Aβ generation. Molecular Psychiatry. 20: 874-9. PMID 25224257 DOI: 10.1038/mp.2014.100  1
2014 Pryor WM, Biagioli M, Shahani N, Swarnkar S, Huang WC, Page DT, MacDonald ME, Subramaniam S. Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease. Science Signaling. 7: ra103. PMID 25351248 DOI: 10.1126/scisignal.2005633  1
2014 Irmady K, Jackman KA, Padow VA, Shahani N, Martin LA, Cerchietti L, Unsicker K, Iadecola C, Hempstead BL. Mir-592 regulates the induction and cell death-promoting activity of p75NTR in neuronal ischemic injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 3419-28. PMID 24573298 DOI: 10.1523/JNEUROSCI.1982-13.2014  1
2014 Shahani N, Pryor W, Swarnkar S, Kholodilov N, Thinakaran G, Burke RE, Subramaniam S. Rheb GTPase regulates β-secretase levels and amyloid β generation. The Journal of Biological Chemistry. 289: 5799-808. PMID 24368770 DOI: 10.1074/jbc.M113.532713  1
2014 Mealer RG, Murray AJ, Shahani N, Subramaniam S, Snyder SH. Rhes, a striatal-selective protein implicated in Huntington disease, binds beclin-1 and activates autophagy. The Journal of Biological Chemistry. 289: 3547-54. PMID 24324270 DOI: 10.1074/jbc.M113.536912  1
2013 Johnson AW, Jaaro-Peled H, Shahani N, Sedlak TW, Zoubovsky S, Burruss D, Emiliani F, Sawa A, Gallagher M. Cognitive and motivational deficits together with prefrontal oxidative stress in a mouse model for neuropsychiatric illness. Proceedings of the National Academy of Sciences of the United States of America. 110: 12462-7. PMID 23840059 DOI: 10.1073/pnas.1307925110  1
2012 Subramaniam S, Napolitano F, Mealer RG, Kim S, Errico F, Barrow R, Shahani N, Tyagi R, Snyder SH, Usiello A. Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA-induced dyskinesia. Nature Neuroscience. 15: 191-3. PMID 22179112 DOI: 10.1038/nn.2994  1
2012 Shahani N, Sawa A. Protein S-nitrosylation: role for nitric oxide signaling in neuronal death. Biochimica Et Biophysica Acta. 1820: 736-42. PMID 21803124 DOI: 10.1016/j.bbagen.2011.07.010  1
2011 Deepa P, Shahani N, Alladi PA, Vijayalakshmi K, Sathyaprabha TN, Nalini A, Ravi V, Raju TR. Down regulation of trophic factors in neonatal rat spinal cord after administration of cerebrospinal fluid from sporadic amyotrophic lateral sclerosis patients. Journal of Neural Transmission (Vienna, Austria : 1996). 118: 531-8. PMID 21069391 DOI: 10.1007/s00702-010-0520-6  1
2011 Shahani N, Sawa A. Nitric oxide signaling and nitrosative stress in neurons: role for S-nitrosylation. Antioxidants & Redox Signaling. 14: 1493-504. PMID 20812870 DOI: 10.1089/ars.2010.3580  1
2011 Tristan C, Shahani N, Sedlak TW, Sawa A. The diverse functions of GAPDH: views from different subcellular compartments. Cellular Signalling. 23: 317-23. PMID 20727968 DOI: 10.1016/j.cellsig.2010.08.003  1
2008 Sen N, Hara MR, Kornberg MD, Cascio MB, Bae BI, Shahani N, Thomas B, Dawson TM, Dawson VL, Snyder SH, Sawa A. Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis. Nature Cell Biology. 10: 866-73. PMID 18552833 DOI: 10.1038/ncb1747  1
2006 Shahani N, Subramaniam S, Wolf T, Tackenberg C, Brandt R. Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 6103-14. PMID 16738255 DOI: 10.1523/JNEUROSCI.4245-05.2006  1
2006 Shahani N, Subramaniam S, Brandt R. Purification of MINUS: A negative regulator of microtubule nucleation in a variety of organisms. International Journal of Biological Macromolecules. 39: 15-22. PMID 16420961 DOI: 10.1016/j.ijbiomac.2005.12.014  1
2005 Subramaniam S, Shahani N, Strelau J, Laliberté C, Brandt R, Kaplan D, Unsicker K. Insulin-like growth factor 1 inhibits extracellular signal-regulated kinase to promote neuronal survival via the phosphatidylinositol 3-kinase/protein kinase A/c-Raf pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2838-52. PMID 15772344 DOI: 10.1523/JNEUROSCI.5060-04.2005  1
2005 Brandt R, Hundelt M, Shahani N. Tau alteration and neuronal degeneration in tauopathies: mechanisms and models. Biochimica Et Biophysica Acta. 1739: 331-54. PMID 15615650 DOI: 10.1016/j.bbadis.2004.06.018  1
2004 Shahani N, Gourie-Devi M, Nalini A, Rammohan P, Shobha K, Harsha HN, Raju TR. (-)-Deprenyl alleviates the degenerative changes induced in the neonatal rat spinal cord by CSF from amyotrophic lateral sclerosis patients. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group On Motor Neuron Diseases. 5: 172-9. PMID 15512906 DOI: 10.1080/14660820410017037  1
2002 Shahani N, Brandt R. Functions and malfunctions of the tau proteins. Cellular and Molecular Life Sciences : Cmls. 59: 1668-80. PMID 12475178  1
2001 Shahani N, Gourie-Devi M, Nalini A, Raju TR. Cyclophosphamide attenuates the degenerative changes induced by CSF from patients with amyotrophic lateral sclerosis in the neonatal rat spinal cord. Journal of the Neurological Sciences. 185: 109-18. PMID 11311291 DOI: 10.1016/S0022-510X(01)00479-8  1
1998 Shahani N, Nalini A, Gourie-Devi M, Raju TR. Reactive astrogliosis in neonatal rat spinal cord after exposure to cerebrospinal fluid from patients with amyotrophic lateral sclerosis. Experimental Neurology. 149: 295-8. PMID 9454639 DOI: 10.1006/exnr.1997.6651  1
1995 Rao MS, Devi MG, Nalini A, Shahani N, Raju TR. Neurofilament phosphorylation is increased in ventral horn neurons of neonatal rat spinal cord exposed to cerebrospinal fluid from patients with amyotrophic lateral sclerosis. Neurodegeneration : a Journal For Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration. 4: 397-401. PMID 8846233 DOI: 10.1006/neur.1995.0048  1
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