| Year |
Citation |
Score |
| 2017 |
Powell DR, Smith MG, Doree DD, Harris AL, Greer J, DaCosta CM, Thompson A, Jeter-Jones S, Xiong W, Carson KG, Goodwin NC, Harrison BA, Rawlins DB, Strobel ED, Gopinathan S, ... ... Zambrowicz B, et al. LX2761, a Sodium/Glucose Cotransporter 1 Inhibitor Restricted to the Intestine, Improves Glycemic Control in Mice. The Journal of Pharmacology and Experimental Therapeutics. PMID 28442582 DOI: 10.1124/Jpet.117.240820 |
0.363 |
|
| 2016 |
Powell DR, Gay JP, Smith M, Wilganowski N, Harris A, Holland A, Reyes M, Kirkham L, Kirkpatrick LL, Zambrowicz B, Hansen G, Platt KA, van Sligtenhorst I, Ding ZM, Desai U. Fatty acid desaturase 1 knockout mice are lean with improved glycemic control and decreased development of atheromatous plaque. Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy. 9: 185-99. PMID 27382320 DOI: 10.2147/Dmso.S106653 |
0.373 |
|
| 2016 |
Vogel P, Read RW, Hansen GM, Powell DR, Kantaputra PN, Zambrowicz B, Brommage R. Dentin Dysplasia in Notum Knockout Mice. Veterinary Pathology. 53: 853-862. PMID 26926082 DOI: 10.1177/0300985815626778 |
0.314 |
|
| 2015 |
Kim JJ, Wang H, Terc JD, Zambrowicz B, Yang QM, Khan WI. Blocking peripheral serotonin synthesis by telotristat etiprate (LX1032/LX1606) reduces severity of both chemical- and infection-induced intestinal inflammation. American Journal of Physiology. Gastrointestinal and Liver Physiology. 309: G455-65. PMID 26206858 DOI: 10.1152/Ajpgi.00299.2014 |
0.302 |
|
| 2015 |
Powell DR, Gay JP, Wilganowski N, Doree D, Savelieva KV, Lanthorn TH, Read R, Vogel P, Hansen GM, Brommage R, Ding ZM, Desai U, Zambrowicz B. Diacylglycerol Lipase α Knockout Mice Demonstrate Metabolic and Behavioral Phenotypes Similar to Those of Cannabinoid Receptor 1 Knockout Mice. Frontiers in Endocrinology. 6: 86. PMID 26082754 DOI: 10.3389/Fendo.2015.00086 |
0.363 |
|
| 2015 |
Powell DR, Smith MG, Doree DD, Harris AL, Xiong WW, Mseeh F, Wilson A, Gopinathan S, Diaz D, Goodwin NC, Harrison B, Strobel E, Rawlins DB, Carson K, Zambrowicz B, et al. LP-925219 maximizes urinary glucose excretion in mice by inhibiting both renal SGLT1 and SGLT2. Pharmacology Research & Perspectives. 3: e00129. PMID 26038705 DOI: 10.1002/Prp2.129 |
0.351 |
|
| 2015 |
Powell DR, Doree D, Jeter-Jones S, Ding ZM, Zambrowicz B, Sands A. Sotagliflozin improves glycemic control in nonobese diabetes-prone mice with type 1 diabetes. Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy. 8: 121-7. PMID 25759591 DOI: 10.2147/Dmso.S76342 |
0.323 |
|
| 2015 |
Lapuerta P, Zambrowicz B, Strumph P, Sands A. Development of sotagliflozin, a dual sodium-dependent glucose transporter 1/2 inhibitor Diabetes and Vascular Disease Research. 12: 101-110. PMID 25690134 DOI: 10.1177/1479164114563304 |
0.328 |
|
| 2014 |
Brommage R, Liu J, Hansen GM, Kirkpatrick LL, Potter DG, Sands AT, Zambrowicz B, Powell DR, Vogel P. High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes. Bone Research. 2: 14034. PMID 26273529 DOI: 10.1038/Boneres.2014.34 |
0.377 |
|
| 2014 |
Powell DR, DaCosta CM, Smith M, Doree D, Harris A, Buhring L, Heydorn W, Nouraldeen A, Xiong W, Yalamanchili P, Mseeh F, Wilson A, Shadoan M, Zambrowicz B, Ding ZM. Effect of LX4211 on glucose homeostasis and body composition in preclinical models. The Journal of Pharmacology and Experimental Therapeutics. 350: 232-42. PMID 24849925 DOI: 10.1124/Jpet.114.214304 |
0.355 |
|
| 2013 |
Zambrowicz B, Ogbaa I, Frazier K, Banks P, Turnage A, Freiman J, Boehm KA, Ruff D, Powell D, Sands A. Effects of LX4211, a dual sodium-dependent glucose cotransporters 1 and 2 inhibitor, on postprandial glucose, insulin, glucagon-like peptide 1, and peptide tyrosine tyrosine in a dose-timing study in healthy subjects. Clinical Therapeutics. 35: 1162-1173.e8. PMID 23911260 DOI: 10.1016/J.Clinthera.2013.06.011 |
0.308 |
|
| 2013 |
Lapuerta P, Rosenstock J, Zambrowicz B, Powell DR, Ogbaa I, Freiman J, Cefalu WT, Banks P, Frazier K, Kelly M, Sands A. Study design and rationale of a dose-ranging trial of LX4211, a dual inhibitor of SGLT1 and SGLT2, in type 2 diabetes inadequately controlled on metformin monotherapy. Clinical Cardiology. 36: 367-71. PMID 23630033 DOI: 10.1002/Clc.22125 |
0.313 |
|
| 2013 |
Powell DR, Smith M, Greer J, Harris A, Zhao S, DaCosta C, Mseeh F, Shadoan MK, Sands A, Zambrowicz B, Ding ZM. LX4211 increases serum glucagon-like peptide 1 and peptide YY levels by reducing sodium/glucose cotransporter 1 (SGLT1)-mediated absorption of intestinal glucose. The Journal of Pharmacology and Experimental Therapeutics. 345: 250-9. PMID 23487174 DOI: 10.1124/Jpet.113.203364 |
0.353 |
|
| 2013 |
Zambrowicz B, Ding ZM, Ogbaa I, Frazier K, Banks P, Turnage A, Freiman J, Smith M, Ruff D, Sands A, Powell D. Effects of LX4211, a dual SGLT1/SGLT2 inhibitor, plus sitagliptin on postprandial active GLP-1 and glycemic control in type 2 diabetes. Clinical Therapeutics. 35: 273-285.e7. PMID 23433601 DOI: 10.1016/J.Clinthera.2013.01.010 |
0.347 |
|
| 2013 |
Powell DR, DaCosta CM, Gay J, Ding ZM, Smith M, Greer J, Doree D, Jeter-Jones S, Mseeh F, Rodriguez LA, Harris A, Buhring L, Platt KA, Vogel P, Brommage R, ... ... Zambrowicz B, et al. Improved glycemic control in mice lacking Sglt1 and Sglt2. American Journal of Physiology. Endocrinology and Metabolism. 304: E117-30. PMID 23149623 DOI: 10.1152/Ajpendo.00439.2012 |
0.303 |
|
| 2013 |
Oravecz T, Chang WC, Jhaver KG, Al-Shami A, Jessop TC, Hamman B, Bagdanoff JT, Augeri DJ, Vogel P, Swaffield J, Wilson A, Carson KG, Main A, Zambrowicz BP. OP0195 Genetic and Pharmacologic Inhibition of MST1 Blocks Lymphocyte Function and Protects Against Inflammation and Autoimmunity Annals of the Rheumatic Diseases. 72. DOI: 10.1136/Annrheumdis-2013-Eular.400 |
0.314 |
|
| 2012 |
Zambrowicz B, Freiman J, Brown PM, Frazier KS, Turnage A, Bronner J, Ruff D, Shadoan M, Banks P, Mseeh F, Rawlins DB, Goodwin NC, Mabon R, Harrison BA, Wilson A, et al. LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial. Clinical Pharmacology and Therapeutics. 92: 158-69. PMID 22739142 DOI: 10.1038/Clpt.2012.58 |
0.321 |
|
| 2011 |
Kulke M, O'Dorisio TM, Phan AT, Langdon RM, Marek BJ, Iklaque N, Bergsland EK, Freiman J, Frazier K, Jackson J, Zambrowicz B. A phase II, multicenter, randomized, double-blind, placebo-controlled, ascending, multidose, U.S. study of oral LX1606 (aka LX1032) in patients with refractory symptomatic carcinoid syndrome. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: TPS168. PMID 28023057 DOI: 10.1200/Jco.2011.29.15_Suppl.Tps168 |
0.305 |
|
| 2011 |
Yoshino H, Miyamae T, Hansen G, Zambrowicz B, Flynn M, Pedicord D, Blat Y, Westphal RS, Zaczek R, Lewis DA, Gonzalez-Burgos G. Postsynaptic diacylglycerol lipase mediates retrograde endocannabinoid suppression of inhibition in mouse prefrontal cortex. The Journal of Physiology. 589: 4857-84. PMID 21807615 DOI: 10.1113/Jphysiol.2011.212225 |
0.307 |
|
| 2011 |
Revelli JP, Smith D, Allen J, Jeter-Jones S, Shadoan MK, Desai U, Schneider M, van Sligtenhorst I, Kirkpatrick L, Platt KA, Suwanichkul A, Savelieva K, Gerhardt B, Mitchell J, Syrewicz J, ... Zambrowicz B, et al. Profound obesity secondary to hyperphagia in mice lacking kinase suppressor of ras 2. Obesity (Silver Spring, Md.). 19: 1010-8. PMID 21127480 DOI: 10.1038/Oby.2010.282 |
0.338 |
|
| 2011 |
Brommage R, Yang Q, Liu J, Mseeh F, Yu W, Jeter-Jones S, Shi Z-, Zambrowicz B, Liu Q, Powell DR. Lack of interaction of serotonin levels and bone mass in LRP5 and TPH1 knockout mice and following pharmacological reduction of intestinal serotonin content Bone. 48. DOI: 10.1016/J.Bone.2011.03.146 |
0.315 |
|
| 2010 |
Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M, Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice DS, ... ... Zambrowicz BP, et al. A mouse knockout library for secreted and transmembrane proteins. Nature Biotechnology. 28: 749-55. PMID 20562862 DOI: 10.1038/Nbt.1644 |
0.385 |
|
| 2010 |
Vogel P, Read R, Hansen GM, Freay LC, Zambrowicz BP, Sands AT. Situs Inversus in Dpcd/Poll–/–, Nme7–/– , and Pkd1l1–/– Mice Veterinary Pathology. 47: 120-131. PMID 20080492 DOI: 10.1177/0300985809353553 |
0.301 |
|
| 2009 |
Sonnenburg WK, Yu D, Lee EC, Xiong W, Gololobov G, Key B, Gay J, Wilganowski N, Hu Y, Zhao S, Schneider M, Ding ZM, Zambrowicz BP, Landes G, Powell DR, et al. GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4 Journal of Lipid Research. 50: 2421-2429. PMID 19542565 DOI: 10.1194/Jlr.M900145-Jlr200 |
0.333 |
|
| 2009 |
Lee EC, Desai U, Gololobov G, Hong S, Feng X, Yu XC, Gay J, Wilganowski N, Gao C, Du LL, Chen J, Hu Y, Zhao S, Kirkpatrick L, Schneider M, ... Zambrowicz BP, et al. Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL). The Journal of Biological Chemistry. 284: 13735-45. PMID 19318355 DOI: 10.1074/Jbc.M807899200 |
0.324 |
|
| 2009 |
Vogel P, Read R, Hansen G, Freay L, Zambrowicz B, Sands A. Situs inversus and related ciliopathies in Dpcd-/-, Pkd1l1-/- and Nme7-/- mice Veterinary Pathology. DOI: 10.1354/Vp.09-Vp-0118-V-Am |
0.309 |
|
| 2009 |
Zambrowicz BP, Sands AT. Chapter 23 A Path to Innovation: Gene Knockouts Model New Drug Action Annual Reports in Medicinal Chemistry. 44: 475-497. DOI: 10.1016/S0065-7743(09)04423-6 |
0.334 |
|
| 2008 |
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells Genome Research. 18: 1670-1679. PMID 18799693 DOI: 10.1101/Gr.078352.108 |
0.346 |
|
| 2008 |
Brommage R, Desai U, Revelli JP, Donoviel DB, Fontenot GK, Dacosta CM, Smith DD, Kirkpatrick LL, Coker KJ, Donoviel MS, Eberhart DE, Holt KH, Kelly MR, Paradee WJ, Philips AV, ... ... Zambrowicz BP, et al. High-throughput screening of mouse knockout lines identifies true lean and obese phenotypes. Obesity (Silver Spring, Md.). 16: 2362-7. PMID 18719666 DOI: 10.1038/Oby.2008.361 |
0.304 |
|
| 2008 |
Liu Q, Yang Q, Sun W, Vogel P, Heydorn W, Yu XQ, Hu Z, Yu W, Jonas B, Pineda R, Calderon-Gay V, Germann M, O'Neill E, Brommage R, Cullinan E, ... ... Zambrowicz B, et al. Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract Journal of Pharmacology and Experimental Therapeutics. 325: 47-55. PMID 18192499 DOI: 10.1124/Jpet.107.132670 |
0.32 |
|
| 2007 |
Desai U, Lee EC, Chung K, Gao C, Gay J, Key B, Hansen G, Machajewski D, Platt KA, Sands AT, Schneider M, Van Sligtenhorst I, Suwanichkul A, Vogel P, Wilganowski N, ... ... Zambrowicz BP, et al. Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice Proceedings of the National Academy of Sciences of the United States of America. 104: 11766-11771. PMID 17609370 DOI: 10.1073/Pnas.0705041104 |
0.344 |
|
| 2007 |
Oravecz T, Donoviel MS, Anderson SJ, Carson K, Sun W, Swaffield J, Liu Q, Kimball SD, Piggott JR, Main AJ, Zambrowicz BP, Sands AT, Turner CA, Augeri DJ. Genetic and Chemical Inhibition of Sphingosine 1-Phosphate Lyase Results in Peripheral Lymphopenia and Alleviates Disease Development in Animal Models of Inflammation and Autoimmunity. Blood. 110: 2292-2292. DOI: 10.1182/Blood.V110.11.2292.2292 |
0.356 |
|
| 2005 |
Zambrowicz B, Kern FG, Zhang N, Brown PM, Sands A. Identification and validation of oncologic disease drug targets by in vivo functional genomic analysis. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 23: 9562. PMID 27944025 DOI: 10.1200/Jco.2005.23.16_Suppl.9562 |
0.354 |
|
| 2004 |
Austin CP, Battey JF, Bradley A, Bucan M, Capecchi M, Collins FS, Dove WF, Duyk G, Dymecki S, Eppig JT, Grieder FB, Heintz N, Hicks G, Insel TR, Joyner A, ... ... Zambrowicz B, et al. The knockout mouse project. Nature Genetics. 36: 921-4. PMID 15340423 DOI: 10.1038/Ng0904-921 |
0.544 |
|
| 2004 |
Rice DS, Huang W, Jones HA, Hansen G, Ye GL, Xu N, Wilson EA, Troughton K, Vaddi K, Newton RC, Zambrowicz BP, Sands AT. Severe retinal degeneration associated with disruption of semaphorin 4A. Investigative Ophthalmology & Visual Science. 45: 2767-77. PMID 15277503 DOI: 10.1167/Iovs.04-0020 |
0.31 |
|
| 2004 |
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, et al. Erratum: Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention (Proceedings of the National Academy of Sciences of the United Stated of America (November 25, 2003) 100, 24 (14109-14114)) Proceedings of the National Academy of Sciences of the United States of America. 101. DOI: 10.1073/Pnas.0400833101 |
0.305 |
|
| 2003 |
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, et al. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proceedings of the National Academy of Sciences of the United States of America. 100: 14109-14. PMID 14610273 DOI: 10.1073/Pnas.2336103100 |
0.383 |
|
| 2002 |
Abuin A, Holt KH, Platt KA, Sands AT, Zambrowicz BP. Full-speed mammalian genetics: in vivo target validation in the drug discovery process. Trends in Biotechnology. 20: 36-42. PMID 11742676 DOI: 10.1016/S0167-7799(01)01843-1 |
0.328 |
|
| 2001 |
Walke DW, Han C, Shaw J, Wann E, Zambrowicz B, Sands A. In vivo drug target discovery: identifying the best targets from the genome. Current Opinion in Biotechnology. 12: 626-631. PMID 11849946 DOI: 10.1016/S0958-1669(01)00271-3 |
0.312 |
|
| 2001 |
Shiels A, Bassnett S, Varadaraj K, Mathias R, Al-Ghoul K, Kuszak J, Donoviel D, Lilleberg S, Friedrich G, Zambrowicz B. Optical dysfunction of the crystalline lens in aquaporin-0-deficient mice Physiological Genomics. 7: 179-186. PMID 11773604 DOI: 10.1152/Physiolgenomics.00078.2001 |
0.307 |
|
| 2001 |
Donoviel DB, Freed DD, Vogel H, Potter DG, Hawkins E, Barrish JP, Mathur BN, Turner CA, Geske R, Montgomery CA, Starbuck M, Brandt M, Gupta A, Ramirez-Solis R, Zambrowicz BP, et al. Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN. Molecular and Cellular Biology. 21: 4829-36. PMID 11416156 DOI: 10.1128/Mcb.21.14.4829-4836.2001 |
0.379 |
|
| 1998 |
Zambrowicz BP, Friedrich GA, Buxton EC, Lilleberg SL, Person C, Sands AT. Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature. 392: 608-11. PMID 9560157 DOI: 10.1038/33423 |
0.319 |
|
| 1998 |
Zambrowicz BP, Friedrich GA. Comprehensive mammalian genetics: history and future prospects of gene trapping in the mouse. The International Journal of Developmental Biology. 42: 1025-1036. DOI: 10.1387/Ijdb.9853834 |
0.341 |
|
| 1997 |
Zambrowicz BP, Imamoto A, Fiering S, Herzenberg LA, Kerr WG, Soriano P. Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells. Proceedings of the National Academy of Sciences of the United States of America. 94: 3789-94. PMID 9108056 DOI: 10.1073/Pnas.94.8.3789 |
0.66 |
|
| 1994 |
Zambrowicz BP, Palmiter RD. Testis-specific and ubiquitous proteins bind to functionally important regions of the mouse protamine-1 promoter. Biology of Reproduction. 50: 65-72. PMID 8312452 DOI: 10.1095/Biolreprod50.1.65 |
0.305 |
|
| 1993 |
Zambrowicz BP, Harendza CJ, Zimmermann JW, Brinster RL, Palmiter RD. Analysis of the mouse protamine 1 promoter in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 90: 5071-5. PMID 8389466 DOI: 10.1073/Pnas.90.11.5071 |
0.367 |
|
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