| Year |
Citation |
Score |
| 2024 |
Li X, Zhou S, Tae HS, Wang S, Li T, Cai W, Jiang T, Adams DJ, Yu R. N-Terminal Capping of the αO-Conotoxin Analogue GeX-2 Improves the Serum Stability and Selectivity toward the Human α9α10 Nicotinic Acetylcholine Receptor. Journal of Medicinal Chemistry. PMID 39361522 DOI: 10.1021/acs.jmedchem.4c01758 |
0.307 |
|
| 2024 |
Li T, Tae HS, Liang J, Zhang Z, Li X, Jiang T, Adams DJ, Yu R. Rational Design of Potent α-Conotoxin PeIA Analogues with Non-Natural Amino Acids for the Inhibition of Human α9α10 Nicotinic Acetylcholine Receptors. Marine Drugs. 22. PMID 38535451 DOI: 10.3390/md22030110 |
0.513 |
|
| 2024 |
Li X, Tae HS, Chen S, Yousuf A, Huang L, Zhang J, Jiang T, Adams DJ, Yu R. Dual Antagonism of α9α10 nAChR and GABA Receptor-Coupled Ca2.2 Channels by an Analgesic αO-Conotoxin Analogue. Journal of Medicinal Chemistry. PMID 38217860 DOI: 10.1021/acs.jmedchem.3c00979 |
0.464 |
|
| 2022 |
Hou X, Li C, Zhang R, Li Y, Li H, Zhang Y, Tae HS, Yu R, Che Q, Zhu T, Li D, Zhang G. Unusual Tetrahydropyridoindole-Containing Tetrapeptides with Human Nicotinic Acetylcholine Receptors Targeting Activity Discovered from Antarctica-Derived Psychrophilic sp. HDN17-933. Marine Drugs. 20. PMID 36286417 DOI: 10.3390/md20100593 |
0.319 |
|
| 2022 |
Liang J, Tae HS, Zhao Z, Li X, Zhang J, Chen S, Jiang T, Adams DJ, Yu R. Mechanism of Action and Structure-Activity Relationship of α-Conotoxin Mr1.1 at the Human α9α10 Nicotinic Acetylcholine Receptor. Journal of Medicinal Chemistry. PMID 36137181 DOI: 10.1021/acs.jmedchem.2c00494 |
0.497 |
|
| 2022 |
Huang Q, Chu X, Zhang H, Yu S, Zhang L, Zhang X, Yu R, Guo C, Dai Q. Discovery and Structural and Functional Characterization of a Novel A-Superfamily Conotoxin Targeting α9α10 Nicotinic Acetylcholine Receptor. Acs Chemical Biology. 17: 2483-2494. PMID 36048451 DOI: 10.1021/acschembio.2c00315 |
0.361 |
|
| 2022 |
Ma Y, Cao Q, Yang M, Gao Y, Fu S, Du W, Adams DJ, Jiang T, Tae HS, Yu R. Single-Disulfide Conopeptide Czon1107, an Allosteric Antagonist of the Human α3β4 Nicotinic Acetylcholine Receptor. Marine Drugs. 20. PMID 36005500 DOI: 10.3390/md20080497 |
0.465 |
|
| 2022 |
Wang S, Bartels P, Zhao C, Yousuf A, Liu Z, Yu S, Bony AR, Ma X, Dai Q, Sun T, Liu N, Yang M, Yu R, Du W, Adams DJ, et al. A 4/8 Subtype α-Conotoxin Vt1.27 Inhibits N-Type Calcium Channels With Potent Anti-Allodynic Effect. Frontiers in Pharmacology. 13: 881732. PMID 35754473 DOI: 10.3389/fphar.2022.881732 |
0.451 |
|
| 2021 |
Zheng M, Tae HS, Xue L, Jiang T, Yu R. Mechanism of interactions between α-conotoxin RegIIA and carbohydrates at the human α3β4 nicotinic acetylcholine receptor. Marine Life Science & Technology. 4: 98-105. PMID 37073352 DOI: 10.1007/s42995-021-00108-9 |
0.386 |
|
| 2021 |
Wei N, Chu Y, Liu H, Xu Q, Jiang T, Yu R. Antagonistic Mechanism of α-Conotoxin BuIA toward the Human α3β2 Nicotinic Acetylcholine Receptor. Acs Chemical Neuroscience. PMID 34738810 DOI: 10.1021/acschemneuro.1c00568 |
0.386 |
|
| 2020 |
Li X, Tae HS, Chu Y, Jiang T, Adams DJ, Yu R. Medicinal chemistry, pharmacology, and therapeutic potential of α-conotoxins antagonizing the α9α10 nicotinic acetylcholine receptor. Pharmacology & Therapeutics. 107792. PMID 33309557 DOI: 10.1016/j.pharmthera.2020.107792 |
0.515 |
|
| 2020 |
Feng L, Sun C, Sun X, Zhao Y, Yu R, Kang C. Identification of inhibitors targeting HIF-2α/c-Myc by molecular docking and MM-GBSA technology. Journal of Receptor and Signal Transduction Research. 1-9. PMID 32981413 DOI: 10.1080/10799893.2020.1825493 |
0.316 |
|
| 2020 |
Li X, Liu H, Gao C, Li Y, Jia D, Yang Y, Yang J, Wei Z, Jiang T, Yu R. ConoMode, a database for conopeptide binding modes. Database : the Journal of Biological Databases and Curation. 2020. PMID 32754758 DOI: 10.1093/Database/Baaa058 |
0.322 |
|
| 2020 |
Xu Q, Tae HS, Wang Z, Jiang T, Adams DJ, Yu R. Rational Design of α-Conotoxin RegIIA Analogues Specifically Inhibiting the Human α3β2 Nicotinic Acetylcholine Receptor through Computational Scanning. Acs Chemical Neuroscience. PMID 32649832 DOI: 10.1021/Acschemneuro.0C00293 |
0.564 |
|
| 2020 |
Chu Y, Qiu P, Yu R. Centipede Venom Peptides Acting on Ion Channels. Toxins. 12. PMID 32260499 DOI: 10.3390/Toxins12040230 |
0.322 |
|
| 2020 |
Liang J, Tae HS, Xu X, Jiang T, Adams DJ, Yu R. Dimerization of α-conotoxins as a strategy to enhance the inhibition of the human α7 and α9α10 nicotinic acetylcholine receptors. Journal of Medicinal Chemistry. PMID 32101438 DOI: 10.1021/Acs.Jmedchem.9B01536 |
0.558 |
|
| 2020 |
Yu R, Wang J, So LY, Harvey PJ, Shi J, Liang J, Dou Q, Li X, Yan X, Huang YH, Xu Q, Kaas Q, Chow HY, Wong KY, Craik DJ, et al. Enhanced Activity against Multi-drug Resistant Bacteria through Coapplication of an Analogue of Tachyplesin I and an Inhibitor of the QseC/B Signaling Pathway. Journal of Medicinal Chemistry. PMID 32003561 DOI: 10.1021/Acs.Jmedchem.9B01563 |
0.307 |
|
| 2020 |
Ding Y, Liu K, Zhao X, Lv Y, Yu R, Kang C. Design, synthesis, and antitumor activity of novel benzoheterocycle derivatives as inhibitors of vascular endothelial growth factor receptor-2 tyrosine kinase Journal of Chemical Research. 44: 286-294. DOI: 10.1177/1747519819899067 |
0.302 |
|
| 2020 |
Yu R, Liu H, Wang B, Harvey PJ, Wei N, Chu Y. Synthesis and biological activity study of the retro-isomer of RhTx against TRPV1 Rsc Advances. 10: 2141-2145. DOI: 10.1039/C9Ra08829F |
0.362 |
|
| 2019 |
Ma H, Qiu P, Harvey PJ, Li X, Zhang Z, Xu Q, Liang J, Kaas Q, Craik DJ, Yang J, Jiang T, Bi X, Yu R. In Silico Design of MDM2-Targeting Peptides from Naturally Occurring Constrained Peptide. Chemmedchem. PMID 31444979 DOI: 10.1002/Cmdc.201900366 |
0.338 |
|
| 2019 |
Chu X, Tae HS, Xu Q, Jiang T, Adams DJ, Yu R. α-Conotoxin Vc1.1 Structure-Activity Relationship at the Human α9α10 Nicotinic Acetylcholine Receptor Investigated by Minimal Side Chain Replacement. Acs Chemical Neuroscience. PMID 31411453 DOI: 10.1021/Acschemneuro.9B00389 |
0.544 |
|
| 2019 |
Zhang S, Song Q, Wang X, Wei Z, Yu R, Wang X, Jiang T. Virtual Screening Guided Design, Synthesis and Bioactivity Study of Benzisoselenazolones (BISAs) on Inhibition of c-Met and Its Downstream Signalling Pathways. International Journal of Molecular Sciences. 20. PMID 31137515 DOI: 10.3390/Ijms20102489 |
0.342 |
|
| 2019 |
Xu X, Liang J, Zhang Z, Jiang T, Yu R. Blockade of Human α7 Nicotinic Acetylcholine Receptor by α-Conotoxin ImI Dendrimer: Insight from Computational Simulations. Marine Drugs. 17. PMID 31126085 DOI: 10.3390/Md17050303 |
0.478 |
|
| 2019 |
Yu R, Tae HS, Xu Q, Craik DJ, Adams DJ, Jiang T, Kaas Q. Molecular dynamics simulations of dihydro-β-erythroidine bound to the human α4β2 nicotinic acetylcholine receptor. British Journal of Pharmacology. PMID 31062355 DOI: 10.1111/Bph.14698 |
0.496 |
|
| 2019 |
Ma H, Qiu P, Xin M, Xu X, Wang Z, Xu H, Yu R, Xu X, Zhao C, Wang X, Guan H, Yang J, Li C. Structure-activity relationship of propylene glycol alginate sodium sulfate derivatives for blockade of selectins binding to tumor cells. Carbohydrate Polymers. 210: 225-233. PMID 30732758 DOI: 10.1016/J.Carbpol.2019.01.024 |
0.326 |
|
| 2019 |
Zhao X, Liu K, Wang X, Yu R, Kang C. Exploration of Novel MTH1 Inhibitors Using Fragment-Based de novo Design, Virtual Screening, and Reverse Virtual Screening Methods Russian Journal of Bioorganic Chemistry. 45: 253-262. DOI: 10.1134/S1068162019040137 |
0.318 |
|
| 2019 |
Wu G, Mai X, Liu F, Lin M, Dong X, Xu Q, Hao C, Zhang L, Yu R, Jiang T. Synthesis of novel 10,11-methylenedioxy-camptothecin glycoside derivatives and investigation of their anti-tumor effects in vivo Rsc Advances. 9: 11142-11150. DOI: 10.1039/C9Ra00315K |
0.309 |
|
| 2019 |
Xu X, Xu Q, Chen F, Shi J, Liu Y, Chu Y, Wan S, Jiang T, Yu R. Role of the disulfide bond on the structure and activity of μ-conotoxin PIIIA in the inhibition of NaV1.4 Rsc Advances. 9: 668-674. DOI: 10.1039/C8Ra06103C |
0.346 |
|
| 2019 |
Yu R, Tae H, Tabassum N, Jiang T, Adams DJ. Interaction mechanism of α-conotoxins to the human α9α10 nAChR subtype Toxicon. 158: S24. DOI: 10.1016/J.Toxicon.2018.10.087 |
0.483 |
|
| 2019 |
Wu G, Xu Q, Bao Y, Liu Y, Li Q, Fang Z, Fu J, Ding Y, Liang Z, Jiang T, Yu R. Differentiation of the Agonists and Antagonists of the α7 Nicotinic Acetylcholine Receptor Journal of Ocean University of China. 18: 1193-1198. DOI: 10.1007/S11802-019-3818-5 |
0.413 |
|
| 2018 |
Jin X, Merrett J, Tong S, Flower B, Xie J, Yu R, Tian S, Gao L, Zhao J, Wang X, Jiang T, Proud CG. Design, synthesis and activity of Mnk1 and Mnk2 selective inhibitors containing thieno[2,3-d]pyrimidine scaffold. European Journal of Medicinal Chemistry. 162: 735-751. PMID 30496989 DOI: 10.1016/J.Ejmech.2018.10.070 |
0.335 |
|
| 2018 |
Li J, Chen Y, Yuan N, Zeng M, Zhao Y, Yu R, Liu Z, Wu H, Dong S. A Novel Natural Influenza A H1N1 Virus Neuraminidase Inhibitory Peptide Derived from Cod Skin Hydrolysates and Its Antiviral Mechanism. Marine Drugs. 16. PMID 30308963 DOI: 10.3390/Md16100377 |
0.313 |
|
| 2018 |
Li J, Liu Z, Zhao Y, Zhu X, Yu R, Dong S, Wu H. Novel Natural Angiotensin Converting Enzyme (ACE)-Inhibitory Peptides Derived from Sea Cucumber-Modified Hydrolysates by Adding Exogenous Proline and a Study of Their Structure⁻Activity Relationship. Marine Drugs. 16. PMID 30081563 DOI: 10.3390/Md16080271 |
0.313 |
|
| 2018 |
Shi J, So LY, Chen F, Liang J, Chow HY, Wong KY, Wan S, Jiang T, Yu R. Influences of disulfide connectivity on structure and antimicrobial activity of tachyplesin I. Journal of Peptide Science : An Official Publication of the European Peptide Society. 24: e3087. PMID 29870123 DOI: 10.1002/Psc.3087 |
0.331 |
|
| 2018 |
Chen F, Huang W, Jiang T, Yu R. Determination of the μ-Conotoxin PIIIA Specificity Against Voltage-Gated Sodium Channels from Binding Energy Calculations. Marine Drugs. 16. PMID 29735899 DOI: 10.3390/Md16050153 |
0.343 |
|
| 2018 |
Yu R, Tae HS, Tabassum N, Shi J, Jiang T, Adams DJ. Molecular determinants conferring the stoichiometric-dependent activity of α-conotoxins at the human α9α10 nicotinic acetylcholine receptor subtype. Journal of Medicinal Chemistry. PMID 29733583 DOI: 10.1021/Acs.Jmedchem.8B00115 |
0.544 |
|
| 2018 |
Zhao M, Wei X, Liu X, Dong X, Yu R, Wan S, Jiang T. Total Synthesis of Marine Cyclic Enol-Phosphotriester Salinipostin Compounds Journal of Ocean University of China. 17: 683-689. DOI: 10.1007/S11802-018-3540-8 |
0.302 |
|
| 2017 |
Tabassum N, Tae HS, Jia X, Kaas Q, Jiang T, Adams DJ, Yu R. Role of Cys-Cys Disulfide Bond on the Structure and Activity of α-Conotoxins at Human Neuronal Nicotinic Acetylcholine Receptors. Acs Omega. 2: 4621-4631. PMID 30023726 DOI: 10.1021/acsomega.7b00639 |
0.433 |
|
| 2017 |
Castro J, Grundy L, Deiteren A, Harrington AM, O'Donnell T, Maddern J, Moore J, Garcia-Caraballo S, Rychkov GY, Yu R, Kaas Q, Craik DJ, Adams DJ, Brierley SM. Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain. British Journal of Pharmacology. PMID 29194563 DOI: 10.1111/Bph.14115 |
0.464 |
|
| 2017 |
Tabassum N, Ma Q, Wu G, Jiang T, Yu R. Exploring the binding energy profiles of full agonists, partial agonists, and antagonists of the α7 nicotinic acetylcholine receptor. Journal of Molecular Modeling. 23: 251. PMID 28770361 DOI: 10.1007/S00894-017-3419-4 |
0.438 |
|
| 2017 |
Ma Q, Tae HS, Wu G, Jiang T, Yu R. Exploring the Relationship between Nicotinic Acetylcholine Receptor Ligand Size, Efficiency, Efficacy and C-loop Opening. Journal of Chemical Information and Modeling. PMID 28718646 DOI: 10.1021/Acs.Jcim.7B00152 |
0.352 |
|
| 2017 |
Xin LT, Liu L, Shao CL, Yu RL, Chen FL, Yue SJ, Wang M, Guo ZL, Fan YC, Guan HS, Wang CY. Discovery of DNA Topoisomerase I Inhibitors with Low-Cytotoxicity Based on Virtual Screening from Natural Products. Marine Drugs. 15. PMID 28698495 DOI: 10.3390/Md15070217 |
0.31 |
|
| 2017 |
Li MJ, Wu GZ, Kaas Q, Jiang T, Yu RL. Development of efficient docking strategies and structure-activity relationship study of the c-Met type II inhibitors. Journal of Molecular Graphics & Modelling. 75: 241-249. PMID 28601708 DOI: 10.1016/J.Jmgm.2017.04.004 |
0.377 |
|
| 2017 |
Cuny H, Yu R, Tae HS, Kompella SN, Adams DJ. α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition. British Journal of Pharmacology. PMID 28477355 DOI: 10.1111/Bph.13852 |
0.557 |
|
| 2017 |
Jiang L, Yin R, Wang X, Dai J, Li J, Jiang T, Yu R. Design and synthesis of neolamellarin a derivatives targeting heat shock protein 90. European Journal of Medicinal Chemistry. 135: 24-33. PMID 28426997 DOI: 10.1016/J.Ejmech.2017.04.019 |
0.332 |
|
| 2017 |
Zhang R, Yu R, Xu Q, Li X, Luo J, Jiang B, Wang L, Guo S, Wu N, Shi D. Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors. European Journal of Medicinal Chemistry. 134: 24-33. PMID 28395151 DOI: 10.1016/J.Ejmech.2017.04.004 |
0.308 |
|
| 2017 |
Safar F, Hurdiss E, Erotocritou M, Greiner T, Lape R, Irvine MW, Fang G, Jane D, Yu R, Dämgen MA, Biggin PC, Sivilotti LG. The startle disease mutation E103K impairs activation of human homomeric α1 glycine receptors by disrupting an intersubunit salt bridge across the agonist binding site. The Journal of Biological Chemistry. PMID 28174298 DOI: 10.1074/Jbc.M116.767616 |
0.361 |
|
| 2016 |
Cuny H, Kompella SN, Tae HS, Yu R, Adams DJ. Key Structural Determinants in the Agonist Binding Loops of Human β2 and β4 Nicotinic Acetylcholine Receptor Subunits Contribute to α3β4 Subtype Selectivity of α-Conotoxins. The Journal of Biological Chemistry. PMID 27646000 DOI: 10.1074/Jbc.M116.730804 |
0.53 |
|
| 2016 |
Liu YZ, Wang XL, Wang XY, Yu RL, Liu DQ, Kang CM. De novo design of VEGFR-2 tyrosine kinase inhibitors based on a linked-fragment approach. Journal of Molecular Modeling. 22: 222. PMID 27558799 DOI: 10.1007/S00894-016-3088-8 |
0.331 |
|
| 2016 |
Yu R, Tabassum N, Jiang T. Investigation of α-conotoxin unbinding using umbrella sampling. Bioorganic & Medicinal Chemistry Letters. PMID 26796065 DOI: 10.1016/J.Bmcl.2016.01.013 |
0.442 |
|
| 2016 |
Braun N, Lynagh T, Yu R, Biggin PC, Pless SA. The role of an absolutely conserved tryptophan pair in the extracellular domain of Cys-loop receptors. Acs Chemical Neuroscience. PMID 26764897 DOI: 10.1021/Acschemneuro.5B00298 |
0.388 |
|
| 2016 |
Zhang R, Chen S, Zhang X, Yu R, Wan S, Geng M, Jiang T. Synthesis and evaluation of novel non-covalent binding quinazoline glycoside derivatives targeting the L858R and T790M variants of EGFR Rsc Advances. 6: 36857-36862. DOI: 10.1039/C6Ra06818A |
0.36 |
|
| 2016 |
Braun N, Lynagh T, Yu R, Biggin PC, Pless SA. The Role of a Tryptophan Cluster in the Extracelluar Domain of Cys-Loop Receptors Biophysical Journal. 110: 602a. DOI: 10.1016/J.Bpj.2015.11.3216 |
0.424 |
|
| 2016 |
Tabassum N, Yu R, Jiang T. Computational determination of the binding mode of α-conotoxin to nicotinic acetylcholine receptor Journal of Ocean University of China. 15: 1027-1033. DOI: 10.1007/S11802-016-3049-Y |
0.478 |
|
| 2015 |
Yu R, Seymour VA, Berecki G, Jia X, Akcan M, Adams DJ, Kaas Q, Craik DJ. Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1. Scientific Reports. 5: 13264. PMID 26290113 DOI: 10.1038/Srep13264 |
0.506 |
|
| 2015 |
Liu S, Wang W, Jiang L, Wan S, Zhang L, Yu R, Jiang T. 2-Pyridinyl-4(3H)-Quinazolinone: A Scaffold for Anti-influenza A Virus Compounds. Chemical Biology & Drug Design. PMID 26017319 DOI: 10.1111/Cbdd.12589 |
0.303 |
|
| 2015 |
Kang CM, Liu DQ, Wang XY, Yu RL, Lv YT. The unbinding studies of vascular endothelial growth factor receptor-2 protein tyrosine kinase type II inhibitors. Journal of Molecular Graphics & Modelling. 59: 130-5. PMID 25989626 DOI: 10.1016/J.Jmgm.2015.04.011 |
0.358 |
|
| 2015 |
Hurdiss EJ, Greiner T, Yu R, Biggin PC, Sivilotti LG. The Kinetic Properties of the Human Glycine Receptor in Response to Different Agonists Biophysical Journal. 108: 432. DOI: 10.1016/J.Bpj.2014.11.2360 |
0.44 |
|
| 2015 |
Yu R, Biggin PC. Conformational Dynamics in the GABAA Receptor Biophysical Journal. 108: 192a. DOI: 10.1016/J.Bpj.2014.11.1062 |
0.366 |
|
| 2014 |
Yu R, Hurdiss E, Greiner T, Lape R, Sivilotti L, Biggin PC. Agonist and antagonist binding in human glycine receptors. Biochemistry. 53: 6041-51. PMID 25184435 DOI: 10.1021/Bi500815F |
0.398 |
|
| 2014 |
Shao S, Yu R, Yu Y, Li Y. Dual-inhibitors of STAT5 and STAT3: studies from molecular docking and molecular dynamics simulations. Journal of Molecular Modeling. 20: 2399. PMID 25098340 DOI: 10.1007/S00894-014-2399-X |
0.356 |
|
| 2014 |
Yu R. Towards Understanding the Interaction of Agonists with the Human α1 Glycine Receptor Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.3048 |
0.427 |
|
| 2014 |
Greiner T, Hurdiss E, Yu R, Lape R, Biggin PC, Sivilotti LG. Interaction of the Glycine Receptor Alpha 1 Binding Site with Partial Agonists Biophysical Journal. 106: 547a. DOI: 10.1016/J.Bpj.2013.11.3047 |
0.428 |
|
| 2013 |
Yu R, Kompella SN, Adams DJ, Craik DJ, Kaas Q. Determination of the α-conotoxin Vc1.1 binding site on the α9α10 nicotinic acetylcholine receptor. Journal of Medicinal Chemistry. 56: 3557-67. PMID 23566299 DOI: 10.1021/Jm400041H |
0.499 |
|
| 2013 |
Shi C, Yu R, Shao S, Li Y. Partial activation of α7 nicotinic acetylcholine receptors: insights from molecular dynamics simulations. Journal of Molecular Modeling. 19: 871-8. PMID 23086458 DOI: 10.1007/S00894-012-1618-6 |
0.467 |
|
| 2012 |
Yu R, Kaas Q, Craik DJ. Delineation of the unbinding pathway of α-conotoxin ImI from the α7 nicotinic acetylcholine receptor. The Journal of Physical Chemistry. B. 116: 6097-105. PMID 22571488 DOI: 10.1021/Jp301352D |
0.456 |
|
| 2011 |
Yu R, Craik DJ, Kaas Q. Blockade of neuronal α7-nAchR by α-Conotoxin ImI explained by computational scanning and energy calculations Plos Computational Biology. 7. PMID 21390272 DOI: 10.1371/Journal.Pcbi.1002011 |
0.468 |
|
| 2010 |
Sun S, Yu R, Zhang Y, Li Y. Molecular dynamic simulation on the conformation of mouse muscle type nAChR Frontiers of Chemical Engineering in China. 4: 348-352. DOI: 10.1007/S11705-009-0284-4 |
0.368 |
|
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