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Rudiger Ernst Kohling, MD PhD - Publications

Affiliations: 
1991-2002 Physiology University of Munster, Münster, Nordrhein-Westfalen, Germany 
 1993-1994 Neurophysiology and Neurology McGill (Montreal Neurological Institute) 
 1998-1998 Neurscience University of Birmingham (UK) 
 2002-2004 Epileptology University of Bonn, Bonn, Nordrhein-Westfalen, Germany 
 2004- Physiology University of Rostock, Rostock, Mecklenburg-Vorpommern, Germany 
Area:
epilepsy, dystonia, ageing
Website:
http://physiologie.med.uni-rostock.de/
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64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Kirschstein T, Köhling R. Functional changes in neuronal circuits due to antibody-driven autoimmune response. Neurobiology of Disease. 184: 106221. PMID 37414365 DOI: 10.1016/j.nbd.2023.106221  0.608
2022 Frerker B, Fiedler S, Kirschstein T, Lange F, Porath K, Sellmann T, Kutzner L, Wilde F, Moosmann J, Köhling R, Hildebrandt G, Schültke E. Effects of Microbeam Irradiation on Rodent Esophageal Smooth Muscle Contraction. Cells. 12. PMID 36611969 DOI: 10.3390/cells12010176  0.537
2022 Küpper M, Porath K, Sellmann T, Bien CG, Köhling R, Kirschstein T. GluN2B inhibition rescues impaired potentiation and epileptogenicity at associational-commissural CA3 synapses in a model of anti-NMDAR encephalitis. Neuroscience Letters. 795: 137031. PMID 36574811 DOI: 10.1016/j.neulet.2022.137031  0.622
2022 Hörnschemeyer J, Kirschstein T, Reichart G, Sasse C, Venus J, Einsle A, Porath K, Linnebacher M, Köhling R, Lange F. Studies on Biological and Molecular Effects of Small-Molecule Kinase Inhibitors on Human Glioblastoma Cells and Organotypic Brain Slices. Life (Basel, Switzerland). 12. PMID 36013437 DOI: 10.3390/life12081258  0.568
2022 Lange F, Kirschstein T, Davis J, Paino J, Barnes M, Klein M, Porath K, Stöhlmacher P, Fiedler S, Frank M, Köhling R, Hildebrandt G, Hausermann D, Lerch M, Schültke E. Microbeam irradiation of the beating rodent heart: an ex vivo study of acute and subacute effects on cardiac function. International Journal of Radiation Oncology, Biology, Physics. PMID 35533907 DOI: 10.1016/j.ijrobp.2022.05.001  0.528
2022 Lange F, Venus J, Shams Esfand Abady D, Porath K, Einsle A, Sellmann T, Neubert V, Reichart G, Linnebacher M, Köhling R, Kirschstein T. Galvanotactic Migration of Glioblastoma and Brain Metastases Cells. Life (Basel, Switzerland). 12. PMID 35455071 DOI: 10.3390/life12040580  0.571
2021 Laker D, Tolle F, Stegen M, Heerdegen M, Köhling R, Kirschstein T, Wolfart J. K7 and K6 Channels Shape the Slow AHP in Mouse Dentate Gyrus Granule Cells and Control Burst-like Firing Behavior. Neuroscience. 467: 56-72. PMID 34048798 DOI: 10.1016/j.neuroscience.2021.05.025  0.592
2021 Müller L, Kirschstein T, Köhling R, Kuhla A, Teipel S. Neuronal Hyperexcitability in APPSWE/PS1dE9 Mouse Models of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 33843674 DOI: 10.3233/JAD-201540  0.554
2020 Lange F, Hartung J, Liebelt C, Boisserée J, Resch T, Porath K, Hörnschemeyer J, Reichart G, Sellmann T, Neubert V, Kriesen S, Hildebrandt G, Schültke E, Köhling R, Kirschstein T. Perampanel Add-on to Standard Radiochemotherapy Promotes Neuroprotection in a Rodent F98 Glioma Model. Frontiers in Neuroscience. 14: 598266. PMID 33328869 DOI: 10.3389/fnins.2020.598266  0.576
2020 Madadi A, Wolfart J, Lange F, Brehme H, Linnebacher M, Bräuer AU, Büttner A, Freiman T, Henker C, Einsle A, Rackow S, Köhling R, Kirschstein T, Müller S. Correlation between Kir4.1 expression and barium-sensitive currents in rat and human glioma cell lines. Neuroscience Letters. 135481. PMID 33161102 DOI: 10.1016/j.neulet.2020.135481  0.583
2020 Henke C, Töllner K, van Dijk RM, Miljanovic N, Cordes T, Twele F, Bröer S, Ziesak V, Rohde M, Hauck SM, Vogel C, Welzel L, Schumann T, Willmes DM, Kurzbach A, et al. Disruption of the sodium-dependent citrate transporter SLC13A5 in mice causes alterations in brain citrate levels and neuronal network excitability in the hippocampus. Neurobiology of Disease. 105018. PMID 32682952 DOI: 10.1016/J.Nbd.2020.105018  0.37
2020 Kirschstein T, Sadkiewicz E, Hund-Göschel G, Becker J, Guli X, Müller S, Rohde M, Hübner DC, Brehme H, Kolbaske S, Porath K, Sellmann T, Großmann A, Wittstock M, Syrbe S, et al. Stereotactically Injected Kv1.2 and CASPR2 Antisera Cause Differential Effects on CA1 Synaptic and Cellular Excitability, but Both Enhance the Vulnerability to Pro-epileptic Conditions. Frontiers in Synaptic Neuroscience. 12: 13. PMID 32269520 DOI: 10.3389/Fnsyn.2020.00013  0.614
2020 Schulze F, Müller S, Guli X, Schumann L, Brehme H, Riffert T, Rohde M, Goerss D, Rackow S, Einsle A, Kirschstein T, Köhling R. CK2 Inhibition Prior to Status Epilepticus Persistently Enhances K2 Function in CA1 Which Slows Down Disease Progression. Frontiers in Cellular Neuroscience. 14: 33. PMID 32174814 DOI: 10.3389/Fncel.2020.00033  0.637
2020 Frerker B, Rohde M, Müller S, Bien CG, Köhling R, Kirschstein T. Distinct Effects of Stereotactically Injected Human Cerebrospinal Fluid Containing Glutamic Acid Decarboxylase Antibodies into the Hippocampus of Rats on the Development of Spontaneous Epileptic Activity. Brain Sciences. 10. PMID 32098388 DOI: 10.3390/Brainsci10020123  0.633
2019 Baruah J, Vasudevan A, Köhling R. Vascular Integrity and Signaling Determining Brain Development, Network Excitability, and Epileptogenesis. Frontiers in Physiology. 10: 1583. PMID 32038280 DOI: 10.3389/Fphys.2019.01583  0.573
2019 Rohde M, Ziebart J, Kirschstein T, Sellmann T, Porath K, Kühl F, Delenda B, Bahls C, van Rienen U, Bader R, Köhling R. Human Osteoblast Migration in DC Electrical Fields Depends on Store Operated Ca-Release and Is Correlated to Upregulation of Stretch-Activated TRPM7 Channels. Frontiers in Bioengineering and Biotechnology. 7: 422. PMID 31921825 DOI: 10.3389/Fbioe.2019.00422  0.602
2019 Mayer J, Kirschstein T, Resch T, Porath K, Krause BJ, Köhling R, Lange F. Perampanel attenuates epileptiform phenotype in C6 glioma. Neuroscience Letters. 134629. PMID 31734290 DOI: 10.1016/J.Neulet.2019.134629  0.751
2019 Köhling R. Translational perspectives: Interneurones start seizures. The Journal of Physiology. PMID 31603536 DOI: 10.1113/Jp278966  0.328
2019 Zschorlich VR, Hillebrecht M, Tanjour T, Qi F, Behrendt F, Kirschstein T, Köhling R. Repetitive Peripheral Magnetic Nerve Stimulation (rPMS) as Adjuvant Therapy Reduces Skeletal Muscle Reflex Activity. Frontiers in Neurology. 10: 930. PMID 31507528 DOI: 10.3389/Fneur.2019.00930  0.577
2019 Kersten M, Rabbe T, Blome R, Porath K, Sellmann T, Bien CG, Köhling R, Kirschstein T. Novel Object Recognition in Rats With NMDAR Dysfunction in CA1 After Stereotactic Injection of Anti-NMDAR Encephalitis Cerebrospinal Fluid. Frontiers in Neurology. 10: 586. PMID 31231304 DOI: 10.3389/Fneur.2019.00586  0.617
2019 Lange F, Weßlau K, Porath K, Hörnschemeyer J, Bergner C, Krause BJ, Mullins CS, Linnebacher M, Köhling R, Kirschstein T. AMPA receptor antagonist perampanel affects glioblastoma cell growth and glutamate release in vitro. Plos One. 14: e0211644. PMID 30716120 DOI: 10.1371/Journal.Pone.0211644  0.628
2018 Reichart G, Mayer J, Zehm C, Kirschstein T, Tokay T, Lange F, Baltrusch S, Tiedge M, Fuellen G, Ibrahim S, Köhling R. Mitochondrial complex IV mutation increases ROS production and reduces lifespan in aged mice. Acta Physiologica (Oxford, England). e13214. PMID 30376218 DOI: 10.1111/Apha.13214  0.688
2018 Bajorat R, Porath K, Kuhn J, Goßla E, Goerss D, Sellmann T, Köhling R, Kirschstein T. Oral administration of the casein kinase 2 inhibitor TBB leads to persistent K2.2 channel up-regulation in the epileptic CA1 area and cortex, but lacks anti-seizure efficacy in the pilocarpine epilepsy model. Epilepsy Research. 147: 42-50. PMID 30219695 DOI: 10.1016/J.Eplepsyres.2018.08.012  0.646
2018 Blome R, Bach W, Guli X, Porath K, Sellmann T, Bien CG, Köhling R, Kirschstein T. Differentially Altered NMDAR Dependent and Independent Long-Term Potentiation in the CA3 Subfield in a Model of Anti-NMDAR Encephalitis. Frontiers in Synaptic Neuroscience. 10: 26. PMID 30108497 DOI: 10.3389/Fnsyn.2018.00026  0.631
2018 Mader F, Müller S, Krause L, Springer A, Kernig K, Protzel C, Porath K, Rackow S, Wittstock T, Frank M, Hakenberg OW, Köhling R, Kirschstein T. Hyperpolarization-Activated Cyclic Nucleotide-Gated Non-selective (HCN) Ion Channels Regulate Human and Murine Urinary Bladder Contractility. Frontiers in Physiology. 9: 753. PMID 29971015 DOI: 10.3389/Fphys.2018.00753  0.598
2018 Müller S, Guli X, Hey J, Einsle A, Pfanz D, Sudmann V, Kirschstein T, Köhling R. Acute epileptiform activity induced by gabazine involves proteasomal rather than lysosomal degradation of KCa2.2 channels. Neurobiology of Disease. PMID 29330041 DOI: 10.1016/J.Nbd.2018.01.005  0.648
2018 Lange F, Porath K, Hartung J, Resch T, Weßlau K, Hörnschemeyer J, Linnebacher M, Schültke E, Kirschstein T, Köhling R. P18. Effekte von Perampanel auf die Gliom-assoziierte Epilepsie Clinical Neurophysiology. 129: e74. DOI: 10.1016/J.Clinph.2018.04.660  0.661
2017 Dammann F, Kirschstein T, Guli X, Müller S, Porath K, Rohde M, Tokay T, Köhling R. Bidirectional shift of group III metabotropic glutamate receptor-mediated synaptic depression in the epileptic hippocampus. Epilepsy Research. PMID 29224956 DOI: 10.1016/J.Eplepsyres.2017.12.002  0.617
2017 Neumann AM, Abele J, Kirschstein T, Engelmann R, Sellmann T, Köhling R, Müller-Hilke B. Mycophenolate mofetil prevents the delayed T cell response after pilocarpine-induced status epilepticus in mice. Plos One. 12: e0187330. PMID 29182639 DOI: 10.1371/Journal.Pone.0187330  0.587
2017 Rehberg M, Kirschstein T, Guli X, Müller S, Rohde M, Franz D, Tokay T, Köhling R. Functional Metaplasticity of Hippocampal Schaffer Collateral-CA1 Synapses Is Reversed in Chronically Epileptic Rats. Neural Plasticity. 2017: 8087401. PMID 29098091 DOI: 10.1155/2017/8087401  0.608
2017 Li S, Kumar T P, Joshee S, Kirschstein T, Subburaju S, Khalili JS, Kloepper J, Du C, Elkhal A, Szabó G, Jain RK, Köhling R, Vasudevan A. Endothelial cell-derived GABA signaling modulates neuronal migration and postnatal behavior. Cell Research. PMID 29086765 DOI: 10.1038/Cr.2017.135  0.684
2016 Hirose M, Schilf P, Lange F, Mayer J, Reichart G, Maity P, Jöhren O, Schwaninger M, Scharffetter-Kochanek K, Sina C, Sadik CD, Köhling R, Miroux B, Ibrahim SM. Uncoupling protein 2 protects mice from aging. Mitochondrion. PMID 27364833 DOI: 10.1016/J.Mito.2016.06.004  0.589
2016 Hackert JK, Müller L, Rohde M, Bien CG, Köhling R, Kirschstein T. Anti-GAD65 Containing Cerebrospinal Fluid Does not Alter GABAergic Transmission. Frontiers in Cellular Neuroscience. 10: 130. PMID 27242441 DOI: 10.3389/Fncel.2016.00130  0.736
2016 Köhling R, Wolfart J. Potassium Channels in Epilepsy. Cold Spring Harbor Perspectives in Medicine. 6. PMID 27141079 DOI: 10.1101/Cshperspect.A022871  0.341
2016 Avoli M, De Curtis M, Gnatkovsky V, Gotman J, Köhling R, Lévesque M, Manseau F, Shiri Z, Williams S. Specific imbalance of excitatory/inhibitory signaling establishes seizure onset pattern in temporal lobe epilepsy. Journal of Neurophysiology. jn.01128.2015. PMID 27075542 DOI: 10.1152/Jn.01128.2015  0.666
2016 Mader F, Krause L, Tokay T, Hakenberg OW, Köhling R, Kirschstein T. P2Y receptor-mediated transient relaxation of rat longitudinal ileum preparations involves phospholipase C activation, intracellular Ca(2+) release and SK channel activation. Acta Pharmacologica Sinica. PMID 27018177 DOI: 10.1038/Aps.2015.137  0.616
2016 Bajorat R, Goerss D, Brenndörfer L, Schwabe L, Köhling R, Kirschstein T. Interplay between interictal spikes and behavioral seizures in young, but not aged pilocarpine-treated epileptic rats. Epilepsy & Behavior : E&B. 57: 90-94. PMID 26926072 DOI: 10.1016/J.Yebeh.2016.01.014  0.637
2016 Guli X, Tokay T, Kirschstein T, Köhling R. Status Epilepticus Enhances Depotentiation after Fully Established LTP in an NMDAR-Dependent but GluN2B-Independent Manner. Neural Plasticity. 2016: 6592038. PMID 26881126 DOI: 10.1155/2016/6592038  0.63
2016 Avchalumov Y, Kirschstein T, Köhling R. Loss of GABAergic control of corticostriatal LTP following status epilepticus Translational Brain Rhythmicity. 1. DOI: 10.15761/TBR.1000102  0.558
2015 Würdemann T, Kersten M, Tokay T, Guli X, Kober M, Rohde M, Porath K, Sellmann T, Bien CG, Köhling R, Kirschstein T. Stereotactic injection of cerebrospinal fluid from anti-NMDA receptor encephalitis into rat dentate gyrus impairs NMDA receptor function. Brain Research. PMID 26721688 DOI: 10.1016/J.Brainres.2015.12.027  0.649
2015 Köhling R, D'Antuono M, Benini R, de Guzman P, Avoli M. Hypersynchronous ictal onset in the perirhinal cortex results from dynamic weakening in inhibition. Neurobiology of Disease. 87: 1-10. PMID 26699817 DOI: 10.1016/J.Nbd.2015.12.002  0.774
2015 Fuellen G, Schofield P, Flatt T, Schulz RJ, Boege F, Kraft K, Rimbach G, Ibrahim S, Tietz A, Schmidt C, Köhling R, Simm A. Living Long and Well: Prospects for a Personalized Approach to the Medicine of Ageing. Gerontology. PMID 26675034 DOI: 10.1159/000442746  0.482
2015 Kirschstein T, Sahre T, Kernig K, Protzel C, Porath K, Köhling R, Hakenberg OW. Inverse relationship of Rho kinase and myosin-light chain kinase expression in the aging human detrusor smooth muscle. Bmc Urology. 15: 104. PMID 26468005 DOI: 10.1186/S12894-015-0098-2  0.583
2015 Kirschstein T, Köhling R. Animal models of tumour-associated epilepsy. Journal of Neuroscience Methods. PMID 26092434 DOI: 10.1016/J.Jneumeth.2015.06.008  0.629
2015 Mayer J, Reichart G, Tokay T, Lange F, Baltrusch S, Junghanss C, Wolkenhauer O, Jaster R, Kunz M, Tiedge M, Ibrahim S, Fuellen G, Köhling R. Reduced adolescent-age spatial learning ability associated with elevated juvenile-age superoxide levels in complex I mouse mutants. Plos One. 10: e0123863. PMID 25853418 DOI: 10.1371/Journal.Pone.0123863  0.597
2015 Weller J, Pose M, Protzel C, Mader F, Porath K, Köhling R, Hakenberg OW, Kirschstein T. Age-related decrease of adenosine-mediated relaxation in rat detrusor is a result of A2B receptor downregulation. International Journal of Urology : Official Journal of the Japanese Urological Association. 22: 322-9. PMID 25728851 DOI: 10.1111/Iju.12679  0.592
2015 Kirschstein T, Tokay T, Rohde M, Zschorlich V, Köhling R. V39. Repetitive magnetic stimulation (rMS) leads to NMDA receptor-dependent metaplasticity in hippocampal slices in vitro Clinical Neurophysiology. 126: e85-e86. DOI: 10.1016/J.Clinph.2015.04.117  0.637
2014 Tokay T, Kirschstein T, Rohde M, Zschorlich V, Köhling R. NMDA receptor-dependent metaplasticity by high-frequency magnetic stimulation. Neural Plasticity. 2014: 684238. PMID 25405036 DOI: 10.1155/2014/684238  0.631
2014 Köhling R. Prolonged seizures: what are the mechanisms that predispose or cease to be protective? A review of animal data. Epileptic Disorders : International Epilepsy Journal With Videotape. 16: 23-36. PMID 25323573 DOI: 10.1684/Epd.2014.0692  0.353
2011 Barmashenko G, Hefft S, Aertsen A, Kirschstein T, Köhling R. Positive shifts of the GABAA receptor reversal potential due to altered chloride homeostasis is widespread after status epilepticus. Epilepsia. 52: 1570-8. PMID 21899534 DOI: 10.1111/J.1528-1167.2011.03247.X  0.627
2011 Köhling R, Staley K. Network mechanisms for fast ripple activity in epileptic tissue. Epilepsy Research. 97: 318-23. PMID 21470826 DOI: 10.1016/J.Eplepsyres.2011.03.006  0.342
2011 Protzel C, Kirschstein T, Porath K, Sellmann T, Köhling R, Hakenberg O. UP-03.203 Role of Myosin Light Chain Kinase in Carbachol-Induced Contractions of Human Detrusor Mooth Muscle Urology. 78: S412. DOI: 10.1016/J.Urology.2011.07.1291  0.571
2006 Köhling R. Pathophysiologie der Epilepsie Klinische Neurophysiologie. 37: 216-224. DOI: 10.1055/S-2006-951902  0.316
2006 Köhling R, Schwartzkroin PA, Avoli M. Studying Epilepsy in the Human Brain In Vitro Models of Seizures and Epilepsy. 89-101. DOI: 10.1016/B978-012088554-1/50010-4  0.466
2002 Köhling R, Straub H, Speckmann EJ. Postoperative investigations in epilepsy surgery - Bioelectrical analyses with conventional methods and voltage-sensitive dyes Klinische Neurophysiologie. 33: 163-167. DOI: 10.1055/S-2002-34828  0.582
2002 Speckmann EJ, Köhling R. Examinations of live human brain tissues Klinische Neurophysiologie. 33: 119. DOI: 10.1055/s-2002-34825  0.437
1996 Lücke A, Köhling R, Speckmann EJ. Effects of glutamate application on the rhythm of low magnesium-induced epileptiform activity in hippocampal slices of guinea-pigs. The European Journal of Neuroscience. 8: 2137-48. PMID 8921305 DOI: 10.1111/J.1460-9568.1996.Tb00735.X  0.58
1996 Köhling R, Lücke A, Straub H, Speckmann EJ. A portable chamber for long-distance transport of surviving human brain slice preparations. Journal of Neuroscience Methods. 67: 233-6. PMID 8872890 DOI: 10.1016/0165-0270(96)00072-6  0.524
1995 Fauteck JD, Bockmann J, Böckers TM, Wittkowski W, Köhling R, Lücke A, Straub H, Speckmann EJ, Tuxhorn I, Wolf P. Melatonin reduces low-Mg2+ epileptiform activity in human temporal slices. Experimental Brain Research. 107: 321-5. PMID 8773250 DOI: 10.1007/Bf00230052  0.518
1994 Schulze-Bonhage A, Köhling R, Straub H, Speckmann EJ. Flunarizine shows increased antiepileptic efficacy with elevated K+ levels in low magnesium induced epileptic activity (neocortical slices, guinea pig). Neuropharmacology. 33: 613-8. PMID 7936095 DOI: 10.1016/0028-3908(94)90165-1  0.51
1994 Straub H, Köhling R, Speckmann EJ. Picrotoxin-induced epileptic activity in hippocampal and neocortical slices (guinea pig): suppression by organic calcium channel blockers. Brain Research. 658: 119-26. PMID 7834332 DOI: 10.1016/S0006-8993(09)90017-8  0.498
1994 Köhling R, Straub H, Speckmann EJ. Spontaneous and stimulus-triggered epileptic discharges: delayed antiepileptic effect with triggering. Experimental Brain Research. 100: 376-84. PMID 7813676 DOI: 10.1007/Bf02738398  0.486
1993 Speckmann EJ, Straub H, Köhling R. Contribution of calcium ions to the generation of epileptic activity and antiepileptic calcium antagonism. Neuropsychobiology. 27: 122-6. PMID 8232825 DOI: 10.1159/000118966  0.456
1992 Straub H, Köhling R, Speckmann EJ. Low magnesium induced epileptiform discharges in neocortical slices (guinea pig): increased antiepileptic efficacy of organic calcium antagonist verapamil with elevation of extracellular K+ concentration. Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology. 103: 57-63. PMID 1360377 DOI: 10.1016/0742-8413(92)90228-Y  0.48
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