| Year |
Citation |
Score |
| 2024 |
Ledergor G, Fan Z, Wu K, McCarthy E, Hyrenius-Wittsten A, Starzinski A, Chang H, Bridge M, Kwek SS, Cheung A, Bylsma SA, Hansen E, Wolf JL, Wong SW, Shah N, ... Roybal KT, et al. CD4+ CAR-T cell exhaustion associated with early relapse of multiple myeloma after BCMA CAR-T cell therapy. Blood Advances. PMID 38574299 DOI: 10.1182/bloodadvances.2023012416 |
0.486 |
|
| 2024 |
Garcia J, Daniels J, Lee Y, Zhu I, Cheng K, Liu Q, Goodman D, Burnett C, Law C, Thienpont C, Alavi J, Azimi C, Montgomery G, Roybal KT, Choi J. Naturally occurring T cell mutations enhance engineered T cell therapies. Nature. 626: 626-634. PMID 38326614 DOI: 10.1038/s41586-024-07018-7 |
0.494 |
|
| 2023 |
Garcia JM, Burnett CE, Roybal KT. Toward the clinical development of synthetic immunity to cancer. Immunological Reviews. PMID 37491719 DOI: 10.1111/imr.13245 |
0.389 |
|
| 2023 |
Zhu I, Piraner DI, Roybal KT. Synthesizing a Smarter CAR T Cell: Advanced Engineering of T-cell Immunotherapies. Cancer Immunology Research. OF1-OF14. PMID 37429007 DOI: 10.1158/2326-6066.CIR-22-0962 |
0.549 |
|
| 2022 |
Allen GM, Frankel NW, Reddy NR, Bhargava HK, Yoshida MA, Stark SR, Purl M, Lee J, Yee JL, Yu W, Li AW, Garcia KC, El-Samad H, Roybal KT, Spitzer MH, et al. Synthetic cytokine circuits that drive T cells into immune-excluded tumors. Science (New York, N.Y.). 378: eaba1624. PMID 36520915 DOI: 10.1126/science.aba1624 |
0.692 |
|
| 2022 |
Li HS, Israni DV, Gagnon KA, Gan KA, Raymond MH, Sander JD, Roybal KT, Joung JK, Wong WW, Khalil AS. Multidimensional control of therapeutic human cell function with synthetic gene circuits. Science (New York, N.Y.). 378: 1227-1234. PMID 36520914 DOI: 10.1126/science.ade0156 |
0.387 |
|
| 2022 |
Beppler C, Eichorst J, Marchuk K, Cai E, Castellanos CA, Sriram V, Roybal KT, Krummel MF. Hyperstabilization of T cell microvilli contacts by chimeric antigen receptors. The Journal of Cell Biology. 222. PMID 36520493 DOI: 10.1083/jcb.202205118 |
0.45 |
|
| 2022 |
Goodman DB, Azimi CS, Kearns K, Talbot A, Garakani K, Garcia J, Patel N, Hwang B, Lee D, Park E, Vykunta VS, Shy BR, Ye CJ, Eyquem J, Marson A, ... ... Roybal KT, et al. Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies. Science Translational Medicine. 14: eabm1463. PMID 36350984 DOI: 10.1126/scitranslmed.abm1463 |
0.494 |
|
| 2022 |
Shemesh A, Su Y, Calabrese DR, Chen D, Arakawa-Hoyt J, Roybal KT, Heath JR, Greenland JR, Lanier LL. Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FcεRIγ expression. The Journal of Experimental Medicine. 219. PMID 36066491 DOI: 10.1084/jem.20220551 |
0.328 |
|
| 2022 |
Shin J, Parker MFL, Zhu I, Alanizi A, Rodriguez CI, Liu R, Watchmaker PB, Kalita M, Blecha J, Luu J, Wright B, Lapi SE, Flavell RR, Okada H, Tlsty TD, ... Roybal KT, et al. Antigen-dependent inducible T cell reporter system for PET imaging of breast cancer and glioblastoma. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 35981900 DOI: 10.2967/jnumed.122.264284 |
0.47 |
|
| 2022 |
Zhu I, Liu R, Garcia JM, Hyrenius-Wittsten A, Piraner DI, Alavi J, Israni DV, Liu B, Khalil AS, Roybal KT. Modular design of synthetic receptors for programmed gene regulation in cell therapies. Cell. 185: 1431-1443.e16. PMID 35427499 DOI: 10.1016/j.cell.2022.03.023 |
0.436 |
|
| 2021 |
Cable J, Leonard JN, Lu TK, Xie Z, Chang MW, Fernández LÁ, Lora JM, Kaufman HL, Quintana FJ, Geiger R, F Lesser C, Lynch JP, Hava DL, Cornish VW, Lee GK, ... ... Roybal KT, et al. Synthetic biology: at the crossroads of genetic engineering and human therapeutics-a Keystone Symposia report. Annals of the New York Academy of Sciences. PMID 34786712 DOI: 10.1111/nyas.14710 |
0.721 |
|
| 2021 |
Hyrenius-Wittsten A, Su Y, Park M, Garcia JM, Alavi J, Perry N, Montgomery G, Liu B, Roybal KT. SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models. Science Translational Medicine. 13. PMID 33910981 DOI: 10.1126/scitranslmed.abd8836 |
0.542 |
|
| 2021 |
Choe JH, Watchmaker PB, Simic MS, Gilbert RD, Li AW, Krasnow NA, Downey KM, Yu W, Carrera DA, Celli A, Cho J, Briones JD, Duecker JM, Goretsky YE, Dannenfelser R, ... ... Roybal KT, et al. SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma. Science Translational Medicine. 13. PMID 33910979 DOI: 10.1126/scitranslmed.abe7378 |
0.72 |
|
| 2020 |
Huang X, Williams JZ, Chang R, Li Z, Burnett CE, Hernandez-Lopez R, Setiady I, Gai E, Patterson DM, Yu W, Roybal KT, Lim WA, Desai TA. DNA scaffolds enable efficient and tunable functionalization of biomaterials for immune cell modulation. Nature Nanotechnology. PMID 33318641 DOI: 10.1038/s41565-020-00813-z |
0.739 |
|
| 2020 |
Williams JZ, Allen GM, Shah D, Sterin IS, Kim KH, Garcia VP, Shavey GE, Yu W, Puig-Saus C, Tsoi J, Ribas A, Roybal KT, Lim WA. Precise T cell recognition programs designed by transcriptionally linking multiple receptors. Science (New York, N.Y.). 370: 1099-1104. PMID 33243890 DOI: 10.1126/science.abc6270 |
0.689 |
|
| 2020 |
Ramkumar P, Abarientos AB, Tian R, Seyler M, Leong JT, Chen M, Choudhry P, Hechler T, Shah N, Wong SW, Martin TG, Wolf JL, Roybal KT, Pahl A, Taunton J, et al. CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma. Blood Advances. 4: 2899-2911. PMID 32589729 DOI: 10.1182/Bloodadvances.2019001346 |
0.485 |
|
| 2020 |
Landgraf KE, Williams SR, Steiger D, Gebhart D, Lok S, Martin DW, Roybal KT, Kim KC. convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting. Communications Biology. 3: 296. PMID 32518350 DOI: 10.1038/s42003-020-1021-2 |
0.545 |
|
| 2020 |
Roth TL, Li PJ, Blaeschke F, Nies JF, Apathy R, Mowery C, Yu R, Nguyen MLT, Lee Y, Truong A, Hiatt J, Wu D, Nguyen DN, Goodman D, Bluestone JA, ... ... Roybal K, et al. Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies. Cell. PMID 32302591 DOI: 10.1016/J.Cell.2020.03.039 |
0.542 |
|
| 2020 |
Watchmaker P, Choe J, Simic M, Gilbert R, li A, Krasnow N, Carrera D, Yu W, Downey K, Celli A, Cho J, Briones J, Dannenfelser R, Cardarelli L, Sidhu S, ... Roybal K, et al. IMMU-33. MULTI-ANTIGEN RECOGNITION CIRCUITS OVERCOME CHALLENGES OF SPECIFICITY, HETEROGENEITY, AND DURABILITY IN T-CELL THERAPY FOR GLIOBLASTOMA Neuro-Oncology. 22: ii111-ii112. DOI: 10.1093/neuonc/noaa215.463 |
0.538 |
|
| 2020 |
Dietrich A, Burnett C, Martin T, Wiita A, Roybal K, Eyquem J. MM-378: Inhibitory and Stimulatory Interplay Between Myeloma Tumor and T Cells Clinical Lymphoma Myeloma and Leukemia. 20: S309. DOI: 10.1016/s2152-2650(20)30958-7 |
0.424 |
|
| 2019 |
Hyrenius-Wittsten A, Roybal KT. Paving New Roads for CARs. Trends in Cancer. 5: 583-592. PMID 31706506 DOI: 10.1016/j.trecan.2019.09.005 |
0.566 |
|
| 2019 |
Azimi CS, Tang Q, Roybal KT, Bluestone JA. NextGen cell-based immunotherapies in cancer and other immune disorders. Current Opinion in Immunology. 59: 79-87. PMID 31071513 DOI: 10.1016/J.Coi.2019.03.007 |
0.465 |
|
| 2019 |
Pai CS, Huang JT, Lu X, Simons DM, Park C, Chang A, Tamaki W, Liu E, Roybal KT, Seagal J, Chen M, Hagihara K, Wei XX, DuPage M, Kwek SS, et al. Clonal Deletion of Tumor-Specific T Cells by Interferon-γ Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade. Immunity. PMID 30737146 DOI: 10.1016/j.immuni.2019.01.006 |
0.467 |
|
| 2019 |
Shemesh A, Roybal KT, Lanier LL. Abstract B044: Engineering CAR NK cells for antigen-dependent autocrine expansion Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-B044 |
0.462 |
|
| 2019 |
Watchmaker P, Choe J, Carrera D, Gilbert R, Yu W, Downey K, Roybal K, Lim W, Okada H. IMMU-21. SEQUENTIAL TWO-RECEPTOR PRIMING CAR SYSTEM TO OVERCOME HETEROGENEOUS ANTIGEN EXPRESSION Neuro-Oncology. 21: vi123-vi123. DOI: 10.1093/neuonc/noz175.514 |
0.656 |
|
| 2019 |
Low-Nam ST, Lin JJ, McAffee DB, Alvarez SA, Hansen SD, Roybal KT, Groves JT. Beyond the TCR, Antigen Discrimination in T Cells Continues in the LAT:GRB2:SOS Protein Condensate Biophysical Journal. 116: 530a. DOI: 10.1016/J.Bpj.2018.11.2856 |
0.438 |
|
| 2018 |
Ramkumar P, Leong J, Seyler M, Georgoulis SJ, Hyrenius Wittsten A, Choudhry P, Roybal K, Wiita AP, Kampmann M. Identifying Factors in Multiple Myeloma Controlling Response to B-Cell Maturation Antigen (BCMA)-Targeted Immunotherapy Using CRISPR-Based Functional Genomics Blood. 132: 1926-1926. DOI: 10.1182/Blood-2018-99-115368 |
0.537 |
|
| 2018 |
Watchmaker P, Choe J, Carrera D, Downey K, Shahin M, Roybal K, Lim W, Okada H. IMMU-57. SEQUENTIAL TWO-RECEPTOR PRIMING CAR SYSTEM TO OVERCOME HETEROGENEOUS ANTIGEN EXPRESSION Neuro-Oncology. 20: vi134-vi134. DOI: 10.1093/Neuonc/Noz175.514 |
0.592 |
|
| 2017 |
Roybal KT, Lim WA. Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities. Annual Review of Immunology. 35: 229-253. PMID 28446063 DOI: 10.1146/Annurev-Immunol-051116-052302 |
0.598 |
|
| 2017 |
Rupp LJ, Schumann K, Roybal KT, Gate RE, Ye CJ, Lim WA, Marson A. CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells. Scientific Reports. 7: 737. PMID 28389661 DOI: 10.1038/S41598-017-00462-8 |
0.667 |
|
| 2016 |
Wayne G, Graves A, Hassabis D, Saha S, Weber CA, Hyman AA, Juelicher F, Stroud DA, Ryan MT, Potvin-Trottier L, Paulsson J, Geiler-Samerotte KA, Siegal ML, Uhlen M, Edfors F, ... ... Roybal K, et al. Principles of Systems Biology, No. 11 Cell Systems. 3: 406-410. PMID 27883884 DOI: 10.1016/J.Cels.2016.11.010 |
0.516 |
|
| 2016 |
Roybal KT, Williams JZ, Morsut L, Rupp LJ, Kolinko I, Choe JH, Walker WJ, McNally KA, Lim WA. Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors. Cell. PMID 27693353 DOI: 10.1016/J.Cell.2016.09.011 |
0.715 |
|
| 2016 |
Roybal KT, Buck TE, Ruan X, Cho BH, Clark DJ, Ambler R, Tunbridge HM, Zhang J, Verkade P, Wülfing C, Murphy RF. Computational spatiotemporal analysis identifies WAVE2 and cofilin as joint regulators of costimulation-mediated T cell actin dynamics. Science Signaling. 9: rs3. PMID 27095595 DOI: 10.1126/scisignal.aad4149 |
0.386 |
|
| 2016 |
Roybal KT, Rupp LJ, Morsut L, Walker WJ, McNally KA, Park JS, Lim WA. Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits. Cell. PMID 26830879 DOI: 10.1016/J.Cell.2016.01.011 |
0.735 |
|
| 2016 |
Morsut L, Roybal KT, Xiong X, Gordley RM, Coyle SM, Thomson M, Lim WA. Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors. Cell. PMID 26830878 DOI: 10.1016/J.Cell.2016.01.012 |
0.599 |
|
| 2015 |
Wu CY, Roybal KT, Puchner EM, Onuffer J, Lim WA. Remote control of therapeutic T cells through a small molecule-gated chimeric receptor. Science (New York, N.Y.). PMID 26405231 DOI: 10.1126/Science.Aab4077 |
0.775 |
|
| 2015 |
Roybal KT, Mace EM, Clark DJ, Leard AD, Herman A, Verkade P, Orange JS, Wülfing C. Modest Interference with Actin Dynamics in Primary T Cell Activation by Antigen Presenting Cells Preferentially Affects Lamellal Signaling. Plos One. 10: e0133231. PMID 26237588 DOI: 10.1371/Journal.Pone.0133231 |
0.407 |
|
| 2015 |
Roybal KT, Mace EM, Mantell JM, Verkade P, Orange JS, Wülfing C. Early Signaling in Primary T Cells Activated by Antigen Presenting Cells Is Associated with a Deep and Transient Lamellal Actin Network. Plos One. 10: e0133299. PMID 26237050 DOI: 10.1371/Journal.Pone.0133299 |
0.433 |
|
| 2015 |
Wu CY, Rupp LJ, Roybal KT, Lim WA. Synthetic biology approaches to engineer T cells. Current Opinion in Immunology. 35: 123-130. PMID 26218616 DOI: 10.1016/J.Coi.2015.06.015 |
0.685 |
|
| 2014 |
Furlan SN, Mandraju R, Brewer T, Roybal K, Troutman TD, Hu W, Palm NW, Unni A, Pasare C. Enhancement of anti-tumor CD8 immunity by IgG1-mediated targeting of Fc receptors Mabs. 6: 108-118. PMID 24284965 DOI: 10.4161/Mabs.27052 |
0.545 |
|
| 2013 |
Roybal KT, Sinai P, Verkade P, Murphy RF, Wülfing C. The actin-driven spatiotemporal organization of T-cell signaling at the system scale. Immunological Reviews. 256: 133-47. PMID 24117818 DOI: 10.1111/imr.12103 |
0.367 |
|
| 2010 |
Sinai P, Roybal KT, Wülfing C. Tentative and transient natural killer cell polarization balances the requirements for discriminatory recognition and cytolytic efficacy. Communicative & Integrative Biology. 3: 545-8. PMID 21331235 DOI: 10.4161/cib.3.6.12843 |
0.358 |
|
| 2010 |
Roybal KT, Wülfing C. Inhibiting the inhibitor of the inhibitor: blocking PKC-theta to enhance regulatory T cell function. Science Signaling. 3: pe24. PMID 20664063 DOI: 10.1126/scisignal.3132pe24 |
0.462 |
|
| 2009 |
Singleton KL, Roybal KT, Sun Y, Fu G, Gascoigne NR, van Oers NS, Wülfing C. Spatiotemporal patterning during T cell activation is highly diverse. Science Signaling. 2: ra15. PMID 19351954 DOI: 10.1126/Scisignal.2000199 |
0.454 |
|
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