☰

Greg Thurber - Publications

Affiliations: 
2008 Chemical Engineering Massachusetts Institute of Technology, Cambridge, MA, United States 
Tree Info Similar researchers PubMed Report error

38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Kopp A, Kwon H, Johnston C, Vance S, Legg J, Galson-Holt L, Thurber GM. Impact of tissue penetration and albumin binding on design of T cell targeted bispecific agents. Neoplasia (New York, N.Y.). 48: 100962. PMID 38183712 DOI: 10.1016/j.neo.2023.100962  0.343
2023 Nessler I, Rubahamya B, Kopp A, Hofsess S, Cardillo TM, Sathyanarayan N, Donnell J, Govindan SV, Thurber GM. Improving Intracellular Delivery of an Antibody-Drug Conjugate Targeting Carcinoembryonic Antigen Increases Efficacy at Clinically Relevant Doses In Vivo. Molecular Cancer Therapeutics. PMID 37913500 DOI: 10.1158/1535-7163.MCT-23-0437  0.632
2023 Khera E, Kim J, Stein A, Ratanapanichkich M, Thurber GM. . The Journal of Pharmacology and Experimental Therapeutics. PMID 37105581 DOI: 10.1124/jpet.122.001540  0.513
2023 de Bever L, Popal S, van Schaik J, Rubahamya B, van Delft FL, Thurber GM, van Berkel SS. Generation of DAR1 Antibody-Drug Conjugates for Ultrapotent Payloads Using Tailored GlycoConnect Technology. Bioconjugate Chemistry. 34: 538-548. PMID 36857521 DOI: 10.1021/acs.bioconjchem.2c00611  0.574
2022 Menezes B, Khera E, Calopiz M, Smith MD, Ganno ML, Cilliers C, Abu-Yousif AO, Linderman JJ, Thurber GM. Pharmacokinetics and Pharmacodynamics of TAK-164 Antibody Drug Conjugate Coadministered with Unconjugated Antibody. The Aaps Journal. 24: 107. PMID 36207468 DOI: 10.1208/s12248-022-00756-4  0.628
2022 Kopp A, Hofsess S, Cardillo TM, Govindan SV, Donnell J, Thurber GM. Antibody Drug Conjugate Sacituzumab Govitecan Drives Efficient Tissue Penetration and Rapid Intracellular Drug Release. Molecular Cancer Therapeutics. PMID 36190986 DOI: 10.1158/1535-7163.MCT-22-0375  0.437
2022 Evans R, Thurber GM. Design of high avidity and low affinity antibodies for in situ control of antibody drug conjugate targeting. Scientific Reports. 12: 7677. PMID 35538109 DOI: 10.1038/s41598-022-11648-0  0.549
2022 Menezes B, Linderman JJ, Thurber GM. Simulating the Selection of Resistant Cells with Bystander Killing and Antibody Coadministration in Heterogeneous Human Epidermal Growth Factor Receptor 2-Positive Tumors. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 50: 8-16. PMID 34649966 DOI: 10.1124/dmd.121.000503  0.488
2021 Khera E, Dong S, Huang H, de Bever L, Delft FLV, Thurber GM. Cellular-Resolution Imaging of Bystander Payload Tissue Penetration from Antibody-Drug Conjugates. Molecular Cancer Therapeutics. PMID 34911819 DOI: 10.1158/1535-7163.MCT-21-0580  0.5
2021 Nessler I, Menezes B, Thurber GM. Key metrics to expanding the pipeline of successful antibody-drug conjugates. Trends in Pharmacological Sciences. 42: 803-812. PMID 34456094 DOI: 10.1016/j.tips.2021.07.005  0.575
2020 Khera E, Cilliers C, Smith MD, Ganno ML, Lai KC, Keating TA, Kopp A, Nessler I, Abu-Yousif AO, Thurber GM. Quantifying ADC bystander payload penetration with cellular resolution using pharmacodynamic mapping. Neoplasia (New York, N.Y.). 23: 210-221. PMID 33385970 DOI: 10.1016/j.neo.2020.12.001  0.557
2020 Ponte JF, Lanieri L, Khera E, Laleau R, Ab O, Espelin C, Kohli N, Matin B, Setiady Y, Miller ML, Keating TA, Chari R, Pinkas J, Gregory R, Thurber GM. Antibody Co-Administration Can Improve Systemic and Local Distribution of Antibody Drug Conjugates to Increase In Vivo Efficacy. Molecular Cancer Therapeutics. PMID 33177153 DOI: 10.1158/1535-7163.MCT-20-0451  0.632
2020 Lu G, Nishio N, van den Berg NS, Martin BA, Fakurnejad S, van Keulen S, Colevas AD, Thurber GM, Rosenthal EL. Co-administered antibody improves penetration of antibody-dye conjugate into human cancers with implications for antibody-drug conjugates. Nature Communications. 11: 5667. PMID 33168818 DOI: 10.1038/s41467-020-19498-y  0.603
2020 Nessler I, Cilliers C, Thurber GM. Practical Guide for Quantification of In Vivo Degradation Rates for Therapeutic Proteins with Single-Cell Resolution Using Fluorescence Ratio Imaging. Pharmaceutics. 12. PMID 32033318 DOI: 10.3390/pharmaceutics12020132  0.318
2020 Menezes B, Cilliers C, Wessler T, Thurber GM, Linderman JJ. An Agent-Based Systems Pharmacology Model of the Antibody-Drug Conjugate Kadcyla to Predict Efficacy of Different Dosing Regimens. The Aaps Journal. 22: 29. PMID 31942650 DOI: 10.1208/s12248-019-0391-1  0.472
2020 Nessler I, Khera E, Vance S, Kopp A, Qiu Q, Keating TA, Abu-Yousif AO, Sandal T, Legg J, Thompson L, Goodwin N, Thurber GM. Increased Tumor Penetration of Single-Domain Antibody Drug Conjugates Improves In Vivo Efficacy in Prostate Cancer Models. Cancer Research. PMID 31941698 DOI: 10.1158/0008-5472.CAN-19-2295  0.421
2020 Singh AP, Guo L, Verma A, Wong GG, Thurber GM, Shah DK. Antibody Coadministration as a Strategy to Overcome Binding-Site Barrier for ADCs: a Quantitative Investigation. The Aaps Journal. 22: 28. PMID 31938899 DOI: 10.1208/s12248-019-0387-x  0.544
2019 Kopp A, Thurber GM. Severing Ties: Quantifying the Payload Release from Antibody Drug Conjugates. Cell Chemical Biology. 26: 1631-1633. PMID 31951577 DOI: 10.1016/j.chembiol.2019.12.001  0.358
2018 Khera E, Thurber GM. Pharmacokinetic and Immunological Considerations for Expanding the Therapeutic Window of Next-Generation Antibody-Drug Conjugates. Biodrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. 32: 465-480. PMID 30132210 DOI: 10.1007/s40259-018-0302-5  0.418
2018 Bartelink IH, Jones EF, Shahidi-Latham SK, Rong ELP, Zheng Y, Vicini P, van 't Veer L, Wolf D, Iagaru A, Kroetz DL, Prideaux B, Cilliers C, Thurber G, Wimana Z, Gebhart G. Tumor drug penetration measurements could be the neglected piece of the personalized cancer treatment puzzle. Clinical Pharmacology and Therapeutics. PMID 30107040 DOI: 10.1002/Cpt.1211  0.364
2018 Nessler I, Khera E, Thurber GM. Quantitative pharmacology in antibody-drug conjugate development: armed antibodies or targeted small molecules? Oncoscience. 5: 161-163. PMID 30035177 DOI: 10.18632/oncoscience.435  0.507
2018 Cilliers C, Thurber GM. "Standing by" for Bystander Effects: Dual-Isotope Imaging of Antibody-Drug Conjugate and Payload Distribution. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 59: 1459-1460. PMID 30002110 DOI: 10.2967/jnumed.118.213389  0.398
2018 Khera E, Cilliers C, Bhatnagar S, Thurber GM. Computational transport analysis of antibody-drug conjugate bystander effects and payload tumoral distribution: implications for therapy Molecular Systems Design & Engineering. 3: 73-88. DOI: 10.1039/C7ME00093F  0.433
2017 Cilliers C, Menezes B, Nessler I, Linderman J, Thurber G. Improved Tumor Penetration and Single-Cell Targeting of Antibody Drug Conjugates Increases Anticancer Efficacy and Host Survival. Cancer Research. PMID 29217763 DOI: 10.1158/0008-5472.CAN-17-1638  0.501
2017 Cilliers C, Nessler I, Christodolu N, Thurber GM. Tracking Antibody Distribution with Near-Infrared Fluorescent Dyes: Impact of Dye Structure and Degree of Labeling on Plasma Clearance. Molecular Pharmaceutics. 14: 1623-1633. PMID 28294622 DOI: 10.1021/acs.molpharmaceut.6b01091  0.507
2016 Cilliers C, Guo H, Liao J, Christodolu N, Thurber GM. Multiscale Modeling of Antibody-Drug Conjugates: Connecting Tissue and Cellular Distribution to Whole Animal Pharmacokinetics and Potential Implications for Efficacy. The Aaps Journal. PMID 27287046 DOI: 10.1208/s12248-016-9940-z  0.573
2014 Bhatnagar S, Deschenes E, Liao J, Cilliers C, Thurber GM. Multichannel imaging to quantify four classes of pharmacokinetic distribution in tumors. Journal of Pharmaceutical Sciences. 103: 3276-86. PMID 25048378 DOI: 10.1002/jps.24086  0.433
2014 Thurber GM, Reiner T, Yang KS, Kohler RH, Weissleder R. Effect of small-molecule modification on single-cell pharmacokinetics of PARP inhibitors. Molecular Cancer Therapeutics. 13: 986-95. PMID 24552776 DOI: 10.1158/1535-7163.Mct-13-0801  0.333
2012 Thurber GM, Wittrup KD. A mechanistic compartmental model for total antibody uptake in tumors. Journal of Theoretical Biology. 314: 57-68. PMID 22974563 DOI: 10.1016/J.Jtbi.2012.08.034  0.702
2012 Wittrup KD, Thurber GM, Schmidt MM, Rhoden JJ. Practical theoretic guidance for the design of tumor-targeting agents. Methods in Enzymology. 503: 255-68. PMID 22230572 DOI: 10.1016/B978-0-12-396962-0.00010-0  0.625
2011 Thurber GM, Weissleder R. A systems approach for tumor pharmacokinetics. Plos One. 6: e24696. PMID 21935441 DOI: 10.1371/Journal.Pone.0024696  0.429
2011 Thurber GM, Figueiredo JL, Weissleder R. Detection limits of intraoperative near infrared imaging for tumor resection. Journal of Surgical Oncology. 102: 758-64. PMID 20872807 DOI: 10.1002/Jso.21735  0.355
2011 Thurber GM, Weissleder R. Quantitating antibody uptake in vivo: conditional dependence on antigen expression levels. Molecular Imaging and Biology. 13: 623-32. PMID 20809210 DOI: 10.1007/S11307-010-0397-7  0.534
2008 Thurber GM, Schmidt MM, Wittrup KD. Antibody tumor penetration: transport opposed by systemic and antigen-mediated clearance. Advanced Drug Delivery Reviews. 60: 1421-34. PMID 18541331 DOI: 10.1016/J.Addr.2008.04.012  0.679
2008 Thurber GM, Wittrup KD. Quantitative spatiotemporal analysis of antibody fragment diffusion and endocytic consumption in tumor spheroids. Cancer Research. 68: 3334-41. PMID 18451160 DOI: 10.1158/0008-5472.Can-07-3018  0.703
2008 Schmidt MM, Thurber GM, Wittrup KD. Kinetics of anti-carcinoembryonic antigen antibody internalization: effects of affinity, bivalency, and stability. Cancer Immunology, Immunotherapy : Cii. 57: 1879-90. PMID 18408925 DOI: 10.1007/S00262-008-0518-1  0.658
2008 Thurber GM, Schmidt MM, Wittrup KD. Factors determining antibody distribution in tumors. Trends in Pharmacological Sciences. 29: 57-61. PMID 18179828 DOI: 10.1016/J.Tips.2007.11.004  0.691
2007 Thurber GM, Zajic SC, Wittrup KD. Theoretic criteria for antibody penetration into solid tumors and micrometastases. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 48: 995-9. PMID 17504872 DOI: 10.2967/Jnumed.106.037069  0.674
Show low-probability matches.