| Year |
Citation |
Score |
| 2022 |
Aublette MC, Harrison TA, Thorpe EJ, Gadd MS. Selective Wee1 degradation by PROTAC degraders recruiting VHL and CRBN E3 ubiquitin ligases. Bioorganic & Medicinal Chemistry Letters. 64: 128636. PMID 35231578 DOI: 10.1016/j.bmcl.2022.128636 |
0.301 |
|
| 2019 |
Testa A, Lucas X, Castro GV, Chan KH, Wright JE, Runcie AC, Gadd MS, Harrison WTA, Ko EJ, Fletcher D, Ciulli A. Correction to "3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation". Journal of the American Chemical Society. PMID 31017404 DOI: 10.1021/jacs.9b03833 |
0.674 |
|
| 2018 |
Testa A, Lucas X, Castro G, Chan KH, Wright J, Runcie A, Gadd M, Harrison WTA, Ko EJ, Fletcher D, Ciulli A. 3-Fluoro-4-hydroxyprolines: Synthesis, conformational analysis and stereoselective recognition by the VHL E3 ubiquitin ligase for targeted protein degradation. Journal of the American Chemical Society. PMID 29949369 DOI: 10.1021/Jacs.8B05807 |
0.656 |
|
| 2017 |
Soares P, Gadd MS, Frost J, Galdeano C, Ellis LCJ, Epemolu O, Rocha S, Read KD, Ciulli A. Group-based optimization of potent and cell-active inhibitors of the von Hippel-Lindau (VHL) E3 ubiquitin ligase: structure-activity relationships leading to the chemical probe (2S,4R)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298). Journal of Medicinal Chemistry. PMID 28853884 DOI: 10.1021/Acs.Jmedchem.7B00675 |
0.72 |
|
| 2017 |
Cardote TAF, Gadd MS, Ciulli A. Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex Structure. 25: 901-911. PMID 28591624 DOI: 10.1016/J.Str.2017.04.009 |
0.704 |
|
| 2017 |
Gadd MS, Testa A, Lucas X, Chan KH, Chen W, Lamont DJ, Zengerle M, Ciulli A. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nature Chemical Biology. PMID 28288108 DOI: 10.1038/Nchembio.2329 |
0.726 |
|
| 2016 |
Frost J, Galdeano C, Soares P, Gadd MS, Grzes KM, Ellis L, Epemolu O, Shimamura S, Bantscheff M, Grandi P, Read KD, Cantrell DA, Rocha S, Ciulli A. Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition. Nature Communications. 7: 13312. PMID 27811928 DOI: 10.1038/Ncomms13312 |
0.694 |
|
| 2015 |
Gadd MS, Bulatov E, Ciulli A. Serendipitous SAD Solution for DMSO-Soaked SOCS2-ElonginC-ElonginB Crystals Using Covalently Incorporated Dimethylarsenic: Insights into Substrate Receptor Conformational Flexibility in Cullin RING Ligases. Plos One. 10: e0131218. PMID 26121586 DOI: 10.1371/Journal.Pone.0131218 |
0.685 |
|
| 2014 |
Galdeano C, Gadd MS, Soares P, Scaffidi S, Van Molle I, Birced I, Hewitt S, Dias DM, Ciulli A. Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von Hippel-Lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities. Journal of Medicinal Chemistry. 57: 8657-63. PMID 25166285 DOI: 10.1021/Jm5011258 |
0.72 |
|
| 2012 |
Bhati M, Lee C, Gadd MS, Jeffries CM, Kwan A, Whitten AE, Trewhella J, Mackay JP, Matthews JM. Solution structure of the LIM-homeodomain transcription factor complex Lhx3/Ldb1 and the effects of a pituitary mutation on key Lhx3 interactions. Plos One. 7: e40719. PMID 22848397 DOI: 10.1371/Journal.Pone.0040719 |
0.313 |
|
| 2011 |
Gadd MS, Bhati M, Jeffries CM, Langley DB, Trewhella J, Guss JM, Matthews JM. Structural basis for partial redundancy in a class of transcription factors, the LIM homeodomain proteins, in neural cell type specification. The Journal of Biological Chemistry. 286: 42971-80. PMID 22025611 DOI: 10.1074/Jbc.M111.248559 |
0.31 |
|
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