Laura M. Bohn, Ph.D. - Publications

Affiliations: 
2003-2008 The Ohio State University College of Medicine 
 2009- Molecular Therapeutics & Neuroscience Scripps Research Institute Florida 
Area:
Pharmacology, Neuropharmacology, Neuroscience
Website:
http://www.scripps.edu/research/faculty/bohn

88 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Hua T, Li X, Wu L, Iliopoulos-Tsoutsouvas C, Wang Y, Wu M, Shen L, Johnston CA, Nikas SP, Song F, Song X, Yuan S, Sun Q, Wu Y, Jiang S, ... ... Bohn LM, et al. Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-G Complex Structures. Cell. PMID 32004463 DOI: 10.1016/j.cell.2020.01.008  0.48
2019 Laprairie RB, Vemuri K, Stahl EL, Korde A, Ho JH, Grim TW, Hua T, Wu Y, Stevens RC, Liu ZJ, Makriyannis A, Bohn LM. Probing the CB1 cannabinoid receptor binding pocket with AM6538, a high-affinity irreversible antagonist. Molecular Pharmacology. PMID 31515283 DOI: 10.1124/mol.119.116483  0.48
2019 Grim TW, Schmid CL, Stahl EL, Pantouli F, Ho JH, Acevedo-Canabal A, Kennedy NM, Cameron MD, Bannister TD, Bohn LM. A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 31443104 DOI: 10.1038/s41386-019-0491-8  1
2019 Stahl EL, Ehlert FJ, Bohn LM. Quantitating Ligand Bias Using the Competitive Model of Ligand Activity. Methods in Molecular Biology (Clifton, N.J.). 1957: 235-247. PMID 30919358 DOI: 10.1007/978-1-4939-9158-7_15  0.48
2018 Kennedy NM, Schmid CL, Ross NC, Lovell KM, Yue Z, Chen YT, Cameron MD, Bohn LM, Bannister TD. Optimization of a Series of Mu Opioid Receptor (MOR) Agonists with High G Protein Signaling Bias. Journal of Medicinal Chemistry. PMID 30199635 DOI: 10.1021/acs.jmedchem.8b01136  1
2018 Grim TW, Park SJ, Schmid CL, Laprairie RB, Cameron M, Bohn LM. The effect of quinine in two bottle choice procedures in C57BL6 mice: Opioid preference, somatic withdrawal, and pharmacokinetic outcomes. Drug and Alcohol Dependence. 191: 195-202. PMID 30138791 DOI: 10.1016/j.drugalcdep.2018.05.034  1
2018 Donthamsetti P, Gallo EF, Buck DC, Stahl EL, Zhu Y, Lane JR, Bohn LM, Neve KA, Kellendonk C, Javitch JA. Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation. Molecular Psychiatry. PMID 30120413 DOI: 10.1038/s41380-018-0212-4  0.48
2017 Roach JJ, Sasano Y, Schmid CL, Zaidi S, Katritch V, Stevens RC, Bohn LM, Shenvi RA. Dynamic Strategic Bond Analysis Yields a Ten-Step Synthesis of 20-nor-Salvinorin A, a Potent κ-OR Agonist. Acs Central Science. 3: 1329-1336. PMID 29296674 DOI: 10.1021/acscentsci.7b00488  1
2017 Schmid CL, Kennedy NM, Ross NC, Lovell KM, Yue Z, Morgenweck J, Cameron MD, Bannister TD, Bohn LM. Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics. Cell. 171: 1165-1175.e13. PMID 29149605 DOI: 10.1016/j.cell.2017.10.035  1
2017 Laprairie RB, Stahl EL, Bohn LM. Approaches to Assess Biased Signaling at the CB1R Receptor. Methods in Enzymology. 593: 259-279. PMID 28750807 DOI: 10.1016/bs.mie.2017.06.031  0.48
2017 Bohn LM, Aubé J. Seeking (and Finding) Biased Ligands of the Kappa Opioid Receptor. Acs Medicinal Chemistry Letters. 8: 694-700. PMID 28740600 DOI: 10.1021/acsmedchemlett.7b00224  0.48
2017 Lovell KM, Frankowski KJ, Stahl EL, Slauson SR, Yoo E, Prisinzano TE, Aubé J, Bohn LM. Correction to "Structure-Activity Relationship Studies of Functionally Selective Kappa Opioid Receptor Agonists that Modulate ERK 1/2 Phosphorylation While Preserving G Protein Over βArrestin2 Signaling Bias". Acs Chemical Neuroscience. PMID 28541028 DOI: 10.1021/acschemneuro.7b00157  0.48
2017 Mason JW, Schmid CL, Bohn LM, Roush WR. Stolonidiol: Synthesis, Target Identification, and Mechanism for Choline Acetyltransferase Activation. Journal of the American Chemical Society. PMID 28414442 DOI: 10.1021/jacs.7b01083  1
2016 Brust TF, Morgenweck J, Kim SA, Rose JH, Locke JL, Schmid CL, Zhou L, Stahl EL, Cameron MD, Scarry SM, Aubé J, Jones SR, Martin TJ, Bohn LM. Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria. Science Signaling. 9: ra117. PMID 27899527 DOI: 10.1126/scisignal.aai8441  1
2016 Hua T, Vemuri K, Pu M, Qu L, Han GW, Wu Y, Zhao S, Shui W, Li S, Korde A, Laprairie RB, Stahl EL, Ho JH, Zvonok N, Zhou H, ... ... Bohn LM, et al. Crystal Structure of the Human Cannabinoid Receptor CB1. Cell. 167: 750-762.e14. PMID 27768894 DOI: 10.1016/j.cell.2016.10.004  0.48
2016 Scarry SM, Lovell KM, Frankowski KJ, Bohn LM, Aubé J. Synthesis of Kappa Opioid Antagonists Based On Pyrrolo[1,2-alpha]quinoxalinones Using an N-Arylation/Condensation/Oxidation Reaction Sequence. The Journal of Organic Chemistry. PMID 27399050 DOI: 10.1021/acs.joc.6b01350  0.48
2016 Reis-Rodrigues P, Kaul TK, Ho JH, Lucanic M, Burkewitz K, Mair WB, Held JM, Bohn LM, Gill MS. Synthetic Ligands of Cannabinoid Receptors Affect Dauer Formation in the Nematode Caenorhabditis elegans. G3 (Bethesda, Md.). PMID 27172180 DOI: 10.1534/g3.116.026997  1
2015 Rankovic Z, Brust TF, Bohn LM. Biased agonism: An emerging paradigm in GPCR drug discovery. Bioorganic & Medicinal Chemistry Letters. PMID 26707396 DOI: 10.1016/j.bmcl.2015.12.024  1
2015 Green JA, Schmid CL, Bley E, Monsma PC, Brown A, Bohn LM, Mykytyn K. Recruitment of β-arrestin into Neuronal Cilia Modulates Somatostatin Receptor Subtype 3 Ciliary Localization. Molecular and Cellular Biology. PMID 26503786 DOI: 10.1128/MCB.00765-15  1
2015 You IJ, Wright SR, Garcia-Garcia AL, Tapper AR, Gardner PD, Koob GF, Leonardo ED, Bohn LM, Wee S. 5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26324408 DOI: 10.1038/npp.2015.268  1
2015 Morgenweck J, Frankowski KJ, Prisinzano TE, Aubé J, Bohn LM. Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus. Neuropharmacology. PMID 26318102 DOI: 10.1016/j.neuropharm.2015.08.027  1
2015 Bohn LM, Zhou L, Ho JH. Approaches to Assess Functional Selectivity in GPCRs: Evaluating G Protein Signaling in an Endogenous Environment. Methods in Molecular Biology (Clifton, N.J.). 1335: 177-89. PMID 26260601 DOI: 10.1007/978-1-4939-2914-6_12  1
2015 Bohn LM, Lohse MJ, Nitabach M, Taghert PH, Smit MJ. Exploring the Biology of GPCRs from In Vitro to In Vivo. Molecular Pharmacology. PMID 26162863 DOI: 10.1124/mol.115.100750  0.4
2015 Zhou L, Stahl EL, Lovell KM, Frankowski KJ, Prisinzano TE, Aubé J, Bohn LM. Characterization of kappa opioid receptor mediated, dynorphin-stimulated [(35)S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting. Neuropharmacology. PMID 26160155 DOI: 10.1016/j.neuropharm.2015.07.001  1
2015 Luttrell LM, Maudsley S, Bohn LM. Fulfilling the Promise of 'Biased' GPCR Agonism. Molecular Pharmacology. PMID 26134495 DOI: 10.1124/mol.115.099630  0.4
2015 Janero DR, Yaddanapudi S, Zvonok N, Subramanian KV, Shukla VG, Stahl E, Zhou L, Hurst D, Wager-Miller J, Bohn LM, Reggio PH, Mackie K, Makriyannis A. Molecular-Interaction and Signaling Profiles of AM3677, a Novel Covalent Agonist Selective for the Cannabinoid 1 Receptor. Acs Chemical Neuroscience. PMID 25978068 DOI: 10.1021/acschemneuro.5b00090  1
2015 Lovell KM, Frankowski KJ, Stahl EL, Slauson SR, Yoo E, Prisinzano TE, Aubé J, Bohn LM. Structure-Activity Relationship Studies of Functionally Selective Kappa Opioid Receptor Agonists that Modulate ERK 1/2 Phosphorylation While Preserving G Protein Over βArrestin2 Signaling Bias. Acs Chemical Neuroscience. PMID 25891774 DOI: 10.1021/acschemneuro.5b00092  1
2015 Stahl EL, Zhou L, Ehlert FJ, Bohn LM. A novel method for analyzing extremely biased agonism at G protein-coupled receptors. Molecular Pharmacology. 87: 866-77. PMID 25680753 DOI: 10.1124/mol.114.096503  0.4
2015 Frankowski KJ, Slauson SR, Lovell KM, Phillips AM, Streicher JM, Zhou L, Whipple DA, Schoenen FJ, Prisinzano TE, Bohn LM, Aubé J. Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif. Bioorganic & Medicinal Chemistry. 23: 3948-56. PMID 25593096 DOI: 10.1016/j.bmc.2014.12.033  1
2014 Zhou L, Bohn LM. Functional selectivity of GPCR signaling in animals. Current Opinion in Cell Biology. 27: 102-8. PMID 24680435 DOI: 10.1016/j.ceb.2013.11.010  1
2014 Schmid CL, Streicher JM, Meltzer HY, Bohn LM. Clozapine acts as an agonist at serotonin 2A receptors to counter MK-801-induced behaviors through a βarrestin2-independent activation of Akt. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 1902-13. PMID 24531562 DOI: 10.1038/npp.2014.38  1
2014 Raehal KM, Bohn LM. β-arrestins: regulatory role and therapeutic potential in opioid and cannabinoid receptor-mediated analgesia. Handbook of Experimental Pharmacology. 219: 427-43. PMID 24292843 DOI: 10.1007/978-3-642-41199-1_22  1
2013 Zhou L, Lovell KM, Frankowski KJ, Slauson SR, Phillips AM, Streicher JM, Stahl E, Schmid CL, Hodder P, Madoux F, Cameron MD, Prisinzano TE, Aubé J, Bohn LM. Development of functionally selective, small molecule agonists at kappa opioid receptors. The Journal of Biological Chemistry. 288: 36703-16. PMID 24187130 DOI: 10.1074/jbc.M113.504381  1
2013 Schmid CL, Streicher JM, Groer CE, Munro TA, Zhou L, Bohn LM. Functional selectivity of 6'-guanidinonaltrindole (6'-GNTI) at κ-opioid receptors in striatal neurons. The Journal of Biological Chemistry. 288: 22387-98. PMID 23775075 DOI: 10.1074/jbc.M113.476234  1
2012 Zhou H, Chisari M, Raehal KM, Kaltenbronn KM, Bohn LM, Mennerick SJ, Blumer KJ. GIRK channel modulation by assembly with allosterically regulated RGS proteins. Proceedings of the National Academy of Sciences of the United States of America. 109: 19977-82. PMID 23169654 DOI: 10.1073/pnas.1214337109  1
2012 Frankowski KJ, Hedrick MP, Gosalia P, Li K, Shi S, Whipple D, Ghosh P, Prisinzano TE, Schoenen FJ, Su Y, Vasile S, Sergienko E, Gray W, Hariharan S, Milan L, ... ... Bohn LM, et al. Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy. Acs Chemical Neuroscience. 3: 221-236. PMID 22737280 DOI: 10.1021/cn200128x  1
2012 Nguyen PT, Schmid CL, Raehal KM, Selley DE, Bohn LM, Sim-Selley LJ. β-arrestin2 regulates cannabinoid CB1 receptor signaling and adaptation in a central nervous system region-dependent manner. Biological Psychiatry. 71: 714-24. PMID 22264443 DOI: 10.1016/j.biopsych.2011.11.027  1
2012 Béguin C, Potuzak J, Xu W, Liu-Chen LY, Streicher JM, Groer CE, Bohn LM, Carlezon WA, Cohen BM. Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues. Bioorganic & Medicinal Chemistry Letters. 22: 1023-6. PMID 22204910 DOI: 10.1016/j.bmcl.2011.11.128  1
2012 Lamb K, Tidgewell K, Simpson DS, Bohn LM, Prisinzano TE. Antinociceptive effects of herkinorin, a MOP receptor agonist derived from salvinorin A in the formalin test in rats: new concepts in mu opioid receptor pharmacology: from a symposium on new concepts in mu-opioid pharmacology. Drug and Alcohol Dependence. 121: 181-8. PMID 22119134 DOI: 10.1016/j.drugalcdep.2011.10.026  1
2011 Raehal KM, Schmid CL, Groer CE, Bohn LM. Functional selectivity at the μ-opioid receptor: implications for understanding opioid analgesia and tolerance. Pharmacological Reviews. 63: 1001-19. PMID 21873412 DOI: 10.1124/pr.111.004598  1
2011 Groer CE, Schmid CL, Jaeger AM, Bohn LM. Agonist-directed interactions with specific beta-arrestins determine mu-opioid receptor trafficking, ubiquitination, and dephosphorylation. The Journal of Biological Chemistry. 286: 31731-41. PMID 21757712 DOI: 10.1074/jbc.M111.248310  1
2011 Tarselli MA, Raehal KM, Brasher AK, Streicher JM, Groer CE, Cameron MD, Bohn LM, Micalizio GC. Synthesis of conolidine, a potent non-opioid analgesic for tonic and persistent pain. Nature Chemistry. 3: 449-53. PMID 21602859 DOI: 10.1038/nchem.1050  1
2011 Sun X, Wang X, Wang GD, Xia Y, Liu S, Qu M, Needleman BJ, Mikami DJ, Melvin WS, Bohn LM, Ueno R, Wood JD. Lubiprostone reverses the inhibitory action of morphine on mucosal secretion in human small intestine. Digestive Diseases and Sciences. 56: 330-8. PMID 21181441 DOI: 10.1007/s10620-010-1515-8  1
2011 Raehal KM, Bohn LM. The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics. Neuropharmacology. 60: 58-65. PMID 20713067 DOI: 10.1016/j.neuropharm.2010.08.003  1
2011 Bohn LM, McDonald PH. Detecting the Role of arrestins in G protein-coupled receptor regulation Neuromethods. 60: 347-358. DOI: 10.1007/978-1-61779-179-6_17  1
2010 Bohn LM, McDonald PH. Seeking Ligand Bias: Assessing GPCR Coupling to Beta-Arrestins for Drug Discovery. Drug Discovery Today. Technologies. 7: e37-e42. PMID 21218149 DOI: 10.1016/j.ddtec.2010.06.005  1
2010 Schmid CL, Bohn LM. Serotonin, but not N-methyltryptamines, activates the serotonin 2A receptor via a ß-arrestin2/Src/Akt signaling complex in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13513-24. PMID 20926677 DOI: 10.1523/JNEUROSCI.1665-10.2010  1
2010 Bohn LM, Schmid CL. Serotonin receptor signaling and regulation via β-arrestins. Critical Reviews in Biochemistry and Molecular Biology. 45: 555-66. PMID 20925600 DOI: 10.3109/10409238.2010.516741  1
2010 Fei G, Raehal K, Liu S, Qu MH, Sun X, Wang GD, Wang XY, Xia Y, Schmid CL, Bohn LM, Wood JD. Lubiprostone reverses the inhibitory action of morphine on intestinal secretion in guinea pig and mouse. The Journal of Pharmacology and Experimental Therapeutics. 334: 333-40. PMID 20406855 DOI: 10.1124/jpet.110.166116  1
2009 Zhang L, Nothacker HP, Wang Z, Bohn LM, Civelli O. Pharmacological characterization of a selective agonist for bombesin receptor subtype-3. Biochemical and Biophysical Research Communications. 387: 283-8. PMID 19580790 DOI: 10.1016/j.bbrc.2009.07.006  1
2009 Raehal KM, Schmid CL, Medvedev IO, Gainetdinov RR, Premont RT, Bohn LM. Morphine-induced physiological and behavioral responses in mice lacking G protein-coupled receptor kinase 6. Drug and Alcohol Dependence. 104: 187-96. PMID 19497686 DOI: 10.1016/j.drugalcdep.2009.04.011  1
2009 Fei G, Wang YZ, Liu S, Hu HZ, Wang GD, Qu MH, Wang XY, Xia Y, Sun X, Bohn LM, Cooke HJ, Wood JD. Stimulation of mucosal secretion by lubiprostone (SPI-0211) in guinea pig small intestine and colon. American Journal of Physiology. Gastrointestinal and Liver Physiology. 296: G823-32. PMID 19179625 DOI: 10.1152/ajpgi.90447.2008  1
2009 Schmid CL, Bohn LM. Physiological and pharmacological implications of beta-arrestin regulation. Pharmacology & Therapeutics. 121: 285-93. PMID 19100766 DOI: 10.1016/j.pharmthera.2008.11.005  1
2008 McLennan GP, Kiss A, Miyatake M, Belcheva MM, Chambers KT, Pozek JJ, Mohabbat Y, Moyer RA, Bohn LM, Coscia CJ. Kappa opioids promote the proliferation of astrocytes via Gbetagamma and beta-arrestin 2-dependent MAPK-mediated pathways. Journal of Neurochemistry. 107: 1753-65. PMID 19014370 DOI: 10.1111/j.1471-4159.2008.05745.x  1
2008 Tidgewell K, Groer CE, Harding WW, Lozama A, Schmidt M, Marquam A, Hiemstra J, Partilla JS, Dersch CM, Rothman RB, Bohn LM, Prisinzano TE. Herkinorin analogues with differential beta-arrestin-2 interactions. Journal of Medicinal Chemistry. 51: 2421-31. PMID 18380425 DOI: 10.1021/jm701162g  0.64
2008 Gupta A, Rozenfeld R, Gomes I, Raehal KM, Décaillot FM, Bohn LM, Devi LA. Post-activation-mediated changes in opioid receptors detected by N-terminal antibodies. The Journal of Biological Chemistry. 283: 10735-44. PMID 18256033 DOI: 10.1074/jbc.M709454200  1
2008 Schmid CL, Raehal KM, Bohn LM. Agonist-directed signaling of the serotonin 2A receptor depends on beta-arrestin-2 interactions in vivo. Proceedings of the National Academy of Sciences of the United States of America. 105: 1079-84. PMID 18195357 DOI: 10.1073/pnas.0708862105  1
2007 Bohn LM. Constitutive trafficking--more than just running in circles? Molecular Pharmacology. 71: 957-8. PMID 17251327 DOI: 10.1124/mol.107.034223  1
2007 Xu H, Partilla JS, Wang X, Rutherford JM, Tidgewell K, Prisinzano TE, Bohn LM, Rothman RB. A comparison of noninternalizing (herkinorin) and internalizing (DAMGO) mu-opioid agonists on cellular markers related to opioid tolerance and dependence. Synapse (New York, N.Y.). 61: 166-75. PMID 17152090 DOI: 10.1002/syn.20356  1
2007 Groer CE, Tidgewell K, Moyer RA, Harding WW, Rothman RB, Prisinzano TE, Bohn LM. An opioid agonist that does not induce mu-opioid receptor--arrestin interactions or receptor internalization. Molecular Pharmacology. 71: 549-57. PMID 17090705 DOI: 10.1124/mol.106.028258  1
2006 Sadée W, Bohn L. How specific are "target-specific" drugs? Celecoxib as a case in point. Molecular Interventions. 6: 196-8. PMID 16960141 DOI: 10.1124/mi.6.4.5  1
2006 Bohn LM, Raehal KM. Opioid receptor signaling: relevance for gastrointestinal therapy. Current Opinion in Pharmacology. 6: 559-63. PMID 16935560 DOI: 10.1016/j.coph.2006.06.007  1
2005 Raehal KM, Bohn LM. Mu opioid receptor regulation and opiate responsiveness. The Aaps Journal. 7: E587-91. PMID 16353937 DOI: 10.1208/aapsj070360  1
2005 Raehal KM, Walker JK, Bohn LM. Morphine side effects in beta-arrestin 2 knockout mice. The Journal of Pharmacology and Experimental Therapeutics. 314: 1195-201. PMID 15917400 DOI: 10.1124/jpet.105.087254  1
2005 Wang D, Sun X, Bohn LM, Sadée W. Opioid receptor homo- and heterodimerization in living cells by quantitative bioluminescence resonance energy transfer. Molecular Pharmacology. 67: 2173-84. PMID 15778451 DOI: 10.1124/mol.104.010272  1
2005 Medvedev IO, Gainetdinov RR, Sotnikova TD, Bohn LM, Caron MG, Dykstra LA. Characterization of conditioned place preference to cocaine in congenic dopamine transporter knockout female mice. Psychopharmacology. 180: 408-13. PMID 15719221 DOI: 10.1007/s00213-005-2173-y  1
2004 Gainetdinov RR, Premont RT, Bohn LM, Lefkowitz RJ, Caron MG. Desensitization of G protein-coupled receptors and neuronal functions. Annual Review of Neuroscience. 27: 107-44. PMID 15217328 DOI: 10.1146/annurev.neuro.27.070203.144206  1
2004 Bohn LM, Dykstra LA, Lefkowitz RJ, Caron MG, Barak LS. Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery. Molecular Pharmacology. 66: 106-12. PMID 15213301 DOI: 10.1124/mol.66.1.106  1
2004 Bohn LM, Gainetdinov RR, Caron MG. G protein-coupled receptor kinase/beta-arrestin systems and drugs of abuse: psychostimulant and opiate studies in knockout mice. Neuromolecular Medicine. 5: 41-50. PMID 15001811 DOI: 10.1385/NMM:5:1:041  1
2004 Johnson EC, Bohn LM, Taghert PH. Drosophila CG8422 encodes a functional diuretic hormone receptor. The Journal of Experimental Biology. 207: 743-8. PMID 14747406 DOI: 10.1242/jeb.00818  1
2003 Bohn LM, Gainetdinov RR, Sotnikova TD, Medvedev IO, Lefkowitz RJ, Dykstra LA, Caron MG. Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 10265-73. PMID 14614085  1
2003 Johnson EC, Bohn LM, Barak LS, Birse RT, Nässel DR, Caron MG, Taghert PH. Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions. The Journal of Biological Chemistry. 278: 52172-8. PMID 14555656 DOI: 10.1074/jbc.M306756200  1
2003 Cyr M, Beaulieu JM, Laakso A, Sotnikova TD, Yao WD, Bohn LM, Gainetdinov RR, Caron MG. Sustained elevation of extracellular dopamine causes motor dysfunction and selective degeneration of striatal GABAergic neurons. Proceedings of the National Academy of Sciences of the United States of America. 100: 11035-40. PMID 12958210 DOI: 10.1073/pnas.1831768100  1
2003 Gainetdinov RR, Bohn LM, Sotnikova TD, Cyr M, Laakso A, Macrae AD, Torres GE, Kim KM, Lefkowitz RJ, Caron MG, Premont RT. Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice. Neuron. 38: 291-303. PMID 12718862 DOI: 10.1016/S0896-6273(03)00192-2  1
2002 Bohn LM, Lefkowitz RJ, Caron MG. Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 10494-500. PMID 12451149  1
2002 Wilbanks AM, Laporte SA, Bohn LM, Barak LS, Caron MG. Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors. Biochemistry. 41: 11981-9. PMID 12356298 DOI: 10.1021/bi020275m  1
2001 Gainetdinov RR, Mohn AR, Bohn LM, Caron MG. Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter. Proceedings of the National Academy of Sciences of the United States of America. 98: 11047-54. PMID 11572967 DOI: 10.1073/pnas.191353298  1
2000 Bohn LM, Gainetdinov RR, Lin FT, Lefkowitz RJ, Caron MG. Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. Nature. 408: 720-3. PMID 11130073 DOI: 10.1038/35047086  1
2000 Bohn LM, Xu F, Gainetdinov RR, Caron MG. Potentiated opioid analgesia in norepinephrine transporter knock-out mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 9040-5. PMID 11124980  1
2000 Xu F, Gainetdinov RR, Wetsel WC, Jones SR, Bohn LM, Miller GW, Wang YM, Caron MG. Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. Nature Neuroscience. 3: 465-71. PMID 10769386 DOI: 10.1038/74839  1
2000 Bohn LM, Belcheva MM, Coscia CJ. Mu-opioid agonist inhibition of kappa-opioid receptor-stimulated extracellular signal-regulated kinase phosphorylation is dynamin-dependent in C6 glioma cells. Journal of Neurochemistry. 74: 574-81. PMID 10646508 DOI: 10.1046/j.1471-4159.2000.740574.x  1
2000 Bohn LM, Belcheva MM, Coscia CJ. Mitogenic signaling via endogenous kappa-opioid receptors in C6 glioma cells: evidence for the involvement of protein kinase C and the mitogen-activated protein kinase signaling cascade. Journal of Neurochemistry. 74: 564-73. PMID 10646507 DOI: 10.1046/j.1471-4159.2000.740564.x  1
1999 Gainetdinov RR, Bohn LM, Walker JK, Laporte SA, Macrae AD, Caron MG, Lefkowitz RJ, Premont RT. Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice. Neuron. 24: 1029-36. PMID 10624964  1
1999 Bohn LM, Lefkowitz RJ, Gainetdinov RR, Peppel K, Caron MG, Lin FT. Enhanced morphine analgesia in mice lacking beta-arrestin 2. Science (New York, N.Y.). 286: 2495-8. PMID 10617462 DOI: 10.1126/science.286.5449.2495  1
1999 Ignatova EG, Belcheva MM, Bohn LM, Neuman MC, Coscia CJ. Requirement of receptor internalization for opioid stimulation of mitogen-activated protein kinase: biochemical and immunofluorescence confocal microscopic evidence. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 56-63. PMID 9870938  1
1998 Pan EC, Bohn LM, Belcheva MM, Thomas GE, Manepalli AN, Mamone JY, Johnson FE, Coscia CJ. Kappa-opioid receptor binding varies inversely with tumor grade in human gliomas. Cancer. 83: 2561-6. PMID 9874464 DOI: 10.1002/(SICI)1097-0142(19981215)83:12<2561::AID-CNCR23>3.0.CO;2-H  1
1998 Belcheva MM, Bohn LM, Ho MT, Johnson FE, Yanai J, Barron S, Coscia CJ. Brain opioid receptor adaptation and expression after prenatal exposure to buprenorphine. Brain Research. Developmental Brain Research. 111: 35-42. PMID 9804882 DOI: 10.1016/S0165-3806(98)00117-5  1
1998 Bohn LM, Belcheva MM, Coscia CJ. Evidence for kappa- and mu-opioid receptor expression in C6 glioma cells. Journal of Neurochemistry. 70: 1819-25. PMID 9572265  1
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