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Brian A. Joughin - Publications

Affiliations: 
Massachusetts Institute of Technology, Cambridge, MA, United States 
Area:
computational biology, cancer biology, systems biology
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32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 van de Kooij B, van der Wal FJ, Rother MB, Creixell P, Stout M, Wiegant W, Joughin BA, Vornberger J, van Vugt MATM, Altmeyer M, Yaffe MB, van Attikum H. The Fanconi anemia core complex promotes CtIP-dependent end-resection to drive homologous recombination at DNA double-strand breaks. Biorxiv : the Preprint Server For Biology. PMID 37732274 DOI: 10.1101/2023.09.05.556391  0.449
2023 Green BL, Gamble LA, Diggs LP, Nousome D, Patterson JC, Joughin BA, Gasmi B, Lux SC, Samaranayake SG, Miettinen M, Quezado M, Hernandez JM, Yaffe MB, Davis JL. Early immune changes support signet ring cell dormancy in CDH1-driven hereditary diffuse gastric carcinogenesis. Molecular Cancer Research : McR. PMID 37707375 DOI: 10.1158/1541-7786.MCR-23-0122  0.448
2023 Netterfield TS, Ostheimer GJ, Tentner AR, Joughin BA, Dakoyannis AM, Sharma CD, Sorger PK, Janes KA, Lauffenburger DA, Yaffe MB. Biphasic JNK-Erk signaling separates the induction and maintenance of cell senescence after DNA damage induced by topoisomerase II inhibition. Cell Systems. 14: 582-604.e10. PMID 37473730 DOI: 10.1016/j.cels.2023.06.005  0.68
2022 Goretti Riça I, Joughin BA, Teke ME, Emmons TR, Griffith AM, Cahill LA, Banner-Goodspeed VM, Robson SC, Hernandez JM, Segal BH, Otterbein LE, Hauser CJ, Lederer JA, Yaffe MB. Neutrophil heterogeneity and emergence of a distinct population of CD11b/CD18-activated low-density neutrophils after trauma. The Journal of Trauma and Acute Care Surgery. 94: 187-196. PMID 36694330 DOI: 10.1097/TA.0000000000003823  0.397
2022 Moore HB, Neal MD, Bertolet M, Joughin BA, Yaffe MB, Barrett CD, Bird MA, Tracy RP, Moore EE, Sperry JL, Zuckerbraun BS, Park MS, Cohen MJ, Wisniewski SR, Morrissey JH. Proteomics of Coagulopathy Following Injury Reveals Limitations of Using Laboratory Assessment to Define Trauma-Induced Coagulopathy to Predict Massive Transfusion. Annals of Surgery Open : Perspectives of Surgical History, Education, and Clinical Approaches. 3. PMID 36177090 DOI: 10.1097/as9.0000000000000167  0.422
2021 Sriram G, Milling LE, Chen JK, Kong YW, Joughin BA, Abraham W, Swartwout S, Handly ED, Irvine DJ, Yaffe MB. The injury response to DNA damage in live tumor cells promotes antitumor immunity. Science Signaling. 14: eabc4764. PMID 34665642 DOI: 10.1126/scisignal.abc4764  0.425
2020 Cahill LA, Joughin BA, Kwon WY, Itagaki K, Kirk CH, Shapiro NI, Otterbein LE, Yaffe MB, Lederer JA, Hauser CJ. Multiplexed Plasma Immune Mediator Signatures Can Differentiate Sepsis From NonInfective SIRS: American Surgical Association 2020 Annual Meeting Paper. Annals of Surgery. 272: 604-610. PMID 32932316 DOI: 10.1097/Sla.0000000000004379  0.455
2020 Krismer K, Bird MA, Varmeh S, Handly ED, Gattinger A, Bernwinkler T, Anderson DA, Heinzel A, Joughin BA, Kong YW, Cannell IG, Yaffe MB. Transite: A Computational Motif-Based Analysis Platform That Identifies RNA-Binding Proteins Modulating Changes in Gene Expression. Cell Reports. 32: 108064. PMID 32846122 DOI: 10.1016/J.Celrep.2020.108064  0.501
2020 Stopfer LE, Mesfin JM, Joughin BA, Lauffenburger DA, White FM. Multiplexed relative and absolute quantitative immunopeptidomics reveals MHC I repertoire alterations induced by CDK4/6 inhibition. Nature Communications. 11: 2760. PMID 32488085 DOI: 10.1038/S41467-020-16588-9  0.316
2019 Strasser SD, Ghazi PC, Starchenko A, Boukhali M, Edwards A, Suarez-Lopez L, Lyons J, Changelian PS, Monahan JB, Jacobsen J, Brubaker DK, Joughin BA, Yaffe MB, Haas W, Lauffenburger DA, et al. Substrate-based kinase activity inference identifies MK2 as driver of colitis. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 31617572 DOI: 10.1093/Intbio/Zyz025  0.626
2019 Brubaker DK, Paulo JA, Sheth S, Poulin EJ, Popow O, Joughin BA, Strasser SD, Starchenko A, Gygi SP, Lauffenburger DA, Haigis KM. Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation. Cell Systems. PMID 31521603 DOI: 10.1016/J.Cels.2019.07.006  0.318
2019 Patterson JC, Joughin BA, Prota AE, Mühlethaler T, Jonas OH, Whitman MA, Varmeh S, Chen S, Balk SP, Steinmetz MO, Lauffenburger DA, Yaffe MB. VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells. Cell Systems. PMID 31302152 DOI: 10.1016/J.Cels.2019.05.009  0.528
2019 van de Kooij B, Creixell P, van Vlimmeren A, Joughin B, Miller CJ, Haider N, Simpson CD, Linding R, Stambolic V, Turk BE, Yaffe MB. Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs. Elife. 8. PMID 31124786 DOI: 10.7554/Elife.44635  0.635
2019 Patterson JC, Joughin BA, van de Kooij B, Lim DC, Lauffenburger DA, Yaffe MB. ROS and Oxidative Stress Are Elevated in Mitosis during Asynchronous Cell Cycle Progression and Are Exacerbated by Mitotic Arrest. Cell Systems. PMID 30797774 DOI: 10.1016/J.Cels.2019.01.005  0.5
2019 Rohani N, Hao L, Alexis MS, Joughin BA, Krismer K, Moufarrej MN, Soltis AR, Lauffenburger DA, Yaffe MB, Burge CB, Bhatia SN, Gertler FB. Acidification of tumor at stromal boundaries drives transcriptome alterations associated with aggressive phenotypes. Cancer Research. PMID 30755444 DOI: 10.1158/0008-5472.Can-18-1604  0.487
2019 Kooij Bvd, Creixell P, Vlimmeren Av, Joughin BA, Miller CJ, Haider N, Simpson CD, Linding R, Stambolic V, Turk BE, Yaffe MB. Author response: Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs Elife. DOI: 10.7554/Elife.44635.025  0.505
2018 Randall EC, Emdal KB, Laramy JK, Kim M, Roos A, Calligaris D, Regan MS, Gupta SK, Mladek AC, Carlson BL, Johnson AJ, Lu FK, Xie XS, Joughin BA, Reddy RJ, et al. Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma. Nature Communications. 9: 4904. PMID 30464169 DOI: 10.1038/S41467-018-07334-3  0.313
2018 Amal H, Barak B, Bhat V, Gong G, Joughin BA, Wishnok JS, Feng G, Tannenbaum SR. Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function. Molecular Psychiatry. PMID 29988084 DOI: 10.1038/S41380-018-0113-6  0.325
2018 Jones DS, Jenney AP, Joughin BA, Sorger PK, Lauffenburger DA. Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition. Science Signaling. 11. PMID 29511118 DOI: 10.1126/Scisignal.Aal1601  0.355
2016 Nagel ZD, Kitange GJ, Gupta SK, Joughin BA, Chaim IA, Mazzucato P, Lauffenburger DA, Sarkaria JN, Samson LD. DNA repair capacity in multiple pathways predicts chemoresistance in glioblastoma multiforme. Cancer Research. PMID 27793847 DOI: 10.1158/0008-5472.Can-16-1151  0.331
2015 Hughes SK, Oudin MJ, Tadros J, Neil J, Del Rosario A, Joughin BA, Ritsma L, Wyckoff J, Vasile E, Eddy R, Philippar U, Lussiez A, Condeelis JS, van Rheenen J, White F, et al. PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena. Molecular Biology of the Cell. PMID 26337385 DOI: 10.1091/Mbc.E15-06-0442  0.429
2015 Travers T, Shao H, Joughin BA, Lauffenburger DA, Wells A, Camacho CJ. Tandem phosphorylation within an intrinsically disordered region regulates ACTN4 function. Science Signaling. 8: ra51. PMID 26012634 DOI: 10.1126/Scisignal.Aaa1977  0.474
2015 Meacham CE, Lawton LN, Soto-Feliciano YM, Pritchard JR, Joughin BA, Ehrenberger T, Fenouille N, Zuber J, Williams RT, Young RA, Hemann MT. A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth. Genes & Development. 29: 483-8. PMID 25737277 DOI: 10.1101/Gad.254151.114  0.345
2012 Joughin BA, Liu C, Lauffenburger DA, Hogue CW, Yaffe MB. Protein kinases display minimal interpositional dependence on substrate sequence: potential implications for the evolution of signalling networks. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 367: 2574-83. PMID 22889908 DOI: 10.1098/Rstb.2012.0010  0.631
2011 Grosstessner-Hain K, Hegemann B, Novatchkova M, Rameseder J, Joughin BA, Hudecz O, Roitinger E, Pichler P, Kraut N, Yaffe MB, Peters JM, Mechtler K. Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome. Molecular & Cellular Proteomics : McP. 10: M111.008540. PMID 21857030 DOI: 10.1074/Mcp.M111.008540  0.758
2011 Alexander J, Lim D, Joughin BA, Hegemann B, Hutchins JRA, Ehrenberger T, Ivins F, Sessa F, Hudecz O, Nigg EA, Fry AM, Musacchio A, Stukenberg PT, Mechtler K, Peters JM, et al. Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling Science Signaling. 4. PMID 21712545 DOI: 10.1126/Scisignal.2001796  0.758
2011 Grosstessner-Hain K, Hegemann B, Novatchkova M, Rameseder J, Joughin BA, Hudecz O, Roitinger E, Pichler P, Kraut N, Yaffe MB, Peters JM, Mechtler K. Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome Molecular and Cellular Proteomics. 10. DOI: 10.1074/mcp.M111.008540  0.745
2010 Naegle KM, Gymrek M, Joughin BA, Wagner JP, Welsch RE, Yaffe MB, Lauffenburger DA, White FM. PTMScout, a Web resource for analysis of high throughput post-translational proteomics studies. Molecular & Cellular Proteomics : McP. 9: 2558-70. PMID 20631208 DOI: 10.1074/Mcp.M110.001206  0.533
2009 Joughin BA, Naegle KM, Huang PH, Yaffe MB, Lauffenburger DA, White FM. An integrated comparative phosphoproteomic and bioinformatic approach reveals a novel class of MPM-2 motifs upregulated in EGFRvIII-expressing glioblastoma cells. Molecular Biosystems. 5: 59-67. PMID 19081932 DOI: 10.1039/B815075C  0.606
2005 Joughin BA, Green DF, Tidor B. Action-at-a-distance interactions enhance protein binding affinity. Protein Science : a Publication of the Protein Society. 14: 1363-9. PMID 15802650 DOI: 10.1110/Ps.041283105  0.671
2005 Joughin BA, Tidor B, Yaffe MB. A computational method for the analysis and prediction of protein: Phosphopeptide-binding sites Protein Science. 14: 131-139. PMID 15576564 DOI: 10.1110/Ps.04964705  0.646
2003 Powell DW, Rane MJ, Joughin BA, Kalmukova R, Hong JH, Tidor B, Dean WL, Pierce WM, Klein JB, Yaffe MB, McLeish KR. Proteomic identification of 14-3-3ζ as a mitogen-activated protein kinase-activated protein kinase 2 substrate: Role in dimer formation and ligand binding Molecular and Cellular Biology. 23: 5376-5387. PMID 12861023 DOI: 10.1128/Mcb.23.15.5376-5387.2003  0.719
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