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David A Griffith - Publications

Affiliations: 
Pfizer, Cambridge, MA 
Area:
Medicinal Chemistry
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21 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Limberakis C, Smith AC, Bagley SW, Yayla HG, Kung DW, Griffith DA. Convergent Syntheses of Isomeric Imidazolospiroketones as Templates for Acetyl-CoA Carboxylase (ACC) Inhibitors. The Journal of Organic Chemistry. PMID 37751412 DOI: 10.1021/acs.joc.3c01374  0.309
2012 Bhattacharya SK, Aspnes GE, Bagley SW, Boehm M, Brosius AD, Buckbinder L, Chang JS, Dibrino J, Eng H, Frederick KS, Griffith DA, Griffor MC, Guimarães CR, Guzman-Perez A, Han S, et al. Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 7523-9. PMID 23153798 DOI: 10.1016/J.Bmcl.2012.10.039  0.582
2012 Huard K, Bagley SW, Menhaji-Klotz E, Préville C, Southers JA, Smith AC, Edmonds DJ, Lucas JC, Dunn MF, Allanson NM, Blaney EL, Garcia-Irizarry CN, Kohrt JT, Griffith DA, Dow RL. Synthesis of spiropiperidine lactam acetyl-CoA carboxylase inhibitors. The Journal of Organic Chemistry. 77: 10050-7. PMID 23127254 DOI: 10.1021/jo3014808  0.313
2010 Kalgutkar AS, Griffith DA, Ryder T, Sun H, Miao Z, Bauman JN, Didiuk MT, Frederick KS, Zhao SX, Prakash C, Soglia JR, Bagley SW, Bechle BM, Kelley RM, Dirico K, et al. Discovery tactics to mitigate toxicity risks due to reactive metabolite formation with 2-(2-hydroxyaryl)-5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3h)-one derivatives, potent calcium-sensing receptor antagonists and clinical candidate(s) for the treatment of osteoporosis. Chemical Research in Toxicology. 23: 1115-26. PMID 20507089 DOI: 10.1021/Tx100137N  0.621
2010 Li J, Kung DW, Griffith DA. ChemInform Abstract: Synthesis of 5-Hydroxyquinolines. Cheminform. 41: no-no. DOI: 10.1002/CHIN.201046141  0.302
2010 DANISHEFSKY SJ, GERVAY J, PETERSON JM, MCDONALD FE, KOSEKI K, GRIFFITH DA, ORIYAMA T, MARSDEN S. P. MSP. ChemInform Abstract: Application of Glycals to the Synthesis of Oligosaccharides: Convergent Total Syntheses of the Lewis X Trisaccharide Sialyl Lewis X Antigenic Determinant and Higher Congeners. Cheminform. 26: no-no. DOI: 10.1002/chin.199529277  0.583
2010 DANISHEFSKY SJ, KOSEKI K, GRIFFITH DA, GERVAY J, PETERSON JM, MCDONALD FE, ORIYAMA T. ChemInform Abstract: Azaglycosylation of Complex Stannyl Alkoxides with Glycal-Derived Iodo Sulfonamides: A Straightforward Synthesis of Sialyl-Lewis X Antigen and Other Oligosaccharide Domains. Cheminform. 24: no-no. DOI: 10.1002/CHIN.199305270  0.567
2010 DANISHEFSKY SJ, GERVAY J, PETERSON JM, MCDONALD FE, KOSEKI K, ORIYAMA T, GRIFFITH DA, WONG C, DUMAS DP. ChemInform Abstract: Remarkable Regioselectivity in the Chemical Glycosylation of Glycal Acceptors: A Concise Solution to the Synthesis of Sialyl-Lewis X Glycal. Cheminform. 24: no-no. DOI: 10.1002/chin.199305269  0.573
2010 GRIFFITH DA, DANISHEFSKY SJ. ChemInform Abstract: Total Synthesis of Allosamidin: An Application of the Sulfonamidoglycosylation of Glycals. Cheminform. 22: no-no. DOI: 10.1002/chin.199144276  0.457
2009 Didiuk MT, Griffith DA, Benbow JW, Liu KK, Walker DP, Bi FC, Morris J, Guzman-Perez A, Gao H, Bechle BM, Kelley RM, Yang X, Dirico K, Ahmed S, Hungerford W, et al. Short-acting 5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as orally-active calcium-sensing receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 19: 4555-9. PMID 19625189 DOI: 10.1016/J.Bmcl.2009.07.004  0.625
2009 Zawistoski MP, Decker SM, Griffith DA. Synthesis of 4,5-disubstituted-3-trihalomethylisothiazoles Tetrahedron Letters. 50: 7286-7287. DOI: 10.1016/J.TETLET.2009.10.051  0.308
2000 Hecker SJ, Glinka TW, Cho A, Zhang ZJ, Price ME, Chamberland S, Griffith D, Lee VJ. Discovery of RWJ-54428 (MC-02,479), a new cephalosporin active against resistant gram-positive bacteria. The Journal of Antibiotics. 53: 1272-81. PMID 11213288 DOI: 10.7164/Antibiotics.53.1272  0.301
1998 Denhart DJ, Griffith DA, Heathcock CH. Synthesis of the tricyclic core of sarain A. Use of formaldehyde in an intramolecular Grigg azomethine ylide cyclization Journal of Organic Chemistry. 63: 9616-9617. DOI: 10.1021/Jo981801B  0.526
1996 Griffith DA, Danishefsky SJ. The Total Synthesis of Allosamidin. Expansions of the Methodology of Azaglycosylation Pursuant to the Total Synthesis of Allosamidin. A Surprising Enantiotopic Sense for a Lipase-Induced Deacetylation Journal of the American Chemical Society. 118: 9526-9538. DOI: 10.1021/Ja960526C  0.379
1995 Heathcock CH, Clasby M, Griffith DA, Henke BR, Sharp MJ. Progress toward the Synthesis of Sarain A Synlett. 1995: 467-474. DOI: 10.1055/S-1995-5298  0.495
1995 Danishefsky SJ, Gervay J, Peterson JM, McDonald FE, Koseki K, Griffith DA, Oriyama T, Marsden SP. Application of Glycals to the Synthesis of Oligosaccharides: Convergent Total Syntheses of the Lewis X Trisaccharide Sialyl Lewis X Antigenic Determinant and Higher Congeners Journal of the American Chemical Society. 117: 1940-1953. DOI: 10.1021/Ja00112A007  0.634
1995 Griffith DA, Heathcock CH. Progress toward the synthesis of sarain A: An unanticipated rearrangement Tetrahedron Letters. 36: 2381-2384. DOI: 10.1016/0040-4039(95)00283-I  0.496
1992 Danishefsky SJ, Koseki K, Griffith DA, Gervay J, Peterson JM, McDonald FE, Oriyama T. Azaglycosylation of complex stannyl alkoxides with glycal-derived iodo sulfonamides: a straightforward synthesis of sialyl-Lewis X antigen and other oligosaccharide domains Journal of the American Chemical Society. 114: 8331-8333. DOI: 10.1021/ja00047a078  0.561
1992 Danishefsky SJ, Gervay J, Peterson JM, McDonald FE, Koseki K, Oriyama T, Griffith DA, Wong CH, Dumas DP. Remarkable regioselectivity in the chemical glycosylation of glycal acceptors: a concise solution to the synthesis of sialyl-Lewis X glycal. Journal of the American Chemical Society. 114: 8329-8331. DOI: 10.1021/ja00047a077  0.567
1991 Griffith DA, Danishefsky SJ. Total synthesis of allosamidin : an application of the sulfonamidoglycosylation of glycals Journal of the American Chemical Society. 113: 5863-5864. DOI: 10.1021/Ja00015A051  0.379
1990 Griffith DA, Danishefsky SJ. Sulfonamidoglycosylation of glycals. A route to oligosaccharides with 2-aminohexose subunits Journal of the American Chemical Society. 112: 5811-5819. DOI: 10.1021/Ja00171A021  0.404
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