| Year |
Citation |
Score |
| 2022 |
Papa A, Pasquini S, Galvani F, Cammarota M, Contri C, Carullo G, Gemma S, Ramunno A, Lamponi S, Gorelli B, Saponara S, Varani K, Mor M, Campiani G, Boscia F, et al. Development of potent and selective FAAH inhibitors with improved drug-like properties as potential tools to treat neuroinflammatory conditions. European Journal of Medicinal Chemistry. 246: 114952. PMID 36462439 DOI: 10.1016/j.ejmech.2022.114952 |
0.305 |
|
| 2020 |
Guidi A, Prasanth Saraswati A, Relitti N, Gimmelli R, Saccoccia F, Sirignano C, Taglialatela-Scafati O, Campiani G, Ruberti G, Gemma S. (+)-(R)- and (-)-(S)-Perhexiline maleate: Enantioselective synthesis and functional studies on Schistosoma mansoni larval and adult stages. Bioorganic Chemistry. 102: 104067. PMID 32663671 DOI: 10.1016/J.Bioorg.2020.104067 |
0.309 |
|
| 2020 |
Frydenvang K, Pickering DS, Kshirsagar GU, Chemi G, Gemma S, Sprogøe D, Kærn AM, Brogi S, Campiani G, Butini S, Kastrup JS. The ionotropic glutamate receptor GluA2 in complex with bicyclic pyrimidinedione-based compounds: when small compound modifications have distinct effects on binding interactions. Acs Chemical Neuroscience. PMID 32437601 DOI: 10.1021/Acschemneuro.0C00195 |
0.361 |
|
| 2020 |
Sirous H, Campiani G, Brogi S, Calderone V, Chemi G. Computer-Driven Development of an in Silico Tool for Finding Selective Histone Deacetylase 1 Inhibitors. Molecules (Basel, Switzerland). 25. PMID 32331470 DOI: 10.3390/Molecules25081952 |
0.345 |
|
| 2020 |
Relitti N, Saraswati AP, Federico S, Khan T, Brindisi M, Zisterer D, Brogi S, Gemma S, Butini S, Campiani G. Telomerase-based Cancer Therapeutics: A Review on their Clinical Trials. Current Topics in Medicinal Chemistry. 20: 433-457. PMID 31894749 DOI: 10.2174/1568026620666200102104930 |
0.303 |
|
| 2019 |
Battah B, Chemi G, Butini S, Campiani G, Brogi S, Delogu G, Gemma S. A Repurposing Approach for Uncovering the Anti-Tubercular Activity of FDA-Approved Drugs with Potential Multi-Targeting Profiles. Molecules (Basel, Switzerland). 24. PMID 31795400 DOI: 10.3390/Molecules24234373 |
0.315 |
|
| 2019 |
Saccoccia F, Brindisi M, Gimmelli R, Relitti N, Guidi A, Saraswati AP, Cavella C, Brogi S, Chemi G, Butini S, Papoff G, Senger J, Herp D, Jung M, Campiani G, et al. Screening and phenotypical characterization of Schistosoma mansoni histone deacetylase 8 (SmHDAC8) inhibitors as multi-stage antischistosomal agents. Acs Infectious Diseases. PMID 31661956 DOI: 10.1021/Acsinfecdis.9B00224 |
0.356 |
|
| 2019 |
Grillo A, Chemi G, Brogi S, Brindisi M, Relitti N, Fezza F, Fazio D, Castelletti L, Perdona E, Wong A, Lamponi S, Pecorelli A, Benedusi M, Fantacci M, Valoti M, ... ... Campiani G, et al. Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems. European Journal of Medicinal Chemistry. 183: 111674. PMID 31518969 DOI: 10.1016/J.Ejmech.2019.111674 |
0.392 |
|
| 2019 |
Sirous H, Chemi G, Campiani G, Brogi S. An integrated in silico screening strategy for identifying promising disruptors of p53-MDM2 interaction. Computational Biology and Chemistry. 83: 107105. PMID 31473433 DOI: 10.1016/J.Compbiolchem.2019.107105 |
0.378 |
|
| 2019 |
Sirous H, Chemi G, Gemma S, Butini S, Debyser Z, Christ F, Saghaie L, Brogi S, Fassihi A, Campiani G, Brindisi M. Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using Structure-Based Combinatorial Library Design Approach. Frontiers in Chemistry. 7: 574. PMID 31457006 DOI: 10.3389/Fchem.2019.00574 |
0.304 |
|
| 2019 |
D'Alessandro S, Alfano G, Di Cerbo L, Brogi S, Chemi G, Relitti N, Brindisi M, Lamponi S, Novellino E, Campiani G, Gemma S, Basilico N, Taramelli D, Baratto MC, Pogni R, et al. Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II). Bioorganic Chemistry. 89: 103020. PMID 31185392 DOI: 10.1016/J.Bioorg.2019.103020 |
0.363 |
|
| 2019 |
Saraswati AP, Relitti N, Brindisi M, Gemma S, Zisterer D, Butini S, Campiani G. Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors. Drug Discovery Today. 24: 1370-1388. PMID 31136800 DOI: 10.1016/J.Drudis.2019.05.015 |
0.326 |
|
| 2019 |
da Silva ER, Brogi S, Lucon-Júnior JF, Campiani G, Gemma S, Maquiaveli CDC. Dietary polyphenols rutin, taxifolin and quercetin related compounds target Leishmania amazonensis arginase. Food & Function. PMID 31134235 DOI: 10.1039/C9Fo00265K |
0.337 |
|
| 2018 |
Brindisi M, Ulivieri C, Alfano G, Gemma S, de Asís Balaguer F, Khan T, Grillo A, Chemi G, Menchon G, Prota AE, Olieric N, Lucena-Agell D, Barasoain I, Diaz JF, Nebbioso A, ... ... Campiani G, et al. Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents. European Journal of Medicinal Chemistry. 162: 290-320. PMID 30448418 DOI: 10.1016/J.Ejmech.2018.11.004 |
0.412 |
|
| 2018 |
da Silva ER, Brogi S, Grillo A, Campiani G, Gemma S, Vieira PC, do Carmo Maquiaveli C. Cinnamic acids derived compounds with antileishmanial activity target Leishmania amazonensis arginase. Chemical Biology & Drug Design. PMID 30216691 DOI: 10.1111/Cbdd.13391 |
0.365 |
|
| 2018 |
Janssen APA, Van der Vliet D, Bakker AT, Jiang M, Grimm SH, Campiani G, Butini S, van der Stelt M. Development of a multiplexed activity-based protein profiling assay to evaluate activity of endocannabinoid hydrolase inhibitors. Acs Chemical Biology. PMID 30199617 DOI: 10.1021/Acschembio.8B00534 |
0.329 |
|
| 2018 |
Brindisi M, Senger J, Cavella C, Grillo A, Chemi G, Gemma S, Cucinella DM, Lamponi S, Sarno F, Iside C, Nebbioso A, Novellino E, Shaik TB, Romier C, Herp D, ... ... Campiani G, et al. Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies. European Journal of Medicinal Chemistry. 157: 127-138. PMID 30092367 DOI: 10.1016/J.Ejmech.2018.07.069 |
0.429 |
|
| 2018 |
Brindisi M, Borrelli G, Brogi S, Grillo A, Maramai S, Paolino M, Benedusi M, Pecorelli A, Valacchi G, Di Cesare Mannelli L, Ghelardini C, Allarà M, Ligresti A, Minetti P, Campiani G, et al. Development of Potent Inhibitors of Fatty Acid Amide Hydrolase Useful for the Treatment of Neuropathic Pain. Chemmedchem. 13: 2090-2103. PMID 30085402 DOI: 10.1002/Cmdc.201800397 |
0.416 |
|
| 2018 |
Vallone A, D'Alessandro S, Brogi S, Brindisi M, Chemi G, Alfano G, Lamponi S, Lee SG, Jez JM, Koolen KJM, Dechering KJ, Saponara S, Fusi F, Gorelli B, Taramelli D, ... ... Campiani G, et al. Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues. European Journal of Medicinal Chemistry. 150: 698-718. PMID 29571157 DOI: 10.1016/J.Ejmech.2018.03.024 |
0.357 |
|
| 2018 |
Brogi S, Brindisi M, Butini S, Kshirsagar GU, Maramai S, Chemi G, Gemma S, Campiani G, Novellino E, Fiorenzani P, Pinassi J, Aloisi AM, Gynther M, Venskutonyte R, Han L, et al. (S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements, Structural and Biological Investigation. Journal of Medicinal Chemistry. PMID 29451794 DOI: 10.1021/Acs.Jmedchem.8B00099 |
0.341 |
|
| 2018 |
Paolino M, Brindisi M, Vallone A, Butini S, Campiani G, Nannicini C, Giuliani G, Anzini M, Lamponi S, Giorgi G, Sbardella D, Ferraris DM, Marini S, Coletta M, Palucci I, et al. Development of potent inhibitors of the Mycobacterium tuberculosis virulence factor Zmp1 and evaluation of their effect on mycobacterial survival inside macrophages. Chemmedchem. PMID 29334428 DOI: 10.1002/Cmdc.201700759 |
0.325 |
|
| 2018 |
Chouha N, Hammoud H, Brogi S, Campiani G, Welsch C, Robert C, Vagner S, Cresteil T, Bentouhami E, Désaubry L. Discovery of Iminobenzimidazole Derivatives as Novel Cytotoxic Agents The Open Medicinal Chemistry Journal. 12: 74-83. DOI: 10.2174/1874104501812010074 |
0.338 |
|
| 2018 |
Federico S, Khan T, Relitti N, Chemi G, Brindisi M, Brogi S, Novellino E, Zisterer DM, Campiani G, Gemma S, Butini S. A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents Tetrahedron Letters. 59: 4466-4470. DOI: 10.1016/J.Tetlet.2018.11.005 |
0.335 |
|
| 2018 |
Gemma S, Cerbo Ld, Relitti N, Vallone A, Brindisi M, Brogi S, Chemi G, Novellino E, Campiani G, Butini S. Synthetic studies toward bicyclic endoperoxides presenting polar side chains Tetrahedron Letters. 59: 4330-4333. DOI: 10.1016/J.Tetlet.2018.10.059 |
0.339 |
|
| 2017 |
Brogi S, Maramai S, Brindisi M, Chemi G, Porcari V, Corallo C, Gennari L, Novellino E, Ramunno A, Butini S, Campiani G, Gemma S. Activation of the Wnt Pathway by Small Peptides: Rational Design, Synthesis and Biological Evaluation. Chemmedchem. 12: 2074-2085. PMID 29131552 DOI: 10.1002/Cmdc.201700551 |
0.345 |
|
| 2017 |
Brogi S, Ramunno A, Savi L, Chemi G, Alfano G, Pecorelli A, Pambianchi E, Galatello P, Compagnoni G, Focher F, Biamonti G, Valacchi G, Butini S, Gemma S, Campiani G, et al. First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents. European Journal of Medicinal Chemistry. 138: 438-457. PMID 28689095 DOI: 10.1016/J.Ejmech.2017.06.017 |
0.415 |
|
| 2017 |
Chemi G, Gemma S, Campiani G, Brogi S, Butini S, Brindisi M. Computational Tool for Fast Evaluation of ERG K Channel Affinity. Frontiers in Chemistry. 5: 7. PMID 28503546 DOI: 10.3389/Fchem.2017.00007 |
0.317 |
|
| 2017 |
Brogi S, Fiorillo A, Chemi G, Butini S, Lalle M, Ilari A, Gemma S, Campiani G. Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX. European Journal of Medicinal Chemistry. 135: 479-490. PMID 28477573 DOI: 10.1016/J.Ejmech.2017.04.057 |
0.364 |
|
| 2017 |
Zaccagnini L, Brogi S, Brindisi M, Gemma S, Chemi G, Legname G, Campiani G, Butini S. Identification of novel fluorescent probes preventing PrP replication in prion diseases. European Journal of Medicinal Chemistry. 127: 859-873. PMID 27842893 DOI: 10.1016/J.Ejmech.2016.10.064 |
0.317 |
|
| 2017 |
Ismaili L, Refouvelet B, Benchekroun M, Brogi S, Brindisi M, Gemma S, Campiani G, Filipic S, Agbaba D, Esteban G, Unzeta M, Nikolic K, Butini S, Marco-Contelles J. Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease. Progress in Neurobiology. 151: 4-34. PMID 26797191 DOI: 10.1016/J.Pneurobio.2015.12.003 |
0.326 |
|
| 2016 |
Greene LM, Butini S, Campiani G, Williams DC, Zisterer DM. Pre-clinical evaluation of a novel class of anti-cancer agents, the Pyrrolo-1, 5-benzoxazepines. Journal of Cancer. 7: 2367-2377. PMID 27994676 DOI: 10.7150/Jca.16616 |
0.349 |
|
| 2016 |
Maramai S, Gemma S, Brogi S, Campiani G, Butini S, Stark H, Brindisi M. Dopamine D3 Receptor Antagonists as Potential Therapeutics for the Treatment of Neurological Diseases. Frontiers in Neuroscience. 10: 451. PMID 27761108 DOI: 10.3389/Fnins.2016.00451 |
0.332 |
|
| 2016 |
Brindisi M, Cavella C, Brogi S, Nebbioso A, Senger J, Maramai S, Ciotta A, Iside C, Butini S, Lamponi S, Novellino E, Altucci L, Jung M, Campiani G, Gemma S. Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies. Future Medicinal Chemistry. PMID 27556815 DOI: 10.4155/Fmc-2016-0068 |
0.338 |
|
| 2016 |
Lennon JC, Butini S, Campiani G, O'Meara A, Williams DC, Zisterer DM. Involvement of AMP-activated protein kinase in mediating pyrrolo-1,5-benzoxazepine-induced apoptosis in neuroblastoma cells. Investigational New Drugs. PMID 27334143 DOI: 10.1007/S10637-016-0366-3 |
0.382 |
|
| 2016 |
Butini S, Nikolic K, Kassel S, Brückmann H, Filipic S, Agbaba D, Gemma S, Brogi S, Brindisi M, Campiani G, Stark H. Polypharmacology of dopamine receptor ligands Progress in Neurobiology. 142: 68-103. PMID 27234980 DOI: 10.1016/J.Pneurobio.2016.03.011 |
0.309 |
|
| 2016 |
Nathwani SM, Greene LM, Butini S, Campiani G, Williams DC, Samali A, Szegezdi E, Zisterer DM. The pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAIL‑induced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells. International Journal of Oncology. PMID 27176505 DOI: 10.3892/Ijo.2016.3518 |
0.345 |
|
| 2016 |
Brindisi M, Maramai S, Brogi S, Fanigliulo E, Butini S, Guarino E, Casagni A, Lamponi S, Bonechi C, Nathwani SM, Finetti F, Ragonese F, Arcidiacono P, Campiglia P, Valenti S, ... ... Campiani G, et al. Development of novel cyclic peptides as pro-apoptotic agents. European Journal of Medicinal Chemistry. 117: 301-320. PMID 27150036 DOI: 10.1016/J.Ejmech.2016.04.001 |
0.302 |
|
| 2016 |
Brindisi M, Brogi S, Giovani S, Gemma S, Lamponi S, De Luca F, Novellino E, Campiani G, Docquier JD, Butini S. Targeting clinically-relevant metallo-β-lactamases: from high-throughput docking to broad-spectrum inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 1-12. PMID 27121013 DOI: 10.3109/14756366.2016.1172575 |
0.306 |
|
| 2016 |
Maquiaveli CC, Lucon-Júnior JF, Brogi S, Campiani G, Gemma S, Vieira PC, Silva ER. Verbascoside Inhibits Promastigote Growth and Arginase Activity of Leishmania amazonensis. Journal of Natural Products. 79: 1459-63. PMID 27096224 DOI: 10.1021/Acs.Jnatprod.5B00875 |
0.363 |
|
| 2016 |
Brindisi M, Maramai S, Gemma S, Brogi S, Grillo A, Di Cesare Mannelli L, Gabellieri E, Lamponi S, Saponara S, Gorelli B, Tedesco D, Bonfiglio T, Landry C, Jung KM, Armirotti A, ... ... Campiani G, et al. Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. Journal of Medicinal Chemistry. PMID 26888301 DOI: 10.1021/Acs.Jmedchem.5B01812 |
0.335 |
|
| 2016 |
Kinsella P, Greene LM, Bright SA, Pollock JK, Butini S, Campiani G, Bauer S, Williams DC, Zisterer DM. The novel pyrrolo-1,5-benzoxazepine, PBOX-15, synergistically enhances the apoptotic efficacy of imatinib in gastrointestinal stromal tumours; suggested mechanism of action of PBOX-15. Investigational New Drugs. 34: 159-67. PMID 26885657 DOI: 10.1007/S10637-016-0331-1 |
0.368 |
|
| 2016 |
Brogi S, Giovani S, Brindisi M, Gemma S, Novellino E, Campiani G, Blackman MJ, Butini S. In silico study of subtilisin-like protease 1 (SUB1) from different Plasmodium species in complex with peptidyl-difluorostatones and characterization of potent pan-SUB1 inhibitors. Journal of Molecular Graphics & Modelling. 64: 121-30. PMID 26826801 DOI: 10.1016/J.Jmgm.2016.01.005 |
0.333 |
|
| 2016 |
Brindisi M, Brogi S, Maramai S, Grillo A, Borrelli G, Butini S, Novellino E, Allarà M, Ligresti A, Campiani G, Marzo VD, Gemma S. Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: definition of the structural determinants for enzyme inhibition Rsc Advances. 6: 64651-64664. DOI: 10.1039/C6Ra12524G |
0.359 |
|
| 2015 |
Wu MY, Esteban G, Brogi S, Shionoya M, Wang L, Campiani G, Unzeta M, Inokuchi T, Butini S, Marco-Contelles J. Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation. European Journal of Medicinal Chemistry. PMID 26471320 DOI: 10.1016/J.Ejmech.2015.10.001 |
0.363 |
|
| 2015 |
Brogi S, Brindisi M, Joshi BP, Sanna Coccone S, Parapini S, Basilico N, Novellino E, Campiani G, Gemma S, Butini S. Exploring clotrimazole-based pharmacophore: 3D-QSAR studies and synthesis of novel antiplasmodial agents. Bioorganic & Medicinal Chemistry Letters. 25: 5412-8. PMID 26428874 DOI: 10.1016/J.Bmcl.2015.09.007 |
0.368 |
|
| 2015 |
Fiore D, Proto MC, Pisanti S, Picardi P, Pagano Zottola AC, Butini S, Gemma S, Casagni A, Laezza C, Vitale M, Ligresti A, Di Marzo V, Zisterer DM, Nathwani S, Williams DC, ... Campiani G, et al. Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells. Cancer Biology & Therapy. 0. PMID 26392056 DOI: 10.1080/15384047.2015.1078028 |
0.369 |
|
| 2015 |
Spallarossa A, Caneva C, Caviglia M, Alfei S, Butini S, Campiani G, Gemma S, Brindisi M, Zisterer DM, Bright SA, Williams CD, Crespan E, Maga G, Sanna G, Delogu I, et al. Unconventional Knoevenagel-type indoles: Synthesis and cell-based studies for the identification of pro-apoptotic agents. European Journal of Medicinal Chemistry. 102: 648-60. PMID 26320088 DOI: 10.1016/J.Ejmech.2015.08.009 |
0.401 |
|
| 2015 |
Savi L, Brindisi M, Alfano G, Butini S, La Pietra V, Novellino E, Marinelli L, Lossani A, Focher F, Cavella C, Campiani G, Gemma S. Site-directed Mutagenesis of Key Residues Unveiled a Novel Allosteric Site on Human Adenosine Kinase for Pyrrolobenzoxa(thia)zepinone Non-Nucleoside Inhibitors. Chemical Biology & Drug Design. PMID 26242695 DOI: 10.1111/Cbdd.12630 |
0.341 |
|
| 2015 |
O'Callaghan K, Palagano E, Butini S, Campiani G, Williams DC, Zisterer DM, O'Sullivan J. Induction of apoptosis in oral squamous carcinoma cells by pyrrolo-1,5-benzoxazepines. Molecular Medicine Reports. PMID 26005189 DOI: 10.3892/Mmr.2015.3832 |
0.339 |
|
| 2015 |
Brindisi M, Brogi S, Relitti N, Vallone A, Butini S, Gemma S, Novellino E, Colotti G, Angiulli G, Di Chiaro F, Fiorillo A, Ilari A, Campiani G. Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking. Scientific Reports. 5: 9705. PMID 25951439 DOI: 10.1038/Srep09705 |
0.407 |
|
| 2015 |
Giovani S, Penzo M, Butini S, Brindisi M, Gemma S, Novellino E, Campiani G, Blackman MJ, Brogi S. Plasmodium falciparum subtilisin-like protease 1: discovery of potent difluorostatone-based inhibitors Rsc Advances. 5: 22431-22448. DOI: 10.1039/C5Ra01170A |
0.325 |
|
| 2015 |
Brindisi M, Gemma S, Kunjir SA, Cerbo LD, Brogi S, Parapini S, D'Alessandro S, Taramelli D, Habluetzel A, Tapanelli S, Lamponi S, Novellino E, Campiani G, Butini S. Synthetic spirocyclic endoperoxides: new antimalarial scaffolds Medchemcomm. 6: 357-362. DOI: 10.1039/C4Md00454J |
0.335 |
|
| 2014 |
Brogi S, Butini S, Maramai S, Colombo R, Verga L, Lanni C, De Lorenzi E, Lamponi S, Andreassi M, Bartolini M, Andrisano V, Novellino E, Campiani G, Brindisi M, Gemma S. Disease-modifying anti-Alzheimer's drugs: inhibitors of human cholinesterases interfering with β-amyloid aggregation. Cns Neuroscience & Therapeutics. 20: 624-32. PMID 24935788 DOI: 10.1111/Cns.12290 |
0.326 |
|
| 2014 |
Giovani S, Penzo M, Brogi S, Brindisi M, Gemma S, Novellino E, Savini L, Blackman MJ, Campiani G, Butini S. Rational design of the first difluorostatone-based PfSUB1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 24: 3582-6. PMID 24909083 DOI: 10.1016/J.Bmcl.2014.05.044 |
0.394 |
|
| 2014 |
Castriconi F, Paolino M, Giuliani G, Anzini M, Campiani G, Mennuni L, Sabatini C, Lanza M, Caselli G, De Rienzo F, Menziani MC, Sbraccia M, Molinari P, Costa T, Cappelli A. Synthesis and structure-activity relationship studies in serotonin 5-HT4 receptor ligands based on a benzo[de][2,6]naphthridine scaffold. European Journal of Medicinal Chemistry. 82: 36-46. PMID 24871995 DOI: 10.1016/J.Ejmech.2014.05.015 |
0.359 |
|
| 2014 |
Lennon JC, Bright SA, Carroll E, Butini S, Campiani G, O'Meara A, Williams DC, Zisterer DM. The novel pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the apoptotic effects of carboplatin in drug sensitive and multidrug resistant neuroblastoma cells. Biochemical Pharmacology. 87: 611-24. PMID 24406249 DOI: 10.1016/J.Bcp.2013.12.017 |
0.378 |
|
| 2014 |
Gemma S, Brogi S, Patil PR, Giovani S, Lamponi S, Cappelli A, Novellino E, Brown A, Higgins MK, Mustafa K, Szestak T, Craig AG, Campiani G, Butini S, Brindisi M. From (+)-epigallocatechin gallate to a simplified synthetic analogue as a cytoadherence inhibitor for P. falciparum Rsc Adv.. 4: 4769-4781. DOI: 10.1039/C3Ra45933K |
0.353 |
|
| 2013 |
Butini S, Brindisi M, Brogi S, Maramai S, Guarino E, Panico A, Saxena A, Chauhan V, Colombo R, Verga L, De Lorenzi E, Bartolini M, Andrisano V, Novellino E, Campiani G, et al. Multifunctional cholinesterase and amyloid Beta fibrillization modulators. Synthesis and biological investigation. Acs Medicinal Chemistry Letters. 4: 1178-82. PMID 24900626 DOI: 10.1021/Ml4002908 |
0.316 |
|
| 2013 |
Butini S, Gabellieri E, Brindisi M, Giovani S, Maramai S, Kshirsagar G, Guarino E, Brogi S, La Pietra V, Giustiniano M, Marinelli L, Novellino E, Campiani G, Cappelli A, Gemma S. A stereoselective approach to peptidomimetic BACE1 inhibitors. European Journal of Medicinal Chemistry. 70: 233-47. PMID 24158015 DOI: 10.1016/J.Ejmech.2013.09.056 |
0.395 |
|
| 2013 |
Butini S, Brogi S, Novellino E, Campiani G, Ghosh AK, Brindisi M, Gemma S. The structural evolution of β-secretase inhibitors: a focus on the development of small-molecule inhibitors. Current Topics in Medicinal Chemistry. 13: 1787-807. PMID 23931442 DOI: 10.2174/15680266113139990137 |
0.337 |
|
| 2013 |
Gangemi G, Gazzerro P, Fiore D, Proto MC, Butini S, Gemma S, Casagni A, Laezza C, Vitale M, Ligresti A, Di Marzo V, Zisterer DM, Nathwani S, Clive Williams D, Campiani G, et al. PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines. European Journal of Pharmacology. 714: 379-87. PMID 23872382 DOI: 10.1016/J.Ejphar.2013.07.011 |
0.374 |
|
| 2013 |
Cappelli A, Manini M, Valenti S, Castriconi F, Giuliani G, Anzini M, Brogi S, Butini S, Gemma S, Campiani G, Giorgi G, Mennuni L, Lanza M, Giordani A, Caselli G, et al. Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds. European Journal of Medicinal Chemistry. 63: 85-94. PMID 23466604 DOI: 10.1016/J.Ejmech.2013.01.044 |
0.352 |
|
| 2013 |
Butini S, Gemma S, Brindisi M, Maramai S, Minetti P, Celona D, Napolitano R, Borsini F, Cabri W, Fezza F, Merlini L, Dallavalle S, Campiani G, Maccarrone M. Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties. Bioorganic & Medicinal Chemistry Letters. 23: 492-5. PMID 23237837 DOI: 10.1016/J.Bmcl.2012.11.035 |
0.395 |
|
| 2013 |
Butini S, Gabellieri E, Brindisi M, Casagni A, Guarino E, Huleatt PB, Relitti N, La Pietra V, Marinelli L, Giustiniano M, Novellino E, Campiani G, Gemma S. Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies. Bioorganic & Medicinal Chemistry Letters. 23: 85-9. PMID 23218605 DOI: 10.1016/J.Bmcl.2012.11.011 |
0.415 |
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| 2013 |
Lysaght J, Verma NK, Maginn EN, Ryan JM, Campiani G, Zisterer DM, Williams DC, Browne PV, Lawler MP, McElligott AM. The microtubule targeting agent PBOX-15 inhibits integrin-mediated cell adhesion and induces apoptosis in acute lymphoblastic leukaemia cells. International Journal of Oncology. 42: 239-46. PMID 23135704 DOI: 10.3892/Ijo.2012.1688 |
0.313 |
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| 2013 |
Brindisi M, Gemma S, Alfano G, Kshirsagar G, Novellino E, Campiani G, Butini S. A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues Tetrahedron Letters. 54: 5387-5390. DOI: 10.1016/J.Tetlet.2013.07.115 |
0.305 |
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| 2013 |
Gemma S, Kunjir S, Brindisi M, Novellino E, Campiani G, Butini S. A synthetic strategy to bridged 2,3,8-trioxabicyclo[3,3,1]nonane endoperoxides Tetrahedron Letters. 54: 1233-1235. DOI: 10.1016/J.Tetlet.2012.12.075 |
0.314 |
|
| 2012 |
Gemma S, Camodeca C, Brindisi M, Brogi S, Kukreja G, Kunjir S, Gabellieri E, Lucantoni L, Habluetzel A, Taramelli D, Basilico N, Gualdani R, Tadini-Buoninsegni F, Bartolommei G, Moncelli MR, ... ... Campiani G, et al. Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents. Journal of Medicinal Chemistry. 55: 10387-404. PMID 23145816 DOI: 10.1021/Jm300831B |
0.367 |
|
| 2012 |
Gemma S, Giovani S, Brindisi M, Tripaldi P, Brogi S, Savini L, Fiorini I, Novellino E, Butini S, Campiani G, Penzo M, Blackman MJ. Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1. Bioorganic & Medicinal Chemistry Letters. 22: 5317-21. PMID 22796182 DOI: 10.1016/J.Bmcl.2012.06.023 |
0.404 |
|
| 2012 |
Gemma S, Camodeca C, Sanna Coccone S, Joshi BP, Bernetti M, Moretti V, Brogi S, Bonache de Marcos MC, Savini L, Taramelli D, Basilico N, Parapini S, Rottmann M, Brun R, Lamponi S, ... ... Campiani G, et al. Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling. Journal of Medicinal Chemistry. 55: 6948-67. PMID 22783984 DOI: 10.1021/Jm300802S |
0.348 |
|
| 2012 |
Butini S, Brindisi M, Gemma S, Minetti P, Cabri W, Gallo G, Vincenti S, Talamonti E, Borsini F, Caprioli A, Stasi MA, Di Serio S, Ros S, Borrelli G, Maramai S, ... ... Campiani G, et al. Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases Journal of Medicinal Chemistry. 55: 6898-6915. PMID 22779702 DOI: 10.1021/Jm300689C |
0.398 |
|
| 2011 |
Patil PR, Gemma S, Campiani G, Craig AG. Broad inhibition of plasmodium falciparum cytoadherence by (+)-epigallocatechin gallate. Malaria Journal. 10: 348. PMID 22132804 DOI: 10.1186/1475-2875-10-348 |
0.32 |
|
| 2011 |
Gemma S, Kunjir S, Coccone SS, Brindisi M, Moretti V, Brogi S, Novellino E, Basilico N, Parapini S, Taramelli D, Campiani G, Butini S. Synthesis and antiplasmodial activity of bicyclic dioxanes as simplified dihydroplakortin analogues. Journal of Medicinal Chemistry. 54: 5949-53. PMID 21761935 DOI: 10.1021/Jm200686D |
0.388 |
|
| 2011 |
Butini S, Gemma S, Brindisi M, Borrelli G, Fiorini I, Samuele A, Karytinos A, Facchini M, Lossani A, Zanoli S, Campiani G, Novellino E, Focher F, Maga G. Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants. Bioorganic & Medicinal Chemistry Letters. 21: 3935-8. PMID 21636271 DOI: 10.1016/J.Bmcl.2011.05.020 |
0.303 |
|
| 2011 |
Gemma S, Colombo L, Forloni G, Savini L, Fracasso C, Caccia S, Salmona M, Brindisi M, Joshi BP, Tripaldi P, Giorgi G, Taglialatela-Scafati O, Novellino E, Fiorini I, Campiani G, et al. Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils. Organic & Biomolecular Chemistry. 9: 5137-48. PMID 21629961 DOI: 10.1039/C1Ob05288H |
0.31 |
|
| 2011 |
Venskutonyte R, Butini S, Coccone SS, Gemma S, Brindisi M, Kumar V, Guarino E, Maramai S, Valenti S, Amir A, Valadés EA, Frydenvang K, Kastrup JS, Novellino E, Campiani G, et al. Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization. Journal of Medicinal Chemistry. 54: 4793-805. PMID 21619066 DOI: 10.1021/Jm2004078 |
0.354 |
|
| 2011 |
Butini S, Gemma S, Brindisi M, Borrelli G, Lossani A, Ponte AM, Torti A, Maga G, Marinelli L, La Pietra V, Fiorini I, Lamponi S, Campiani G, Zisterer DM, Nathwani SM, et al. Non-nucleoside inhibitors of human adenosine kinase: Synthesis, molecular modeling, and biological studies Journal of Medicinal Chemistry. 54: 1401-1420. PMID 21319802 DOI: 10.1021/Jm101438U |
0.378 |
|
| 2011 |
Maginn EN, Browne PV, Hayden P, Vandenberghe E, MacDonagh B, Evans P, Goodyer M, Tewari P, Campiani G, Butini S, Williams DC, Zisterer DM, Lawler MP, McElligott AM. PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells. British Journal of Cancer. 104: 281-9. PMID 21179037 DOI: 10.1038/Sj.Bjc.6606035 |
0.314 |
|
| 2011 |
Gemma S, Butini S, Campiani G, Brindisi M, Zanoli S, Romano MP, Tripaldi P, Savini L, Fiorini I, Borrelli G, Novellino E, Maga G. Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase. Bioorganic & Medicinal Chemistry Letters. 21: 2776-9. PMID 20880703 DOI: 10.1016/J.Bmcl.2010.09.002 |
0.306 |
|
| 2010 |
Nathwani SM, Cloonan SM, Stronach M, Campiani G, Lawler M, Williams DC, Zisterer DM. Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce cell cycle arrest and apoptosis in prostate cancer cells. Oncology Reports. 24: 1499-507. PMID 21042745 DOI: 10.3892/Or_00001011 |
0.34 |
|
| 2010 |
Gemma S, Travagli V, Savini L, Novellino E, Campiani G, Butini S. Malaria chemotherapy: recent advances in drug development. Recent Patents On Anti-Infective Drug Discovery. 5: 195-225. PMID 20738242 DOI: 10.2174/157489110793348776 |
0.308 |
|
| 2010 |
Butini S, Campiani G, Franceschini S, Trotta F, Kumar V, Guarino E, Borrelli G, Fiorini I, Novellino E, Fattorusso C, Persico M, Orteca N, Sandager-Nielsen K, Jacobsen TA, Madsen K, et al. Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors. Journal of Medicinal Chemistry. 53: 4803-7. PMID 20481570 DOI: 10.1021/Jm100294B |
0.31 |
|
| 2010 |
Bright SA, McElligott AM, O'Connell JW, O'Connor L, Carroll P, Campiani G, Deininger MW, Conneally E, Lawler M, Williams DC, Zisterer DM. Novel pyrrolo-1,5-benzoxazepine compounds display significant activity against resistant chronic myeloid leukaemia cells in vitro, in ex vivo patient samples and in vivo. British Journal of Cancer. 102: 1474-82. PMID 20407438 DOI: 10.1038/Sj.Bjc.6605670 |
0.339 |
|
| 2010 |
Bright SA, Campiani G, Deininger MW, Lawler M, Williams DC, Zisterer DM. Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells including those resistant to imatinib treatment. Biochemical Pharmacology. 80: 31-8. PMID 20206141 DOI: 10.1016/J.Bcp.2010.02.019 |
0.393 |
|
| 2010 |
Nathwani SM, Butler S, Fayne D, McGovern NN, Sarkadi B, Meegan MJ, Lloyd DG, Campiani G, Lawler M, Williams DC, Zisterer DM. Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce apoptosis in multi-drug-resistant cancer cells. Cancer Chemotherapy and Pharmacology. 66: 585-96. PMID 20020128 DOI: 10.1007/S00280-009-1200-9 |
0.334 |
|
| 2010 |
Nathwani SM, Butler S, Meegan MJ, Campiani G, Lawler M, Williams DC, Zisterer DM. Dual targeting of tumour cells and host endothelial cells by novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines. Cancer Chemotherapy and Pharmacology. 65: 289-300. PMID 19479253 DOI: 10.1007/S00280-009-1033-6 |
0.34 |
|
| 2010 |
Bartolommei G, Tadini-Buoninsegni F, Gemma S, Camodeca C, Butini S, Campiani G, Moncelli MR. Inhibition of SERCA1 by a Novel Antimalarial Compound Biophysical Journal. 98: 5-5. DOI: 10.1016/J.Bpj.2009.12.2751 |
0.335 |
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| 2009 |
Butini S, Budriesi R, Hamon M, Morelli E, Gemma S, Brindisi M, Borrelli G, Novellino E, Fiorini I, Ioan P, Chiarini A, Cagnotto A, Mennini T, Fracasso C, Caccia S, ... Campiani G, et al. Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization. Journal of Medicinal Chemistry. 52: 6946-50. PMID 19831400 DOI: 10.1021/Jm901126M |
0.35 |
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| 2009 |
McElligott AM, Maginn EN, Greene LM, McGuckin S, Hayat A, Browne PV, Butini S, Campiani G, Catherwood MA, Vandenberghe E, Williams DC, Zisterer DM, Lawler M. The novel tubulin-targeting agent pyrrolo-1,5-benzoxazepine-15 induces apoptosis in poor prognostic subgroups of chronic lymphocytic leukemia. Cancer Research. 69: 8366-75. PMID 19826055 DOI: 10.1158/0008-5472.Can-09-0131 |
0.36 |
|
| 2009 |
Ferlini C, Cicchillitti L, Raspaglio G, Bartollino S, Cimitan S, Bertucci C, Mozzetti S, Gallo D, Persico M, Fattorusso C, Campiani G, Scambia G. Paclitaxel directly binds to Bcl-2 and functionally mimics activity of Nur77. Cancer Research. 69: 6906-14. PMID 19671798 DOI: 10.1158/0008-5472.Can-09-0540 |
0.34 |
|
| 2009 |
Gemma S, Savini L, Altarelli M, Tripaldi P, Chiasserini L, Coccone SS, Kumar V, Camodeca C, Campiani G, Novellino E, Clarizio S, Delogu G, Butini S. Development of antitubercular compounds based on a 4-quinolylhydrazone scaffold. Further structure-activity relationship studies. Bioorganic & Medicinal Chemistry. 17: 6063-72. PMID 19620006 DOI: 10.1016/J.Bmc.2009.06.051 |
0.362 |
|
| 2009 |
Butini S, Brindisi M, Cosconati S, Marinelli L, Borrelli G, Coccone SS, Ramunno A, Campiani G, Novellino E, Zanoli S, Samuele A, Giorgi G, Bergamini A, Di Mattia M, Lalli S, et al. Specific targeting of highly conserved residues in the HIV-1 reverse transcriptase primer grip region. 2. Stereoselective interaction to overcome the effects of drug resistant mutations. Journal of Medicinal Chemistry. 52: 1224-8. PMID 19170521 DOI: 10.1021/Jm801395V |
0.369 |
|
| 2009 |
Gemma S, Campiani G, Butini S, Joshi BP, Kukreja G, Coccone SS, Bernetti M, Persico M, Nacci V, Fiorini I, Novellino E, Taramelli D, Basilico N, Parapini S, Yardley V, et al. Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials. Journal of Medicinal Chemistry. 52: 502-13. PMID 19113955 DOI: 10.1021/Jm801352S |
0.394 |
|
| 2009 |
Bright SA, Greene LM, Greene TF, Campiani G, Butini S, Brindisi M, Lawler M, Meegan MJ, Williams DC, Zisterer DM. The novel pyrrolo-1,5-benzoxazepine, PBOX-21, potentiates the apoptotic efficacy of STI571 (imatinib mesylate) in human chronic myeloid leukaemia cells. Biochemical Pharmacology. 77: 310-21. PMID 19014913 DOI: 10.1016/J.Bcp.2008.10.008 |
0.354 |
|
| 2009 |
Gemma S, Martí F, Gabellieri E, Campiani G, Novellino E, Butini S. Synthetic studies toward 1,2-dioxanes as precursors of potential endoperoxide-containing antimalarials Tetrahedron Letters. 50: 5719-5722. DOI: 10.1016/J.Tetlet.2009.07.137 |
0.33 |
|
| 2008 |
Butini S, Gabellieri E, Huleatt PB, Campiani G, Franceschini S, Brindisi M, Ros S, Coccone SS, Fiorini I, Novellino E, Giorgi G, Gemma S. An efficient approach to chiral C8/C9-piperazino-substituted 1,4-benzodiazepin-2-ones as peptidomimetic scaffolds. The Journal of Organic Chemistry. 73: 8458-68. PMID 18844418 DOI: 10.1021/Jo8015456 |
0.328 |
|
| 2008 |
Butini S, Pickering DS, Morelli E, Coccone SS, Trotta F, Angelis MD, Guarino E, Fiorini I, Campiani G, Novellino E, Schousboe A, Christensen JK, Gemma S. 1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators. Journal of Medicinal Chemistry. 51: 6614-6618. PMID 18811139 DOI: 10.1021/Jm800865A |
0.346 |
|
| 2008 |
Butini S, Guarino E, Campiani G, Brindisi M, Coccone SS, Fiorini I, Novellino E, Belinskaya T, Saxena A, Gemma S. Tacrine based human cholinesterase inhibitors: synthesis of peptidic-tethered derivatives and their effect on potency and selectivity. Bioorganic & Medicinal Chemistry Letters. 18: 5213-6. PMID 18786825 DOI: 10.1016/J.Bmcl.2008.08.076 |
0.354 |
|
| 2008 |
Zanoli S, Gemma S, Butini S, Brindisi M, Joshi BP, Campiani G, Fattorusso C, Persico M, Crespan E, Cancio R, Spadari S, Hübscher U, Maga G. Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the ''primer grip'' region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants Biochemical Pharmacology. 76: 156-168. PMID 18541223 DOI: 10.1016/J.Bcp.2008.04.009 |
0.331 |
|
| 2008 |
Butini S, Campiani G, Borriello M, Gemma S, Panico A, Persico M, Catalanotti B, Ros S, Brindisi M, Agnusdei M, Fiorini I, Nacci V, Novellino E, Belinskaya T, Saxena A, et al. Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors. Journal of Medicinal Chemistry. 51: 3154-70. PMID 18479118 DOI: 10.1021/Jm701253T |
0.346 |
|
| 2008 |
Gemma S, Campiani G, Butini S, Kukreja G, Coccone SS, Joshi BP, Persico M, Nacci V, Fiorini I, Novellino E, Fattorusso E, Taglialatela-Scafati O, Savini L, Taramelli D, Basilico N, et al. Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies. Journal of Medicinal Chemistry. 51: 1278-94. PMID 18278860 DOI: 10.1021/Jm701247K |
0.404 |
|
| 2008 |
Fattorusso C, Campiani G, Kukreja G, Persico M, Butini S, Romano MP, Altarelli M, Ros S, Brindisi M, Savini L, Novellino E, Nacci V, Fattorusso E, Parapini S, Basilico N, et al. Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents. Journal of Medicinal Chemistry. 51: 1333-43. PMID 18278859 DOI: 10.1021/Jm7012375 |
0.408 |
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| 2008 |
Verma NK, Dempsey E, Conroy J, Olwell P, Mcelligott AM, Davies AM, Kelleher D, Butini S, Campiani G, Williams DC, Zisterer DM, Lawler M, Volkov Y. A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin. Journal of Molecular Medicine (Berlin, Germany). 86: 457-69. PMID 18270678 DOI: 10.1007/S00109-008-0312-8 |
0.323 |
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| 2008 |
Greene LM, Campiani G, Lawler M, Williams DC, Zisterer DM. BubR1 is required for a sustained mitotic spindle checkpoint arrest in human cancer cells treated with tubulin-targeting pyrrolo-1,5-benzoxazepines. Molecular Pharmacology. 73: 419-30. PMID 17991869 DOI: 10.1124/Mol.107.039024 |
0.32 |
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| 2007 |
Gemma S, Kukreja G, Campiani G, Butini S, Bernetti M, Joshi BP, Savini L, Basilico N, Taramelli D, Yardley V, Bertamino A, Novellino E, Persico M, Catalanotti B, Fattorusso C. Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling. Bioorganic & Medicinal Chemistry Letters. 17: 3535-3539. PMID 17493808 DOI: 10.1016/J.Bmcl.2007.04.077 |
0.36 |
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| 2007 |
Gemma S, Campiani G, Butini S, Kukreja G, Joshi BP, Persico M, Catalanotti B, Novellino E, Fattorusso E, Nacci V, Savini L, Taramelli D, Basilico N, Morace G, Yardley V, et al. Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: exploring an innovative pharmacophore. Journal of Medicinal Chemistry. 50: 595-8. PMID 17263523 DOI: 10.1021/Jm061429P |
0.398 |
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| 2007 |
Greene LM, Kelly L, Onnis V, Campiani G, Lawler M, Williams DC, Zisterer DM. STI-571 (imatinib mesylate) enhances the apoptotic efficacy of pyrrolo-1,5-benzoxazepine-6, a novel microtubule-targeting agent, in both STI-571-sensitive and -resistant Bcr-Abl-positive human chronic myeloid leukemia cells. The Journal of Pharmacology and Experimental Therapeutics. 321: 288-97. PMID 17202400 DOI: 10.1124/Jpet.106.116640 |
0.339 |
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| 2006 |
Fattorusso C, Campiani G, Catalanotti B, Persico M, Basilico N, Parapini S, Taramelli D, Campagnuolo C, Fattorusso E, Romano A, Taglialatela-Scafati O. Endoperoxide derivatives from marine organisms: 1,2-dioxanes of the plakortin family as novel antimalarial agents. Journal of Medicinal Chemistry. 49: 7088-7094. PMID 17125261 DOI: 10.1021/Jm060899G |
0.354 |
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| 2006 |
Gemma S, Kukreja G, Fattorusso C, Persico M, Romano MP, Altarelli M, Savini L, Campiani G, Fattorusso E, Basilico N, Taramelli D, Yardley V, Butini S. Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains. Bioorganic & Medicinal Chemistry Letters. 16: 5384-5388. PMID 16890433 DOI: 10.1016/J.Bmcl.2006.07.060 |
0.322 |
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| 2006 |
Gemma S, Gabellieri E, Huleatt P, Fattorusso C, Borriello M, Catalanotti B, Butini S, De Angelis M, Novellino E, Nacci V, Belinskaya T, Saxena A, Campiani G. Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites. Journal of Medicinal Chemistry. 49: 3421-5. PMID 16722663 DOI: 10.1021/Jm060257T |
0.363 |
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| 2006 |
Mulligan JM, Greene LM, Cloonan S, Mc Gee MM, Onnis V, Campiani G, Fattorusso C, Lawler M, Williams DC, Zisterer DM. Identification of tubulin as the molecular target of proapoptotic pyrrolo-1,5-benzoxazepines. Molecular Pharmacology. 70: 60-70. PMID 16571652 DOI: 10.1124/Mol.105.021204 |
0.409 |
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| 2005 |
Fattorusso C, Gemma S, Butini S, Huleatt P, Catalanotti B, Persico M, De Angelis M, Fiorini I, Nacci V, Ramunno A, Rodriquez M, Greco G, Novellino E, Bergamini A, Marini S, ... ... Campiani G, et al. Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity. Journal of Medicinal Chemistry. 48: 7153-65. PMID 16279773 DOI: 10.1021/Jm050257D |
0.361 |
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| 2005 |
Maga G, Gemma S, Fattorusso C, Locatelli GA, Butini S, Persico M, Kukreja G, Romano MP, Chiasserini L, Savini L, Novellino E, Nacci V, Spadari S, Campiani G. Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663. Biochemistry. 44: 9637-44. PMID 16008349 DOI: 10.1021/Bi047437U |
0.302 |
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| 2005 |
Mc Gee MM, Gemma S, Butini S, Ramunno A, Zisterer DM, Fattorusso C, Catalanotti B, Kukreja G, Fiorini I, Pisano C, Cucco C, Novellino E, Nacci V, Williams DC, Campiani G. Pyrrolo[1,5]benzoxa(thia)zepines as a new class of potent apoptotic agents. Biological studies and identification of an intracellular location of their drug target. Journal of Medicinal Chemistry. 48: 4367-77. PMID 15974589 DOI: 10.1021/Jm049402Y |
0.398 |
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| 2005 |
Ferlini C, Raspaglio G, Mozzetti S, Cicchillitti L, Filippetti F, Gallo D, Fattorusso C, Campiani G, Scambia G. The seco-taxane IDN5390 is able to target class III beta-tubulin and to overcome paclitaxel resistance. Cancer Research. 65: 2397-2405. PMID 15781655 DOI: 10.1158/0008-5472.Can-04-3065 |
0.304 |
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| 2005 |
Campiani G, Fattorusso C, Butini S, Gaeta A, Agnusdei M, Gemma S, Persico M, Catalanotti B, Savini L, Nacci V, Novellino E, Holloway HW, Greig NH, Belinskaya T, Fedorko JM, et al. Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors. Journal of Medicinal Chemistry. 48: 1919-29. PMID 15771436 DOI: 10.1021/Jm049510K |
0.355 |
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| 2005 |
Campiani G, Butini S, Fattorusso C, Trotta F, Gemma S, Catalanotti B, Nacci V, Fiorini I, Cagnotto A, Mereghetti I, Mennini T, Minetti P, Di Cesare MA, Stasi MA, Di Serio S, et al. Novel atypical antipsychotic agents: Rational design, an efficient palladium-catalyzed route, and pharmacological studies Journal of Medicinal Chemistry. 48: 1705-1708. PMID 15771414 DOI: 10.1021/Jm049629T |
0.341 |
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| 2005 |
Frandsen A, Pickering DS, Vestergaard B, Kasper C, Nielsen BB, Greenwood JR, Campiani G, Fattorusso C, Gajhede M, Schousboe A, Kastrup JS. Tyr702 is an important determinant of agonist binding and domain closure of the ligand-binding core of GluR2. Molecular Pharmacology. 67: 703-13. PMID 15591246 DOI: 10.1124/Mol.104.002931 |
0.314 |
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| 2005 |
Rogers A, Schmuck G, Scholz G, Griffiths R, Meredith C, Schousboe A, Campiani G, Williams DC. Improvements in an in-vitro assay for excitotoxicity by measurement of early gene (c-fos mRNA) levels. Archives of Toxicology. 79: 129-139. PMID 15565427 DOI: 10.1007/S00204-004-0617-5 |
0.328 |
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| 2005 |
Greene LM, Fleeton M, Mulligan J, Gowda C, Sheahan BJ, Atkins GJ, Campiani G, Nacci V, Lawler M, Williams DC, Zisterer DM. The pyrrolo-1,5-benzoxazepine, PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status and inhibits breast tumour growth in vivo. Oncology Reports. 14: 1357-1363. DOI: 10.3892/Or.14.5.1357 |
0.342 |
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| 2004 |
Lloyd DG, Hughes RB, Zisterer DM, Williams DC, Fattorusso C, Catalanotti B, Campiani G, Meegan MJ. Benzoxepin-derived estrogen receptor modulators: a novel molecular scaffold for the estrogen receptor. Journal of Medicinal Chemistry. 47: 5612-5. PMID 15509159 DOI: 10.1021/Jm0495834 |
0.317 |
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| 2004 |
Mc Gee MM, Greene LM, Ledwidge S, Campiani G, Nacci V, Lawler M, Williams DC, Zisterer DM. Selective induction of apoptosis by the pyrrolo-1,5-benzoxazepine 7-[[dimethylcarbamoyl]oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine (PBOX-6) in Leukemia cells occurs via the c-Jun NH2-terminal kinase-dependent phosphorylation and inactivation of Bcl-2 and Bcl-XL. The Journal of Pharmacology and Experimental Therapeutics. 310: 1084-95. PMID 15143129 DOI: 10.1124/Jpet.104.067561 |
0.323 |
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| 2004 |
Locatelli GA, Campiani G, Cancio R, Morelli E, Ramunno A, Gemma S, Hübscher U, Spadari S, Maga G. Effects of Drug Resistance Mutations L100I and V106A on the Binding of Pyrrolobenzoxazepinone Nonnucleoside Inhibitors to the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Catalytic Complex Antimicrobial Agents and Chemotherapy. 48: 1570-1580. PMID 15105107 DOI: 10.1128/Aac.48.5.1570-1580.2004 |
0.352 |
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| 2004 |
Campiani G, Butini S, Fattorusso C, Catalanotti B, Gemma S, Nacci V, Morelli E, Cagnotto A, Mereghetti I, Mennini T, Carli M, Minetti P, Di Cesare MA, Mastroianni D, Scafetta N, et al. Pyrrolo[1,3]benzothiazepine-Based Seroonin and Dopamine Receptor Antagonists. Molecular Modeling, Further Structure-Activity Relationship Studies, and Identification of Novel Atypical Antipsychotic Agents Journal of Medicinal Chemistry. 47: 143-157. PMID 14695828 DOI: 10.1021/Jm0309811 |
0.393 |
|
| 2003 |
Mennini T, Fumagalli E, Gobbi M, Fattorusso C, Catalanotti B, Campiani G. Substrate inhibitors and blockers of excitatory amino acid transporters in the treatment of neurodegeneration: Critical considerations European Journal of Pharmacology. 479: 291-296. PMID 14612159 DOI: 10.1016/J.Ejphar.2003.08.078 |
0.308 |
|
| 2003 |
Mulligan JM, Campiani G, Ramunno A, Nacci V, Zisterer DM. Inhibition of G1 cyclin-dependent kinase activity during growth arrest of human astrocytoma cells by the pyrrolo-1,5-benzoxazepine, PBOX-21. Biochimica Et Biophysica Acta. 1639: 43-52. PMID 12943967 DOI: 10.1016/S0925-4439(03)00128-5 |
0.303 |
|
| 2003 |
Campiani G, Butini S, Trotta F, Fattorusso C, Catalanotti B, Aiello F, Gemma S, Nacci V, Novellino E, Stark JA, Cagnotto A, Fumagalli E, Carnovali F, Cervo L, Mennini T. Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: Inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors Journal of Medicinal Chemistry. 46: 3822-3839. PMID 12930145 DOI: 10.1021/Jm0211220 |
0.334 |
|
| 2003 |
Sinclair C, Reavy H, Grieve A, Schousboe A, Morelli E, Novellino E, Campiani G, Griffiths R. Inherent desensitisation-preventing properties of a novel, subtype-selective AMPA receptor agonist, (S)-CPW 399, as a possible explanation for its excitotoxic action in cultured cerebellar granule cells. Neurochemistry International. 42: 499-510. PMID 12547649 DOI: 10.1016/S0197-0186(02)00141-9 |
0.323 |
|
| 2003 |
Savini L, Gaeta A, Fattorusso C, Catalanotti B, Campiani G, Chiasserini L, Pellerano C, Novellino E, McKissic D, Saxena A. Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors. Journal of Medicinal Chemistry. 46: 1-4. PMID 12502352 DOI: 10.1021/Jm0255668 |
0.35 |
|
| 2003 |
Butini S, Campiani G, Angelis MD, Fattorusso C, Nacci V, Fiorini I. Novel antipsychotic agents: recent advances in the drug treatment of schizophrenia Expert Opinion On Therapeutic Patents. 13: 425-448. DOI: 10.1517/13543776.13.4.425 |
0.311 |
|
| 2003 |
Gemma S, Butini S, Fattorusso C, Fiorini I, Nacci V, Bellebaum K, McKissic D, Saxena A, Campiani G. A palladium-catalyzed synthetic approach to new Huperzine A analogues modified at the pyridone ring Tetrahedron. 59: 87-93. DOI: 10.1016/S0040-4020(02)01449-7 |
0.312 |
|
| 2002 |
Campiani G, Ramunno A, Fiorini I, Nacci V, Morelli E, Novellino E, Goegan M, Mennini T, Sullivan S, Zisterer DM, Williams CD. Synthesis of new molecular probes for investigation of steroid biosynthesis induced by selective interaction with peripheral type benzodiazepine receptors (PBR). Journal of Medicinal Chemistry. 45: 4276-81. PMID 12213069 DOI: 10.1021/Jm020849L |
0.381 |
|
| 2002 |
Campiani G, Ramunno A, Maga G, Nacci V, Fattorusso C, Catalanotti B, Morelli E, Novellino E. Non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors: past, present, and future perspectives. Current Pharmaceutical Design. 8: 615-57. PMID 11945162 DOI: 10.2174/1381612024607207 |
0.353 |
|
| 2002 |
Mc Gee MM, Campiani G, Ramunno A, Nacci V, Lawler M, Williams DC, Zisterer DM. Activation of the c-Jun N-terminal kinase (JNK) signaling pathway is essential during PBOX-6-induced apoptosis in chronic myelogenous leukemia (CML) cells. The Journal of Biological Chemistry. 277: 18383-9. PMID 11856743 DOI: 10.1074/Jbc.M112058200 |
0.318 |
|
| 2002 |
Campiani G, Butini S, Gemma S, Nacci V, Fattorusso C, Catalanotti B, Giorgi G, Cagnotto A, Goegan M, Mennini T, Minetti P, Di Cesare MA, Mastroianni D, Scafetta N, Galletti B, et al. Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure - Activity relationship, molecular modeling, and biological studies Journal of Medicinal Chemistry. 45: 344-359. PMID 11784139 DOI: 10.1021/Jm010982Y |
0.358 |
|
| 2002 |
Gemma S, Campiani G, Butini S, Morelli E, Minetti P, Tinti O, Nacci V. Polycondensed heterocycles. Part 12: An approach to the synthesis of 2-acetyl-1′-methyl-1,2,3,4-tetrahydrospiro[isoquinoline-1,4′-pyrrolidine]-2′-one Tetrahedron. 58: 3689-3692. DOI: 10.1016/S0040-4020(02)00333-2 |
0.313 |
|
| 2001 |
Campiani G, Morelli E, Nacci V, Fattorusso C, Ramunno A, Novellino E, Greenwood J, Liljefors T, Griffiths R, Sinclair C, Reavy H, Kristensen AS, Pickering DS, Schousboe A, Cagnotto A, et al. Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties. Journal of Medicinal Chemistry. 44: 4501-4. PMID 11741469 DOI: 10.1021/Jm015552M |
0.355 |
|
| 2001 |
Zisterer DM, McGee MM, Campiani G, Ramunno A, Fattorusso C, Nacci V, Lawler M, Williams DC. Pyrrolo-1,5-benzoxazepines: a new class of apoptotic agents. Biochemical Society Transactions. 29: 704-6. PMID 11709059 DOI: 10.1042/0300-5127:0290704 |
0.368 |
|
| 2001 |
Maga G, Ramunno A, Nacci V, Locatelli GA, Spadari S, Fiorini I, Baldanti F, Paolucci S, Zavattoni M, Bergamini A, Galletti B, Muck S, Hubscher U, Giorgi G, Guiso G, ... ... Campiani G, et al. The stereoselective targeting of a specific enzyme-substrate complex is the molecular mechanism for the synergic inhibition of HIV-1 reverse transcriptase by (R)-(-)-PPO464: a novel generation of nonnucleoside inhibitors. The Journal of Biological Chemistry. 276: 44653-62. PMID 11572864 DOI: 10.1074/Jbc.M106702200 |
0.304 |
|
| 2001 |
Campiani G, De Angelis M, Armaroli S, Fattorusso C, Catalanotti B, Ramunno A, Nacci V, Novellino E, Grewer C, Ionescu D, Rauen T, Griffiths R, Sinclair C, Fumagalli E, Mennini T. A rational approach to the design of selective substrates and potent nontransportable inhibitors of the excitatory amino acid transporter EAAC1 (EAAT3). new glutamate and aspartate analogues as potential neuroprotective agents. Journal of Medicinal Chemistry. 44: 2507-10. PMID 11472204 DOI: 10.1021/Jm015509Z |
0.369 |
|
| 2001 |
Savini L, Campiani G, Gaeta A, Pellerano C, Fattorusso C, Chiasserini L, Fedorko JM, Saxena A. Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase Bioorganic & Medicinal Chemistry Letters. 11: 1779-1782. PMID 11425559 DOI: 10.1016/S0960-894X(01)00294-3 |
0.366 |
|
| 1999 |
Campiani G, Morelli E, Fabbrini M, Nacci V, Greco G, Novellino E, Ramunno A, Maga G, Spadari S, Caliendo G, Bergamini A, Faggioli E, Uccella I, Bolacchi F, Marini S, et al. Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity. Journal of Medicinal Chemistry. 42: 4462-70. PMID 10543890 DOI: 10.1021/Jm990150O |
0.409 |
|
| 1999 |
Campiani G, Morelli E, Gemma S, Nacci V, Butini S, Hamon M, Novellino E, Greco G, Cagnotto A, Goegan M, Cervo L, Dalla Valle F, Fracasso C, Caccia S, Mennini T. Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies. Journal of Medicinal Chemistry. 42: 4362-79. PMID 10543880 DOI: 10.1021/Jm990151G |
0.347 |
|
| 1999 |
Neamati N, Turpin JA, Winslow HE, Christensen JL, Williamson K, Orr A, Rice WG, Pommier Y, Garofalo A, Brizzi A, Campiani G, Fiorini I, Nacci V. Thiazolothiazepine inhibitors of HIV-1 integrase. Journal of Medicinal Chemistry. 42: 3334-41. PMID 10464020 DOI: 10.1021/Jm990047Z |
0.363 |
|
| 1999 |
Campiani G, Kozikowski AP, Wang S, Ming L, Nacci V, Saxena A, Doctor BP. Synthesis and anticholinesterase activity of huperzine A analogues containing phenol and catechol replacements for the pyridone ring. Bioorganic & Medicinal Chemistry Letters. 8: 1413-8. PMID 9871776 DOI: 10.1016/S0960-894X(98)00229-7 |
0.355 |
|
| 1999 |
Garofalo A, Campiani G, Fiorini I, Nacci V. Polycondensed heterocycles. X. A new method for the preparation of pyrrolo[2,1-c][1,4]benzothiazepines by intramolecular mitsunobu cyclisation Tetrahedron. 55: 1479-1490. DOI: 10.1016/S0040-4020(98)01127-2 |
0.309 |
|
| 1998 |
Campiani G, Nacci V, Bechelli S, Ciani SM, Garofalo A, Fiorini I, Wikström H, de Boer P, Liao Y, Tepper PG, Cagnotto A, Mennini T. New antipsychotic agents with serotonin and dopamine antagonist properties based on a pyrrolo[2,1-b][1,3]benzothiazepine structure. Journal of Medicinal Chemistry. 41: 3763-72. PMID 9748351 DOI: 10.1021/Jm9706832 |
0.335 |
|
| 1998 |
Zisterer DM, Hance N, Campiani G, Garofalo A, Nacci V, Williams DC. Antiproliferative action of pyrrolobenzoxazepine derivatives in cultured cells: absence of correlation with binding to the peripheral-type benzodiazepine binding site. Biochemical Pharmacology. 55: 397-403. PMID 9514073 DOI: 10.1016/S0006-2952(97)00500-5 |
0.308 |
|
| 1997 |
Campiani G, Cappelli A, Nacci V, Anzini M, Vomero S, Hamon M, Cagnotto A, Fracasso C, Uboldi C, Caccia S, Consolo S, Mennini T. Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure. Journal of Medicinal Chemistry. 40: 3670-8. PMID 9357534 DOI: 10.1021/Jm970376W |
0.356 |
|
| 1997 |
Corelli F, Manetti F, Tafi A, Campiani G, Nacci V, Botta M. Diltiazem-like calcium entry blockers: a hypothesis of the receptor-binding site based on a comparative molecular field analysis model. Journal of Medicinal Chemistry. 40: 125-31. PMID 9016337 DOI: 10.1021/Jm9605647 |
0.351 |
|
| 1997 |
Campiani G, Nacci V, Fiorini I, Filippis MD, Garofalo A, Ciani S, Greco G, Novellino E, Manzoni C, Mennini T. New pyrrolobenzothiazepine derivatives as molecular probes of the ‘peripheral-type’ benzodiazepine receptor (PBR) binding site European Journal of Medicinal Chemistry. 32: 241-251. DOI: 10.1016/S0223-5234(97)83975-X |
0.352 |
|
| 1996 |
Campiani G, Nacci V, Fiorini I, De Filippis MP, Garofalo A, Ciani SM, Greco G, Novellino E, Williams DC, Zisterer DM, Woods MJ, Mihai C, Manzoni C, Mennini T. Synthesis, biological activity, and SARs of pyrrolobenzoxazepine derivatives, a new class of specific "peripheral-type" benzodiazepine receptor ligands. Journal of Medicinal Chemistry. 39: 3435-50. PMID 8784441 DOI: 10.1021/Jm960251B |
0.35 |
|
| 1996 |
Campiani G, Fiorini I, De Filippis MP, Ciani SM, Garofalo A, Nacci V, Giorgi G, Sega A, Botta M, Chiarini A, Budriesi R, Bruni G, Romeo MR, Manzoni C, Mennini T. Cardiovascular characterization of pyrrolo[2,1-d][1,5]benzothiazepine derivatives binding selectively to the peripheral-type benzodiazepine receptor (PBR): from dual PBR affinity and calcium antagonist activity to novel and selective calcium entry blockers. Journal of Medicinal Chemistry. 39: 2922-38. PMID 8709127 DOI: 10.1021/Jm960162Z |
0.356 |
|
| 1996 |
Campiani G, Nacci V, Fiorini I, De Filippis MP, Garofalo A, Greco G, Novellino E, Altamura S, Di Renzo L. Pyrrolobenzothiazepinones and pyrrolobenzoxazepinones: novel and specific non-nucleoside HIV-1 reverse transcriptase inhibitors with antiviral activity. Journal of Medicinal Chemistry. 39: 2672-80. PMID 8709096 DOI: 10.1021/Jm950702C |
0.344 |
|
| 1996 |
Kozikowski AP, Campiani G, Nacci V, Sega A, Saxena A, Doctor BP. An approach to modified heterocyclic analogues of huperzine A and isohuperzine A. Synthesis of the pyrimidone and pyrazole analogues, and their anticholinesterase activity Journal of the Chemical Society-Perkin Transactions 1. 1287-1297. DOI: 10.1039/P19960001287 |
0.351 |
|
| 1996 |
Kozikowski AP, Campiani G, Sun §L, Wang S, Saxena aA, Doctor BP. Identification of a more potent analogue of the naturally occurring alkaloid huperzine A. Predictive molecular modeling of its interaction with AChE Journal of the American Chemical Society. 118: 11357-11362. DOI: 10.1021/Ja9622822 |
0.385 |
|
| 1995 |
Dalpiaz A, Bertolasi V, Borea PA, Nacci V, Fiorini I, Campiani G, Mennini T, Manzoni C, Novellino E, Greco G. A concerted study using binding measurements, X-ray structural data, and molecular modeling on the stereochemical features responsible for the affinity of 6-arylpyrrolo[2,1-d][1,5]benzothiazepines toward mitochondrial benzodiazepine receptors. Journal of Medicinal Chemistry. 38: 4730-8. PMID 7473601 DOI: 10.1021/Jm00023A013 |
0.306 |
|
| 1995 |
Campiani G, Garofalo A, Fiorini I, Botta M, Nacci V, Tafi A, Chiarini A, Budriesi R, Bruni G, Romeo MR. Pyrrolo[2,1-c][1,4]benzothiazines: synthesis, structure-activity relationships, molecular modeling studies, and cardiovascular activity. Journal of Medicinal Chemistry. 38: 4393-410. PMID 7473567 DOI: 10.1021/Jm00022A005 |
0.38 |
|
| 1995 |
Kozikowski AP, Campiani G, Saxena A, Doctor BP. Synthesis and acetylcholinesterase inhibitory activity of several pyrimidone analogues of huperzine A Journal of the Chemical Society, Chemical Communications. 283-285. DOI: 10.1039/C39950000283 |
0.37 |
|
| 1994 |
Fiorini I, Nacci V, Ciani SM, Garofalo A, Campiani G, Savini L, Novellino E, Greco G, Bernasconi P, Mennini T. Novel ligands specific for mitochondrial benzodiazepine receptors: 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives. Synthesis, structure-activity relationships, and molecular modeling studies. Journal of Medicinal Chemistry. 37: 1427-38. PMID 8182701 DOI: 10.1021/Jm00036A007 |
0.394 |
|
| 1994 |
Greco G, Novellino E, Fiorini I, Nacci V, Campiani G, Ciani SM, Garofalo A, Bernasconi P, Mennini T. A comparative molecular field analysis model for 6-arylpyrrolo[2,1-d] [1,5]benzothiazepines binding selectively to the mitochondrial benzodiazepine receptor. Journal of Medicinal Chemistry. 37: 4100-8. PMID 7990110 DOI: 10.1021/Jm00050A007 |
0.32 |
|
| 1994 |
Campiani G, Garofalo A, Fiorini I, Nacci V, Botta M, Tafi A, Chiarini A, Budriesi R, Bruni G, Romeo M. Synthesis and “in vitro” cardiovascular activity of 4-aryl-2,3,3a,4-tetrahydro-1h-pyrrolo[2,1-c][1,4]benzothiazin-1-ones and 7-acetoxy-6-phenyl-7a,8,9,10-tetrahydropyrrolo [2,1,-d][1,5]benzothiazepin-10-one. Bioorganic & Medicinal Chemistry Letters. 4: 1235-1240. DOI: 10.1016/S0960-894X(01)80337-1 |
0.325 |
|
| 1992 |
Campiani G, Nacci V, Garofalo A, Botta M, Fiorini I, Tafi A, Bruni G, Romeo M, Peres A, Bertollini L. Synthesis and preliminary biological evaluation of 1-aminomethyl-4-substituted-4-H-pyrrolo[2,1-C][1,4] benzothiazines, a new class of calcium antagonists. Bioorganic & Medicinal Chemistry Letters. 2: 1193-1198. DOI: 10.1016/S0960-894X(00)80212-7 |
0.311 |
|
| 1990 |
Nacci V, Campiani G, Garofalo A. Polycondensed Heterocycles.VI. A new efficient synthesis of 4H-pyrrolo [2,1-c][1, 4] Benzothiazines Synthetic Communications. 20: 3019-3029. DOI: 10.1080/00397919008051521 |
0.302 |
|
| 1990 |
Nacci V, Campiani G, Garofalo A. Polycondensed heterocycles. IV. synthesis of 1,4-dioxo-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzothiazine† Journal of Heterocyclic Chemistry. 27: 1329-1335. DOI: 10.1002/Jhet.5570270528 |
0.313 |
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