| Year | Citation | Score | |||
|---|---|---|---|---|---|
| 2019 | Scanio MJC, Searle XB, Liu B, Koenig JR, Altenbach R, Gfesser GA, Bogdan A, Greszler S, Zhao G, Singh A, Fan Y, Swensen AM, Vortherms T, Manelli A, Balut C, et al. Discovery of ABBV/GLPG-3221, a Potent Corrector of CFTR for the Treatment of Cystic Fibrosis. Acs Medicinal Chemistry Letters. 10: 1543-1548. PMID 31749908 DOI: 10.1021/Acsmedchemlett.9B00377 | 0.334 | |||
| 2019 | Singh AK, Fan Y, Balut C, Alani S, Manelli A, Swensen AM, Jia Y, Neelands TR, Vortherms TA, Liu B, Searle XB, Wang X, Gao W, Hwang TC, Ren H, et al. Biological characterization of F508delCFTR protein processing by the CFTR Corrector ABBV-2222/GLPG2222. The Journal of Pharmacology and Experimental Therapeutics. PMID 31732698 DOI: 10.1124/Jpet.119.261800 | 0.328 | |||
| 2017 | Wang X, Liu B, Searle X, Yeung C, Bogdan AR, Greszler SN, Singh A, Fan Y, Swensen AM, Vortherms T, Balut C, Jia Y, Desino KE, Gao W, Yong H, et al. Discovery of 4-[(2R,4R)-4-({[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis. Journal of Medicinal Chemistry. PMID 29251932 DOI: 10.1021/Acs.Jmedchem.7B01339 | 0.334 | |||
| 2014 | Zhu CZ, Vortherms TA, Zhang M, Xu J, Swensen AM, Niforatos W, Neelands T, Milicic I, Lewis LG, Zhong C, Gauvin D, Mikusa J, Zhan C, Pai M, Roderwald V, ... ... Searle XB, et al. Mechanistic insights into the analgesic efficacy of A-1264087, a novel neuronal Ca(2+) channel blocker that reduces nociception in rat preclinical pain models. The Journal of Pain : Official Journal of the American Pain Society. 15: 387.e1-14. PMID 24374196 DOI: 10.1016/J.Jpain.2013.12.002 | 0.332 | |||
| 2014 | Xu J, Chu KL, Zhu CZ, Niforatos W, Swensen A, Searle X, Lee L, Jarvis MF, McGaraughty S. A mixed Ca2+ channel blocker, A-1264087, utilizes peripheral and spinal mechanisms to inhibit spinal nociceptive transmission in a rat model of neuropathic pain. Journal of Neurophysiology. 111: 394-404. PMID 24155005 DOI: 10.1152/Jn.00463.2013 | 0.312 | |||
| 2007 | Bunnelle WH, Daanen JF, Ryther KB, Schrimpf MR, Dart MJ, Gelain A, Meyer MD, Frost JM, Anderson DJ, Buckley M, Curzon P, Cao YJ, Puttfarcken P, Searle X, Ji J, et al. Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors. Journal of Medicinal Chemistry. 50: 3627-44. PMID 17585748 DOI: 10.1021/Jm070018L | 0.335 | |||
| 2004 | Altenbach RJ, Khilevich A, Kolasa T, Rohde JJ, Bhatia PA, Patel MV, Searle XB, Yang F, Bunnelle WH, Tietje K, Bayburt EK, Carroll WA, Meyer MD, Henry R, Buckner SA, et al. Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. Journal of Medicinal Chemistry. 47: 3220-35. PMID 15163201 DOI: 10.1021/Jm030551A | 0.313 | |||
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