Derek S. Steele, BSc, PhD - Publications

Affiliations: 
University of Leeds, Leeds, England, United Kingdom 

74 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Hurley ME, Shah SS, Sheard TMD, Kirton HM, Steele DS, Gamper N, Jayasinghe I. Super-Resolution Analysis of the Origins of the Elementary Events of ER Calcium Release in Dorsal Root Ganglion Neurons. Cells. 13. PMID 38201242 DOI: 10.3390/cells13010038  0.457
2023 Steer EJ, Yang Z, Al-Owais MM, Kirton HM, White E, Steele DS. Flecainide induces a sustained countercurrent dependent effect on RyR2 in permeabilized WT ventricular myocytes but not in intact cells. Frontiers in Pharmacology. 14: 1155601. PMID 37124209 DOI: 10.3389/fphar.2023.1155601  0.492
2020 Hurley ME, Sheard TMD, Norman R, Kirton HM, Shah SS, Pervolaraki E, Yang Z, Gamper N, White E, Steele D, Jayasinghe I. A correlative super-resolution protocol to visualise structural underpinnings of fast second-messenger signalling in primary cell types. Methods (San Diego, Calif.). PMID 33059034 DOI: 10.1016/j.ymeth.2020.10.005  0.382
2020 Tsai YM, Jones F, Mullen P, Porter KE, Steele D, Peers C, Gamper N. Vascular Kv7 channels control intracellular Ca dynamics in smooth muscle. Cell Calcium. 92: 102283. PMID 32950876 DOI: 10.1016/J.Ceca.2020.102283  0.536
2020 Steer EJ, Yang Z, Steele DS. Low RyR2 Sensitivity to Flecainide Combined with Slow Sarcolemmal Entry and Rapid Mitochondrial Accumulation May Explain the Absence of RyR2 Effects Intact Wild Type Myocytes Biophysical Journal. 118: 563a. DOI: 10.1016/J.Bpj.2019.11.3073  0.301
2019 Lotteau S, Ivarsson N, Yang Z, Restagno D, Colyer J, Hopkins P, Weightman A, Himori K, Yamada T, Bruton J, Steele D, Westerblad H, Calaghan S. A Mechanism for Statin-Induced Susceptibility to Myopathy. Jacc: Basic to Translational Science. 4: 509-523. PMID 31468006 DOI: 10.1016/J.Jacbts.2019.03.012  0.537
2019 Fowler ED, Hauton D, Boyle J, Egginton S, Steele DS, White E. Energy Metabolism in the Failing Right Ventricle: Limitations of Oxygen Delivery and the Creatine Kinase System. International Journal of Molecular Sciences. 20. PMID 31013688 DOI: 10.3390/Ijms20081805  0.324
2018 Fowler ED, Drinkhill MJ, Norman R, Pervolaraki E, Stones R, Steer E, Benoist D, Steele DS, Calaghan SC, White E. Beta1-adrenoceptor antagonist, metoprolol attenuates cardiac myocyte Ca handling dysfunction in rats with pulmonary artery hypertension. Journal of Molecular and Cellular Cardiology. 120: 74-83. PMID 29807024 DOI: 10.1016/J.Yjmcc.2018.05.015  0.473
2017 Venturi E, Lindsay C, Lotteau S, Yang Z, Steer E, Witschas K, Wilson AD, Wickens JR, Russell AJ, Steele D, Calaghan S, Sitsapesan R. Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform. British Journal of Pharmacology. PMID 29278865 DOI: 10.1111/Bph.14136  0.444
2017 Al-Owais MM, Hettiarachchi NT, Boyle JP, Scragg JL, Elies J, Dallas ML, Lippiat JD, Steele DS, Peers C. Multiple mechanisms mediating carbon monoxide inhibition of the voltage-gated K(+) channel Kv1.5. Cell Death & Disease. 8: e3163. PMID 29095440 DOI: 10.1038/Cddis.2017.568  0.394
2017 Al-Owais MM, Hettiarachchi NT, Kirton HM, Hardy ME, Boyle JP, Scragg JL, Steele DS, Peers C. A key role for peroxynitrite-mediated inhibition of cardiac ERG (Kv11.1) K(+) channels in carbon monoxide-induced proarrhythmic early afterdepolarizations. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28743763 DOI: 10.1096/Fj.201700259R  0.327
2016 Kirton HM, Yang Z, Steele DS. Conditions that Promote Golgi Ca2+ Release Facilitate Trafficking of VEGFR-1 to the Surface Membrane in Rat Ventricular Myocytes Biophysical Journal. 110: 436a. DOI: 10.1016/J.Bpj.2015.11.2350  0.498
2016 Lotteau S, Yang Z, Venturi E, Steer E, Witschas K, Sitsapesan R, Steele D, Calaghan S. Simvastatin has Profound Effects on Sarcoplasmic Reticulum Ca2+ Leak in Skeletal but not Cardiac Muscle: A Mechanism for Myopathy Biophysical Journal. 110: 266a. DOI: 10.1016/J.Bpj.2015.11.1453  0.557
2016 Venturi E, Witschas K, Lotteau SJ, Steer E, Steele DS, Calaghan SC, Sitsapesan R. Simvastatin Activates Single Skeletal RyR1 Channels but Exerts More Complex Regulation of the Cardiac Isoform, RyR2 Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.1452  0.496
2015 Yang Z, Kirton HM, MacDougall DA, Boyle JP, Deuchars J, Frater B, Ponnambalam S, Hardy ME, White E, Calaghan SC, Peers C, Steele DS. The Golgi apparatus is a functionally distinct Ca2+ store regulated by the PKA and Epac branches of the β1-adrenergic signaling pathway. Science Signaling. 8: ra101. PMID 26462734 DOI: 10.1126/Scisignal.Aaa7677  0.584
2015 Fowler ED, Benoist D, Drinkhill MJ, Stones R, Helmes M, Wüst RC, Stienen GJ, Steele DS, White E. Decreased creatine kinase is linked to diastolic dysfunction in rats with right heart failure induced by pulmonary artery hypertension. Journal of Molecular and Cellular Cardiology. 86: 1-8. PMID 26116865 DOI: 10.1016/J.Yjmcc.2015.06.016  0.37
2015 Peers C, Boyle JP, Scragg JL, Dallas ML, Al-Owais MM, Hettiarachichi NT, Elies J, Johnson E, Gamper N, Steele DS. Diverse mechanisms underlying the regulation of ion channels by carbon monoxide. British Journal of Pharmacology. 172: 1546-56. PMID 24818840 DOI: 10.1111/Bph.12760  0.323
2015 Lotteau S, MacDougall D, Steele D, Calaghan S. Statin Induced Myopathy: A Role for Mitochondrial Ca2+ and No in Enhanced Sarcoplasmic Reticulum Ca2+ Leak Biophysical Journal. 108: 567a. DOI: 10.1016/J.Bpj.2014.11.3106  0.592
2015 Fowler ED, Drinkhill MJ, Wust RC, Helmes M, Stienen GJ, Steele DS, White E. Workloop Contractions in Isolated Cardiac Myocytes Reflect in vivo Pressure-Volume Dysfunction in Rat Right Heart Failure Biophysical Journal. 108: 294a. DOI: 10.1016/J.Bpj.2014.11.1600  0.346
2015 Kirton HM, Yang Z, Steele DS. Phosphodiesterase Inhibition Leads to Activation of Epac and Stimulation of Ca2+ Release from both the Golgi Apparatus and the SR Biophysical Journal. 108: 263a. DOI: 10.1016/J.Bpj.2014.11.1452  0.571
2014 Steele EM, Steele DS. Automated detection and analysis of Ca(2+) sparks in x-y image stacks using a thresholding algorithm implemented within the open-source image analysis platform ImageJ. Biophysical Journal. 106: 566-76. PMID 24507597 DOI: 10.1016/J.Bpj.2013.12.040  0.403
2014 Kirton HM, Hardy M, White E, Steele D. Bin-1 Expression in Normal Rat Cardiac Myocytes and in Myocytes with Reduced T-Tubule Density Due to Cell Culture or Heart Failure Biophysical Journal. 106: 772a. DOI: 10.1016/J.Bpj.2013.11.4239  0.312
2013 Steele DS, Hwang HS, Knollmann BC. Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia. Cardiovascular Research. 98: 326-7. PMID 23512981 DOI: 10.1093/Cvr/Cvt059  0.604
2012 Dallas ML, Yang Z, Boyle JP, Boycott HE, Scragg JL, Milligan CJ, Elies J, Duke A, Thireau J, Reboul C, Richard S, Bernus O, Steele DS, Peers C. Carbon monoxide induces cardiac arrhythmia via induction of the late Na+ current. American Journal of Respiratory and Critical Care Medicine. 186: 648-56. PMID 22822026 DOI: 10.1164/Rccm.201204-0688Oc  0.433
2012 Benoist D, Stones R, Drinkhill MJ, Benson AP, Yang Z, Cassan C, Gilbert SH, Saint DA, Cazorla O, Steele DS, Bernus O, White E. Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension. American Journal of Physiology. Heart and Circulatory Physiology. 302: H2381-95. PMID 22427523 DOI: 10.1152/Ajpheart.01084.2011  0.498
2012 Peers C, Steele DS. Carbon monoxide: a vital signalling molecule and potent toxin in the myocardium. Journal of Molecular and Cellular Cardiology. 52: 359-65. PMID 21640728 DOI: 10.1016/J.Yjmcc.2011.05.013  0.356
2012 Steele D, Yang Z. Ranolazine Alters the Properties of Localized Ca2+ Sparks and Inhibits Global Ca2+ Waves in Rat Myocytes Biophysical Journal. 102: 510a. DOI: 10.1016/J.Bpj.2011.11.2792  0.57
2011 Watanabe H, Steele DS, Knollmann BC. Mechanism of antiarrhythmic effects of flecainide in catecholaminergic polymorphic ventricular tachycardia. Circulation Research. 109: 712-3. PMID 21885838 DOI: 10.1161/Circresaha.111.251322  0.457
2011 Yang Z, Steele DS. The Golgi Apparatus is a Juxtanuclear Ca2+ Store Regulated by β1-Adrenergic Signalling via Both PKA and EPAC Pathways Biophysical Journal. 100: 352a. DOI: 10.1016/J.Bpj.2010.12.2118  0.56
2010 Duke AM, Hopkins PM, Calaghan SC, Halsall JP, Steele DS. Store-operated Ca2+ entry in malignant hyperthermia-susceptible human skeletal muscle. The Journal of Biological Chemistry. 285: 25645-53. PMID 20566647 DOI: 10.1074/Jbc.M110.104976  0.597
2010 Duncan DJ, Yang Z, Hopkins PM, Steele DS, Harrison SM. TNF-alpha and IL-1beta increase Ca2+ leak from the sarcoplasmic reticulum and susceptibility to arrhythmia in rat ventricular myocytes. Cell Calcium. 47: 378-86. PMID 20227109 DOI: 10.1016/J.Ceca.2010.02.002  0.695
2010 Hilliard FA, Steele DS, Laver D, Yang Z, Le Marchand SJ, Chopra N, Piston DW, Huke S, Knollmann BC. Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass. Journal of Molecular and Cellular Cardiology. 48: 293-301. PMID 19835880 DOI: 10.1016/J.Yjmcc.2009.10.005  0.609
2010 Duke AM, Hopkins PM, Halsal JP, Steele DS. Properties of Store Operated Ca2+ Entry in Malignant Hyperthermia Susceptible Human Skeletal Muscle Fibres Biophysical Journal. 98: 711a-712a. DOI: 10.1016/J.Bpj.2009.12.3903  0.594
2009 Pickering JD, White E, Duke AM, Steele DS. DHPR activation underlies SR Ca2+ release induced by osmotic stress in isolated rat skeletal muscle fibers. The Journal of General Physiology. 133: 511-24. PMID 19398777 DOI: 10.1085/Jgp.200910191  0.585
2009 Amer MS, Li J, O'Regan DJ, Steele DS, Porter KE, Sivaprasadarao A, Beech DJ. Translocon closure to Ca2+ leak in proliferating vascular smooth muscle cells. American Journal of Physiology. Heart and Circulatory Physiology. 296: H910-6. PMID 19218505 DOI: 10.1152/Ajpheart.00984.2008  0.341
2009 Pickering JD, White E, Steele D. DHPR Activation Is A Prerequisite For SR Ca2+ Release Induced By Increased Osmolarity In Isolated Rat Skeletal Muscle Fibres Biophysical Journal. 96. DOI: 10.1016/J.Bpj.2008.12.1151  0.525
2008 Duke AM, Steele DS. The presence of a functional t-tubule network increases the sensitivity of RyR1 to agonists in skinned rat skeletal muscle fibres. Cell Calcium. 44: 411-21. PMID 19230144 DOI: 10.1016/J.Ceca.2008.02.006  0.49
2007 George CH, Rogers SA, Bertrand BM, Tunwell RE, Thomas NL, Steele DS, Cox EV, Pepper C, Hazeel CJ, Claycomb WC, Lai FA. Alternative splicing of ryanodine receptors modulates cardiomyocyte Ca2+ signaling and susceptibility to apoptosis. Circulation Research. 100: 874-83. PMID 17322175 DOI: 10.1161/01.Res.0000260804.77807.Cf  0.561
2007 Steele DS, Duke AM. Defective Mg2+ regulation of RyR1 as a causal factor in malignant hyperthermia. Archives of Biochemistry and Biophysics. 458: 57-64. PMID 16620769 DOI: 10.1016/J.Abb.2006.03.001  0.546
2006 Duke AM, Hopkins PM, Halsall PJ, Steele DS. Mg2+ dependence of Ca2+ release from the sarcoplasmic reticulum induced by sevoflurane or halothane in skeletal muscle from humans susceptible to malignant hyperthermia. British Journal of Anaesthesia. 97: 320-8. PMID 16849381 DOI: 10.1093/Bja/Ael179  0.535
2006 Yang Z, Ikemoto N, Lamb GD, Steele DS. The RyR2 central domain peptide DPc10 lowers the threshold for spontaneous Ca2+ release in permeabilized cardiomyocytes. Cardiovascular Research. 70: 475-85. PMID 16624262 DOI: 10.1016/J.Cardiores.2006.03.001  0.366
2006 Yang Z, Ikemoto N, Lamb GD, Steele DS. Corrigendum to: The RyR2 central domain peptide DPc10 lowers the threshold for spontaneous Ca2+ release in permeabilized cardiomyocytes [Cardiovascular Research 70 (2006) 475-485] (DOI:10.1016/j.cardiores.2006.03.001) Cardiovascular Research. 71: 606. DOI: 10.1016/J.Cardiores.2006.06.009  0.445
2005 Yang Z, Harrison SM, Steele DS. ATP-dependent effects of halothane on SR Ca2+ regulation in permeabilized atrial myocytes. Cardiovascular Research. 65: 167-76. PMID 15621044 DOI: 10.1016/J.Cardiores.2004.09.008  0.716
2005 Yang Z, Steele DS. Characteristics of prolonged Ca2+ release events associated with the nuclei in adult cardiac myocytes. Circulation Research. 96: 82-90. PMID 15569829 DOI: 10.1161/01.Res.0000151841.63705.01  0.606
2004 Duke AM, Hopkins PM, Halsal JP, Steele DS. Mg2+ dependence of halothane-induced Ca2+ release from the sarcoplasmic reticulum in skeletal muscle from humans susceptible to malignant hyperthermia. Anesthesiology. 101: 1339-46. PMID 15564941 DOI: 10.1097/00000542-200412000-00014  0.507
2003 Steele DS, Duke AM. Metabolic factors contributing to altered Ca2+ regulation in skeletal muscle fatigue. Acta Physiologica Scandinavica. 179: 39-48. PMID 12940937 DOI: 10.1046/j.1365-201X.2003.01169.x  0.518
2003 Duke AM, Hopkins PM, Steele DS. Mg2+ dependence of halothane-induced Ca2+ release from the sarcoplasmic reticulum in rat skeletal muscle. The Journal of Physiology. 551: 447-54. PMID 12909676 DOI: 10.1113/Jphysiol.2003.046623  0.571
2002 Duke AM, Hopkins PM, Steele DS. Effects of Mg(2+) and SR luminal Ca(2+) on caffeine-induced Ca(2+) release in skeletal muscle from humans susceptible to malignant hyperthermia. The Journal of Physiology. 544: 85-95. PMID 12356882 DOI: 10.1113/Jphysiol.2002.022749  0.59
2002 Yang Z, Pascarel C, Steele DS, Komukai K, Brette F, Orchard CH. Na+-Ca2+ exchange activity is localized in the T-tubules of rat ventricular myocytes. Circulation Research. 91: 315-22. PMID 12193464 DOI: 10.1161/01.Res.0000030180.06028.23  0.605
2002 Yang Z, Steele DS. Effects of phosphocreatine on SR Ca(2+) regulation in isolated saponin-permeabilized rat cardiac myocytes. The Journal of Physiology. 539: 767-77. PMID 11897848 DOI: 10.1113/Jphysiol.2001.012987  0.623
2001 Yang Z, Steele DS. Effects of cytosolic ATP on Ca(2+) sparks and SR Ca(2+) content in permeabilized cardiac myocytes. Circulation Research. 89: 526-33. PMID 11557740 DOI: 10.1161/Hh1801.096264  0.592
2001 Duke AM, Steele DS. Mechanisms of reduced SR Ca(2+) release induced by inorganic phosphate in rat skeletal muscle fibers. American Journal of Physiology. Cell Physiology. 281: C418-29. PMID 11443041 DOI: 10.1152/Ajpcell.2001.281.2.C418  0.574
2001 Darnley GM, Duke AM, Steele DS, MacFarlane NG. Effects of reactive oxygen species on aspects of excitation-contraction coupling in chemically skinned rabbit diaphragm muscle fibres. Experimental Physiology. 86: 161-8. PMID 11429630 DOI: 10.1113/Eph8602109  0.753
2001 Duke AM, Steele DS. Interdependent effects of inorganic phosphate and creatine phosphate on sarcoplasmic reticulum Ca2+ regulation in mechanically skinned rat skeletal muscle. The Journal of Physiology. 531: 729-42. PMID 11251054 DOI: 10.1111/J.1469-7793.2001.0729H.X  0.621
2000 Yang Z, Steele DS. Effects of cytosolic ATP on spontaneous and triggered Ca2+-induced Ca2+ release in permeabilised rat ventricular myocytes. The Journal of Physiology. 523: 29-44. PMID 10673543 DOI: 10.1111/J.1469-7793.2000.00029.X  0.614
2000 Duke AM, Steele DS. Characteristics of phosphate-induced Ca(2+) efflux from the SR in mechanically skinned rat skeletal muscle fibers. American Journal of Physiology. Cell Physiology. 278: C126-35. PMID 10644520 DOI: 10.1152/Ajpcell.2000.278.1.C126  0.623
1999 Duke AM, Steele DS. Effects of creatine phosphate on Ca2+ regulation by the sarcoplasmic reticulum in mechanically skinned rat skeletal muscle fibres. The Journal of Physiology. 517: 447-58. PMID 10332094 DOI: 10.1111/J.1469-7793.1999.0447T.X  0.63
1998 Smith GL, Steele DS. Measurement of SR Ca2+ content in the presence of caffeine in permeabilised rat cardiac trabeculae. PflüGers Archiv : European Journal of Physiology. 437: 139-48. PMID 9817798 DOI: 10.1007/S004240050758  0.708
1998 Duke AM, Steele DS. Effects of caffeine and adenine nucleotides on Ca2+ release by the sarcoplasmic reticulum in saponin-permeabilized frog skeletal muscle fibres. The Journal of Physiology. 513: 43-53. PMID 9782158 DOI: 10.1111/J.1469-7793.1998.043By.X  0.598
1998 Duke AM, Steele DS. Effects of cyclopiazonic acid on Ca2+ regulation by the sarcoplasmic reticulum in saponin-permeabilized skeletal muscle fibres. PflüGers Archiv : European Journal of Physiology. 436: 104-11. PMID 9560453 DOI: 10.1007/S004240050610  0.622
1998 Orchard CH, Smith GL, Steele DS. Effects of cytosolic Ca2+ on the Ca2+ content of the sarcoplasmic reticulum in saponin-permeabilized rat ventricular trabeculae. PflüGers Archiv : European Journal of Physiology. 435: 555-63. PMID 9446704 DOI: 10.1007/S004240050552  0.668
1996 Steele DS, McAinsh AM, Smith GL. Comparative effects of inorganic phosphate and oxalate on uptake and release of Ca2+ by the sarcoplasmic reticulum in saponin skinned rat cardiac trabeculae. The Journal of Physiology. 490: 565-76. PMID 8683457  0.559
1995 Steele DS, McAinsh AM, Smith GL. Effects of creatine phosphate and inorganic phosphate on the sarcoplasmic reticulum of saponin-treated rat heart. The Journal of Physiology. 483: 155-66. PMID 7776229 DOI: 10.1113/jphysiol.1995.sp020575  0.561
1994 MacFarlane NG, Miller DJ, Smith GL, Steele DS. Effects of oxidants on the sarcoplasmic reticulum of saponin treated rat ventricular trabeculae. Cardiovascular Research. 28: 1647-52. PMID 7842458 DOI: 10.1093/Cvr/28.11.1647  0.695
1993 Steele DS, Smith GL. Effects of 2,3-butanedione monoxime on sarcoplasmic reticulum of saponin-treated rat cardiac muscle. The American Journal of Physiology. 265: H1493-500. PMID 8238560 DOI: 10.1152/Ajpheart.1993.265.5.H1493  0.693
1993 Steele DS, Smith GL. Effects of muscle length on diastolic [Ca2+](i) in isolated guinea-pig ventricular trabeculae Journal of Physiology. 467: 328P.  0.465
1992 Smith GL, Steele DS, Crichton CA. Effects of inorganic phosphate on calcium and tension oscillations in saponin-treated rat cardiac muscle. Advances in Experimental Medicine and Biology. 311: 387-8. PMID 1529773  0.79
1992 Steele DS, Smith GL. The effects of caffeine and Ca2+ on rigor tension in triton-treated rat ventricular trabeculae. PflüGers Archiv : European Journal of Physiology. 421: 343-9. PMID 1408658 DOI: 10.1007/Bf00374222  0.639
1992 Steele DS, Miller DJ. Effects of cAMP and forskolin on caffeine-induced contractures and myofilament Ca-sensitivity in saponin-treated rat ventricular trabeculae. Journal of Muscle Research and Cell Motility. 13: 146-52. PMID 1317880 DOI: 10.1007/Bf01874151  0.654
1992 Smith GL, Steele DS. Inorganic phosphate decreases the Ca2+ content of the sarcoplasmic reticulum in saponin-treated rat cardiac trabeculae. The Journal of Physiology. 458: 457-73. PMID 1302274 DOI: 10.1113/jphysiol.1992.sp019427  0.558
1992 Smith GL, Crichton CA, Steele DS. The effect of EGTA on Ca2+-activated force in α-toxin permeabilized rat anococcygeus muscle Journal of Physiology. 446: 243P.  0.753
1992 Smith GL, Steele DS, Crichton CA. The effect of inorganic phosphate on the SR of isolated saponin-treated rat heart Journal of Physiology. 446: 147P.  0.695
1990 Steele DS, Smith GL, Miller DJ. The effects of taurine on Ca2+ uptake by the sarcoplasmic reticulum and Ca2+ sensitivity of chemically skinned rat heart. The Journal of Physiology. 422: 499-511. PMID 2352190 DOI: 10.1113/Jphysiol.1990.Sp017997  0.715
1990 Miller DJ, Steele DS. The 'calcium sensitising' effects of ORG30029 in saponin- or Triton-skinned rat cardiac muscle. British Journal of Pharmacology. 100: 843-9. PMID 2207503 DOI: 10.1111/J.1476-5381.1990.Tb14102.X  0.641
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