Delphine Boche - Publications

Affiliations: 
Academic Unit of Clinical and Experimental Sciences University of Southampton, Southampton, England, United Kingdom 

65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Amin J, Gee C, Stowell K, Coulthard D, Boche D. T Lymphocytes and Their Potential Role in Dementia with Lewy Bodies. Cells. 12. PMID 37759503 DOI: 10.3390/cells12182283  0.341
2023 Hartnell IJ, Woodhouse D, Jasper W, Mason L, Marwaha P, Graffeuil M, Lau LC, Norman JL, Chatelet DS, Buee L, Nicoll JAR, Blum D, Dorothee G, Boche D. Glial reactivity and T cell infiltration in frontotemporal lobar degeneration with tau pathology. Brain : a Journal of Neurology. PMID 37703311 DOI: 10.1093/brain/awad309  0.316
2023 Garland EF, Dennett O, Lau LC, Chatelet DS, Bottlaender M, Nicoll JAR, Boche D. The mitochondrial protein TSPO in Alzheimer's disease: relation to the severity of AD pathology and the neuroinflammatory environment. Journal of Neuroinflammation. 20: 186. PMID 37580767 DOI: 10.1186/s12974-023-02869-9  0.317
2022 Salehipour A, Bagheri M, Sabahi M, Dolatshahi M, Boche D. Combination Therapy in Alzheimer's Disease: Is It Time? Journal of Alzheimer's Disease : Jad. PMID 35491785 DOI: 10.3233/JAD-215680  0.326
2022 Amin J, Erskine D, Donaghy PC, Surendranathan A, Swann P, Kunicki AP, Boche D, Holmes C, McKeith IG, O'Brien JT, Teeling JL, Thomas AJ. Inflammation in dementia with Lewy bodies. Neurobiology of Disease. 168: 105698. PMID 35314318 DOI: 10.1016/j.nbd.2022.105698  0.418
2022 Scherlek AA, Kozberg MG, Nicoll JAR, Perosa V, Freeze WM, van der Weerd L, Bacskai BJ, Greenberg SM, Frosch MP, Boche D, van Veluw SJ. Histopathological correlates of haemorrhagic lesions on magnetic resonance imaging in immunized Alzheimer's disease cases. Brain Communications. 4: fcac021. PMID 35224489 DOI: 10.1093/braincomms/fcac021  0.358
2021 Franco-Bocanegra DK, Gourari Y, McAuley C, Chatelet DS, Johnston DA, Nicoll JAR, Boche D. Microglial morphology in Alzheimer's disease and after Aβ immunotherapy. Scientific Reports. 11: 15955. PMID 34354209 DOI: 10.1038/s41598-021-95535-0  0.693
2021 Boche D, Gordon MN. Diversity of transcriptomic microglial phenotypes in aging and Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 34223696 DOI: 10.1002/alz.12389  0.431
2021 Beardmore R, Hou R, Darekar A, Holmes C, Boche D. The Locus Coeruleus in Aging and Alzheimer's Disease: A Postmortem and Brain Imaging Review. Journal of Alzheimer's Disease : Jad. PMID 34219717 DOI: 10.3233/JAD-210191  0.384
2021 Lopez-Rodriguez AB, Hennessy E, Murray CL, Nazmi A, Delaney HJ, Healy D, Fagan SG, Rooney M, Stewart E, Lewis A, de Barra N, Scarry P, Riggs-Miller L, Boche D, Cunningham MO, et al. Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL-1β drives amplified responses in primed astrocytes and neuronal network dysfunction. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 34080771 DOI: 10.1002/alz.12341  0.304
2021 Hartnell IJ, Blum D, Nicoll JAR, Dorothee G, Boche D. Glial cells and adaptive immunity in frontotemporal dementia with tau pathology. Brain : a Journal of Neurology. PMID 33527991 DOI: 10.1093/brain/awaa457  0.404
2020 Amin J, Boche D, Clough Z, Teeling J, Williams A, Gao Y, Chudley L, Lau L, Smith F, Harris S, Holmes C. Peripheral immunophenotype in dementia with Lewy bodies and Alzheimer's disease: an observational clinical study. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 32968032 DOI: 10.1136/jnnp-2020-323603  0.395
2020 Carare RO, Aldea R, Agarwal N, Bacskai BJ, Bechman I, Boche D, Bu G, Bulters D, Clemens A, Counts SE, de Leon M, Eide PK, Fossati S, Greenberg SM, Hamel E, et al. Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12053. PMID 32775596 DOI: 10.1002/Dad2.12053  0.37
2020 Amin J, Holmes C, Dorey RB, Tommasino E, Casal YR, Williams DM, Dupuy C, Nicoll JAR, Boche D. Neuroinflammation in dementia with Lewy bodies: a human post-mortem study. Translational Psychiatry. 10: 267. PMID 32747635 DOI: 10.1038/s41398-020-00954-8  0.303
2020 Boche D, Nicoll JAR. Invited Review - Understanding cause and effect in Alzheimer's pathophysiology: Implications for clinical trials. Neuropathology and Applied Neurobiology. 46: 623-640. PMID 32643143 DOI: 10.1111/nan.12642  0.451
2020 Beardmore RC, Darekar A, Holmes C, Boche D, Nicoll JA, Durkin M, Hou R. Using the Locus Coeruleus as a biomarker in Alzheimer's disease Alzheimer's & Dementia. 16. DOI: 10.1002/alz.040229  0.325
2019 Franco-Bocanegra DK, George B, Lau LC, Holmes C, Nicoll JAR, Boche D. Microglial motility in Alzheimer's disease and after Aβ42 immunotherapy: a human post-mortem study. Acta Neuropathologica Communications. 7: 174. PMID 31703599 DOI: 10.1186/s40478-019-0828-x  0.698
2019 Jäkel L, Boche D, Nicoll JAR, Verbeek MM. Aβ43 in human Alzheimer's disease: effects of active Aβ42 immunization. Acta Neuropathologica Communications. 7: 141. PMID 31477180 DOI: 10.1186/s40478-019-0791-6  0.409
2019 Boche D, Gerhard A, Rodriguez-Vieitez E. Prospects and challenges of imaging neuroinflammation beyond TSPO in Alzheimer's disease. European Journal of Nuclear Medicine and Molecular Imaging. PMID 31396666 DOI: 10.1007/S00259-019-04462-W  0.327
2019 Franco-Bocanegra DK, McAuley C, Nicoll JAR, Boche D. Molecular Mechanisms of Microglial Motility: Changes in Ageing and Alzheimer's Disease. Cells. 8. PMID 31242692 DOI: 10.3390/cells8060639  0.682
2019 Nicoll JAR, Buckland GR, Harrison CH, Page A, Harris S, Love S, Neal JW, Holmes C, Boche D. Persistent neuropathological effects 14 years following amyloid-β immunization in Alzheimer's disease. Brain : a Journal of Neurology. PMID 31157360 DOI: 10.1093/Brain/Awz142  0.388
2018 Moro ML, Phillips AS, Gaimster K, Paul C, Mudher A, Nicoll JAR, Boche D. Pyroglutamate and Isoaspartate modified Amyloid-Beta in ageing and Alzheimer's disease. Acta Neuropathologica Communications. 6: 3. PMID 29298722 DOI: 10.1186/s40478-017-0505-x  0.439
2018 Fahrenhold M, Rakic S, Classey J, Brayne C, Ince PG, Nicoll JAR, Boche D. TREM2 expression in the human brain: a marker of monocyte recruitment? Brain Pathology (Zurich, Switzerland). 28: 595-602. PMID 28987033 DOI: 10.1111/bpa.12564  0.374
2018 Franco Bocanegra DK, Nicoll JAR, Boche D. Innate immunity in Alzheimer's disease: the relevance of animal models? Journal of Neural Transmission (Vienna, Austria : 1996). 125: 827-846. PMID 28516241 DOI: 10.1007/s00702-017-1729-4  0.374
2017 Paquet C, Nicoll JA, Love S, Mouton-Liger F, Holmes C, Hugon J, Boche D. DOWNREGULATED APOPTOSIS AND AUTOPHAGY AFTER ANTI-Aβ IMMUNOTHERAPY IN ALZHEIMER'S DISEASE. Brain Pathology (Zurich, Switzerland). PMID 29027727 DOI: 10.1111/Bpa.12567  0.419
2016 Minett T, Classey J, Matthews FE, Fahrenhold M, Taga M, Brayne C, Ince PG, Nicoll JA, Boche D. Microglial immunophenotype in dementia with Alzheimer's pathology. Journal of Neuroinflammation. 13: 135. PMID 27256292 DOI: 10.1186/s12974-016-0601-z  0.384
2016 Taga M, Minett T, Classey J, Matthews FE, Brayne C, Ince PG, Nicoll JA, Hugon J, Boche D. Metaflammasome components in the human brain: a role in dementia with alzheimer's pathology? Brain Pathology (Zurich, Switzerland). PMID 27106634 DOI: 10.1111/bpa.12388  0.375
2015 De Lucia C, Rinchon A, Olmos-Alonso A, Riecken K, Fehse B, Boche D, Perry VH, Gomez-Nicola D. Microglia regulate hippocampal neurogenesis during chronic neurodegeneration. Brain, Behavior, and Immunity. PMID 26541819 DOI: 10.1016/j.bbi.2015.11.001  0.517
2015 Gomez-Nicola D, Boche D. Post-mortem analysis of neuroinflammatory changes in human Alzheimer's disease. Alzheimer's Research & Therapy. 7: 42. PMID 25904988 DOI: 10.1186/s13195-015-0126-1  0.354
2015 Amin J, Paquet C, Baker A, Asuni AA, Love S, Holmes C, Hugon J, Nicoll JA, Boche D. Effect of amyloid-β (Aβ) immunization on hyperphosphorylated tau: a potential role for glycogen synthase kinase (GSK)-3β. Neuropathology and Applied Neurobiology. 41: 445-57. PMID 25486988 DOI: 10.1111/Nan.12205  0.625
2015 Paquet C, Amin J, Mouton-Liger F, Nasser M, Love S, Gray F, Pickering RM, Nicoll JA, Holmes C, Hugon J, Boche D. Effect of active Aβ immunotherapy on neurons in human Alzheimer's disease. The Journal of Pathology. 235: 721-30. PMID 25430817 DOI: 10.1002/Path.4491  0.382
2014 Sakai K, Boche D, Carare R, Johnston D, Holmes C, Love S, Nicoll JA. Aβ immunotherapy for Alzheimer's disease: effects on apoE and cerebral vasculopathy. Acta Neuropathologica. 128: 777-89. PMID 25195061 DOI: 10.1007/S00401-014-1340-9  0.394
2013 Proctor CJ, Boche D, Gray DA, Nicoll JA. Investigating interventions in Alzheimer's disease with computer simulation models. Plos One. 8: e73631. PMID 24098635 DOI: 10.1371/Journal.Pone.0073631  0.372
2013 Zotova E, Bharambe V, Cheaveau M, Morgan W, Holmes C, Harris S, Neal JW, Love S, Nicoll JA, Boche D. Inflammatory components in human Alzheimer's disease and after active amyloid-β42 immunization. Brain : a Journal of Neurology. 136: 2677-96. PMID 23943781 DOI: 10.1093/Brain/Awt210  0.397
2013 Boche D, Perry VH, Nicoll JA. Review: activation patterns of microglia and their identification in the human brain. Neuropathology and Applied Neurobiology. 39: 3-18. PMID 23252647 DOI: 10.1111/Nan.12011  0.499
2013 Boche D, Zotova E, Bharambe V, Cheaveau M, Morgan W, Holmes C, Harris S, Neal J, Love S, Nicoll J. Characterizing inflammatory components in human Alzheimer's disease and following active beta-amyloid 42 immunization Alzheimers & Dementia. 9. DOI: 10.1016/J.Jalz.2013.05.570  0.342
2013 Nicoll J, Sakai K, Love S, Boche D. Cerebral amyloid angiopathy-associated vasculopathy and apolipoprotein E accumulation after beta-amyloid immunotherapy for Alzheimer's disease Alzheimers & Dementia. 9: 529. DOI: 10.1016/J.Jalz.2013.04.268  0.325
2012 Galea J, Cruickshank G, Teeling JL, Boche D, Garland P, Perry VH, Galea I. The intrathecal CD163-haptoglobin-hemoglobin scavenging system in subarachnoid hemorrhage. Journal of Neurochemistry. 121: 785-92. PMID 22380637 DOI: 10.1111/j.1471-4159.2012.07716.x  0.38
2012 Boche D. S.13.01 Immunotherapy in Alzheimer's disease: is Aβ the right target? European Neuropsychopharmacology. 22: S130. DOI: 10.1016/S0924-977X(12)70158-X  0.315
2011 Zotova E, Holmes C, Johnston D, Neal JW, Nicoll JA, Boche D. Microglial alterations in human Alzheimer's disease following Aβ42 immunization. Neuropathology and Applied Neurobiology. 37: 513-24. PMID 21166690 DOI: 10.1111/j.1365-2990.2010.01156.x  0.45
2011 Zotova E, Holmes C, Neal J, Love S, Nicoll J, Boche D. Lower microglial Fcγ RI/II and macrophage scavenger receptor a in human Alzheimer's disease after Aβ42 immunisation. Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.1976  0.353
2010 Boche D, Denham N, Holmes C, Nicoll JA. Neuropathology after active Abeta42 immunotherapy: implications for Alzheimer's disease pathogenesis. Acta Neuropathologica. 120: 369-84. PMID 20632020 DOI: 10.1007/s00401-010-0719-5  0.368
2010 Boche D, Donald J, Love S, Harris S, Neal JW, Holmes C, Nicoll JA. Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Abeta42 immunisation in Alzheimer's disease. Acta Neuropathologica. 120: 13-20. PMID 20532897 DOI: 10.1007/S00401-010-0705-Y  0.44
2010 Boche D, Nicoll JA. Are we getting to grips with Alzheimer's disease at last? Brain : a Journal of Neurology. 133: 1297-9. PMID 20418529 DOI: 10.1093/brain/awq099  0.344
2010 Zotova E, Nicoll JA, Kalaria R, Holmes C, Boche D. Inflammation in Alzheimer's disease: relevance to pathogenesis and therapy. Alzheimer's Research & Therapy. 2: 1. PMID 20122289 DOI: 10.1186/alzrt24  0.43
2010 Nicoll JA, Hawkes C, Holmes C, Weller R, Perry H, Boche D, Teeling J, Carare R. O3-07-06: Processes underlying the vascular pathophysiology associated with Aβ immunization in Alzheimer's disease Alzheimer's & Dementia. 6: S143-S143. DOI: 10.1016/j.jalz.2010.05.440  0.319
2010 Boche D, Donald J, Love S, Neal JW, Holmes C, Nicoll J. Aβ42 immunization reduces both tau and Aβ deposits in Alzheimer's disease Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.2019  0.407
2009 Weller RO, Boche D, Nicoll JA. Microvasculature changes and cerebral amyloid angiopathy in Alzheimer's disease and their potential impact on therapy. Acta Neuropathologica. 118: 87-102. PMID 19234858 DOI: 10.1007/s00401-009-0498-z  0.376
2009 Paquet C, Boche D, Gray F, Hugon J, Nicoll J. P2-164: Aβ vaccination induces modifications of neuronal activated PKR staining in the brains of patients with Alzheimer's Disease (AD) Alzheimer's & Dementia. 5: P309-P309. DOI: 10.1016/j.jalz.2009.04.476  0.399
2008 Boche D, Zotova E, Weller RO, Love S, Neal JW, Pickering RM, Wilkinson D, Holmes C, Nicoll JA. Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain. Brain : a Journal of Neurology. 131: 3299-310. PMID 18953056 DOI: 10.1093/Brain/Awn261  0.322
2008 Holmes C, Boche D, Wilkinson D, Yadegarfar G, Hopkins V, Bayer A, Jones RW, Bullock R, Love S, Neal JW, Zotova E, Nicoll JA. Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet. 372: 216-23. PMID 18640458 DOI: 10.1016/S0140-6736(08)61075-2  0.364
2008 Boche D, Nicoll JA. The role of the immune system in clearance of Abeta from the brain. Brain Pathology (Zurich, Switzerland). 18: 267-78. PMID 18363937 DOI: 10.1111/j.1750-3639.2008.00134.x  0.456
2008 Boche D, Zotova E, Holmes C, Nicoll JA. O2-03-05: Microglia and Alzheimer's disease: Implications of Aβ immunotherapy Alzheimer's & Dementia. 4: T136-T137. DOI: 10.1016/j.jalz.2008.05.326  0.347
2006 Boche D, Nicoll JA, Weller RO. Immunotherapy for Alzheimer's disease and other dementias. Clinical Neuropharmacology. 29: 22-7. PMID 16518131 DOI: 10.1097/00002826-200601000-00008  0.376
2006 Boche D, Cunningham C, Docagne F, Scott H, Perry VH. TGFbeta1 regulates the inflammatory response during chronic neurodegeneration. Neurobiology of Disease. 22: 638-50. PMID 16510291 DOI: 10.1016/j.nbd.2006.01.004  0.533
2005 Boche D, Nicoll JA, Weller RO. Immunotherapy for Alzheimer's disease and other dementias. Current Opinion in Neurology. 18: 720-5. PMID 16280685  0.376
2005 Felton LM, Cunningham C, Rankine EL, Waters S, Boche D, Perry VH. MCP-1 and murine prion disease: separation of early behavioural dysfunction from overt clinical disease. Neurobiology of Disease. 20: 283-95. PMID 15886005 DOI: 10.1016/J.Nbd.2005.03.008  0.503
2005 Cunningham C, Wilcockson DC, Boche D, Perry VH. Comparison of inflammatory and acute-phase responses in the brain and peripheral organs of the ME7 model of prion disease. Journal of Virology. 79: 5174-84. PMID 15795301 DOI: 10.1128/JVI.79.8.5174-5184.2005  0.568
2005 Cunningham C, Deacon RM, Chan K, Boche D, Rawlins JN, Perry VH. Neuropathologically distinct prion strains give rise to similar temporal profiles of behavioral deficits. Neurobiology of Disease. 18: 258-69. PMID 15686954 DOI: 10.1016/J.Nbd.2004.08.015  0.391
2005 Galea I, Palin K, Newman TA, Van Rooijen N, Perry VH, Boche D. Mannose receptor expression specifically reveals perivascular macrophages in normal, injured, and diseased mouse brain. Glia. 49: 375-84. PMID 15538754 DOI: 10.1002/glia.20124  0.486
2004 Picanço-Diniz CW, Boche D, Gomes-Leal W, Perry VH, Cunningham C. Neuropil and neuronal changes in hippocampal NADPH-diaphorase histochemistry in the ME7 model of murine prion disease. Neuropathology and Applied Neurobiology. 30: 292-303. PMID 15175082 DOI: 10.1111/J.1365-2990.2004.00537.X  0.491
2003 Boche D, Cunningham C, Gauldie J, Perry VH. Transforming growth factor-beta 1-mediated neuroprotection against excitotoxic injury in vivo. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 23: 1174-82. PMID 14526228 DOI: 10.1097/01.Wcb.0000090080.64176.44  0.406
2003 Cunningham C, Deacon R, Wells H, Boche D, Waters S, Diniz CP, Scott H, Rawlins JN, Perry VH. Synaptic changes characterize early behavioural signs in the ME7 model of murine prion disease. The European Journal of Neuroscience. 17: 2147-55. PMID 12786981 DOI: 10.1046/J.1460-9568.2003.02662.X  0.507
2002 Perry VH, Cunningham C, Boche D. Atypical inflammation in the central nervous system in prion disease. Current Opinion in Neurology. 15: 349-54. PMID 12045736 DOI: 10.1097/00019052-200206000-00020  0.481
2002 Cunningham C, Boche D, Perry VH. Transforming growth factor beta1, the dominant cytokine in murine prion disease: influence on inflammatory cytokine synthesis and alteration of vascular extracellular matrix. Neuropathology and Applied Neurobiology. 28: 107-19. PMID 11972797 DOI: 10.1046/J.1365-2990.2002.00383.X  0.426
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