| Year |
Citation |
Score |
| 2024 |
Zhu Y, Fujimaki M, Snape L, Lopez A, Fleming A, Rubinsztein DC. Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis. Nature Cell Biology. PMID 38454050 DOI: 10.1038/s41556-024-01373-3 |
0.344 |
|
| 2024 |
Chen X, Tsvetkov AS, Shen HM, Isidoro C, Ktistakis NT, Linkermann A, Koopman WJH, Simon HU, Galluzzi L, Luo S, Xu D, Gu W, Peulen O, Cai Q, Rubinsztein DC, et al. International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis. Autophagy. PMID 38442890 DOI: 10.1080/15548627.2024.2319901 |
0.312 |
|
| 2024 |
Son SM, Park SJ, Breusegem SY, Larrieu D, Rubinsztein DC. p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson-Gilford progeria syndrome. Nature Cell Biology. PMID 38267537 DOI: 10.1038/s41556-023-01338-y |
0.326 |
|
| 2023 |
Ryan L, Rubinsztein DC. The autophagy of stress granules. Febs Letters. PMID 38101818 DOI: 10.1002/1873-3468.14787 |
0.338 |
|
| 2023 |
Festa BP, Siddiqi FH, Jimenez-Sanchez M, Won H, Rob M, Djajadikerta A, Stamatakou E, Rubinsztein DC. Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration. Neuron. PMID 37105172 DOI: 10.1016/j.neuron.2023.04.006 |
0.332 |
|
| 2022 |
Schlotawa L, Lopez A, Sanchez-Elexpuru G, Tyrkalska SD, Rubinsztein DC, Fleming A. An inducible expression system for the manipulation of autophagic flux . Autophagy. 1-14. PMID 36310368 DOI: 10.1080/15548627.2022.2135824 |
0.321 |
|
| 2022 |
Wrobel L, Hill SM, Rubinsztein DC. SMER28 binding to VCP/p97 enhances both autophagic and proteasomal neurotoxic protein clearance. Autophagy. 1-3. PMID 36036202 DOI: 10.1080/15548627.2022.2116832 |
0.354 |
|
| 2022 |
Wrobel L, Hill SM, Djajadikerta A, Fernandez-Estevez M, Karabiyik C, Ashkenazi A, Barratt VJ, Stamatakou E, Gunnarsson A, Rasmusson T, Miele EW, Beaton N, Bruderer R, Feng Y, Reiter L, ... ... Rubinsztein DC, et al. Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance. Nature Communications. 13: 4146. PMID 35842429 DOI: 10.1038/s41467-022-31905-0 |
0.774 |
|
| 2022 |
Fleming A, Bourdenx M, Fujimaki M, Karabiyik C, Krause GJ, Lopez A, Martín-Segura A, Puri C, Scrivo A, Skidmore J, Son SM, Stamatakou E, Wrobel L, Zhu Y, Cuervo AM, ... Rubinsztein DC, et al. The different autophagy degradation pathways and neurodegeneration. Neuron. PMID 35134347 DOI: 10.1016/j.neuron.2022.01.017 |
0.8 |
|
| 2021 |
Aman Y, Schmauck-Medina T, Hansen M, Morimoto RI, Simon AK, Bjedov I, Palikaras K, Simonsen A, Johansen T, Tavernarakis N, Rubinsztein DC, Partridge L, Kroemer G, Labbadia J, Fang EF. Autophagy in healthy aging and disease. Nature Aging. 1: 634-650. PMID 34901876 DOI: 10.1038/s43587-021-00098-4 |
0.308 |
|
| 2021 |
Park SJ, Frake RA, Karabiyik C, Son SM, Siddiqi FH, Bento CF, Sterk P, Vicinanza M, Pavel M, Rubinsztein DC. Vinexin contributes to autophagic decline in brain ageing across species. Cell Death and Differentiation. PMID 34848853 DOI: 10.1038/s41418-021-00903-y |
0.765 |
|
| 2021 |
Karabiyik C, Rubinsztein DC. Protocol for determining the regulation of lipid kinases and changes in phospholipids . Star Protocols. 2: 100926. PMID 34766030 DOI: 10.1016/j.xpro.2021.100926 |
0.743 |
|
| 2021 |
Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cadwell K, Cecconi F, Choi AMK, Choi ME, Chu CT, Codogno P, Colombo MI, Cuervo AM, ... ... Rubinsztein DC, et al. Autophagy in major human diseases. The Embo Journal. e108863. PMID 34459017 DOI: 10.15252/embj.2021108863 |
0.307 |
|
| 2021 |
Karabiyik C, Rubinsztein DC. AMPK-activated ULK1 phosphorylates PIKFYVE to drive formation of PtdIns5P-containing autophagosomes during glucose starvation. Autophagy. 1-2. PMID 34382905 DOI: 10.1080/15548627.2021.1961409 |
0.771 |
|
| 2021 |
Karabiyik C, Vicinanza M, Son SM, Rubinsztein DC. Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner. Developmental Cell. PMID 34107300 DOI: 10.1016/j.devcel.2021.05.010 |
0.783 |
|
| 2021 |
Karabiyik C, Son SM, Rubinsztein DC. Lysosome positioning and mTOR activity in Lowe syndrome. Embo Reports. e53232. PMID 34047002 DOI: 10.15252/embr.202153232 |
0.755 |
|
| 2021 |
Pavel M, Park SJ, Frake RA, Son SM, Manni MM, Bento CF, Renna M, Ricketts T, Menzies FM, Tanasa R, Rubinsztein DC. α-Catenin levels determine direction of YAP/TAZ response to autophagy perturbation. Nature Communications. 12: 1703. PMID 33731717 DOI: 10.1038/s41467-021-21882-1 |
0.306 |
|
| 2021 |
Wrobel L, Hill SM, Ashkenazi A, Rubinsztein DC. VCP/p97 modulates PtdIns3P production and autophagy initiation. Autophagy. 1-2. PMID 33719912 DOI: 10.1080/15548627.2021.1898742 |
0.339 |
|
| 2021 |
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, ... ... Rubinsztein DC, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 1-382. PMID 33634751 DOI: 10.1080/15548627.2020.1797280 |
0.649 |
|
| 2021 |
Hill SM, Wrobel L, Ashkenazi A, Fernandez-Estevez M, Tan K, Bürli RW, Rubinsztein DC. VCP/p97 regulates Beclin-1-dependent autophagy initiation. Nature Chemical Biology. PMID 33510452 DOI: 10.1038/s41589-020-00726-x |
0.392 |
|
| 2021 |
Son SM, Park SJ, Fernandez-Estevez M, Rubinsztein DC. Autophagy regulation by acetylation-implications for neurodegenerative diseases. Experimental & Molecular Medicine. PMID 33483607 DOI: 10.1038/s12276-021-00556-4 |
0.397 |
|
| 2020 |
Stamatakou E, Wróbel L, Hill SM, Puri C, Son SM, Fujimaki M, Zhu Y, Siddiqi F, Fernandez-Estevez M, Manni MM, Park SJ, Villeneuve J, Rubinsztein DC. Mendelian neurodegenerative disease genes involved in autophagy. Cell Discovery. 6: 24. PMID 33947844 DOI: 10.1038/s41421-020-0158-y |
0.367 |
|
| 2020 |
Wrobel L, Siddiqi FH, Hill SM, Son SM, Karabiyik C, Kim H, Rubinsztein DC. mTORC2 Assembly Is Regulated by USP9X-Mediated Deubiquitination of RICTOR. Cell Reports. 33: 108564. PMID 33378666 DOI: 10.1016/j.celrep.2020.108564 |
0.773 |
|
| 2020 |
Son SM, Park SJ, Stamatakou E, Vicinanza M, Menzies FM, Rubinsztein DC. Leucine regulates autophagy via acetylation of the mTORC1 component raptor. Nature Communications. 11: 3148. PMID 32561715 DOI: 10.1038/s41467-020-16886-2 |
0.364 |
|
| 2020 |
VerPlank JJS, Tyrkalska SD, Fleming A, Rubinsztein DC, Goldberg AL. cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases. Proceedings of the National Academy of Sciences of the United States of America. 117: 14220-14230. PMID 32513741 DOI: 10.1073/pnas.2003277117 |
0.3 |
|
| 2020 |
Stamatakou E, Wróbel L, Hill SM, Puri C, Son SM, Fujimaki M, Zhu Y, Siddiqi F, Fernandez-Estevez M, Manni MM, Park SJ, Villeneuve J, Rubinsztein DC. Mendelian neurodegenerative disease genes involved in autophagy. Cell Discovery. 6: 24. PMID 32377374 DOI: 10.1038/s41421-020-0158-y |
0.367 |
|
| 2020 |
Ejlerskov P, Rubinsztein DC, Pocock R. IFNB/interferon-β regulates autophagy via a -TBC1D15-RAB7 pathway. Autophagy. 1-3. PMID 31958036 DOI: 10.1080/15548627.2020.1718384 |
0.342 |
|
| 2019 |
Djajadikerta A, Keshri S, Pavel M, Prestil R, Ryan L, Rubinsztein DC. Autophagy induction as a therapeutic strategy for neurodegenerative diseases. Journal of Molecular Biology. PMID 31887286 DOI: 10.1016/j.jmb.2019.12.035 |
0.352 |
|
| 2019 |
Runwal G, Stamatakou E, Siddiqi FH, Puri C, Zhu Y, Rubinsztein DC. LC3-positive structures are prominent in autophagy-deficient cells. Scientific Reports. 9: 10147. PMID 31300716 DOI: 10.1038/s41598-019-46657-z |
0.316 |
|
| 2019 |
Siddiqi FH, Menzies FM, Lopez A, Stamatakou E, Karabiyik C, Ureshino R, Ricketts T, Jimenez-Sanchez M, Esteban MA, Lai L, Tortorella MD, Luo Z, Liu H, Metzakopian E, Fernandes HJR, ... ... Rubinsztein DC, et al. Author Correction: Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing. Nature Communications. 10: 2530. PMID 31164655 DOI: 10.1038/S41467-019-10536-Y |
0.744 |
|
| 2019 |
Siddiqi FH, Menzies FM, Lopez A, Stamatakou E, Karabiyik C, Ureshino R, Ricketts T, Jimenez-Sanchez M, Esteban MA, Lai L, Tortorella MD, Luo Z, Liu H, Metzakopian E, Fernandes HJR, ... ... Rubinsztein DC, et al. Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing. Nature Communications. 10: 1817. PMID 31000720 DOI: 10.1038/S41467-019-09494-2 |
0.775 |
|
| 2019 |
Hill SM, Wrobel L, Rubinsztein DC. Post-translational modifications of Beclin 1 provide multiple strategies for autophagy regulation. Cell Death and Differentiation. 26: 617-629. PMID 30546075 DOI: 10.1038/s41418-018-0254-9 |
0.378 |
|
| 2019 |
Ejlerskov P, Ashkenazi A, Rubinsztein DC. Genetic enhancement of macroautophagy in vertebrate models of neurodegenerative diseases. Neurobiology of Disease. 122: 3-8. PMID 29625255 DOI: 10.1016/j.nbd.2018.04.001 |
0.332 |
|
| 2018 |
Zhu Y, Runwal G, Obrocki P, Rubinsztein DC. Autophagy in childhood neurological disorders. Developmental Medicine and Child Neurology. PMID 30417343 DOI: 10.1111/dmcn.14092 |
0.322 |
|
| 2018 |
Lopez A, Fleming A, Rubinsztein DC. Seeing is believing: methods to monitor vertebrate autophagy . Open Biology. 8. PMID 30355753 DOI: 10.1098/rsob.180106 |
0.384 |
|
| 2018 |
Son SM, Park SJ, Lee H, Siddiqi F, Lee JE, Menzies FM, Rubinsztein DC. Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A. Cell Metabolism. PMID 30197302 DOI: 10.1016/j.cmet.2018.08.013 |
0.301 |
|
| 2018 |
Boland B, Yu WH, Corti O, Mollereau B, Henriques A, Bezard E, Pastores GM, Rubinsztein DC, Nixon RA, Duchen MR, Mallucci GR, Kroemer G, Levine B, Eskelinen EL, Mochel F, et al. Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing. Nature Reviews. Drug Discovery. PMID 30116051 DOI: 10.1038/Nrd.2018.109 |
0.312 |
|
| 2018 |
Hansen M, Rubinsztein DC, Walker DW. Autophagy as a promoter of longevity: insights from model organisms. Nature Reviews. Molecular Cell Biology. PMID 30006559 DOI: 10.1038/s41580-018-0033-y |
0.344 |
|
| 2018 |
Stamatakou E, Zhu Y, Rubinsztein DC. Assessing Autophagic Activity and Aggregate Formation of Mutant Huntingtin in Mammalian Cells. Methods in Molecular Biology (Clifton, N.J.). 1780: 17-29. PMID 29856012 DOI: 10.1007/978-1-4939-7825-0_2 |
0.324 |
|
| 2018 |
Carroll B, Otten EG, Manni D, Stefanatos R, Menzies FM, Smith GR, Jurk D, Kenneth N, Wilkinson S, Passos JF, Attems J, Veal EA, Teyssou E, Seilhean D, Millecamps S, ... ... Rubinsztein DC, et al. Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis. Nature Communications. 9: 256. PMID 29343728 DOI: 10.1038/S41467-017-02746-Z |
0.759 |
|
| 2018 |
Rubinsztein DC, Frake RA. Yoshinori Ohsumi's Nobel Prize for mechanisms of autophagy: from basic yeast biology to therapeutic potential. The Journal of the Royal College of Physicians of Edinburgh. 46: 228-233. PMID 28504774 DOI: 10.4997/JRCPE.2016.403 |
0.327 |
|
| 2017 |
Karabiyik C, Lee MJ, Rubinsztein DC. Autophagy impairment in Parkinson's disease. Essays in Biochemistry. 61: 711-720. PMID 29233880 DOI: 10.1042/EBC20170023 |
0.778 |
|
| 2017 |
Ashkenazi A, Bento CF, Ricketts T, Vicinanza M, Siddiqi F, Pavel M, Squitieri F, Hardenberg MC, Imarisio S, Menzies FM, Rubinsztein DC. Polyglutamine tracts regulate autophagy. Autophagy. 0. PMID 28722507 DOI: 10.1080/15548627.2017.1336278 |
0.381 |
|
| 2017 |
Ashkenazi A, Bento CF, Ricketts T, Vicinanza M, Siddiqi F, Pavel M, Squitieri F, Hardenberg MC, Imarisio S, Menzies FM, Rubinsztein DC. Polyglutamine tracts regulate beclin 1-dependent autophagy. Nature. PMID 28445460 DOI: 10.1038/nature22078 |
0.373 |
|
| 2017 |
Menzies FM, Fleming A, Caricasole A, Bento CF, Andrews SP, Ashkenazi A, Füllgrabe J, Jackson A, Jimenez Sanchez M, Karabiyik C, Licitra F, Lopez Ramirez A, Pavel M, Puri C, Renna M, ... ... Rubinsztein DC, et al. Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities. Neuron. 93: 1015-1034. PMID 28279350 DOI: 10.1016/j.neuron.2017.01.022 |
0.792 |
|
| 2016 |
Pavel M, Imarisio S, Menzies FM, Jimenez-Sanchez M, Siddiqi FH, Wu X, Renna M, O'Kane CJ, Crowther DC, Rubinsztein DC. CCT complex restricts neuropathogenic protein aggregation via autophagy. Nature Communications. 7: 13821. PMID 27929117 DOI: 10.1038/ncomms13821 |
0.369 |
|
| 2016 |
Füllgrabe J, Ghislat G, Cho DH, Rubinsztein DC. Transcriptional regulation of mammalian autophagy at a glance. Journal of Cell Science. 129: 3059-66. PMID 27528206 DOI: 10.1242/jcs.188920 |
0.341 |
|
| 2016 |
Vicinanza M, Rubinsztein DC. Mirror image phosphoinositides regulate autophagy. Molecular & Cellular Oncology. 3: e1019974. PMID 27308581 DOI: 10.1080/23723556.2015.1019974 |
0.342 |
|
| 2016 |
Bento CF, Ashkenazi A, Jimenez-Sanchez M, Rubinsztein DC. The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway. Nature Communications. 7: 11803. PMID 27278822 DOI: 10.1038/ncomms11803 |
0.327 |
|
| 2016 |
Klionsky DJ, Abdelmohsen K, Abe A, Abedin J, Abeliovich H, Arozena AA, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Rubinsztein DC, et al. Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 Autophagy. 12: 443-443. PMID 26902590 DOI: 10.1080/15548627.2016.1147886 |
0.525 |
|
| 2016 |
Bento CF, Renna M, Ghislat G, Puri C, Ashkenazi A, Vicinanza M, Menzies FM, Rubinsztein DC. Mammalian Autophagy: How Does It Work? Annual Review of Biochemistry. PMID 26865532 DOI: 10.1146/annurev-biochem-060815-014556 |
0.347 |
|
| 2016 |
Wu X, Fleming A, Ricketts T, Pavel M, Virgin H, Menzies FM, Rubinsztein DC. Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis. Nature Communications. 7: 10533. PMID 26837467 DOI: 10.1038/ncomms10533 |
0.329 |
|
| 2016 |
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Rubinsztein DC, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356 |
0.657 |
|
| 2015 |
Rubinsztein DC, Bento CF, Deretic V. Therapeutic targeting of autophagy in neurodegenerative and infectious diseases. The Journal of Experimental Medicine. 212: 979-90. PMID 26101267 DOI: 10.1084/Jem.20150956 |
0.362 |
|
| 2015 |
Menzies FM, Fleming A, Rubinsztein DC. Compromised autophagy and neurodegenerative diseases. Nature Reviews. Neuroscience. 16: 345-57. PMID 25991442 DOI: 10.1038/nrn3961 |
0.335 |
|
| 2015 |
Galluzzi L, Pietrocola F, Bravo-San Pedro JM, Amaravadi RK, Baehrecke EH, Cecconi F, Codogno P, Debnath J, Gewirtz DA, Karantza V, Kimmelman A, Kumar S, Levine B, Maiuri MC, Martin SJ, ... ... Rubinsztein DC, et al. Autophagy in malignant transformation and cancer progression. The Embo Journal. 34: 856-80. PMID 25712477 DOI: 10.15252/Embj.201490784 |
0.302 |
|
| 2015 |
Lin F, Ghislat G, Luo S, Renna M, Siddiqi F, Rubinsztein DC. XIAP and cIAP1 amplifications induce Beclin 1-dependent autophagy through NFκB activation. Human Molecular Genetics. 24: 2899-913. PMID 25669656 DOI: 10.1093/hmg/ddv052 |
0.32 |
|
| 2015 |
Frake RA, Ricketts T, Menzies FM, Rubinsztein DC. Autophagy and neurodegeneration. The Journal of Clinical Investigation. 125: 65-74. PMID 25654552 DOI: 10.1172/JCI73944 |
0.358 |
|
| 2015 |
Vicinanza M, Korolchuk VI, Ashkenazi A, Puri C, Menzies FM, Clarke JH, Rubinsztein DC. PI(5)P regulates autophagosome biogenesis. Molecular Cell. 57: 219-34. PMID 25578879 DOI: 10.1016/j.molcel.2014.12.007 |
0.642 |
|
| 2015 |
Menzies FM, Garcia-Arencibia M, Imarisio S, O'Sullivan NC, Ricketts T, Kent BA, Rao MV, Lam W, Green-Thompson ZW, Nixon RA, Saksida LM, Bussey TJ, O'Kane CJ, Rubinsztein DC. Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity. Cell Death and Differentiation. 22: 433-44. PMID 25257175 DOI: 10.1038/Cdd.2014.151 |
0.379 |
|
| 2014 |
Seguin SJ, Morelli FF, Vinet J, Amore D, De Biasi S, Poletti A, Rubinsztein DC, Carra S. Inhibition of autophagy, lysosome and VCP function impairs stress granule assembly Cell Death and Differentiation. 21: 1838-1851. PMID 25034784 DOI: 10.1038/cdd.2014.103 |
0.361 |
|
| 2014 |
Scotter EL, Vance C, Nishimura AL, Lee YB, Chen HJ, Urwin H, Sardone V, Mitchell JC, Rogelj B, Rubinsztein DC, Shaw CE. Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species. Journal of Cell Science. 127: 1263-78. PMID 24424030 DOI: 10.1242/jcs.140087 |
0.357 |
|
| 2013 |
Wu X, Won H, Rubinsztein DC. Autophagy and mammalian development. Biochemical Society Transactions. 41: 1489-94. PMID 24256242 DOI: 10.1042/BST20130185 |
0.307 |
|
| 2012 |
Jimenez-Sanchez M, Menzies FM, Chang YY, Simecek N, Neufeld TP, Rubinsztein DC. The Hedgehog signalling pathway regulates autophagy. Nature Communications. 3: 1200. PMID 23149744 DOI: 10.1038/Ncomms2212 |
0.362 |
|
| 2012 |
Luo S, Rubinsztein DC. BCL2L11/BIM: a novel molecular link between autophagy and apoptosis. Autophagy. 9: 104-5. PMID 23064249 DOI: 10.4161/auto.22399 |
0.327 |
|
| 2012 |
Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Rubinsztein DC, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496 |
0.63 |
|
| 2012 |
Rubinsztein DC, Codogno P, Levine B. Autophagy modulation as a potential therapeutic target for diverse diseases. Nature Reviews. Drug Discovery. 11: 709-30. PMID 22935804 DOI: 10.1038/nrd3802 |
0.372 |
|
| 2012 |
Menzies FM, Moreau K, Puri C, Renna M, Rubinsztein DC. Measurement of autophagic activity in mammalian cells. Current Protocols in Cell Biology. Unit 15.16. PMID 22422474 DOI: 10.1002/0471143030.cb1516s54 |
0.305 |
|
| 2012 |
Korolchuk VI, Rubinsztein DC. It's time to eat yourself healthy: On signals controlling autophagy The Biochemist. 34: 8-13. DOI: 10.1042/bio03402008 |
0.68 |
|
| 2011 |
Harris H, Rubinsztein DC. Control of autophagy as a therapy for neurodegenerative disease. Nature Reviews. Neurology. 8: 108-17. PMID 22187000 DOI: 10.1038/nrneurol.2011.200 |
0.384 |
|
| 2011 |
Klionsky DJ, Baehrecke EH, Brumell JH, Chu CT, Codogno P, Cuervo AM, Debnath J, Deretic V, Elazar Z, Eskelinen EL, Finkbeiner S, Fueyo-Margareto J, Gewirtz D, Jäättelä M, Kroemer G, ... ... Rubinsztein DC, et al. A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy. 7: 1273-94. PMID 21997368 DOI: 10.4161/Auto.7.11.17661 |
0.306 |
|
| 2011 |
Jimenez-Sanchez M, Thomson F, Zavodszky E, Rubinsztein DC. Autophagy and polyglutamine diseases. Progress in Neurobiology. 97: 67-82. PMID 21930185 DOI: 10.1016/j.pneurobio.2011.08.013 |
0.349 |
|
| 2011 |
Sarkar S, Korolchuk VI, Renna M, Imarisio S, Fleming A, Williams A, Garcia-Arencibia M, Rose C, Luo S, Underwood BR, Kroemer G, O'Kane CJ, Rubinsztein DC. Complex inhibitory effects of nitric oxide on autophagy. Molecular Cell. 43: 19-32. PMID 21726807 DOI: 10.1016/J.Molcel.2011.04.029 |
0.672 |
|
| 2011 |
Settembre C, Di Malta C, Polito VA, Garcia Arencibia M, Vetrini F, Erdin S, Erdin SU, Huynh T, Medina D, Colella P, Sardiello M, Rubinsztein DC, Ballabio A. TFEB links autophagy to lysosomal biogenesis. Science (New York, N.Y.). 332: 1429-33. PMID 21617040 DOI: 10.1126/Science.1204592 |
0.341 |
|
| 2011 |
Korolchuk VI, Rubinsztein DC. Regulation of autophagy by lysosomal positioning. Autophagy. 7: 927-8. PMID 21521941 DOI: 10.4161/auto.7.8.15862 |
0.638 |
|
| 2011 |
Korolchuk VI, Saiki S, Lichtenberg M, Siddiqi FH, Roberts EA, Imarisio S, Jahreiss L, Sarkar S, Futter M, Menzies FM, O'Kane CJ, Deretic V, Rubinsztein DC. Lysosomal positioning coordinates cellular nutrient responses. Nature Cell Biology. 13: 453-60. PMID 21394080 DOI: 10.1038/Ncb2204 |
0.625 |
|
| 2011 |
Fleming A, Rubinsztein DC. Zebrafish as a model to understand autophagy and its role in neurological disease. Biochimica Et Biophysica Acta. 1812: 520-6. PMID 21256213 DOI: 10.1016/j.bbadis.2011.01.004 |
0.309 |
|
| 2011 |
Renna M, Schaffner C, Winslow AR, Menzies FM, Peden AA, Floto RA, Rubinsztein DC. Autophagic substrate clearance requires activity of the syntaxin-5 SNARE complex. Journal of Cell Science. 124: 469-82. PMID 21242315 DOI: 10.1242/jcs.076489 |
0.371 |
|
| 2011 |
Fleming A, Noda T, Yoshimori T, Rubinsztein DC. Chemical modulators of autophagy as biological probes and potential therapeutics. Nature Chemical Biology. 7: 9-17. PMID 21164513 DOI: 10.1038/nchembio.500 |
0.358 |
|
| 2010 |
Rubinsztein DC, Nixon RA. Rapamycin induces autophagic flux in neurons. Proceedings of the National Academy of Sciences of the United States of America. 107: E181; author reply E. PMID 21115811 DOI: 10.1073/Pnas.1014633107 |
0.374 |
|
| 2010 |
Metcalf DJ, García-Arencibia M, Hochfeld WE, Rubinsztein DC. Autophagy and misfolded proteins in neurodegeneration. Experimental Neurology. 238: 22-8. PMID 21095248 DOI: 10.1016/j.expneurol.2010.11.003 |
0.371 |
|
| 2010 |
Ravikumar B, Sarkar S, Davies JE, Futter M, Garcia-Arencibia M, Green-Thompson ZW, Jimenez-Sanchez M, Korolchuk VI, Lichtenberg M, Luo S, Massey DC, Menzies FM, Moreau K, Narayanan U, Renna M, ... ... Rubinsztein DC, et al. Regulation of mammalian autophagy in physiology and pathophysiology. Physiological Reviews. 90: 1383-435. PMID 20959619 DOI: 10.1152/physrev.00030.2009 |
0.685 |
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| 2010 |
Knecht E, Aguado C, Sarkar S, Korolchuk VI, Criado-García O, Vernia S, Boya P, Sanz P, Rodríguez de Córdoba S, Rubinsztein DC. Impaired autophagy in Lafora disease. Autophagy. 6: 991-3. PMID 20818165 DOI: 10.4161/auto6.7.13308 |
0.635 |
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| 2010 |
Underwood BR, Imarisio S, Fleming A, Rose C, Krishna G, Heard P, Quick M, Korolchuk VI, Renna M, Sarkar S, GarcÃa-Arencibia M, O'Kane CJ, Murphy MP, Rubinsztein DC. Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease. Human Molecular Genetics. 19: 3413-29. PMID 20566712 DOI: 10.1093/Hmg/Ddq253 |
0.66 |
|
| 2010 |
Aguado C, Sarkar S, Korolchuk VI, Criado O, Vernia S, Boya P, Sanz P, de Córdoba SR, Knecht E, Rubinsztein DC. Laforin, the most common protein mutated in Lafora disease, regulates autophagy. Human Molecular Genetics. 19: 2867-76. PMID 20453062 DOI: 10.1093/hmg/ddq190 |
0.674 |
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| 2010 |
Rose C, Menzies FM, Renna M, Acevedo-Arozena A, Corrochano S, Sadiq O, Brown SD, Rubinsztein DC. Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease. Human Molecular Genetics. 19: 2144-53. PMID 20190273 DOI: 10.1093/hmg/ddq093 |
0.31 |
|
| 2010 |
García-Arencibia M, Hochfeld WE, Toh PP, Rubinsztein DC. Autophagy, a guardian against neurodegeneration. Seminars in Cell & Developmental Biology. 21: 691-8. PMID 20188203 DOI: 10.1016/j.semcdb.2010.02.008 |
0.418 |
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| 2010 |
Renna M, Jimenez-Sanchez M, Sarkar S, Rubinsztein DC. Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases. The Journal of Biological Chemistry. 285: 11061-7. PMID 20147746 DOI: 10.1074/jbc.R109.072181 |
0.357 |
|
| 2010 |
Menzies FM, Rubinsztein DC. Broadening the therapeutic scope for rapamycin treatment. Autophagy. 6: 286-7. PMID 20081360 DOI: 10.4161/auto.6.2.11078 |
0.319 |
|
| 2010 |
Moreau K, Luo S, Rubinsztein DC. Cytoprotective roles for autophagy. Current Opinion in Cell Biology. 22: 206-11. PMID 20045304 DOI: 10.1016/j.ceb.2009.12.002 |
0.384 |
|
| 2010 |
Korolchuk VI, Menzies FM, Rubinsztein DC. Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems. Febs Letters. 584: 1393-8. PMID 20040365 DOI: 10.1016/j.febslet.2009.12.047 |
0.659 |
|
| 2010 |
Rubinsztein DC. Autophagy: where next? Embo Reports. 11: 3. PMID 20033083 DOI: 10.1038/embor.2009.253 |
0.306 |
|
| 2009 |
Luo S, Rubinsztein DC. Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL. Cell Death and Differentiation. 17: 268-77. PMID 19713971 DOI: 10.1038/cdd.2009.121 |
0.321 |
|
| 2009 |
Ravikumar B, Futter M, Jahreiss L, Korolchuk VI, Lichtenberg M, Luo S, Massey DC, Menzies FM, Narayanan U, Renna M, Jimenez-Sanchez M, Sarkar S, Underwood B, Winslow A, Rubinsztein DC. Mammalian macroautophagy at a glance. Journal of Cell Science. 122: 1707-11. PMID 19461070 DOI: 10.1242/Jcs.031773 |
0.652 |
|
| 2009 |
Korolchuk VI, Menzies FM, Rubinsztein DC. A novel link between autophagy and the ubiquitin-proteasome system. Autophagy. 5: 862-3. PMID 19458478 DOI: 10.4161/auto.8840 |
0.673 |
|
| 2009 |
Rubinsztein DC, Cuervo AM, Ravikumar B, Sarkar S, Korolchuk V, Kaushik S, Klionsky DJ. In search of an "autophagomometer". Autophagy. 5: 585-9. PMID 19411822 DOI: 10.4161/Auto.5.5.8823 |
0.626 |
|
| 2009 |
Korolchuk VI, Mansilla A, Menzies FM, Rubinsztein DC. Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates. Molecular Cell. 33: 517-27. PMID 19250912 DOI: 10.1016/j.molcel.2009.01.021 |
0.662 |
|
| 2009 |
Sarkar S, Ravikumar B, Rubinsztein DC. Autophagic clearance of aggregate-prone proteins associated with neurodegeneration. Methods in Enzymology. 453: 83-110. PMID 19216903 DOI: 10.1016/S0076-6879(08)04005-6 |
0.385 |
|
| 2009 |
Sarkar S, Korolchuk V, Renna M, Winslow A, Rubinsztein DC. Methodological considerations for assessing autophagy modulators: A study with calcium phosphate precipitates Autophagy. 5: 307-313. PMID 19182529 DOI: 10.4161/auto.5.3.7664 |
0.646 |
|
| 2009 |
Sarkar S, Ravikumar B, Floto RA, Rubinsztein DC. Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies. Cell Death and Differentiation. 16: 46-56. PMID 18636076 DOI: 10.1038/cdd.2008.110 |
0.424 |
|
| 2008 |
Sarkar S, Rubinsztein DC. Small molecule enhancers of autophagy for neurodegenerative diseases. Molecular Biosystems. 4: 895-901. PMID 18704227 DOI: 10.1039/b804606a |
0.346 |
|
| 2008 |
Winslow AR, Rubinsztein DC. Autophagy in neurodegeneration and development Biochimica Et Biophysica Acta - Molecular Basis of Disease. 1782: 723-729. PMID 18644437 DOI: 10.1016/j.bbadis.2008.06.010 |
0.338 |
|
| 2008 |
Sarkar S, Rubinsztein DC. Huntington's disease: degradation of mutant huntingtin by autophagy. The Febs Journal. 275: 4263-70. PMID 18637946 DOI: 10.1111/j.1742-4658.2008.06562.x |
0.387 |
|
| 2008 |
Imarisio S, Carmichael J, Korolchuk V, Chen CW, Saiki S, Rose C, Krishna G, Davies JE, Ttofi E, Underwood BR, Rubinsztein DC. Huntington's disease: from pathology and genetics to potential therapies. The Biochemical Journal. 412: 191-209. PMID 18466116 DOI: 10.1042/BJ20071619 |
0.644 |
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| 2008 |
Ravikumar B, Imarisio S, Sarkar S, O'Kane CJ, Rubinsztein DC. Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease. Journal of Cell Science. 121: 1649-60. PMID 18430781 DOI: 10.1242/jcs.025726 |
0.345 |
|
| 2008 |
Ravikumar B, Sarkar S, Rubinsztein DC. Clearance of mutant aggregate-prone proteins by autophagy. Methods in Molecular Biology (Clifton, N.J.). 445: 195-211. PMID 18425452 DOI: 10.1007/978-1-59745-157-4_13 |
0.305 |
|
| 2008 |
Williams A, Sarkar S, Cuddon P, Ttofi EK, Saiki S, Siddiqi FH, Jahreiss L, Fleming A, Pask D, Goldsmith P, O'Kane CJ, Floto RA, Rubinsztein DC. Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nature Chemical Biology. 4: 295-305. PMID 18391949 DOI: 10.1038/nchembio.79 |
0.381 |
|
| 2008 |
Settembre C, Fraldi A, Rubinsztein DC, Ballabio A. Lysosomal storage diseases as disorders of autophagy. Autophagy. 4: 113-4. PMID 18000397 DOI: 10.4161/Auto.5227 |
0.308 |
|
| 2008 |
Settembre C, Fraldi A, Jahreiss L, Spampanato C, Venturi C, Medina D, de Pablo R, Tacchetti C, Rubinsztein DC, Ballabio A. A block of autophagy in lysosomal storage disorders. Human Molecular Genetics. 17: 119-29. PMID 17913701 DOI: 10.1093/Hmg/Ddm289 |
0.336 |
|
| 2007 |
Sarkar S, Krishna G, Imarisio S, Saiki S, O'Kane CJ, Rubinsztein DC. A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin. Human Molecular Genetics. 17: 170-8. PMID 17921520 DOI: 10.1093/HMG/DDM294 |
0.321 |
|
| 2007 |
Floto RA, Sarkar S, Perlstein EO, Kampmann B, Schreiber SL, Rubinsztein DC. Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages. Autophagy. 3: 620-2. PMID 17786022 DOI: 10.4161/Auto.4898 |
0.337 |
|
| 2007 |
Rubinsztein DC. Autophagy induction rescues toxicity mediated by proteasome inhibition. Neuron. 54: 854-6. PMID 17582326 DOI: 10.1016/j.neuron.2007.06.005 |
0.317 |
|
| 2007 |
Sarkar S, Perlstein EO, Imarisio S, Pineau S, Cordenier A, Maglathlin RL, Webster JA, Lewis TA, O'Kane CJ, Schreiber SL, Rubinsztein DC. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nature Chemical Biology. 3: 331-8. PMID 17486044 DOI: 10.1038/Nchembio883 |
0.32 |
|
| 2006 |
Sarkar S, Davies JE, Huang Z, Tunnacliffe A, Rubinsztein DC. Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. The Journal of Biological Chemistry. 282: 5641-52. PMID 17182613 DOI: 10.1074/jbc.M609532200 |
0.383 |
|
| 2006 |
Williams A, Jahreiss L, Sarkar S, Saiki S, Menzies FM, Ravikumar B, Rubinsztein DC. Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications. Current Topics in Developmental Biology. 76: 89-101. PMID 17118264 DOI: 10.1016/S0070-2153(06)76003-3 |
0.36 |
|
| 2006 |
Rubinsztein DC. The roles of intracellular protein-degradation pathways in neurodegeneration. Nature. 443: 780-6. PMID 17051204 DOI: 10.1038/nature05291 |
0.348 |
|
| 2006 |
Ravikumar B, Rubinsztein DC. Role of autophagy in the clearance of mutant huntingtin: a step towards therapy? Molecular Aspects of Medicine. 27: 520-7. PMID 16973207 DOI: 10.1016/j.mam.2006.08.008 |
0.394 |
|
| 2006 |
Sarkar S, Rubinsztein DC. Inositol and IP3 levels regulate autophagy: biology and therapeutic speculations. Autophagy. 2: 132-4. PMID 16874097 DOI: 10.4161/auto.2387 |
0.384 |
|
| 2006 |
Menzies FM, Ravikumar B, Rubinsztein DC. Protective roles for induction of autophagy in multiple proteinopathies. Autophagy. 2: 224-5. PMID 16874096 DOI: 10.4161/auto.2696 |
0.362 |
|
| 2006 |
Berger Z, Ravikumar B, Menzies FM, Oroz LG, Underwood BR, Pangalos MN, Schmitt I, Wullner U, Evert BO, O'Kane CJ, Rubinsztein DC. Rapamycin alleviates toxicity of different aggregate-prone proteins. Human Molecular Genetics. 15: 433-42. PMID 16368705 DOI: 10.1093/Hmg/Ddi458 |
0.301 |
|
| 2005 |
Rubinsztein DC, Ravikumar B, Acevedo-Arozena A, Imarisio S, O'Kane CJ, Brown SD. Dyneins, autophagy, aggregation and neurodegeneration. Autophagy. 1: 177-8. PMID 16874055 DOI: 10.4161/auto.1.3.2050 |
0.334 |
|
| 2005 |
Rubinsztein DC, DiFiglia M, Heintz N, Nixon RA, Qin ZH, Ravikumar B, Stefanis L, Tolkovsky A. Autophagy and its possible roles in nervous system diseases, damage and repair. Autophagy. 1: 11-22. PMID 16874045 DOI: 10.4161/Auto.1.1.1513 |
0.309 |
|
| 2005 |
Sarkar S, Floto RA, Berger Z, Imarisio S, Cordenier A, Pasco M, Cook LJ, Rubinsztein DC. Lithium induces autophagy by inhibiting inositol monophosphatase Journal of Cell Biology. 170: 1101-1111. PMID 16186256 DOI: 10.1083/Jcb.200504035 |
0.412 |
|
| 2005 |
Berger Z, Ttofi EK, Michel CH, Pasco MY, Tenant S, Rubinsztein DC, O'Kane CJ. Lithium rescues toxicity of aggregate-prone proteins in Drosophila by perturbing Wnt pathway Human Molecular Genetics. 14: 3003-3011. PMID 16141285 DOI: 10.1093/Hmg/Ddi331 |
0.305 |
|
| 2004 |
Ravikumar B, Rubinsztein DC. Can autophagy protect against neurodegeneration caused by aggregate-prone proteins? Neuroreport. 15: 2443-5. PMID 15538170 DOI: 10.1097/00001756-200411150-00001 |
0.325 |
|
| 2004 |
Webb JL, Ravikumar B, Rubinsztein DC. Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases. The International Journal of Biochemistry & Cell Biology. 36: 2541-50. PMID 15325591 DOI: 10.1016/j.biocel.2004.02.003 |
0.309 |
|
| 2004 |
Ravikumar B, Vacher C, Berger Z, Davies JE, Luo S, Oroz LG, Scaravilli F, Easton DF, Duden R, O'Kane CJ, Rubinsztein DC. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nature Genetics. 36: 585-95. PMID 15146184 DOI: 10.1038/Ng1362 |
0.361 |
|
| 2003 |
Sugars KL, Brown R, Cook LJ, Swartz J, Rubinsztein DC. Decreased cAMP response element-mediated transcription: an early event in exon 1 and full-length cell models of Huntington's disease that contributes to polyglutamine pathogenesis. The Journal of Biological Chemistry. 279: 4988-99. PMID 14627700 DOI: 10.1074/JBC.M310226200 |
0.322 |
|
| 2003 |
Rubinsztein DC, Carmichael J. Huntington's disease: molecular basis of neurodegeneration. Expert Reviews in Molecular Medicine. 5: 1-21. PMID 14585171 DOI: 10.1017/S1462399403006549 |
0.303 |
|
| 2003 |
Ravikumar B, Sarkar S, Berger Z, Rubinsztein DC. The roles of the ubiquitin-proteasome and autophagy-lysosome pathways in Huntington's disease and related conditions Clinical Neuroscience Research. 3: 141-148. DOI: 10.1016/S1566-2772(03)00056-2 |
0.34 |
|
| 2002 |
Ravikumar B, Duden R, Rubinsztein DC. Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Human Molecular Genetics. 11: 1107-17. PMID 11978769 DOI: 10.1093/HMG/11.9.1107 |
0.311 |
|
| 1997 |
Langenhoven E, Warnich L, Thiart R, Rubinsztein DC, van der Westhuyzen DR, Marais AD, Kotze MJ. Two novel point mutations causing receptor-negative familial hypercholesterolemia in a South African Indian homozygote. Atherosclerosis. 125: 111-9. PMID 8831933 DOI: 10.1016/0021-9150(96)05871-6 |
0.558 |
|
| 1993 |
Rubinsztein DC, Jialal I, Leitersdorf E, Coetzee GA, van der Westhuyzen DR. Identification of two new LDL-receptor mutations causing homozygous familial hypercholesterolemia in a South African of Indian origin Bba - Molecular Basis of Disease. 1182: 75-82. PMID 8347689 DOI: 10.1016/0925-4439(93)90156-U |
0.539 |
|
| 1993 |
Rubinsztein DC, Raal FJ, Seftel HC, Pilcher G, Coetzee GA, Van der Westhuyzen DR. Characterization of six patients who are double heterozygotes for familial hypercholesterolemia and familial defective apo B-100 Arteriosclerosis and Thrombosis. 13: 1076-1081. PMID 8318509 |
0.534 |
|
| 1990 |
Rubinsztein DC, Cohen JC, Berger GM, Van Der Westhuyzen DR, Coetzee GA, Gevers W. Chylomicron remnant clearance from the plasma is normal in familial hypercholesterolemic homozygotes with defined receptor defects Journal of Clinical Investigation. 86: 1306-1312. PMID 2212015 |
0.543 |
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