| Year |
Citation |
Score |
| 2024 |
Arnold MR, Cohn GM, Oxe KC, Elliott SN, Moore C, Laraia PV, Shekoohi S, Brownell D, Meshul CK, Witt SN, Larsen DH, Unni VK. Alpha-synuclein regulates nucleolar DNA double-strand break repair in melanoma. Biorxiv : the Preprint Server For Biology. PMID 38260370 DOI: 10.1101/2024.01.13.575526 |
0.577 |
|
| 2023 |
Gajendran N, Rajasekaran S, Witt SN. Knocking out alpha-synuclein in melanoma cells downregulates L1CAM and decreases motility. Scientific Reports. 13: 9243. PMID 37286800 DOI: 10.1038/s41598-023-36451-3 |
0.309 |
|
| 2022 |
Rajasekaran S, Patel D, Witt SN. α-synuclein and phosphoinositide-binding proteins: α-synuclein inhibits the association of PX- but not FYVE-containing proteins with vesicles in vivo. Biochemical and Biophysical Research Communications. 603: 7-12. PMID 35263697 DOI: 10.1016/j.bbrc.2022.01.101 |
0.58 |
|
| 2021 |
Rajasekaran S, Peterson PP, Liu Z, Robinson LC, Witt SN. α-Synuclein inhibits Snx3-retromer retrograde trafficking of the conserved membrane-bound proprotein convertase Kex2 in the secretory pathway of Saccharomyces cerevisiae. Human Molecular Genetics. PMID 34570221 DOI: 10.1093/hmg/ddab284 |
0.313 |
|
| 2021 |
Shekoohi S, Rajasekaran S, Patel D, Yang S, Liu W, Huang S, Yu X, Witt SN. Knocking out alpha-synuclein in melanoma cells dysregulates cellular iron metabolism and suppresses tumor growth. Scientific Reports. 11: 5267. PMID 33664298 DOI: 10.1038/s41598-021-84443-y |
0.673 |
|
| 2018 |
Patel D, Witt SN. Sorting Out the Role of α-Synuclein in Retromer-Mediated Endosomal Protein Sorting. Journal of Experimental Neuroscience. 12: 1179069518796215. PMID 30158827 DOI: 10.1177/1179069518796215 |
0.575 |
|
| 2018 |
Patel D, Xu C, Nagarajan S, Liu Z, Hemphill WO, Shi R, Uversky VN, Caldwell GA, Caldwell KA, Witt SN. Alpha-synuclein inhibits Snx3-retromer-mediated retrograde recycling of iron transporters in S. cerevisiae and C. elegans models of Parkinson's disease. Human Molecular Genetics. PMID 29452354 DOI: 10.1093/Hmg/Ddy059 |
0.532 |
|
| 2017 |
Patel D, Witt SN. Ethanolamine and Phosphatidylethanolamine: Partners in Health and Disease. Oxidative Medicine and Cellular Longevity. 2017: 4829180. PMID 28785375 DOI: 10.1155/2017/4829180 |
0.486 |
|
| 2016 |
Wang S, Zhang S, Xu C, Barron A, Galiano F, Patel D, Lee YJ, Caldwell GA, Caldwell KA, Witt SN. Chemical Compensation of Mitochondrial Phospholipid Depletion in Yeast and Animal Models of Parkinson's Disease. Plos One. 11: e0164465. PMID 27736935 DOI: 10.1371/Journal.Pone.0164465 |
0.537 |
|
| 2011 |
Liu X, Lee YJ, Liou LC, Ren Q, Zhang Z, Wang S, Witt SN. Alpha-synuclein functions in the nucleus to protect against hydroxyurea-induced replication stress in yeast. Human Molecular Genetics. 20: 3401-14. PMID 21642386 DOI: 10.1093/Hmg/Ddr246 |
0.312 |
|
| 2008 |
Liang J, Clark-Dixon C, Wang S, Flower TR, Williams-Hart T, Zweig R, Robinson LC, Tatchell K, Witt SN. Novel suppressors of alpha-synuclein toxicity identified using yeast. Human Molecular Genetics. 17: 3784-95. PMID 18772193 DOI: 10.1093/Hmg/Ddn276 |
0.682 |
|
| 2007 |
Flower TR, Clark-Dixon C, Metoyer C, Yang H, Shi R, Zhang Z, Witt SN. YGR198w (YPP1) targets A30P alpha-synuclein to the vacuole for degradation. The Journal of Cell Biology. 177: 1091-104. PMID 17576801 DOI: 10.1083/Jcb.200610071 |
0.667 |
|
| 2006 |
Witt SN, Flower TR. alpha-Synuclein, oxidative stress and apoptosis from the perspective of a yeast model of Parkinson's disease. Fems Yeast Research. 6: 1107-16. PMID 17156009 DOI: 10.1111/j.1567-1364.2006.00135.x |
0.681 |
|
| 2005 |
Flower TR, Chesnokova LS, Froelich CA, Dixon C, Witt SN. Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease. Journal of Molecular Biology. 351: 1081-100. PMID 16051265 DOI: 10.1016/J.Jmb.2005.06.060 |
0.677 |
|
| 2004 |
Flower TR, Witt SN. Mutational analysis of the yeast nucleotide exchange factor Mge1p Journal of the Chinese Chemical Society. 51: 1141-1146. |
0.656 |
|
| 2003 |
Chesnokova LS, Slepenkov SV, Protasevich II, Sehorn MG, Brouillette CG, Witt SN. Deletion of DnaK's lid strengthens binding to the nucleotide exchange factor, GrpE: a kinetic and thermodynamic analysis. Biochemistry. 42: 9028-40. PMID 12885236 DOI: 10.1021/Bi0346493 |
0.652 |
|
| 2002 |
Sehorn MG, Slepenkov SV, Witt SN. Characterization of two partially unfolded intermediates of the molecular chaperone DnaK at low pH. Biochemistry. 41: 8499-507. PMID 12081501 DOI: 10.1021/Bi025810X |
0.639 |
|
| 2001 |
Buczynski G, Slepenkov SV, Sehorn MG, Witt SN. Characterization of a lidless form of the molecular chaperone DnaK: Deletion of the lid increases peptide on- and off-rate constants Journal of Biological Chemistry. 276: 27231-27236. DOI: 10.1074/Jbc.M100237200 |
0.636 |
|
| 1990 |
Larsen RW, Li W, Copeland RA, Witt SN, Lou BS, Chan SI, Ondrias MR. Room temperature characterization of the dioxygen intermediates of cytochrome c oxidase by resonance Raman spectroscopy. Biochemistry. 29: 10135-40. PMID 2176863 DOI: 10.1021/Bi00495A018 |
0.579 |
|
| 1987 |
Witt SN, Chan SI. Evidence for a ferryl Fea3 in oxygenated cytochrome c oxidase Journal of Biological Chemistry. 262: 1446-1448. PMID 3027092 |
0.41 |
|
| 1986 |
Witt SN, Blair DF, Chan SI. Chemical and spectroscopic evidence for the formation of a ferryl Fe(α3) intermediate during turnover of cytochrome c oxidase Journal of Biological Chemistry. 261: 8104-8107. PMID 3013842 |
0.434 |
|
| 1986 |
BLAIR DF, WITT SN, CHAN SI. ChemInform Abstract: Mechanism of Cytochrome c Oxidase-Catalyzed Dioxygen Reduction at Low Temperatures. Chemischer Informationsdienst. 17. DOI: 10.1002/Chin.198613334 |
0.41 |
|
| 1985 |
Blair DF, Witt SN, Chan SI. Mechanism of cytochrome c oxidase-catalyzed dioxygen reduction at low temperatures. Evidence for two intermediates at the three-electron level and entropic promotion of the bond-breaking step Journal of the American Chemical Society. 107: 7389-7399. DOI: 10.1021/Ja00311A029 |
0.405 |
|
| Low-probability matches (unlikely to be authored by this person) |
| 2011 |
Lee YJ, Wang S, Slone SR, Yacoubian TA, Witt SN. Defects in very long chain fatty acid synthesis enhance alpha-synuclein toxicity in a yeast model of Parkinson's disease. Plos One. 6: e15946. PMID 21264320 DOI: 10.1371/Journal.Pone.0015946 |
0.295 |
|
| 2003 |
Slepenkov SV, Patchen B, Peterson KM, Witt SN. Importance of the D and E helices of the molecular chaperone DnaK for ATP binding and substrate release. Biochemistry. 42: 5867-76. PMID 12741845 DOI: 10.1021/bi034126v |
0.291 |
|
| 2013 |
Witt SN. Molecular chaperones, α-synuclein, and neurodegeneration. Molecular Neurobiology. 47: 552-60. PMID 22923346 DOI: 10.1007/s12035-012-8325-2 |
0.285 |
|
| 2014 |
Wang S, Zhang S, Liou LC, Ren Q, Zhang Z, Caldwell GA, Caldwell KA, Witt SN. Phosphatidylethanolamine deficiency disrupts α-synuclein homeostasis in yeast and worm models of Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America. 111: E3976-85. PMID 25201965 DOI: 10.1073/Pnas.1411694111 |
0.284 |
|
| 2014 |
Wang S, Witt SN. The Parkinson's Disease-Associated Protein α-Synuclein Disrupts Stress Signaling - A Possible Implication for Methamphetamine Use? Microbial Cell. 1: 131-132. PMID 25343141 |
0.263 |
|
| 2011 |
Lee YJ, Burlet E, Wang S, Xu B, Huang S, Galiano FJ, Witt SN. Triclabendazole protects yeast and mammalian cells from oxidative stress: identification of a potential neuroprotective compound. Biochemical and Biophysical Research Communications. 414: 205-8. PMID 21946065 DOI: 10.1016/j.bbrc.2011.09.057 |
0.261 |
|
| 2014 |
Witt SN. Lipid disequilibrium in biological membranes, a possible pathway to neurodegeneration. Communicative & Integrative Biology. 7: e993266. PMID 26480301 DOI: 10.4161/19420889.2014.993266 |
0.26 |
|
| 2021 |
Rajasekaran S, Witt SN. Trojan horses and tunneling nanotubes enable α-synuclein pathology to spread in Parkinson disease. Plos Biology. 19: e3001331. PMID 34284485 DOI: 10.1371/journal.pbio.3001331 |
0.255 |
|
| 1997 |
Witt SN, Galiano FJ, Slepenkov SV. Reactions of protamine with the molecular chaperone DnaK Cell Stress and Chaperones. 2: 110-118. PMID 9250402 DOI: 10.1379/1466-1268(1997)002<0110:ROPWTM>2.3.CO;2 |
0.248 |
|
| 2010 |
Witt SN. Hsp70 molecular chaperones and Parkinson's disease. Biopolymers. 93: 218-28. PMID 19768775 DOI: 10.1002/bip.21302 |
0.235 |
|
| 2012 |
Wang S, Xu B, Liou LC, Ren Q, Huang S, Luo Y, Zhang Z, Witt SN. α-Synuclein disrupts stress signaling by inhibiting polo-like kinase Cdc5/Plk2. Proceedings of the National Academy of Sciences of the United States of America. 109: 16119-24. PMID 22988096 DOI: 10.1073/Pnas.1206286109 |
0.221 |
|
| 2001 |
Buczynski G, Slepenkov SV, Sehorn MG, Witt SN. Characterization of a lidless form of the molecular chaperone DnaK: deletion of the lid increases peptide on- and off-rate constants. The Journal of Biological Chemistry. 276: 27231-6. PMID 11352903 DOI: 10.1074/jbc.M100237200 |
0.213 |
|
| 2001 |
Mally A, Witt SN. GrpE accelerates peptide binding and release from the high affinity state of DnaK Nature Structural Biology. 8: 254-257. PMID 11224572 DOI: 10.1038/85002 |
0.212 |
|
| 2002 |
Slepenkov SV, Witt SN. Kinetic analysis of interdomain coupling in a lidless variant of the molecular chaperone DnaK: DnaK's lid inhibits transition to the low affinity state. Biochemistry. 41: 12224-35. PMID 12356325 DOI: 10.1021/bi0263208 |
0.209 |
|
| 2005 |
Kedzierska S, Chesnokova LS, Witt SN, Zolkiewski M. Interactions within the ClpB/DnaK bi-chaperone system from Escherichia coli. Archives of Biochemistry and Biophysics. 444: 61-5. PMID 16289019 DOI: 10.1016/J.Abb.2005.10.005 |
0.208 |
|
| 2003 |
Slepenkov SV, Witt SN. Detection of a concerted conformational change in the ATPase domain of DnaK triggered by peptide binding. Febs Letters. 539: 100-4. PMID 12650934 DOI: 10.1016/S0014-5793(03)00207-2 |
0.206 |
|
| 1994 |
Witt SN, McConnell HM. Formation and dissociation of short-lived class II MHC-peptide complexes. Biochemistry. 33: 1861-8. PMID 8110789 DOI: 10.1021/Bi00173A032 |
0.198 |
|
| 1999 |
Farr CD, Witt SN. ATP lowers the activation enthalpy barriers to DnaK-peptide complex formation and dissociation Cell Stress and Chaperones. 4: 77-85. PMID 10547057 DOI: 10.1379/1466-1268(1999)004<0077:ALTAEB>2.3.CO;2 |
0.197 |
|
| 1995 |
Farr CD, Galiano FJ, Witt SN. Large activation energy barriers to chaperone-peptide complex formation and dissociation. Biochemistry. 34: 15574-82. PMID 7492560 |
0.194 |
|
| 2011 |
Witt SN. Protein Chaperones and Protection from Neurodegenerative Diseases Protein Chaperones and Protection From Neurodegenerative Diseases. DOI: 10.1002/9781118063903 |
0.191 |
|
| 2013 |
Wang S, Horn PJ, Liou LC, Muggeridge MI, Zhang Z, Chapman KD, Witt SN. A peroxisome biogenesis deficiency prevents the binding of alpha-synuclein to lipid droplets in lipid-loaded yeast. Biochemical and Biophysical Research Communications. 438: 452-6. PMID 23916615 DOI: 10.1016/J.Bbrc.2013.07.100 |
0.189 |
|
| 2012 |
Robbins D, Wittwer JA, Codarin S, Circu ML, Aw TY, Huang TT, Van Remmen H, Richardson A, Wang DB, Witt SN, Klein RL, Zhao Y. Isocitrate dehydrogenase 1 is downregulated during early skin tumorigenesis which can be inhibited by overexpression of manganese superoxide dismutase. Cancer Science. 103: 1429-33. PMID 22533343 DOI: 10.1111/J.1349-7006.2012.02317.X |
0.184 |
|
| 1999 |
Witt SN, Slepenkov SV. Unraveling the Kinetic Mechanism of the 70-kDa Molecular Chaperones Using Fluorescence Spectroscopic Methods Journal of Fluorescence. 9: 281-293. |
0.183 |
|
| 2011 |
Robbins DF, VanRemmen H, Richardson A, Wang DB, Witt SN, Klein RL, Zhao Y, Wittwer JA, Wang F, Codarin S, Shen X, Kevil CG, Circu ML, Aw TY, Huang TT. Abstract B59: Targeting metabolic enzymes in cancer prevention: Mechanistic insight into reciprocal regulation of isoforms of pyruvate kinase and isocitrate dehydrogenase in the early stage of cancer development Cancer Prevention Research. 4. DOI: 10.1158/1940-6207.Prev-11-B59 |
0.182 |
|
| 1998 |
Farr CD, Slepenkov SV, Witt SN. Visualization of a slow, ATP-induced structural transition in the bacterial molecular chaperone DnaK Journal of Biological Chemistry. 273: 9744-9748. PMID 9545310 DOI: 10.1074/jbc.273.16.9744 |
0.178 |
|
| 1992 |
Witt SN, McConnell HM. Antigenic peptide binding to the mouse major histocompatibility complex class II protein I-Ek. Peptide stabilization of the quarternary structure of I-Ek Journal of the American Chemical Society. 114: 3506-3511. DOI: 10.1021/Ja00035A052 |
0.174 |
|
| 1991 |
Witt SN, McConnell HM. A first-order reaction controls the binding of antigenic peptides to major histocompatibility complex class II molecules. Proceedings of the National Academy of Sciences of the United States of America. 88: 8164-8. PMID 1654561 |
0.173 |
|
| 2011 |
Lee YJ, Burlet E, Galiano F, Circu ML, Aw TY, Williams BJ, Witt SN. Phosphate and succinate use different mechanisms to inhibit sugar-induced cell death in yeast: insight into the Crabtree effect. The Journal of Biological Chemistry. 286: 20267-74. PMID 21515692 DOI: 10.1074/jbc.M110.209379 |
0.17 |
|
| 1998 |
Slepenkov SV, Witt SN. Peptide-induced conformational changes in the molecular chaperone DnaK Biochemistry. 37: 16749-16756. PMID 9843445 DOI: 10.1021/bi981738k |
0.168 |
|
| 2016 |
Zolkiewski M, Chesnokova LS, Witt SN. Reactivation of Aggregated Proteins by the ClpB/DnaK Bi-Chaperone System. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. 83: 28.10.1-28.10.18. PMID 26836408 DOI: 10.1002/0471140864.Ps2810S83 |
0.165 |
|
| 1997 |
Farr CD, Witt SN. Kinetic evidence for peptide-induced oligomerization of the molecular chaperone DnaK at heat shock temperatures Biochemistry. 36: 10793-10800. PMID 9271511 DOI: 10.1021/bi971082f |
0.161 |
|
| 1994 |
Liang MN, Witt SN, McConnell HM. Inhibition of class II MHC-peptide complex formation by protease inhibitors. Journal of Immunological Methods. 173: 127-31. PMID 8034980 DOI: 10.1016/0022-1759(94)90290-9 |
0.16 |
|
| 2005 |
Chesnokova LS, Witt SN. Switches, catapults, and chaperones: steady-state kinetic analysis of Hsp70-substrate interactions. Biochemistry. 44: 11224-33. PMID 16101306 DOI: 10.1021/bi050787b |
0.155 |
|
| 2004 |
Chesnokova LS, Slepenkov SV, Witt SN. The insect antimicrobial peptide, L-pyrrhocoricin, binds to and stimulates the ATPase activity of both wild-type and lidless DnaK. Febs Letters. 565: 65-9. PMID 15135054 DOI: 10.1016/j.febslet.2004.03.075 |
0.154 |
|
| 1993 |
Witt SN, Mcconnell HM. The kinetics of peptide reactions with class II major histocompatibility complex membrane proteins Accounts of Chemical Research. 26: 442-448. DOI: 10.1021/Ar00032A008 |
0.148 |
|
| 2013 |
Lee YJ, Shi R, Witt SN. The small molecule triclabendazole decreases the intracellular level of cyclic AMP and increases resistance to stress in Saccharomyces cerevisiae. Plos One. 8: e64337. PMID 23667708 DOI: 10.1371/journal.pone.0064337 |
0.148 |
|
| 1998 |
Slepenkov SV, Witt SN. Kinetics of the reactions of the Escherichia coli molecular chaperone DnaK with ATP: Evidence that a three-step reaction precedes ATP hydrolysis Biochemistry. 37: 1015-1024. PMID 9454592 DOI: 10.1021/bi9720484 |
0.136 |
|
| 2009 |
Witt SN. The Fink blueprint for Hsp70/Hsc70 molecular chaperones. Current Protein & Peptide Science. 10: 424-31. PMID 19538152 DOI: 10.2174/138920309789352047 |
0.125 |
|
| 2002 |
Slepenkov SV, Witt SN. The unfolding story of the Escherichia coli Hsp70 DnaK: is DnaK a holdase or an unfoldase? Molecular Microbiology. 45: 1197-206. PMID 12207689 DOI: 10.1046/j.1365-2958.2002.03093.x |
0.119 |
|
| 2009 |
Witt SN. Tethering creates unusual kinetics for ribosome-associated chaperones with nascent chains. Protein and Peptide Letters. 16: 631-4. PMID 19519521 DOI: 10.2174/092986609788490195 |
0.117 |
|
| 1992 |
Witt SN, Clark BR, McConnell HM. Mechanism of peptide release from major histocompatibility complex class II molecules Journal of the American Chemical Society. 114: 9680-9682. DOI: 10.1021/JA00050A070 |
0.1 |
|
| 2023 |
Lairmore TC, Abdulsattar J, De Benedetti A, Shi R, Huang S, Khalil MI, Witt SN. Loss of tumor suppressor menin expression in high grade cholangiocarcinomas. Bmc Research Notes. 16: 15. PMID 36782257 DOI: 10.1186/s13104-023-06282-6 |
0.076 |
|
| 1983 |
WITT SN, HAYES DM. ChemInform Abstract: KINETICS AND MECHANISM OF THE FORMATION OF VIOLET PEROXYCHROMATE IN AQUEOUS SOLUTION Chemischer Informationsdienst. 14. DOI: 10.1002/CHIN.198305034 |
0.065 |
|
| 1982 |
Witt SN, Hayes DM. Kinetics and mechanism of the formation of violet peroxychromate in aqueous solution Inorganic Chemistry. 21: 4014-4016. |
0.058 |
|
| 2011 |
Robbins D, Wittwer J, Wang F, Codarin S, Shen X, Kevil CG, Circu ML, Aw TY, Huang TT, VanRemmen H, Richardson A, Wang DB, Witt S, Klein RL, Zhao Y. Targeting Metabolic Enzymes in Cancer Prevention: Reciprocal Regulation of Isoforms of Pyruvate Kinase and Isocitrate Dehydrogenase in the Early Stage of Cancer Development Free Radical Biology and Medicine. 51. DOI: 10.1016/J.Freeradbiomed.2011.10.337 |
0.055 |
|
| 2011 |
Gross DS, Klein RL, Witt SN. Therapeutics: Harnessing the Power of Molecular and Pharmacological Chaperones Protein Chaperones and Protection From Neurodegenerative Diseases. 385-421. DOI: 10.1002/9781118063903.ch12 |
0.047 |
|
| 2003 |
Wirth S, Wieser A, Witt SN, Mutschler W, Reiser M. [Visualization of radiographically occult osteochondrosis dissecans of the talus using MRI]. Der Unfallchirurg. 106: 238-40. PMID 12658342 DOI: 10.1007/s00113-002-0542-0 |
0.023 |
|
| Hide low-probability matches. |