Donna M Wilcock - Publications

Affiliations: 
University of Kentucky, Lexington, KY 
Area:
Alzheimer's disease, vascular dementia, small vessel disease, microglia, neuroinflammation

128 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Foley KE, Wilcock DM. Soluble Biomarkers of Cerebrovascular Pathologies. Stroke. 55: 801-811. PMID 38527143 DOI: 10.1161/STROKEAHA.123.044172  0.31
2023 Winford E, Lutshumba J, Martin BJ, Wilcock DM, Jicha GA, Nikolajczyk BS, Stowe AM, Bachstetter AD. Terminally differentiated effector memory T cells associate with cognitive and AD-related biomarkers in an aging-based community cohort. Biorxiv : the Preprint Server For Biology. PMID 38077088 DOI: 10.1101/2023.11.27.568812  0.559
2023 Edwards NC, Lao PJ, Alshikho MJ, Ericsson OM, Rizvi B, Petersen ME, O'Bryant S, Flores-Aguilar L, Simoes S, Mapstone M, Tudorascu DL, Janelidze S, Hansson O, Handen BL, Christian BT, ... ... Wilcock DM, et al. Cerebrovascular disease drives Alzheimer plasma biomarker concentrations in adults with Down syndrome. Medrxiv : the Preprint Server For Health Sciences. PMID 38076904 DOI: 10.1101/2023.11.28.23298693  0.305
2023 Foley KE, Winder Z, Sudduth TL, Martin BJ, Nelson PT, Jicha GA, Harp JP, Weekman EM, Wilcock DM. Alzheimer's disease and inflammatory biomarkers positively correlate in plasma in the UK-ADRC cohort. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 38011580 DOI: 10.1002/alz.13485  0.756
2023 Niedowicz DM, Gollihue JL, Weekman EM, Phe P, Wilcock DM, Norris CM, Nelson PT. Using digital pathology to analyze the murine cerebrovasculature. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X231216142. PMID 37988134 DOI: 10.1177/0271678X231216142  0.694
2023 Bachstetter AD, Lutshumba J, Winford E, Abner EL, Martin BJ, Harp JP, Van Eldik LJ, Schmitt FA, Wilcock DM, Stowe AM, Jicha GA, Nikolajczyk BS. A blunted T17 cytokine signature in women with mild cognitive impairment: insights from inflammatory profiling of a community-based cohort of older adults. Brain Communications. 5: fcad259. PMID 37901041 DOI: 10.1093/braincomms/fcad259  0.501
2023 Foley KE, Weekman EM, Wilcock DM. Mechanisms of ARIA: is it time to focus on the unique immune environment of the neurovascular unit? Molecular Neurodegeneration. 18: 76. PMID 37858154 DOI: 10.1186/s13024-023-00667-8  0.656
2023 Bahrani AA, Abner EL, DeCarli CS, Barber JM, Sutton AC, Maillard P, Sandoval F, Arfanakis K, Yang YC, Evia AM, Schneider JA, Habes M, Franklin CG, Seshadri S, Satizabal CL, ... ... Wilcock DM, et al. Multi-Site Cross-Site Inter-Rater and Test-Retest Reliability and Construct Validity of the MarkVCID White Matter Hyperintensity Growth and Regression Protocol. Journal of Alzheimer's Disease : Jad. PMID 37840499 DOI: 10.3233/JAD-230629  0.555
2023 Gal J, Vary C, Gartner CA, Jicha GA, Abner EL, Ortega YS, Choucair I, Wilcock DM, Nelson R, Nelson P. Exploratory mass spectrometry of cerebrospinal fluid from persons with autopsy-confirmed LATE-NC. Research Square. PMID 37674727 DOI: 10.21203/rs.3.rs-3252238/v1  0.478
2023 Weekman EM, Johnson SN, Rogers CB, Sudduth TL, Xie K, Qiao Q, Fardo DW, Bottiglieri T, Wilcock DM. Atorvastatin rescues hyperhomocysteinemia-induced cognitive deficits and neuroinflammatory gene changes. Journal of Neuroinflammation. 20: 199. PMID 37658433 DOI: 10.1186/s12974-023-02883-x  0.767
2023 Ighodaro ET, Shahidehpour RK, Bachstetter AD, Abner EL, Nelson RS, Fardo DW, Shih AY, Grant RI, Neltner JH, Schmitt FA, Jicha GA, Kryscio RJ, Wilcock DM, Van Eldik LJ, Nelson PT. A neuropathologic feature of brain aging: multi-lumen vascular profiles. Acta Neuropathologica Communications. 11: 138. PMID 37641147 DOI: 10.1186/s40478-023-01638-2  0.494
2023 Ali DG, Bahrani AA, El Khouli RH, Gold BT, Jiang Y, Zachariou V, Wilcock DM, Jicha GA. White matter hyperintensities influence distal cortical β-amyloid accumulation in default mode network pathways. Brain and Behavior. e3209. PMID 37534614 DOI: 10.1002/brb3.3209  0.549
2023 Nelson RS, Abner EL, Jicha GA, Schmitt FA, Di J, Wilcock DM, Barber JM, Van Eldik LJ, Katsumata Y, Fardo DW, Nelson PT. Neurodegenerative pathologies associated with behavioral and psychological symptoms of dementia in a community-based autopsy cohort. Acta Neuropathologica Communications. 11: 89. PMID 37269007 DOI: 10.1186/s40478-023-01576-z  0.541
2023 Bauer CE, Zachariou V, Sudduth TL, Van Eldik LJ, Jicha GA, Nelson PT, Wilcock DM, Gold BT. Plasma TDP-43 levels are associated with neuroimaging measures of brain structure in limbic regions. Alzheimer's & Dementia (Amsterdam, Netherlands). 15: e12437. PMID 37266411 DOI: 10.1002/dad2.12437  0.432
2023 Kloske CM, Gearon MD, Weekman EM, Rogers C, Patel E, Bachstetter A, Nelson PT, Wilcock DM. Association between APOE genotype and microglial cell morphology. Journal of Neuropathology and Experimental Neurology. PMID 37087107 DOI: 10.1093/jnen/nlad031  0.75
2023 Estepp TG, Charnigo RJ, Abner EL, Jicha GA, Sudduth TL, Fardo DW, Wilcock DM. Associations of potential ADRD plasma biomarkers in cognitively normal volunteers. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 36840666 DOI: 10.1002/alz.13000  0.501
2023 Ali DG, Abner EL, Bahrani AA, El Khouli R, Gold BT, Jiang Y, Wilcock DM, Jicha GA. Amyloid-PET and White Matter Hyperintensities Have Independent Effects on Baseline Cognitive Function and Synergistic Effects on Longitudinal Executive Function. Brain Sciences. 13. PMID 36831761 DOI: 10.3390/brainsci13020218  0.593
2023 Sompol P, Gollihue JL, Weiss BE, Lin RL, Case SL, Kraner SD, Weekman EM, Gant JC, Rogers CB, Niedowicz DM, Sudduth TL, Powell DK, Lin AL, Nelson PT, Thibault O, ... Wilcock DM, et al. Targeting astrocyte signaling alleviates cerebrovascular and synaptic function deficits in a diet-based mouse model of small cerebral vessel disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 36746627 DOI: 10.1523/JNEUROSCI.1333-22.2023  0.731
2023 Verma N, Velmurugan GV, Winford E, Coburn H, Kotiya D, Leibold N, Radulescu L, Despa S, Chen KC, Van Eldik LJ, Nelson PT, Wilcock DM, Jicha GA, Stowe AM, Goldstein LB, et al. Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas. Communications Biology. 6: 2. PMID 36596993 DOI: 10.1038/s42003-022-04398-2  0.605
2022 Weekman EM, Winder Z, Rogers CB, Abner EL, Sudduth TL, Patel E, Dugan AJ, Fister SX, Wasek B, Nelson PT, Jicha GA, Bottiglieri T, Fardo DW, Wilcock DM. Genetic expression changes and pathologic findings associated with hyperhomocysteinemia in human autopsy brain tissue. Alzheimer's & Dementia (New York, N. Y.). 8: e12368. PMID 36514441 DOI: 10.1002/trc2.12368  0.778
2022 Foley KE, Wilcock DM. Vascular Considerations for Amyloid Immunotherapy. Current Neurology and Neuroscience Reports. 22: 709-719. PMID 36269539 DOI: 10.1007/s11910-022-01235-1  0.405
2022 Libecap TJ, Zachariou V, Bauer CE, Wilcock DM, Jicha GA, Raslau FD, Gold BT. Enlarged Perivascular Spaces Are Negatively Associated With Montreal Cognitive Assessment Scores in Older Adults. Frontiers in Neurology. 13: 888511. PMID 35847209 DOI: 10.3389/fneur.2022.888511  0.513
2022 Ali DG, Bahrani AA, Barber JM, El Khouli RH, Gold BT, Harp JP, Jiang Y, Wilcock DM, Jicha GA. Amyloid-PET Levels in the Precuneus and Posterior Cingulate Cortices Are Associated with Executive Function Scores in Preclinical Alzheimer's Disease Prior to Overt Global Amyloid Positivity. Journal of Alzheimer's Disease : Jad. PMID 35754276 DOI: 10.3233/JAD-220294  0.56
2022 Winder Z, Sudduth TL, Anderson S, Patel E, Neltner J, Martin BJ, Snyder KE, Abner EL, Jicha GA, Nelson PT, Wilcock DM. Examining the association between blood-based biomarkers and human post mortem neuropathology in the University of Kentucky Alzheimer's Disease Research Center autopsy cohort. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 35266629 DOI: 10.1002/alz.12639  0.587
2022 Seaks CE, Weekman EM, Sudduth TL, Xie K, Wasek B, Fardo DW, Johnson LA, Bottiglieri T, Wilcock DM. Apolipoprotein E ε4/4 genotype limits response to dietary induction of hyperhomocysteinemia and resulting inflammatory signaling. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X211069006. PMID 35023380 DOI: 10.1177/0271678X211069006  0.768
2021 Linton AE, Weekman EM, Wilcock DM. Pathologic sequelae of vascular cognitive impairment and dementia sheds light on potential targets for intervention. Cerebral Circulation - Cognition and Behavior. 2: 100030. PMID 36324710 DOI: 10.1016/j.cccb.2021.100030  0.731
2021 Linton AE, Weekman EM, Wilcock DM. Pathologic sequelae of vascular cognitive impairment and dementia sheds light on potential targets for intervention. Cerebral Circulation - Cognition and Behavior. 2: 100030. PMID 36324710 DOI: 10.1016/j.cccb.2021.100030  0.731
2021 Gal J, Katsumata Y, Zhu H, Srinivasan S, Chen J, Johnson LA, Wang WX, Golden LR, Wilcock DM, Jicha GA, Cykowski MD, Nelson PT. Apolipoprotein E proteinopathy is a major dementia-associated pathologic biomarker in individuals with or without the APOE epsilon 4 allele. The American Journal of Pathology. PMID 34954207 DOI: 10.1016/j.ajpath.2021.11.013  0.556
2021 Kloske CM, Dugan AJ, Weekman EM, Winder Z, Patel E, Nelson PT, Fardo DW, Wilcock DM. Inflammatory Pathways Are Impaired in Alzheimer Disease and Differentially Associated With Apolipoprotein E Status. Journal of Neuropathology and Experimental Neurology. PMID 34486652 DOI: 10.1093/jnen/nlab085  0.764
2021 Bahrani AA, Smith CD, Barber JM, Al-Janabi OM, Powell DK, Andersen AH, Ramey BD, Abner EL, Goldstein LB, Winder Z, Gold BT, Van Eldik L, Wilcock DM, Jicha GA. Development of a protocol to assess within-subject, regional white matter hyperintensity changes in aging and dementia. Journal of Neuroscience Methods. 360: 109270. PMID 34171312 DOI: 10.1016/j.jneumeth.2021.109270  0.504
2021 Sexton CE, Anstey KJ, Baldacci F, Barnum CJ, Barron AM, Blennow K, Brodaty H, Burnham S, Elahi FM, Götz J, Jeon YH, Koronyo-Hamaoui M, Landau SM, Lautenschlager NT, Laws SM, ... ... Wilcock D, et al. Alzheimer's disease research progress in Australia: The Alzheimer's Association International Conference Satellite Symposium in Sydney. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 34058063 DOI: 10.1002/alz.12380  0.306
2021 Gold BT, Shao X, Sudduth TL, Jicha GA, Wilcock DM, Seago ER, Wang DJJ. Water exchange rate across the blood-brain barrier is associated with CSF amyloid-β 42 in healthy older adults. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33949773 DOI: 10.1002/alz.12357  0.506
2021 Ly H, Verma N, Sharma S, Kotiya D, Despa S, Abner EL, Nelson PT, Jicha GA, Wilcock DM, Goldstein LB, Guerreiro R, Brás J, Hanson AJ, Craft S, Murray AJ, et al. The association of circulating amylin with β-amyloid in familial Alzheimer's disease. Alzheimer's & Dementia (New York, N. Y.). 7: e12130. PMID 33521236 DOI: 10.1002/trc2.12130  0.572
2021 Wilcock D, Jicha G, Blacker D, Albert MS, D'Orazio LM, Elahi FM, Fornage M, Hinman JD, Knoefel J, Kramer J, Kryscio RJ, Lamar M, Moghekar A, Prestopnik J, Ringman JM, et al. MarkVCID cerebral small vessel consortium: I. Enrollment, clinical, fluid protocols. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33480172 DOI: 10.1002/alz.12215  0.542
2020 Blevins BL, Vinters HV, Love S, Wilcock DM, Grinberg LT, Schneider JA, Kalaria RN, Katsumata Y, Gold BT, Wang DJJ, Ma SJ, Shade LMP, Fardo DW, Hartz AMS, Jicha GA, et al. Brain arteriolosclerosis. Acta Neuropathologica. PMID 33098484 DOI: 10.1007/s00401-020-02235-6  0.519
2020 Price BR, Sudduth TL, Weekman EM, Johnson S, Hawthorne D, Woolums A, Wilcock DM. Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition. Journal of Neuroinflammation. 17: 238. PMID 32795308 DOI: 10.1186/s12974-020-01915-0  0.811
2020 Carare RO, Aldea R, Agarwal N, Bacskai BJ, Bechman I, Boche D, Bu G, Bulters D, Clemens A, Counts SE, de Leon M, Eide PK, Fossati S, Greenberg SM, Hamel E, ... ... Wilcock D, et al. Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12053. PMID 32775596 DOI: 10.1002/Dad2.12053  0.306
2020 Winder Z, Wilcock D, Jicha GA. Diagnostic and Prognostic Laboratory Testing for Alzheimer Disease. Clinics in Laboratory Medicine. 40: 289-303. PMID 32718500 DOI: 10.1016/j.cll.2020.05.003  0.491
2020 Kloske CM, Wilcock DM. The Important Interface Between Apolipoprotein E and Neuroinflammation in Alzheimer's Disease. Frontiers in Immunology. 11: 754. PMID 32425941 DOI: 10.3389/fimmu.2020.00754  0.332
2020 Winder Z, Sudduth TL, Fardo D, Cheng Q, Goldstein LB, Nelson PT, Schmitt FA, Jicha GA, Wilcock DM. Hierarchical Clustering Analyses of Plasma Proteins in Subjects With Cardiovascular Risk Factors Identify Informative Subsets Based on Differential Levels of Angiogenic and Inflammatory Biomarkers. Frontiers in Neuroscience. 14: 84. PMID 32116527 DOI: 10.3389/Fnins.2020.00084  0.437
2020 Sompol P, Edelmann SE, Lin R, Gant CC, Kraner SD, Weiss BE, Farr ND, Gollihue JL, Thibault O, Wilcock DM, Norris CM. Astrocyte activation and neurovascular function in a diet‐based model of vascular contributions to cognitive impairment and dementia (VCID) Alzheimer's & Dementia. 16. DOI: 10.1002/alz.043618  0.318
2020 Weekman EM, Lee T, Price BR, Woolums AE, Hawthorne D, IV CES, Wilcock DM. Hyperhomocysteinemia as a model of VCID Alzheimer's & Dementia. 16. DOI: 10.1002/alz.039888  0.739
2019 Weekman EM, Sudduth TL, Price BR, Woolums AE, Hawthorne D, Seaks CE, Wilcock DM. Time course of neuropathological events in hyperhomocysteinemic amyloid depositing mice reveals early neuroinflammatory changes that precede amyloid changes and cerebrovascular events. Journal of Neuroinflammation. 16: 284. PMID 31888650 DOI: 10.1186/s12974-019-1685-z  0.816
2019 Bahrani AA, Al-Janabi OM, Abner EL, Bardach SH, Kryscio RJ, Wilcock DM, Smith CD, Jicha GA. Post-acquisition Processing Confounds in Brain Volumetric Quantification of White Matter Hyperintensities. Journal of Neuroscience Methods. 108391. PMID 31408649 DOI: 10.1016/J.Jneumeth.2019.108391  0.413
2019 Al-Janabi OM, Bauer CE, Goldstein LB, Murphy RR, Bahrani AA, Smith CD, Wilcock DM, Gold BT, Jicha GA. White Matter Hyperintensity Regression: Comparison of Brain Atrophy and Cognitive Profiles with Progression and Stable Groups. Brain Sciences. 9. PMID 31330933 DOI: 10.3390/Brainsci9070170  0.529
2019 Alber J, Alladi S, Bae HJ, Barton DA, Beckett LA, Bell JM, Berman SE, Biessels GJ, Black SE, Bos I, Bowman GL, Brai E, Brickman AM, Callahan BL, Corriveau RA, ... ... Wilcock DM, et al. White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities. Alzheimer's & Dementia (New York, N. Y.). 5: 107-117. PMID 31011621 DOI: 10.1016/J.Trci.2019.02.001  0.808
2019 Price BR, Sudduth TL, Weekman EM, Woolums A, Hawthorne D, Rosenthal A, Wilcock DM. THERAPEUTIC TARGETING OF TREM2 BY AN ACTIVATING ANTIBODY AMELIORATES AMYLOID-BETA DEPOSITION AND IMPROVES COGNITION IN THE 5XFAD MODEL OF ALZHEIMER’S DISEASE Alzheimer's & Dementia. 15: P214. DOI: 10.1016/j.jalz.2019.06.4559  0.799
2018 Price BR, Wilcock DM, Weekman EM. Hyperhomocysteinemia as a Risk Factor for Vascular Contributions to Cognitive Impairment and Dementia. Frontiers in Aging Neuroscience. 10: 350. PMID 30429785 DOI: 10.3389/fnagi.2018.00350  0.793
2018 Al-Janabi OM, Brown CA, Bahrani AA, Abner EL, Barber JM, Gold BT, Goldstein LB, Murphy RR, Nelson PT, Johnson NF, Shaw LM, Smith CD, Trojanowski JQ, Wilcock DM, Jicha GA. Distinct White Matter Changes Associated with Cerebrospinal Fluid Amyloid-β1 - 42 and Hypertension. Journal of Alzheimer's Disease : Jad. PMID 30400099 DOI: 10.3233/Jad-180663  0.528
2018 Abner EL, Neltner JH, Jicha GA, Patel E, Anderson SL, Wilcock DM, Van Eldik LJ, Nelson PT. Diffuse Amyloid-β Plaques, Neurofibrillary Tangles, and the Impact of APOE in Elderly Persons' Brains Lacking Neuritic Amyloid Plaques. Journal of Alzheimer's Disease : Jad. PMID 30040735 DOI: 10.3233/Jad-180514  0.591
2018 Al-Janabi OM, Panuganti P, Abner EL, Bahrani AA, Murphy R, Bardach SH, Caban-Holt A, Nelson PT, Gold BT, Smith CD, Wilcock DM, Jicha GA. Global Cerebral Atrophy Detected by Routine Imaging: Relationship with Age, Hippocampal Atrophy, and White Matter Hyperintensities. Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging. PMID 29314393 DOI: 10.1111/Jon.12494  0.543
2018 Nelson PT, Abner EL, Patel E, Anderson S, Wilcock DM, Kryscio RJ, Van Eldik LJ, Jicha GA, Gal Z, Nelson RS, Nelson BG, Gal J, Azam MT, Fardo DW, Cykowski MD. The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases. Journal of Neuropathology and Experimental Neurology. 77: 2-20. PMID 29186501 DOI: 10.1093/Jnen/Nlx099  0.523
2017 Price BR, Norris CM, Sompol P, Wilcock DM. An emerging role of astrocytes in vascular contributions to cognitive impairment and dementia (VCID). Journal of Neurochemistry. PMID 29222909 DOI: 10.1111/Jnc.14273  0.807
2017 Weekman EM, Woolums AE, Sudduth TL, Wilcock DM. Hyperhomocysteinemia-Induced Gene Expression Changes in the Cell Types of the Brain. Asn Neuro. 9: 1759091417742296. PMID 29198136 DOI: 10.1177/1759091417742296  0.748
2017 Price BR, Sudduth TL, Weekman EM, Wilcock DM, Woolums A. [P1–004]: ASTROCYTE RESPONSE TO HYPERHOMOCYSTEINEMIA (HHCY) Alzheimer's & Dementia. 13. DOI: 10.1016/j.jalz.2017.06.071  0.751
2017 Price BR, Sudduth TL, Weekman EM, Wilcock DM, Woolums A. [P1–198]: ASTROCYTE RESPONSE TO HYPERHOMOCYSTEINEMIA (HHCY) Alzheimer's & Dementia. 13. DOI: 10.1016/j.jalz.2017.06.018  0.751
2016 Sudduth TL, Weekman EM, Price BR, Gooch JL, Woolums A, Norris CM, Wilcock DM. Time-course of glial changes in the hyperhomocysteinemia model of vascular cognitive impairment and dementia (VCID). Neuroscience. PMID 27890830 DOI: 10.1016/J.Neuroscience.2016.11.024  0.807
2016 Davis PR, Giannini G, Rudolph K, Calloway N, Royer CM, Beckett TL, Murphy MP, Bresch F, Pagani D, Platt T, Wang X, Donovan AS, Sudduth TL, Lou W, Abner E, ... ... Wilcock DM, et al. Aβ vaccination in combination with behavioral enrichment in aged beagles: effects on cognition, Aβ, and microhemorrhages. Neurobiology of Aging. 49: 86-99. PMID 27776266 DOI: 10.1016/J.Neurobiolaging.2016.09.007  0.36
2016 Weekman EM, Sudduth TL, Caverly CN, Kopper TJ, Phillips OW, Powell DK, Wilcock DM. Reduced Efficacy of Anti-Aβ Immunotherapy in a Mouse Model of Amyloid Deposition and Vascular Cognitive Impairment Comorbidity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 9896-907. PMID 27656027 DOI: 10.1523/JNEUROSCI.1762-16.2016  0.781
2016 Gooch J, Wilcock DM. Animal Models of Vascular Cognitive Impairment and Dementia (VCID). Cellular and Molecular Neurobiology. 36: 233-9. PMID 26988696 DOI: 10.1007/s10571-015-0286-3  0.315
2016 Hainsworth AH, Yeo NE, Weekman EM, Wilcock DM. Homocysteine, hyperhomocysteinemia and vascular contributions to cognitive impairment and dementia (VCID). Biochimica Et Biophysica Acta. 1862: 1008-17. PMID 26689889 DOI: 10.1016/j.bbadis.2015.11.015  0.723
2016 Head E, Lott IT, Wilcock DM, Lemere CA. Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology. Current Alzheimer Research. 13: 18-29. PMID 26651341 DOI: 10.2174/1567205012666151020114607  0.317
2016 Wilcock DM, Sudduth TL, Weekman EM, Pleiss MM, Woolums A, Norris CM. Neurovascular Astrocyte Dysfunction As A Key Mediator Of Vascular Cognitive Impairment Alzheimers & Dementia. 12: 270. DOI: 10.1016/J.Jalz.2016.06.489  0.732
2015 Weekman EM, Wilcock DM. Matrix Metalloproteinase in Blood-Brain Barrier Breakdown in Dementia. Journal of Alzheimer's Disease : Jad. 49: 893-903. PMID 26599057 DOI: 10.3233/JAD-150759  0.735
2015 Wilcock DM, Schmitt FA, Head E. Cerebrovascular contributions to aging and Alzheimer disease in down syndrome. Biochimica Et Biophysica Acta. PMID 26593849 DOI: 10.1016/J.Bbadis.2015.11.007  0.377
2015 Wilcock DM, Hurban J, Helman AM, Sudduth TL, McCarty KL, Beckett TL, Ferrell JC, Murphy MP, Abner EL, Schmitt FA, Head E. Down syndrome individuals with Alzheimer's disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer's disease. Neurobiology of Aging. 36: 2468-74. PMID 26103884 DOI: 10.1016/J.Neurobiolaging.2015.05.016  0.311
2015 Latta CH, Sudduth TL, Weekman EM, Brothers HM, Abner EL, Popa GJ, Mendenhall MD, Gonzalez-Oregon F, Braun K, Wilcock DM. Determining the role of IL-4 induced neuroinflammation in microglial activity and amyloid-β using BV2 microglial cells and APP/PS1 transgenic mice. Journal of Neuroinflammation. 12: 41. PMID 25885682 DOI: 10.1186/S12974-015-0243-6  0.739
2015 Snyder HM, Corriveau RA, Craft S, Faber JE, Greenberg SM, Knopman D, Lamb BT, Montine TJ, Nedergaard M, Schaffer CB, Schneider JA, Wellington C, Wilcock DM, Zipfel GJ, Zlokovic B, et al. Vascular contributions to cognitive impairment and dementia including Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 710-717. PMID 25510382 DOI: 10.1016/J.Jalz.2014.10.008  0.328
2014 Latta CH, Brothers HM, Wilcock DM. Neuroinflammation in Alzheimer's disease; A source of heterogeneity and target for personalized therapy. Neuroscience. PMID 25286385 DOI: 10.1016/j.neuroscience.2014.09.061  0.318
2014 Weekman EM, Sudduth TL, Abner EL, Popa GJ, Mendenhall MD, Brothers HM, Braun K, Greenstein A, Wilcock DM. Transition from an M1 to a mixed neuroinflammatory phenotype increases amyloid deposition in APP/PS1 transgenic mice. Journal of Neuroinflammation. 11: 127. PMID 25062954 DOI: 10.1186/1742-2094-11-127  0.731
2014 Colton CA, Wilson JG, Everhart A, Wilcock DM, Puoliväli J, Heikkinen T, Oksman J, Jääskeläinen O, Lehtimäki K, Laitinen T, Vartiainen N, Vitek MP. mNos2 deletion and human NOS2 replacement in Alzheimer disease models. Journal of Neuropathology and Experimental Neurology. 73: 752-69. PMID 25003233 DOI: 10.1097/NEN.0000000000000094  0.61
2014 Sudduth TL, Weekman EM, Brothers HM, Braun K, Wilcock DM. β-amyloid deposition is shifted to the vasculature and memory impairment is exacerbated when hyperhomocysteinemia is induced in APP/PS1 transgenic mice. Alzheimer's Research & Therapy. 6: 32. PMID 24991237 DOI: 10.1186/alzrt262  0.779
2014 Niedowicz DM, Reeves VL, Platt TL, Kohler K, Beckett TL, Powell DK, Lee TL, Sexton TR, Song ES, Brewer LD, Latimer CS, Kraner SD, Larson KL, Ozcan S, Norris CM, ... ... Wilcock DM, et al. Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia. Acta Neuropathologica Communications. 2: 64. PMID 24916066 DOI: 10.1186/2051-5960-2-64  0.305
2014 Wilcock DM. Neuroinflammatory phenotypes and their roles in Alzheimer's disease. Neuro-Degenerative Diseases. 13: 183-5. PMID 24021538 DOI: 10.1159/000354228  0.332
2013 Brothers HM, Wilcock DM. Are inflammatory profiles the key to personalized Alzheimer's treatment? Neurodegenerative Disease Management. 3: 343-351. PMID 25614767 DOI: 10.2217/nmt.13.40  0.319
2013 Nelson PT, Pious NM, Jicha GA, Wilcock DM, Fardo DW, Estus S, Rebeck GW. APOE-ε2 and APOE-ε4 correlate with increased amyloid accumulation in cerebral vasculature. Journal of Neuropathology and Experimental Neurology. 72: 708-15. PMID 23771217 DOI: 10.1097/Nen.0B013E31829A25B9  0.536
2013 Carty N, Nash KR, Brownlow M, Cruite D, Wilcock D, Selenica ML, Lee DC, Gordon MN, Morgan D. Intracranial injection of AAV expressing NEP but not IDE reduces amyloid pathology in APP+PS1 transgenic mice. Plos One. 8: e59626. PMID 23555730 DOI: 10.1371/Journal.Pone.0059626  0.672
2013 Sudduth TL, Powell DK, Smith CD, Greenstein A, Wilcock DM. Induction of hyperhomocysteinemia models vascular dementia by induction of cerebral microhemorrhages and neuroinflammation. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 33: 708-15. PMID 23361394 DOI: 10.1038/jcbfm.2013.1  0.317
2012 Ridnour LA, Dhanapal S, Hoos M, Wilson J, Lee J, Cheng RY, Brueggemann EE, Hines HB, Wilcock DM, Vitek MP, Wink DA, Colton CA. Nitric oxide-mediated regulation of β-amyloid clearance via alterations of MMP-9/TIMP-1. Journal of Neurochemistry. 123: 736-49. PMID 23016931 DOI: 10.1111/Jnc.12028  0.513
2012 Wilcock DM. A changing perspective on the role of neuroinflammation in Alzheimer's disease. International Journal of Alzheimer's Disease. 2012: 495243. PMID 22844636 DOI: 10.1155/2012/495243  0.346
2012 Sudduth TL, Wilson JG, Everhart A, Colton CA, Wilcock DM. Lithium treatment of APPSwDI/NOS2-/- mice leads to reduced hyperphosphorylated tau, increased amyloid deposition and altered inflammatory phenotype. Plos One. 7: e31993. PMID 22347510 DOI: 10.1371/journal.pone.0031993  0.604
2012 Vitek MP, Christensen DJ, Wilcock D, Davis J, Van Nostrand WE, Li FQ, Colton CA. APOE-mimetic peptides reduce behavioral deficits, plaques and tangles in Alzheimer's disease transgenics. Neuro-Degenerative Diseases. 10: 122-6. PMID 22326991 DOI: 10.1159/000334914  0.601
2011 Wilcock DM, Zhao Q, Morgan D, Gordon MN, Everhart A, Wilson JG, Lee JE, Colton CA. Diverse inflammatory responses in transgenic mouse models of Alzheimer's disease and the effect of immunotherapy on these responses. Asn Neuro. 3: 249-58. PMID 21995345 DOI: 10.1042/An20110018  0.737
2011 Wilcock DM, Morgan D, Gordon MN, Taylor TL, Ridnour LA, Wink DA, Colton CA. Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence. Journal of Neuroinflammation. 8: 115. PMID 21906275 DOI: 10.1186/1742-2094-8-115  0.699
2010 Abisambra JF, Blair LJ, Hill SE, Jones JR, Kraft C, Rogers J, Koren J, Jinwal UK, Lawson L, Johnson AG, Wilcock D, O'Leary JC, Jansen-West K, Muschol M, Golde TE, et al. Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15374-82. PMID 21084594 DOI: 10.1523/Jneurosci.3155-10.2010  0.543
2010 Wilcock DM. The usefulness and challenges of transgenic mouse models in the study of Alzheimer's disease. Cns & Neurological Disorders Drug Targets. 9: 386-94. PMID 20522016  0.367
2010 Colton C, Wilcock DM. Assessing activation states in microglia. Cns & Neurological Disorders Drug Targets. 9: 174-91. PMID 20205642  0.526
2010 Wu J, Yoo S, Wilcock D, Lytle JM, Leung PY, Colton CA, Wrathall JR. Interaction of NG2(+) glial progenitors and microglia/macrophages from the injured spinal cord. Glia. 58: 410-22. PMID 19780197 DOI: 10.1002/Glia.20932  0.435
2009 Wilcock DM, Gharkholonarehe N, Van Nostrand WE, Davis J, Vitek MP, Colton CA. Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 7957-65. PMID 19553436 DOI: 10.1523/JNEUROSCI.1339-09.2009  0.627
2009 Wilcock DM, Vitek MP, Colton CA. Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease. Neuroscience. 159: 1055-69. PMID 19356689 DOI: 10.1016/j.neuroscience.2009.01.023  0.597
2009 Wilcock DM, Colton CA. Immunotherapy, vascular pathology, and microhemorrhages in transgenic mice. Cns & Neurological Disorders Drug Targets. 8: 50-64. PMID 19275636 DOI: 10.2174/187152709787601858  0.633
2009 Vitek MP, Christensen DJ, Wilcock D, Oddo J, Gharkholonarehe N, Ohkubo N, Toku K, Van Nostrand WE, Li F, Colton CA. O2-04-05: Novel mechanism where ApoE mimetics activate PP2A activity and reduce Alzheimer's pathology in three different transgenic models Alzheimer's & Dementia. 5: P111-P111. DOI: 10.1016/j.jalz.2009.05.347  0.54
2009 Colton CA, Vitek MP, Wilcock D. O1-03-04: Testing the amyloid cascade hypothesis in a novel mouse model of Alzheimer's disease that shows complete disease progression Alzheimer's & Dementia. 5: P82-P83. DOI: 10.1016/j.jalz.2009.05.208  0.558
2008 Colton CA, Wilcock DM, Wink DA, Davis J, Van Nostrand WE, Vitek MP. The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP. Journal of Alzheimer's Disease : Jad. 15: 571-87. PMID 19096157 DOI: 10.3233/Jad-2008-15405  0.616
2008 Wilcock DM, Colton CA. Anti-amyloid-beta immunotherapy in Alzheimer's disease: relevance of transgenic mouse studies to clinical trials. Journal of Alzheimer's Disease : Jad. 15: 555-69. PMID 19096156  0.608
2008 Wilcock DM, Lewis MR, Van Nostrand WE, Davis J, Previti ML, Gharkholonarehe N, Vitek MP, Colton CA. Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 1537-45. PMID 18272675 DOI: 10.1523/JNEUROSCI.5066-07.2008  0.606
2008 Colton CA, Wilcock DM, Davis J, Van Nostrand W, Vitek MP. P1-050: Progression to a full spectrum of Alzheimer's-like pathology in animal models of amyloid deposition by reduction in NOS2 Alzheimer's & Dementia. 4: T220-T220. DOI: 10.1016/j.jalz.2008.05.635  0.579
2008 Wilcock DM, Vitek MP, Colton CA. P4-291: Cerebral amyloid angiopathy results in neurovascular unit disruption in transgenic mouse models of Alzheimer's disease Alzheimer's & Dementia. 4: T756-T757. DOI: 10.1016/j.jalz.2008.05.2360  0.588
2007 Wilcock DM, Jantzen PT, Li Q, Morgan D, Gordon MN. Amyloid-beta vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid. Neuroscience. 144: 950-60. PMID 17137722 DOI: 10.1016/J.Neuroscience.2006.10.020  0.596
2007 Karlnoski R, Wilcock D, Dickey C, Ronan V, Gordon MN, Zhang W, Morgan D, Taglialatela G. Up-regulation of Bcl-2 in APP transgenic mice is associated with neuroprotection Neurobiology of Disease. 25: 179-188. PMID 17067805 DOI: 10.1016/J.Nbd.2006.09.007  0.704
2006 Alamed J, Wilcock DM, Diamond DM, Gordon MN, Morgan D. Two-day radial-arm water maze learning and memory task; robust resolution of amyloid-related memory deficits in transgenic mice. Nature Protocols. 1: 1671-9. PMID 17487150 DOI: 10.1038/Nprot.2006.275  0.513
2006 Wilcock DM, Gordon MN, Morgan D. Quantification of cerebral amyloid angiopathy and parenchymal amyloid plaques with Congo red histochemical stain. Nature Protocols. 1: 1591-5. PMID 17406451 DOI: 10.1038/Nprot.2006.277  0.619
2006 Wilcock DM, Alamed J, Gottschall PE, Grimm J, Rosenthal A, Pons J, Ronan V, Symmonds K, Gordon MN, Morgan D. Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 5340-6. PMID 16707786 DOI: 10.1523/Jneurosci.0695-06.2006  0.614
2006 Carty NC, Wilcock DM, Rosenthal A, Grimm J, Pons J, Ronan V, Gottschall PE, Gordon MN, Morgan D. Intracranial administration of deglycosylated C-terminal-specific anti-Abeta antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice. Journal of Neuroinflammation. 3: 11. PMID 16686956 DOI: 10.1186/1742-2094-3-11  0.589
2006 Al-Janabi OM, Ali Bahrani A, Murphy RR, Nelson PT, Trojanowski JQ, Smith CD, Shaw LM, Wilcock DM, Jicha GA. P1-398: PARIETAL LOBE CEREBRAL MICROBLEEDS ARE ASSOCIATED WITH LOWER CEREBROSPINAL FLUID BETA AMYLOID 1-42 IN PATIENTS WITH SPORADIC AD Alzheimer's & Dementia. 14: P454-P455. DOI: 10.1016/J.Jalz.2018.06.406  0.512
2006 Sudduth TL, Jicha GA, Nelson P, Abner EL, Wilcock DM. F4-06-04: INSIGHTS FROM FLUID BIOMARKERS OF NEUROINFLAMMATION Alzheimer's & Dementia. 14: P1392-P1392. DOI: 10.1016/J.Jalz.2018.06.2887  0.385
2006 Bahrani AA, Al-Janabi OM, Wilcock DM, Smith CD, Jicha GA. IC-P-152: WMH LONGITUDINAL STUDY ANALYSIS USING DIFFERENT PROTOCOLS Alzheimer's & Dementia. 14: P129-P130. DOI: 10.1016/j.jalz.2018.06.2219  0.386
2006 Bahrani AA, Al-Janabi OM, Wilcock DM, Smith CD, Jicha GA. IC-P-115: ELIMINATING THE SOURCES OF VARIABILITY IN A SEMI-AUTOMATED WMH QUANTIFICATION METHOD Alzheimer's & Dementia. 14: P99-P99. DOI: 10.1016/j.jalz.2018.06.2181  0.383
2006 Price BR, Sudduth TL, Dickey CA, Wilcock DM. P3-205: AN EMERGING ROLE FOR HSP27 IN VASCULAR COGNITIVE IMPAIRMENT AND DEMENTIA (VCID) Alzheimer's & Dementia. 14: P1146-P1146. DOI: 10.1016/j.jalz.2018.06.1564  0.794
2006 Al-Janabi OM, Panuganti P, Murphy RR, Nelson PT, Smith CD, Wilcock DM, Jicha GA. P2-380: MODERATE-SEVERE LEFT MEDIAL TEMPORAL LOBE ATROPHY IS ASSOCIATED WITH WORSE COGNITIVE TESTING SCORES IN A COMMUNITY BASED ELDERLY COHORT Alzheimer's & Dementia. 14: P842-P842. DOI: 10.1016/j.jalz.2018.06.1071  0.464
2006 Lutz L, Mercer M, Freeman M, Ronan V, Wilcock D, Herber D, Gordon M, Morgan D. Phenotyping the microglial response using different activators in mouse CNS Experimental Neurology. 198: 579. DOI: 10.1016/J.Expneurol.2006.02.067  0.529
2005 Morgan D, Gordon MN, Tan J, Wilcock D, Rojiani AM. Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics. Journal of Neuropathology and Experimental Neurology. 64: 743-53. PMID 16141783 DOI: 10.1097/01.Jnen.0000178444.33972.E0  0.636
2005 Gasparini L, Ongini E, Wilcock D, Morgan D. Activity of flurbiprofen and chemically related anti-inflammatory drugs in models of Alzheimer's disease. Brain Research. Brain Research Reviews. 48: 400-8. PMID 15850679 DOI: 10.1016/J.Brainresrev.2004.12.029  0.314
2005 Dickey CA, Gordon MN, Wilcock DM, Herber DL, Freeman MJ, Morgan D. Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice. Bmc Neuroscience. 6: 7. PMID 15689237 DOI: 10.1186/1471-2202-6-7  0.709
2004 Wilcock DM, Rojiani A, Rosenthal A, Subbarao S, Freeman MJ, Gordon MN, Morgan D. Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage. Journal of Neuroinflammation. 1: 24. PMID 15588287 DOI: 10.1186/1742-2094-1-24  0.65
2004 Wilcock DM, Rojiani A, Rosenthal A, Levkowitz G, Subbarao S, Alamed J, Wilson D, Wilson N, Freeman MJ, Gordon MN, Morgan D. Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 6144-51. PMID 15240806 DOI: 10.1523/Jneurosci.1090-04.2004  0.601
2004 Wilcock DM, Munireddy SK, Rosenthal A, Ugen KE, Gordon MN, Morgan D. Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration. Neurobiology of Disease. 15: 11-20. PMID 14751766 DOI: 10.1016/J.Nbd.2003.09.015  0.593
2004 Wilcock DM, Rojiani A, Rosenthal A, Alamed J, Wilson D, Wilson N, Freeman MJ, Gordon MN, Morgan D. P4-366 Passive immunization with anti-Aβ antibodies reduces amyloid burden while producing a brief activation of microglia in a transgenic mouse model of amyloid deposition Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81924-9  0.615
2003 Wilcock DM, DiCarlo G, Henderson D, Jackson J, Clarke K, Ugen KE, Gordon MN, Morgan D. Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 3745-51. PMID 12736345  0.608
2003 Boyett KW, DiCarlo G, Jantzen PT, Jackson J, O'Leary C, Wilcock D, Morgan D, Gordon MN. Increased fibrillar beta-amyloid in response to human clq injections into hippocampus and cortex of APP+PS1 transgenic mice. Neurochemical Research. 28: 83-93. PMID 12587666 DOI: 10.1023/A:1021600212829  0.612
2003 Morgan D, Jantzen P, Wilcock D, DiCarlo G, Ugen K, Gordon M. The Association of Microglial Activation and Amyloid Reduction in APP+PS1 Transgenic Mice Current Medicinal Chemistry-Immunology, Endocrine & Metabolic Agents. 3: 27-32. DOI: 10.2174/1568013033358680  0.638
2003 Wilcock DM, DiCarlo G, Henderson D, Jackson J, Clarke K, Ugen KE, Gordon MN, Morgan D. Intracranially Administered Anti-Αβ Antibodies Reduce β-Amyloid Deposition by Mechanisms Both Independent of and Associated with Microglial Activation The Journal of Neuroscience. 23: 3745-3751. DOI: 10.1523/Jneurosci.23-09-03745.2003  0.607
2002 Gordon MN, Holcomb LA, Jantzen PT, DiCarlo G, Wilcock D, Boyett KW, Connor K, Melachrino J, O'Callaghan JP, Morgan D. Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse. Experimental Neurology. 173: 183-95. PMID 11822882 DOI: 10.1006/Exnr.2001.7754  0.607
2001 Arendash GW, Gordon MN, Diamond DM, Austin LA, Hatcher JM, Jantzen P, DiCarlo G, Wilcock D, Morgan D. Behavioral assessment of Alzheimer's transgenic mice following long-term Abeta vaccination: task specificity and correlations between Abeta deposition and spatial memory. Dna and Cell Biology. 20: 737-44. PMID 11788052 DOI: 10.1089/10445490152717604  0.593
2001 Wilcock DM, Gordon MN, Ugen KE, Gottschall PE, DiCarlo G, Dickey C, Boyett KW, Jantzen PT, Connor KE, Melachrino J, Hardy J, Morgan D. Number of Abeta inoculations in APP+PS1 transgenic mice influences antibody titers, microglial activation, and congophilic plaque levels. Dna and Cell Biology. 20: 731-6. PMID 11788051 DOI: 10.1089/10445490152717596  0.727
2001 DiCarlo G, Wilcock D, Henderson D, Gordon M, Morgan D. Intrahippocampal LPS injections reduce Abeta load in APP+PS1 transgenic mice. Neurobiology of Aging. 22: 1007-12. PMID 11755009 DOI: 10.1016/S0197-4580(01)00292-5  0.582
2001 Morgan D, Diamond DM, Gottschall PE, Ugen KE, Dickey C, Hardy J, Duff K, Jantzen P, DiCarlo G, Wilcock D, Connor K, Hatcher J, Hope C, Gordon M, Arendash GW. Erratum: correction: Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease Nature. 412: 660-660. DOI: 10.1038/35088102  0.688
2000 Morgan D, Diamond DM, Gottschall PE, Ugen KE, Dickey C, Hardy J, Duff K, Jantzen P, DiCarlo G, Wilcock D, Connor K, Hatcher J, Hope C, Gordon M, Arendash GW. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature. 408: 982-5. PMID 11140686 DOI: 10.1038/35050116  0.708
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