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Kevin Michael O'Shaughnessy, MB, BS, DPhil - Publications

Affiliations: 
University of Oxford, Oxford, United Kingdom 
 Medicine University of Cambridge, Cambridge, England, United Kingdom 
Area:
Hypertension, WNK pathway, Renal Physiology, Pre-eclampsia, medical genetics, arterial stiffness, Aldosterone, Conn's Syndrome
Website:
http://emit.medschl.cam.ac.uk/people/investigators/dr-kevin-oshaughnessy/
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43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Louis-Dit-Picard H, Kouranti I, Rafael C, Loisel-Ferreira I, Chavez-Canales M, Abdel Khalek W, Argaiz E, Baron S, Vacle S, Migeon T, Coleman R, Do Cruzeiro M, Hureaux M, Thurairajasingam N, Decramer S, et al. Mutations affecting the conserved acidic WNK1 motif cause inherited hyperkalemic hyperchloremic acidosis. The Journal of Clinical Investigation. PMID 32790646 DOI: 10.1172/Jci94171  0.439
2019 Murthy M, O'Shaughnessy KM. Modified HEK cells simulate DCT cells in their sensitivity and response to changes in extracellular K. Physiological Reports. 7: e14280. PMID 31762176 DOI: 10.14814/phy2.14280  0.518
2019 Sandilands AJ, O'Shaughnessy KM, Yasmin Y. 1-adrenoceptor polymorphisms and blood pressure: 49S variant increases plasma renin but not blood pressure in hypertensive patients. American Journal of Hypertension. PMID 30753253 DOI: 10.1093/Ajh/Hpz019  0.745
2018 Maskari RA, Hardege I, Cleary S, Figg N, Li Y, Siew K, Khir A, Yu Y, Liu P, Wilkinson I, O'Shaughnessy K, Yasmin. Functional characterization of common BCL11B gene desert variants suggests a lymphocyte-mediated association of BCL11B with aortic stiffness. European Journal of Human Genetics : Ejhg. 26: 1648-1657. PMID 30089823 DOI: 10.1038/s41431-018-0226-z  0.677
2018 Yasmin, Maskari RA, McEniery CM, Cleary SE, Li Y, Siew K, Figg NL, Khir AW, Cockcroft JR, Wilkinson IB, O'Shaughnessy KM. The matrix proteins aggrecan and fibulin-1 play a key role in determining aortic stiffness. Scientific Reports. 8: 8550. PMID 29867203 DOI: 10.1038/s41598-018-25851-5  0.709
2017 Hardege I, Long L, Al Maskari R, Figg N, O'Shaughnessy KM. Targeted disruption of the KCNJ5 gene in the female mouse lowers aldosterone levels. Clinical Science (London, England : 1979). PMID 29222092 DOI: 10.1042/Cs20171285  0.775
2017 Ware JS, Wain LV, Channavajjhala SK, Jackson VE, Edwards E, Lu R, Siew K, Jia W, Shrine N, Kinnear S, Jalland M, Henry AP, Clayton J, O'Shaughnessy KM, Tobin MD, et al. Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia. The Journal of Clinical Investigation. 127: 3367-3374. PMID 28783044 DOI: 10.1172/JCI89812  0.735
2016 Murthy M, Kurz T, O'Shaughnessy KM. WNK signalling pathways in blood pressure regulation. Cellular and Molecular Life Sciences : Cmls. PMID 27815594 DOI: 10.1007/s00018-016-2402-z  0.582
2016 Al Maskari R, Yasmin, Cleary S, Figg N, Mehta S, Rassl D, Wilkinson I, O'Shaughnessy KM. A missense TGFB2 variant p.(Arg320Cys) causes a paradoxical and striking increase in aortic TGFB1/2 expression. European Journal of Human Genetics : Ejhg. PMID 27782106 DOI: 10.1038/Ejhg.2016.143  0.733
2016 Murthy M, Kurz T, O'Shaughnessy KM. ROMK expression remains unaltered in a mouse model of familial hyperkalemic hypertension caused by the CUL3Δ403-459 mutation. Physiological Reports. 4. PMID 27378813 DOI: 10.14814/Phy2.12850  0.649
2015 Hardege I, Xu S, Gordon RD, Thompson AJ, Figg N, Stowasser M, Murrell-Lagnado R, O'Shaughnessy KM. Novel insertion mutation in KCNJ5 channel produces constitutive aldosterone release from H295R cells. Molecular Endocrinology (Baltimore, Md.). me20151195. PMID 26340408 DOI: 10.1210/Me.2015-1195  0.738
2015 Schumacher FR, Siew K, Zhang J, Johnson C, Wood N, Cleary SE, Al Maskari RS, Ferryman JT, Hardege I, Yasmin, Figg NL, Enchev R, Knebel A, O'Shaughnessy KM, Kurz T. Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia. Embo Molecular Medicine. 7: 1285-306. PMID 26286618 DOI: 10.15252/emmm.201505444  0.754
2015 Zhang J, Siew K, Macartney T, O'Shaughnessy KM, Alessi DR. Critical role of the SPAK protein kinase CCT domain in controlling blood pressure. Human Molecular Genetics. 24: 4545-58. PMID 25994507 DOI: 10.1093/hmg/ddv185  0.746
2015 Barber J, McKeever TM, McDowell SE, Clayton JA, Ferner RE, Gordon RD, Stowasser M, O'Shaughnessy KM, Hall IP, Glover M. A systematic review and meta-analysis of thiazide-induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation? British Journal of Clinical Pharmacology. 79: 566-77. PMID 25139696 DOI: 10.1111/Bcp.12499  0.521
2014 O'Shaughnessy KM. Gordon Syndrome: a continuing story. Pediatric Nephrology (Berlin, Germany). PMID 25503323 DOI: 10.1007/s00467-014-2956-7  0.3
2014 Murthy M, Xu S, Massimo G, Wolley M, Gordon RD, Stowasser M, O'Shaughnessy KM. Role for germline mutations and a rare coding single nucleotide polymorphism within the KCNJ5 potassium channel in a large cohort of sporadic cases of primary aldosteronism. Hypertension. 63: 783-9. PMID 24420545 DOI: 10.1161/Hypertensionaha.113.02234  0.626
2014 Glover M, Ware JS, Henry A, Wolley M, Walsh R, Wain LV, Xu S, Van't Hoff WG, Tobin MD, Hall IP, Cook S, Gordon RD, Stowasser M, O'Shaughnessy KM. Detection of mutations in KLHL3 and CUL3 in families with FHHt (familial hyperkalaemic hypertension or Gordon's syndrome). Clinical Science (London, England : 1979). 126: 721-6. PMID 24266877 DOI: 10.1042/Cs20130326  0.586
2014 Siew K, de los Heros P, Alessi DR, O'Shaughnessy KM. Erratum: PD.1. Blood pressure maintenance in MO25β has no physiological role in electrolyte homeostasis or systemic blood pressure maintenance in the mouse Journal of Human Hypertension. 28: 342-342. DOI: 10.1038/Jhh.2013.120  0.642
2014 Maskari RA, Cleary S, Li Y, Khir A, Mitchell G, Wilkinson I, O'Shaughnessy K, Yasmin. Genetic variations on chromosome 14 influence BCL11B gene expression levels and aortic stiffness Artery Research. 8: 126-127. DOI: 10.1016/J.Artres.2014.09.070  0.718
2014 Yasmin, McEniery C, Cleary S, Lam B, Kuper H, Endo Y, Kinra S, Chen D, Chandak G, Deanfield J, Lawlor D, Cockcroft J, Wilkinson I, O'Shaughnessy K. Genome wide association scan identifies loci for arterial stiffness in young healthy adults Artery Research. 8: 122. DOI: 10.1016/J.Artres.2014.09.050  0.693
2013 Glover M, O'Shaughnessy KM. Molecular insights from dysregulation of the thiazide-sensitive WNK/SPAK/NCC pathway in the kidney: Gordon syndrome and thiazide-induced hyponatraemia. Clinical and Experimental Pharmacology & Physiology. 40: 876-84. PMID 23683032 DOI: 10.1111/1440-1681.12115  0.631
2013 Siew K, O'Shaughnessy KM. Extrarenal roles of the with-no-lysine[K] kinases (WNKs). Clinical and Experimental Pharmacology & Physiology. 40: 885-94. PMID 23662678 DOI: 10.1111/1440-1681.12108  0.692
2012 Murthy M, Azizan EA, Brown MJ, O'Shaughnessy KM. Characterization of a novel somatic KCNJ5 mutation delI157 in an aldosterone-producing adenoma. Journal of Hypertension. 30: 1827-33. PMID 22743686 DOI: 10.1097/HJH.0b013e328356139f  0.56
2012 Azizan EA, Murthy M, Stowasser M, Gordon R, Kowalski B, Xu S, Brown MJ, O'Shaughnessy KM. Somatic mutations affecting the selectivity filter of KCNJ5 are frequent in 2 large unselected collections of adrenal aldosteronomas. Hypertension. 59: 587-91. PMID 22252394 DOI: 10.1161/Hypertensionaha.111.186239  0.587
2012 Mitchell GF, Verwoert GC, Tarasov KV, Isaacs A, Smith AV, Yasmin, Rietzschel ER, Tanaka T, Liu Y, Parsa A, Najjar SS, O'Shaughnessy KM, Sigurdsson S, De Buyzere ML, Larson MG, et al. Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium. Circulation. Cardiovascular Genetics. 5: 81-90. PMID 22068335 DOI: 10.1161/Circgenetics.111.959817  0.365
2012 Gordon R, Stowasser M, Xu S, Wolley M, Glover M, O'Shaughnessy K. Relevance of plasma aldosterone responsiveness to upright posture, hybrid steroids and histology of Aldosterone-Producing Adenomas (APAs) to the finding of KCNJ5 mutations in some APAs American Journal of Hypertension. 25: 1315-1315. DOI: 10.1038/Ajh.2012.134  0.554
2011 Glover M, Zuber AM, O'Shaughnessy KM. Hypertension, dietary salt intake, and the role of the thiazide-sensitive sodium chloride transporter NCCT. Cardiovascular Therapeutics. 29: 68-76. PMID 21167012 DOI: 10.1111/J.1755-5922.2010.00180.X  0.575
2011 Glover M, O'shaughnessy KM. SPAK and WNK kinases: a new target for blood pressure treatment? Current Opinion in Nephrology and Hypertension. 20: 16-22. PMID 21088576 DOI: 10.1097/Mnh.0B013E32834132Bc  0.597
2010 Glover M, Sweeny C, Davis B, O'Shaughnessy KM. A Single Amino Acid Substitution Makes WNK4 Susceptible to SB 203580 and SB 202190. The Open Medicinal Chemistry Journal. 4: 57-61. PMID 21249167 DOI: 10.2174/1874104501004010057  0.544
2010 Glover M, Mercier Zuber A, Figg N, O'Shaughnessy KM. The activity of the thiazide-sensitive Na(+)-Cl(-) cotransporter is regulated by protein phosphatase PP4. Canadian Journal of Physiology and Pharmacology. 88: 986-95. PMID 20962898 DOI: 10.1139/y10-080  0.57
2010 Rafiqi FH, Zuber AM, Glover M, Richardson C, Fleming S, Jovanović S, Jovanović A, O'Shaughnessy KM, Alessi DR. Role of the WNK-activated SPAK kinase in regulating blood pressure. Embo Molecular Medicine. 2: 63-75. PMID 20091762 DOI: 10.1002/Emmm.200900058  0.681
2009 Glover M, Zuber AM, O'Shaughnessy KM. Renal and brain isoforms of WNK3 have opposite effects on NCCT expression. Journal of the American Society of Nephrology : Jasn. 20: 1314-22. PMID 19470686 DOI: 10.1681/Asn.2008050542  0.577
2008 Murthy M, Cope G, O'Shaughnessy KM. The acidic motif of WNK4 is crucial for its interaction with the K channel ROMK. Biochemical and Biophysical Research Communications. 375: 651-4. PMID 18755144 DOI: 10.1016/j.bbrc.2008.08.076  0.513
2007 Burton TJ, O'Shaughnessy KM, Brown MJ. The epithelial Na+ channel as a determinant of blood pressure Current Hypertension Reviews. 3: 45-49. DOI: 10.2174/157340207779815491  0.444
2006 Golbang AP, Cope G, Hamad A, Murthy M, Liu CH, Cuthbert AW, O'shaughnessy KM. Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved. American Journal of Physiology. Renal Physiology. 291: F1369-76. PMID 16788137 DOI: 10.1152/ajprenal.00468.2005  0.567
2006 Cope G, Murthy M, Golbang AP, Hamad A, Liu CH, Cuthbert AW, O'Shaughnessy KM. WNK1 affects surface expression of the ROMK potassium channel independent of WNK4. Journal of the American Society of Nephrology : Jasn. 17: 1867-74. PMID 16775035 DOI: 10.1681/ASN.2005111224  0.576
2006 Yasmin, O'Shaughnessy KM, McEniery CM, Cockcroft JR, Wilkinson IB. Genetic variation in fibrillin-1 gene is not associated with arterial stiffness in apparently healthy individuals. Journal of Hypertension. 24: 499-502. PMID 16467653 DOI: 10.1097/01.Hjh.0000209986.74477.18  0.402
2005 Golbang AP, Murthy M, Hamad A, Liu CH, Cope G, Van't Hoff W, Cuthbert A, O'Shaughnessy KM. A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 gene. Hypertension. 46: 295-300. PMID 15998707 DOI: 10.1161/01.HYP.0000174326.96918.d6  0.557
2005 Cope G, Golbang A, O'Shaughnessy KM. WNK kinases and the control of blood pressure. Pharmacology & Therapeutics. 106: 221-31. PMID 15866321 DOI: 10.1016/J.Pharmthera.2004.11.010  0.405
2003 Hong G, Lockhart A, Davis B, Rahmoune H, Baker S, Ye L, Thompson P, Shou Y, O'Shaughnessy K, Ronco P, Brown J. PPARgamma activation enhances cell surface ENaCalpha via up-regulation of SGK1 in human collecting duct cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 1966-8. PMID 12923071 DOI: 10.1096/Fj.03-0181Fje  0.354
2001 O'Shaughnessy KM, Fu B, Downing S, Morris NH. Thrombophilic polymorphisms in pre-eclampsia: altered frequency of the functional 98C>T polymorphism of glycoprotein IIIa. Journal of Medical Genetics. 38: 775-7. PMID 11732486 DOI: 10.1136/Jmg.38.11.775  0.36
2001 O'Shaughnessy KM. The genetics of essential hypertension. British Journal of Clinical Pharmacology. 51: 5-11. PMID 11167660 DOI: 10.1046/J.1365-2125.2001.01254.X  0.364
1998 O'Shaughnessy KM, Fu B, Johnson A, Gordon RD. Linkage of Gordon's syndrome to the long arm of chromosome 17 in a region recently linked to familial essential hypertension. Journal of Human Hypertension. 12: 675-8. PMID 9819014 DOI: 10.1038/Sj.Jhh.1000705  0.312
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