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Hao Shao - Publications

Affiliations: 
University of California, San Francisco, San Francisco, CA 
Area:
heat shock protein 70 inhibitor
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35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Ferguson ID, Lin YT, Lam C, Shao H, Tharp KM, Hale M, Kasap C, Mariano MC, Kishishita A, Patiño Escobar B, Mandal K, Steri V, Wang D, Phojanakong P, Tuomivaara ST, et al. Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma. Cell Chemical Biology. PMID 35853457 DOI: 10.1016/j.chembiol.2022.06.010  0.312
2020 Shao H, Oltion K, Wu T, Gestwicki JE. Differential scanning fluorimetry (DSF) screen to identify inhibitors of Hsp60 protein-protein interactions. Organic & Biomolecular Chemistry. PMID 32458889 DOI: 10.1039/D0Ob00928H  0.398
2020 Bengoechea R, Findlay AR, Bhadra AK, Shao H, Stein KC, Pittman SK, Daw J, Gestwicki JE, True HL, Weihl CC. Inhibition of DNAJ-HSP70 interaction improves strength in muscular dystrophy. The Journal of Clinical Investigation. PMID 32427588 DOI: 10.1172/Jci136167  0.364
2020 Wu PK, Hong SK, Chen W, Becker AE, Gundry RL, Lin CW, Shao H, Gestwicki JE, Park JI. Mortalin (HSPA9) facilitates -mutant tumor cell survival by suppressing ANT3-mediated mitochondrial membrane permeability. Science Signaling. 13. PMID 32156782 DOI: 10.1126/Scisignal.Aay1478  0.379
2020 Shao H, Gestwicki JE. Neutral analogs of the heat shock protein 70 (Hsp70) inhibitor, JG-98. Bioorganic & Medicinal Chemistry Letters. 126954. PMID 31952963 DOI: 10.1016/J.Bmcl.2020.126954  0.449
2020 Taylor IR, Assimon VA, Kuo SY, Rinaldi S, Li X, Young ZT, Morra G, Green K, Nguyen D, Shao H, Garneau-Tsodikova S, Colombo G, Gestwicki JE. Tryptophan scanning mutagenesis as a way to mimic the compound-bound state and probe the selectivity of allosteric inhibitors in cells Chemical Science. 11: 1892-1904. DOI: 10.1039/C9Sc04284A  0.335
2019 Eftekharzadeh B, Banduseela VC, Chiesa G, Martínez-Cristóbal P, Rauch JN, Nath SR, Schwarz DMC, Shao H, Marin-Argany M, Di Sanza C, Giorgetti E, Yu Z, Pierattelli R, Felli IC, Brun-Heath I, et al. Author Correction: Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor. Nature Communications. 10: 4605. PMID 31591399 DOI: 10.1038/S41467-019-12578-8  0.332
2019 Wang C, Scott SM, Sun S, Zhao P, Hutt DM, Shao H, Gestwicki JE, Balch WE. Individualized Management of Genetic Diversity in Niemann-Pick C1 through Modulation of the Hsp70 Chaperone System. Human Molecular Genetics. PMID 31509197 DOI: 10.1093/Hmg/Ddz215  0.338
2019 Eftekharzadeh B, Banduseela VC, Chiesa G, Martínez-Cristóbal P, Rauch JN, Nath SR, Schwarz DMC, Shao H, Marin-Argany M, Di Sanza C, Giorgetti E, Yu Z, Pieratelli R, Felli IC, Brun-Heath I, et al. Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor. Nature Communications. 10: 3562. PMID 31395886 DOI: 10.1038/S41467-019-11594-Y  0.355
2019 Taguwa S, Yeh MT, Rainbolt TK, Nayak A, Shao H, Gestwicki JE, Andino R, Frydman J. Zika Virus Dependence on Host Hsp70 Provides a Protective Strategy against Infection and Disease. Cell Reports. 26: 906-920.e3. PMID 30673613 DOI: 10.1016/J.Celrep.2018.12.095  0.323
2018 Rinaldi S, Assimon VA, Young ZT, Morra G, Shao H, Taylor IR, Gestwicki JE, Colombo G. A Local Allosteric Network in Heat Shock Protein 70 (Hsp70) Links Inhibitor Binding to Enzyme Activity and Distal Protein-Protein Interactions. Acs Chemical Biology. PMID 30372610 DOI: 10.1021/Acschembio.8B00712  0.408
2018 Gestwicki JE, Shao H. Inhibitors and chemical probes for molecular chaperone networks. The Journal of Biological Chemistry. PMID 30213856 DOI: 10.1074/Jbc.Tm118.002813  0.396
2018 Polson ES, Kuchler VB, Abbosh C, Ross EM, Mathew RK, Beard HA, da Silva B, Holding AN, Ballereau S, Chuntharpursat-Bon E, Williams J, Griffiths HBS, Shao H, Patel A, Davies AJ, et al. KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice. Science Translational Medicine. 10. PMID 30111643 DOI: 10.1126/Scitranslmed.Aar2718  0.333
2018 Shao H, Li X, Moses MA, Gilbert LA, Kalyanaraman C, Young ZT, Chernova M, Journey SN, Weissman JS, Hann B, Jacobson MP, Neckers LM, Gestwicki JE. Exploration of Benzothiazole-Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70). Journal of Medicinal Chemistry. PMID 29953808 DOI: 10.1021/Acs.Jmedchem.8B00583  0.439
2018 Glazier AA, Hafeez N, Mellacheruvu D, Basrur V, Nesvizhskii AI, Lee LM, Shao H, Tang V, Yob JM, Gestwicki JE, Helms AS, Day SM. HSC70 is a chaperone for wild-type and mutant cardiac myosin binding protein C. Jci Insight. 3. PMID 29875314 DOI: 10.1172/Jci.Insight.99319  0.335
2018 Moses MA, Kim YS, Rivera-Marquez GM, Oshima N, Watson MJ, Beebe K, Wells C, Lee S, Zuehlke AD, Shao H, Bingman WE, Kumar V, Malhotra S, Weigel NL, Gestwicki JE, et al. Targeting the Hsp40/Hsp70 chaperone axis as a novel strategy to treat castration-resistant prostate cancer. Cancer Research. PMID 29764864 DOI: 10.1158/0008-5472.Can-17-3728  0.429
2018 Ran X, Burchfiel ET, Dong B, Rettko NJ, Dunyak BM, Shao H, Thiele DJ, Gestwicki JE. Rational design and screening of peptide-based inhibitors of heat shock factor 1 (HSF1). Bioorganic & Medicinal Chemistry. PMID 29661622 DOI: 10.1016/J.Bmc.2018.04.018  0.398
2018 Taylor IR, Dunyak BM, Komiyama T, Shao H, Ran X, Assimon VA, Kalyanaraman C, Rauch JN, Jacobson MP, Zuiderweg ERP, Gestwicki JE. High Throughput Screen for Inhibitors of Protein-Protein Interactions in a Reconstituted Heat Shock Protein 70 (Hsp70) Complex. The Journal of Biological Chemistry. PMID 29414793 DOI: 10.1074/Jbc.Ra117.001575  0.422
2018 Ferguson I, Lam C, Mariano MC, Wang D, Phojanakong P, Toumivaara S, Shao H, Hann BC, Gestwicki J, Wiita AP. Novel Allosteric Inhibitors of Heat Shock Protein 70 As Agents to Probe Protein Homeostasis and Overcome Proteasome Inhibitor Resistance in Multiple Myeloma Blood. 132: 3212-3212. DOI: 10.1182/Blood-2018-99-117401  0.421
2018 Moses MA, Rivera-Marquez G, Taylor I, Shao H, Gestwicki J, Trepel J, Neckers L. Abstract 2901: Identifying synthetic lethal interactions in castration-resistant prostate cancer using HSP40 and HSP70 inhibitors Cancer Research. 78: 2901-2901. DOI: 10.1158/1538-7445.Am2018-2901  0.427
2017 Cesa LC, Shao H, Srinivasan SR, Tse E, Jain C, Zuiderweg ERP, Southworth DR, Mapp AK, Gestwicki JE. X-Linked Inhibitor of Apoptosis Protein (XIAP) is a Client of Heat Shock Protein 70 (Hsp70) and a Biomarker of its Inhibition. The Journal of Biological Chemistry. PMID 29255093 DOI: 10.1074/Jbc.Ra117.000634  0.455
2017 Srinivasan SR, Cesa LC, Li X, Julien O, Zhuang M, Shao H, Chung J, Maillard I, Wells JA, Duckett C, Gestwicki JE. Heat Shock Protein 70 (Hsp70) Suppresses RIP1-dependent Apoptotic and Necroptotic Cascades. Molecular Cancer Research : McR. PMID 28970360 DOI: 10.1158/1541-7786.Mcr-17-0408  0.447
2016 Gabai VL, Yaglom J, Wang Y, Meng L, Shao H, Kim G, Colvin T, Gestwicki J, Sherman MY. Anti-cancer effects of targeting Hsp70 in tumor stromal cells. Cancer Research. PMID 27503927 DOI: 10.1158/0008-5472.Can-16-0800  0.365
2016 Ouimet CM, Shao H, Rauch JN, Dawod M, Nordhues BA, Dickey CA, Gestwicki JE, Kennedy RT. Protein Cross-linking Capillary Electrophoresis (PXCE) for Protein-Protein Interaction Analysis. Analytical Chemistry. PMID 27434096 DOI: 10.1021/Acs.Analchem.6B02126  0.344
2016 Li X, Shao H, Taylor IR, Gestwicki JE. Targeting Allosteric Control Mechanisms in Heat Shock Protein 70 (Hsp70). Current Topics in Medicinal Chemistry. PMID 27072701 DOI: 10.2174/1568026616666160413140911  0.421
2016 Khachatoorian R, Riahi R, Ganapathy E, Shao H, Wheatley NM, Sundberg C, Jung CL, Ruchala P, Dasgupta A, Arumugaswami V, Gestwicki JE, French SW. Allosteric heat shock protein 70 inhibitors block hepatitis C virus assembly. International Journal of Antimicrobial Agents. PMID 27013001 DOI: 10.1016/J.Ijantimicag.2016.01.012  0.396
2014 Lam F, Abbas AY, Shao H, Teo T, Adams J, Li P, Bradshaw TD, Fischer PM, Walsby E, Pepper C, Chen Y, Ding J, Wang S. Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73. Oncotarget. 5: 7691-704. PMID 25277198 DOI: 10.18632/Oncotarget.2296  0.372
2014 Walsby E, Pratt G, Shao H, Abbas AY, Fischer PM, Bradshaw TD, Brennan P, Fegan C, Wang S, Pepper C. A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine. Oncotarget. 5: 375-85. PMID 24495868 DOI: 10.18632/Oncotarget.1568  0.357
2013 Shao H, Shi S, Foley DW, Lam F, Abbas AY, Liu X, Huang S, Jiang X, Baharin N, Fischer PM, Wang S. Synthesis, structure-activity relationship and biological evaluation of 2,4,5-trisubstituted pyrimidine CDK inhibitors as potential anti-tumour agents. European Journal of Medicinal Chemistry. 70: 447-55. PMID 24185375 DOI: 10.1016/J.Ejmech.2013.08.052  0.377
2013 Shao H, Shi S, Huang S, Hole AJ, Abbas AY, Baumli S, Liu X, Lam F, Foley DW, Fischer PM, Noble M, Endicott JA, Pepper C, Wang S. Substituted 4-(thiazol-5-yl)-2-(phenylamino)pyrimidines are highly active CDK9 inhibitors: synthesis, X-ray crystal structures, structure-activity relationship, and anticancer activities. Journal of Medicinal Chemistry. 56: 640-59. PMID 23301767 DOI: 10.1021/Jm301475F  0.387
2013 Hole AJ, Baumli S, Shao H, Shi S, Huang S, Pepper C, Fischer PM, Wang S, Endicott JA, Noble ME. Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity. Journal of Medicinal Chemistry. 56: 660-70. PMID 23252711 DOI: 10.1021/Jm301495V  0.366
2013 Shao H, Shi S, Huang S, Hole A, Abbas AY, Baumli S, Liu X, Lam F, Foley DW, Fischer PM, Noble M, Endicott JA, Pepper C, Wang S. Substituted 4-(Thiazol-5-Yl)-2-(Phenylamino)Pyrimidines are Highly Active Cdk9 Inhibitors: Synthesis, X-Ray Crystal Structure, Sar and Anti-Cancer Activities. Journal of Medicinal Chemistry. 56: 640. DOI: 10.2210/Pdb4Bcg/Pdb  0.308
2013 Shao H, Foley D, Abbas AY, Hole AJ, Huang S, Shi S, Baumli S, Bradshaw TD, Noble M, Endicott JA, Pepper C, Wang S, Fischer PM. Abstract 697: Synthesis and biological evaluation of 2,4,5-substituted pyrimidines as highly selective CDK9 inhibitors for cancer treatment. Cancer Research. 73: 697-697. DOI: 10.1158/1538-7445.Am2013-697  0.399
2012 Lukasik PM, Elabar S, Lam F, Shao H, Liu X, Abbas AY, Wang S. Synthesis and biological evaluation of imidazo[4,5-b]pyridine and 4-heteroaryl-pyrimidine derivatives as anti-cancer agents. European Journal of Medicinal Chemistry. 57: 311-22. PMID 23085105 DOI: 10.1016/J.Ejmech.2012.09.034  0.32
2012 Shao H, Abbas AY, Shi S, Foley D, Huang S, Bradshaw TD, Pepper C, Endicott JA, Wang S, Fischer PM. 274 Synthesis and in Vitro Evaluation of Selective CDK9 Inhibitors European Journal of Cancer. 48: 84. DOI: 10.1016/S0959-8049(12)72072-5  0.32
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