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John B. Little, M.D. - Publications

Affiliations: 
Harvard University, Cambridge, MA, United States 
Website:
http://www.hsph.harvard.edu/john-little/
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328 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Kuser-Abali G, Gong L, Yan J, Liu Q, Zeng W, Williamson A, Lim CB, Molloy ME, Little JB, Huang L, Yuan ZM. An EZH2-mediated epigenetic mechanism behind p53-dependent tissue sensitivity to DNA damage. Proceedings of the National Academy of Sciences of the United States of America. PMID 29540569 DOI: 10.1073/Pnas.1719532115  0.334
2018 Gong L, Pan X, Lim CB, de Polo A, Little JB, Yuan ZM. A functional interplay between Δ133p53 and ΔNp63 in promoting glycolytic metabolism to fuel cancer cell proliferation. Oncogene. PMID 29371679 DOI: 10.1038/S41388-017-0117-8  0.313
2017 Nagasawa H, Lin YF, Kato TA, Brogan JR, Shih HY, Kurimasa A, Bedford JS, Chen BP, Little JB. Coordination of the Ser2056 and Thr2609 Clusters of DNA-PKcs in Regulating Gamma Rays and Extremely Low Fluencies of Alpha-Particle Irradiation to G0/G1 Phase Cells. Radiation Research. PMID 28118114 DOI: 10.1667/Rr14679.1  0.389
2014 Lin YF, Nagasawa H, Little JB, Kato TA, Shih HY, Xie XJ, Wilson PF, Brogan JR, Kurimasa A, Chen DJ, Bedford JS, Chen BP. Differential radiosensitivity phenotypes of DNA-PKcs mutations affecting NHEJ and HRR systems following irradiation with gamma-rays or very low fluences of alpha particles. Plos One. 9: e93579. PMID 24714417 DOI: 10.1371/Journal.Pone.0093579  0.405
2014 Lall R, Ganapathy S, Yang M, Xiao S, Xu T, Su H, Shadfan M, Asara JM, Ha CS, Ben-Sahra I, Manning BD, Little JB, Yuan ZM. Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response. Cell Death and Differentiation. 21: 836-44. PMID 24583639 DOI: 10.1038/Cdd.2014.24  0.343
2014 Ganapathy S, Xiao S, Yang M, Qi M, Choi DE, Ha CS, Little JB, Yuan ZM. A low-dose arsenic-induced p53 protein-mediated metabolic mechanism of radiotherapy protection. The Journal of Biological Chemistry. 289: 5340-7. PMID 24391088 DOI: 10.1074/Jbc.M113.531020  0.354
2012 Paquette B, Wagner R, Little J. In vitro reversion of transformed phenotype in mouse C3H/10T1/2 cells. International Journal of Oncology. 8: 727-34. PMID 21544420 DOI: 10.3892/Ijo.8.4.727  0.361
2011 Williams JR, Zhang Y, Zhou H, Gridley DS, Koch CJ, Slater JM, Dicello JF, Little JB. Sequentially-induced responses define tumour cell radiosensitivity. International Journal of Radiation Biology. 87: 628-43. PMID 21501033 DOI: 10.3109/09553002.2011.568573  0.357
2011 Autsavapromporn N, de Toledo SM, Little JB, Jay-Gerin JP, Harris AL, Azzam EI. The role of gap junction communication and oxidative stress in the propagation of toxic effects among high-dose α-particle-irradiated human cells. Radiation Research. 175: 347-57. PMID 21388278 DOI: 10.1667/Rr2372.1  0.371
2011 Nagasawa H, Little JB, Lin YF, So S, Kurimasa A, Peng Y, Brogan JR, Chen DJ, Bedford JS, Chen BP. Differential role of DNA-PKcs phosphorylations and kinase activity in radiosensitivity and chromosomal instability. Radiation Research. 175: 83-9. PMID 21175350 DOI: 10.1667/Rr2092.1  0.365
2011 Little JB, Williams JR. Effects of Ionizing Radiation on Mammalian Cells Comprehensive Physiology. 127-155. DOI: 10.1002/Cphy.Cp090108  0.409
2010 Williams JR, Zhang Y, Zhou H, Gridley DS, Koch CJ, Dicello JF, Slater JM, Little JB. Tumor response to radiotherapy is dependent on genotype-associated mechanisms in vitro and in vivo. Radiation Oncology (London, England). 5: 71. PMID 20704711 DOI: 10.1186/1748-717X-5-71  0.314
2010 Nagasawa H, Brogan JR, Peng Y, Little JB, Bedford JS. Some unsolved problems and unresolved issues in radiation cytogenetics: a review and new data on roles of homologous recombination and non-homologous end joining. Mutation Research. 701: 12-22. PMID 20298803 DOI: 10.1016/J.Mrgentox.2010.03.003  0.388
2010 Wilson PF, Nagasawa H, Fitzek MM, Little JB, Bedford JS. G2-phase chromosomal radiosensitivity of primary fibroblasts from hereditary retinoblastoma family members and some apparently normal controls Radiation Research. 173: 62-70. PMID 20041760 DOI: 10.1667/Rr1943.1  0.39
2010 Little JB, Chang RS. Radiation Resistance in Lipovirus-Altered Human Cells. Science (New York, N.Y.). 148: 1746-7. PMID 17819436 DOI: 10.1126/Science.148.3678.1746  0.418
2009 Kato TA, Wilson PF, Nagasaw H, Peng Y, Weil MM, Little JB, Bedford JS. Variations in radiosensitivity among individuals: A potential impact on risk assessment? Health Physics. 97: 470-480. PMID 19820456 DOI: 10.1097/Hp.0B013E3181B08Eee  0.396
2009 Tsai KK, Stuart J, Chuang YY, Little JB, Yuan ZM. Low-dose radiation-induced senescent stromal fibroblasts render nearby breast cancer cells radioresistant. Radiation Research. 172: 306-13. PMID 19708779 DOI: 10.1667/Rr1764.1  0.404
2008 Williams JR, Zhang Y, Zhou H, Gridley DS, Koch CJ, Slater JM, Little JB. Overview of Radiosensitivity of Human Tumor Cells to Low-Dose-Rate Irradiation International Journal of Radiation Oncology Biology Physics. 72: 909-917. PMID 19014780 DOI: 10.1016/J.Ijrobp.2008.06.1928  0.388
2008 Wilson PF, Nagasawa H, Warner CL, Fitzek MM, Little JB, Bedford JS. Radiation sensitivity of primary fibroblasts from hereditary retinoblastoma family members and some apparently normal controls: colony formation ability during continuous low-dose-rate gamma irradiation. Radiation Research. 169: 483-94. PMID 18439048 DOI: 10.1667/Rr1333.1  0.391
2008 Williams JR, Zhang Y, Zhou H, Gridley DS, Koch CJ, Russell J, Slater JS, Little JB. A quantitative overview of radiosensitivity of human tumor cells across histological type and TP53 status International Journal of Radiation Biology. 84: 253-264. PMID 18386191 DOI: 10.1080/09553000801953342  0.322
2008 Williams JR, Zhang Y, Zhou H, Russell J, Gridley DS, Koch CJ, Little JB. Genotype-dependent radiosensitivity: Clonogenic survival, apoptosis and cell-cycle redistribution International Journal of Radiation Biology. 84: 151-164. PMID 18246483 DOI: 10.1080/09553000701797021  0.365
2008 Nagasawa H, Wilson PF, Chen DJ, Thompson LH, Bedford JS, Little JB. Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination Dna Repair. 7: 515-522. PMID 18182331 DOI: 10.1016/J.Dnarep.2007.11.014  0.397
2008 Venkatachalam P, De Toledo SM, Pandey BN, Tephly LA, Carter AB, Little JB, Spitz DR, Azzam EI. Regulation of normal cell cycle progression by flavin-containing oxidases Oncogene. 27: 20-31. PMID 17637756 DOI: 10.1038/Sj.Onc.1210634  0.346
2007 Little JB. Nontargeted effects of ionizing radiation: implications for low-dose exposures Radiatsionnaia Biologiia, Radioecologiia / RossiǐSkaia Akademiia Nauk. 47: 262-272. PMID 17867493  0.342
2007 Williams JR, Zhang Y, Russell J, Koch C, Little JB. Human tumor cells segregate into radiosensitivity groups that associate with ATM and TP53 status Acta Oncologica. 46: 628-638. PMID 17562439 DOI: 10.1080/02841860601080407  0.358
2007 Kato TA, Wilson PF, Nagasawa H, Fitzek MM, Weil MM, Little JB, Bedford JS. A defect in DNA double strand break processing in cells from unaffected parents of retinoblastoma patients and other apparently normal humans Dna Repair. 6: 818-829. PMID 17339135 DOI: 10.1016/J.Dnarep.2007.01.008  0.391
2006 Urashima T, Nagasawa H, Wang K, Adelstein SJ, Little JB, Kassis AI. Induction of apoptosis in human tumor cells after exposure to Auger electrons: comparison with γ-ray exposure Nuclear Medicine and Biology. 33: 1055-1063. PMID 17127180 DOI: 10.1016/J.Nucmedbio.2006.09.002  0.426
2006 Little JB. Lauriston S. Taylor lecture: Nontargeted effects of radiation: Implications for low-dose exposures Health Physics. 91: 416-426. PMID 17033451 DOI: 10.1097/01.Hp.0000232847.23192.3E  0.453
2006 Kato TA, Nagasawa H, Weil MM, Little JB, Bedford JS. Levels of γ-H2AX foci after low-dose-rate irradiation reveal a DNA DSB rejoining defect in cells from human ATM heterozygotes in two AT families and in another apparently normal individual Radiation Research. 166: 443-453. PMID 16953663 DOI: 10.1667/Rr3604.1  0.304
2006 Little JB. Cellular radiation effects and the bystander response Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 597: 113-118. PMID 16413041 DOI: 10.1016/J.Mrfmmm.2005.12.001  0.376
2005 Tsai KK, Chuang EY, Little JB, Yuan ZM. Cellular mechanisms for low-dose ionizing radiation-induced perturbation of the breast tissue microenvironment. Cancer Research. 65: 6734-44. PMID 16061655 DOI: 10.1158/0008-5472.Can-05-0703  0.398
2005 Nagasawa H, Peng Y, Wilson PF, Lio YC, Chen DJ, Bedford JS, Little JB. Role of homologous recombination in the alpha-particle-induced bystander effect for sister chromatid exchanges and chromosomal aberrations. Radiation Research. 164: 141-7. PMID 16038585 DOI: 10.1667/Rr3420  0.402
2005 Little JB, Azzam EI, De Toledo SM, Nagasawa H. Characteristics and mechanisms of the bystander response in monolayer cell cultures exposed to very low fluences of alpha particles Radiation Physics and Chemistry. 72: 307-313. DOI: 10.1016/J.Radphyschem.2003.12.062  0.437
2004 Azzam EI, Little JB. The radiation-induced bystander effect: evidence and significance. Human & Experimental Toxicology. 23: 61-5. PMID 15070061 DOI: 10.1191/0960327104Ht418Oa  0.401
2004 Danaee H, Nelson HH, Liber H, Little JB, Kelsey KT. Low dose exposure to sodium arsenite synergistically interacts with UV radiation to induce mutations and alter DNA repair in human cells. Mutagenesis. 19: 143-8. PMID 14981161 DOI: 10.1093/Mutage/Geh010  0.423
2004 Azzam EI, de Toledo SM, Little JB. Stress signaling from irradiated to non-irradiated cells. Current Cancer Drug Targets. 4: 53-64. PMID 14965267 DOI: 10.2174/1568009043481641  0.429
2003 Glover D, Little JB, Lavin MF, Gueven N. Low dose ionizing radiation-induced activation of connexin 43 expression. International Journal of Radiation Biology. 79: 955-64. PMID 14713573 DOI: 10.1080/09553000310001632895  0.383
2003 Mamon HJ, Dahlberg W, Azzam EI, Nagasawa H, Muto MG, Little JB. Differing effects of breast cancer 1, early onset (BRCA1) and ataxia-telangiectasia mutated (ATM) mutations on cellular responses to ionizing radiation. International Journal of Radiation Biology. 79: 817-29. PMID 14630541 DOI: 10.1080/09553000310001610952  0.33
2003 Brenner DJ, Doll R, Goodhead DT, Hall EJ, Land CE, Little JB, Lubin JH, Preston DL, Preston RJ, Puskin JS, Ron E, Sachs RK, Samet JM, Setlow RB, Zaider M. Cancer risks attributable to low doses of ionizing radiation: assessing what we really know. Proceedings of the National Academy of Sciences of the United States of America. 100: 13761-6. PMID 14610281 DOI: 10.1073/Pnas.2235592100  0.332
2003 Azzam EI, de Toledo SM, Little JB. Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect. Oncogene. 22: 7050-7. PMID 14557810 DOI: 10.1038/Sj.Onc.1206961  0.371
2003 Little JB. Genomic instability and bystander effects: a historical perspective. Oncogene. 22: 6978-87. PMID 14557801 DOI: 10.1038/Sj.Onc.1206988  0.397
2003 Little JB. Genomic instability and radiation. Journal of Radiological Protection : Official Journal of the Society For Radiological Protection. 23: 173-81. PMID 12875549 DOI: 10.1088/0952-4746/23/2/304  0.4
2003 Nagasawa H, Huo L, Little JB. Increased bystander mutagenic effect in DNA double-strand break repair-deficient mammalian cells. International Journal of Radiation Biology. 79: 35-41. PMID 12556329 DOI: 10.1080/0955300021000019230  0.397
2003 Little JB, Nagasawa H, Li GC, Chen DJ. Involvement of the nonhomologous end joining DNA repair pathway in the bystander effect for chromosomal aberrations. Radiation Research. 159: 262-7. PMID 12537532 DOI: 10.1667/0033-7587(2003)159[0262:Iotnej]2.0.Co;2  0.431
2002 Azzam EI, Nagasawa H, Yu Y, Li CY, Little JB. Cell cycle deregulation and xeroderma pigmentosum group C cell transformation. The Journal of Investigative Dermatology. 119: 1350-4. PMID 12485438 DOI: 10.1046/J.1523-1747.2002.19628.X  0.387
2002 Schäfer J, Bachtler J, Engling A, Little JB, Weber KJ, Wenz F. Suppression of apoptosis and clonogenic survival in irradiated human lymphoblasts with different TP53 status. Radiation Research. 158: 699-706. PMID 12452772 DOI: 10.1667/0033-7587(2002)158[0699:Soaacs]2.0.Co;2  0.423
2002 Nagasawa H, Little JB. Bystander effect for chromosomal aberrations induced in wild-type and repair deficient CHO cells by low fluences of alpha particles. Mutation Research. 508: 121-9. PMID 12379467 DOI: 10.1016/S0027-5107(02)00193-8  0.431
2002 Little JB, Azzam EI, de Toledo SM, Nagasawa H. Bystander effects: intercellular transmission of radiation damage signals. Radiation Protection Dosimetry. 99: 159-62. PMID 12194273 DOI: 10.1093/Oxfordjournals.Rpd.A006751  0.407
2002 Little JB, Nagasawa H, Dahlberg WK, Zdzienicka MZ, Burma S, Chen DJ. Differing responses of Nijmegen breakage syndrome and ataxia telangiectasia cells to ionizing radiation. Radiation Research. 158: 319-26. PMID 12175309 DOI: 10.1667/0033-7587(2002)158[0319:Dronbs]2.0.Co;2  0.443
2002 Fitzek MM, Dahlberg WK, Nagasawa H, Mukai S, Munzenrider JE, Little JB. Unexpected sensitivity to radiation of fibroblasts from unaffected parents of children with hereditary retinoblastoma. International Journal of Cancer. Journal International Du Cancer. 99: 764-8. PMID 12115515 DOI: 10.1002/Ijc.10401  0.307
2002 Kurimasa A, Burma S, Henrie M, Ouyang H, Osaki M, Ito H, Nagasawa H, Little JB, Oshimura M, Li GC, Chen DJ. Disruption of NBS1 gene leads to early embryonic lethality in homozygous null mice and induces specific cancer in heterozygous mice Lawrence Berkeley National Laboratory. DOI: 10.2172/943450  0.322
2001 Romney CA, Paulauskis JD, Nagasawa H, Little JB. Multiple manifestations of X-ray-induced genomic instability in Chinese hamster ovary (CHO) cells. Molecular Carcinogenesis. 32: 118-27. PMID 11746824 DOI: 10.1002/Mc.1071  0.397
2001 Huo L, Nagasawa H, Little JB. HPRT mutants induced in bystander cells by very low fluences of alpha particles result primarily from point mutations. Radiation Research. 156: 521-5. PMID 11604065 DOI: 10.1667/0033-7587(2001)156[0521:Hmiibc]2.0.Co;2  0.383
2001 Romney CA, Paulauskis JD, Little JB. X-ray induction of microsatellite instability at autosomal loci in human lymphoblastoid WTK1 cells. Mutation Research. 478: 97-106. PMID 11406174 DOI: 10.1016/S0027-5107(01)00126-9  0.368
2001 Kennedy AR, Little JB. Investigation of the mechanism for enhancement of radiation transformation in vitro by 12-O-tetradecanoylphorbol-13-acetate. Carcinogenesis. 1: 1039-47. PMID 11272108 DOI: 10.1093/Carcin/1.12.1039  0.418
2001 Brenner DJ, Little JB, Sachs RK. The bystander effect in radiation oncogenesis: II. A quantitative model Radiation Research. 155: 402-408. PMID 11182790 DOI: 10.1667/0033-7587(2001)155[0402:Tbeiro]2.0.Co;2  0.368
2001 Azzam EI, de Toledo SM, Little JB. Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha -particle irradiated to nonirradiated cells. Proceedings of the National Academy of Sciences of the United States of America. 98: 473-8. PMID 11149936 DOI: 10.1073/Pnas.011417098  0.418
2001 Syljuåsen RG, Krolewski B, Little JB. Molecular events in radiation transformation. Radiation Research. 155: 215-221. PMID 11121237 DOI: 10.1667/0033-7587(2001)155[0215:Meirt]2.0.Co;2  0.389
2000 de Toledo SM, Azzam EI, Dahlberg WK, Gooding TB, Little JB. ATM complexes with HDM2 and promotes its rapid phosphorylation in a p53-independent manner in normal and tumor human cells exposed to ionizing radiation. Oncogene. 19: 6185-93. PMID 11175332 DOI: 10.1038/Sj.Onc.1204020  0.389
2000 Honma M, Momose M, Tanabe H, Sakamoto H, Yu Y, Little JB, Sofuni T, Hayashi M. Requirement of wild-type p53 protein for maintenance of chromosomal integrity. Molecular Carcinogenesis. 28: 203-14. PMID 10972990 DOI: 10.1002/1098-2744(200008)28:4<203::Aid-Mc3>3.0.Co;2-1  0.325
2000 Kano Y, Nohno T, Takahashi R, Hiragami F, Kawamura K, Strebhardt K, Namba M, Sugiyama T, Little JB. Morphological alteration of X-ray induced partially transformed human cells by transfection with a small c-myc DNA sequence. Biochemical and Biophysical Research Communications. 272: 887-94. PMID 10860847 DOI: 10.1006/Bbrc.2000.2858  0.394
2000 Moon Y, Todoroki T, Ohno T, Fukao K, Little JB. Enhanced radiation killing by 5-fluorouracil of biliary tract cancer cell lines. International Journal of Oncology. 16: 987-94. PMID 10762635 DOI: 10.3892/Ijo.16.5.987  0.425
2000 Little JB. Radiation carcinogenesis. Carcinogenesis. 21: 397-404. PMID 10688860  0.315
2000 Krolewski B, Little JB. Overexpression of p21 protein in radiation-transformed mouse 10T(1/2) cell clones. Molecular Carcinogenesis. 27: 141-8. PMID 10657906 DOI: 10.1002/(Sici)1098-2744(200002)27:2<141::Aid-Mc9>3.0.Co;2-W  0.335
1999 Nagasawa H, Little JB. Unexpected sensitivity to the induction of mutations by very low doses of alpha-particle radiation: evidence for a bystander effect. Radiation Research. 152: 552-7. PMID 10521933 DOI: 10.2307/3580153  0.33
1999 Mariotta M, Perewusnyk G, Koechli OR, Little JB, von Knebel Doeberitz M, Mirimanoff RO, Rutz HP. Dexamethasone-induced enhancement of resistance to ionizing radiation and chemotherapeutic agents in human tumor cells. Strahlentherapie Und Onkologie : Organ Der Deutschen RöNtgengesellschaft ... [Et Al]. 175: 392-6. PMID 10481771 DOI: 10.1007/S000660050027  0.363
1999 Kano Y, Motoda H, Hiragami F, Matsui K, Little JB, Namba M. SV40LT highly mutates and immortalizes two fibroblast strains from patients with Wilms' tumor. Cell Structure and Function. 24: 35-41. PMID 10355877 DOI: 10.1247/Csf.24.35  0.334
1999 Little JB. Induction of genetic instability by ionizing radiation. Comptes Rendus De L'AcadéMie Des Sciences. SéRie Iii, Sciences De La Vie. 322: 127-34. PMID 10196663 DOI: 10.1016/S0764-4469(99)80034-1  0.412
1999 Moon Y, Todoroki T, Ohno T, Fukao K, Little JB. Killing effects of 5-fluorouracil on human biliary tract cancer cell lines. International Journal of Oncology. 14: 253-7. PMID 9917499 DOI: 10.3892/Ijo.14.2.253  0.371
1998 Little JB. Radiation-induced genomic instability. International Journal of Radiation Biology. 74: 663-71. PMID 9881710 DOI: 10.1080/095530098140925  0.43
1998 Azzam EI, de Toledo SM, Gooding T, Little JB. Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles. Radiation Research. 150: 497-504. PMID 9806590 DOI: 10.2307/3579865  0.371
1998 Li GC, Ouyang H, Li X, Nagasawa H, Little JB, Chen DJ, Ling CC, Fuks Z, Cordon-Cardo C. Ku70: a candidate tumor suppressor gene for murine T cell lymphoma. Molecular Cell. 2: 1-8. PMID 9702186 DOI: 10.1016/S1097-2765(00)80108-2  0.32
1998 Pykett MJ, Azzam E, Dahlberg W, Little JB. Differential p53, p21, mdm2 and Rb regulation in glioma cell lines that overexpress wild-type p53. International Journal of Oncology. 13: 213-6. PMID 9664113 DOI: 10.3892/Ijo.13.2.213  0.31
1998 Ray FA, Waltman MJ, Lehman JM, Little JB, Nickoloff JA, Kraemer PM. Identification of SV40 T-antigen mutants that alter T-antigen-induced chromosome damage in human fibroblasts. Cytometry. 31: 242-50. PMID 9551599 DOI: 10.1002/(Sici)1097-0320(19980401)31:4<242::Aid-Cyto3>3.0.Co;2-L  0.316
1998 Wenz F, Azzam EI, Little JB. The response of proliferating cell nuclear antigen to ionizing radiation in human lymphoblastoid cell lines is dependent on p53. Radiation Research. 149: 32-40. PMID 9421152 DOI: 10.2307/3579679  0.39
1998 Ray F, Waltman M, Lehman J, Little J, Nickoloff J, Kraemer P. Identification of SV40 T-antigen mutants that alter T-antigen-induced chromosome damage in human fibroblasts. Cytometry 31:242-250, 1998. Cytometry. 32: 260-260. DOI: 10.1002/(Sici)1097-0320(19980701)32:3<260::Aid-Cyto13>3.0.Co;2-L  0.317
1997 Bill CA, Yu Y, Miselis NR, Little JB, Nickoloff JA. A role for p53 in DNA end rejoining by human cell extracts. Mutation Research. 385: 21-9. PMID 9372845 DOI: 10.1016/S0921-8777(97)00040-2  0.375
1997 Little JB, Nagasawa H, Pfenning T, Vetrovs H. Radiation-induced genomic instability: delayed mutagenic and cytogenetic effects of X rays and alpha particles. Radiation Research. 148: 299-307. PMID 9339945 DOI: 10.2307/3579514  0.364
1997 Caron RM, Nagasawa H, Yu Y, Pfenning T, Vetrovs H, Little JB. Evidence for a role for genomic instability in radiation-induced mutagenesis. Radiation Oncology Investigations. 5: 119-23. PMID 9303068 DOI: 10.1002/(Sici)1520-6823(1997)5:3<119::Aid-Roi7>3.0.Co;2-0  0.309
1997 Wenz F, Yu Y, Nagasawa H, Imrich AC, Keng P, Little JB. Lack of uncoupling of S phase and mitosis after irradiation in p53- human lymphoblast cell lines. Radiation Research. 148: 129-34. PMID 9254731 DOI: 10.2307/3579569  0.397
1997 Yu Y, Li CY, Little JB. Abrogation of p53 function by HPV16 E6 gene delays apoptosis and enhances mutagenesis but does not alter radiosensitivity in TK6 human lymphoblast cells. Oncogene. 14: 1661-7. PMID 9135067 DOI: 10.1038/Sj.Onc.1201026  0.357
1997 Moon Y, Dahlberg WK, Yu Y, Ohno T, Todoroki T, Little JB. Radiosensitivity of human biliary tract cancer cell lines in vitro International Journal of Oncology. 10: 545-551. DOI: 10.3892/Ijo.10.3.545  0.368
1997 Pykett MJ, Azzam E, Little JB. Differential regulation of cdk2 and cyclin D1 in irradiated human glioma cells International Journal of Oncology. 10: 93-99. DOI: 10.3892/Ijo.10.1.93  0.387
1997 Little JB. O X.1 Radiation-induced genomic instability: Delayed mutagenic and cytogenetic effects Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 379: S69. DOI: 10.1016/S0027-5107(97)82834-5  0.31
1996 Suardet L, Li C, Little JB. Radio-induced modulation of transforming growth factor beta1 sensitivity in a p53 wild-type human colorectal-cancer cell line. International Journal of Cancer. Journal International Du Cancer. 68: 126-31. PMID 8895552 DOI: 10.1002/(Sici)1097-0215(19960927)68:1<126::Aid-Ijc22>3.0.Co;2-8  0.336
1996 Gery B, Coppey J, Little JB. Modulation of clonogenicity, growth, and radiosensitivity of three human epidermoid tumor cell lines by a fibroblastic environment. International Journal of Radiation Oncology, Biology, Physics. 34: 1061-71. PMID 8600089 DOI: 10.1016/0360-3016(95)02175-2  0.371
1995 Rutz HP, Little JB. Exogenous lactate interferes with cell-cycle control in Balb/3T3 mouse fibroblasts. International Journal of Radiation Oncology, Biology, Physics. 31: 525-8. PMID 7852115 DOI: 10.1016/0360-3016(94)00362-O  0.404
1995 Little JB, Nagasawa H, Keng PC, Yu Y, Li CY. Absence of radiation-induced G1 arrest in two closely related human lymphoblast cell lines that differ in p53 status. The Journal of Biological Chemistry. 270: 11033-6. PMID 7744731 DOI: 10.1074/Jbc.270.19.11033  0.397
1995 Honma M, Little JB. Recombinagenic activity of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate in human lymphoblastoid cells. Carcinogenesis. 16: 1717-22. PMID 7634395 DOI: 10.1093/Carcin/16.8.1717  0.344
1995 Kinashi Y, Nagasawa H, Little JB. Molecular structural analysis of 417 HPRT mutations induced by restriction endonucleases in Chinese hamster ovary (CHO) cells. Mutation Research. 326: 83-92. PMID 7528888 DOI: 10.1016/0027-5107(94)00151-T  0.322
1995 Metting NF, Little JB. Transient Failure to Dephosphorylate the cdc2-Cyclin B1 Complex Accompanies Radiation-Induced G 2 -Phase Arrest in HeLa Cells Radiation Research. 143: 286. DOI: 10.2307/3579215  0.323
1995 Kinashi Y, Okayasu R, Iliakis GE, Nagasawa H, Little JB. Induction of DNA Double-Strand Breaks by Restriction Enzymes in X-Ray-Sensitive Mutant Chinese Hamster Ovary Cells Measured by Pulsed-Field Gel Electrophoresis Radiation Research. 141: 153. DOI: 10.2307/3579042  0.341
1995 Li C, Nagasawa H, Little JB. Role of tumor suppressor genes in determining radiation-induced G1 arrest and transformation in human cells Radiation Oncology Investigations. 3: 268-271. DOI: 10.1002/Roi.2970030604  0.369
1994 Nagasawa H, Keng P, Harley R, Dahlberg W, Little JB. Relationship between gamma-ray-induced G2/M delay and cellular radiosensitivity. International Journal of Radiation Biology. 66: 373-9. PMID 7930839 DOI: 10.1080/09553009414551311  0.395
1994 Krolewski B, Little JB. Search for oncogene mutations in X-ray-transformed mouse 10T1/2 cells by denaturing gradient gel electrophoresis blotting. International Journal of Radiation Biology. 65: 147-56. PMID 7907112 DOI: 10.1080/09553009414550181  0.326
1994 Little JB. Changing Views of Cellular Radiosensitivity Radiation Research. 140: 299. DOI: 10.2307/3579106  0.331
1994 Tsang N, Little JB. Effect of Restoration of Retinoblastoma Gene Function on the Radiosensitivity of Cells of Human Tumor Cell Lines Radiation Research. 140: 172. DOI: 10.2307/3578900  0.36
1993 Krolewski B, Little JB. Application of denaturing gradient gel blots to detect p53 mutations in X-ray-transformed mouse C3H 10T1/2 clones. Molecular Carcinogenesis. 7: 190-6. PMID 8489714 DOI: 10.1002/Mc.2940070309  0.351
1993 Kinashi Y, Nagasawa H, Little JB. Cytotoxicity of restriction enzyme-induced DNA strand breaks in radiosensitive and radioresistant human tumor cell lines. International Journal of Radiation Oncology, Biology, Physics. 27: 319-22. PMID 8407406 DOI: 10.1016/0360-3016(93)90243-O  0.364
1993 Dahlberg WK, Little JB, Fletcher JA, Suit HD, Okunieff P. Radiosensitivity in vitro of human soft tissue sarcoma cell lines and skin fibroblasts derived from the same patients International Journal of Radiation Biology. 63: 191-198. PMID 8094415 DOI: 10.1080/09553009314550251  0.387
1993 Kinashi Y, Nagasawa H, Little JB. Mutagenic effects of restriction enzymes in Chinese hamster cells: evidence for high mutagenicity of Sau3AI at the hprt locus. Mutation Research. 285: 251-7. PMID 7678898 DOI: 10.1016/0027-5107(93)90113-T  0.336
1993 Su L, Little JB. Prolonged Cell Cycle Delay in Radioresistant Human Cell Lines Transfected with Activated ras Oncogene and/or Simian Virus 40 T-Antigen Radiation Research. 133: 73. DOI: 10.2307/3578259  0.387
1993 LITTLE JB. Radiorésistance en relation avec l'activation d'oncogène Radioprotection. 28: 73-75. DOI: 10.1051/Radiopro/1993035  0.424
1993 Little JB. Cellular, Molecular, and Carcinogenic Effects of Radiation Hematology/Oncology Clinics of North America. 7: 337-352. DOI: 10.1016/S0889-8588(18)30244-2  0.362
1992 Wiencke JK, Wara DW, Little JB, Kelsey KT. Heterogeneity in the clastogenic response to X-rays in lymphocytes from ataxia-telangiectasia heterozygotes and controls. Cancer Causes & Control : Ccc. 3: 237-45. PMID 1610970 DOI: 10.1007/Bf00124257  0.324
1992 Chang WP, Little JB. Delayed reproductive death as a dominant phenotype in cell clones surviving X-irradiation. Carcinogenesis. 13: 923-8. PMID 1600612 DOI: 10.1093/Carcin/13.6.923  0.399
1992 Li CY, Yandell DW, Little JB. Molecular mechanisms of spontaneous and induced loss of heterozygosity in human cells in vitro. Somatic Cell and Molecular Genetics. 18: 77-87. PMID 1546370 DOI: 10.1007/Bf01233450  0.363
1992 Li CY, Yandell DW, Little JB. Evidence for coincident mutations in human lymphoblast clones selected for functional loss of a thymidine kinase gene. Molecular Carcinogenesis. 5: 270-7. PMID 1497803 DOI: 10.1002/Mc.2940050407  0.355
1992 Nagasawa H, Little JB, Tsang NM, Saunders E, Tesmer J, Strniste GF. Effect of dose rate on the survival of irradiated human skin fibroblasts Radiation Research. 132: 375-379. PMID 1475361 DOI: 10.2307/3578247  0.4
1992 Troilo P, Strong LC, Little JB, Nichols WW. Spontaneous and induced levels of chromosomal aberration and sister-chromatid exchange in neurofibromatosis: no evidence of chromosomal hypersensitivity. Mutation Research. 283: 237-42. PMID 1383795 DOI: 10.1016/0165-7992(92)90054-L  0.326
1992 Chang WP, Little JB. Persistently elevated frequency of spontaneous mutations in progeny of CHO clones surviving X-irradiation: association with delayed reproductive death phenotype. Mutation Research. 270: 191-9. PMID 1383736 DOI: 10.1016/0027-5107(92)90130-T  0.389
1992 Su LN, Little JB. Transformation and radiosensitivity of human diploid skin fibroblasts transfected with SV40 T-antigen mutants defective in RB and P53 binding domains. International Journal of Radiation Biology. 62: 461-8. PMID 1357059 DOI: 10.1080/09553009214552341  0.319
1992 Su LN, Little JB. Transformation and radiosensitivity of human diploid skin fibroblasts transfected with activated ras oncogene and SV40 T-antigen. International Journal of Radiation Biology. 62: 201-10. PMID 1355514 DOI: 10.1080/09553009214552021  0.318
1992 Benjamin MB, Little JB. X rays induce interallelic homologous recombination at the human thymidine kinase gene. Molecular and Cellular Biology. 12: 2730-8. PMID 1350323 DOI: 10.1128/Mcb.12.6.2730  0.369
1992 Dahlberg WK, Little JB. Differential Sensitization of Human Tumor Cells by ara-A to X Irradiation and Its Relationship to Inherent Radioresponse Radiation Research. 130: 303. DOI: 10.2307/3578375  0.401
1992 Chang WP, Little JB. Evidence That DNA Double-Strand Breaks Initiate the Phenotype of Delayed Reproductive Death in Chinese Hamster Ovary Cells Radiation Research. 131: 53. DOI: 10.2307/3578316  0.393
1992 Cox R, Little JB. Oncogenic Cell Transformation in Vitro Advances in Radiation Biology. 16: 137-158. DOI: 10.1016/B978-0-12-035416-0.50010-0  0.315
1991 Little JB, Gorgojo L, Vetrovs H. Delayed appearance of lethal and specific gene mutations in irradiated mammalian cells. International Journal of Radiation Oncology, Biology, Physics. 19: 1425-9. PMID 2262367 DOI: 10.1016/0360-3016(90)90354-M  0.405
1991 Caggana M, Benjamin MB, Little JB, Liber HL, Kelsey KT. Single-strand conformation polymorphisms can be used to detect T cell receptor gene rearrangements: An application to the in vivo hprt mutation assay Mutagenesis. 6: 375-379. PMID 1795641 DOI: 10.1093/Mutage/6.5.375  0.346
1991 Chang WP, Little JB. Delayed reproductive death in X-irradiated Chinese hamster ovary cells. International Journal of Radiation Biology. 60: 483-96. PMID 1679088 DOI: 10.1080/09553009114552331  0.429
1991 Benjamin MB, Potter H, Yandell DW, Little JB. A system for assaying homologous recombination at the endogenous human thymidine kinase gene Proceedings of the National Academy of Sciences of the United States of America. 88: 6652-6656. PMID 1677771 DOI: 10.1073/Pnas.88.15.6652  0.331
1990 Rutz HP, Little JB. Retinoic acid inhibits the fixation of initial transformational damage in X-irradiated Balb/3T3 mouse fibroblasts in vitro. Carcinogenesis. 10: 2183-6. PMID 2591007 DOI: 10.1093/Carcin/10.12.2183  0.383
1990 Kano Y, Little JB. Efficient immortalization by SV40 T DNA of skin fibroblasts from patients with Wilms' tumor associated with chromosome 11p deletion. Molecular Carcinogenesis. 2: 314-21. PMID 2559742 DOI: 10.1002/Mc.2940020606  0.358
1990 Nagasawa H, Little JB, Inkret WC, Carpenter S, Thompson K, Raju MR, Chen DJ, Strniste GF. Cytogenetic effects of extremely low doses of plutonium-238 alpha-particle irradiation in CHO K-1 cells. Mutation Research. 244: 233-8. PMID 2366817 DOI: 10.1016/0165-7992(90)90134-6  0.357
1990 Whaley JM, Little JB. Molecular characterization of hprt mutants induced by low- and high-LET radiations in human cells. Mutation Research. 243: 35-45. PMID 2300083 DOI: 10.1016/0165-7992(90)90120-9  0.42
1990 Little JB. Low-dose radiation effects: interactions and synergism. Health Physics. 59: 49-55. PMID 2193003 DOI: 10.1097/00004032-199007000-00005  0.387
1990 Whaley JM, Kassis AI, Kinsey BM, Adelstein SJ, Little JB. Mutation induction by 125iodoacetylproflavine, a DNA-intercalating agent, in human cells. International Journal of Radiation Biology. 57: 1087-103. PMID 1971836 DOI: 10.1080/09553009014551211  0.405
1990 Yandell DW, Dryja TP, Little JB. Molecular genetic analysis of recessive mutations at a heterozygous autosomal locus in human cells. Mutation Research. 229: 89-102. PMID 1969112 DOI: 10.1016/0027-5107(90)90011-R  0.322
1990 Nagasawa H, Robertson J, Little JB. Induction of chromosomal aberrations and sister chromatid exchanges by alpha particles in density-inhibited cultures of mouse 10T1/2 and 3T3 cells. International Journal of Radiation Biology. 57: 35-44. PMID 1967292 DOI: 10.1080/09553009014550321  0.392
1990 Rutz HP, Little JB. Exogenous Lactate Modifies the Repair of Potentially Lethal Damage in Three Human Tumor Cell Lines Irradiated in Vitro Radiation Research. 124: 110. DOI: 10.2307/3577704  0.367
1990 Little JB, Nove J. Sensitivity of Human Diploid Fibroblast Cell Strains from Various Genetic Disorders to Acute and Protracted Radiation Exposure Radiation Research. 123: 87. DOI: 10.2307/3577662  0.406
1990 Whaley JM, Little JB. Efficient Mutation Induction by 125 I and 131 I Decays in DNA of Human Cells Radiation Research. 123: 68. DOI: 10.2307/3577659  0.402
1990 Loeffler JS, Harris JR, Dahlberg WK, Little JB. In Vitro Radiosensitivity of Human Diploid Fibroblasts Derived from Women with Unusually Sensitive Clinical Responses to Definitive Radiation Therapy for Breast Cancer Radiation Research. 121: 227. DOI: 10.2307/3577508  0.335
1989 Frenial JM, Coppey J, Little JB. Toxicity and mutual interactions of cadmium and zinc ions in normal and carcinogen-transformed mouse cells. Cell Biology and Toxicology. 2: 1-8. PMID 3267441 DOI: 10.1007/Bf00117702  0.346
1989 Kronenberg A, Little JB. Molecular characterization of thymidine kinase mutants of human cells induced by densely ionizing radiation. Mutation Research. 211: 215-24. PMID 2927407 DOI: 10.1016/0027-5107(89)90004-3  0.343
1989 Rudolph NS, Nagasawa H, Little JB, Latt SA. Identification of ataxia telangiectasia heterozygotes by flow cytometric analysis of X-ray damage Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 211: 19-29. PMID 2922000 DOI: 10.1016/0027-5107(89)90103-6  0.373
1989 Liber HL, Yandell DW, Little JB. A comparison of mutation induction at the tk and hprt loci in human lymphoblastoid cells; quantitative differences are due to an additional class of mutations at the autosomal tk locus Mutation Research/Environmental Mutagenesis and Related Subjects. 216: 9-17. PMID 2918864 DOI: 10.1016/0165-1161(89)90018-6  0.341
1989 Little JB, Frenial JM, Coppey J. Studies of mutagenesis and neoplastic transformation by bivalent metal ions and ionizing radiation. Teratogenesis, Carcinogenesis, and Mutagenesis. 8: 287-92. PMID 2905837 DOI: 10.1002/Tcm.1770080505  0.363
1989 Little JB, Nove J, Strong LC, Nichols WW. Survival of human diploid skin fibroblasts from normal individuals after X-irradiation. International Journal of Radiation Biology. 54: 899-910. PMID 2903888 DOI: 10.1080/09553008814552311  0.326
1989 Krolewski B, Little JB. Molecular analysis of DNA isolated from the different stages of x-ray-induced transformation in vitro. Molecular Carcinogenesis. 2: 27-33. PMID 2730762 DOI: 10.1002/Mc.2940020105  0.382
1989 Liber HL, Benforado K, Little JB. The molecular nature of mutants induced by X rays is altered by the presence of the radioprotector cysteamine Radiation Research. 118: 324-329. PMID 2727260 DOI: 10.2307/3577446  0.321
1989 Rutz HP, Little JB. Modification of radiosensitivity and recovery from X ray damage in vitro by retinoic acid. International Journal of Radiation Oncology, Biology, Physics. 16: 1285-8. PMID 2715081 DOI: 10.1016/0360-3016(89)90300-3  0.37
1989 Yandell DW, Campbell TA, Dayton SH, Petersen R, Walton D, Little JB, McConkie-Rosell A, Buckley EG, Dryja TP. Oncogenic point mutations in the human retinoblastoma gene: their application to genetic counseling. The New England Journal of Medicine. 321: 1689-95. PMID 2594029 DOI: 10.1056/Nejm198912213212501  0.31
1989 Kronenberg A, Little JB. Locus specificity for mutation induction in human cells exposed to accelerated heavy ions. International Journal of Radiation Biology. 55: 913-24. PMID 2567330 DOI: 10.1080/09553008914550961  0.305
1989 Gorgojo L, Little JB. Expression of lethal mutations in progeny of irradiated mammalian cells. International Journal of Radiation Biology. 55: 619-30. PMID 2564871 DOI: 10.1080/09553008914550661  0.436
1989 Little JB, Ueno AM, Dahlberg WK. Differential response of human and rodent cell lines to chemical inhibition of the repair of potentially lethal damage. Radiation and Environmental Biophysics. 28: 193-202. PMID 2508186 DOI: 10.1007/Bf01211256  0.395
1989 Rutz HP, Little JB. Age-Dependent Modification by Lactate of Repair of Potentially Lethal Damage in Normal Human Diploid Fibroblasts Radiation Research. 118: 525. DOI: 10.2307/3577410  0.365
1988 Little JB, Vetrovs H. Studies of ionizing radiation as a promoter of neoplastic transformation in vitro. International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine. 53: 661-6. PMID 3258299 DOI: 10.1080/09553008814550981  0.382
1988 Nagasawa H, Fornace AJ, Little JB. Recovery of mitomycin C-treated mouse 10T1/2 cells during confluent holding. Mutation Research. 198: 153-60. PMID 3127697 DOI: 10.1016/0027-5107(88)90050-4  0.575
1988 Krolewski B, Little JB, Reynolds RJ. Effect of duration of exposure to benzo(a)pyrene diol-epoxide on neoplastic transformation, mutagenesis, cytotoxicity, and total covalent binding to DNA of rodent cells Teratogenesis Carcinogenesis and Mutagenesis. 8: 127-136. PMID 2905079 DOI: 10.1002/Tcm.1770080302  0.393
1988 Nagasawa H, Burke MJ, Little FF, McCone EF, Chan GL, Little JB. Multiple abnormalities in the ultraviolet light response of cultured fibroblasts derived from patients with the basal cell nevus syndrome. Teratogenesis, Carcinogenesis, and Mutagenesis. 8: 25-33. PMID 2897722 DOI: 10.1002/Tcm.1770080104  0.453
1987 Corn BW, Liber HL, Little JB. Differential effects of radical scavengers on X-ray-induced mutation and cytotoxicity in human cells Radiation Research. 109: 100-108. PMID 3809384 DOI: 10.2307/3576871  0.439
1987 Nagasawa H, Zamansky GB, McCone EF, Arundel CM, Matkin E, Little JB. Spontaneous transformation to anchorage-independent growth of a xeroderma pigmentosum fibroblast cell strain. The Journal of Investigative Dermatology. 88: 149-53. PMID 3805755 DOI: 10.1111/1523-1747.Ep12525294  0.395
1987 Kano Y, Grosovsky AJ, Little JB. Interrelationships among X‐ray‐induced anchorage independence, mutagenesis and chromosomal rearrangements in human diploid fibroblasts International Journal of Cancer. 40: 64-68. PMID 3596833 DOI: 10.1002/Ijc.2910400112  0.309
1987 Kelsey KT, Nagasawa H, Umans RS, Little JB. Epidermal growth factor induces cytogenetic damage in mammalian cells. Carcinogenesis. 8: 625-7. PMID 3493863 DOI: 10.1093/Carcin/8.4.625  0.339
1987 Liber HL, Call KM, Little JB. Molecular and biochemical analyses of spontaneous and X-ray induced mutants in human lymphoblastoid cells Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 178: 143-153. PMID 3033487 DOI: 10.1016/0027-5107(87)90096-0  0.353
1987 Nove J, Tarone RE, Little JB, Robbins JH. Radiation sensitivity of fibroblast strains from patients with Usher's syndrome, Duchenne muscular dystrophy, and Huntington's disease. Mutation Research. 184: 29-38. PMID 2955220 DOI: 10.1016/0167-8817(87)90033-2  0.35
1986 Little JB, Nagasawa H, Weichselbaum RR, Lovett DR, Schmit A, Kochenburger RJ, Blumberg PM. Differing patterns of cytotoxicity of the phorbol ester 12-O-tetradecanoylphorbol 13-acetate in various human cell strains. Carcinogenesis. 6: 1703-8. PMID 3864565 DOI: 10.1093/Carcin/6.12.1703  0.381
1986 Nove J, Little JB, Mayer PJ, Troilo P, Nichols WW. Hypersensitivity of cells from a new chromosomal-breakage syndrome to DNA-damaging agents. Mutation Research. 163: 255-62. PMID 3785261 DOI: 10.1016/0027-5107(86)90023-0  0.396
1986 Little JB. Characteristics of radiation-induced neoplastic transformation in vitro. Leukemia Research. 10: 719-25. PMID 3736107 DOI: 10.1016/0145-2126(86)90281-X  0.43
1986 Krolewski B, Nagasawa H, Little JB. Effect of aliphatic amides on oncogenic transformation, sister chromatid exchanges, and mutations induced by cyclopenta[cd]-pyrene and benzo[a]pyrene. Carcinogenesis. 7: 1647-50. PMID 3093110 DOI: 10.1093/Carcin/7.10.1647  0.328
1986 Yandell DW, Little JB. Chromosome 14 marker appearance in a human B lymphoblastoid cell line of nonmalignant origin. Cancer Genetics and Cytogenetics. 20: 231-9. PMID 3080224 DOI: 10.1016/0165-4608(86)90078-6  0.35
1986 Liber HL, Leong PM, Terry VH, Little JB. X-rays mutate human lymphoblast cells at genetic loci that should respond only to point mutagens Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 163: 91-97. PMID 3018557 DOI: 10.1016/0027-5107(86)90062-X  0.314
1986 Kelsey KT, Yano E, Liber HL, Little JB. The in vitro genetic effects of fibrous erionite and crocidolite asbestos British Journal of Cancer. 54: 107-114. PMID 3015180 DOI: 10.1038/Bjc.1986.158  0.348
1986 Yandell DW, Dryja TP, Little JB. Somatic mutations at a heterozygous autosomal locus in human cells occur more frequently by allele loss than by intragenic structural alterations. Somatic Cell and Molecular Genetics. 12: 255-63. PMID 3012798 DOI: 10.1007/Bf01570784  0.315
1986 Albert DM, Walton DS, Weichselbaum RR, Robert Cassady J, Little JB, Leombruno D, Trantravahi R, Puliafito CA. Fibroblast radiosensitivity and intraocular fibrovascular proliferation following radiotherapy for bilateral retinoblastoma British Journal of Ophthalmology. 70: 336-342. PMID 2421761 DOI: 10.1097/00006982-198600630-00018  0.353
1986 Little JB. Induction of Neoplastic Transformation by Low-Dose-Rate Exposure to Tritiated Water Radiation Research. 107: 225. DOI: 10.2307/3576810  0.366
1985 Nagasawa H, Little FF, Burke MJ, McCone EF, Targovnik HS, Chan GL, Little JB. Study of basal cell nevus syndrome fibroblasts after treatment with DNA-damaging agents. Basic Life Sciences. 775-85. PMID 6442144 DOI: 10.1007/978-1-4684-4892-4_20  0.417
1985 Grosovsky AJ, Little JB. Confluent holding leads to a transient enhancement in mutagenesis in UV-light-irradiated xeroderma pigmentosum, Gardner's syndrome and normal human diploid fibroblasts Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 149: 147-155. PMID 3974621 DOI: 10.1016/0027-5107(85)90020-X  0.406
1985 Nagasawa H, Latt SA, Lalande ME, Little JB. Effects of X-irradiation on cell-cycle progression, induction of chromosomal aberrations and cell killing in ataxia telangiectasia (AT) fibroblasts. Mutation Research. 148: 71-82. PMID 3969079 DOI: 10.1016/0027-5107(85)90209-X  0.416
1985 Liber HL, Ozaki VH, Little JB. Toxicity and mutagenicity of low dose rates of ionizing radiation from tritiated water in human lymphoblastoid cells Mutation Research/Genetic Toxicology. 157: 77-86. PMID 3925333 DOI: 10.1016/0165-1218(85)90052-7  0.364
1985 Schwenn MR, Weichselbaum RR, Little JB. Investigation of the cytotoxic effects of DNA damaging agents on neurofibromatosis cells. Mutation Research. 142: 55-8. PMID 3919286 DOI: 10.1016/S0165-7992(85)80013-0  0.402
1985 Krolewski B, Little JB. Influence of isopropylvaleramide and allylisopropylacetamide on transformation of C3H/10T1/2 cells induced by benzo[a]pyrene derivatives. Carcinogenesis. 6: 7-11. PMID 3917871 DOI: 10.1093/Carcin/6.1.7  0.303
1985 Little JB. Mutagenic and chromosomal events in radiation transformation. Biochimie. 67: 405-15. PMID 3899193 DOI: 10.1016/S0300-9084(85)80089-4  0.445
1985 Nagasawa H, Little JB. Changes in frequencies of chromosomal aberrations and sister chromatid exchanges during confluent holding recovery in X-irradiated normal human diploid fibroblasts. International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine. 48: 597-602. PMID 3876310 DOI: 10.1080/09553008514551651  0.367
1985 Weichselbaum RR, Dahlberg W, Little JB. Inherently radioresistant cells exist in some human tumors. Proceedings of the National Academy of Sciences of the United States of America. 82: 4732-5. PMID 3860821 DOI: 10.1073/Pnas.82.14.4732  0.376
1985 Grosovsky AJ, Little JB. Evidence for linear response for the induction of mutations in human cells by x-ray exposures below 10 rads Proceedings of the National Academy of Sciences of the United States of America. 82: 2092-2095. PMID 3856885 DOI: 10.1073/Pnas.82.7.2092  0.378
1985 Little JB, Kennedy AR, McGandy RB. Effect of Dose Rate on the Induction of Experimental Lung Cancer in Hamsters by α Radiation Radiation Research. 103: 293. DOI: 10.2307/3576584  0.331
1985 Little JB, Nagasawa H. Effect of Confluent Holding on Potentially Lethal Damage Repair, Cell Cycle Progression, and Chromosomal Aberrations in Human Normal and Ataxia-Telangiectasia Fibroblasts Radiation Research. 101: 81. DOI: 10.2307/3576305  0.441
1985 Weichselbaum R, Tomkinson K, Little J. Repair of Potentially Lethal X-ray Damage in Fibroblasts Derived from Patients with Hereditary and D-deletion Retinoblastoma International Journal of Radiation Biology. 47: 445-456. DOI: 10.1080/713860603  0.415
1985 KANO Y, LITTLE JB. MECHANISMS OF HUMAN CELL NEOPLASTIC TRANSFORMATION: RELATIONSHIP OF SPECIFIC ABNORMAL CLONE FORMATION TO PROLONGED LIFESPAN IN X-IRRADIATED HUMAN DIPLOID FIBROBLASTS International Journal of Cancer. 36: 407-414. DOI: 10.1002/Ijc.1985.36.3.407  0.36
1984 Weichselbaum R, Dahlberg W, Little JB, Ervin TJ, Miller D, Hellman S, Rheinwald JG. Cellular X-ray repair parameters of early passage squamous cell carcinoma lines derived from patients with known responses to radiotherapy. British Journal of Cancer. 49: 595-601. PMID 6722007 DOI: 10.1038/Bjc.1984.94  0.362
1984 Kennedy AR, Cairns J, Little JB. Timing of the steps in transformation of C3H 10T 1/2 cells by X-irradiation. Nature. 307: 85-6. PMID 6690989 DOI: 10.1038/307085A0  0.363
1984 Weichselbaum RR, Little JB, Tomkinson K, Evans S, Yuhas J. Repair of fractionated radiation in plateau phase cultures of human tumor cells and human multicellular tumor spheroids. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 2: 41-7. PMID 6505275 DOI: 10.1016/S0167-8140(84)80037-7  0.39
1984 Guichard M, Weichselbaum RR, Little JB, Malaise EP. Potentially lethal damage repair as a possible determinant of human tumour radiosensitivity. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 1: 263-9. PMID 6505262 DOI: 10.1016/S0167-8140(84)80009-2  0.374
1984 Kennedy AR, Troll W, Little JB. Role of free radicals in the initiation and promotion of radiation transformation in vitro. Carcinogenesis. 5: 1213-8. PMID 6488446 DOI: 10.1093/Carcin/5.10.1213  0.345
1984 Kennedy AR, Little JB. Evidence That a Second Event in X-Ray-Induced Oncogenic Transformation in Vitro Occurs during Cellular Proliferation Radiation Research. 99: 228. DOI: 10.2307/3576368  0.388
1984 Nagasawa H, Robertson JB, Arundel CS, Little JB. The Effect of X Irradiation on the Progression of Mouse 10T 1/2 Cells Released from Density-Inhibited Cultures Radiation Research. 97: 537. DOI: 10.2307/3576145  0.36
1983 Chan GL, Little JB. Effects of fluence fractionation on UV-induced malignant transformation and cell killing in non-cycling plateau phase mouse cells. Photochemistry and Photobiology. 36: 409-11. PMID 7146111 DOI: 10.1111/J.1751-1097.1982.Tb04394.X  0.364
1983 Weichselbaum RR, Little JB. The differential response of human tumours to fractionated radiation may be due to a post-irradiation repair process. British Journal of Cancer. 46: 532-7. PMID 7138762 DOI: 10.1038/Bjc.1982.237  0.429
1983 LeMotte PK, Adelstein SJ, Little JB. Malignant transformation induced by incorporated radionuclides in BALB/3T3 mouse embryo fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 79: 7763-7. PMID 6961448 DOI: 10.1073/Pnas.79.24.7763  0.402
1983 Weichselbaum RR, Nichols WW, Albert DM, Little JB. In vitro radiosensitivity of fibroblasts derived from patients with retinoblastoma and abnormalities of chromosome 13. Retina (Philadelphia, Pa.). 3: 126-30. PMID 6878899 DOI: 10.1097/00006982-198300320-00011  0.363
1983 Grosovsky AJ, Little JB. Influence of confluent holding time on UV light mutagenesis in human diploid fibroblasts Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 110: 401-412. PMID 6877263 DOI: 10.1016/0027-5107(83)90156-2  0.354
1983 Nagasawa H, Little JB. Comparison of kinetics of X-ray-induced cell killing in normal, ataxia telangiectasia and hereditary retinoblastoma fibroblasts. Mutation Research. 109: 297-308. PMID 6843573 DOI: 10.1016/0027-5107(83)90054-4  0.422
1983 Weichselbaum RR, Little JB. Repair of potentially lethal X ray damage and possible applications to clinical radiotherapy. International Journal of Radiation Oncology, Biology, Physics. 9: 91-6. PMID 6841181 DOI: 10.1016/0360-3016(83)90215-8  0.321
1983 Barfknecht TR, Little JB. Survival of hereditary retinoblastoma human skin fibroblasts after treatment with DNA-damaging chemicals. Mutation Research. 105: 189-94. PMID 6815522 DOI: 10.1016/0165-7992(82)90010-0  0.302
1983 Henson P, Fornace AJ, Little JB. Normal repair of ultraviolet-induced DNA damage in a hypersensitive strain of fibroblasts from a patient with Gardner's syndrome. Mutation Research. 112: 383-95. PMID 6656799 DOI: 10.1016/0167-8817(83)90031-7  0.555
1983 Liber HL, LeMotte PK, Little JB. Toxicity and mutagenicity of X-rays and [125I]dUrd or [3H]TdR incorporated in the DNA of human lymphoblast cells Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 111: 387-404. PMID 6646149 DOI: 10.1016/0027-5107(83)90035-0  0.408
1983 Grosovsky AJ, Little JB. Mutagenesis and lethality following S phase irradiation of xeroderma pigmentosum and normal human diploid fibroblasts with ultraviolet light Carcinogenesis. 4: 1389-1393. PMID 6640842 DOI: 10.1093/Carcin/4.11.1389  0.339
1983 Weichselbaum RR, Withers HR, Tomkinson K, Little J. Potentially lethal damage repair (PLDR) in x-irradiated cultures of a normal human diploid fibroblast cell strain International Journal of Radiation Biology. 43: 313-319. PMID 6601080 DOI: 10.1080/09553008314550351  0.395
1983 Li FP, Little JB, Bech-Hansen NT, Paterson MC, Arlett C, Garnick MB, Mayer RJ. Acute leukemia after radiotherapy in a patient with Turcot's syndrome. Impaired colony formation in skin fibroblast cultures after irradiation. The American Journal of Medicine. 74: 343-8. PMID 6572034 DOI: 10.1016/0002-9343(83)90643-5  0.34
1983 Nagasawa H, Little JB. Suppression of cytotoxic effect of mitomycin-C by superoxide dismutase in Fanconi's anemia and dyskeratosis congenita fibroblasts. Carcinogenesis. 4: 795-9. PMID 6409437 DOI: 10.1093/Carcin/4.7.795  0.335
1983 Nagasawa H, Fornace D, Little JB. Induction of sister-chromatid exchanges by DNA-damaging agents and 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in synchronous Chinese hamster ovary (CHO) cells. Mutation Research. 107: 315-27. PMID 6408470 DOI: 10.1016/0027-5107(83)90173-2  0.382
1983 Heidelberger C, Freeman AE, Pienta RJ, Sivak A, Bertram JS, Casto BC, Dunkel VC, Francis MW, Kakunaga T, Little JB, Schechtman LM. Cell transformation by chemical agents--a review and analysis of the literature. A report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutation Research. 114: 283-385. PMID 6339891 DOI: 10.1016/0165-1110(83)90036-2  0.355
1983 Griem K, Weichselbaum RR, Umans RS, Gifford L, Little JB. Work in progress: radioprotection of human breast cancer cells by elevation of intracellular cyclic AMP. Radiology. 148: 289-90. PMID 6190195 DOI: 10.1148/Radiology.148.1.6190195  0.357
1983 LeMotte PK, Little JB. A Comparison of the Lethal Effects of Intracellular Radionuclides in Human and Rodent Cells Radiation Research. 95: 359. DOI: 10.2307/3576261  0.363
1983 Robertson JB, Koehler A, George J, Little JB. Oncogenic Transformation of Mouse BALB/3T3 Cells by Plutonium-238 Alpha Particles Radiation Research. 96: 261. DOI: 10.2307/3576209  0.419
1982 Chan GL, Little JB. Complex interactions of caffeine and its structural analogs with ultraviolet light in cell killing. Mutation Research. 84: 191-201. PMID 7329433 DOI: 10.1016/0027-5107(81)90062-2  0.379
1982 Nove J, Nichols WW, Weichselbaum RR, Little JB. Abnormalities of human chromosome 13 and in vitro radiosensitivity; a study of 19 fibroblast strains. Mutation Research. 84: 157-67. PMID 7329430 DOI: 10.1016/0027-5107(81)90059-2  0.322
1982 Chan GL, Little JB. The influence of cellular proliferative history on the susceptibility to oncogenic transformation. Journal of Cellular Physiology. 109: 317-22. PMID 7298731 DOI: 10.1002/Jcp.1041090215  0.36
1982 Weichselbaum RR, Little JB. Radioresistance in some human tumor cells conferred in vitro by repair of potentially lethal X-ray damage. Radiology. 145: 511-3. PMID 7134460 DOI: 10.1148/Radiology.145.2.7134460  0.39
1982 Chan GL, Little JB. Dissociated occurrence of single-gene mutation and oncogenic transformation in C3H 10T1/2 cells exposed to ultraviolet light and caffeine. Journal of Cellular Physiology. 111: 309-14. PMID 7096454 DOI: 10.1002/Jcp.1041110313  0.378
1982 Chan GL, Little JB. Modulation of survival and transformation during plateau-phase holding of UV-irradiated mouse cells. Mutation Research. 104: 183-6. PMID 7078572 DOI: 10.1016/0165-7992(82)90142-7  0.386
1982 Weichselbaum RR, Schmit A, Little JB. Cellular repair factors influencing radiocurability of human malignant tumours. British Journal of Cancer. 45: 10-6. PMID 7059452 DOI: 10.1038/Bjc.1982.2  0.377
1982 Shami SG, Thibodeau LA, Kennedy AR, Little JB. Recovery from ozone-induced injury in the lungs of the Syrian golden hamster. Experimental and Molecular Pathology. 36: 57-71. PMID 7056371 DOI: 10.1016/0014-4800(82)90079-X  0.35
1982 Weichselbaum RR, Malcolm AW, Little JB. Fraction size and the repair of potentially lethal radiation damage in a human melanoma cell line. Possible implications for radiotherapy. Radiology. 142: 225-7. PMID 7053535 DOI: 10.1148/Radiology.142.1.7053535  0.415
1982 Chan GL, Little JB. Further studies on the survival of non-proliferating human diploid fibroblasts irradiated with ultraviolet light. International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine. 41: 359-68. PMID 6978859 DOI: 10.1080/09553008214550411  0.362
1982 Nagasawa H, Fornace AJ, Ritter MA, Little JB. Relationship of enhanced survival during confluent holding recovery in ultraviolet-irradiated human and mouse cells to chromosome aberrations, sister chromatid exchanges, and DNA repair. Radiation Research. 92: 483-96. PMID 6294721 DOI: 10.2307/3575921  0.594
1982 Zamansky GB, Little JB. Survival of 60Co-irradiated herpes simplex virus in 15 human diploid fibroblast cell strains. Mutation Research. 94: 245-55. PMID 6287252 DOI: 10.1016/0027-5107(82)90288-3  0.381
1982 Long SD, Warren AJ, Little JB. Effect of nonoxynol-9, a detergent with spermicidal activity, on malignant transformation in vitro Carcinogenesis. 3: 553-557. PMID 6284403 DOI: 10.1093/Carcin/3.5.553  0.31
1982 Weichselbaum RR, Nove J, Albert D, Little JB. An in vitro investigation of genetic susceptibility to cancer in diploid fibroblasts from retinoblastoma patients. Teratogenesis, Carcinogenesis, and Mutagenesis. 1: 171-9. PMID 6119809 DOI: 10.1002/Tcm.1770010206  0.353
1982 Malcolm AW, Tomkinson KN, Little JB. Characterization of Rapid Recovery from γ-Ray Damage in Plateau-Phase Human Diploid Fibroblasts Radiation Research. 89: 274. DOI: 10.2307/3575773  0.367
1982 Kinsella TJ, Little JB, Nove J, Weichselbaum RR, Li FP, Meyer RJ, Marchetto DJ, Patterson WB. Heterogeneous Response to X-Ray and Ultraviolet Light Irradiations of Cultured Skin Fibroblasts in Two Families With Gardner's Syndrome Journal of the National Cancer Institute. 68: 697-701. DOI: 10.1093/Jnci/68.5.697  0.333
1981 Zimmerman RJ, Little JB. Starvation for arginine and glutamine sensitizes human diploid cells to the transforming effects of N-acetoxy-2-acetyl-aminofluorene Carcinogenesis. 2: 1303-1310. PMID 7326831 DOI: 10.1093/Carcin/2.12.1303  0.386
1981 Nagasawa H, Little JB. Factors influencing the induction of sister chromatid exchanges in mammalian cells by 12-O-tetradecanoyl-phorbol-13-acetate. Carcinogenesis. 2: 601-7. PMID 7273339 DOI: 10.1093/Carcin/2.7.601  0.345
1981 Fisher PB, Mufson RA, Weinstein IB, Little JB. Epidermal growth factor, like tumor promoters, enhances viral and radiation-induced cell transformation Carcinogenesis. 2: 183-187. PMID 6974060 DOI: 10.1093/Carcin/2.3.183  0.379
1981 Cox R, Masson WK, Weichselbaum RR, Nove J, Little JB. The repair of potentially lethal damage in x-irradiated cultures of normal and ataxia telangiectasia human fibroblasts. International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine. 39: 357-65. PMID 6971846 DOI: 10.1080/09553008114550461  0.347
1981 Kennedy AR, Little JB. Actinomycin D suppresses radiation transformation in vitro. International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine. 38: 465-8. PMID 6969236 DOI: 10.1080/09553008014551831  0.311
1981 Malcolm AW, Little JB. Rapid recovery in human diploid fibroblasts. International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine. 38: 439-47. PMID 6969234 DOI: 10.1080/09553008014551801  0.35
1981 Chan GL, Little JB. Cross-sensitivity of certain xeroderma pigmentosum and Cockayne syndrome fibroblast strains to both ionizing radiation and ultraviolet light. Molecular & General Genetics : Mgg. 181: 562-3. PMID 6943407 DOI: 10.1007/Bf00428755  0.307
1981 Weichselbaum RR, Greenberger JS, Schmidt A, Karpas A, Moloney WC, Little JB. In vitro radiosensitivity of human leukemia cell lines. Radiology. 139: 485-7. PMID 6939019 DOI: 10.1148/Radiology.139.2.6939019  0.303
1981 Clark EP, Hahn GM, Little JB. Hyperthermic Modulation of X-Ray-Induced Oncogenic Transformation in C3H 10T 1/2 Cells Radiation Research. 88: 619. DOI: 10.2307/3575650  0.332
1981 Little JB. Influence of Noncarcinogenic Secondary Factors on Radiation Carcinogenesis Radiation Research. 87: 240. DOI: 10.2307/3575581  0.425
1981 Nagasawa H, Little JB. Induction of Chromosome Aberrations and Sister Chromatid Exchanges by X Rays in Density-Inhibited Cultures of Mouse 10T 1/2 Cells Radiation Research. 87: 538. DOI: 10.2307/3575519  0.385
1980 Fornace AJ, Little JB. Malignant transformation by the DNA-protein crosslinking agent trans-Pt(II) diamminedichloride. Carcinogenesis. 1: 989-94. PMID 11272115 DOI: 10.1093/Carcin/1.12.989  0.541
1980 Weichselbaum RR, Little JB, Nove J, Hellman S, Piro AJ. Lack of selective killing by steroids in normal and malignant cells. Journal of Cellular Physiology. 103: 429-33. PMID 7400225 DOI: 10.1002/Jcp.1041030308  0.325
1980 Fornace AJ, Nagasawa H, Little JB. Relationship of DNA repair to chromosome aberrations, sister-chromatid exchanges and survival during liquid-holding recovery in X-irradiated mammalian cells. Mutation Research. 70: 323-36. PMID 7383039 DOI: 10.1016/0027-5107(80)90022-6  0.563
1980 Little JB, Nove J, Weichselbaum RR. Abnormal sensitivity of diploid skin fibroblasts from a family with gardner's syndrome to the lethal effects of X-irradiation, ultraviolet light and mitomycin-C. Mutation Research. 70: 241-50. PMID 7374661 DOI: 10.1016/0027-5107(80)90164-5  0.357
1980 Weichselbaum RR, Little JB. Familial retinoblastoma and ataxia telangiectasia: human models for the study of DNA damage and repair. Cancer. 45: 775-9. PMID 7357494 DOI: 10.1002/1097-0142(19800215)45:4<775::Aid-Cncr2820450427>3.0.Co;2-6  0.336
1980 Kennedy AR, Ritter MA, Little JB. Fluorescent light induces malignant transformation in mouse embryo cell cultures. Science (New York, N.Y.). 207: 1209-11. PMID 7355282 DOI: 10.1126/Science.7355282  0.348
1980 Fornace AJ, Nagasawa H, Little JB. Relationship of DNA repair and chromosome aberrations to potentially lethal damage repair in X-irradiated mammalian cells. Basic Life Sciences. 15: 267-83. PMID 7213316 DOI: 10.1007/978-1-4684-3842-0_18  0.565
1980 Kennedy AR, Fox M, Murphy G, Little JB. Relationship between x-ray exposure and malignant transformation in C3H 10T 1/2 cells Proceedings of the National Academy of Sciences of the United States of America. 77: 7262-7266. PMID 6938973 DOI: 10.1073/Pnas.77.12.7262  0.403
1980 Weichselbaum RR, Nove J, Little JB. X-ray sensitivity of human tumor cells in vitro. International Journal of Radiation Oncology, Biology, Physics. 6: 437-40. PMID 6930370 DOI: 10.1016/0360-3016(80)90057-7  0.363
1980 Fornace AJ, Little JB. Normal repair of DNA single-strand breaks in patients with ataxia telangiectasia. Biochimica Et Biophysica Acta. 607: 432-7. PMID 6156701 DOI: 10.1016/0005-2787(80)90153-7  0.548
1980 Weichselbaum RR, Nove J, Hellman S, Piro AJ, Little JB. Combination hormonal, chemotherapy and radiotherapy in vitro: implications for therapy in vivo. International Journal of Radiation Oncology, Biology, Physics. 5: 1657-61. PMID 536273 DOI: 10.1016/0360-3016(79)90792-2  0.352
1980 Chan GL, Little JB. Resistance of plateau-phase human normal and xeroderma pigmentosum fibroblasts to the cytotoxic effect of ultraviolet light. Mutation Research. 63: 401-12. PMID 522880 DOI: 10.1016/0027-5107(79)90072-1  0.388
1980 Weichselbaum RR, Little JB. Effect of 17 beta estradiol (17BE) on the repair of potentially lethal X-ray damage in human breast cancer cell International Journal of Radiation Oncology*Biology*Physics. 6: 1359. DOI: 10.1016/0360-3016(80)90444-7  0.327
1979 Chan GL, Little JB. Correlation of in vitro transformation with in vivo tumorigenicity in 10T1/2 mouse cells exposed to UV light. British Journal of Cancer. 39: 590-3. PMID 486316 DOI: 10.1038/Bjc.1979.107  0.318
1979 Nove J, Little JB, Weichselbaum RR, Nichols WW, Hoffman E. Retinoblastoma, chromosome 13, and in vitro cellular radiosensitivity. Cytogenetics and Cell Genetics. 24: 176-84. PMID 477414 DOI: 10.1159/000131374  0.325
1979 Fornace AJ, Little JB, Weichselbaum RR. DNA repair in a Fanconi's anemia fibroblast cell strain. Biochimica Et Biophysica Acta. 561: 99-109. PMID 420857 DOI: 10.1016/0005-2787(79)90494-5  0.596
1979 Chan GL, Little JB. Response of plateau-phase mouse embryo fibroblasts to ultra-violet light. International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine. 35: 101-10. PMID 312781 DOI: 10.1080/09553007914550121  0.342
1979 Nagasawa H, Little JB. Effect of tumor promoters, protease inhibitors, and repair processes on x-ray-induced sister chromatid exchanges in mouse cells. Proceedings of the National Academy of Sciences of the United States of America. 76: 1943-7. PMID 287035 DOI: 10.1073/Pnas.76.4.1943  0.378
1979 Fornace AJ, Little JB. DNA-protein cross-linking by chemical carcinogens in mammalian cells. Cancer Research. 39: 704-10. PMID 106958  0.442
1979 Malcolm AW, Little JB. Rapid Recovery in Plateau-Phase Mammalian Cells Radiation Research. 80: 38. DOI: 10.2307/3575114  0.407
1979 Little JB, Nagasawa H, Kennedy AR. DNA Repair and Malignant Transformation: Effect of X Irradiation, 12-O-Tetradecanoyl-Phorbol-13-Acetate, and Protease Inhibitors on Transformation and Sister-Chromatid Exchanges in Mouse 10T 1/2 Cells Radiation Research. 79: 241. DOI: 10.2307/3575095  0.405
1979 West G, Weichselbaum RR, Nagasawa H, Little JB. Methotrexate penetration of human osteogenic sarcoma multitumor cell spheroids: an in vitro model for micrometastases and adjuvant chemotherapy International Journal of Radiation Oncology*Biology*Physics. 5: 84-85. DOI: 10.1016/0360-3016(79)90381-X  0.322
1979 Greenberger JS, Weischselbaum RR, Karpas A, Schmitt A, Little JB, Moloney WC. Radiosensitivity of human hematopoietic cell lines of distinguishable stages of biochemical and physiological differentiation International Journal of Radiation Oncology*Biology*Physics. 5: 78. DOI: 10.1016/0360-3016(79)90374-2  0.309
1978 Lampidis TJ, Little JB. Enhancement of UV-induced unscheduled DNA synthesis by hydroxyurea. Demonstration by combined biochemical and autoradiographic techniques. Experimental Cell Research. 110: 41-6. PMID 923664 DOI: 10.1016/0014-4827(77)90267-1  0.36
1978 Desrosiers A, Kennedy A, Little JB. 222Rn daughter dosimetry in the Syrian golden hamster lung. Health Physics. 35: 607-23. PMID 744725 DOI: 10.1097/00004032-197811000-00002  0.361
1978 Kennedy AR, Little JB. Protease inhibitors suppress radiation-induced malignant transformation in vitro. Nature. 276: 825-826. PMID 723956 DOI: 10.1038/276825A0  0.391
1978 Weichselbaum RR, Nove J, Little JB. Deficient recovery from potentially lethal radiation damage in ataxia telangiectasia and xeroderma pigmentosum Nature. 271: 261-262. PMID 622166 DOI: 10.1038/271261A0  0.422
1978 Kennedy AR, McGandy RB, Little JB. Histochemical, light and electron microscopic study of polonium-210 induced peripheral tumors in hamster lungs: evidence implicating the Clara cell as the cell of origin. European Journal of Cancer. 13: 1325-40. PMID 590290 DOI: 10.1016/0014-2964(77)90043-3  0.324
1978 Weichselbaum RR, Nove J, Little JB. X-ray sensitivity of diploid fibroblasts from patients with hereditary or sporadic retinoblastoma. Proceedings of the National Academy of Sciences of the United States of America. 75: 3962-4. PMID 279012 DOI: 10.1073/Pnas.75.8.3962  0.353
1978 Robertson JB, Williams JR, Little JB. Enhancement of radiation killing of cultured mammalian cells by cordycepin. International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine. 34: 417-29. PMID 224001 DOI: 10.1080/09553007814551081  0.4
1978 Zamansky GB, Little JB, Black PH, Kaplan JC. Inhibition of postreplication repair and the enhancement of induction of SV40 virus from transformed hamster kidney cells. Mutation Research. 51: 109-19. PMID 209322 DOI: 10.1016/0027-5107(78)90013-1  0.359
1978 Chan GL, Little JB. Induction of ouabain-resistant mutations in C3H 10T1/2 mouse cells by ultraviolet light. Proceedings of the National Academy of Sciences of the United States of America. 75: 3363-6. PMID 150601 DOI: 10.1073/Pnas.75.7.3363  0.319
1978 Kennedy AR, McGandy RB, Little JB. Morphologic and histochemical characteristics of cell lines derived from hamster peripheral lung tumors. European Journal of Cancer. 13: 1341-50. PMID 145368 DOI: 10.1016/0014-2964(77)90044-5  0.336
1978 Williams JR, Gould RG, Flynn D, Robertson JB, Little JB. Relative Survival of Hybrid X-Ray-Resistant, and Normally Sensitive Mammalian Cells Exposed to X Rays and Protons under Aerobic and Hypoxic Conditions Radiation Research. 73: 585. DOI: 10.2307/3574960  0.378
1978 Little JB. Biological Consequences Of X-Ray Induced Dna Damage And Repair Processes In Relation To Cell Killing And Carcinogenesis Dna Repair Mechanisms. 701-711. DOI: 10.1016/B978-0-12-322650-1.50137-5  0.381
1978 Little JB, Weichselbaum RR, Nove J, Albert DM. X-Ray Sensitivity Of Fibroblasts From Patients With Retinoblastoma And With Abnormalities Of Chromosome 13 Dna Repair Mechanisms. 685-690. DOI: 10.1016/B978-0-12-322650-1.50134-X  0.31
1978 Zamansky GB, Little JB, Black PH, Kaplan JC. The Effect Of Dna Damage On The Induction Of Simian Virus 40 (Sv40) In Transformed Hamster Cells Dna Repair Mechanisms. 567-571. DOI: 10.1016/B978-0-12-322650-1.50114-4  0.346
1978 Selsky C, Weichselbaum R, Little JB. Defective Host-Cell Reactivation Of Uv-Irradiated Herpes Simplex Virus By Bloom'S Syndrome Skin Fibroblasts Dna Repair Mechanisms. 555-558. DOI: 10.1016/B978-0-12-322650-1.50111-9  0.325
1977 Weichselbaum R, Epstein J, Little JB. A technique for developing established cell lines from human osteosarcomas. In Vitro. 12: 833-6. PMID 1071745 DOI: 10.1007/Bf02796368  0.359
1977 Weichselbaum RR, Epstein J, Little JB, Kornblith P. Inherent cellular radiosensitivity of human tumors of varying clinical curability. Ajr. American Journal of Roentgenology. 127: 1027-32. PMID 1069484 DOI: 10.2214/Ajr.127.6.1027  0.398
1977 Fornace AJ, Little JB. DNA crosslinking induced by x-rays and chemical agents. Biochimica Et Biophysica Acta. 477: 343-55. PMID 889829 DOI: 10.1016/0005-2787(77)90253-2  0.546
1977 Weichselbaum RR, Nove J, Little JB. Skin fibroblasts from a D-deletion type retinoblastoma patient are abnormally X-ray sensitive Nature. 266: 726-727. PMID 876352 DOI: 10.1038/266726A0  0.323
1977 Weichselbaum RR, Liszczak TM, Phillips JP, Little JB, Epstein J, Kornblith PL. Characterization and radiobiologic parameters of medulloblastoma in vitro. Cancer. 40: 1087-96. PMID 561648 DOI: 10.1002/1097-0142(197709)40:3<1087::Aid-Cncr2820400317>3.0.Co;2-N  0.307
1977 Robertson JB, Williams JR, Little JB. Relative responses of an X-ray-resistant hybrid cell-line and its parent line to X-irradiation, ultraviolet light, actinomycin D and cordycepin. International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine. 31: 529-39. PMID 301863 DOI: 10.1080/09553007714550641  0.384
1977 Weichselbaum R, Little JB, Nove J. Response of human osteosarcoma in vitro to irradiation: evidence for unusual cellular repair activity. International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine. 31: 295-9. PMID 300732 DOI: 10.1080/09553007714550351  0.334
1977 Robertson JB, Oleson FB, Williams JR, Little JB. Survival of synchronized V79 cells treated with X-rays and cordycepin. International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine. 31: 11-6. PMID 300368 DOI: 10.1080/09553007714550021  0.373
1977 Laval F, Little JB. Enhancement of Survival of X-Irradiated Mammalian Cells by the Uncoupler of Oxidative Phosphorylation, m-Chloro Carbonyl Cyanide Phenylhydrazone Radiation Research. 71: 571. DOI: 10.2307/3574625  0.413
1977 Williams JR, Little JB. Selective Protection of Cultured Human Cells from the Toxic Effects of Ultraviolet Light by Proflavine Pretreatment Radiation Research. 72: 154. DOI: 10.2307/3574565  0.354
1976 Brown WT, Epstein J, Little JB. Progeria cells are stimulated to repair DNA by co-cultivation with normal cells. Experimental Cell Research. 97: 291-6. PMID 1248520 DOI: 10.1016/0014-4827(76)90619-4  0.412
1976 Terzaghi M, Little JB. Establishment and characteristics of a hamster lung adenocarcinoma in vivo and in vitro. Journal of the National Cancer Institute. 55: 865-72. PMID 1185808 DOI: 10.1093/Jnci/55.4.865  0.349
1976 Little JB. Relationship between DNA repair capacity and cellular aging. Gerontology. 22: 28-55. PMID 1107150 DOI: 10.1159/000212123  0.328
1976 Terzaghi M, Little JB. Letter: Oncogenic transformation in vitro after split-dose x-irradiation. International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine. 29: 583-7. PMID 1085765 DOI: 10.1080/09553007614550691  0.339
1976 Lampidis TJ, Weichselbaum RR, Little JB. Letter: Gamma-irradiation of mammalian beating heart cells in vitro. Effects on cellular function. International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine. 28: 99-102. PMID 1081094 DOI: 10.1080/09553007514550801  0.325
1976 Chan GL, Little JB. Induction of oncogenic transformation in vitro by ultraviolet light. Nature. 264: 442-444. PMID 1004574 DOI: 10.1038/264442A0  0.368
1976 Weichselbaum RR, Epstein J, Little JB. In vitro radiosensitivity of human dipliod fibroblasts derived from patients with unusual clinical responses to radiation. Radiology. 121: 479-82. PMID 981631 DOI: 10.1148/121.2.479  0.371
1976 Zamansky GB, Kleinman LF, Little JB, Black PH, Kaplan JC. The effect of caffeine on the ultraviolet light induction of SV40 virus from transformed hamster cells. Virology. 73: 468-75. PMID 183364 DOI: 10.1016/0042-6822(76)90408-6  0.358
1976 Weichselbaum RR, Epstein J, Little JB, Kornblith PL. In vitro cellular radiosensitivity of human malignant tumors. European Journal of Cancer. 12: 47-51. PMID 178509 DOI: 10.1016/0014-2964(76)90123-7  0.347
1976 Little JB, Epstein J, Williams JR. Repair of DNA strand breaks in progeric fibroblasts and aging human diploid cells. Basic Life Sciences. 793-800. PMID 172062 DOI: 10.1007/978-1-4684-2898-8_58  0.417
1976 Little JB, Williams JR. Enhancement of Survival of Irradiated Plateau Phase Cells by Dinitrophenol: Effect of Dose-Rate and Cell Strain Radiation Research. 66: 90. DOI: 10.2307/3574358  0.428
1975 Terzaghi M, Little JB. Repair of potentially lethal radiation damage in mammalian cells is associated with enhancement of malignant transformation. Nature. 253: 548-549. PMID 1167940 DOI: 10.1038/253548A0  0.406
1975 Little JB, Kennedy AR, McGandy RB. Lung cancer induced in hamsters by low doses of alpha radiation from polonium-210. Science (New York, N.Y.). 188: 737-8. PMID 1124396 DOI: 10.1126/Science.1124396  0.302
1975 Robertson JB, Williams JR, Schmidt RA, Little JB, Flynn DF, Suit HD. Radiobiological studies of a high-energy modulated proton beam utilizing cultured mammalian cells. Cancer. 35: 1664-77. PMID 807318 DOI: 10.1002/1097-0142(197506)35:6<1664::Aid-Cncr2820350628>3.0.Co;2-#  0.35
1974 Williams JR, Little JB, Shipley WU. Association of mammalian cell death with a specific endonucleolytic degradation of DNA Nature. 252: 754-755. PMID 4474604 DOI: 10.1038/252754A0  0.364
1974 Epstein J, Williams JR, Little JB. Rate of DNA repair in progeric and normal human fibroblasts. Biochemical and Biophysical Research Communications. 59: 850-7. PMID 4415479 DOI: 10.1016/S0006-291X(74)80057-4  0.387
1973 Zininger GF, Little JB. Fractionated radiation response of human cells in stationary and exponential phases of growth. Radiology. 108: 423-8. PMID 4719049 DOI: 10.1148/108.2.423  0.434
1973 Little JB, Hahn GM, Frindel E, Tubiana M. Repair of potentially lethal radiation damage in vitro and in vivo. Radiology. 106: 689-94. PMID 4684814 DOI: 10.1148/106.3.689  0.368
1973 Little JB, Hahn GM. Life-cycle dependence of repair of potentially-lethal radiation damage. International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine. 23: 401-7. PMID 4540850 DOI: 10.1080/09553007314550451  0.333
1973 Epstein J, Williams JR, Little JB. Deficient DNA repair in human progeroid cells. Proceedings of the National Academy of Sciences of the United States of America. 70: 977-81. PMID 4515628 DOI: 10.1073/Pnas.70.4.977  0.429
1973 Little JB. Factors Influencing the Repair of Potentially Lethal Radiation Damage in Growth-Inhibited Human Cells Radiation Research. 56: 320. DOI: 10.2307/3573669  0.394
1972 Randtke AS, Williams JR, Little JB. Selection of mutant human cells whose progression into DNA synthesis is sensitive to UV irradiation. Experimental Cell Research. 70: 360-4. PMID 5058912 DOI: 10.1016/0014-4827(72)90147-4  0.412
1971 Little JB. Factors influencing exogenous nucleoside utilization in DNA synthesis by irradiated human cells. Experimental Cell Research. 62: 368-74. PMID 5495453 DOI: 10.1016/0014-4827(70)90567-7  0.374
1971 Little JB. Repair of potentially-lethal radiation damage in mammalian cells: enhancement by conditioned medium from stationary cultures. International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine. 20: 87-92. PMID 5315187 DOI: 10.1080/09553007114550921  0.387
1970 Davis MA, Little JB, Ayyangar KMMS, Reddy AR. Relative Biological Effectiveness of the 10 B(n, α) 7 Li Reaction in HeLa Cells Radiation Research. 43: 534. DOI: 10.2307/3573228  0.342
1970 Little JB. Irradiation of Primary Human Amnion Cell Cultures: Effects on DNA Synthesis and Progression through the Cell Cycle Radiation Research. 44: 674. DOI: 10.2307/3573149  0.41
1969 Little JB. Differential response of rapidly and slowly proliferating human cells to X irradiation. Radiology. 93: 307-13. PMID 5822704 DOI: 10.1148/93.2.307  0.423
1969 Radford EP, Hunt VR, Little JB, Wynder EL, Hoffmann D. Carcinogenicity of tobacco-smoke constituents Science. 165: 312-313. PMID 5787992 DOI: 10.1126/Science.165.3890.312  0.605
1969 Little JB. Repair of Sub-lethal and Potentially Lethal Radiation Damage in Plateau Phase Cultures of Human Cells Nature. 224: 804-806. PMID 5361657 DOI: 10.1038/224804A0  0.435
1969 Little JB. Effect of Diagnostic Radiation Upon the Human Foetus: Follow-up Study of 152 Children Exposed to Irradiation During the First 4 Months of Foetal Life Due to X-Ray Examination of the Maternal AbdomenEffect of Diagnostic Radiation Upon the Human Foetus: Follow-up Study of 152 Children Exposed to Irradiation During the First 4 Months of Foetal Life Due to X-Ray Examination of the Maternal Abdomen. ByNøkkentvedKirsten. 40 Danish kroner. Pp. 222, with 105 tables. Munksgaard, Copenhagen, 1968. Radiology. 92: 1138-1139. DOI: 10.1148/92.5.1138B  0.326
1968 Vierling AF, Radford EP, Little JB. Circulating antidiuretic hormone in the X-irradiated rat. Radiation Research. 36: 441-453. PMID 17387877 DOI: 10.2307/3572579  0.618
1968 Little JB. Delayed initiation of DNA synthesis in irradiated human diploid cells. Nature. 218: 1064-1065. PMID 5656624 DOI: 10.1038/2181064A0  0.432
1968 Little JB. Radiation-induced DNA degradation in human cells: lack of evidence following moderate doses of x-rays. International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine. 13: 591-5. PMID 5301988 DOI: 10.1080/09553006814550671  0.427
1968 Little JB. Cellular effects of ionizing radiation. The New England Journal of Medicine. 278: 369-76 concl. PMID 4865594 DOI: 10.1056/Nejm196802152780705  0.367
1967 Vierling AF, Little JB, Radford EP. Antidiuretic hormone bio-assay in rats with hereditary hypothalamic diabetes insipidus (Brattleboro strain). Endocrinology. 80: 211-214. PMID 6029399 DOI: 10.1210/Endo-80-1-211  0.581
1967 Little JB, Radford EP. Polonium-210 in bronchial epithelium of cigarette smokers. Science (New York, N.Y.). 155: 606-7. PMID 6015882 DOI: 10.1126/Science.155.3762.606  0.62
1967 Little JB. Environmental Hazards???Ionizing Radiation Journal of Occupational and Environmental Medicine. 9: 532-533. DOI: 10.1097/00043764-196710000-00034  0.316
1967 Little JB. ENVIRONMENTAL HAZARDS. IONIZING RADIATION Obstetrical & Gynecological Survey. 22: 280-283. DOI: 10.1097/00006254-196704000-00027  0.316
1967 Little JB, Radford EP. Polonium-210 in bronchial epithelium of cigarette smokers Science. 155: 606.  0.533
1966 Little JB, Klevay LM, Radford EP, McGandy RB. Antidiuretic hormone inactivation by isolated perfused rat liver. The American Journal of Physiology. 211: 786-792. PMID 5927910 DOI: 10.1152/Ajplegacy.1966.211.3.786  0.567
1966 Little JB. Environmental hazards. Ionizing radiation. The New England Journal of Medicine. 275: 929-37. PMID 5331127 DOI: 10.1056/Nejm196610272751705  0.316
1965 Little JB, Radford EP, McCombs HL, Hunt VR. Distribution of polonium-210 in pulmonary tissues of cigarette smokers. New England Journal of Medicine. 273: 1343-1351. PMID 5848113 DOI: 10.1056/Nejm196512162732501  0.597
1964 LITTLE JB, RADFORD EP. CIRCULATING ANTIDIURETIC HORMONE IN RATS: EFFECTS OF DIETARY The American Journal of Physiology. 207: 821-825. PMID 14222425 DOI: 10.1152/Ajplegacy.1964.207.4.821  0.574
1964 LITTLE JB, RADFORD EP. EFFECTS OF IONIZING RADIATION AND THEIR IMPORTANCE IN ANESTHESIOLOGY. Anesthesiology. 25: 479-489. PMID 14192795 DOI: 10.1097/00000542-196407000-00011  0.628
1964 LITTLE JB, RADFORD EP. BIO-ASSAY FOR ANTIDIURETIC ACTIVITY IN BLOOD OF UNDISTURBED RATS. Journal of Applied Physiology. 19: 179-186. PMID 14155277 DOI: 10.1152/Jappl.1964.19.2.179  0.585
1964 Radford EP, Hunt VR, Little JB. Polonium-210 in cigarette smokers Science. 146: 87. DOI: 10.1126/Science.146.3640.86  0.568
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