Sarah C. Lummis - Publications

Affiliations: 
Biochemistry University of Cambridge, Cambridge, England, United Kingdom 

66 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Rienzo M, Rocchi AR, Threatt SD, Dougherty DA, Lummis SC. Perturbation of Critical Prolines in Gloeobacter violaceus Ligand-Gated Ion Channel (GLIC) Supports Conserved Gating Motions Among Cys-Loop Receptors. The Journal of Biological Chemistry. PMID 26668320 DOI: 10.1074/jbc.M115.694372  0.52
2015 Price KL, Lillestol RK, Ulens C, Lummis SC. Varenicline Interactions at the 5-HT3 Receptor Ligand Binding Site are Revealed by 5-HTBP. Acs Chemical Neuroscience. 6: 1151-7. PMID 25648658 DOI: 10.1021/cn500369h  0.52
2015 Schaefer N, Kluck CJ, Price KL, Meiselbach H, Vornberger N, Schwarzinger S, Hartmann S, Langlhofer G, Schulz S, Schlegel N, Brockmann K, Lynch B, Becker CM, Lummis SC, Villmann C. Disturbed neuronal ER-Golgi sorting of unassembled glycine receptors suggests altered subcellular processing is a cause of human hyperekplexia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 422-37. PMID 25568133 DOI: 10.1523/JNEUROSCI.1509-14.2015  0.52
2014 Rienzo M, Lummis SC, Dougherty DA. Structural requirements in the transmembrane domain of GLIC revealed by incorporation of noncanonical histidine analogs. Chemistry & Biology. 21: 1700-6. PMID 25525989 DOI: 10.1016/j.chembiol.2014.10.019  0.52
2014 Price KL, Lummis SC. An atypical residue in the pore of Varroa destructor GABA-activated RDL receptors affects picrotoxin block and thymol modulation. Insect Biochemistry and Molecular Biology. 55: 19-25. PMID 25460510 DOI: 10.1016/j.ibmb.2014.10.002  0.52
2014 Thompson AJ, Alqazzaz M, Price KL, Weston DA, Lummis SC. Phenylalanine in the pore of the Erwinia ligand-gated ion channel modulates picrotoxinin potency but not receptor function. Biochemistry. 53: 6183-8. PMID 25238029 DOI: 10.1021/bi5008035  0.52
2014 Ulens C, Spurny R, Thompson AJ, Alqazzaz M, Debaveye S, Han L, Price K, Villalgordo JM, Tresadern G, Lynch JW, Lummis SC. The prokaryote ligand-gated ion channel ELIC captured in a pore blocker-bound conformation by the Alzheimer's disease drug memantine. Structure (London, England : 1993). 22: 1399-407. PMID 25199693 DOI: 10.1016/j.str.2014.07.013  0.52
2014 Thompson AJ, Verheij MH, Verbeek J, Windhorst AD, de Esch IJ, Lummis SC. The binding characteristics and orientation of a novel radioligand with distinct properties at 5-HT3A and 5-HT3AB receptors. Neuropharmacology. 86: 378-88. PMID 25174552 DOI: 10.1016/j.neuropharm.2014.08.008  0.52
2014 Comitani F, Cohen N, Ashby J, Botten D, Lummis SC, Molteni C. Insights into the binding of GABA to the insect RDL receptor from atomistic simulations: a comparison of models. Journal of Computer-Aided Molecular Design. 28: 35-48. PMID 24442887 DOI: 10.1007/s10822-013-9704-0  0.52
2014 Kessler A, Sahin-Nadeem H, Lummis SC, Weigel I, Pischetsrieder M, Buettner A, Villmann C. GABA(A) receptor modulation by terpenoids from Sideritis extracts. Molecular Nutrition & Food Research. 58: 851-62. PMID 24273211 DOI: 10.1002/mnfr.201300420  0.52
2013 Del Cadia M, De Rienzo F, Weston DA, Thompson AJ, Menziani MC, Lummis SC. Exploring a potential palonosetron allosteric binding site in the 5-HT(3) receptor. Bioorganic & Medicinal Chemistry. 21: 7523-8. PMID 24128813 DOI: 10.1016/j.bmc.2013.09.028  0.52
2013 Thompson AJ, Verheij MH, van Muijlwijk-Koezen JE, Lummis SC, Leurs R, de Esch IJ. Structure-activity relationships of quinoxaline-based 5-HT3A and 5-HT3AB receptor-selective ligands. Chemmedchem. 8: 946-55. PMID 23640722 DOI: 10.1002/cmdc.201300032  0.52
2013 Spurny R, Billen B, Howard RJ, Brams M, Debaveye S, Price KL, Weston DA, Strelkov SV, Tytgat J, Bertrand S, Bertrand D, Lummis SC, Ulens C. Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia chrysanthemi ligand-gated ion channel (ELIC). The Journal of Biological Chemistry. 288: 8355-64. PMID 23364792 DOI: 10.1074/jbc.M112.424507  0.52
2012 Ashby JA, McGonigle IV, Price KL, Cohen N, Comitani F, Dougherty DA, Molteni C, Lummis SC. GABA binding to an insect GABA receptor: a molecular dynamics and mutagenesis study. Biophysical Journal. 103: 2071-81. PMID 23200041 DOI: 10.1016/j.bpj.2012.10.016  0.52
2012 Spurny R, Ramerstorfer J, Price K, Brams M, Ernst M, Nury H, Verheij M, Legrand P, Bertrand D, Bertrand S, Dougherty DA, de Esch IJ, Corringer PJ, Sieghart W, Lummis SC, et al. Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines. Proceedings of the National Academy of Sciences of the United States of America. 109: E3028-34. PMID 23035248 DOI: 10.1073/pnas.1208208109  0.52
2012 Verheij MH, Thompson AJ, van Muijlwijk-Koezen JE, Lummis SC, Leurs R, de Esch IJ. Design, synthesis, and structure-activity relationships of highly potent 5-HT₃ receptor ligands. Journal of Medicinal Chemistry. 55: 8603-14. PMID 23006041 DOI: 10.1021/jm300801u  0.52
2012 Akdemir A, Edink E, Thompson AJ, Lummis SC, Kooistra AJ, de Graaf C, de Esch IJ. Identification of novel α7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric α7 receptor ligand binding domain. Bioorganic & Medicinal Chemistry. 20: 5992-6002. PMID 22959526 DOI: 10.1016/j.bmc.2012.06.054  0.52
2012 Huang SH, Lewis TM, Lummis SC, Thompson AJ, Chebib M, Johnston GA, Duke RK. Mixed antagonistic effects of the ginkgolides at recombinant human ρ1 GABAC receptors. Neuropharmacology. 63: 1127-39. PMID 22828636 DOI: 10.1016/j.neuropharm.2012.06.067  0.52
2012 Utkin YN, Weise C, Kasheverov IE, Andreeva TV, Kryukova EV, Zhmak MN, Starkov VG, Hoang NA, Bertrand D, Ramerstorfer J, Sieghart W, Thompson AJ, Lummis SC, Tsetlin VI. Azemiopsin from Azemiops feae viper venom, a novel polypeptide ligand of nicotinic acetylcholine receptor. The Journal of Biological Chemistry. 287: 27079-86. PMID 22613724 DOI: 10.1074/jbc.M112.363051  0.52
2012 Lummis SC, Harrison NJ, Wang J, Ashby JA, Millen KS, Beene DL, Dougherty DA. Multiple Tyrosine Residues Contribute to GABA Binding in the GABA(C) Receptor Binding Pocket. Acs Chemical Neuroscience. 3: 186-192. PMID 22448304 DOI: 10.1021/cn200103n  0.52
2012 Simonin J, Vernekar SK, Thompson AJ, Hothersall JD, Connolly CN, Lummis SC, Lochner M. High-affinity fluorescent ligands for the 5-HT(3) receptor. Bioorganic & Medicinal Chemistry Letters. 22: 1151-5. PMID 22189135 DOI: 10.1016/j.bmcl.2011.11.097  0.52
2011 Alqazzaz M, Thompson AJ, Price KL, Breitinger HG, Lummis SC. Cys-loop receptor channel blockers also block GLIC. Biophysical Journal. 101: 2912-8. PMID 22208189 DOI: 10.1016/j.bpj.2011.10.055  0.52
2011 Lummis SC, McGonigle I, Ashby JA, Dougherty DA. Two amino acid residues contribute to a cation-Ï€ binding interaction in the binding site of an insect GABA receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 12371-6. PMID 21865479 DOI: 10.1523/JNEUROSCI.1610-11.2011  0.52
2011 Verheij MH, de Graaf C, de Kloe GE, Nijmeijer S, Vischer HF, Smits RA, Zuiderveld OP, Hulscher S, Silvestri L, Thompson AJ, van Muijlwijk-Koezen JE, Lummis SC, Leurs R, de Esch IJ. Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine Hâ‚„ and the ion channel serotonin 5-HT₃A. Bioorganic & Medicinal Chemistry Letters. 21: 5460-4. PMID 21782429 DOI: 10.1016/j.bmcl.2011.06.123  0.52
2011 Lummis SC, Thompson AJ, Bencherif M, Lester HA. Varenicline is a potent agonist of the human 5-hydroxytryptamine3 receptor. The Journal of Pharmacology and Experimental Therapeutics. 339: 125-31. PMID 21775477 DOI: 10.1124/jpet.111.185306  0.52
2011 Wheeler DW, Thompson AJ, Corletto F, Reckless J, Loke JC, Lapaque N, Grant AJ, Mastroeni P, Grainger DJ, Padgett CL, O'Brien JA, Miller NG, Trowsdale J, Lummis SC, Menon DK, et al. Anaesthetic impairment of immune function is mediated via GABA(A) receptors. Plos One. 6: e17152. PMID 21390329 DOI: 10.1371/journal.pone.0017152  0.52
2011 Pless SA, Hanek AP, Price KL, Lynch JW, Lester HA, Dougherty DA, Lummis SC. A cation-π interaction at a phenylalanine residue in the glycine receptor binding site is conserved for different agonists. Molecular Pharmacology. 79: 742-8. PMID 21266487 DOI: 10.1124/mol.110.069583  0.52
2010 Quek GX, Lin D, Halliday JI, Absalom N, Ambrus JI, Thompson AJ, Lochner M, Lummis SC, McLeod MD, Chebib M. Identifying the binding site of novel methyllycaconitine (MLA) analogs at α4β2 nicotinic acetylcholine receptors. Acs Chemical Neuroscience. 1: 796-809. PMID 22778816 DOI: 10.1021/cn100073x  0.52
2010 Thompson AJ, Verheij MH, Leurs R, De Esch IJ, Lummis SC. An efficient and information-rich biochemical method design for fragment library screening on ion channels. Biotechniques. 49: 822-9. PMID 21091447 DOI: 10.2144/000113538  0.52
2010 Thompson AJ, Lester HA, Lummis SC. The structural basis of function in Cys-loop receptors. Quarterly Reviews of Biophysics. 43: 449-99. PMID 20849671 DOI: 10.1017/S0033583510000168  0.52
2010 Vernekar SK, Hallaq HY, Clarkson G, Thompson AJ, Silvestri L, Lummis SC, Lochner M. Toward biophysical probes for the 5-HT3 receptor: structure-activity relationship study of granisetron derivatives. Journal of Medicinal Chemistry. 53: 2324-8. PMID 20146481 DOI: 10.1021/jm901827x  0.52
2009 Bartos M, Price KL, Lummis SC, Bouzat C. Glutamine 57 at the complementary binding site face is a key determinant of morantel selectivity for {alpha}7 nicotinic receptors. The Journal of Biological Chemistry. 284: 21478-87. PMID 19506073 DOI: 10.1074/jbc.M109.013797  0.52
2008 Pless SA, Millen KS, Hanek AP, Lynch JW, Lester HA, Lummis SC, Dougherty DA. A cation-pi interaction in the binding site of the glycine receptor is mediated by a phenylalanine residue. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 10937-42. PMID 18945901 DOI: 10.1523/JNEUROSCI.2540-08.2008  0.52
2008 Price KL, Bower KS, Thompson AJ, Lester HA, Dougherty DA, Lummis SC. A hydrogen bond in loop A is critical for the binding and function of the 5-HT3 receptor. Biochemistry. 47: 6370-7. PMID 18498149 DOI: 10.1021/bi800222n  0.52
2008 Bower KS, Price KL, Sturdee LE, Dayrell M, Dougherty DA, Lummis SC. 5-Fluorotryptamine is a partial agonist at 5-HT3 receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function. European Journal of Pharmacology. 580: 291-7. PMID 18082160 DOI: 10.1016/j.ejphar.2007.11.014  0.52
2007 Price KL, Millen KS, Lummis SC. Transducing agonist binding to channel gating involves different interactions in 5-HT3 and GABAC receptors. The Journal of Biological Chemistry. 282: 25623-30. PMID 17606617 DOI: 10.1074/jbc.M702524200  0.52
2007 Padgett CL, Hanek AP, Lester HA, Dougherty DA, Lummis SC. Unnatural amino acid mutagenesis of the GABA(A) receptor binding site residues reveals a novel cation-pi interaction between GABA and beta 2Tyr97. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 886-92. PMID 17251430 DOI: 10.1523/JNEUROSCI.4791-06.2007  0.52
2006 Thompson AJ, Sullivan NL, Lummis SC. Characterization of 5-HT3 receptor mutations identified in schizophrenic patients. Journal of Molecular Neuroscience : Mn. 30: 273-81. PMID 17401153 DOI: 10.1385/JMN:30:3:273  0.52
2006 Sullivan NL, Thompson AJ, Price KL, Lummis SC. Defining the roles of Asn-128, Glu-129 and Phe-130 in loop A of the 5-HT3 receptor. Molecular Membrane Biology. 23: 442-51. PMID 17060161 DOI: 10.1080/09687860600831539  0.52
2006 Reeves DC, Lummis SC. Detection of human and rodent 5-HT3B receptor subunits by anti-peptide polyclonal antibodies. Bmc Neuroscience. 7: 27. PMID 16571125 DOI: 10.1186/1471-2202-7-27  0.52
2005 Lummis SC, Beene DL, Lee LW, Lester HA, Broadhurst RW, Dougherty DA. Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel. Nature. 438: 248-52. PMID 16281040 DOI: 10.1038/nature04130  0.52
2005 Lummis SC, L Beene D, Harrison NJ, Lester HA, Dougherty DA. A cation-pi binding interaction with a tyrosine in the binding site of the GABAC receptor. Chemistry & Biology. 12: 993-7. PMID 16183023 DOI: 10.1016/j.chembiol.2005.06.012  0.52
2005 Thompson AJ, Price KL, Reeves DC, Chan SL, Chau PL, Lummis SC. Locating an antagonist in the 5-HT3 receptor binding site using modeling and radioligand binding. The Journal of Biological Chemistry. 280: 20476-82. PMID 15781467 DOI: 10.1074/jbc.M413610200  0.52
2004 Beene DL, Price KL, Lester HA, Dougherty DA, Lummis SC. Tyrosine residues that control binding and gating in the 5-hydroxytryptamine3 receptor revealed by unnatural amino acid mutagenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 9097-104. PMID 15483128 DOI: 10.1523/JNEUROSCI.2429-04.2004  0.52
2003 Reeves DC, Sayed MF, Chau PL, Price KL, Lummis SC. Prediction of 5-HT3 receptor agonist-binding residues using homology modeling. Biophysical Journal. 84: 2338-44. PMID 12668442 DOI: 10.1016/S0006-3495(03)75039-5  0.52
2002 Reeves DC, Lummis SC. The molecular basis of the structure and function of the 5-HT3 receptor: a model ligand-gated ion channel (review). Molecular Membrane Biology. 19: 11-26. PMID 11989819 DOI: 10.1080/09687680110110048  0.52
2002 Greenfield LJ, Zaman SH, Sutherland ML, Lummis SC, Niemeyer MI, Barnard EA, Macdonald RL. Mutation of the GABAA receptor M1 transmembrane proline increases GABA affinity and reduces barbiturate enhancement. Neuropharmacology. 42: 502-21. PMID 11955521 DOI: 10.1016/S0028-3908(01)00196-4  0.52
2001 Reeves DC, Goren EN, Akabas MH, Lummis SC. Structural and electrostatic properties of the 5-HT3 receptor pore revealed by substituted cysteine accessibility mutagenesis. The Journal of Biological Chemistry. 276: 42035-42. PMID 11557761 DOI: 10.1074/jbc.M106066200  0.52
2001 Gunthorpe MJ, Lummis SC. Conversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily. The Journal of Biological Chemistry. 276: 10977-83. PMID 11439930  0.52
2000 Nayak SV, Rondé P, Spier AD, Lummis SC, Nichols RA. Nicotinic receptors co-localize with 5-HT(3) serotonin receptors on striatal nerve terminals. Neuropharmacology. 39: 2681-90. PMID 11044738 DOI: 10.1016/S0028-3908(00)00109-X  0.52
1995 Buckingham SD, Balk ML, Lummis SC, Jewess P, Sattelle DB. Actions of nitromethylenes on an alpha-bungarotoxin-sensitive neuronal nicotinic acetylcholine receptor. Neuropharmacology. 34: 591-7. PMID 7566494 DOI: 10.1016/0028-3908(95)00024-Z  0.52
1993 Buckingham SD, Lummis SC, Balk ML, Schroeder M, Sattelle DB. Actions of vesamicol on an alpha-bungarotoxin-sensitive neuronal nicotinic acetylcholine receptor. The Journal of Experimental Biology. 182: 255-64. PMID 8228781  0.52
1992 Lummis SC, Buckingham SD, Balk ML, Holyoke CW, Sattelle DB. Actions of a series of bisquaternary compounds on nicotinic acetylcholine receptors in insects: ligand binding and electrophysiological studies. Neuropharmacology. 31: 379-82. PMID 1522955 DOI: 10.1016/0028-3908(92)90070-6  0.52
1991 Sattelle DB, Lummis SC, Wong JF, Rauh JJ. Pharmacology of insect GABA receptors. Neurochemical Research. 16: 363-74. PMID 1664063 DOI: 10.1007/BF00966100  0.52
1990 Rauh JJ, Lummis SC, Sattelle DB. Pharmacological and biochemical properties of insect GABA receptors. Trends in Pharmacological Sciences. 11: 325-9. PMID 2168103  0.4
1990 Lummis SC, Buckingham SD, Rauh JJ, Sattelle DB. Blocking actions of heptachlor at an insect central nervous system GABA receptor. Proceedings of the Royal Society of London. Series B, Biological Sciences. 240: 97-106. PMID 1694587 DOI: 10.1098/rspb.1990.0029  0.52
1989 Lummis SC, Sattelle DB. Insect nervous system [(3)H]saxitoxin binding sites: characterization and target size. Neurochemistry International. 15: 391-5. PMID 20504511  0.4
1989 Wafford KA, Lummis SC, Sattelle DB. Block of an insect central nervous system GABA receptor by cyclodiene and cyclohexane insecticides. Proceedings of the Royal Society of London. Series B, Biological Sciences. 237: 53-61. PMID 2474166  0.52
1988 Lummis SC, Ellory JC, Sattelle DB. The cross-linking reagent dimethyl suberimate modifies the target size of an insect nervous system nicotinic acetylcholine receptor. Neuroscience Letters. 87: 145-50. PMID 3380333  0.4
1988 Pinnock RD, Lummis SC, Chiappinelli VA, Sattelle DB. Kappa-bungarotoxin blocks an alpha-bungarotoxin-sensitive nicotinic receptor in the insect central nervous system. Brain Research. 458: 45-52. PMID 3208100 DOI: 10.1016/0006-8993(88)90494-5  0.52
1986 Lummis SC, Sattelle DB. Binding sites for [(3)H]GABA, [(3)H]flunitrazepam and [(35)S]TBPS in insect CNS. Neurochemistry International. 9: 287-93. PMID 20493128  0.4
1985 Lummis SC, Sattelle DB. Insect central nervous system gamma-aminobutyric acid. Neuroscience Letters. 60: 13-8. PMID 2997671  0.4
1985 Lummis SC, Sattelle DB. Binding of N-[propionyl-3H]propionylated alpha-bungarotoxin and L-[benzilic-4,4'-3H] quinuclidinyl benzilate to CNS extracts of the cockroach Periplaneta americana. Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology. 80: 75-83. PMID 2858352  0.4
1984 Lummis SC, Sattelle DB, Ellory JC. Molecular weight estimates of insect cholinergic receptors by radiation inactivation. Neuroscience Letters. 44: 7-12. PMID 6717855  0.4
1981 Krogsgaard-Larsen P, Snowman A, Lummis SC, Olsen RW. Characterization of the binding of the GABA agonist [3H]piperidine-4-sulphonic acid to bovine brain synaptic membranes Journal of Neurochemistry. 37: 401-409. PMID 6267201  0.52
1981 Olsen RW, Bergman MO, Van Ness PC, Lummis SC, Watkins AE, Napias C, Greenlee DV. gamma-Aminobutyric acid receptor binding in mammalian brain. Heterogeneity of binding sites. Molecular Pharmacology. 19: 217-27. PMID 6262615  0.52
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