Sarah C. Lummis - Related publications

Affiliations: 
Biochemistry University of Cambridge, Cambridge, England, United Kingdom 
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Falk-Petersen CB, Tsonkov TM, Nielsen MS, Harpsøe K, Bundgaard C, Frølund B, Kristiansen U, Gloriam DE, Wellendorph P. Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABA receptors. Scientific Reports. 10: 10078. PMID 32572053 DOI: 10.1038/s41598-020-66821-0   
2020 Park J, Fu Z, Frangaj A, Liu J, Mosyak L, Shen T, Slavkovich VN, Ray KM, Taura J, Cao B, Geng Y, Zuo H, Kou Y, Grassucci R, Chen S, et al. Structure of human GABA receptor in an inactive state. Nature. PMID 32581365 DOI: 10.1038/s41586-020-2452-0   
2020 Akk G, Germann AL, Sugasawa Y, Pierce SR, Evers AS, Steinbach JH. Enhancement of muscimol binding and gating by allosteric modulators of the GABA receptor: relating occupancy to state functions. Molecular Pharmacology. PMID 32723768 DOI: 10.1124/molpharm.120.000066   
2020 Papasergi-Scott MM, Robertson MJ, Seven AB, Panova O, Mathiesen JM, Skiniotis G. Structures of metabotropic GABA receptor. Nature. PMID 32580208 DOI: 10.1038/s41586-020-2469-4   
2020 Germann AL, Reichert DE, Burbridge AB, Pierce SR, Evers AS, Steinbach JH, Akk G. Analysis of modulation of the ρ1 GABAA receptor by combinations of inhibitory and potentiating neurosteroids reveals shared and distinct binding sites. Molecular Pharmacology. PMID 32675382 DOI: 10.1124/mol.120.119842   
2020 Salazar H, Mischke S, Plested AJR. Measurements of the Timescale and Conformational Space of AMPA Receptor Desensitization. Biophysical Journal. PMID 32559412 DOI: 10.1016/j.bpj.2020.05.029   
2020 Che C, Zeng Y, Xu Y, Lu H, Xu Y, Zhang X, Xiao Y, Li JQ, Qin Z. APAn, a Class of ABA Receptor Agonism/antagonism Switching Probes. Journal of Agricultural and Food Chemistry. PMID 32687337 DOI: 10.1021/acs.jafc.0c02154   
2020 Evenseth LSM, Ocello R, Gabrielsen M, Masetti M, Recanatini M, Sylte I, Cavalli A. Exploring Conformational Dynamics of the Extracellular Domain of the GABA Receptor: A Path-Metadynamics Study. Journal of Chemical Information and Modeling. 60: 2294-2303. PMID 32233432 DOI: 10.1021/acs.jcim.0c00163   
2020 Stephens BS, Ngo T, Kufareva I, Handel TM. Functional anatomy of the full-length CXCR4-CXCL12 complex systematically dissected by quantitative model-guided mutagenesis. Science Signaling. 13. PMID 32665413 DOI: 10.1126/scisignal.aay5024   
2020 Mattedi G, Acosta-Gutiérrez S, Clark T, Gervasio FL. A combined activation mechanism for the glucagon receptor. Proceedings of the National Academy of Sciences of the United States of America. PMID 32571939 DOI: 10.1073/pnas.1921851117   
2020 Oliveira ASF, Ibarra AA, Bermudez I, Casalino L, Gaieb Z, Shoemark DK, Gallagher T, Sessions RB, Amaro RE, Mulholland AJ. Simulations support the interaction of the SARS-CoV-2 spike protein with nicotinic acetylcholine receptors and suggest subtype specificity. Biorxiv : the Preprint Server For Biology. PMID 32743575 DOI: 10.1101/2020.07.16.206680   
2020 Ortega G, Mariottini D, Troina A, Dahlquist FW, Ricci F, Plaxco KW. Rational design to control the trade-off between receptor affinity and cooperativity. Proceedings of the National Academy of Sciences of the United States of America. PMID 32727893 DOI: 10.1073/pnas.2006254117   
2020 Lillo A, Martínez-Pinilla E, Reyes-Resina I, Navarro G, Franco R. Adenosine A and A Receptors Are Able to Interact with Each Other. A Further Piece in the Puzzle of Adenosine Receptor-Mediated Signaling. International Journal of Molecular Sciences. 21. PMID 32709103 DOI: 10.3390/ijms21145070   
2020 Chou TH, Tajima N, Romero-Hernandez A, Furukawa H. Structural Basis of Functional Transitions in Mammalian NMDA Receptors. Cell. PMID 32610085 DOI: 10.1016/j.cell.2020.05.052   
2020 McGrath M, Hoyt H, Pence A, Jayakar SS, Zhou X, Forman SA, Cohen JB, Miller KW, Raines DE. Competitive Antagonism of Etomidate Action by Diazepam: In Vitro GABAA Receptor and In Vivo Zebrafish Studies. Anesthesiology. PMID 32541553 DOI: 10.1097/ALN.0000000000003403   
2020 Dalby NO, Falk-Petersen CB, Leurs U, Scholze P, Krall J, Frølund B, Wellendorph P. Silencing of spontaneous activity at α4β1/3δ GABA receptors in hippocampal granule cells reveals different ligand pharmacology. British Journal of Pharmacology. PMID 32484592 DOI: 10.1111/bph.15146   
2020 Brimson JM, Akula KK, Abbas H, Ferry DR, Kulkarni SK, Russell ST, Tisdale MJ, Tencomnao T, Safrany ST. Simple ammonium salts acting on sigma-1 receptors yield potential treatments for cancer and depression. Scientific Reports. 10: 9251. PMID 32514120 DOI: 10.1038/s41598-020-65849-6   
2020 Fischer JP, Els-Heindl S, Beck-Sickinger AG. Adrenomedullin - Current Perspective on a Peptide Hormone with Significant Therapeutic Potential. Peptides. 170347. PMID 32569606 DOI: 10.1016/j.peptides.2020.170347   
2020 Yu Liao VW, Kusay AS, Balle T, Ahring PK. Heterologous expression of concatenated nicotine acetylcholine receptors: pros and cons of subunit concatenation and recommendations for construct designs. British Journal of Pharmacology. PMID 32627170 DOI: 10.1111/bph.15188   
2020 Motawe ZY, Abdelmaboud SS, Cuevas J, Breslin JW. PRE-084 as a tool to uncover potential therapeutic applications for selective sigma-1 receptor activation. The International Journal of Biochemistry & Cell Biology. 126: 105803. PMID 32668330 DOI: 10.1016/j.biocel.2020.105803   
2020 Clark LJ, Krieger J, White AD, Bondarenko V, Lei S, Fang F, Lee JY, Doruker P, Böttke T, Jean-Alphonse F, Tang P, Gardella TJ, Xiao K, Sutkeviciute I, Coin I, et al. Allosteric interactions in the parathyroid hormone GPCR-arrestin complex formation. Nature Chemical Biology. PMID 32632293 DOI: 10.1038/s41589-020-0567-0   
2020 Gelfuso EA, Reis SL, Aguiar DSR, Faggion SA, Gomes FMM, Galan DT, Peigneur S, Pereira AMS, Mortari MR, Cunha AOS, Tytgat J, Beleboni RO. New insights in the mode of action of (+)-erythravine and (+)-11α-hydroxy-erythravine alkaloids. European Journal of Pharmacology. 173390. PMID 32735983 DOI: 10.1016/j.ejphar.2020.173390   
2020 He YC, Yan YM, Tong HB, Ren ZX, Wang JH, Zhang YB, Chao JB, Wang ML. Benzenebistriazole-strapped calix[4]pyrrole: a neutral anion receptor with CH and NH donor groups that exhibits high sulfate binding affinity and selectivity in aqueous solutions. Chemical Communications (Cambridge, England). PMID 32672309 DOI: 10.1039/d0cc03655b   
2020 Burada AP, Vinnakota R, Kumar J. The Architecture of GluD2 Ionotropic Delta Glutamate Receptor Elucidated by cryo-EM. Journal of Structural Biology. 107546. PMID 32512155 DOI: 10.1016/j.jsb.2020.107546   
2020 Corrie LW, Stokes C, Wilkerson JL, Carroll FI, McMahon LR, Papke RL. Nicotinic Acetylcholine Receptor Accessory Subunits Determine the Activity Profile of Epibatidine Derivatives. Molecular Pharmacology. PMID 32690626 DOI: 10.1124/molpharm.120.000037   
2020 Changeux JP. Golden Anniversary of the Nicotinic Receptor. Neuron. 107: 14-16. PMID 32645305 DOI: 10.1016/j.neuron.2020.05.026   
2020 Intagliata S, Sharma A, King TI, Mesangeau C, Seminerio M, Chin FT, Wilson LL, Matsumoto RR, McLaughlin JP, Avery BA, McCurdy CR. Discovery of a Highly Selective Sigma-2 Receptor Ligand, 1-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one (CM398), with Drug-Like Properties and Antinociceptive Effects In Vivo. The Aaps Journal. 22: 94. PMID 32691179 DOI: 10.1208/s12248-020-00472-x   
2020 Rumpret M, Drylewicz J, Ackermans LJE, Borghans JAM, Medzhitov R, Meyaard L. Functional categories of immune inhibitory receptors. Nature Reviews. Immunology. PMID 32612208 DOI: 10.1038/s41577-020-0352-z   
2020 Tian J, He Y, Deuther-Conrad W, Fu H, Xie F, Zhang Y, Wang T, Zhang X, Zhang J, Brust P, Huang Y, Jia H. Synthesis and evaluation of new 1-oxa-8-azaspiro[4.5]decane derivatives as candidate radioligands for sigma-1 receptors. Bioorganic & Medicinal Chemistry. 28: 115560. PMID 32616183 DOI: 10.1016/j.bmc.2020.115560   
2020 Friedman S, Tauber M, Ben-Chaim Y. Sodium ions allosterically modulate the M2 muscarinic receptor. Scientific Reports. 10: 11177. PMID 32636499 DOI: 10.1038/s41598-020-68133-9   
2020 Li X, Shen L, Hua T, Liu ZJ. Structural and Functional Insights into Cannabinoid Receptors. Trends in Pharmacological Sciences. PMID 32739033 DOI: 10.1016/j.tips.2020.06.010   
2020 Islam MT, Molla S, Zihad SMNK, Umer M, Rahman MS, Zaman F, Das AK, Afzal MI, Salehi B, Akter MS, Mubarak MS, Martins N, Imran M, Chaudhary N, Iqbal Z, et al. Ascorbic acid antagonizes the sedative effect of diazepam possibly through inhibition of GABA(Aρ₁) and GABA(B1) receptors. Cellular and Molecular Biology (Noisy-Le-Grand, France). 66: 15-19. PMID 32583769   
2020 Yang X, Dilweg MA, Osemwengie D, Burggraaff L, van der Es D, Heitman LH, IJzerman AP. Design and Pharmacological Profile of a Novel Covalent Partial Agonist for the Adenosine A Receptor. Biochemical Pharmacology. 114144. PMID 32653590 DOI: 10.1016/j.bcp.2020.114144   
2020 Rauschenberger V, Wardenburg NV, Schaefer N, Ogino K, Hirata H, Lillesaar C, Kluck CJ, Meinck HM, Borrmann M, Weishaupt A, Doppler K, Wickel J, Geis C, Sommer C, Villmann C. GlyR autoantibodies impair receptor function and induce motor dysfunction. Annals of Neurology. PMID 32588476 DOI: 10.1002/ana.25832   
2020 Spillmann M, Thurner L, Romantini N, Zimmermann M, Meger B, Behe M, Waldhoer M, Schertler GFX, Berger P. New Insights into Arrestin Recruitment to GPCRs. International Journal of Molecular Sciences. 21. PMID 32668755 DOI: 10.3390/ijms21144949   
2020 Cui Y, Peng R, Song H, Tong Z, Qu X, Liu S, Zhao X, Chai Y, Wang P, Gao GF, Qi J. Molecular basis of Coxsackievirus A10 entry using the two-in-one attachment and uncoating receptor KRM1. Proceedings of the National Academy of Sciences of the United States of America. PMID 32690697 DOI: 10.1073/pnas.2005341117   
2020 Cui Y, Peng R, Song H, Tong Z, Qu X, Liu S, Zhao X, Chai Y, Wang P, Gao GF, Qi J. Molecular basis of Coxsackievirus A10 entry using the two-in-one attachment and uncoating receptor KRM1. Proceedings of the National Academy of Sciences of the United States of America. PMID 32690697 DOI: 10.1073/pnas.2005341117   
2020 Andoh T, Suzuki K, Konno M, Tsuneyama K, Kuraishi Y. Pharmacological Characterization of a Novel Mouse Model of Cholestatic Pruritus. Biological & Pharmaceutical Bulletin. 43: 1111-1117. PMID 32612073 DOI: 10.1248/bpb.b20-00097   
2020 Al Noman MA, Kyzer J, Chung SSW, Wolgemuth DJ, Georg GI. Retinoic acid receptor antagonists for male contraception: Current status. Biology of Reproduction. PMID 32671394 DOI: 10.1093/biolre/ioaa122   
2020 Cuellar-Camacho JL, Bhatia S, Reiter-Scherer V, Lauster D, Liese S, Rabe JP, Herrmann A, Haag R. Quantification of multivalent interactions between sialic acid and influenza A virus spike proteins by single molecule force spectroscopy. Journal of the American Chemical Society. PMID 32538085 DOI: 10.1021/jacs.0c02852   
2020 Nguyen T, Marusich J, Li JX, Zhang Y. Neuropeptide FF and Its Receptors: Therapeutic Applications and Ligand Development. Journal of Medicinal Chemistry. PMID 32673481 DOI: 10.1021/acs.jmedchem.0c00643   
2020 Krintel C, Dorosz J, Larsen AH, Seneca Thorsen T, Venskutonytė R, Mirza O, Gajhede M, Boesen T, Kastrup JS. Binding of a negative allosteric modulator and competitive antagonist can occur simultaneously at the ionotropic glutamate receptor GluA2. The Febs Journal. PMID 32543078 DOI: 10.1111/febs.15455   
2020 Kim HR, Xu J, Maeda S, Duc NM, Ahn D, Du Y, Chung KY. Structural mechanism underlying primary and secondary coupling between GPCRs and the Gi/o family. Nature Communications. 11: 3160. PMID 32572026 DOI: 10.1038/s41467-020-16975-2   
2020 Ghali MGZ, Arborelius UP, Yaşargil MG. β-Adrenergic receptor structure and function: molecular insights guiding the development of novel therapeutic strategies to treat malignancy. Journal of Receptor and Signal Transduction Research. 1-15. PMID 32456520 DOI: 10.1080/10799893.2020.1759091   
2020 Chin AC, Yovanno RA, Wied TJ, Gershman A, Lau AY. D-Serine Potently Drives Ligand-Binding Domain Closure in the Ionotropic Glutamate Receptor GluD2. Structure (London, England : 1993). PMID 32735769 DOI: 10.1016/j.str.2020.07.005   
2020 Roderer D, Bröcker F, Sitsel O, Kaplonek P, Leidreiter F, Seeberger PH, Raunser S. Glycan-dependent cell adhesion mechanism of Tc toxins. Nature Communications. 11: 2694. PMID 32483155 DOI: 10.1038/s41467-020-16536-7   
2020 Zhang X, Meng R, Wang H, Xing J. Differential Effects of Components in Artemisia annua Extract on the Induction of Drug-Metabolizing Enzyme Expression Mediated by Nuclear Receptors. Planta Medica. PMID 32557519 DOI: 10.1055/a-1178-0852   
2020 Ansell TB, Song W, Sansom MSP. The Glycosphingolipid GM3 Modulates Conformational Dynamics of the Glucagon Receptor. Biophysical Journal. PMID 32610088 DOI: 10.1016/j.bpj.2020.06.009   
2020 Rufener L, Kaur K, Sarr A, Aaen SM, Horsberg TE. Nicotinic acetylcholine receptors: Ex-vivo expression of functional, non-hybrid, heteropentameric receptors from a marine arthropod, Lepeophtheirus salmonis. Plos Pathogens. 16: e1008715. PMID 32716968 DOI: 10.1371/journal.ppat.1008715   
2020 Pflüger P, Regner GG, Luft JG, Gonçalves DA, Krebs C, Fontenla JA, Pereira P. Gamma-decanolactone attenuates acute and chronic seizures in mice: a possible role of adenosine A1 receptors. Behavioural Pharmacology. PMID 32701527 DOI: 10.1097/FBP.0000000000000554