Keith A. Wafford - Publications

Affiliations: 
Eli Lilly, Indianapolis, IN, United States 

131 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Wood CM, Nicolas CS, Choi SL, Roman E, Nylander I, Fernandez-Teruel A, Kiianmaa K, Bienkowski P, de Jong TR, Colombo G, Chastagnier D, Wafford KA, Collingridge GL, Wildt SJ, Conway-Campbell BL, et al. Prevalence and influence of cys407* Grm2 mutation in Hannover-derived Wistar rats: mGlu2 receptor loss links to alcohol intake, risk taking and emotional behaviour. Neuropharmacology. PMID 26987983 DOI: 10.1016/j.neuropharm.2016.03.020  0.76
2015 Post A, Smart TS, Krikke-Workel J, Dawson GR, Harmer CJ, Browning M, Jackson K, Kakar R, Mohs R, Statnick M, Wafford K, McCarthy A, Barth V, Witkin JM. A Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinical Studies. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26585287 DOI: 10.1038/npp.2015.348  0.76
2015 Steinberg EA, Wafford KA, Brickley SG, Franks NP, Wisden W. The role of K₂p channels in anaesthesia and sleep. PflüGers Archiv : European Journal of Physiology. 467: 907-16. PMID 25482669 DOI: 10.1007/s00424-014-1654-4  0.76
2015 Wodarski R, Schuh-Hofer S, Yurek DA, Wafford KA, Gilmour G, Treede RD, Kennedy JD. Development and pharmacological characterization of a model of sleep disruption-induced hypersensitivity in the rat. European Journal of Pain (London, England). 19: 554-66. PMID 25195796 DOI: 10.1002/ejp.580  0.76
2013 Jensen ML, Wafford KA, Brown AR, Belelli D, Lambert JJ, Mirza NR. A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (DS2) at human recombinant and rodent native GABA(A) receptors. British Journal of Pharmacology. 168: 1118-32. PMID 23061935 DOI: 10.1111/bph.12001  0.76
2013 Gilmour G, Broad LM, Wafford KA, Britton T, Colvin EM, Fivush A, Gastambide F, Getman B, Heinz BA, McCarthy AP, Prieto L, Shanks E, Smith JW, Taboada L, Edgar DM, et al. In vitro characterisation of the novel positive allosteric modulators of the mGluâ‚… receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat. Neuropharmacology. 64: 224-39. PMID 22884720 DOI: 10.1016/j.neuropharm.2012.07.030  0.76
2012 Phillips KG, Bartsch U, McCarthy AP, Edgar DM, Tricklebank MD, Wafford KA, Jones MW. Decoupling of sleep-dependent cortical and hippocampal interactions in a neurodevelopmental model of schizophrenia. Neuron. 76: 526-33. PMID 23141065 DOI: 10.1016/j.neuron.2012.09.016  0.76
2012 Phillips KG, Cotel MC, McCarthy AP, Edgar DM, Tricklebank M, O'Neill MJ, Jones MW, Wafford KA. Differential effects of NMDA antagonists on high frequency and gamma EEG oscillations in a neurodevelopmental model of schizophrenia. Neuropharmacology. 62: 1359-70. PMID 21521646 DOI: 10.1016/j.neuropharm.2011.04.006  0.76
2012 Mirza NR, Atack J, Wafford K. GABA A receptor subtypes: Novel targets for novel medicines Advances in Pharmacological Sciences. 2012. DOI: 10.1155/2012/529861  0.76
2011 Fell MJ, Witkin JM, Falcone JF, Katner JS, Perry KW, Hart J, Rorick-Kehn L, Overshiner CD, Rasmussen K, Chaney SF, Benvenga MJ, Li X, Marlow DL, Thompson LK, Luecke SK, ... Wafford KA, et al. N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide (THIIC), a novel metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties: in vivo profiling suggests a link between behavioral and central nervous system neurochemical changes. The Journal of Pharmacology and Experimental Therapeutics. 336: 165-77. PMID 20947638 DOI: 10.1124/jpet.110.172957  0.76
2011 Atack JR, Hallett DJ, Tye S, Wafford KA, Ryan C, Sanabria-Bohórquez SM, Eng WS, Gibson RE, Burns HD, Dawson GR, Carling RW, Street LJ, Pike A, De Lepeleire I, Van Laere K, et al. Preclinical and clinical pharmacology of TPA023B, a GABAA receptor α2/α3 subtype-selective partial agonist. Journal of Psychopharmacology (Oxford, England). 25: 329-44. PMID 20156926 DOI: 10.1177/0269881109354928  0.76
2011 Atack JR, Wafford KA, Street LJ, Dawson GR, Tye S, Van Laere K, Bormans G, Sanabria-Bohórquez SM, De Lepeleire I, de Hoon JN, Van Hecken A, Burns HD, McKernan RM, Murphy MG, Hargreaves RJ. MRK-409 (MK-0343), a GABAA receptor subtype-selective partial agonist, is a non-sedating anxiolytic in preclinical species but causes sedation in humans. Journal of Psychopharmacology (Oxford, England). 25: 314-28. PMID 20147571 DOI: 10.1177/0269881109354927  0.76
2010 Mortensen M, Ebert B, Wafford K, Smart TG. Distinct activities of GABA agonists at synaptic- and extrasynaptic-type GABAA receptors. The Journal of Physiology. 588: 1251-68. PMID 20176630 DOI: 10.1113/jphysiol.2009.182444  0.76
2009 Atack JR, Maubach KA, Wafford KA, O'Connor D, Rodrigues AD, Evans DC, Tattersall FD, Chambers MS, MacLeod AM, Eng WS, Ryan C, Hostetler E, Sanabria SM, Gibson RE, Krause S, et al. In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist. The Journal of Pharmacology and Experimental Therapeutics. 331: 470-84. PMID 19704033 DOI: 10.1124/jpet.109.157636  0.76
2009 Wafford KA, van Niel MB, Ma QP, Horridge E, Herd MB, Peden DR, Belelli D, Lambert JJ. Novel compounds selectively enhance delta subunit containing GABA A receptors and increase tonic currents in thalamus. Neuropharmacology. 56: 182-9. PMID 18762200 DOI: 10.1016/j.neuropharm.2008.08.004  0.76
2008 Wafford KA, Ebert B. Emerging anti-insomnia drugs: tackling sleeplessness and the quality of wake time. Nature Reviews. Drug Discovery. 7: 530-40. PMID 18511929 DOI: 10.1038/nrd2464  0.76
2008 Herd MB, Haythornthwaite AR, Rosahl TW, Wafford KA, Homanics GE, Lambert JJ, Belelli D. The expression of GABAA beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells. The Journal of Physiology. 586: 989-1004. PMID 18079158 DOI: 10.1113/jphysiol.2007.146746  0.76
2008 Peden DR, Petitjean CM, Herd MB, Durakoglugil MS, Rosahl TW, Wafford K, Homanics GE, Belelli D, Fritschy JM, Lambert JJ. Developmental maturation of synaptic and extrasynaptic GABAA receptors in mouse thalamic ventrobasal neurones. The Journal of Physiology. 586: 965-87. PMID 18063661 DOI: 10.1113/jphysiol.2007.145375  0.76
2007 Fradley RL, Guscott MR, Bull S, Hallett DJ, Goodacre SC, Wafford KA, Garrett EM, Newman RJ, O'Meara GF, Whiting PJ, Rosahl TW, Dawson GR, Reynolds DS, Atack JR. Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands. Journal of Psychopharmacology (Oxford, England). 21: 384-91. PMID 17092983 DOI: 10.1177/0269881106067255  0.76
2006 Atack JR, Bayley PJ, Seabrook GR, Wafford KA, McKernan RM, Dawson GR. L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for alpha5-containing GABAA receptors. Neuropharmacology. 51: 1023-9. PMID 17046030 DOI: 10.1016/j.neuropharm.2006.04.018  0.76
2006 Atack JR, Bayley PJ, Fletcher SR, McKernan RM, Wafford KA, Dawson GR. The proconvulsant effects of the GABAA alpha5 subtype-selective compound RY-080 may not be alpha5-mediated. European Journal of Pharmacology. 548: 77-82. PMID 16962577 DOI: 10.1016/j.ejphar.2006.02.055  0.76
2006 Groves JO, Guscott MR, Hallett DJ, Rosahl TW, Pike A, Davies A, Wafford KA, Reynolds DS. The role of GABAbeta2 subunit-containing receptors in mediating the anticonvulsant and sedative effects of loreclezole. The European Journal of Neuroscience. 24: 167-74. PMID 16882014 DOI: 10.1111/j.1460-9568.2006.04890.x  0.76
2006 Ebert B, Wafford KA, Deacon S. Treating insomnia: Current and investigational pharmacological approaches. Pharmacology & Therapeutics. 112: 612-29. PMID 16876255 DOI: 10.1016/j.pharmthera.2005.04.014  0.76
2006 Rosahl TW, Wingrove PB, Hunt V, Fradley RL, Lawrence JM, Heavens RP, Treacey P, Usala M, Macaulay A, Bonnert TP, Whiting PJ, Wafford KA. A genetically modified mouse model probing the selective action of ifenprodil at the N-methyl-D-aspartate type 2B receptor. Molecular and Cellular Neurosciences. 33: 47-56. PMID 16870468 DOI: 10.1016/j.mcn.2006.06.006  0.76
2006 Simpson PB, Wafford KA. New directions in kinetic high information content assays. Drug Discovery Today. 11: 237-44. PMID 16639807  0.76
2006 Carling RW, Russell MG, Moore KW, Mitchinson A, Guiblin A, Smith A, Wafford KA, Marshall G, Atack JR, Street LJ. 2,3,7-Trisubstituted pyrazolo[1,5-d][1,2,4]triazines: functionally selective GABAA alpha3-subtype agonists. Bioorganic & Medicinal Chemistry Letters. 16: 3550-4. PMID 16621541 DOI: 10.1016/j.bmcl.2006.03.081  0.76
2006 Lewis RT, Blackaby WP, Blackburn T, Jennings AS, Pike A, Wilson RA, Hallett DJ, Cook SM, Ferris P, Marshall GR, Reynolds DS, Sheppard WF, Smith AJ, Sohal B, Stanley J, ... ... Wafford KA, et al. A pyridazine series of alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety. Journal of Medicinal Chemistry. 49: 2600-10. PMID 16610803 DOI: 10.1021/jm051144x  0.76
2006 Cheng VY, Martin LJ, Elliott EM, Kim JH, Mount HT, Taverna FA, Roder JC, Macdonald JF, Bhambri A, Collinson N, Wafford KA, Orser BA. Alpha5GABAA receptors mediate the amnestic but not sedative-hypnotic effects of the general anesthetic etomidate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 3713-20. PMID 16597725 DOI: 10.1523/JNEUROSCI.5024-05.2006  0.76
2006 Russell MG, Carling RW, Street LJ, Hallett DJ, Goodacre S, Mezzogori E, Reader M, Cook SM, Bromidge FA, Newman R, Smith AJ, Wafford KA, Marshall GR, Reynolds DS, Dias R, et al. Discovery of imidazo[1,2-b][1,2,4]triazines as GABA(A) alpha2/3 subtype selective agonists for the treatment of anxiety. Journal of Medicinal Chemistry. 49: 1235-8. PMID 16480260 DOI: 10.1021/jm051200u  0.76
2006 Atack JR, Pike A, Marshall G, Stanley J, Lincoln R, Cook SM, Lewis RT, Blackaby WP, Goodacre SC, McKernan RM, Dawson GR, Wafford KA, Reynolds DS. The in vivo properties of pagoclone in rat are most likely mediated by 5'-hydroxy pagoclone. Neuropharmacology. 50: 677-89. PMID 16430927 DOI: 10.1016/j.neuropharm.2005.11.014  0.76
2006 Blackaby WP, Atack JR, Bromidge F, Castro JL, Goodacre SC, Hallett DJ, Lewis RT, Marshall GR, Pike A, Smith AJ, Street LJ, Tattersall DF, Wafford KA. Imidazo[1,2-a]pyrimidines as functionally selective GABA(A) ligands. Bioorganic & Medicinal Chemistry Letters. 16: 1175-9. PMID 16406613 DOI: 10.1016/j.bmcl.2005.11.112  0.76
2006 Goodacre SC, Street LJ, Hallett DJ, Crawforth JM, Kelly S, Owens AP, Blackaby WP, Lewis RT, Stanley J, Smith AJ, Ferris P, Sohal B, Cook SM, Pike A, Brown N, ... Wafford KA, et al. Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABA(A)alpha2/alpha3 binding site agonists for the treatment of anxiety disorders. Journal of Medicinal Chemistry. 49: 35-8. PMID 16392789 DOI: 10.1021/jm051065l  0.76
2006 Jennings AS, Lewis RT, Russell MG, Hallett DJ, Street LJ, Castro JL, Atack JR, Cook SM, Lincoln R, Stanley J, Smith AJ, Reynolds DS, Sohal B, Pike A, Marshall GR, ... Wafford KA, et al. Imidazo[1,2-b][1,2,4]triazines as alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety. Bioorganic & Medicinal Chemistry Letters. 16: 1477-80. PMID 16386900 DOI: 10.1016/j.bmcl.2005.12.044  0.76
2006 Goodacre SC, Hallett DJ, Carling RW, Castro JL, Reynolds DS, Pike A, Wafford KA, Newman R, Atack JR, Street LJ. Imidazo[1,2-a]pyrazin-8-ones, imidazo[1,2-d][1,2,4]triazin-8-ones and imidazo[2,1-f][1,2,4]triazin-8-ones as alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety. Bioorganic & Medicinal Chemistry Letters. 16: 1582-5. PMID 16384707 DOI: 10.1016/j.bmcl.2005.12.027  0.76
2006 Wafford KA, Ebert B. Gaboxadol--a new awakening in sleep. Current Opinion in Pharmacology. 6: 30-6. PMID 16368265 DOI: 10.1016/j.coph.2005.10.004  0.76
2006 Dawson GR, Maubach KA, Collinson N, Cobain M, Everitt BJ, MacLeod AM, Choudhury HI, McDonald LM, Pillai G, Rycroft W, Smith AJ, Sternfeld F, Tattersall FD, Wafford KA, Reynolds DS, et al. An inverse agonist selective for alpha5 subunit-containing GABAA receptors enhances cognition. The Journal of Pharmacology and Experimental Therapeutics. 316: 1335-45. PMID 16326923 DOI: 10.1124/jpet.105.092320  0.76
2006 Jones P, Atack JR, Braun MP, Cato BP, Chambers MS, O'Connor D, Cook SM, Hobbs SC, Maxey R, Szekeres HJ, Szeto N, Wafford KA, MacLeod AM. Pharmacokinetics and metabolism studies on (3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally selective GABA(A) alpha5 inverse agonist for cognitive dysfunction. Bioorganic & Medicinal Chemistry Letters. 16: 872-5. PMID 16303300 DOI: 10.1016/j.bmcl.2005.11.012  0.76
2006 Borghese CM, Stórustovu Sí, Ebert B, Herd MB, Belelli D, Lambert JJ, Marshall G, Wafford KA, Harris RA. The delta subunit of gamma-aminobutyric acid type A receptors does not confer sensitivity to low concentrations of ethanol. The Journal of Pharmacology and Experimental Therapeutics. 316: 1360-8. PMID 16272217 DOI: 10.1124/jpet.105.092452  0.76
2006 Atack JR, Wafford KA, Tye SJ, Cook SM, Sohal B, Pike A, Sur C, Melillo D, Bristow L, Bromidge F, Ragan I, Kerby J, Street L, Carling R, Castro JL, et al. TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates. The Journal of Pharmacology and Experimental Therapeutics. 316: 410-22. PMID 16183706 DOI: 10.1124/jpet.105.089920  0.76
2006 Ebert B, Wafford KA. Benzodiazepine receptor agonists and insomnia: Is subtype selectivity lost in translation? Drug Discovery Today: Therapeutic Strategies. 3: 547-554. DOI: 10.1016/j.ddstr.2006.11.008  0.76
2005 Belelli D, Peden DR, Rosahl TW, Wafford KA, Lambert JJ. Extrasynaptic GABAA receptors of thalamocortical neurons: a molecular target for hypnotics. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11513-20. PMID 16354909 DOI: 10.1523/JNEUROSCI.2679-05.2005  0.76
2005 Dias R, Sheppard WF, Fradley RL, Garrett EM, Stanley JL, Tye SJ, Goodacre S, Lincoln RJ, Cook SM, Conley R, Hallett D, Humphries AC, Thompson SA, Wafford KA, Street LJ, et al. Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10682-8. PMID 16291941 DOI: 10.1523/JNEUROSCI.1166-05.2005  0.76
2005 Carling RW, Madin A, Guiblin A, Russell MG, Moore KW, Mitchinson A, Sohal B, Pike A, Cook SM, Ragan IC, McKernan RM, Quirk K, Ferris P, Marshall G, Thompson SA, ... Wafford KA, et al. 7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine: a functionally selective gamma-aminobutyric acid(A) (GABA(A)) alpha2/alpha3-subtype selective agonist that exhibits potent anxiolytic activity but is not sedating in animal models. Journal of Medicinal Chemistry. 48: 7089-92. PMID 16279764 DOI: 10.1021/jm058034a  0.76
2005 Blackaby WP, Atack JR, Bromidge F, Lewis R, Russell MGN, Smith A, Wafford K, McKernan RM, Street LJ, Castro JL. Pyrazolopyridinones as functionally selective GABAA ligands Bioorganic and Medicinal Chemistry Letters. 15: 4998-5002. PMID 16153832 DOI: 10.1016/j.bmcl.2005.08.006  0.76
2005 Russell MG, Carling RW, Atack JR, Bromidge FA, Cook SM, Hunt P, Isted C, Lucas M, McKernan RM, Mitchinson A, Moore KW, Narquizian R, Macaulay AJ, Thomas D, Thompson SA, ... Wafford KA, et al. Discovery of functionally selective 7,8,9,10-tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a]phthalazines as GABA A receptor agonists at the alpha3 subunit. Journal of Medicinal Chemistry. 48: 1367-83. PMID 15743180 DOI: 10.1021/jm040883v  0.76
2005 Wafford KA. GABAA receptor subtypes: any clues to the mechanism of benzodiazepine dependence? Current Opinion in Pharmacology. 5: 47-52. PMID 15661625 DOI: 10.1016/j.coph.2004.08.006  0.76
2005 Atack JR, Hutson PH, Collinson N, Marshall G, Bentley G, Moyes C, Cook SM, Collins I, Wafford K, McKernan RM, Dawson GR. Anxiogenic properties of an inverse agonist selective for alpha3 subunit-containing GABA A receptors. British Journal of Pharmacology. 144: 357-66. PMID 15655523 DOI: 10.1038/sj.bjp.0706056  0.76
2005 Lambert JJ, Haythornthwaite AR, Peden DR, Herd MB, Wafford KA, Rosahl TW, Belelli D. The GABAA receptor: An important target for the general anaesthetic etomidate International Congress Series. 1283: 67-72. DOI: 10.1016/j.ics.2005.07.071  0.76
2004 Caraiscos VB, Newell JG, You-Ten KE, Elliott EM, Rosahl TW, Wafford KA, MacDonald JF, Orser BA. Selective enhancement of tonic GABAergic inhibition in murine hippocampal neurons by low concentrations of the volatile anesthetic isoflurane. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 8454-8. PMID 15456818 DOI: 10.1523/JNEUROSCI.2063-04.2004  0.76
2004 Priest BT, Garcia ML, Middleton RE, Brochu RM, Clark S, Dai G, Dick IE, Felix JP, Liu CJ, Reiseter BS, Schmalhofer WA, Shao PP, Tang YS, Chou MZ, Kohler MG, ... ... Wafford KA, et al. A disubstituted succinamide is a potent sodium channel blocker with efficacy in a rat pain model. Biochemistry. 43: 9866-76. PMID 15274641 DOI: 10.1021/bi0493259  0.76
2004 Street LJ, Sternfeld F, Jelley RA, Reeve AJ, Carling RW, Moore KW, McKernan RM, Sohal B, Cook S, Pike A, Dawson GR, Bromidge FA, Wafford KA, Seabrook GR, Thompson SA, et al. Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site. Journal of Medicinal Chemistry. 47: 3642-57. PMID 15214791 DOI: 10.1021/jm0407613  0.76
2004 Mitchinson A, Atack JR, Blurton P, Carling RW, Castro JL, Curley KS, Russell MG, Marshall G, McKernan RM, Moore KW, Narquizian R, Smith A, Street LJ, Thompson SA, Wafford K. 2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones: functionally selective benzodiazepine binding site ligands on the GABAA receptor. Bioorganic & Medicinal Chemistry Letters. 14: 3441-4. PMID 15177449 DOI: 10.1016/j.bmcl.2004.04.085  0.76
2004 Cirone J, Rosahl TW, Reynolds DS, Newman RJ, O'Meara GF, Hutson PH, Wafford KA. Gamma-aminobutyric acid type A receptor beta 2 subunit mediates the hypothermic effect of etomidate in mice. Anesthesiology. 100: 1438-45. PMID 15166563 DOI: 10.1097/00000542-200406000-00016  0.76
2004 Wafford KA, Macaulay AJ, Fradley R, O'Meara GF, Reynolds DS, Rosahl TW. Differentiating the role of gamma-aminobutyric acid type A (GABAA) receptor subtypes. Biochemical Society Transactions. 32: 553-6. PMID 15157182 DOI: 10.1042/BST0320553  0.76
2004 Connolly CN, Wafford KA. The Cys-loop superfamily of ligand-gated ion channels: the impact of receptor structure on function. Biochemical Society Transactions. 32: 529-34. PMID 15157178 DOI: 10.1042/BST0320529  0.76
2004 Thompson SA, Wheat L, Brown NA, Wingrove PB, Pillai GV, Whiting PJ, Adkins C, Woodward CH, Smith AJ, Simpson PB, Collins I, Wafford KA. Salicylidene salicylhydrazide, a selective inhibitor of beta 1-containing GABAA receptors. British Journal of Pharmacology. 142: 97-106. PMID 15100159 DOI: 10.1038/sj.bjp.0705689  0.76
2004 Sternfeld F, Carling RW, Jelley RA, Ladduwahetty T, Merchant KJ, Moore KW, Reeve AJ, Street LJ, O'Connor D, Sohal B, Atack JR, Cook S, Seabrook G, Wafford K, Tattersall FD, et al. Selective, orally active gamma-aminobutyric acidA alpha5 receptor inverse agonists as cognition enhancers. Journal of Medicinal Chemistry. 47: 2176-9. PMID 15084116 DOI: 10.1021/jm031076j  0.76
2004 McCauley JA, Theberge CR, Romano JJ, Billings SB, Anderson KD, Claremon DA, Freidinger RM, Bednar RA, Mosser SD, Gaul SL, Connolly TM, Condra CL, Xia M, Cunningham ME, Bednar B, ... ... Wafford KA, et al. NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles. Journal of Medicinal Chemistry. 47: 2089-96. PMID 15056006 DOI: 10.1021/jm030483s  0.76
2004 Carling RW, Moore KW, Street LJ, Wild D, Isted C, Leeson PD, Thomas S, O'Connor D, McKernan RM, Quirk K, Cook SM, Atack JR, Wafford KA, Thompson SA, Dawson GR, et al. 3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor ligands with alpha 2, alpha 3, and alpha 5-subtype binding selectivity over alpha 1. Journal of Medicinal Chemistry. 47: 1807-22. PMID 15027873 DOI: 10.1021/jm031020p  0.76
2004 Crawforth J, Atack JR, Cook SM, Gibson KR, Nadin A, Owens AP, Pike A, Rowley M, Smith AJ, Sohal B, Sternfeld F, Wafford K, Street LJ. Tricyclic pyridones as functionally selective human GABA Aα2/3 receptor-ion channel ligands Bioorganic and Medicinal Chemistry Letters. 14: 1679-1682. PMID 15026049 DOI: 10.1016/j.bmcl.2004.01.057  0.76
2004 Caraiscos VB, Elliott EM, You-Ten KE, Cheng VY, Belelli D, Newell JG, Jackson MF, Lambert JJ, Rosahl TW, Wafford KA, MacDonald JF, Orser BA. Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors. Proceedings of the National Academy of Sciences of the United States of America. 101: 3662-7. PMID 14993607 DOI: 10.1073/pnas.0307231101  0.76
2004 McCabe C, Shaw D, Atack JR, Street LJ, Wafford KA, Dawson GR, Reynolds DS, Leslie JC. Subtype-selective GABAergic drugs facilitate extinction of mouse operant behaviour. Neuropharmacology. 46: 171-8. PMID 14680756 DOI: 10.1016/j.neuropharm.2003.09.004  0.76
2003 Priestley CM, Williamson EM, Wafford KA, Sattelle DB. Thymol, a constituent of thyme essential oil, is a positive allosteric modulator of human GABA(A) receptors and a homo-oligomeric GABA receptor from Drosophila melanogaster. British Journal of Pharmacology. 140: 1363-72. PMID 14623762 DOI: 10.1038/sj.bjp.0705542  0.76
2003 Usala M, Thompson SA, Whiting PJ, Wafford KA. Activity of chlormethiazole at human recombinant GABA(A) and NMDA receptors. British Journal of Pharmacology. 140: 1045-50. PMID 14530209 DOI: 10.1038/sj.bjp.0705540  0.76
2003 Reynolds DS, Rosahl TW, Cirone J, O'Meara GF, Haythornthwaite A, Newman RJ, Myers J, Sur C, Howell O, Rutter AR, Atack J, Macaulay AJ, Hadingham KL, Hutson PH, Belelli D, ... ... Wafford KA, et al. Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8608-17. PMID 13679430  0.76
2003 Mortensen M, Wafford KA, Wingrove P, Ebert B. Pharmacology of GABA(A) receptors exhibiting different levels of spontaneous activity. European Journal of Pharmacology. 476: 17-24. PMID 12969744 DOI: 10.1016/S0014-2999(03)02125-3  0.76
2003 McIlhinney RAJ, Philipps E, Le Bourdelles B, Grimwood S, Wafford K, Sandhu S, Whiting P. Assembly of N-methyl-D-aspartate (NMDA) receptors Biochemical Society Transactions. 31: 865-868. PMID 12887323 DOI: 10.1042/BST0310865  0.76
2003 Maksay G, Thompson SA, Wafford KA. The pharmacology of spontaneously open alpha 1 beta 3 epsilon GABA A receptor-ionophores. Neuropharmacology. 44: 994-1002. PMID 12763092 DOI: 10.1016/S0028-3908(03)00116-3  0.76
2003 Claiborne CF, McCauley JA, Libby BE, Curtis NR, Diggle HJ, Kulagowski JJ, Michelson SR, Anderson KD, Claremon DA, Freidinger RM, Bednar RA, Mosser SD, Gaul SL, Connolly TM, Condra CL, ... ... Wafford KA, et al. Orally efficacious NR2B-selective NMDA receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 13: 697-700. PMID 12639561 DOI: 10.1016/S0960-894X(02)01061-2  0.76
2003 Curtis NR, Diggle HJ, Kulagowski JJ, London C, Grimwood S, Hutson PH, Murray F, Richards P, Macaulay A, Wafford KA. Novel N1-(benzyl)cinnamamidine derived NR2B subtype-selective NMDA receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 13: 693-6. PMID 12639560 DOI: 10.1016/S0960-894X(02)01060-0  0.76
2002 Thompson SA, Bonnert TP, Cagetti E, Whiting PJ, Wafford KA. Overexpression of the GABA(A) receptor epsilon subunit results in insensitivity to anaesthetics. Neuropharmacology. 43: 662-8. PMID 12367611 DOI: 10.1016/S0028-3908(02)00162-4  0.76
2002 Grimwood S, Wafford KA, Macaulay A, Hutson PH. N-Methyl-D-aspartate receptor subtype-selectivity of homoquinolinate: an electrophysiological and radioligand binding study using both native and recombinant receptors. Journal of Neurochemistry. 82: 794-800. PMID 12358784 DOI: 10.1046/j.1471-4159.2002.01014.x  0.76
2002 Brown N, Kerby J, Bonnert TP, Whiting PJ, Wafford KA. Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors. British Journal of Pharmacology. 136: 965-74. PMID 12145096 DOI: 10.1038/sj.bjp.0704795  0.76
2002 Collins I, Moyes C, Davey WB, Rowley M, Bromidge FA, Quirk K, Atack JR, McKernan RM, Thompson SA, Wafford K, Dawson GR, Pike A, Sohal B, Tsou NN, Ball RG, et al. 3-Heteroaryl-2-pyridones: benzodiazepine site ligands with functional delectivity for alpha 2/alpha 3-subtypes of human GABA(A) receptor-ion channels. Journal of Medicinal Chemistry. 45: 1887-900. PMID 11960500 DOI: 10.1021/jm0110789  0.76
2002 Thompson SA, Wingrove PB, Connelly L, Whiting PJ, Wafford KA. Tracazolate reveals a novel type of allosteric interaction with recombinant gamma-aminobutyric acid(A) receptors. Molecular Pharmacology. 61: 861-9. PMID 11901225 DOI: 10.1124/mol.61.4.861  0.76
2002 Chambers MS, Atack JR, Bromidge FA, Broughton HB, Cook S, Dawson GR, Hobbs SC, Maubach KA, Reeve AJ, Seabrook GR, Wafford K, Ma AM. 6,7-Dihydro-2-benzothiophen-4(5H)-ones: A novel class of GABA-A α5 receptor inverse agonists Journal of Medicinal Chemistry. 45: 1176-1179. PMID 11881985 DOI: 10.1021/jm010471b  0.76
2002 Wingrove PB, Safo P, Wheat L, Thompson SA, Wafford KA, Whiting PJ. Mechanism of alpha-subunit selectivity of benzodiazepine pharmacology at gamma-aminobutyric acid type A receptors. European Journal of Pharmacology. 437: 31-9. PMID 11864636 DOI: 10.1016/S0014-2999(02)01279-7  0.76
2001 Thompson SA, Wafford K. Mechanism of action of general anaesthetics - New information from molecular pharmacology Current Opinion in Pharmacology. 1: 78-83. PMID 11712540 DOI: 10.1016/S1471-4892(01)00013-3  0.76
2001 Ebert B, Mortensen M, Thompson SA, Kehler J, Wafford KA, Krogsgaard-Larsen P. Bioisosteric determinants for subtype selectivity of ligands for heteromeric GABA(A) receptors. Bioorganic & Medicinal Chemistry Letters. 11: 1573-7. PMID 11412984 DOI: 10.1016/S0960-894X(01)00184-6  0.76
2001 Sur C, Wafford KA, Reynolds DS, Hadingham KL, Bromidge F, Macaulay A, Collinson N, O'Meara G, Howell O, Newman R, Myers J, Atack JR, Dawson GR, McKernan RM, Whiting PJ, et al. Loss of the major GABA(A) receptor subtype in the brain is not lethal in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 3409-18. PMID 11331371  0.76
2001 Caldwell MA, He X, Wilkie N, Pollack S, Marshall G, Wafford KA, Svendsen CN. Growth factors regulate the survival and fate of cells derived from human neurospheres. Nature Biotechnology. 19: 475-9. PMID 11329020 DOI: 10.1038/88158  0.76
2001 Smith AJ, Alder L, Silk J, Adkins C, Fletcher AE, Scales T, Kerby J, Marshall G, Wafford KA, McKernan RM, Atack JR. Effect of alpha subunit on allosteric modulation of ion channel function in stably expressed human recombinant gamma-aminobutyric acid(A) receptors determined using (36)Cl ion flux. Molecular Pharmacology. 59: 1108-18. PMID 11306694  0.76
2001 Meddows E, Le Bourdellès B, Grimwood S, Wafford K, Sandhu S, Whiting P, McIlhinney RAJ. Identification of Molecular Determinants That Are Important in the Assembly of N-Methyl-D-aspartate Receptors Journal of Biological Chemistry. 276: 18795-18803. PMID 11279200 DOI: 10.1074/jbc.M101382200  0.76
2001 Maskell PD, Wafford KA, Bermudez I. Effects of gamma-HCH and delta-HCH on human recombinant GABA(A) receptors: dependence on GABA(A) receptor subunit combination. British Journal of Pharmacology. 132: 205-12. PMID 11156579 DOI: 10.1038/sj.bjp.0703824  0.76
2000 Dawson GR, Wafford KA, Smith A, Marshall GR, Bayley PJ, Schaeffer JM, Meinke PT, McKernan RM. Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor. The Journal of Pharmacology and Experimental Therapeutics. 295: 1051-60. PMID 11082440  0.76
2000 Collins I, Davey WB, Rowley M, Quirk K, Bromidge FA, McKernan RM, Thompson SA, Wafford KA. N-(indol-3-ylglyoxylyl)piperidines: high affinity agonists of human GABA-A receptors containing the alpha1 subunit. Bioorganic & Medicinal Chemistry Letters. 10: 1381-4. PMID 10890169 DOI: 10.1016/S0960-894X(00)00245-6  0.76
2000 McKernan RM, Rosahl TW, Reynolds DS, Sur C, Wafford KA, Atack JR, Farrar S, Myers J, Cook G, Ferris P, Garrett L, Bristow L, Marshall G, Macaulay A, Brown N, et al. Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype. Nature Neuroscience. 3: 587-92. PMID 10816315 DOI: 10.1038/75761  0.76
2000 Maksay G, Thompson SA, Wafford KA. Allosteric modulators affect the efficacy of partial agonists for recombinant GABA(A) receptors. British Journal of Pharmacology. 129: 1794-800. PMID 10780988 DOI: 10.1038/sj.bjp.0703259  0.76
1999 Thompson SA, Smith MZ, Wingrove PB, Whiting PJ, Wafford KA. Mutation at the putative GABA(A) ion-channel gate reveals changes in allosteric modulation. British Journal of Pharmacology. 127: 1349-58. PMID 10455284 DOI: 10.1038/sj.bjp.0702687  0.76
1999 Bonnert TP, McKernan RM, Farrar S, le Bourdellès B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Brown N, Wafford KA, Whiting PJ. theta, a novel gamma-aminobutyric acid type A receptor subunit. Proceedings of the National Academy of Sciences of the United States of America. 96: 9891-6. PMID 10449790 DOI: 10.1073/pnas.96.17.9891  0.76
1999 Whiting PJ, Bonnert TP, McKernan RM, Farrar S, Le Bourdellès B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Thompson SA, Wafford KA. Molecular and functional diversity of the expanding GABA-A receptor gene family. Annals of the New York Academy of Sciences. 868: 645-53. PMID 10414349 DOI: 10.1111/j.1749-6632.1999.tb11341.x  0.76
1999 Thompson SA, Arden SA, Marshall G, Wingrove PB, Whiting PJ, Wafford KA. Residues in transmembrane domains I and II determine gamma-aminobutyric acid type AA receptor subtype-selective antagonism by furosemide. Molecular Pharmacology. 55: 993-9. PMID 10347239  0.76
1998 Thompson SA, Bonnert TP, Whiting PJ, Wafford KA. Functional characteristics of recombinant human GABA(A) receptors containing the epsilon-subunit. Toxicology Letters. 100: 233-8. PMID 10049148 DOI: 10.1016/S0378-4274(98)00190-8  0.76
1997 Ebert B, Thompson SA, Saounatsou K, McKernan R, Krogsgaard-Larsen P, Wafford KA. Differences in agonist/antagonist binding affinity and receptor transduction using recombinant human gamma-aminobutyric acid type A receptors. Molecular Pharmacology. 52: 1150-6. PMID 9396785  0.76
1997 Whiting PJ, McAllister G, Bonnert T, Heavens RP, Rigby MR, Sirinathsinghji DJ, Marshall G, Thompson SA, Wafford KA. The use of expressed sequence tag databases to identify novel human gamma-aminobutyric acid type receptor genes. Biochemical Society Transactions. 25: 817-9. PMID 9388552  0.76
1997 Belelli D, Lambert JJ, Peters JA, Wafford K, Whiting PJ. The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid. Proceedings of the National Academy of Sciences of the United States of America. 94: 11031-6. PMID 9380754 DOI: 10.1073/pnas.94.20.11031  0.76
1997 Wingrove PB, Thompson SA, Wafford KA, Whiting PJ. Key amino acids in the gamma subunit of the gamma-aminobutyric acidA receptor that determine ligand binding and modulation at the benzodiazepine site. Molecular Pharmacology. 52: 874-81. PMID 9351978  0.76
1997 Aspinwall LS, Bermudez I, King LA, Wafford KA. The interactions of hexachlorocyclohexane isomers with human gamma-aminobutyric acid(A) receptors expressed in Xenopus oocytes. The Journal of Pharmacology and Experimental Therapeutics. 282: 1557-64. PMID 9316872  0.76
1997 Whiting PJ, McAllister G, Vassilatis D, Bonnert TP, Heavens RP, Smith DW, Hewson L, O'Donnell R, Rigby MR, Sirinathsinghji DJ, Marshall G, Thompson SA, Wafford KA, Vasilatis D. Neuronally restricted RNA splicing regulates the expression of a novel GABAA receptor subunit conferring atypical functional properties [corrected; erratum to be published]. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 5027-37. PMID 9185540  0.76
1997 Brehm L, Ebert B, Kristiansen U, Wafford KA, Kemp JA, Krogsgaard-Larsen P. Structure and pharmacology of 4,5,6,7-tetrahydroisothiazolo [5,4-c]pyridin-3-ol (Thio-THIP), an agonist/antagonist at GABA(A) receptors European Journal of Medicinal Chemistry. 32: 357-363. DOI: 10.1016/S0223-5234(97)89089-7  0.76
1996 Thompson SA, Whiting PJ, Wafford KA. Barbiturate interactions at the human GABAA receptor: dependence on receptor subunit combination. British Journal of Pharmacology. 117: 521-527. PMID 8821543  0.76
1996 Wafford KA, Thompson SA, Thomas D, Sikela J, Wilcox AS, Whiting PJ. Functional characterization of human gamma-aminobutyric acidA receptors containing the alpha 4 subunit. Molecular Pharmacology. 50: 670-8. PMID 8794909  0.76
1996 Hadingham KL, Garrett EM, Wafford KA, Bain C, Heavens RP, Sirinathsinghji DJ, Whiting PJ. Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors. Molecular Pharmacology. 49: 253-9. PMID 8632757  0.76
1995 Stevenson A, Wingrove PB, Whiting PJ, Wafford KA. beta-Carboline gamma-aminobutyric acidA receptor inverse agonists modulate gamma-aminobutyric acid via the loreclezole binding site as well as the benzodiazepine site. Molecular Pharmacology. 48: 965-9. PMID 8848011  0.76
1995 Hadingham KL, Wafford KA, Thompson SA, Palmer KJ, Whiting PJ. Expression and pharmacology of human GABAA receptors containing gamma 3 subunits. European Journal of Pharmacology. 291: 301-9. PMID 8719414 DOI: 10.1016/0922-4106(95)90070-5  0.76
1995 Whiting PJ, McKernan RM, Wafford KA. Structure and pharmacology of vertebrate GABAA receptor subtypes. International Review of Neurobiology. 38: 95-138. PMID 8537206  0.76
1995 Wafford KA, Kathoria M, Bain CJ, Marshall G, Le Bourdellès B, Kemp JA, Whiting PJ. Identification of amino acids in the N-methyl-D-aspartate receptor NR1 subunit that contribute to the glycine binding site. Molecular Pharmacology. 47: 374-80. PMID 7870047  0.76
1994 Le Bourdellès B, Wafford KA, Kemp JA, Marshall G, Bain C, Wilcox AS, Sikela JM, Whiting PJ. Cloning, functional coexpression, and pharmacological characterisation of human cDNAs encoding NMDA receptor NR1 and NR2A subunits. Journal of Neurochemistry. 62: 2091-8. PMID 8189218  0.76
1994 Wingrove PB, Wafford KA, Bain C, Whiting PJ. The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit. Proceedings of the National Academy of Sciences of the United States of America. 91: 4569-73. PMID 8183949  0.76
1994 Wafford KA, Bain CJ, Quirk K, McKernan RM, Wingrove PB, Whiting PJ, Kemp JA. A novel allosteric modulatory site on the GABAA receptor beta subunit. Neuron. 12: 775-82. PMID 8161449 DOI: 10.1016/0896-6273(94)90330-1  0.76
1994 Ebert B, Wafford KA, Whiting PJ, Krogsgaard-Larsen P, Kemp JA. Molecular pharmacology of gamma-aminobutyric acid type A receptor agonists and partial agonists in oocytes injected with different alpha, beta, and gamma receptor subunit combinations. Molecular Pharmacology. 46: 957-63. PMID 7969086  0.76
1994 Mihic SJ, Whiting PJ, Klein RL, Wafford KA, Harris RA. A single amino acid of the human gamma-aminobutyric acid type A receptor gamma 2 subunit determines benzodiazepine efficacy. The Journal of Biological Chemistry. 269: 32768-73. PMID 7806498  0.76
1993 Wafford KA, Whiting PJ, Kemp JA. Differences in affinity and efficacy of benzodiazepine receptor ligands at recombinant gamma-aminobutyric acidA receptor subtypes. Molecular Pharmacology. 43: 240-4. PMID 8381510  0.76
1993 Hadingham KL, Wingrove PB, Wafford KA, Bain C, Kemp JA, Palmer KJ, Wilson AW, Wilcox AS, Sikela JM, Ragan CI. Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors. Molecular Pharmacology. 44: 1211-8. PMID 8264558  0.76
1993 Wafford KA, Bain CJ, Whiting PJ, Kemp JA. Functional comparison of the role of gamma subunits in recombinant human gamma-aminobutyric acidA/benzodiazepine receptors. Molecular Pharmacology. 44: 437-42. PMID 8102787  0.76
1993 Wafford KA, Bain CJ, Le Bourdelles B, Whiting PJ, Kemp JA. Preferential co-assembly of recombinant NMDA receptors composed of three different subunits. Neuroreport. 4: 1347-9. PMID 7903167  0.76
1993 Wafford KA, Burnett D, Harris RA, Whiting PJ. GABAA receptor subunit expression and sensitivity to ethanol. Alcohol and Alcoholism (Oxford, Oxfordshire). Supplement. 2: 327-30. PMID 7748319  0.76
1993 Rauh JJ, Vassallo JG, Lummis SCR, Wafford KA, Sattelle DB. Steroids reveal differences between GABA-operated chloride channels of insects and vertebrates Molecular Neuropharmacology. 3: 1-9.  0.76
1992 Wafford KA, Whiting P, Kemp JA. Functional modulation of cloned GABAA receptors expressed in Xenopus oocytes. Advances in Biochemical Psychopharmacology. 47: 75-9. PMID 1354921  0.76
1992 Wafford KA, Bai D, Sattelle DB. A novel kainate receptor in the insect nervous system. Neuroscience Letters. 141: 273-6. PMID 1331899 DOI: 10.1016/0304-3940(92)90912-Q  0.76
1992 Wafford KA, Whiting PJ. Ethanol potentiation of GABAA receptors requires phosphorylation of the alternatively spliced variant of the gamma 2 subunit. Febs Letters. 313: 113-7. PMID 1330701 DOI: 10.1016/0014-5793(92)81424-K  0.76
1991 Wafford KA, Burnett DM, Leidenheimer NJ, Burt DR, Wang JB, Kofuji P, Dunwiddie TV, Harris RA, Sikela JM. Ethanol sensitivity of the GABAA receptor expressed in Xenopus oocytes requires 8 amino acids contained in the gamma 2L subunit. Neuron. 7: 27-33. PMID 1712603 DOI: 10.1016/0896-6273(91)90071-7  0.76
1990 Wafford KA, Burnett DM, Dunwiddie TV, Harris RA. Genetic differences in the ethanol sensitivity of GABAA receptors expressed in Xenopus oocytes. Science (New York, N.Y.). 249: 291-3. PMID 1695761  0.76
1989 Wafford KA, Dunwiddie TV, Harris RA. Calcium-dependent chloride currents elicited by injection of ethanol into Xenopus oocytes. Brain Research. 505: 215-9. PMID 2557132 DOI: 10.1016/0006-8993(89)91445-5  0.76
1989 Sattelle DB, Buckingham SD, Wafford KA, Sherby SM, Bakry NM, Eldefrawi AT, Eldefrawi ME, May TE. Actions of the insecticide 2(nitromethylene)tetrahydro-1,3-thiazine on insect and vertebrate nicotinic acetylcholine receptors. Proceedings of the Royal Society of London. Series B, Biological Sciences. 237: 501-14. PMID 2479949  0.76
1989 Wafford KA, Lummis SC, Sattelle DB. Block of an insect central nervous system GABA receptor by cyclodiene and cyclohexane insecticides. Proceedings of the Royal Society of London. Series B, Biological Sciences. 237: 53-61. PMID 2474166  0.76
1989 Wafford KA, Sattelle DB, Gant DB, Eldefrawi AT, Eldefrawi ME. Noncompetitive inhibition of GABA receptors in insect and vertebrate CNS by endrin and lindane Pesticide Biochemistry and Physiology. 33: 213-219. DOI: 10.1016/0048-3575(89)90119-3  0.76
1988 Sattelle DB, Pinnock RD, Wafford KA, David JA. GABA receptors on the cell-body membrane of an identified insect motor neuron. Proceedings of the Royal Society of London. Series B, Biological Sciences. 232: 443-56. PMID 2451252  0.76
1987 Wafford KA, Sattelle DB, Abalis I, Eldefrawi AT, Eldefrawi ME. gamma-Aminobutyric acid-activated 36Cl- influx: a functional in vitro assay for CNS gamma-aminobutyric acid receptors of insects. Journal of Neurochemistry. 48: 177-80. PMID 3025362 DOI: 10.1111/j.1471-4159.1987.tb13144.x  0.76
1987 Sherby SM, Eldefrawi ME, Wafford KA, Sattelle DB, Eldefrawi AT. Pharmacology of putative glutamate receptors from insect skeletal muscles, insect central nervous system and rat brain. Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology. 87: 99-106. PMID 2885148 DOI: 10.1016/0742-8413(87)90189-7  0.76
1986 Wafford KA, Sattelle DB. Effects of amino acid neurotransmitter candidates on an identified insect motoneurone. Neuroscience Letters. 63: 135-40. PMID 2869456 DOI: 10.1016/0304-3940(86)90050-9  0.76
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