Keith A. Wafford - Publications

Affiliations: 
Eli Lilly, Indianapolis, IN, United States 

98 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Kato AS, Burris KD, Gardinier KM, Gernert DL, Porter WJ, Reel J, Ding C, Tu Y, Schober DA, Lee MR, Heinz BA, Fitch TE, Gleason SD, Catlow JT, Yu H, ... ... Wafford KA, et al. Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism. Nature Medicine. PMID 27820603 DOI: 10.1038/Nm.4221  0.403
2013 Jensen ML, Wafford KA, Brown AR, Belelli D, Lambert JJ, Mirza NR. A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (DS2) at human recombinant and rodent native GABA(A) receptors. British Journal of Pharmacology. 168: 1118-32. PMID 23061935 DOI: 10.1111/Bph.12001  0.623
2013 Gilmour G, Broad LM, Wafford KA, Britton T, Colvin EM, Fivush A, Gastambide F, Getman B, Heinz BA, McCarthy AP, Prieto L, Shanks E, Smith JW, Taboada L, Edgar DM, et al. In vitro characterisation of the novel positive allosteric modulators of the mGluâ‚… receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat. Neuropharmacology. 64: 224-39. PMID 22884720 DOI: 10.1016/j.neuropharm.2012.07.030  0.349
2012 Mirza NR, Atack J, Wafford K. GABA(A) Receptor Subtypes: Novel Targets for Novel Medicines. Advances in Pharmacological Sciences. 2012: 529861. PMID 22570647 DOI: 10.1155/2012/529861  0.573
2012 Mirza NR, Atack J, Wafford K. GABA A receptor subtypes: Novel targets for novel medicines Advances in Pharmacological Sciences. 2012. DOI: 10.1155/2012/529861  0.573
2011 Atack JR, Hallett DJ, Tye S, Wafford KA, Ryan C, Sanabria-Bohórquez SM, Eng WS, Gibson RE, Burns HD, Dawson GR, Carling RW, Street LJ, Pike A, De Lepeleire I, Van Laere K, et al. Preclinical and clinical pharmacology of TPA023B, a GABAA receptor α2/α3 subtype-selective partial agonist. Journal of Psychopharmacology (Oxford, England). 25: 329-44. PMID 20156926 DOI: 10.1177/0269881109354928  0.475
2011 Atack JR, Wafford KA, Street LJ, Dawson GR, Tye S, Van Laere K, Bormans G, Sanabria-Bohórquez SM, De Lepeleire I, de Hoon JN, Van Hecken A, Burns HD, McKernan RM, Murphy MG, Hargreaves RJ. MRK-409 (MK-0343), a GABAA receptor subtype-selective partial agonist, is a non-sedating anxiolytic in preclinical species but causes sedation in humans. Journal of Psychopharmacology (Oxford, England). 25: 314-28. PMID 20147571 DOI: 10.1177/0269881109354927  0.358
2010 Mortensen M, Ebert B, Wafford K, Smart TG. Distinct activities of GABA agonists at synaptic- and extrasynaptic-type GABAA receptors. The Journal of Physiology. 588: 1251-68. PMID 20176630 DOI: 10.1113/Jphysiol.2009.182444  0.56
2009 Wafford KA, van Niel MB, Ma QP, Horridge E, Herd MB, Peden DR, Belelli D, Lambert JJ. Novel compounds selectively enhance delta subunit containing GABA A receptors and increase tonic currents in thalamus. Neuropharmacology. 56: 182-9. PMID 18762200 DOI: 10.1016/J.Neuropharm.2008.08.004  0.66
2008 Herd MB, Haythornthwaite AR, Rosahl TW, Wafford KA, Homanics GE, Lambert JJ, Belelli D. The expression of GABAA beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells. The Journal of Physiology. 586: 989-1004. PMID 18079158 DOI: 10.1113/Jphysiol.2007.146746  0.399
2008 Peden DR, Petitjean CM, Herd MB, Durakoglugil MS, Rosahl TW, Wafford K, Homanics GE, Belelli D, Fritschy JM, Lambert JJ. Developmental maturation of synaptic and extrasynaptic GABAA receptors in mouse thalamic ventrobasal neurones. The Journal of Physiology. 586: 965-87. PMID 18063661 DOI: 10.1113/Jphysiol.2007.145375  0.511
2007 Fradley RL, Guscott MR, Bull S, Hallett DJ, Goodacre SC, Wafford KA, Garrett EM, Newman RJ, O'Meara GF, Whiting PJ, Rosahl TW, Dawson GR, Reynolds DS, Atack JR. Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands. Journal of Psychopharmacology (Oxford, England). 21: 384-91. PMID 17092983 DOI: 10.1177/0269881106067255  0.328
2006 Groves JO, Guscott MR, Hallett DJ, Rosahl TW, Pike A, Davies A, Wafford KA, Reynolds DS. The role of GABAbeta2 subunit-containing receptors in mediating the anticonvulsant and sedative effects of loreclezole. The European Journal of Neuroscience. 24: 167-74. PMID 16882014 DOI: 10.1111/j.1460-9568.2006.04890.x  0.475
2006 Ebert B, Wafford KA, Deacon S. Treating insomnia: Current and investigational pharmacological approaches. Pharmacology & Therapeutics. 112: 612-29. PMID 16876255 DOI: 10.1016/j.pharmthera.2005.04.014  0.604
2006 Carling RW, Russell MG, Moore KW, Mitchinson A, Guiblin A, Smith A, Wafford KA, Marshall G, Atack JR, Street LJ. 2,3,7-Trisubstituted pyrazolo[1,5-d][1,2,4]triazines: functionally selective GABAA alpha3-subtype agonists. Bioorganic & Medicinal Chemistry Letters. 16: 3550-4. PMID 16621541 DOI: 10.1016/j.bmcl.2006.03.081  0.374
2006 Lewis RT, Blackaby WP, Blackburn T, Jennings AS, Pike A, Wilson RA, Hallett DJ, Cook SM, Ferris P, Marshall GR, Reynolds DS, Sheppard WF, Smith AJ, Sohal B, Stanley J, ... ... Wafford KA, et al. A pyridazine series of alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety. Journal of Medicinal Chemistry. 49: 2600-10. PMID 16610803 DOI: 10.1021/jm051144x  0.336
2006 Russell MG, Carling RW, Street LJ, Hallett DJ, Goodacre S, Mezzogori E, Reader M, Cook SM, Bromidge FA, Newman R, Smith AJ, Wafford KA, Marshall GR, Reynolds DS, Dias R, et al. Discovery of imidazo[1,2-b][1,2,4]triazines as GABA(A) alpha2/3 subtype selective agonists for the treatment of anxiety. Journal of Medicinal Chemistry. 49: 1235-8. PMID 16480260 DOI: 10.1021/jm051200u  0.448
2006 Atack JR, Pike A, Marshall G, Stanley J, Lincoln R, Cook SM, Lewis RT, Blackaby WP, Goodacre SC, McKernan RM, Dawson GR, Wafford KA, Reynolds DS. The in vivo properties of pagoclone in rat are most likely mediated by 5'-hydroxy pagoclone. Neuropharmacology. 50: 677-89. PMID 16430927 DOI: 10.1016/j.neuropharm.2005.11.014  0.315
2006 Blackaby WP, Atack JR, Bromidge F, Castro JL, Goodacre SC, Hallett DJ, Lewis RT, Marshall GR, Pike A, Smith AJ, Street LJ, Tattersall DF, Wafford KA. Imidazo[1,2-a]pyrimidines as functionally selective GABA(A) ligands. Bioorganic & Medicinal Chemistry Letters. 16: 1175-9. PMID 16406613 DOI: 10.1016/j.bmcl.2005.11.112  0.451
2006 Goodacre SC, Street LJ, Hallett DJ, Crawforth JM, Kelly S, Owens AP, Blackaby WP, Lewis RT, Stanley J, Smith AJ, Ferris P, Sohal B, Cook SM, Pike A, Brown N, ... Wafford KA, et al. Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABA(A)alpha2/alpha3 binding site agonists for the treatment of anxiety disorders. Journal of Medicinal Chemistry. 49: 35-8. PMID 16392789 DOI: 10.1021/jm051065l  0.401
2006 Jennings AS, Lewis RT, Russell MG, Hallett DJ, Street LJ, Castro JL, Atack JR, Cook SM, Lincoln R, Stanley J, Smith AJ, Reynolds DS, Sohal B, Pike A, Marshall GR, ... Wafford KA, et al. Imidazo[1,2-b][1,2,4]triazines as alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety. Bioorganic & Medicinal Chemistry Letters. 16: 1477-80. PMID 16386900 DOI: 10.1016/j.bmcl.2005.12.044  0.346
2006 Goodacre SC, Hallett DJ, Carling RW, Castro JL, Reynolds DS, Pike A, Wafford KA, Newman R, Atack JR, Street LJ. Imidazo[1,2-a]pyrazin-8-ones, imidazo[1,2-d][1,2,4]triazin-8-ones and imidazo[2,1-f][1,2,4]triazin-8-ones as alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety. Bioorganic & Medicinal Chemistry Letters. 16: 1582-5. PMID 16384707 DOI: 10.1016/j.bmcl.2005.12.027  0.396
2006 Wafford KA, Ebert B. Gaboxadol--a new awakening in sleep. Current Opinion in Pharmacology. 6: 30-6. PMID 16368265 DOI: 10.1016/j.coph.2005.10.004  0.538
2006 Dawson GR, Maubach KA, Collinson N, Cobain M, Everitt BJ, MacLeod AM, Choudhury HI, McDonald LM, Pillai G, Rycroft W, Smith AJ, Sternfeld F, Tattersall FD, Wafford KA, Reynolds DS, et al. An inverse agonist selective for alpha5 subunit-containing GABAA receptors enhances cognition. The Journal of Pharmacology and Experimental Therapeutics. 316: 1335-45. PMID 16326923 DOI: 10.1124/jpet.105.092320  0.385
2006 Jones P, Atack JR, Braun MP, Cato BP, Chambers MS, O'Connor D, Cook SM, Hobbs SC, Maxey R, Szekeres HJ, Szeto N, Wafford KA, MacLeod AM. Pharmacokinetics and metabolism studies on (3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally selective GABA(A) alpha5 inverse agonist for cognitive dysfunction. Bioorganic & Medicinal Chemistry Letters. 16: 872-5. PMID 16303300 DOI: 10.1016/j.bmcl.2005.11.012  0.35
2006 Borghese CM, Stórustovu Sí, Ebert B, Herd MB, Belelli D, Lambert JJ, Marshall G, Wafford KA, Harris RA. The delta subunit of gamma-aminobutyric acid type A receptors does not confer sensitivity to low concentrations of ethanol. The Journal of Pharmacology and Experimental Therapeutics. 316: 1360-8. PMID 16272217 DOI: 10.1124/Jpet.105.092452  0.528
2005 Belelli D, Peden DR, Rosahl TW, Wafford KA, Lambert JJ. Extrasynaptic GABAA receptors of thalamocortical neurons: a molecular target for hypnotics. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11513-20. PMID 16354909 DOI: 10.1523/Jneurosci.2679-05.2005  0.388
2005 Dias R, Sheppard WF, Fradley RL, Garrett EM, Stanley JL, Tye SJ, Goodacre S, Lincoln RJ, Cook SM, Conley R, Hallett D, Humphries AC, Thompson SA, Wafford KA, Street LJ, et al. Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10682-8. PMID 16291941 DOI: 10.1523/JNEUROSCI.1166-05.2005  0.434
2005 Carling RW, Madin A, Guiblin A, Russell MG, Moore KW, Mitchinson A, Sohal B, Pike A, Cook SM, Ragan IC, McKernan RM, Quirk K, Ferris P, Marshall G, Thompson SA, ... Wafford KA, et al. 7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine: a functionally selective gamma-aminobutyric acid(A) (GABA(A)) alpha2/alpha3-subtype selective agonist that exhibits potent anxiolytic activity but is not sedating in animal models. Journal of Medicinal Chemistry. 48: 7089-92. PMID 16279764 DOI: 10.1021/jm058034a  0.404
2005 Wafford KA. GABAA receptor subtypes: any clues to the mechanism of benzodiazepine dependence? Current Opinion in Pharmacology. 5: 47-52. PMID 15661625 DOI: 10.1016/j.coph.2004.08.006  0.445
2005 Atack JR, Hutson PH, Collinson N, Marshall G, Bentley G, Moyes C, Cook SM, Collins I, Wafford K, McKernan RM, Dawson GR. Anxiogenic properties of an inverse agonist selective for alpha3 subunit-containing GABA A receptors. British Journal of Pharmacology. 144: 357-66. PMID 15655523 DOI: 10.1038/Sj.Bjp.0706056  0.446
2005 Lambert JJ, Haythornthwaite AR, Peden DR, Herd MB, Wafford KA, Rosahl TW, Belelli D. The GABAA receptor: An important target for the general anaesthetic etomidate International Congress Series. 1283: 67-72. DOI: 10.1016/j.ics.2005.07.071  0.304
2004 Caraiscos VB, Newell JG, You-Ten KE, Elliott EM, Rosahl TW, Wafford KA, MacDonald JF, Orser BA. Selective enhancement of tonic GABAergic inhibition in murine hippocampal neurons by low concentrations of the volatile anesthetic isoflurane. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 8454-8. PMID 15456818 DOI: 10.1523/Jneurosci.2063-04.2004  0.543
2004 Street LJ, Sternfeld F, Jelley RA, Reeve AJ, Carling RW, Moore KW, McKernan RM, Sohal B, Cook S, Pike A, Dawson GR, Bromidge FA, Wafford KA, Seabrook GR, Thompson SA, et al. Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site. Journal of Medicinal Chemistry. 47: 3642-57. PMID 15214791 DOI: 10.1021/jm0407613  0.467
2004 Cirone J, Rosahl TW, Reynolds DS, Newman RJ, O'Meara GF, Hutson PH, Wafford KA. Gamma-aminobutyric acid type A receptor beta 2 subunit mediates the hypothermic effect of etomidate in mice. Anesthesiology. 100: 1438-45. PMID 15166563 DOI: 10.1097/00000542-200406000-00016  0.319
2004 Wafford KA, Macaulay AJ, Fradley R, O'Meara GF, Reynolds DS, Rosahl TW. Differentiating the role of gamma-aminobutyric acid type A (GABAA) receptor subtypes. Biochemical Society Transactions. 32: 553-6. PMID 15157182 DOI: 10.1042/BST0320553  0.435
2004 Connolly CN, Wafford KA. The Cys-loop superfamily of ligand-gated ion channels: the impact of receptor structure on function. Biochemical Society Transactions. 32: 529-34. PMID 15157178 DOI: 10.1042/BST0320529  0.301
2004 Thompson SA, Wheat L, Brown NA, Wingrove PB, Pillai GV, Whiting PJ, Adkins C, Woodward CH, Smith AJ, Simpson PB, Collins I, Wafford KA. Salicylidene salicylhydrazide, a selective inhibitor of beta 1-containing GABAA receptors. British Journal of Pharmacology. 142: 97-106. PMID 15100159 DOI: 10.1038/Sj.Bjp.0705689  0.529
2004 Sternfeld F, Carling RW, Jelley RA, Ladduwahetty T, Merchant KJ, Moore KW, Reeve AJ, Street LJ, O'Connor D, Sohal B, Atack JR, Cook S, Seabrook G, Wafford K, Tattersall FD, et al. Selective, orally active gamma-aminobutyric acidA alpha5 receptor inverse agonists as cognition enhancers. Journal of Medicinal Chemistry. 47: 2176-9. PMID 15084116 DOI: 10.1021/jm031076j  0.431
2004 Crawforth J, Atack JR, Cook SM, Gibson KR, Nadin A, Owens AP, Pike A, Rowley M, Smith AJ, Sohal B, Sternfeld F, Wafford K, Street LJ. Tricyclic pyridones as functionally selective human GABA Aα2/3 receptor-ion channel ligands Bioorganic and Medicinal Chemistry Letters. 14: 1679-1682. PMID 15026049 DOI: 10.1016/j.bmcl.2004.01.057  0.431
2004 Caraiscos VB, Elliott EM, You-Ten KE, Cheng VY, Belelli D, Newell JG, Jackson MF, Lambert JJ, Rosahl TW, Wafford KA, MacDonald JF, Orser BA. Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors. Proceedings of the National Academy of Sciences of the United States of America. 101: 3662-7. PMID 14993607 DOI: 10.1073/Pnas.0307231101  0.578
2004 McCabe C, Shaw D, Atack JR, Street LJ, Wafford KA, Dawson GR, Reynolds DS, Leslie JC. Subtype-selective GABAergic drugs facilitate extinction of mouse operant behaviour. Neuropharmacology. 46: 171-8. PMID 14680756 DOI: 10.1016/J.Neuropharm.2003.09.004  0.418
2003 Priestley CM, Williamson EM, Wafford KA, Sattelle DB. Thymol, a constituent of thyme essential oil, is a positive allosteric modulator of human GABA(A) receptors and a homo-oligomeric GABA receptor from Drosophila melanogaster. British Journal of Pharmacology. 140: 1363-72. PMID 14623762 DOI: 10.1038/sj.bjp.0705542  0.732
2003 Usala M, Thompson SA, Whiting PJ, Wafford KA. Activity of chlormethiazole at human recombinant GABA(A) and NMDA receptors. British Journal of Pharmacology. 140: 1045-50. PMID 14530209 DOI: 10.1038/sj.bjp.0705540  0.503
2003 Reynolds DS, Rosahl TW, Cirone J, O'Meara GF, Haythornthwaite A, Newman RJ, Myers J, Sur C, Howell O, Rutter AR, Atack J, Macaulay AJ, Hadingham KL, Hutson PH, Belelli D, ... ... Wafford KA, et al. Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8608-17. PMID 13679430 DOI: 10.1523/Jneurosci.23-24-08608.2003  0.4
2003 Mortensen M, Wafford KA, Wingrove P, Ebert B. Pharmacology of GABA(A) receptors exhibiting different levels of spontaneous activity. European Journal of Pharmacology. 476: 17-24. PMID 12969744 DOI: 10.1016/S0014-2999(03)02125-3  0.628
2003 Maksay G, Thompson SA, Wafford KA. The pharmacology of spontaneously open alpha 1 beta 3 epsilon GABA A receptor-ionophores. Neuropharmacology. 44: 994-1002. PMID 12763092 DOI: 10.1016/S0028-3908(03)00116-3  0.514
2002 Thompson SA, Bonnert TP, Cagetti E, Whiting PJ, Wafford KA. Overexpression of the GABA(A) receptor epsilon subunit results in insensitivity to anaesthetics. Neuropharmacology. 43: 662-8. PMID 12367611 DOI: 10.1016/S0028-3908(02)00162-4  0.42
2002 Grimwood S, Wafford KA, Macaulay A, Hutson PH. N-Methyl-D-aspartate receptor subtype-selectivity of homoquinolinate: an electrophysiological and radioligand binding study using both native and recombinant receptors. Journal of Neurochemistry. 82: 794-800. PMID 12358784 DOI: 10.1046/j.1471-4159.2002.01014.x  0.338
2002 Brown N, Kerby J, Bonnert TP, Whiting PJ, Wafford KA. Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors. British Journal of Pharmacology. 136: 965-74. PMID 12145096 DOI: 10.1038/sj.bjp.0704795  0.381
2002 Collins I, Moyes C, Davey WB, Rowley M, Bromidge FA, Quirk K, Atack JR, McKernan RM, Thompson SA, Wafford K, Dawson GR, Pike A, Sohal B, Tsou NN, Ball RG, et al. 3-Heteroaryl-2-pyridones: benzodiazepine site ligands with functional delectivity for alpha 2/alpha 3-subtypes of human GABA(A) receptor-ion channels. Journal of Medicinal Chemistry. 45: 1887-900. PMID 11960500 DOI: 10.1021/Jm0110789  0.375
2002 Thompson SA, Wingrove PB, Connelly L, Whiting PJ, Wafford KA. Tracazolate reveals a novel type of allosteric interaction with recombinant gamma-aminobutyric acid(A) receptors. Molecular Pharmacology. 61: 861-9. PMID 11901225 DOI: 10.1124/mol.61.4.861  0.625
2002 Chambers MS, Atack JR, Bromidge FA, Broughton HB, Cook S, Dawson GR, Hobbs SC, Maubach KA, Reeve AJ, Seabrook GR, Wafford K, Ma AM. 6,7-Dihydro-2-benzothiophen-4(5H)-ones: A novel class of GABA-A α5 receptor inverse agonists Journal of Medicinal Chemistry. 45: 1176-1179. PMID 11881985 DOI: 10.1021/jm010471b  0.55
2002 Wingrove PB, Safo P, Wheat L, Thompson SA, Wafford KA, Whiting PJ. Mechanism of alpha-subunit selectivity of benzodiazepine pharmacology at gamma-aminobutyric acid type A receptors. European Journal of Pharmacology. 437: 31-9. PMID 11864636 DOI: 10.1016/S0014-2999(02)01279-7  0.438
2001 Ebert B, Mortensen M, Thompson SA, Kehler J, Wafford KA, Krogsgaard-Larsen P. Bioisosteric determinants for subtype selectivity of ligands for heteromeric GABA(A) receptors. Bioorganic & Medicinal Chemistry Letters. 11: 1573-7. PMID 11412984 DOI: 10.1016/S0960-894X(01)00184-6  0.631
2001 Sur C, Wafford KA, Reynolds DS, Hadingham KL, Bromidge F, Macaulay A, Collinson N, O'Meara G, Howell O, Newman R, Myers J, Atack JR, Dawson GR, McKernan RM, Whiting PJ, et al. Loss of the major GABA(A) receptor subtype in the brain is not lethal in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 3409-18. PMID 11331371  0.429
2001 Maskell PD, Wafford KA, Bermudez I. Effects of gamma-HCH and delta-HCH on human recombinant GABA(A) receptors: dependence on GABA(A) receptor subunit combination. British Journal of Pharmacology. 132: 205-12. PMID 11156579 DOI: 10.1038/sj.bjp.0703824  0.591
2000 Dawson GR, Wafford KA, Smith A, Marshall GR, Bayley PJ, Schaeffer JM, Meinke PT, McKernan RM. Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor. The Journal of Pharmacology and Experimental Therapeutics. 295: 1051-60. PMID 11082440  0.615
2000 Collins I, Davey WB, Rowley M, Quirk K, Bromidge FA, McKernan RM, Thompson SA, Wafford KA. N-(indol-3-ylglyoxylyl)piperidines: high affinity agonists of human GABA-A receptors containing the alpha1 subunit. Bioorganic & Medicinal Chemistry Letters. 10: 1381-4. PMID 10890169 DOI: 10.1016/S0960-894X(00)00245-6  0.463
2000 McKernan RM, Rosahl TW, Reynolds DS, Sur C, Wafford KA, Atack JR, Farrar S, Myers J, Cook G, Ferris P, Garrett L, Bristow L, Marshall G, Macaulay A, Brown N, et al. Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype. Nature Neuroscience. 3: 587-92. PMID 10816315 DOI: 10.1038/75761  0.6
2000 Maksay G, Thompson SA, Wafford KA. Allosteric modulators affect the efficacy of partial agonists for recombinant GABA(A) receptors. British Journal of Pharmacology. 129: 1794-800. PMID 10780988 DOI: 10.1038/sj.bjp.0703259  0.58
1999 Thompson SA, Smith MZ, Wingrove PB, Whiting PJ, Wafford KA. Mutation at the putative GABA(A) ion-channel gate reveals changes in allosteric modulation. British Journal of Pharmacology. 127: 1349-58. PMID 10455284 DOI: 10.1038/sj.bjp.0702687  0.644
1999 Bonnert TP, McKernan RM, Farrar S, le Bourdellès B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Brown N, Wafford KA, Whiting PJ. theta, a novel gamma-aminobutyric acid type A receptor subunit. Proceedings of the National Academy of Sciences of the United States of America. 96: 9891-6. PMID 10449790 DOI: 10.1073/pnas.96.17.9891  0.474
1999 Whiting PJ, Bonnert TP, McKernan RM, Farrar S, Le Bourdellès B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Thompson SA, Wafford KA. Molecular and functional diversity of the expanding GABA-A receptor gene family. Annals of the New York Academy of Sciences. 868: 645-53. PMID 10414349 DOI: 10.1111/j.1749-6632.1999.tb11341.x  0.583
1999 Thompson SA, Arden SA, Marshall G, Wingrove PB, Whiting PJ, Wafford KA. Residues in transmembrane domains I and II determine gamma-aminobutyric acid type AA receptor subtype-selective antagonism by furosemide. Molecular Pharmacology. 55: 993-9. PMID 10347239  0.517
1998 Thompson SA, Bonnert TP, Whiting PJ, Wafford KA. Functional characteristics of recombinant human GABA(A) receptors containing the epsilon-subunit. Toxicology Letters. 100: 233-8. PMID 10049148 DOI: 10.1016/S0378-4274(98)00190-8  0.617
1997 Ebert B, Thompson SA, Saounatsou K, McKernan R, Krogsgaard-Larsen P, Wafford KA. Differences in agonist/antagonist binding affinity and receptor transduction using recombinant human gamma-aminobutyric acid type A receptors. Molecular Pharmacology. 52: 1150-6. PMID 9396785  0.468
1997 Belelli D, Lambert JJ, Peters JA, Wafford K, Whiting PJ. The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid. Proceedings of the National Academy of Sciences of the United States of America. 94: 11031-6. PMID 9380754 DOI: 10.1073/Pnas.94.20.11031  0.408
1997 Wingrove PB, Thompson SA, Wafford KA, Whiting PJ. Key amino acids in the gamma subunit of the gamma-aminobutyric acidA receptor that determine ligand binding and modulation at the benzodiazepine site. Molecular Pharmacology. 52: 874-81. PMID 9351978  0.37
1997 Aspinwall LS, Bermudez I, King LA, Wafford KA. The interactions of hexachlorocyclohexane isomers with human gamma-aminobutyric acid(A) receptors expressed in Xenopus oocytes. The Journal of Pharmacology and Experimental Therapeutics. 282: 1557-64. PMID 9316872  0.611
1997 Whiting PJ, McAllister G, Vassilatis D, Bonnert TP, Heavens RP, Smith DW, Hewson L, O'Donnell R, Rigby MR, Sirinathsinghji DJ, Marshall G, Thompson SA, Wafford KA, Vasilatis D. Neuronally restricted RNA splicing regulates the expression of a novel GABAA receptor subunit conferring atypical functional properties [corrected; erratum to be published]. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 5027-37. PMID 9185540  0.464
1997 Brehm L, Ebert B, Kristiansen U, Wafford KA, Kemp JA, Krogsgaard-Larsen P. Structure and pharmacology of 4,5,6,7-tetrahydroisothiazolo [5,4-c]pyridin-3-ol (Thio-THIP), an agonist/antagonist at GABA(A) receptors European Journal of Medicinal Chemistry. 32: 357-363. DOI: 10.1016/S0223-5234(97)89089-7  0.49
1996 Thompson SA, Whiting PJ, Wafford KA. Barbiturate interactions at the human GABAA receptor: dependence on receptor subunit combination. British Journal of Pharmacology. 117: 521-527. PMID 8821543  0.407
1996 Wafford KA, Thompson SA, Thomas D, Sikela J, Wilcox AS, Whiting PJ. Functional characterization of human gamma-aminobutyric acidA receptors containing the alpha 4 subunit. Molecular Pharmacology. 50: 670-8. PMID 8794909  0.339
1996 Hadingham KL, Garrett EM, Wafford KA, Bain C, Heavens RP, Sirinathsinghji DJ, Whiting PJ. Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors. Molecular Pharmacology. 49: 253-9. PMID 8632757  0.42
1995 Mckernan RM, Wafford K, Quirk K, Hadingham KL, Harley EA, Ragan CI, Whiting PJ. The pharmacology of the benzodiazepine site of the GABA-a receptor is dependent on the type of γsubunit present Journal of Receptors and Signal Transduction. 15: 173-183. PMID 8903939 DOI: 10.3109/10799899509045215  0.565
1995 Hadingham KL, Wafford KA, Thompson SA, Palmer KJ, Whiting PJ. Expression and pharmacology of human GABAA receptors containing gamma 3 subunits. European Journal of Pharmacology. 291: 301-9. PMID 8719414 DOI: 10.1016/0922-4106(95)90070-5  0.302
1995 Wafford KA, Kathoria M, Bain CJ, Marshall G, Le Bourdellès B, Kemp JA, Whiting PJ. Identification of amino acids in the N-methyl-D-aspartate receptor NR1 subunit that contribute to the glycine binding site. Molecular Pharmacology. 47: 374-80. PMID 7870047  0.366
1994 Wafford KA, Bain CJ, Quirk K, McKernan RM, Wingrove PB, Whiting PJ, Kemp JA. A novel allosteric modulatory site on the GABAA receptor beta subunit. Neuron. 12: 775-82. PMID 8161449 DOI: 10.1016/0896-6273(94)90330-1  0.432
1994 Ebert B, Wafford KA, Whiting PJ, Krogsgaard-Larsen P, Kemp JA. Molecular pharmacology of gamma-aminobutyric acid type A receptor agonists and partial agonists in oocytes injected with different alpha, beta, and gamma receptor subunit combinations. Molecular Pharmacology. 46: 957-63. PMID 7969086  0.363
1994 Mihic SJ, Whiting PJ, Klein RL, Wafford KA, Harris RA. A single amino acid of the human gamma-aminobutyric acid type A receptor gamma 2 subunit determines benzodiazepine efficacy. The Journal of Biological Chemistry. 269: 32768-73. PMID 7806498  0.588
1993 Wafford KA, Whiting PJ, Kemp JA. Differences in affinity and efficacy of benzodiazepine receptor ligands at recombinant gamma-aminobutyric acidA receptor subtypes. Molecular Pharmacology. 43: 240-4. PMID 8381510  0.386
1993 Hadingham KL, Wingrove PB, Wafford KA, Bain C, Kemp JA, Palmer KJ, Wilson AW, Wilcox AS, Sikela JM, Ragan CI. Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors. Molecular Pharmacology. 44: 1211-8. PMID 8264558  0.329
1993 Wafford KA, Bain CJ, Whiting PJ, Kemp JA. Functional comparison of the role of gamma subunits in recombinant human gamma-aminobutyric acidA/benzodiazepine receptors. Molecular Pharmacology. 44: 437-42. PMID 8102787  0.344
1993 Wafford KA, Bain CJ, Le Bourdelles B, Whiting PJ, Kemp JA. Preferential co-assembly of recombinant NMDA receptors composed of three different subunits. Neuroreport. 4: 1347-9. PMID 7903167  0.312
1993 Wafford KA, Burnett D, Harris RA, Whiting PJ. GABAA receptor subunit expression and sensitivity to ethanol. Alcohol and Alcoholism (Oxford, Oxfordshire). Supplement. 2: 327-30. PMID 7748319  0.45
1993 Rauh JJ, Vassallo JG, Lummis SCR, Wafford KA, Sattelle DB. Steroids reveal differences between GABA-operated chloride channels of insects and vertebrates Molecular Neuropharmacology. 3: 1-9.  0.599
1992 Wafford KA, Whiting P, Kemp JA. Functional modulation of cloned GABAA receptors expressed in Xenopus oocytes. Advances in Biochemical Psychopharmacology. 47: 75-9. PMID 1354921  0.322
1992 Wafford KA, Bai D, Sattelle DB. A novel kainate receptor in the insect nervous system. Neuroscience Letters. 141: 273-6. PMID 1331899 DOI: 10.1016/0304-3940(92)90912-Q  0.586
1992 Wingrove P, Hadingham K, Wafford K, Kemp JA, Ragan CI, Whiting P. Cloning and expression of a cDNA encoding the human GABA-A receptor α5 subunit Biochemical Society Transactions. 20. PMID 1321750 DOI: 10.1042/BST020018S  0.499
1991 Wafford KA, Burnett DM, Leidenheimer NJ, Burt DR, Wang JB, Kofuji P, Dunwiddie TV, Harris RA, Sikela JM. Ethanol sensitivity of the GABAA receptor expressed in Xenopus oocytes requires 8 amino acids contained in the gamma 2L subunit. Neuron. 7: 27-33. PMID 1712603 DOI: 10.1016/0896-6273(91)90071-7  0.429
1989 Sattelle DB, Buckingham SD, Wafford KA, Sherby SM, Bakry NM, Eldefrawi AT, Eldefrawi ME, May TE. Actions of the insecticide 2(nitromethylene)tetrahydro-1,3-thiazine on insect and vertebrate nicotinic acetylcholine receptors. Proceedings of the Royal Society of London. Series B, Biological Sciences. 237: 501-14. PMID 2479949 DOI: 10.1098/Rspb.1989.0062  0.581
1989 Wafford KA, Lummis SC, Sattelle DB. Block of an insect central nervous system GABA receptor by cyclodiene and cyclohexane insecticides. Proceedings of the Royal Society of London. Series B, Biological Sciences. 237: 53-61. PMID 2474166 DOI: 10.1098/Rspb.1989.0036  0.733
1989 Wafford KA, Sattelle DB, Gant DB, Eldefrawi AT, Eldefrawi ME. Noncompetitive inhibition of GABA receptors in insect and vertebrate CNS by endrin and lindane Pesticide Biochemistry and Physiology. 33: 213-219. DOI: 10.1016/0048-3575(89)90119-3  0.747
1988 Sattelle DB, Pinnock RD, Wafford KA, David JA. GABA receptors on the cell-body membrane of an identified insect motor neuron. Proceedings of the Royal Society of London. Series B, Biological Sciences. 232: 443-56. PMID 2451252 DOI: 10.1098/Rspb.1988.0006  0.653
1987 Wafford KA, Sattelle DB, Abalis I, Eldefrawi AT, Eldefrawi ME. gamma-Aminobutyric acid-activated 36Cl- influx: a functional in vitro assay for CNS gamma-aminobutyric acid receptors of insects. Journal of Neurochemistry. 48: 177-80. PMID 3025362 DOI: 10.1111/j.1471-4159.1987.tb13144.x  0.695
1987 Sherby SM, Eldefrawi ME, Wafford KA, Sattelle DB, Eldefrawi AT. Pharmacology of putative glutamate receptors from insect skeletal muscles, insect central nervous system and rat brain. Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology. 87: 99-106. PMID 2885148 DOI: 10.1016/0742-8413(87)90189-7  0.45
1986 Wafford KA, Sattelle DB. Effects of amino acid neurotransmitter candidates on an identified insect motoneurone. Neuroscience Letters. 63: 135-40. PMID 2869456 DOI: 10.1016/0304-3940(86)90050-9  0.606
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