| Year |
Citation |
Score |
| 2016 |
Kato AS, Burris KD, Gardinier KM, Gernert DL, Porter WJ, Reel J, Ding C, Tu Y, Schober DA, Lee MR, Heinz BA, Fitch TE, Gleason SD, Catlow JT, Yu H, ... ... Wafford KA, et al. Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism. Nature Medicine. PMID 27820603 DOI: 10.1038/Nm.4221 |
0.407 |
|
| 2013 |
Jensen ML, Wafford KA, Brown AR, Belelli D, Lambert JJ, Mirza NR. A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (DS2) at human recombinant and rodent native GABA(A) receptors. British Journal of Pharmacology. 168: 1118-32. PMID 23061935 DOI: 10.1111/Bph.12001 |
0.625 |
|
| 2013 |
Gilmour G, Broad LM, Wafford KA, Britton T, Colvin EM, Fivush A, Gastambide F, Getman B, Heinz BA, McCarthy AP, Prieto L, Shanks E, Smith JW, Taboada L, Edgar DM, et al. In vitro characterisation of the novel positive allosteric modulators of the mGluâ‚… receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat. Neuropharmacology. 64: 224-39. PMID 22884720 DOI: 10.1016/j.neuropharm.2012.07.030 |
0.352 |
|
| 2012 |
Mirza NR, Atack J, Wafford K. GABA(A) Receptor Subtypes: Novel Targets for Novel Medicines. Advances in Pharmacological Sciences. 2012: 529861. PMID 22570647 DOI: 10.1155/2012/529861 |
0.574 |
|
| 2012 |
Mirza NR, Atack J, Wafford K. GABA A receptor subtypes: Novel targets for novel medicines Advances in Pharmacological Sciences. 2012. DOI: 10.1155/2012/529861 |
0.574 |
|
| 2011 |
Atack JR, Hallett DJ, Tye S, Wafford KA, Ryan C, Sanabria-Bohórquez SM, Eng WS, Gibson RE, Burns HD, Dawson GR, Carling RW, Street LJ, Pike A, De Lepeleire I, Van Laere K, et al. Preclinical and clinical pharmacology of TPA023B, a GABAA receptor α2/α3 subtype-selective partial agonist. Journal of Psychopharmacology (Oxford, England). 25: 329-44. PMID 20156926 DOI: 10.1177/0269881109354928 |
0.477 |
|
| 2011 |
Atack JR, Wafford KA, Street LJ, Dawson GR, Tye S, Van Laere K, Bormans G, Sanabria-Bohórquez SM, De Lepeleire I, de Hoon JN, Van Hecken A, Burns HD, McKernan RM, Murphy MG, Hargreaves RJ. MRK-409 (MK-0343), a GABAA receptor subtype-selective partial agonist, is a non-sedating anxiolytic in preclinical species but causes sedation in humans. Journal of Psychopharmacology (Oxford, England). 25: 314-28. PMID 20147571 DOI: 10.1177/0269881109354927 |
0.359 |
|
| 2010 |
Mortensen M, Ebert B, Wafford K, Smart TG. Distinct activities of GABA agonists at synaptic- and extrasynaptic-type GABAA receptors. The Journal of Physiology. 588: 1251-68. PMID 20176630 DOI: 10.1113/Jphysiol.2009.182444 |
0.564 |
|
| 2009 |
Wafford KA, van Niel MB, Ma QP, Horridge E, Herd MB, Peden DR, Belelli D, Lambert JJ. Novel compounds selectively enhance delta subunit containing GABA A receptors and increase tonic currents in thalamus. Neuropharmacology. 56: 182-9. PMID 18762200 DOI: 10.1016/J.Neuropharm.2008.08.004 |
0.662 |
|
| 2008 |
Herd MB, Haythornthwaite AR, Rosahl TW, Wafford KA, Homanics GE, Lambert JJ, Belelli D. The expression of GABAA beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells. The Journal of Physiology. 586: 989-1004. PMID 18079158 DOI: 10.1113/Jphysiol.2007.146746 |
0.402 |
|
| 2008 |
Peden DR, Petitjean CM, Herd MB, Durakoglugil MS, Rosahl TW, Wafford K, Homanics GE, Belelli D, Fritschy JM, Lambert JJ. Developmental maturation of synaptic and extrasynaptic GABAA receptors in mouse thalamic ventrobasal neurones. The Journal of Physiology. 586: 965-87. PMID 18063661 DOI: 10.1113/Jphysiol.2007.145375 |
0.513 |
|
| 2007 |
Fradley RL, Guscott MR, Bull S, Hallett DJ, Goodacre SC, Wafford KA, Garrett EM, Newman RJ, O'Meara GF, Whiting PJ, Rosahl TW, Dawson GR, Reynolds DS, Atack JR. Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands. Journal of Psychopharmacology (Oxford, England). 21: 384-91. PMID 17092983 DOI: 10.1177/0269881106067255 |
0.329 |
|
| 2006 |
Groves JO, Guscott MR, Hallett DJ, Rosahl TW, Pike A, Davies A, Wafford KA, Reynolds DS. The role of GABAbeta2 subunit-containing receptors in mediating the anticonvulsant and sedative effects of loreclezole. The European Journal of Neuroscience. 24: 167-74. PMID 16882014 DOI: 10.1111/j.1460-9568.2006.04890.x |
0.477 |
|
| 2006 |
Ebert B, Wafford KA, Deacon S. Treating insomnia: Current and investigational pharmacological approaches. Pharmacology & Therapeutics. 112: 612-29. PMID 16876255 DOI: 10.1016/j.pharmthera.2005.04.014 |
0.608 |
|
| 2006 |
Carling RW, Russell MG, Moore KW, Mitchinson A, Guiblin A, Smith A, Wafford KA, Marshall G, Atack JR, Street LJ. 2,3,7-Trisubstituted pyrazolo[1,5-d][1,2,4]triazines: functionally selective GABAA alpha3-subtype agonists. Bioorganic & Medicinal Chemistry Letters. 16: 3550-4. PMID 16621541 DOI: 10.1016/j.bmcl.2006.03.081 |
0.377 |
|
| 2006 |
Lewis RT, Blackaby WP, Blackburn T, Jennings AS, Pike A, Wilson RA, Hallett DJ, Cook SM, Ferris P, Marshall GR, Reynolds DS, Sheppard WF, Smith AJ, Sohal B, Stanley J, ... ... Wafford KA, et al. A pyridazine series of alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety. Journal of Medicinal Chemistry. 49: 2600-10. PMID 16610803 DOI: 10.1021/jm051144x |
0.337 |
|
| 2006 |
Russell MG, Carling RW, Street LJ, Hallett DJ, Goodacre S, Mezzogori E, Reader M, Cook SM, Bromidge FA, Newman R, Smith AJ, Wafford KA, Marshall GR, Reynolds DS, Dias R, et al. Discovery of imidazo[1,2-b][1,2,4]triazines as GABA(A) alpha2/3 subtype selective agonists for the treatment of anxiety. Journal of Medicinal Chemistry. 49: 1235-8. PMID 16480260 DOI: 10.1021/jm051200u |
0.45 |
|
| 2006 |
Atack JR, Pike A, Marshall G, Stanley J, Lincoln R, Cook SM, Lewis RT, Blackaby WP, Goodacre SC, McKernan RM, Dawson GR, Wafford KA, Reynolds DS. The in vivo properties of pagoclone in rat are most likely mediated by 5'-hydroxy pagoclone. Neuropharmacology. 50: 677-89. PMID 16430927 DOI: 10.1016/j.neuropharm.2005.11.014 |
0.316 |
|
| 2006 |
Blackaby WP, Atack JR, Bromidge F, Castro JL, Goodacre SC, Hallett DJ, Lewis RT, Marshall GR, Pike A, Smith AJ, Street LJ, Tattersall DF, Wafford KA. Imidazo[1,2-a]pyrimidines as functionally selective GABA(A) ligands. Bioorganic & Medicinal Chemistry Letters. 16: 1175-9. PMID 16406613 DOI: 10.1016/j.bmcl.2005.11.112 |
0.453 |
|
| 2006 |
Goodacre SC, Street LJ, Hallett DJ, Crawforth JM, Kelly S, Owens AP, Blackaby WP, Lewis RT, Stanley J, Smith AJ, Ferris P, Sohal B, Cook SM, Pike A, Brown N, ... Wafford KA, et al. Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABA(A)alpha2/alpha3 binding site agonists for the treatment of anxiety disorders. Journal of Medicinal Chemistry. 49: 35-8. PMID 16392789 DOI: 10.1021/jm051065l |
0.401 |
|
| 2006 |
Jennings AS, Lewis RT, Russell MG, Hallett DJ, Street LJ, Castro JL, Atack JR, Cook SM, Lincoln R, Stanley J, Smith AJ, Reynolds DS, Sohal B, Pike A, Marshall GR, ... Wafford KA, et al. Imidazo[1,2-b][1,2,4]triazines as alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety. Bioorganic & Medicinal Chemistry Letters. 16: 1477-80. PMID 16386900 DOI: 10.1016/j.bmcl.2005.12.044 |
0.347 |
|
| 2006 |
Goodacre SC, Hallett DJ, Carling RW, Castro JL, Reynolds DS, Pike A, Wafford KA, Newman R, Atack JR, Street LJ. Imidazo[1,2-a]pyrazin-8-ones, imidazo[1,2-d][1,2,4]triazin-8-ones and imidazo[2,1-f][1,2,4]triazin-8-ones as alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety. Bioorganic & Medicinal Chemistry Letters. 16: 1582-5. PMID 16384707 DOI: 10.1016/j.bmcl.2005.12.027 |
0.396 |
|
| 2006 |
Wafford KA, Ebert B. Gaboxadol--a new awakening in sleep. Current Opinion in Pharmacology. 6: 30-6. PMID 16368265 DOI: 10.1016/j.coph.2005.10.004 |
0.541 |
|
| 2006 |
Dawson GR, Maubach KA, Collinson N, Cobain M, Everitt BJ, MacLeod AM, Choudhury HI, McDonald LM, Pillai G, Rycroft W, Smith AJ, Sternfeld F, Tattersall FD, Wafford KA, Reynolds DS, et al. An inverse agonist selective for alpha5 subunit-containing GABAA receptors enhances cognition. The Journal of Pharmacology and Experimental Therapeutics. 316: 1335-45. PMID 16326923 DOI: 10.1124/jpet.105.092320 |
0.387 |
|
| 2006 |
Jones P, Atack JR, Braun MP, Cato BP, Chambers MS, O'Connor D, Cook SM, Hobbs SC, Maxey R, Szekeres HJ, Szeto N, Wafford KA, MacLeod AM. Pharmacokinetics and metabolism studies on (3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally selective GABA(A) alpha5 inverse agonist for cognitive dysfunction. Bioorganic & Medicinal Chemistry Letters. 16: 872-5. PMID 16303300 DOI: 10.1016/j.bmcl.2005.11.012 |
0.351 |
|
| 2006 |
Borghese CM, Stórustovu SÃ, Ebert B, Herd MB, Belelli D, Lambert JJ, Marshall G, Wafford KA, Harris RA. The delta subunit of gamma-aminobutyric acid type A receptors does not confer sensitivity to low concentrations of ethanol. The Journal of Pharmacology and Experimental Therapeutics. 316: 1360-8. PMID 16272217 DOI: 10.1124/Jpet.105.092452 |
0.528 |
|
| 2006 |
Ebert B, Wafford KA. Benzodiazepine receptor agonists and insomnia: Is subtype selectivity lost in translation? Drug Discovery Today: Therapeutic Strategies. 3: 547-554. DOI: 10.1016/j.ddstr.2006.11.008 |
0.385 |
|
| 2005 |
Belelli D, Peden DR, Rosahl TW, Wafford KA, Lambert JJ. Extrasynaptic GABAA receptors of thalamocortical neurons: a molecular target for hypnotics. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11513-20. PMID 16354909 DOI: 10.1523/Jneurosci.2679-05.2005 |
0.39 |
|
| 2005 |
Dias R, Sheppard WF, Fradley RL, Garrett EM, Stanley JL, Tye SJ, Goodacre S, Lincoln RJ, Cook SM, Conley R, Hallett D, Humphries AC, Thompson SA, Wafford KA, Street LJ, et al. Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10682-8. PMID 16291941 DOI: 10.1523/JNEUROSCI.1166-05.2005 |
0.436 |
|
| 2005 |
Carling RW, Madin A, Guiblin A, Russell MG, Moore KW, Mitchinson A, Sohal B, Pike A, Cook SM, Ragan IC, McKernan RM, Quirk K, Ferris P, Marshall G, Thompson SA, ... Wafford KA, et al. 7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine: a functionally selective gamma-aminobutyric acid(A) (GABA(A)) alpha2/alpha3-subtype selective agonist that exhibits potent anxiolytic activity but is not sedating in animal models. Journal of Medicinal Chemistry. 48: 7089-92. PMID 16279764 DOI: 10.1021/jm058034a |
0.405 |
|
| 2005 |
Wafford KA. GABAA receptor subtypes: any clues to the mechanism of benzodiazepine dependence? Current Opinion in Pharmacology. 5: 47-52. PMID 15661625 DOI: 10.1016/j.coph.2004.08.006 |
0.447 |
|
| 2005 |
Atack JR, Hutson PH, Collinson N, Marshall G, Bentley G, Moyes C, Cook SM, Collins I, Wafford K, McKernan RM, Dawson GR. Anxiogenic properties of an inverse agonist selective for alpha3 subunit-containing GABA A receptors. British Journal of Pharmacology. 144: 357-66. PMID 15655523 DOI: 10.1038/Sj.Bjp.0706056 |
0.448 |
|
| 2005 |
Lambert JJ, Haythornthwaite AR, Peden DR, Herd MB, Wafford KA, Rosahl TW, Belelli D. The GABAA receptor: An important target for the general anaesthetic etomidate International Congress Series. 1283: 67-72. DOI: 10.1016/j.ics.2005.07.071 |
0.306 |
|
| 2004 |
Caraiscos VB, Newell JG, You-Ten KE, Elliott EM, Rosahl TW, Wafford KA, MacDonald JF, Orser BA. Selective enhancement of tonic GABAergic inhibition in murine hippocampal neurons by low concentrations of the volatile anesthetic isoflurane. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 8454-8. PMID 15456818 DOI: 10.1523/Jneurosci.2063-04.2004 |
0.544 |
|
| 2004 |
Street LJ, Sternfeld F, Jelley RA, Reeve AJ, Carling RW, Moore KW, McKernan RM, Sohal B, Cook S, Pike A, Dawson GR, Bromidge FA, Wafford KA, Seabrook GR, Thompson SA, et al. Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site. Journal of Medicinal Chemistry. 47: 3642-57. PMID 15214791 DOI: 10.1021/jm0407613 |
0.468 |
|
| 2004 |
Cirone J, Rosahl TW, Reynolds DS, Newman RJ, O'Meara GF, Hutson PH, Wafford KA. Gamma-aminobutyric acid type A receptor beta 2 subunit mediates the hypothermic effect of etomidate in mice. Anesthesiology. 100: 1438-45. PMID 15166563 DOI: 10.1097/00000542-200406000-00016 |
0.322 |
|
| 2004 |
Wafford KA, Macaulay AJ, Fradley R, O'Meara GF, Reynolds DS, Rosahl TW. Differentiating the role of gamma-aminobutyric acid type A (GABAA) receptor subtypes. Biochemical Society Transactions. 32: 553-6. PMID 15157182 DOI: 10.1042/BST0320553 |
0.439 |
|
| 2004 |
Connolly CN, Wafford KA. The Cys-loop superfamily of ligand-gated ion channels: the impact of receptor structure on function. Biochemical Society Transactions. 32: 529-34. PMID 15157178 DOI: 10.1042/BST0320529 |
0.303 |
|
| 2004 |
Thompson SA, Wheat L, Brown NA, Wingrove PB, Pillai GV, Whiting PJ, Adkins C, Woodward CH, Smith AJ, Simpson PB, Collins I, Wafford KA. Salicylidene salicylhydrazide, a selective inhibitor of beta 1-containing GABAA receptors. British Journal of Pharmacology. 142: 97-106. PMID 15100159 DOI: 10.1038/Sj.Bjp.0705689 |
0.532 |
|
| 2004 |
Sternfeld F, Carling RW, Jelley RA, Ladduwahetty T, Merchant KJ, Moore KW, Reeve AJ, Street LJ, O'Connor D, Sohal B, Atack JR, Cook S, Seabrook G, Wafford K, Tattersall FD, et al. Selective, orally active gamma-aminobutyric acidA alpha5 receptor inverse agonists as cognition enhancers. Journal of Medicinal Chemistry. 47: 2176-9. PMID 15084116 DOI: 10.1021/jm031076j |
0.432 |
|
| 2004 |
Crawforth J, Atack JR, Cook SM, Gibson KR, Nadin A, Owens AP, Pike A, Rowley M, Smith AJ, Sohal B, Sternfeld F, Wafford K, Street LJ. Tricyclic pyridones as functionally selective human GABA Aα2/3 receptor-ion channel ligands Bioorganic and Medicinal Chemistry Letters. 14: 1679-1682. PMID 15026049 DOI: 10.1016/j.bmcl.2004.01.057 |
0.434 |
|
| 2004 |
Caraiscos VB, Elliott EM, You-Ten KE, Cheng VY, Belelli D, Newell JG, Jackson MF, Lambert JJ, Rosahl TW, Wafford KA, MacDonald JF, Orser BA. Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors. Proceedings of the National Academy of Sciences of the United States of America. 101: 3662-7. PMID 14993607 DOI: 10.1073/Pnas.0307231101 |
0.578 |
|
| 2004 |
McCabe C, Shaw D, Atack JR, Street LJ, Wafford KA, Dawson GR, Reynolds DS, Leslie JC. Subtype-selective GABAergic drugs facilitate extinction of mouse operant behaviour. Neuropharmacology. 46: 171-8. PMID 14680756 DOI: 10.1016/J.Neuropharm.2003.09.004 |
0.418 |
|
| 2003 |
Priestley CM, Williamson EM, Wafford KA, Sattelle DB. Thymol, a constituent of thyme essential oil, is a positive allosteric modulator of human GABA(A) receptors and a homo-oligomeric GABA receptor from Drosophila melanogaster. British Journal of Pharmacology. 140: 1363-72. PMID 14623762 DOI: 10.1038/sj.bjp.0705542 |
0.732 |
|
| 2003 |
Usala M, Thompson SA, Whiting PJ, Wafford KA. Activity of chlormethiazole at human recombinant GABA(A) and NMDA receptors. British Journal of Pharmacology. 140: 1045-50. PMID 14530209 DOI: 10.1038/sj.bjp.0705540 |
0.508 |
|
| 2003 |
Reynolds DS, Rosahl TW, Cirone J, O'Meara GF, Haythornthwaite A, Newman RJ, Myers J, Sur C, Howell O, Rutter AR, Atack J, Macaulay AJ, Hadingham KL, Hutson PH, Belelli D, ... ... Wafford KA, et al. Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8608-17. PMID 13679430 DOI: 10.1523/Jneurosci.23-24-08608.2003 |
0.403 |
|
| 2003 |
Mortensen M, Wafford KA, Wingrove P, Ebert B. Pharmacology of GABA(A) receptors exhibiting different levels of spontaneous activity. European Journal of Pharmacology. 476: 17-24. PMID 12969744 DOI: 10.1016/S0014-2999(03)02125-3 |
0.63 |
|
| 2003 |
Maksay G, Thompson SA, Wafford KA. The pharmacology of spontaneously open alpha 1 beta 3 epsilon GABA A receptor-ionophores. Neuropharmacology. 44: 994-1002. PMID 12763092 DOI: 10.1016/S0028-3908(03)00116-3 |
0.516 |
|
| 2002 |
Thompson SA, Bonnert TP, Cagetti E, Whiting PJ, Wafford KA. Overexpression of the GABA(A) receptor epsilon subunit results in insensitivity to anaesthetics. Neuropharmacology. 43: 662-8. PMID 12367611 DOI: 10.1016/S0028-3908(02)00162-4 |
0.422 |
|
| 2002 |
Grimwood S, Wafford KA, Macaulay A, Hutson PH. N-Methyl-D-aspartate receptor subtype-selectivity of homoquinolinate: an electrophysiological and radioligand binding study using both native and recombinant receptors. Journal of Neurochemistry. 82: 794-800. PMID 12358784 DOI: 10.1046/j.1471-4159.2002.01014.x |
0.342 |
|
| 2002 |
Brown N, Kerby J, Bonnert TP, Whiting PJ, Wafford KA. Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors. British Journal of Pharmacology. 136: 965-74. PMID 12145096 DOI: 10.1038/sj.bjp.0704795 |
0.383 |
|
| 2002 |
Collins I, Moyes C, Davey WB, Rowley M, Bromidge FA, Quirk K, Atack JR, McKernan RM, Thompson SA, Wafford K, Dawson GR, Pike A, Sohal B, Tsou NN, Ball RG, et al. 3-Heteroaryl-2-pyridones: benzodiazepine site ligands with functional delectivity for alpha 2/alpha 3-subtypes of human GABA(A) receptor-ion channels. Journal of Medicinal Chemistry. 45: 1887-900. PMID 11960500 DOI: 10.1021/Jm0110789 |
0.377 |
|
| 2002 |
Thompson SA, Wingrove PB, Connelly L, Whiting PJ, Wafford KA. Tracazolate reveals a novel type of allosteric interaction with recombinant gamma-aminobutyric acid(A) receptors. Molecular Pharmacology. 61: 861-9. PMID 11901225 DOI: 10.1124/mol.61.4.861 |
0.629 |
|
| 2002 |
Chambers MS, Atack JR, Bromidge FA, Broughton HB, Cook S, Dawson GR, Hobbs SC, Maubach KA, Reeve AJ, Seabrook GR, Wafford K, Ma AM. 6,7-Dihydro-2-benzothiophen-4(5H)-ones: A novel class of GABA-A α5 receptor inverse agonists Journal of Medicinal Chemistry. 45: 1176-1179. PMID 11881985 DOI: 10.1021/jm010471b |
0.552 |
|
| 2002 |
Wingrove PB, Safo P, Wheat L, Thompson SA, Wafford KA, Whiting PJ. Mechanism of alpha-subunit selectivity of benzodiazepine pharmacology at gamma-aminobutyric acid type A receptors. European Journal of Pharmacology. 437: 31-9. PMID 11864636 DOI: 10.1016/S0014-2999(02)01279-7 |
0.441 |
|
| 2001 |
Ebert B, Mortensen M, Thompson SA, Kehler J, Wafford KA, Krogsgaard-Larsen P. Bioisosteric determinants for subtype selectivity of ligands for heteromeric GABA(A) receptors. Bioorganic & Medicinal Chemistry Letters. 11: 1573-7. PMID 11412984 DOI: 10.1016/S0960-894X(01)00184-6 |
0.634 |
|
| 2001 |
Sur C, Wafford KA, Reynolds DS, Hadingham KL, Bromidge F, Macaulay A, Collinson N, O'Meara G, Howell O, Newman R, Myers J, Atack JR, Dawson GR, McKernan RM, Whiting PJ, et al. Loss of the major GABA(A) receptor subtype in the brain is not lethal in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 3409-18. PMID 11331371 |
0.431 |
|
| 2001 |
Maskell PD, Wafford KA, Bermudez I. Effects of gamma-HCH and delta-HCH on human recombinant GABA(A) receptors: dependence on GABA(A) receptor subunit combination. British Journal of Pharmacology. 132: 205-12. PMID 11156579 DOI: 10.1038/sj.bjp.0703824 |
0.594 |
|
| 2000 |
Dawson GR, Wafford KA, Smith A, Marshall GR, Bayley PJ, Schaeffer JM, Meinke PT, McKernan RM. Anticonvulsant and adverse effects of avermectin analogs in mice are mediated through the gamma-aminobutyric acid(A) receptor. The Journal of Pharmacology and Experimental Therapeutics. 295: 1051-60. PMID 11082440 |
0.617 |
|
| 2000 |
Collins I, Davey WB, Rowley M, Quirk K, Bromidge FA, McKernan RM, Thompson SA, Wafford KA. N-(indol-3-ylglyoxylyl)piperidines: high affinity agonists of human GABA-A receptors containing the alpha1 subunit. Bioorganic & Medicinal Chemistry Letters. 10: 1381-4. PMID 10890169 DOI: 10.1016/S0960-894X(00)00245-6 |
0.466 |
|
| 2000 |
McKernan RM, Rosahl TW, Reynolds DS, Sur C, Wafford KA, Atack JR, Farrar S, Myers J, Cook G, Ferris P, Garrett L, Bristow L, Marshall G, Macaulay A, Brown N, et al. Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype. Nature Neuroscience. 3: 587-92. PMID 10816315 DOI: 10.1038/75761 |
0.603 |
|
| 2000 |
Maksay G, Thompson SA, Wafford KA. Allosteric modulators affect the efficacy of partial agonists for recombinant GABA(A) receptors. British Journal of Pharmacology. 129: 1794-800. PMID 10780988 DOI: 10.1038/sj.bjp.0703259 |
0.582 |
|
| 1999 |
Thompson SA, Smith MZ, Wingrove PB, Whiting PJ, Wafford KA. Mutation at the putative GABA(A) ion-channel gate reveals changes in allosteric modulation. British Journal of Pharmacology. 127: 1349-58. PMID 10455284 DOI: 10.1038/sj.bjp.0702687 |
0.645 |
|
| 1999 |
Bonnert TP, McKernan RM, Farrar S, le Bourdellès B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Brown N, Wafford KA, Whiting PJ. theta, a novel gamma-aminobutyric acid type A receptor subunit. Proceedings of the National Academy of Sciences of the United States of America. 96: 9891-6. PMID 10449790 DOI: 10.1073/pnas.96.17.9891 |
0.477 |
|
| 1999 |
Whiting PJ, Bonnert TP, McKernan RM, Farrar S, Le Bourdellès B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Thompson SA, Wafford KA. Molecular and functional diversity of the expanding GABA-A receptor gene family. Annals of the New York Academy of Sciences. 868: 645-53. PMID 10414349 DOI: 10.1111/j.1749-6632.1999.tb11341.x |
0.587 |
|
| 1999 |
Thompson SA, Arden SA, Marshall G, Wingrove PB, Whiting PJ, Wafford KA. Residues in transmembrane domains I and II determine gamma-aminobutyric acid type AA receptor subtype-selective antagonism by furosemide. Molecular Pharmacology. 55: 993-9. PMID 10347239 |
0.52 |
|
| 1998 |
Thompson SA, Bonnert TP, Whiting PJ, Wafford KA. Functional characteristics of recombinant human GABA(A) receptors containing the epsilon-subunit. Toxicology Letters. 100: 233-8. PMID 10049148 DOI: 10.1016/S0378-4274(98)00190-8 |
0.619 |
|
| 1997 |
Ebert B, Thompson SA, Saounatsou K, McKernan R, Krogsgaard-Larsen P, Wafford KA. Differences in agonist/antagonist binding affinity and receptor transduction using recombinant human gamma-aminobutyric acid type A receptors. Molecular Pharmacology. 52: 1150-6. PMID 9396785 |
0.472 |
|
| 1997 |
Whiting PJ, McAllister G, Bonnert T, Heavens RP, Rigby MR, Sirinathsinghji DJ, Marshall G, Thompson SA, Wafford KA. The use of expressed sequence tag databases to identify novel human gamma-aminobutyric acid type receptor genes. Biochemical Society Transactions. 25: 817-9. PMID 9388552 |
0.325 |
|
| 1997 |
Belelli D, Lambert JJ, Peters JA, Wafford K, Whiting PJ. The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid. Proceedings of the National Academy of Sciences of the United States of America. 94: 11031-6. PMID 9380754 DOI: 10.1073/Pnas.94.20.11031 |
0.411 |
|
| 1997 |
Wingrove PB, Thompson SA, Wafford KA, Whiting PJ. Key amino acids in the gamma subunit of the gamma-aminobutyric acidA receptor that determine ligand binding and modulation at the benzodiazepine site. Molecular Pharmacology. 52: 874-81. PMID 9351978 |
0.373 |
|
| 1997 |
Aspinwall LS, Bermudez I, King LA, Wafford KA. The interactions of hexachlorocyclohexane isomers with human gamma-aminobutyric acid(A) receptors expressed in Xenopus oocytes. The Journal of Pharmacology and Experimental Therapeutics. 282: 1557-64. PMID 9316872 |
0.612 |
|
| 1997 |
Whiting PJ, McAllister G, Vassilatis D, Bonnert TP, Heavens RP, Smith DW, Hewson L, O'Donnell R, Rigby MR, Sirinathsinghji DJ, Marshall G, Thompson SA, Wafford KA, Vasilatis D. Neuronally restricted RNA splicing regulates the expression of a novel GABAA receptor subunit conferring atypical functional properties [corrected; erratum to be published]. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 5027-37. PMID 9185540 |
0.468 |
|
| 1997 |
Brehm L, Ebert B, Kristiansen U, Wafford KA, Kemp JA, Krogsgaard-Larsen P. Structure and pharmacology of 4,5,6,7-tetrahydroisothiazolo [5,4-c]pyridin-3-ol (Thio-THIP), an agonist/antagonist at GABA(A) receptors European Journal of Medicinal Chemistry. 32: 357-363. DOI: 10.1016/S0223-5234(97)89089-7 |
0.493 |
|
| 1996 |
Thompson SA, Whiting PJ, Wafford KA. Barbiturate interactions at the human GABAA receptor: dependence on receptor subunit combination. British Journal of Pharmacology. 117: 521-527. PMID 8821543 |
0.409 |
|
| 1996 |
Wafford KA, Thompson SA, Thomas D, Sikela J, Wilcox AS, Whiting PJ. Functional characterization of human gamma-aminobutyric acidA receptors containing the alpha 4 subunit. Molecular Pharmacology. 50: 670-8. PMID 8794909 |
0.342 |
|
| 1996 |
Hadingham KL, Garrett EM, Wafford KA, Bain C, Heavens RP, Sirinathsinghji DJ, Whiting PJ. Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors. Molecular Pharmacology. 49: 253-9. PMID 8632757 |
0.423 |
|
| 1995 |
Mckernan RM, Wafford K, Quirk K, Hadingham KL, Harley EA, Ragan CI, Whiting PJ. The pharmacology of the benzodiazepine site of the GABA-a receptor is dependent on the type of γsubunit present Journal of Receptors and Signal Transduction. 15: 173-183. PMID 8903939 DOI: 10.3109/10799899509045215 |
0.568 |
|
| 1995 |
Hadingham KL, Wafford KA, Thompson SA, Palmer KJ, Whiting PJ. Expression and pharmacology of human GABAA receptors containing gamma 3 subunits. European Journal of Pharmacology. 291: 301-9. PMID 8719414 DOI: 10.1016/0922-4106(95)90070-5 |
0.305 |
|
| 1995 |
Whiting PJ, McKernan RM, Wafford KA. Structure and pharmacology of vertebrate GABAA receptor subtypes. International Review of Neurobiology. 38: 95-138. PMID 8537206 |
0.373 |
|
| 1995 |
Wafford KA, Kathoria M, Bain CJ, Marshall G, Le Bourdellès B, Kemp JA, Whiting PJ. Identification of amino acids in the N-methyl-D-aspartate receptor NR1 subunit that contribute to the glycine binding site. Molecular Pharmacology. 47: 374-80. PMID 7870047 |
0.37 |
|
| 1995 |
Thompson GA, Whiting PJ, Wafford KA. Differential effects on recombinant GABAA receptors reveals two distinct binding sites for pentobarbital Behavioural Pharmacology. 6: 116???117. DOI: 10.1097/00008877-199505001-00135 |
0.321 |
|
| 1994 |
Wafford KA, Bain CJ, Quirk K, McKernan RM, Wingrove PB, Whiting PJ, Kemp JA. A novel allosteric modulatory site on the GABAA receptor beta subunit. Neuron. 12: 775-82. PMID 8161449 DOI: 10.1016/0896-6273(94)90330-1 |
0.437 |
|
| 1994 |
Ebert B, Wafford KA, Whiting PJ, Krogsgaard-Larsen P, Kemp JA. Molecular pharmacology of gamma-aminobutyric acid type A receptor agonists and partial agonists in oocytes injected with different alpha, beta, and gamma receptor subunit combinations. Molecular Pharmacology. 46: 957-63. PMID 7969086 |
0.365 |
|
| 1994 |
Mihic SJ, Whiting PJ, Klein RL, Wafford KA, Harris RA. A single amino acid of the human gamma-aminobutyric acid type A receptor gamma 2 subunit determines benzodiazepine efficacy. The Journal of Biological Chemistry. 269: 32768-73. PMID 7806498 |
0.591 |
|
| 1993 |
Wafford KA, Whiting PJ, Kemp JA. Differences in affinity and efficacy of benzodiazepine receptor ligands at recombinant gamma-aminobutyric acidA receptor subtypes. Molecular Pharmacology. 43: 240-4. PMID 8381510 |
0.387 |
|
| 1993 |
Hadingham KL, Wingrove PB, Wafford KA, Bain C, Kemp JA, Palmer KJ, Wilson AW, Wilcox AS, Sikela JM, Ragan CI. Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors. Molecular Pharmacology. 44: 1211-8. PMID 8264558 |
0.332 |
|
| 1993 |
Wafford KA, Bain CJ, Whiting PJ, Kemp JA. Functional comparison of the role of gamma subunits in recombinant human gamma-aminobutyric acidA/benzodiazepine receptors. Molecular Pharmacology. 44: 437-42. PMID 8102787 |
0.346 |
|
| 1993 |
Wafford KA, Bain CJ, Le Bourdelles B, Whiting PJ, Kemp JA. Preferential co-assembly of recombinant NMDA receptors composed of three different subunits. Neuroreport. 4: 1347-9. PMID 7903167 |
0.316 |
|
| 1993 |
Wafford KA, Burnett D, Harris RA, Whiting PJ. GABAA receptor subunit expression and sensitivity to ethanol. Alcohol and Alcoholism (Oxford, Oxfordshire). Supplement. 2: 327-30. PMID 7748319 |
0.452 |
|
| 1993 |
Ragan CI, McKernan RM, Wafford K, Whiting PJ. γ-Aminobutyric acid-A (GABA-A) receptor/ion channel complex Biochemical Society Transactions. 21: 622-626. PMID 7693526 DOI: 10.1042/BST0210622 |
0.532 |
|
| 1993 |
Rauh JJ, Vassallo JG, Lummis SCR, Wafford KA, Sattelle DB. Steroids reveal differences between GABA-operated chloride channels of insects and vertebrates Molecular Neuropharmacology. 3: 1-9. |
0.598 |
|
| 1992 |
Wafford KA, Whiting P, Kemp JA. Functional modulation of cloned GABAA receptors expressed in Xenopus oocytes. Advances in Biochemical Psychopharmacology. 47: 75-9. PMID 1354921 |
0.324 |
|
| 1992 |
Wafford KA, Bai D, Sattelle DB. A novel kainate receptor in the insect nervous system. Neuroscience Letters. 141: 273-6. PMID 1331899 DOI: 10.1016/0304-3940(92)90912-Q |
0.587 |
|
| 1992 |
Wafford KA, Whiting PJ. Ethanol potentiation of GABAA receptors requires phosphorylation of the alternatively spliced variant of the gamma 2 subunit. Febs Letters. 313: 113-7. PMID 1330701 DOI: 10.1016/0014-5793(92)81424-K |
0.346 |
|
| 1992 |
Wingrove P, Hadingham K, Wafford K, Kemp JA, Ragan CI, Whiting P. Cloning and expression of a cDNA encoding the human GABA-A receptor α5 subunit Biochemical Society Transactions. 20. PMID 1321750 DOI: 10.1042/BST020018S |
0.5 |
|
| 1991 |
Wafford KA, Burnett DM, Leidenheimer NJ, Burt DR, Wang JB, Kofuji P, Dunwiddie TV, Harris RA, Sikela JM. Ethanol sensitivity of the GABAA receptor expressed in Xenopus oocytes requires 8 amino acids contained in the gamma 2L subunit. Neuron. 7: 27-33. PMID 1712603 DOI: 10.1016/0896-6273(91)90071-7 |
0.43 |
|
| 1989 |
Sattelle DB, Buckingham SD, Wafford KA, Sherby SM, Bakry NM, Eldefrawi AT, Eldefrawi ME, May TE. Actions of the insecticide 2(nitromethylene)tetrahydro-1,3-thiazine on insect and vertebrate nicotinic acetylcholine receptors. Proceedings of the Royal Society of London. Series B, Biological Sciences. 237: 501-14. PMID 2479949 DOI: 10.1098/Rspb.1989.0062 |
0.582 |
|
| 1989 |
Wafford KA, Lummis SC, Sattelle DB. Block of an insect central nervous system GABA receptor by cyclodiene and cyclohexane insecticides. Proceedings of the Royal Society of London. Series B, Biological Sciences. 237: 53-61. PMID 2474166 DOI: 10.1098/Rspb.1989.0036 |
0.732 |
|
| 1989 |
Wafford KA, Sattelle DB, Gant DB, Eldefrawi AT, Eldefrawi ME. Noncompetitive inhibition of GABA receptors in insect and vertebrate CNS by endrin and lindane Pesticide Biochemistry and Physiology. 33: 213-219. DOI: 10.1016/0048-3575(89)90119-3 |
0.747 |
|
| 1988 |
Sattelle DB, Pinnock RD, Wafford KA, David JA. GABA receptors on the cell-body membrane of an identified insect motor neuron. Proceedings of the Royal Society of London. Series B, Biological Sciences. 232: 443-56. PMID 2451252 DOI: 10.1098/Rspb.1988.0006 |
0.654 |
|
| 1987 |
Wafford KA, Sattelle DB, Abalis I, Eldefrawi AT, Eldefrawi ME. gamma-Aminobutyric acid-activated 36Cl- influx: a functional in vitro assay for CNS gamma-aminobutyric acid receptors of insects. Journal of Neurochemistry. 48: 177-80. PMID 3025362 DOI: 10.1111/j.1471-4159.1987.tb13144.x |
0.695 |
|
| 1987 |
Sherby SM, Eldefrawi ME, Wafford KA, Sattelle DB, Eldefrawi AT. Pharmacology of putative glutamate receptors from insect skeletal muscles, insect central nervous system and rat brain. Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology. 87: 99-106. PMID 2885148 DOI: 10.1016/0742-8413(87)90189-7 |
0.45 |
|
| 1986 |
Wafford KA, Sattelle DB. Effects of amino acid neurotransmitter candidates on an identified insect motoneurone. Neuroscience Letters. 63: 135-40. PMID 2869456 DOI: 10.1016/0304-3940(86)90050-9 |
0.605 |
|
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