Robert Gerald Whalen - Publications

Affiliations: 
1999-2009 Maxygen, Inc. 
 2010-2018 Altravax, Inc. 
 2019- Maxygen LLC 
Area:
Directed Evolution
Website:
https://www.maxygen.com

70 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
1998 Lakich MM, Diagana TT, North DL, Whalen RG. MEF-2 and Oct-1 bind to two homologous promoter sequence elements and participate in the expression of a skeletal muscle-specific gene. The Journal of Biological Chemistry. 273: 15217-26. PMID 9614136 DOI: 10.1074/Jbc.273.24.15217  0.52
1997 Diagana TT, North DL, Jabet C, Fiszman MY, Takeda S, Whalen RG. The transcriptional activity of a muscle-specific promoter depends critically on the structure of the TATA element and its binding protein. Journal of Molecular Biology. 265: 480-93. PMID 9048943 DOI: 10.1006/Jmbi.1996.0752  0.532
1996 Davis HL, Mancini M, Michel ML, Whalen RG. DNA-mediated immunization to hepatitis B surface antigen: longevity of primary response and effect of boost. Vaccine. 14: 910-5. PMID 8843634 DOI: 10.1016/0264-410X(95)00255-Y  0.302
1996 Bigard XA, Merino D, Serrurier B, Lienhard F, Guezennec YC, Bockhold KJ, Whalen RG. Role of weight-bearing function on expression of myosin isoforms during regeneration of rat soleus muscles. The American Journal of Physiology. 270: C763-71. PMID 8638655  0.558
1995 Barjot C, Cotten ML, Goblet C, Whalen RG, Bacou F. Expression of myosin heavy chain and of myogenic regulatory factor genes in fast or slow rabbit muscle satellite cell cultures. Journal of Muscle Research and Cell Motility. 16: 619-28. PMID 8750233 DOI: 10.1007/Bf00130243  0.621
1995 Whalen RG, Leclerc C, Dériaud E, Schirmbeck R, Reimann J, Davis HL. DNA-mediated immunization to the hepatitis B surface antigen. Activation and entrainment of the immune response. Annals of the New York Academy of Sciences. 772: 64-76. PMID 8546414 DOI: 10.1111/J.1749-6632.1995.Tb44732.X  0.449
1995 Davis HL, Michel ML, Whalen RG. Use of plasmid DNA for direct gene transfer and immunization. Annals of the New York Academy of Sciences. 772: 21-9. PMID 8546395 DOI: 10.1111/j.1749-6632.1995.tb44728.x  0.449
1995 Takeda S, North DL, Diagana T, Miyagoe Y, Lakich MM, Whalen RG. Myogenic regulatory factors can activate TATA-containing promoter elements via an E-box independent mechanism. The Journal of Biological Chemistry. 270: 15664-70. PMID 7797566 DOI: 10.1074/Jbc.270.26.15664  0.474
1995 Goblet C, Whalen RG. Modifications of gene expression in myotonic murine skeletal muscle are associated with abnormal expression of myogenic regulatory factors. Developmental Biology. 170: 262-73. PMID 7649361 DOI: 10.1006/Dbio.1995.1213  0.592
1994 Davis HL, Michel ML, Mancini M, Schleef M, Whalen RG. Direct gene transfer in skeletal muscle: plasmid DNA-based immunization against the hepatitis B virus surface antigen. Vaccine. 12: 1503-9. PMID 7879414 DOI: 10.1016/0264-410X(94)90073-6  0.552
1993 Soussi-Yanicostas N, Whalen RG, Petit C. Five skeletal myosin heavy chain genes are organized as a multigene complex in the human genome. Human Molecular Genetics. 2: 563-9. PMID 8518795 DOI: 10.1093/Hmg/2.5.563  0.313
1993 Russell SD, Cambon NA, Whalen RG. Two types of neonatal-to-adult fast myosin heavy chain transitions in rat hindlimb muscle fibers. Developmental Biology. 157: 359-70. PMID 8500649 DOI: 10.1006/Dbio.1993.1141  0.565
1993 Davis HL, Whalen RG, Demeneix BA. Direct gene transfer into skeletal muscle in vivo: factors affecting efficiency of transfer and stability of expression. Human Gene Therapy. 4: 151-9. PMID 8494924 DOI: 10.1089/Hum.1993.4.2-151  0.51
1993 Davis HL, Michel ML, Whalen RG. DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody. Human Molecular Genetics. 2: 1847-51. PMID 8281146 DOI: 10.1093/Hmg/2.11.1847  0.466
1993 Davis HL, Demeneix BA, Quantin B, Coulombe J, Whalen RG. Plasmid DNA is superior to viral vectors for direct gene transfer into adult mouse skeletal muscle. Human Gene Therapy. 4: 733-40. PMID 8186288 DOI: 10.1089/Hum.1993.4.6-733  0.59
1992 Ontell MP, Moschella MC, Schiaffino S, Butler-Browne G, Whalen R, Ontell M. Modification of the dystrophic phenotype after transient neonatal denervation: role of MHC isoforms. Journal of Neurobiology. 23: 751-65. PMID 1431844 DOI: 10.1002/Neu.480230612  0.581
1992 Takeda S, North DL, Lakich MM, Russell SD, Whalen RG. A possible regulatory role for conserved promoter motifs in an adult-specific muscle myosin gene from mouse. The Journal of Biological Chemistry. 267: 16957-67. PMID 1324916  0.512
1992 Takeda S, North DL, Lakich MM, Russell SD, Kahng LS, Whalen RG. Evolutionarily conserved promoter motifs and enhancer organization in the mouse gene encoding the IIB myosin heavy chain isoform expressed in adult fast skeletal muscle. Comptes Rendus De L'AcadéMie Des Sciences. SéRie Iii, Sciences De La Vie. 315: 467-72. PMID 1297523  0.448
1992 Lucas M, Goblet C, Keller A, Lamandé N, Gros F, Whalen RG, Lazar M. Modulation of embryonic and muscle-specific enolase gene products in the developing mouse hindlimb. Differentiation; Research in Biological Diversity. 51: 1-7. PMID 1280607 DOI: 10.1111/J.1432-0436.1992.Tb00674.X  0.618
1991 LaFramboise WA, Daood MJ, Guthrie RD, Schiaffino S, Moretti P, Brozanski B, Ontell MP, Butler-Browne GS, Whalen RG, Ontell M. Emergence of the mature myosin phenotype in the rat diaphragm muscle. Developmental Biology. 144: 1-15. PMID 1995390 DOI: 10.1016/0012-1606(91)90473-G  0.534
1991 Brozanski BS, Daood MJ, LaFramboise WA, Watchko JF, Foley TP, Butler-Browne GS, Whalen RG, Guthrie RD, Ontell M. Effects of perinatal undernutrition on elimination of immature myosin isoforms in the rat diaphragm. The American Journal of Physiology. 261: L49-54. PMID 1831330  0.317
1990 Whalen RG, Harris JB, Butler-Browne GS, Sesodia S. Expression of myosin isoforms during notexin-induced regeneration of rat soleus muscles. Developmental Biology. 141: 24-40. PMID 2391004 DOI: 10.1016/0012-1606(90)90099-5  0.606
1990 LaFramboise WA, Daood MJ, Guthrie RD, Butler-Browne GS, Whalen RG, Ontell M. Myosin isoforms in neonatal rat extensor digitorum longus, diaphragm, and soleus muscles. The American Journal of Physiology. 259: L116-22. PMID 2382729  0.551
1990 Zimmermann K, Kautz S, Hajdu G, Winter C, Whalen RG, Starzinski-Powitz A. Heterogenic mRNAs with an identical protein-coding region of the human embryonic myosin alkali light chain in skeletal muscle cells. Journal of Molecular Biology. 211: 505-13. PMID 2308163 DOI: 10.1016/0022-2836(90)90261-J  0.584
1990 TAKEDA S, LAKICH M, NORTH D, WHALEN R. Transcriptional regulation of the myosin heavy chain fast IIB gene Cell Biology International Reports. 14: 129. DOI: 10.1016/0309-1651(90)90618-9  0.314
1989 Prulière G, Butler-Browne GS, Cambon N, Toutant M, Whalen RG. Induction and stability of the adult myosin phenotype in striated muscles of dwarf mice after chronic thyroid hormone treatment. European Journal of Biochemistry / Febs. 185: 555-61. PMID 2531663 DOI: 10.1111/J.1432-1033.1989.Tb15149.X  0.587
1988 Vivarelli E, Brown WE, Whalen RG, Cossu G. The expression of slow myosin during mammalian somitogenesis and limb bud differentiation. The Journal of Cell Biology. 107: 2191-7. PMID 3058719  0.463
1988 Russell SD, Cambon N, Nadal-Ginard B, Whalen RG. Thyroid hormone induces a nerve-independent precocious expression of fast myosin heavy chain mRNA in rat hindlimb skeletal muscle. The Journal of Biological Chemistry. 263: 6370-4. PMID 2834375  0.462
1987 Butler-Browne GS, Prulière G, Cambon N, Whalen RG. Influence of the dwarf mouse mutation on skeletal and cardiac myosin isoforms. Effect of one injection of thyroxine on skeletal and cardiac muscle phenotype. The Journal of Biological Chemistry. 262: 15188-93. PMID 3667629  0.49
1986 Ecob-Prince MS, Jenkison M, Butler-Browne GS, Whalen RG. Neonatal and adult myosin heavy chain isoforms in a nerve-muscle culture system. The Journal of Cell Biology. 103: 995-1005. PMID 3745278 DOI: 10.1083/Jcb.103.3.995  0.547
1985 Brown WE, Salmons S, Whalen RG. Mechanisms underlying the asynchronous replacement of myosin light chain isoforms during stimulation-induced fibre-type transformation of skeletal muscle. Febs Letters. 192: 235-8. PMID 4065324 DOI: 10.1016/0014-5793(85)80114-9  0.523
1985 Whalen RG, Toutant M, Butler-Browne GS, Watkins SC. Hereditary pituitary dwarfism in mice affects skeletal and cardiac myosin isozyme transitions differently. The Journal of Cell Biology. 101: 603-9. PMID 4019584 DOI: 10.1083/Jcb.101.2.603  0.503
1985 Whalen RG, Bugaisky LB, Butler-Browne GS, Ecob MS, Pinset C. Synthesis and accumulation of myosin isozymes in tissue culture. Advances in Experimental Medicine and Biology. 182: 193-9. PMID 4003158 DOI: 10.1007/978-1-4684-4907-5_16  0.6
1985 Pinset C, Whalen RG. Induction of myogenic differentiation in serum-free medium does not require DNA synthesis. Developmental Biology. 108: 284-9. PMID 3908188 DOI: 10.1016/0012-1606(85)90032-6  0.489
1985 Whalen RG. Myosin isoenzymes as molecular markers for muscle physiology. The Journal of Experimental Biology. 115: 43-53. PMID 3897445  0.538
1985 Wieczorek DF, Periasamy M, Butler-Browne GS, Whalen RG, Nadal-Ginard B. Co-expression of multiple myosin heavy chain genes, in addition to a tissue-specific one, in extraocular musculature. The Journal of Cell Biology. 101: 618-29. PMID 3894379 DOI: 10.1083/Jcb.101.2.618  0.499
1985 Whalen RG, Butler-Browne GS, Bugaisky LB, Harris JB, Herliocoviez D. Myosin isozyme transitions in developing and regenerating rat muscle. Advances in Experimental Medicine and Biology. 182: 249-57. PMID 3890477 DOI: 10.1007/978-1-4684-4907-5_21  0.608
1984 Pinset C, Whalen RG. Manipulation of medium conditions and differentiation in the rat myogenic cell line L6. Developmental Biology. 102: 269-77. PMID 6706000 DOI: 10.1016/0012-1606(84)90192-1  0.436
1984 Butler-Browne GS, Herlicoviez D, Whalen RG. Effects of hypothyroidism on myosin isozyme transitions in developing rat muscle. Febs Letters. 166: 71-5. PMID 6692924 DOI: 10.1016/0014-5793(84)80047-2  0.57
1984 Whalen RG, Johnstone D, Bryers PS, Butler-Browne GS, Ecob MS, Jaros E. A developmentally regulated disappearance of slow myosin in fast-type muscles of the mouse. Febs Letters. 177: 51-6. PMID 6389176 DOI: 10.1016/0014-5793(84)80979-5  0.585
1984 Bugaisky LB, Butler-Browne GS, Sell SM, Whalen RG. Structural differences in the subfragment 1 and rod portions of myosin isozymes from adult and developing rat skeletal muscles. The Journal of Biological Chemistry. 259: 7212-8. PMID 6373769  0.328
1984 Thornell LE, Billeter R, Butler-Browne GS, Eriksson PO, Ringqvist M, Whalen RG. Development of fiber types in human fetal muscle. An immunocytochemical study. Journal of the Neurological Sciences. 66: 107-15. PMID 6240526 DOI: 10.1016/0022-510X(84)90146-1  0.549
1984 Thornell LE, Edström L, Billeter R, Butler-Browne GS, Kjörell U, Whalen RG. Muscle fibre type composition in distal myopathy (Welander). An analysis with enzyme- and immuno-histochemical, gel-electrophoretic and ultrastructural techniques. Journal of the Neurological Sciences. 65: 269-92. PMID 6238134 DOI: 10.1016/0022-510X(84)90091-1  0.588
1984 Butler-Browne GS, Whalen RG. Myosin isozyme transitions occurring during the postnatal development of the rat soleus muscle. Developmental Biology. 102: 324-34. PMID 6200371 DOI: 10.1016/0012-1606(84)90197-0  0.53
1984 Bugaisky LB, Butler-Browne GS, Whalen RG. Structural differences of myosin isozymes from adult and developing rat skeletal muscles Federation Proceedings. 43: no. 774.  0.502
1983 Brown WE, Salmons S, Whalen RG. The sequential replacement of myosin subunit isoforms during muscle type transformation induced by long term electrical stimulation. The Journal of Biological Chemistry. 258: 14686-92. PMID 6643504  0.454
1983 Ecob MS, Butler-Browne GS, Whalen RG. The adult fast isozyme of myosin is present in a nerve-muscle tissue culture system. Differentiation; Research in Biological Diversity. 25: 84-7. PMID 6229440 DOI: 10.1111/J.1432-0436.1984.Tb01342.X  0.574
1983 Bugaisky LB, Siegel E, Whalen RG. Myosin isozyme changes in the heart following constriction of the ascending aorta of a 25-day old rat. Febs Letters. 161: 230-4. PMID 6225682 DOI: 10.1016/0014-5793(83)81014-X  0.307
1982 Butler-Browne GS, Bugaisky LB, Cuénoud S, Schwartz K, Whalen RG. Denervation of newborn rat muscle does not block the appearance of adult fast myosin heavy chain. Nature. 299: 830-3. PMID 7133123 DOI: 10.1038/299830A0  0.615
1982 Whalen RG, Ecob MS. Two-dimensional electrophoretic analysis of muscle contractile proteins in patients with idiopathic scoliosis. Clinical Chemistry. 28: 1036-40. PMID 7074863  0.54
1982 Whalen RG, Sell SM, Eriksson A, Thornell LE. Myosin subunit types in skeletal and cardiac tissues and their developmental distribution. Developmental Biology. 91: 478-84. PMID 7047262 DOI: 10.1016/0012-1606(82)90055-0  0.569
1982 Pinset C, Gros F, Whalen R. [Proliferation and differentiation of a myogenic line in synthetic media]. Comptes Rendus Des SéAnces De L'AcadéMie Des Sciences. SéRie Iii, Sciences De La Vie. 295: 727-32. PMID 6820306  0.559
1982 Whalen R. [Cellular contractility: smooth muscle cells]. Nouvelle Revue FrançAise D'HéMatologie. 24: 123-5. PMID 6215621  0.545
1981 Whalen RG, Sell SM, Butler-Browne GS, Schwartz K, Bouveret P, Pinset-Härstöm I. Three myosin heavy-chain isozymes appear sequentially in rat muscle development. Nature. 292: 805-9. PMID 7196501 DOI: 10.1038/292805A0  0.563
1980 Marks A, Thibault J, Whalen RG, Mahony JB, Law J, Gros F. Selective action of colchicine on protein synthesis and release in a clonal line of rat glial cells. Biochimie. 62: 705-12. PMID 7448236 DOI: 10.1016/S0300-9084(80)80028-9  0.553
1980 Whalen RG, Sell SM. Myosin from fetal hearts contains the skeletal muscle embryonic light chain. Nature. 286: 731-3. PMID 7412860 DOI: 10.1038/286731A0  0.623
1979 Pinset-Härström I, Whalen RG. Effect of ageing of myosin on its ability to form synthetic filaments and on proteolysis of the LC2 light chain. Journal of Molecular Biology. 134: 189-97. PMID 575391 DOI: 10.1016/0022-2836(79)90420-0  0.412
1979 Whalen RG, Butler-Browne GS, Sell S, Gros F. Transitions in contractile protein isozymes during muscle cell differentiation. Biochimie. 61: 625-32. PMID 497252 DOI: 10.1016/S0300-9084(79)80160-1  0.649
1979 Gros F, Affara N, Buckingham ME, Jacquet M, Whalen RG, Daubas P, Lelong JC, Caput D. Biochemical aspects of muscle differentiation as analyzed by in vitro cultivation techniques. Developments in Biological Standardization. 42: 3-10. PMID 467802  0.689
1979 Whalen RG, Schwartz K, Bouveret P, Sell SM, Gros F. Contractile protein isozymes in muscle development: identification of an embryonic form of myosin heavy chain. Proceedings of the National Academy of Sciences of the United States of America. 76: 5197-201. PMID 291935 DOI: 10.1073/Pnas.76.10.5197  0.728
1978 Whalen RG, Butler-Browne GS, Gros F. Identification of a novel form of myosin light chain present in embryonic muscle tissue and cultured muscle cells. Journal of Molecular Biology. 126: 415-31. PMID 745235 DOI: 10.1016/0022-2836(78)90049-9  0.706
1978 Brevet A, Whalen RG. Comparative structural analysis of myosin after limited tryptic hydrolysis by use of two-dimensional gel electrophoresis. Biochimie. 60: 459-66. PMID 698286 DOI: 10.1016/S0300-9084(78)80860-8  0.455
1978 Whalen RG, Gros F. The majority of calf muscle cell messenger RNAs contain poly(A). Biochimica Et Biophysica Acta. 519: 372-82. PMID 667071 DOI: 10.1016/0005-2787(78)90090-4  0.635
1977 Buckingham ME, Whalen RG, Gros F. Cytoplasmic ribonucleoprotein particles in muscle cells. Biochemical Society Transactions. 5: 630-1. PMID 902877 DOI: 10.1042/Bst0050630  0.643
1977 Buckingham ME, Whalen RG, Gros F. Messenger ribonucleic acid metabolism during myogenesis. Biochemical Society Transactions. 5: 474-7. PMID 902867 DOI: 10.1042/Bst0050474A  0.491
1977 Merlie JP, Buckingham ME, Whalen RG. Molecular aspects of myogenesis. Current Topics in Developmental Biology. 11: 61-114. PMID 332455 DOI: 10.1016/S0070-2153(08)60743-7  0.622
1977 Whalen RG, Gros F. The translation of globin messenger RNA with use of muscle initiation factors. Biochimica Et Biophysica Acta. 475: 393-402. PMID 191079 DOI: 10.1016/0005-2787(77)90028-4  0.679
1976 Whalen RG, Butler-Browne GS, Gros F. Protein synthesis and actin heterogeneity in calf muscle cells in culture. Proceedings of the National Academy of Sciences of the United States of America. 73: 2018-22. PMID 1064871 DOI: 10.1073/Pnas.73.6.2018  0.697
1976 Whalen RG, Buckingham ME, Gros F. Protein and RNA synthesis in cultured muscle cells. Progress in Nucleic Acid Research and Molecular Biology. 19: 485-9. PMID 1019359 DOI: 10.1016/S0079-6603(08)60940-X  0.638
1974 Buckingham ME, Caput D, Cohen A, Whalen RG, Gros F. The synthesis and stability of cytoplasmic messenger RNA during myoblast differentiation in culture. Proceedings of the National Academy of Sciences of the United States of America. 71: 1466-70. PMID 4524649 DOI: 10.1073/Pnas.71.4.1466  0.603
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