| Year |
Citation |
Score |
| 2023 |
Horton BL, D'Souza AD, Zagorulya M, McCreery CV, Abhiraman GC, Picton LK, Sheen A, Agarwal Y, Momin N, Wittrup KD, White FM, Garcia KC, Spranger S. Overcoming lung cancer immunotherapy resistance by combining non-toxic variants of IL-12 and IL-2. Jci Insight. PMID 37669107 DOI: 10.1172/jci.insight.172728 |
0.53 |
|
| 2023 |
Tsutsumi N, Masoumi Z, James SC, Tucker JA, Winkelmann H, Grey W, Picton LK, Moss L, Wilson SC, Caveney NA, Jude KM, Gati C, Piehler J, Hitchcock IS, Garcia KC. Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis. Cell. PMID 37633268 DOI: 10.1016/j.cell.2023.07.037 |
0.763 |
|
| 2023 |
Caveney NA, Tsutsumi N, Garcia KC. Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism. Elife. 12. PMID 37535399 DOI: 10.7554/eLife.86784 |
0.753 |
|
| 2023 |
Abhiraman GC, Bruun TUJ, Caveney NA, Su LL, Saxton RA, Yin Q, Tang S, Davis MM, Jude KM, Garcia KC. A structural blueprint for interleukin-21 signal modulation. Cell Reports. 42: 112657. PMID 37339051 DOI: 10.1016/j.celrep.2023.112657 |
0.767 |
|
| 2023 |
Yang H, Ulge UY, Quijano-Rubio A, Bernstein ZJ, Maestas DR, Chun JH, Wang W, Lin JX, Jude KM, Singh S, Orcutt-Jahns BT, Li P, Mou J, Chung L, Kuo YH, ... ... Garcia KC, et al. Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds. Nature Chemical Biology. PMID 37024727 DOI: 10.1038/s41589-023-01313-6 |
0.662 |
|
| 2023 |
Saxton RA, Caveney NA, Moya-Garzon MD, Householder KD, Rodriguez GE, Burdsall KA, Long JZ, Garcia KC. Structural insights into the mechanism of leptin receptor activation. Nature Communications. 14: 1797. PMID 37002197 DOI: 10.1038/s41467-023-37169-6 |
0.761 |
|
| 2023 |
Tsutsumi N, Hwang S, Waghray D, Hansen S, Jude KM, Wang N, Miao Y, Glassman CR, Caveney NA, Janda CY, Hannoush RN, Garcia KC. Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination. Proceedings of the National Academy of Sciences of the United States of America. 120: e2218238120. PMID 36893265 DOI: 10.1073/pnas.2218238120 |
0.762 |
|
| 2023 |
Caveney NA, Saxton RA, Waghray D, Glassman CR, Tsutsumi N, Hubbard SR, Garcia KC. Structural basis of Janus kinase trans-activation. Cell Reports. 42: 112201. PMID 36867534 DOI: 10.1016/j.celrep.2023.112201 |
0.75 |
|
| 2023 |
Caveney NA, Tsutsumi N, Garcia KC. Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism. Biorxiv : the Preprint Server For Biology. PMID 36824799 DOI: 10.1101/2023.02.14.528495 |
0.754 |
|
| 2022 |
Stern LA, Gholamin S, Moraga I, Yang X, Saravanakumar S, Cohen JR, Starr R, Aguilar B, Salvary V, Hibbard JC, Kalbasi A, Shepphird JK, O'Hearn J, Garcia KC, Brown CE. Engineered IL13 variants direct specificity of IL13Rα2-targeted CAR T cell therapy. Proceedings of the National Academy of Sciences of the United States of America. 119: e2112006119. PMID 35939683 DOI: 10.1073/pnas.2112006119 |
0.317 |
|
| 2022 |
Wilson SC, Caveney NA, Yen M, Pollmann C, Xiang X, Jude KM, Hafer M, Tsutsumi N, Piehler J, Garcia KC. Organizing Structural Principles of the Interleukin-17 Ligand-Receptor Axis. Nature. PMID 35863378 DOI: 10.1038/s41586-022-05116-y |
0.76 |
|
| 2022 |
Kalbasi A, Siurala M, Su LL, Tariveranmoshabad M, Picton LK, Ravikumar P, Li P, Lin JX, Escuin-Ordinas H, Da T, Kremer SV, Sun AL, Castelli S, Agarwal S, Scholler J, ... ... Garcia KC, et al. Potentiating adoptive cell therapy using synthetic IL-9 receptors. Nature. PMID 35676488 DOI: 10.1038/s41586-022-04801-2 |
0.305 |
|
| 2022 |
Caveney NA, Glassman CR, Jude KM, Tsutsumi N, Garcia KC. Structure of the IL-27 quaternary receptor signaling complex. Elife. 11. PMID 35579417 DOI: 10.7554/eLife.78463 |
0.777 |
|
| 2022 |
Cao L, Coventry B, Goreshnik I, Huang B, Park JS, Jude KM, Marković I, Kadam RU, Verschueren KHG, Verstraete K, Walsh STR, Bennett N, Phal A, Yang A, Kozodoy L, ... ... Garcia KC, et al. Design of protein binding proteins from target structure alone. Nature. PMID 35332283 DOI: 10.1038/s41586-022-04654-9 |
0.343 |
|
| 2022 |
Yen M, Ren J, Liu Q, Glassman CR, Sheahan TP, Picton LK, Moreira FR, Rustagi A, Jude KM, Zhao X, Blish CA, Baric RS, Su LL, Garcia KC. Facile discovery of surrogate cytokine agonists. Cell. PMID 35325595 DOI: 10.1016/j.cell.2022.02.025 |
0.349 |
|
| 2021 |
Glassman CR, Su L, Majri-Morrison SS, Winkelmann H, Mo F, Li P, Pérez-Cruz M, Ho PP, Koliesnik I, Nagy N, Hnizdilova T, Picton LK, Kovar M, Bollyky P, Steinman L, ... ... Garcia KC, et al. Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist. Elife. 10. PMID 34003116 DOI: 10.7554/eLife.65777 |
0.306 |
|
| 2021 |
Chiou SH, Tseng D, Reuben A, Mallajosyula V, Molina IS, Conley S, Wilhelmy J, McSween AM, Yang X, Nishimiya D, Sinha R, Nabet BY, Wang C, Shrager JB, Berry MF, ... ... Garcia KC, et al. Global analysis of shared T cell specificities in human non-small cell lung cancer enables HLA inference and antigen discovery. Immunity. 54: 586-602.e8. PMID 33691136 DOI: 10.1016/j.immuni.2021.02.014 |
0.403 |
|
| 2021 |
Glassman CR, Mathiharan YK, Jude KM, Su L, Panova O, Lupardus PJ, Spangler JB, Ely LK, Thomas C, Skiniotis G, Garcia KC. Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells. Cell. 184: 983-999.e24. PMID 33606986 DOI: 10.1016/j.cell.2021.01.018 |
0.666 |
|
| 2020 |
Wojtowicz WM, Vielmetter J, Fernandes RA, Siepe DH, Eastman CL, Chisholm GB, Cox S, Klock H, Anderson PW, Rue SM, Miller JJ, Glaser SM, Bragstad ML, Vance J, Lam AW, ... ... Garcia KC, et al. A Human IgSF Cell-Surface Interactome Reveals a Complex Network of Protein-Protein Interactions. Cell. 182: 1027-1043.e17. PMID 32822567 DOI: 10.1016/J.Cell.2020.07.025 |
0.355 |
|
| 2020 |
Miao Y, Ha A, de Lau W, Yuki K, Santos AJM, You C, Geurts MH, Puschhof J, Pleguezuelos-Manzano C, Peng WC, Senlice R, Piani C, Buikema JW, Gbenedio OM, Vallon M, ... ... Garcia KC, et al. Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo. Cell Stem Cell. PMID 32818433 DOI: 10.1016/J.Stem.2020.07.020 |
0.308 |
|
| 2020 |
Fernandes RA, Li C, Wang G, Yang X, Savvides CS, Glassman CR, Dong S, Luxenberg E, Sibener LV, Birnbaum ME, Benoist C, Mathis D, Garcia KC. Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices . Elife. 9. PMID 32773038 DOI: 10.7554/Elife.58463 |
0.707 |
|
| 2020 |
Tsutsumi N, Mukherjee S, Waghray D, Janda CY, Jude KM, Miao Y, Burg JS, Aduri NG, Kossiakoff AA, Gati C, Garcia KC. Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling. Elife. 9. PMID 32762848 DOI: 10.7554/Elife.58464 |
0.357 |
|
| 2020 |
Mendoza JL, Fischer S, Gee MH, Lam LH, Brackenridge S, Powrie FM, Birnbaum M, McMichael AJ, Garcia KC, Gillespie GM. Interrogating the recognition landscape of a conserved HIV-specific TCR reveals distinct bacterial peptide cross-reactivity. Elife. 9. PMID 32716298 DOI: 10.7554/Elife.58128 |
0.764 |
|
| 2020 |
Maeda S, Xu J, N Kadji FM, Clark MJ, Zhao J, Tsutsumi N, Aoki J, Sunahara RK, Inoue A, Garcia KC, Kobilka BK. Structure and selectivity engineering of the M muscarinic receptor toxin complex. Science (New York, N.Y.). 369: 161-167. PMID 32646996 DOI: 10.1126/Science.Aax2517 |
0.387 |
|
| 2020 |
De Paula VS, Jude KM, Nerli S, Glassman CR, Garcia KC, Sgourakis NG. Interleukin-2 druggability is modulated by global conformational transitions controlled by a helical capping switch. Proceedings of the National Academy of Sciences of the United States of America. PMID 32184322 DOI: 10.1073/Pnas.2000419117 |
0.43 |
|
| 2020 |
Wilmes S, Hafer M, Vuorio J, Tucker JA, Winkelmann H, Löchte S, Stanly TA, Pulgar Prieto KD, Poojari C, Sharma V, Richter CP, Kurre R, Hubbard SR, Garcia KC, Moraga I, et al. Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations. Science (New York, N.Y.). 367: 643-652. PMID 32029621 DOI: 10.1126/Science.Aaw3242 |
0.407 |
|
| 2020 |
Luca VC, Miao Y, Li X, Hollander MJ, Kuo CJ, Garcia KC. Surrogate R-spondins for tissue-specific potentiation of Wnt Signaling. Plos One. 15: e0226928. PMID 31914456 DOI: 10.1371/Journal.Pone.0226928 |
0.409 |
|
| 2020 |
Fernandes RA, Li C, Wang G, Yang X, Savvides CS, Glassman CR, Dong S, Luxenberg E, Sibener LV, Birnbaum ME, Benoist C, Mathis D, Garcia KC. Author response: Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo Elife. DOI: 10.7554/Elife.58463.Sa2 |
0.646 |
|
| 2020 |
Mendoza JL, Fischer S, Gee MH, Lam LH, Brackenridge S, Powrie FM, Birnbaum M, McMichael AJ, Garcia KC, Gillespie GM. Author response: Interrogating the recognition landscape of a conserved HIV-specific TCR reveals distinct bacterial peptide cross-reactivity Elife. DOI: 10.7554/Elife.58128.Sa2 |
0.737 |
|
| 2020 |
Tseng D, Chiou S, Yang X, Reuben A, Wilhelmy J, McSween A, Conley S, Sinha R, Nabet B, Wang C, Shrager JB, Berry MF, Backhus LM, Lui N, Wakelee HA, ... ... Garcia KC, et al. Discovery of a novel shared tumor antigen in human lung cancer. Journal of Clinical Oncology. 38: 3087-3087. DOI: 10.1200/Jco.2020.38.15_Suppl.3087 |
0.37 |
|
| 2019 |
Anton OM, Peterson ME, Hollander MJ, Dorward DW, Arora G, Traba J, Rajagopalan S, Snapp EL, Garcia KC, Waldmann TA, Long EO. -endocytosis of intact IL-15Rα-IL-15 complex from presenting cells into NK cells favors signaling for proliferation. Proceedings of the National Academy of Sciences of the United States of America. PMID 31871169 DOI: 10.1073/Pnas.1911678117 |
0.379 |
|
| 2019 |
Saligrama N, Zhao F, Sikora MJ, Serratelli WS, Fernandes RA, Louis DM, Yao W, Ji X, Idoyaga J, Mahajan VB, Steinmetz LM, Chien YH, Hauser SL, Oksenberg JR, Garcia KC, et al. Opposing T cell responses in experimental autoimmune encephalomyelitis. Nature. PMID 31391585 DOI: 10.1038/S41586-019-1467-X |
0.343 |
|
| 2019 |
Spangler JB, Moraga I, Jude KM, Savvides CS, Garcia KC. A strategy for the selection of monovalent antibodies that span protein dimer interfaces. The Journal of Biological Chemistry. PMID 31387945 DOI: 10.1074/Jbc.Ra119.009213 |
0.724 |
|
| 2019 |
Mendoza JL, Escalante NK, Jude KM, Sotolongo Bellon J, Su L, Horton TM, Tsutsumi N, Berardinelli SJ, Haltiwanger RS, Piehler J, Engleman EG, Garcia KC. Structure of the IFNγ receptor complex guides design of biased agonists. Nature. PMID 30814731 DOI: 10.1038/S41586-019-0988-7 |
0.656 |
|
| 2019 |
Silva DA, Yu S, Ulge UY, Spangler JB, Jude KM, Labão-Almeida C, Ali LR, Quijano-Rubio A, Ruterbusch M, Leung I, Biary T, Crowley SJ, Marcos E, Walkey CD, Weitzner BD, ... Garcia KC, et al. De novo design of potent and selective mimics of IL-2 and IL-15. Nature. 565: 186-191. PMID 30626941 DOI: 10.2210/Pdb6Dg5/Pdb |
0.691 |
|
| 2019 |
Wilmes S, Hafer M, Stanly TA, Moraga I, Vuorio J, Poojari C, Sharma V, Löchte S, Pulgar Prieto K, Tucker JA, Hubbard SR, Garcia K, Vattulainen I, Hitchcock I, Piehler J. New Paradigms for the Mechanisms of Thrombopoietin Receptor Activation and Dysregulation By the JAK2V617F Mutation Blood. 134: 2962-2962. DOI: 10.1182/Blood-2019-129234 |
0.362 |
|
| 2018 |
Pervolaraki K, Rastgou Talemi S, Albrecht D, Bormann F, Bamford C, Mendoza JL, Garcia KC, McLauchlan J, Höfer T, Stanifer ML, Boulant S. Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance. Plos Pathogens. 14: e1007420. PMID 30485383 DOI: 10.1371/Journal.Ppat.1007420 |
0.591 |
|
| 2018 |
Bamford CGG, Aranday-Cortes E, Filipe IC, Sukumar S, Mair D, Filipe ADS, Mendoza JL, Garcia KC, Fan S, Tishkoff SA, McLauchlan J. A polymorphic residue that attenuates the antiviral potential of interferon lambda 4 in hominid lineages. Plos Pathogens. 14: e1007307. PMID 30308076 DOI: 10.1371/Journal.Ppat.1007307 |
0.548 |
|
| 2018 |
Vallon M, Yuki K, Nguyen TD, Chang J, Yuan J, Siepe D, Miao Y, Essler M, Noda M, Garcia KC, Kuo CJ. A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Specific Regulation of Wnt Bioavailability. Cell Reports. 25: 339-349.e9. PMID 30304675 DOI: 10.1016/J.Celrep.2018.09.045 |
0.373 |
|
| 2018 |
Riley TP, Hellman LM, Gee MH, Mendoza JL, Alonso JA, Foley KC, Nishimura MI, Vander Kooi CW, Garcia KC, Baker BM. T cell receptor cross-reactivity expanded by dramatic peptide-MHC adaptability. Nature Chemical Biology. 14: 934-942. PMID 30224695 DOI: 10.1038/S41589-018-0130-4 |
0.653 |
|
| 2018 |
Spangler JB, Trotta E, Tomala J, Peck A, Young TA, Savvides CS, Silveria S, Votavova P, Salafsky J, Pande VS, Kovar M, Bluestone JA, Garcia KC. Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy. Journal of Immunology (Baltimore, Md. : 1950). PMID 30104245 DOI: 10.4049/Jimmunol.1800578 |
0.694 |
|
| 2018 |
Sibener LV, Fernandes RA, Kolawole EM, Carbone CB, Liu F, McAffee D, Birnbaum ME, Yang X, Su LF, Yu W, Dong S, Gee MH, Jude KM, Davis MM, Groves JT, ... Garcia KC, et al. Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding. Cell. 174: 672-687.e27. PMID 30053426 DOI: 10.1016/J.Cell.2018.06.017 |
0.733 |
|
| 2018 |
Gee MH, Sibener LV, Birnbaum ME, Jude KM, Yang X, Fernandes RA, Mendoza JL, Glassman CR, Garcia KC. Stress-testing the relationship between T cell receptor/peptide-MHC affinity and cross-reactivity using peptide velcro. Proceedings of the National Academy of Sciences of the United States of America. PMID 30021852 DOI: 10.1073/Pnas.1802746115 |
0.783 |
|
| 2018 |
Trotta E, Bessette PH, Silveria SL, Ely LK, Jude KM, Le DT, Holst CR, Coyle A, Potempa M, Lanier LL, Garcia KC, Crellin NK, Rondon IJ, Bluestone JA. A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism. Nature Medicine. PMID 29942088 DOI: 10.1038/S41591-018-0070-2 |
0.374 |
|
| 2018 |
Miles TF, Spiess K, Jude KM, Tsutsumi N, Burg JS, Ingram JR, Waghray D, Hjorto GM, Larsen O, Ploegh HL, Rosenkilde MM, Garcia KC. Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy. Elife. 7. PMID 29882741 DOI: 10.7554/Elife.35850 |
0.409 |
|
| 2018 |
Fraietta JA, Nobles CL, Sammons MA, Lundh S, Carty SA, Reich TJ, Cogdill AP, Morrissette JJD, DeNizio JE, Reddy S, Hwang Y, Gohil M, Kulikovskaya I, Nazimuddin F, Gupta M, ... Garcia KC, et al. Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells. Nature. PMID 29849141 DOI: 10.1038/S41586-018-0178-Z |
0.341 |
|
| 2018 |
Sockolosky JT, Trotta E, Parisi G, Picton L, Su LL, Le AC, Chhabra A, Silveria SL, George BM, King IC, Tiffany MR, Jude K, Sibener LV, Baker D, Shizuru JA, ... Garcia KC, et al. Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes. Science (New York, N.Y.). 359: 1037-1042. PMID 29496879 DOI: 10.1126/Science.Aar3246 |
0.42 |
|
| 2018 |
Schneider M, Kumar V, Nordstrøm LU, Feng L, Takeuchi H, Hao H, Luca VC, Garcia KC, Stanley P, Wu P, Haltiwanger RS. Inhibition of Delta-induced Notch signaling using fucose analogs. Nature Chemical Biology. 14: 65-71. PMID 29176671 DOI: 10.1038/Nchembio.2520 |
0.348 |
|
| 2017 |
Gee MH, Han A, Lofgren SM, Beausang JF, Mendoza JL, Birnbaum ME, Bethune MT, Fischer S, Yang X, Gomez-Eerland R, Bingham DB, Sibener LV, Fernandes RA, Velasco A, Baltimore D, ... Garcia KC, et al. Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes. Cell. PMID 29275860 DOI: 10.1016/J.Cell.2017.11.043 |
0.768 |
|
| 2017 |
Chheda ZS, Kohanbash G, Okada K, Jahan N, Sidney J, Pecoraro M, Yang X, Carrera DA, Downey KM, Shrivastav S, Liu S, Lin Y, Lagisetti C, Chuntova P, Watchmaker PB, ... Garcia KC, et al. Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy. The Journal of Experimental Medicine. PMID 29203539 DOI: 10.1084/Jem.20171046 |
0.352 |
|
| 2017 |
Carbone CB, Kern N, Fernandes RA, Hui E, Su X, Garcia KC, Vale RD. In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase. Proceedings of the National Academy of Sciences of the United States of America. PMID 29042512 DOI: 10.1073/Pnas.1710358114 |
0.408 |
|
| 2017 |
Ingram JR, Blomberg OS, Sockolosky JT, Ali L, Schmidt FI, Pishesha N, Espinosa C, Dougan SK, Garcia KC, Ploegh HL, Dougan M. Localized CD47 blockade enhances immunotherapy for murine melanoma. Proceedings of the National Academy of Sciences of the United States of America. PMID 28874561 DOI: 10.1073/Pnas.1710776114 |
0.313 |
|
| 2017 |
Li H, Watson A, Olechwier A, Anaya M, Sorooshyari SK, Harnett DP, Lee HP, Vielmetter J, Fares MA, Garcia KC, Özkan E, Labrador JP, Zinn K. Deconstruction of the Beaten Path-Sidestep interaction network provides insights into neuromuscular system development. Elife. 6. PMID 28829740 DOI: 10.7554/Elife.28111 |
0.682 |
|
| 2017 |
Richter D, Moraga I, Winkelmann H, Birkholz O, Wilmes S, Schulte M, Kraich M, Kenneweg H, Beutel O, Selenschik P, Paterok D, Gavutis M, Schmidt T, Garcia KC, Müller TD, et al. Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments. Nature Communications. 8: 15976. PMID 28706306 DOI: 10.1038/Ncomms15976 |
0.41 |
|
| 2017 |
Hilton HG, McMurtrey CP, Han AS, Djaoud Z, Guethlein LA, Blokhuis JH, Pugh JL, Goyos A, Horowitz A, Buchli R, Jackson KW, Bardet W, Bushnell DA, Robinson PJ, Mendoza JL, ... Garcia KC, et al. The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands. Cell Reports. 19: 1394-1405. PMID 28514659 DOI: 10.1016/J.Celrep.2017.04.059 |
0.737 |
|
| 2017 |
Moraga I, Spangler JB, Mendoza JL, Gakovic M, Wehrman TS, Krutzik P, Garcia KC. Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers. Elife. 6. PMID 28498099 DOI: 10.7554/Elife.22882 |
0.784 |
|
| 2017 |
Yan KS, Janda CY, Chang J, Zheng GXY, Larkin KA, Luca VC, Chia LA, Mah AT, Han A, Terry JM, Ootani A, Roelf K, Lee M, Yuan J, Li X, ... Garcia KC, et al. Non-equivalence of Wnt and R-spondin ligands during Lgr5(+) intestinal stem-cell self-renewal. Nature. PMID 28467820 DOI: 10.1038/Nature22313 |
0.479 |
|
| 2017 |
Janda CY, Dang LT, You C, Chang J, de Lau W, Zhong ZA, Yan KS, Marecic O, Siepe D, Li X, Moody JD, Williams BO, Clevers H, Piehler J, Baker D, ... Garcia KC, et al. Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling. Nature. PMID 28467818 DOI: 10.1038/Nature22306 |
0.36 |
|
| 2017 |
Mendoza JL, Schneider WM, Hoffmann HH, Vercauteren K, Jude KM, Xiong A, Moraga I, Horton TM, Glenn JS, de Jong YP, Rice CM, Garcia KC. The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity. Immunity. 46: 379-392. PMID 28329704 DOI: 10.1016/J.Immuni.2017.02.017 |
0.641 |
|
| 2017 |
Kim AR, Ulirsch JC, Wilmes S, Unal E, Moraga I, Karakukcu M, Yuan D, Kazerounian S, Abdulhay NJ, King DS, Gupta N, Gabriel SB, Lander ES, Patiroglu T, Ozcan A, ... Garcia KC, et al. Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation. Cell. 168: 1053-1064.e15. PMID 28283061 DOI: 10.1016/J.Cell.2017.02.026 |
0.377 |
|
| 2017 |
Ho CC, Chhabra A, Starkl P, Schnorr PJ, Wilmes S, Moraga I, Kwon HS, Gaudenzio N, Sibilano R, Wehrman TS, Gakovic M, Sockolosky JT, Tiffany MR, Ring AM, Piehler J, ... Garcia KC, et al. Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling. Cell. 168: 1041-1052.e18. PMID 28283060 DOI: 10.1016/J.Cell.2017.02.011 |
0.721 |
|
| 2017 |
Luca VC, Kim BC, Ge C, Kakuda S, Wu D, Roein-Peikar M, Haltiwanger RS, Zhu C, Ha T, Garcia KC. Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity. Science (New York, N.Y.). PMID 28254785 DOI: 10.1126/Science.Aaf9739 |
0.372 |
|
| 2017 |
Li H, Watson A, Olechwier A, Anaya M, Sorooshyari SK, Harnett DP, Lee H(, Vielmetter J, Fares MA, Garcia KC, Özkan E, Labrador J, Zinn K. Author response: Deconstruction of the beaten Path-Sidestep interaction network provides insights into neuromuscular system development Elife. DOI: 10.7554/Elife.28111.016 |
0.646 |
|
| 2017 |
Moraga I, Spangler JB, Mendoza JL, Gakovic M, Wehrman TS, Krutzik P, Garcia KC. Author response: Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers Elife. DOI: 10.7554/Elife.22882.019 |
0.749 |
|
| 2017 |
Riley TP, Mendoza J, Garcia KC, Baker BM. 2064 Journal of Clinical and Translational Science. 1: 54-55. DOI: 10.1017/cts.2017.195 |
0.589 |
|
| 2016 |
You C, Marquez-Lago TT, Richter CP, Wilmes S, Moraga I, Garcia KC, Leier A, Piehler J. Receptor dimer stabilization by hierarchical plasma membrane microcompartments regulates cytokine signaling. Science Advances. 2: e1600452. PMID 27957535 DOI: 10.1126/Sciadv.1600452 |
0.352 |
|
| 2016 |
Sharon E, Sibener LV, Battle A, Fraser HB, Garcia KC, Pritchard JK. Genetic variation in MHC proteins is associated with T cell receptor expression biases. Nature Genetics. PMID 27479906 DOI: 10.1038/Ng.3625 |
0.39 |
|
| 2016 |
Weiskopf K, Jahchan NS, Schnorr PJ, Cristea S, Ring AM, Maute RL, Volkmer AK, Volkmer JP, Liu J, Lim JS, Yang D, Seitz G, Nguyen T, Wu D, Jude K, ... Garcia KC, et al. CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer. The Journal of Clinical Investigation. PMID 27294525 DOI: 10.1172/Jci81603 |
0.694 |
|
| 2016 |
Sockolosky JT, Dougan M, Ingram JR, Ho CC, Kauke MJ, Almo SC, Ploegh HL, Garcia KC. Durable antitumor responses to CD47 blockade require adaptive immune stimulation. Proceedings of the National Academy of Sciences of the United States of America. PMID 27091975 DOI: 10.1073/Pnas.1604268113 |
0.31 |
|
| 2016 |
Ng CT, Mendoza JL, Garcia KC, Oldstone MB. Alpha and Beta Type 1 Interferon Signaling: Passage for Diverse Biologic Outcomes. Cell. 164: 349-352. PMID 26824652 DOI: 10.1016/J.Cell.2015.12.027 |
0.561 |
|
| 2016 |
Mathias MD, Sockolosky JT, Chang AY, Liu C, Garcia KC, Scheinberg DA. CD47 Blockade Enhances Therapeutic Activity of TCR Mimic Antibodies to Ultra-Low Density Cancer Epitopes through Cytokine Feed Forward Mechanisms Blood. 128: 4048-4048. DOI: 10.1182/Blood.V128.22.4048.4048 |
0.362 |
|
| 2016 |
Luca VC, Jude KM, Pierce NW, Nachury MV, Fischer S, Garcia KC. Abstract B068: Structural basis for Notch1 engagement of Delta-like 4 and Jagged1 Cancer Immunology Research. 4. DOI: 10.1158/2326-6074.Cricimteatiaacr15-B068 |
0.433 |
|
| 2015 |
Carrillo RA, Özkan E, Menon KP, Nagarkar-Jaiswal S, Lee PT, Jeon M, Birnbaum ME, Bellen HJ, Garcia KC, Zinn K. Control of Synaptic Connectivity by a Network of Drosophila IgSF Cell Surface Proteins. Cell. 163: 1770-82. PMID 26687361 DOI: 10.1016/J.Cell.2015.11.022 |
0.778 |
|
| 2015 |
Moraga I, Richter D, Wilmes S, Winkelmann H, Jude K, Thomas C, Suhoski MM, Engleman EG, Piehler J, Garcia KC. Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency. Science Signaling. 8: ra114. PMID 26554818 DOI: 10.1126/Scisignal.Aab2677 |
0.463 |
|
| 2015 |
Adams JJ, Narayanan S, Birnbaum ME, Sidhu SS, Blevins SJ, Gee MH, Sibener LV, Baker BM, Kranz DM, Garcia KC. Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity. Nature Immunology. PMID 26523866 DOI: 10.1038/Ni.3310 |
0.707 |
|
| 2015 |
Spiess K, Jeppesen MG, Malmgaard-Clausen M, Krzywkowski K, Dulal K, Cheng T, Hjortø GM, Larsen O, Burg JS, Jarvis MA, Garcia KC, Zhu H, Kledal TN, Rosenkilde MM. Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo. Proceedings of the National Academy of Sciences of the United States of America. PMID 26080445 DOI: 10.1073/Pnas.1509392112 |
0.363 |
|
| 2015 |
Mitra S, Ring AM, Amarnath S, Spangler JB, Li P, Ju W, Fischer S, Oh J, Spolski R, Weiskopf K, Kohrt H, Foley JE, Rajagopalan S, Long EO, Fowler DH, ... Garcia KC, et al. Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps. Immunity. 42: 826-38. PMID 25992859 DOI: 10.1016/J.Immuni.2015.04.018 |
0.792 |
|
| 2015 |
Spangler JB, Tomala J, Luca VC, Jude KM, Dong S, Ring AM, Votavova P, Pepper M, Kovar M, Garcia KC. Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms. Immunity. 42: 815-25. PMID 25992858 DOI: 10.1016/J.Immuni.2015.04.015 |
0.786 |
|
| 2015 |
Janda CY, Garcia KC. Wnt acylation and its functional implication in Wnt signalling regulation. Biochemical Society Transactions. 43: 211-6. PMID 25849919 DOI: 10.1042/Bst20140249 |
0.356 |
|
| 2015 |
Ho CC, Guo N, Sockolosky JT, Ring AM, Weiskopf K, Özkan E, Mori Y, Weissman IL, Garcia KC. "Velcro" engineering of high affinity CD47 ectodomain as signal regulatory protein α (SIRPα) antagonists that enhance antibody-dependent cellular phagocytosis. The Journal of Biological Chemistry. 290: 12650-63. PMID 25837251 DOI: 10.1074/Jbc.M115.648220 |
0.786 |
|
| 2015 |
Moraga I, Wernig G, Wilmes S, Gryshkova V, Richter CP, Hong WJ, Sinha R, Guo F, Fabionar H, Wehrman TS, Krutzik P, Demharter S, Plo I, Weissman IL, Minary P, ... Garcia KC, et al. Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands. Cell. 160: 1196-208. PMID 25728669 DOI: 10.1016/J.Cell.2015.02.011 |
0.526 |
|
| 2015 |
Luca VC, Jude KM, Pierce NW, Nachury MV, Fischer S, Garcia KC. Structural biology. Structural basis for Notch1 engagement of Delta-like 4. Science (New York, N.Y.). 347: 847-53. PMID 25700513 DOI: 10.1126/Science.1261093 |
0.358 |
|
| 2015 |
Birnbaum ME, Garcia KC. Self-determination in the T cell repertoire. Immunity. 42: 8-10. PMID 25607452 DOI: 10.1016/J.Immuni.2014.12.025 |
0.674 |
|
| 2015 |
Spangler JB, Moraga I, Mendoza JL, Garcia KC. Insights into cytokine-receptor interactions from cytokine engineering. Annual Review of Immunology. 33: 139-67. PMID 25493332 DOI: 10.1146/Annurev-Immunol-032713-120211 |
0.767 |
|
| 2015 |
Weiskopf K, Ring A, Garcia KC, Weissman I. CD47-blocking therapies stimulate macrophage cytokine secretion and are effective in a model of peritoneal carcinomatosis Journal For Immunotherapy of Cancer. 3. DOI: 10.1186/2051-1426-3-S2-P248 |
0.693 |
|
| 2014 |
Birnbaum ME, Berry R, Hsiao YS, Chen Z, Shingu-Vazquez MA, Yu X, Waghray D, Fischer S, McCluskey J, Rossjohn J, Walz T, Garcia KC. Molecular architecture of the αβ T cell receptor-CD3 complex. Proceedings of the National Academy of Sciences of the United States of America. 111: 17576-81. PMID 25422432 DOI: 10.1073/Pnas.1420936111 |
0.696 |
|
| 2014 |
Ardolino M, Azimi CS, Iannello A, Trevino TN, Horan L, Zhang L, Deng W, Ring AM, Fischer S, Garcia KC, Raulet DH. Cytokine therapy reverses NK cell anergy in MHC-deficient tumors. The Journal of Clinical Investigation. 124: 4781-94. PMID 25329698 DOI: 10.1172/Jci74337 |
0.671 |
|
| 2014 |
Birnbaum ME, Mendoza JL, Sethi DK, Dong S, Glanville J, Dobbins J, Ozkan E, Davis MM, Wucherpfennig KW, Garcia KC. Deconstructing the peptide-MHC specificity of T cell recognition. Cell. 157: 1073-87. PMID 24855945 DOI: 10.1016/J.Cell.2014.03.047 |
0.805 |
|
| 2014 |
Hawse WF, De S, Greenwood AI, Nicholson LK, Zajicek J, Kovrigin EL, Kranz DM, Garcia KC, Baker BM. TCR scanning of peptide/MHC through complementary matching of receptor and ligand molecular flexibility. Journal of Immunology (Baltimore, Md. : 1950). 192: 2885-91. PMID 24523505 DOI: 10.4049/Jimmunol.1302953 |
0.316 |
|
| 2014 |
Özkan E, Chia PH, Wang RR, Goriatcheva N, Borek D, Otwinowski Z, Walz T, Shen K, Garcia KC. Extracellular architecture of the SYG-1/SYG-2 adhesion complex instructs synaptogenesis. Cell. 156: 482-94. PMID 24485456 DOI: 10.1016/J.Cell.2014.01.004 |
0.693 |
|
| 2014 |
Moraga I, Spangler J, Mendoza JL, Garcia KC. Multifarious determinants of cytokine receptor signaling specificity. Advances in Immunology. 121: 1-39. PMID 24388212 DOI: 10.1016/B978-0-12-800100-4.00001-5 |
0.781 |
|
| 2013 |
Weiskopf K, Ring AM, Schnorr PJ, Volkmer JP, Volkmer AK, Weissman IL, Garcia KC. Improving macrophage responses to therapeutic antibodies by molecular engineering of SIRPα variants. Oncoimmunology. 2: e25773. PMID 24319639 DOI: 10.4161/Onci.25773 |
0.709 |
|
| 2013 |
Kruse AC, Ring AM, Manglik A, Hu J, Hu K, Eitel K, Hübner H, Pardon E, Valant C, Sexton PM, Christopoulos A, Felder CC, Gmeiner P, Steyaert J, Weis WI, Garcia KC, et al. Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature. 504: 101-6. PMID 24256733 DOI: 10.1038/Nature12735 |
0.701 |
|
| 2013 |
Ring AM, Manglik A, Kruse AC, Enos MD, Weis WI, Garcia KC, Kobilka BK. Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody. Nature. 502: 575-9. PMID 24056936 DOI: 10.1038/Nature12572 |
0.698 |
|
| 2013 |
Kim T, Vidal GS, Djurisic M, William CM, Birnbaum ME, Garcia KC, Hyman BT, Shatz CJ. Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model. Science (New York, N.Y.). 341: 1399-404. PMID 24052308 DOI: 10.1126/Science.1242077 |
0.733 |
|
| 2013 |
Özkan E, Carrillo RA, Eastman CL, Weiszmann R, Waghray D, Johnson KG, Zinn K, Celniker SE, Garcia KC. An extracellular interactome of immunoglobulin and LRR proteins reveals receptor-ligand networks. Cell. 154: 228-39. PMID 23827685 DOI: 10.1016/J.Cell.2013.06.006 |
0.36 |
|
| 2013 |
Weiskopf K, Ring AM, Ho CC, Volkmer JP, Levin AM, Volkmer AK, Ozkan E, Fernhoff NB, van de Rijn M, Weissman IL, Garcia KC. Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies. Science (New York, N.Y.). 341: 88-91. PMID 23722425 DOI: 10.1126/Science.1238856 |
0.79 |
|
| 2013 |
Yu XM, Gutman I, Mosca TJ, Iram T, Ozkan E, Garcia KC, Luo L, Schuldiner O. Plum, an immunoglobulin superfamily protein, regulates axon pruning by facilitating TGF-β signaling. Neuron. 78: 456-68. PMID 23664613 DOI: 10.1016/J.Neuron.2013.03.004 |
0.663 |
|
| 2013 |
Sitrin J, Ring A, Garcia KC, Benoist C, Mathis D. Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2. The Journal of Experimental Medicine. 210: 1153-65. PMID 23650440 DOI: 10.1084/Jem.20122248 |
0.69 |
|
| 2013 |
Hou J, Townson SA, Kovalchin JT, Masci A, Kiner O, Shu Y, King BM, Schirmer E, Golden K, Thomas C, Garcia KC, Zarbis-Papastoitsis G, Furfine ES, Barnes TM. Design of a superior cytokine antagonist for topical ophthalmic use. Proceedings of the National Academy of Sciences of the United States of America. 110: 3913-8. PMID 23431173 DOI: 10.1073/Pnas.1217996110 |
0.366 |
|
| 2013 |
Garcia KC, Ring A, Lin J, Levin A, Pande V, Bowman G, Craig K, Boyman O, Lin P. Probing the Relationship between Extracellular Ligand Recognition and Cytokine Receptor Activation with Structural Biology and Protein Engineering Biophysical Journal. 104: 45a. DOI: 10.1016/J.Bpj.2012.11.285 |
0.732 |
|
| 2012 |
Ring AM, Lin JX, Feng D, Mitra S, Rickert M, Bowman GR, Pande VS, Li P, Moraga I, Spolski R, Ozkan E, Leonard WJ, Garcia KC. Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15. Nature Immunology. 13: 1187-95. PMID 23104097 DOI: 10.1038/Ni.2449 |
0.788 |
|
| 2012 |
Junttila IS, Creusot RJ, Moraga I, Bates DL, Wong MT, Alonso MN, Suhoski MM, Lupardus P, Meier-Schellersheim M, Engleman EG, Utz PJ, Fathman CG, Paul WE, Garcia KC. Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines. Nature Chemical Biology. 8: 990-8. PMID 23103943 DOI: 10.1038/Nchembio.1096 |
0.421 |
|
| 2012 |
Birnbaum ME, Dong S, Garcia KC. Diversity-oriented approaches for interrogating T-cell receptor repertoire, ligand recognition, and function. Immunological Reviews. 250: 82-101. PMID 23046124 DOI: 10.1111/Imr.12006 |
0.728 |
|
| 2012 |
Garcia KC. Insights into immune structure, recognition, and signaling. Immunological Reviews. 250: 5-9. PMID 23046119 DOI: 10.1111/Imr.12007 |
0.416 |
|
| 2012 |
Bazan JF, Janda CY, Garcia KC. Structural architecture and functional evolution of Wnts. Developmental Cell. 23: 227-32. PMID 22898770 DOI: 10.1016/J.Devcel.2012.07.011 |
0.356 |
|
| 2012 |
Garcia KC. Reconciling views on T cell receptor germline bias for MHC. Trends in Immunology. 33: 429-36. PMID 22771140 DOI: 10.1016/J.It.2012.05.005 |
0.438 |
|
| 2012 |
Garcia KC, Gapin L, Adams JJ, Birnbaum ME, Scott-Browne JP, Kappler JW, Marrack P. A closer look at TCR germline recognition. Immunity. 36: 887-8. PMID 22705103 DOI: 10.1016/J.Immuni.2012.05.018 |
0.673 |
|
| 2012 |
Janda CY, Waghray D, Levin AM, Thomas C, Garcia KC. Structural basis of Wnt recognition by Frizzled. Science (New York, N.Y.). 337: 59-64. PMID 22653731 DOI: 10.1126/Science.1222879 |
0.338 |
|
| 2012 |
Levin AM, Bates DL, Ring AM, Krieg C, Lin JT, Su L, Moraga I, Raeber ME, Bowman GR, Novick P, Pande VS, Fathman CG, Boyman O, Garcia KC. Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'. Nature. 484: 529-33. PMID 22446627 DOI: 10.1038/Nature10975 |
0.699 |
|
| 2012 |
Thomas C, Bazan JF, Garcia KC. Structure of the activating IL-1 receptor signaling complex. Nature Structural & Molecular Biology. 19: 455-7. PMID 22426547 DOI: 10.1038/Nsmb.2260 |
0.428 |
|
| 2012 |
Collison LW, Delgoffe GM, Guy CS, Vignali KM, Chaturvedi V, Fairweather D, Satoskar AR, Garcia KC, Hunter CA, Drake CG, Murray PJ, Vignali DA. The composition and signaling of the IL-35 receptor are unconventional. Nature Immunology. 13: 290-9. PMID 22306691 DOI: 10.1038/Ni.2227 |
0.398 |
|
| 2011 |
Adams JJ, Narayanan S, Liu B, Birnbaum ME, Kruse AC, Bowerman NA, Chen W, Levin AM, Connolly JM, Zhu C, Kranz DM, Garcia KC. T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex. Immunity. 35: 681-93. PMID 22101157 DOI: 10.1016/J.Immuni.2011.09.013 |
0.723 |
|
| 2011 |
Thomas C, Moraga I, Levin D, Krutzik PO, Podoplelova Y, Trejo A, Lee C, Yarden G, Vleck SE, Glenn JS, Nolan GP, Piehler J, Schreiber G, Garcia KC. Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell. 146: 621-32. PMID 21854986 DOI: 10.1016/J.Cell.2011.06.048 |
0.425 |
|
| 2011 |
Rogers CJ, Clark PM, Tully SE, Abrol R, Garcia KC, Goddard WA, Hsieh-Wilson LC. Elucidating glycosaminoglycan-protein-protein interactions using carbohydrate microarray and computational approaches. Proceedings of the National Academy of Sciences of the United States of America. 108: 9747-52. PMID 21628576 DOI: 10.1073/Pnas.1102962108 |
0.33 |
|
| 2011 |
Newell EW, Ely LK, Kruse AC, Reay PA, Rodriguez SN, Lin AE, Kuhns MS, Garcia KC, Davis MM. Structural basis of specificity and cross-reactivity in T cell receptors specific for cytochrome c-I-E(k). Journal of Immunology (Baltimore, Md. : 1950). 186: 5823-32. PMID 21490152 DOI: 10.4049/Jimmunol.1100197 |
0.416 |
|
| 2011 |
Shen A, Lupardus PJ, Gersch MM, Puri AW, Albrow VE, Garcia KC, Bogyo M. Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins. Nature Structural & Molecular Biology. 18: 364-71. PMID 21317893 DOI: 10.1038/Nsmb.1990 |
0.326 |
|
| 2011 |
Lupardus PJ, Skiniotis G, Rice AJ, Thomas C, Fischer S, Walz T, Garcia KC. Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex. Structure (London, England : 1993). 19: 45-55. PMID 21220115 DOI: 10.1016/J.Str.2010.10.010 |
0.408 |
|
| 2011 |
Gleimer M, Wahl AR, Hickman HD, Abi-Rached L, Norman PJ, Guethlein LA, Hammond JA, Draghi M, Adams EJ, Juo S, Jalili R, Gharizadeh B, Ronaghi M, Garcia KC, Hildebrand WH, et al. Although divergent in residues of the peptide binding site, conserved chimpanzee Patr-AL and polymorphic human HLA-A*02 have overlapping peptide-binding repertoires. Journal of Immunology (Baltimore, Md. : 1950). 186: 1575-88. PMID 21209280 DOI: 10.4049/Jimmunol.1002990 |
0.308 |
|
| 2010 |
Garcia KC, Degano M, Stanfield RL, Brunmark A, Jackson MR, Peterson PA, Teyton L, Wilson IA. An αß T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. Science. 1996. 274: 209-219. Journal of Immunology (Baltimore, Md. : 1950). 185: 6402-12. PMID 21084669 |
0.447 |
|
| 2010 |
Liu H, Juo ZS, Shim AH, Focia PJ, Chen X, Garcia KC, He X. Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1. Cell. 142: 749-61. PMID 20727575 DOI: 10.1016/J.Cell.2010.07.040 |
0.375 |
|
| 2010 |
Juang J, Ebert PJ, Feng D, Garcia KC, Krogsgaard M, Davis MM. Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection. The Journal of Experimental Medicine. 207: 1223-34. PMID 20457759 DOI: 10.1084/Jem.20092170 |
0.38 |
|
| 2010 |
Lupardus PJ, Birnbaum ME, Garcia KC. Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2. Structure (London, England : 1993). 18: 332-42. PMID 20223216 DOI: 10.1016/J.Str.2010.01.003 |
0.703 |
|
| 2010 |
Kuhns MS, Girvin AT, Klein LO, Chen R, Jensen KD, Newell EW, Huppa JB, Lillemeier BF, Huse M, Chien YH, Garcia KC, Davis MM. Evidence for a functional sidedness to the alphabetaTCR. Proceedings of the National Academy of Sciences of the United States of America. 107: 5094-9. PMID 20202921 DOI: 10.1073/Pnas.1000925107 |
0.384 |
|
| 2010 |
Feng D, Kim T, Ozkan E, Light M, Torkin R, Teng KK, Hempstead BL, Garcia KC. Molecular and structural insight into proNGF engagement of p75NTR and sortilin. Journal of Molecular Biology. 396: 967-84. PMID 20036257 DOI: 10.1016/J.Jmb.2009.12.030 |
0.722 |
|
| 2010 |
Garcia KC, Degano M, Stanfield RL, Brunmark A, Jackson MR, Peterson PA, Teyton L, Wilson IA. An αβ T cell receptor structure at 2.5 Å and its orientation in the TCR-MHC complex Journal of Immunology. 185: 209-219. DOI: 10.1126/science.274.5285.209 |
0.452 |
|
| 2009 |
Landais E, Romagnoli PA, Corper AL, Shires J, Altman JD, Wilson IA, Garcia KC, Teyton L. New design of MHC class II tetramers to accommodate fundamental principles of antigen presentation. Journal of Immunology (Baltimore, Md. : 1950). 183: 7949-57. PMID 19923463 DOI: 10.4049/Jimmunol.0902493 |
0.512 |
|
| 2009 |
Ely LK, Fischer S, Garcia KC. Structural basis of receptor sharing by interleukin 17 cytokines. Nature Immunology. 10: 1245-51. PMID 19838198 DOI: 10.1038/Ni.1813 |
0.409 |
|
| 2009 |
Eroglu C, Allen NJ, Susman MW, O'Rourke NA, Park CY, Ozkan E, Chakraborty C, Mulinyawe SB, Annis DS, Huberman AD, Green EM, Lawler J, Dolmetsch R, Garcia KC, Smith SJ, et al. Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. Cell. 139: 380-92. PMID 19818485 DOI: 10.1016/J.Cell.2009.09.025 |
0.688 |
|
| 2009 |
Bowerman NA, Colf LA, Garcia KC, Kranz DM. Different strategies adopted by K(b) and L(d) to generate T cell specificity directed against their respective bound peptides. The Journal of Biological Chemistry. 284: 32551-61. PMID 19755422 DOI: 10.1074/Jbc.M109.040501 |
0.793 |
|
| 2009 |
Ito T, Suzuki S, Kanaji S, Shiraishi H, Ohta S, Arima K, Tanaka G, Tamada T, Honjo E, Garcia KC, Kuroki R, Izuhara K. Distinct structural requirements for interleukin-4 (IL-4) and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsiveness. The Journal of Biological Chemistry. 284: 24289-96. PMID 19586918 DOI: 10.1074/Jbc.M109.007286 |
0.389 |
|
| 2009 |
Shen A, Lupardus PJ, Albrow VE, Guzzetta A, Powers JC, Garcia KC, Bogyo M. Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin. Nature Chemical Biology. 5: 469-78. PMID 19465933 DOI: 10.1038/Nchembio.178 |
0.317 |
|
| 2009 |
Garcia KC, Adams JJ, Feng D, Ely LK. The molecular basis of TCR germline bias for MHC is surprisingly simple. Nature Immunology. 10: 143-7. PMID 19148199 DOI: 10.1038/Ni.F.219 |
0.411 |
|
| 2009 |
Wang X, Lupardus P, Laporte SL, Garcia KC. Structural biology of shared cytokine receptors. Annual Review of Immunology. 27: 29-60. PMID 18817510 DOI: 10.1146/Annurev.Immunol.24.021605.090616 |
0.546 |
|
| 2009 |
Liu CW, Alekseyev VY, Allwardt JR, Bankovich AJ, Cade-Menun BJ, Davis RW, Du LS, Garcia KC, Herschlag D, Khosla C, Kraut DA, Li Q, Null B, Puglisi JD, Sigala PA, et al. The diversity of nuclear magnetic resonance spectroscopy Nato Science For Peace and Security Series B: Physics and Biophysics. 65-81. |
0.642 |
|
| 2008 |
Jones LL, Colf LA, Bankovich AJ, Stone JD, Gao YG, Chan CM, Huang RH, Garcia KC, Kranz DM. Different thermodynamic binding mechanisms and peptide fine specificities associated with a panel of structurally similar high-affinity T cell receptors. Biochemistry. 47: 12398-408. PMID 18973345 DOI: 10.1021/Bi801349G |
0.798 |
|
| 2008 |
Jones LL, Colf LA, Stone JD, Garcia KC, Kranz DM. Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation. Journal of Immunology (Baltimore, Md. : 1950). 181: 6255-64. PMID 18941216 DOI: 10.4049/Jimmunol.181.9.6255 |
0.784 |
|
| 2008 |
Dukkipati A, Park HH, Waghray D, Fischer S, Garcia KC. BacMam system for high-level expression of recombinant soluble and membrane glycoproteins for structural studies. Protein Expression and Purification. 62: 160-70. PMID 18782620 DOI: 10.1016/J.Pep.2008.08.004 |
0.31 |
|
| 2008 |
Skiniotis G, Lupardus PJ, Martick M, Walz T, Garcia KC. Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex. Molecular Cell. 31: 737-48. PMID 18775332 DOI: 10.1016/J.Molcel.2008.08.011 |
0.407 |
|
| 2008 |
Lupardus PJ, Garcia KC. The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12. Journal of Molecular Biology. 382: 931-41. PMID 18680750 DOI: 10.1016/J.Jmb.2008.07.051 |
0.372 |
|
| 2008 |
Adams EJ, Strop P, Shin S, Chien YH, Garcia KC. An autonomous CDR3delta is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by gammadelta T cells. Nature Immunology. 9: 777-84. PMID 18516039 DOI: 10.1038/Ni.1620 |
0.372 |
|
| 2008 |
LaPorte SL, Juo ZS, Vaclavikova J, Colf LA, Qi X, Heller NM, Keegan AD, Garcia KC. Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system. Cell. 132: 259-72. PMID 18243101 DOI: 10.1016/j.cell.2007.12.030 |
0.779 |
|
| 2007 |
Colf LA, Juo ZS, Garcia KC. Structure of the measles virus hemagglutinin. Nature Structural & Molecular Biology. 14: 1227-8. PMID 18026116 DOI: 10.1038/Nsmb1342 |
0.773 |
|
| 2007 |
Rinderknecht CH, Belmares MP, Catanzarite TL, Bankovich AJ, Holmes TH, Garcia KC, Nanda NK, Busch R, Kovats S, Mellins ED. Posttranslational regulation of I-Ed by affinity for CLIP. Journal of Immunology (Baltimore, Md. : 1950). 179: 5907-15. PMID 17947664 DOI: 10.4049/Jimmunol.179.9.5907 |
0.731 |
|
| 2007 |
Feng D, Bond CJ, Ely LK, Maynard J, Garcia KC. Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'. Nature Immunology. 8: 975-83. PMID 17694060 DOI: 10.1038/Ni1502 |
0.384 |
|
| 2007 |
Varani L, Bankovich AJ, Liu CW, Colf LA, Jones LL, Kranz DM, Puglisi JD, Garcia KC. Solution mapping of T cell receptor docking footprints on peptide-MHC. Proceedings of the National Academy of Sciences of the United States of America. 104: 13080-5. PMID 17670943 DOI: 10.1073/Pnas.0703702104 |
0.812 |
|
| 2007 |
Hanick NA, Rickert M, Varani L, Bankovich AJ, Cochran JR, Kim DM, Surh CD, Garcia KC. Elucidation of the interleukin-15 binding site on its alpha receptor by NMR. Biochemistry. 46: 9453-61. PMID 17655329 DOI: 10.1021/Bi700652F |
0.749 |
|
| 2007 |
Adams EJ, Juo ZS, Venook RT, Boulanger MJ, Arase H, Lanier LL, Garcia KC. Structural elucidation of the m157 mouse cytomegalovirus ligand for Ly49 natural killer cell receptors. Proceedings of the National Academy of Sciences of the United States of America. 104: 10128-33. PMID 17537914 DOI: 10.1073/Pnas.0703735104 |
0.398 |
|
| 2007 |
Bankovich AJ, Raunser S, Juo ZS, Walz T, Davis MM, Garcia KC. Structural insight into pre-B cell receptor function. Science (New York, N.Y.). 316: 291-4. PMID 17431183 DOI: 10.1126/Science.1139412 |
0.733 |
|
| 2007 |
Colf LA, Bankovich AJ, Hanick NA, Bowerman NA, Jones LL, Kranz DM, Garcia KC. How a single T cell receptor recognizes both self and foreign MHC. Cell. 129: 135-46. PMID 17418792 DOI: 10.1016/J.Cell.2007.01.048 |
0.808 |
|
| 2007 |
Wucherpfennig KW, Allen PM, Celada F, Cohen IR, De Boer R, Garcia KC, Goldstein B, Greenspan R, Hafler D, Hodgkin P, Huseby ES, Krakauer DC, Nemazee D, Perelson AS, Pinilla C, et al. Polyspecificity of T cell and B cell receptor recognition. Seminars in Immunology. 19: 216-24. PMID 17398114 DOI: 10.1016/J.Smim.2007.02.012 |
0.402 |
|
| 2007 |
Wehrman T, He X, Raab B, Dukipatti A, Blau H, Garcia KC. Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors. Neuron. 53: 25-38. PMID 17196528 DOI: 10.1016/J.Neuron.2006.09.034 |
0.336 |
|
| 2006 |
Dukkipati A, Vaclavikova J, Waghray D, Garcia KC. In vitro reconstitution and preparative purification of complexes between the chemokine receptor CXCR4 and its ligands SDF-1alpha, gp120-CD4 and AMD3100. Protein Expression and Purification. 50: 203-14. PMID 16962791 DOI: 10.1016/J.Pep.2006.07.016 |
0.407 |
|
| 2006 |
He XL, Dukkipati A, Garcia KC. Structural determinants of natriuretic peptide receptor specificity and degeneracy. Journal of Molecular Biology. 361: 698-714. PMID 16870210 DOI: 10.1016/J.Jmb.2006.06.060 |
0.412 |
|
| 2006 |
Jones LL, Brophy SE, Bankovich AJ, Colf LA, Hanick NA, Garcia KC, Kranz DM. Engineering and characterization of a stabilized alpha1/alpha2 module of the class I major histocompatibility complex product Ld. The Journal of Biological Chemistry. 281: 25734-44. PMID 16815841 DOI: 10.1074/Jbc.M604343200 |
0.792 |
|
| 2006 |
Wang X, Baloh RH, Milbrandt J, Garcia KC. Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors. Structure (London, England : 1993). 14: 1083-92. PMID 16765900 DOI: 10.1016/J.Str.2006.05.010 |
0.536 |
|
| 2006 |
Kuhns MS, Davis MM, Garcia KC. Deconstructing the form and function of the TCR/CD3 complex. Immunity. 24: 133-9. PMID 16473826 DOI: 10.1016/J.Immuni.2006.01.006 |
0.373 |
|
| 2005 |
Wang X, Rickert M, Garcia KC. Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors. Science (New York, N.Y.). 310: 1159-63. PMID 16293754 DOI: 10.1126/Science.1117893 |
0.511 |
|
| 2005 |
Maynard J, Adams EJ, Krogsgaard M, Petersson K, Liu CW, Garcia KC. High-level bacterial secretion of single-chain αβ T-cell receptors Journal of Immunological Methods. 306: 51-67. PMID 16198365 DOI: 10.1016/J.Jim.2005.07.022 |
0.385 |
|
| 2005 |
Garcia KC, Adams EJ. How the T cell receptor sees antigen - A structural view Cell. 122: 333-336. PMID 16096054 DOI: 10.1016/J.Cell.2005.07.015 |
0.451 |
|
| 2005 |
Rickert M, Wang X, Boulanger MJ, Goriatcheva N, Garcia KC. The structure of interleukin-2 complexed with its alpha receptor. Science (New York, N.Y.). 308: 1477-80. PMID 15933202 DOI: 10.1126/Science.1109745 |
0.534 |
|
| 2005 |
He XL, Dukkipati A, Wang X, Garcia KC. A new paradigm for hormone recognition and allosteric receptor activation revealed from structural studies of NPR-C. Peptides. 26: 1035-43. PMID 15911071 DOI: 10.1016/J.Peptides.2004.08.035 |
0.513 |
|
| 2005 |
Skiniotis G, Boulanger MJ, Garcia KC, Walz T. Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor. Nature Structural & Molecular Biology. 12: 545-51. PMID 15895091 DOI: 10.1038/Nsmb941 |
0.439 |
|
| 2005 |
Shin S, El-Diwany R, Schaffert S, Adams EJ, Garcia KC, Pereira P, Chien YH. Antigen recognition determinants of γδ T cell receptors Science. 308: 252-255. PMID 15821090 DOI: 10.1126/Science.1106480 |
0.4 |
|
| 2005 |
Adams EJ, Chien YH, Garcia KC. Structure of a γδ T cell receptor in complex with the nonclassical MHC T22 Science. 308: 227-231. PMID 15821084 DOI: 10.1126/Science.1106885 |
0.445 |
|
| 2005 |
Maynard J, Petersson K, Wilson DH, Adams EJ, Blondelle SE, Boulanger MJ, Wilson DB, Garcia KC. Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity. Immunity. 22: 81-92. PMID 15664161 DOI: 10.1016/J.Immuni.2004.11.015 |
0.436 |
|
| 2005 |
Park JB, Yiu GC, Kaneko S, Wang J, Chang J, He XL, Garcia KC, He Z. Erratum: A TNF receptor family member, TROY, is a coreceptor with nogo receptor in mediating the inhibitory activity of myelin inhibitors (Neuron (February 3, 2005) 45: 3 (345-351)) Neuron. 45. DOI: 10.1016/J.Neuron.2005.02.015 |
0.307 |
|
| 2004 |
Boulanger MJ, Garcia KC. Shared cytokine signaling receptors: structural insights from the gp130 system. Advances in Protein Chemistry. 68: 107-46. PMID 15500860 DOI: 10.1016/S0065-3233(04)68004-1 |
0.42 |
|
| 2004 |
Strop P, Bankovich AJ, Hansen KC, Garcia KC, Brunger AT. Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family. Journal of Molecular Biology. 343: 1055-65. PMID 15476821 DOI: 10.1016/J.Jmb.2004.09.003 |
0.705 |
|
| 2004 |
Rickert M, Boulanger MJ, Goriatcheva N, Garcia KC. Compensatory energetic mechanisms mediating the assembly of signaling complexes between interleukin-2 and its alpha, beta, and gamma(c) receptors. Journal of Molecular Biology. 339: 1115-28. PMID 15178252 DOI: 10.1016/J.Jmb.2004.04.038 |
0.427 |
|
| 2004 |
He XL, Garcia KC. Structure of Nerve Growth Factor Complexed with the Shared Neurotrophin Receptor p75 Science. 304: 870-875. PMID 15131306 DOI: 10.1126/Science.1095190 |
0.337 |
|
| 2004 |
Wilson DB, Wilson DH, Schroder K, Pinilla C, Blondelle S, Houghten RA, Garcia KC. Specificity and degeneracy of T cells. Molecular Immunology. 40: 1047-55. PMID 15036909 DOI: 10.1016/J.Molimm.2003.11.022 |
0.383 |
|
| 2004 |
Bankovich AJ, Girvin AT, Moesta AK, Garcia KC. Peptide register shifting within the MHC groove: theory becomes reality. Molecular Immunology. 40: 1033-9. PMID 15036907 DOI: 10.1016/J.Molimm.2003.11.016 |
0.752 |
|
| 2004 |
Boulanger MJ, Chow DC, Brevnova E, Martick M, Sandford G, Nicholas J, Garcia KC. Molecular mechanisms for viral mimicry of a human cytokine: activation of gp130 by HHV-8 interleukin-6. Journal of Molecular Biology. 335: 641-54. PMID 14672670 DOI: 10.1016/J.Jmb.2003.10.070 |
0.412 |
|
| 2003 |
Krogsgaard M, Prado N, Adams EJ, He XL, Chow DC, Wilson DB, Garcia KC, Davis MM. Evidence that Structural Rearrangements and/or Flexibility during TCR Binding Can Contribute to T Cell Activation Molecular Cell. 12: 1367-1378. PMID 14690592 DOI: 10.1016/S1097-2765(03)00474-X |
0.411 |
|
| 2003 |
Boulanger MJ, Bankovich AJ, Kortemme T, Baker D, Garcia KC. Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130. Molecular Cell. 12: 577-89. PMID 14527405 DOI: 10.1016/S1097-2765(03)00365-4 |
0.742 |
|
| 2003 |
Boulanger MJ, Chow DC, Brevnova EE, Garcia KC. Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex. Science (New York, N.Y.). 300: 2101-4. PMID 12829785 DOI: 10.1126/Science.1083901 |
0.401 |
|
| 2003 |
He XL, Bazan JF, McDermott G, Park JB, Wang K, Tessier-Lavigne M, He Z, Garcia KC. Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibition. Neuron. 38: 177-85. PMID 12718853 DOI: 10.1016/S0896-6273(03)00232-0 |
0.348 |
|
| 2003 |
Bankovich AJ, Garcia KC. Not just any T cell receptor will do. Immunity. 18: 7-11. PMID 12530971 DOI: 10.1016/S1074-7613(02)00517-4 |
0.742 |
|
| 2002 |
Adams EJ, Garcia KC. A T cell receptor goes public Structure. 10: 1468-1469. PMID 12429085 DOI: 10.1016/S0969-2126(02)00890-0 |
0.396 |
|
| 2002 |
Chow DC, Brevnova L, He XL, Martick MM, Bankovich A, Garcia KC. A structural template for gp130-cytokine signaling assemblies. Biochimica Et Biophysica Acta. 1592: 225-35. PMID 12421668 DOI: 10.1016/S0167-4889(02)00317-8 |
0.744 |
|
| 2002 |
Wu LC, Tuot DS, Lyons DS, Garcia KC, Davis MM. Two-step binding mechanism for T-cell receptor recognition of peptide MHC. Nature. 418: 552-6. PMID 12152083 DOI: 10.1038/Nature00920 |
0.418 |
|
| 2002 |
He XL, Radu C, Sidney J, Sette A, Ward ES, Garcia KC. Structural snapshot of aberrant antigen presentation linked to autoimmunity: The immunodominant epitope of MBP complexed with I-Au Immunity. 17: 83-94. PMID 12150894 DOI: 10.1016/S1074-7613(02)00340-0 |
0.382 |
|
| 2002 |
He XL, Grigg ME, Boothroyd JC, Garcia KC. Structure of the immunodominant surface antigen from the Toxoplasma gondii SRS superfamily. Nature Structural Biology. 9: 606-11. PMID 12091874 DOI: 10.1038/Nsb819 |
0.314 |
|
| 2002 |
Busch R, Pashine A, Garcia KC, Mellins ED. Stabilization of soluble, low-affinity HLA-DM/HLA-DR1 complexes by leucine zippers Journal of Immunological Methods. 263: 111-121. PMID 12009208 DOI: 10.1016/S0022-1759(02)00034-0 |
0.384 |
|
| 2002 |
Luz JG, Huang M, Garcia KC, Rudolph MG, Apostolopoulos V, Teyton L, Wilson IA. Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) Interactions. The Journal of Experimental Medicine. 195: 1175-86. PMID 11994422 DOI: 10.1084/Jem.20011644 |
0.499 |
|
| 2001 |
He XL, Tabaczewski P, Ho J, Stroynowski I, Garcia KC. Promiscuous antigen presentation by the nonclassical MHC Ib Qa-2 is enabled by a shallow, hydrophobic groove and self-stabilized peptide conformation Structure. 9: 1213-1224. PMID 11738047 DOI: 10.1016/S0969-2126(01)00689-X |
0.362 |
|
| 2001 |
He Xl, Chow Dc, Martick MM, Garcia KC. Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone. Science (New York, N.Y.). 293: 1657-62. PMID 11533490 DOI: 10.1126/Science.1062246 |
0.41 |
|
| 2001 |
Ruiz PJ, DeVoss JJ, Nguyen LV, Fontoura PP, Hirschberg DL, Mitchell DJ, Garcia KC, Steinman L. Immunomodulation of experimental autoimmune encephalomyelitis with ordered peptides based on MHC-TCR binding motifs. Journal of Immunology (Baltimore, Md. : 1950). 167: 2688-93. PMID 11509612 DOI: 10.4049/Jimmunol.167.5.2688 |
0.354 |
|
| 2001 |
Chow DC, Ho J, Nguyen Pham TL, Rose-John S, Garcia KC. In Vitro reconstitution of recognition and activation complexes between interleukin-6 and gp130 Biochemistry. 40: 7593-7603. PMID 11412113 DOI: 10.1021/Bi010192Q |
0.399 |
|
| 2001 |
Garcia KC, Radu CG, Ho J, Ober RJ, Sally Ward E. Kinetics and thermodynamics of T cell receptor-autoantigen interactions in murine experimental autoimmune encephalomyelitis Proceedings of the National Academy of Sciences of the United States of America. 98: 6818-6823. PMID 11391002 DOI: 10.1073/Pnas.111161198 |
0.428 |
|
| 2000 |
Corper AL, Stratmann T, Apostolopoulos V, Scott CA, Garcia KC, Kang AS, Wilson IA, Teyton L. A structural framework for deciphering the link between I-A(g7) and autoimmune diabetes Science. 288: 505-511. PMID 10775108 DOI: 10.1126/Science.288.5465.505 |
0.39 |
|
| 2000 |
Degano M, Garcia KC, Apostolopoulos V, Rudolph MG, Teyton L, Wilson IA. A functional hot spot for antigen recognition in a superagonist TCR/MHC complex. Immunity. 12: 251-61. PMID 10755612 DOI: 10.1016/S1074-7613(00)80178-8 |
0.559 |
|
| 1999 |
Garcia KC, Degano M, Speir JA, Wilson IA. Emerging principles for T cell receptor recognition of antigen in cellular immunity. Reviews in Immunogenetics. 1: 75-90. PMID 11256574 |
0.357 |
|
| 1999 |
Garcia KC. Molecular interactions between extracellular components of the T-cell receptor signaling complex Immunological Reviews. 172: 73-85. PMID 10631938 DOI: 10.1111/J.1600-065X.1999.Tb01357.X |
0.444 |
|
| 1999 |
Garcia KC, Teyton L, Wilson IA. Structural basis of T cell recognition. Annual Review of Immunology. 17: 369-97. PMID 10358763 DOI: 10.1146/Annurev.Immunol.17.1.369 |
0.528 |
|
| 1998 |
Cai Z, Brunmark AB, Luxembourg AT, Garcia KC, Degano M, Teyton L, Wilson I, Peterson PA, Sprent J, Jackson MR. Probing the activation requirements for naive CD8+ T cells with Drosophila cell transfectants as antigen presenting cells Immunological Reviews. 165: 249-265. PMID 9850865 DOI: 10.1111/J.1600-065X.1998.Tb01243.X |
0.539 |
|
| 1998 |
Garcia KC, Teyton L. T-cell receptor peptide-MHC interactions: Biological lessons from structural studies Current Opinion in Biotechnology. 9: 338-343. PMID 9720260 DOI: 10.1016/S0958-1669(98)80004-9 |
0.442 |
|
| 1998 |
Speir JA, Garcia KC, Brunmark A, Degano M, Peterson PA, Teyton L, Wilson IA. Structural basis of 2C TCR allorecognition of H-2L(d) peptide complexes Immunity. 8: 553-562. PMID 9620676 DOI: 10.1016/S1074-7613(00)80560-9 |
0.463 |
|
| 1998 |
Manning TC, Schlueter CJ, Brodnicki TC, Parke EA, Speir JA, Garcia KC, Teyton L, Wilson IA, Kranz DM. Alanine scanning mutagenesis of an αβ T cell receptor: Mapping the energy of antigen recognition Immunity. 8: 413-425. PMID 9586632 DOI: 10.1016/S1074-7613(00)80547-6 |
0.516 |
|
| 1998 |
Garcia KC, Degano M, Pease LR, Huang M, Peterson PA, Teyton L, Wilson IA. Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen Science. 279: 1166-1172. PMID 9469799 DOI: 10.1126/Science.279.5354.1166 |
0.548 |
|
| 1998 |
Garcia K, Degano M, Teyton L, Wilson I. Structural basis of TCR-pMHC recognition Journal of Neuroimmunology. 90: 5. DOI: 10.1016/S0165-5728(98)91221-8 |
0.355 |
|
| 1997 |
Wilson IA, Garcia KC. T-cell receptor structure and TCR complexes. Current Opinion in Structural Biology. 7: 839-48. PMID 9434905 DOI: 10.1016/S0959-440X(97)80156-X |
0.556 |
|
| 1997 |
Garcia KC, Tallquist MD, Pease LR, Brunmark A, Scott CA, Degano M, Stura EA, Peterson PA, Wilson IA, Teyton L. αβ T cell receptor interactions with syngeneic and allogeneic ligands: Affinity measurements and crystallization Proceedings of the National Academy of Sciences of the United States of America. 94: 13838-13843. PMID 9391114 DOI: 10.1073/Pnas.94.25.13838 |
0.52 |
|
| 1997 |
Garcia KC, Scott CA, Brunmark A, Carbone FR, Peterson PA, Wilson IA, Teyton L. Erratum: CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes Nature. 387: 634-634. DOI: 10.1038/42529 |
0.506 |
|
| 1996 |
Garcia KC, Scott CA, Brunmark A, Carbone FR, Peterson PA, Wilson IA, Teyton L. CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes Nature. 384: 577-581. PMID 8955273 DOI: 10.1038/384577A0 |
0.514 |
|
| 1996 |
Garcia KC, Degano M, Stanfield RL, Brunmark A, Jackson MR, Peterson PA, Teyton L, Wilson IA. An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. Science (New York, N.Y.). 274: 209-19. PMID 8824178 DOI: 10.1126/Science.274.5285.209 |
0.537 |
|
| 1996 |
Scott CA, Garcia KC, Carbone FR, Wilson IA, Teyton L. Role of chain pairing for the production of functional soluble IA major histocompatibility complex class II molecules. The Journal of Experimental Medicine. 183: 2087-95. PMID 8642319 DOI: 10.1084/Jem.183.5.2087 |
0.423 |
|
| 1994 |
Amzel LM, Garcia KC, Desiderio S. Do antiidiotypic antibodies mimic antigen? Research in Immunology. 145: 53-55. PMID 7516565 DOI: 10.1016/S0923-2494(94)80044-8 |
0.437 |
|
| 1993 |
Murphy KP, Xie D, Garcia KC, Amzel LM, Freire E. Structural energetics of peptide recognition: Angiotensin II/antibody binding Proteins: Structure, Function and Genetics. 15: 113-120. PMID 8441749 DOI: 10.1002/Prot.340150203 |
0.597 |
|
| 1992 |
Garcia KC, Desiderio SV, Ronco PM, Verroust PJ, Amzel LM. Recognition of angiotensin II: antibodies at different levels of an idiotypic network are superimposable. Science (New York, N.Y.). 257: 528-31. PMID 1636087 |
0.476 |
|
| 1992 |
Garcia KC, Ronco PM, Verroust PJ, Brünger AT, Amzel LM. Three-dimensional structure of an angiotensin II-Fab complex at 3 A: hormone recognition by an anti-idiotypic antibody. Science (New York, N.Y.). 257: 502-7. PMID 1636085 DOI: 10.1126/Science.1636085 |
0.513 |
|
| 1989 |
Garcia KC, Ronco P, Verroust PJ, Amzel LM. Crystallization and preliminary X-ray diffraction data of an anti-angiotensin II Fab and of the peptide-Fab complex. The Journal of Biological Chemistry. 264: 20463-6. PMID 2584225 |
0.517 |
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