Knut Woltjen - Publications

Affiliations: 
CiRA, Kyoto University 
Area:
genome engineering, reprogramming, stem cells

41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Okubo T, Rivron N, Kabata M, Masaki H, Kishimoto K, Semi K, Nakajima-Koyama M, Kunitomi H, Kaswandy B, Sato H, Nakauchi H, Woltjen K, Saitou M, Sasaki E, Yamamoto T, et al. Publisher Correction: Hypoblast from human pluripotent stem cells regulates epiblast development. Nature. 626: E21. PMID 38347193 DOI: 10.1038/s41586-024-07166-w  0.385
2023 Okubo T, Rivron N, Kabata M, Masaki H, Kishimoto K, Semi K, Nakajima-Koyama M, Kunitomi H, Kaswandy B, Sato H, Nakauchi H, Woltjen K, Saitou M, Sasaki E, Yamamoto T, et al. Hypoblast from human pluripotent stem cells regulates epiblast development. Nature. PMID 38052228 DOI: 10.1038/s41586-023-06871-2  0.362
2023 Otomo J, Woltjen K, Sakurai H. Uniform transgene activation in Tet-On systems depends on sustained rtTA expression. Iscience. 26: 107685. PMID 37701566 DOI: 10.1016/j.isci.2023.107685  0.361
2023 Kubiura-Ichimaru M, Penfold C, Kojima K, Dollet C, Yabukami H, Semi K, Takashima Y, Boroviak T, Kawaji H, Woltjen K, Minoda A, Sasaki E, Watanabe T. mRNA-based generation of marmoset PGCLCs capable of differentiation into gonocyte-like cells. Stem Cell Reports. 18: 1987-2002. PMID 37683645 DOI: 10.1016/j.stemcr.2023.08.006  0.411
2022 Ueda T, Shiina S, Iriguchi S, Terakura S, Kawai Y, Kabai R, Sakamoto S, Watanabe A, Ohara K, Wang B, Xu H, Minagawa A, Hotta A, Woltjen K, Uemura Y, et al. Optimization of the proliferation and persistency of CAR T cells derived from human induced pluripotent stem cells. Nature Biomedical Engineering. 7: 24-37. PMID 36509913 DOI: 10.1038/s41551-022-00969-0  0.304
2021 Taguchi J, Shibata H, Kabata M, Kato M, Fukuda K, Tanaka A, Ohta S, Ukai T, Mitsunaga K, Yamada Y, Nagaoka SI, Yamazawa S, Ohnishi K, Woltjen K, Ushiku T, et al. DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency. Nature Communications. 12: 5041. PMID 34413299 DOI: 10.1038/s41467-021-25249-4  0.325
2021 Io S, Kabata M, Iemura Y, Semi K, Morone N, Minagawa A, Wang B, Okamoto I, Nakamura T, Kojima Y, Iwatani C, Tsuchiya H, Kaswandy B, Kondoh E, Kaneko S, ... Woltjen K, et al. Capturing human trophoblast development with naive pluripotent stem cells in vitro. Cell Stem Cell. PMID 33831365 DOI: 10.1016/j.stem.2021.03.013  0.312
2020 Maurissen TL, Woltjen K. Synergistic gene editing in human iPS cells via cell cycle and DNA repair modulation. Nature Communications. 11: 2876. PMID 32513994 DOI: 10.1038/s41467-020-16643-5  0.316
2020 Matsuda M, Yamanaka Y, Uemura M, Osawa M, Saito MK, Nagahashi A, Nishio M, Guo L, Ikegawa S, Sakurai S, Kihara S, Maurissen TL, Nakamura M, Matsumoto T, Yoshitomi H, ... ... Woltjen K, et al. Recapitulating the human segmentation clock with pluripotent stem cells. Nature. 580: 124-129. PMID 32238941 DOI: 10.1038/s41586-020-2144-9  0.382
2019 Sakakura M, Ohta S, Yagi M, Tanaka A, Norihide J, Woltjen K, Yamamoto T, Yamada Y. Smarcb1 maintains the cellular identity and the chromatin landscapes of mouse embryonic stem cells. Biochemical and Biophysical Research Communications. PMID 31543342 DOI: 10.1016/j.bbrc.2019.09.054  0.358
2019 Komura S, Ito K, Ohta S, Ukai T, Kabata M, Itakura F, Semi K, Matsuda Y, Hashimoto K, Shibata H, Sone M, Jo N, Sekiguchi K, Ohno T, Akiyama H, ... ... Woltjen K, et al. Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas. Nature Communications. 10: 3999. PMID 31488818 DOI: 10.1038/S41467-019-11745-1  0.349
2018 Kagawa H, Shimamoto R, Kim SI, Oceguera-Yanez F, Yamamoto T, Schroeder T, Woltjen K. OVOL1 Influences the Determination and Expansion of iPSC Reprogramming Intermediates. Stem Cell Reports. PMID 30639212 DOI: 10.1016/j.stemcr.2018.12.008  0.421
2018 Kim SI, Matsumoto T, Kagawa H, Nakamura M, Hirohata R, Ueno A, Ohishi M, Sakuma T, Soga T, Yamamoto T, Woltjen K. Microhomology-assisted scarless genome editing in human iPSCs. Nature Communications. 9: 939. PMID 29507284 DOI: 10.1038/s41467-018-03044-y  0.339
2017 Kojima Y, Sasaki K, Yokobayashi S, Sakai Y, Nakamura T, Yabuta Y, Nakaki F, Nagaoka S, Woltjen K, Hotta A, Yamamoto T, Saitou M. Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells. Cell Stem Cell. 21: 517-532.e5. PMID 28985527 DOI: 10.1016/J.Stem.2017.09.005  0.374
2017 Kieffer TJ, Woltjen K, Osafune K, Yabe D, Inagaki N. Beta-cell replacement strategies for diabetes. Journal of Diabetes Investigation. PMID 28984038 DOI: 10.1111/jdi.12758  0.318
2016 Komura S, Semi K, Itakura F, Shibata H, Ohno T, Hotta A, Woltjen K, Yamamoto T, Akiyama H, Yamada Y. An EWS-FLI1-Induced Osteosarcoma Model Unveiled a Crucial Role of Impaired Osteogenic Differentiation on Osteosarcoma Development. Stem Cell Reports. PMID 26997645 DOI: 10.1016/J.Stemcr.2016.02.009  0.319
2015 Oceguera-Yanez F, Kim SI, Matsumoto T, Tan GW, Long X, Hatani T, Kondo T, Ikeya M, Yoshida Y, Inoue H, Woltjen K. Engineering the AAVS1 locus for consistent and scalable transgene expression in human iPSCs and their differentiated derivatives. Methods (San Diego, Calif.). PMID 26707206 DOI: 10.1016/j.ymeth.2015.12.012  0.41
2015 Tamaki S, Fukuta M, Sekiguchi K, Jin Y, Nagata S, Hayakawa K, Hineno S, Okamoto T, Watanabe M, Woltjen K, Ikeya M, Kato T, Toguchida J. SS18-SSX, the Oncogenic Fusion Protein in Synovial Sarcoma, Is a Cellular Context-Dependent Epigenetic Modifier. Plos One. 10: e0142991. PMID 26571495 DOI: 10.1371/journal.pone.0142991  0.321
2015 Chantzoura E, Skylaki S, Menendez S, Kim SI, Johnsson A, Linnarsson S, Woltjen K, Chambers I, Kaji K. Reprogramming Roadblocks Are System Dependent. Stem Cell Reports. 5: 350-64. PMID 26278041 DOI: 10.1016/J.Stemcr.2015.07.007  0.306
2015 Sasaki K, Yokobayashi S, Nakamura T, Okamoto I, Yabuta Y, Kurimoto K, Ohta H, Moritoki Y, Iwatani C, Tsuchiya H, Nakamura S, Sekiguchi K, Sakuma T, Yamamoto T, Mori T, ... Woltjen K, et al. Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells. Cell Stem Cell. 17: 178-94. PMID 26189426 DOI: 10.1016/j.stem.2015.06.014  0.396
2015 Woltjen K, Kim SI, Nagy A. The piggyBac Transposon as a Platform Technology for Somatic Cell Reprogramming Studies in Mouse. Methods in Molecular Biology (Clifton, N.J.). PMID 26126450 DOI: 10.1007/7651_2015_274  0.55
2015 Kim SI, Oceguera-Yanez F, Sakurai C, Nakagawa M, Yamanaka S, Woltjen K. Inducible Transgene Expression in Human iPS Cells Using Versatile All-in-One piggyBac Transposons. Methods in Molecular Biology (Clifton, N.J.). PMID 26025620 DOI: 10.1007/7651_2015_251  0.463
2015 Shoji E, Woltjen K, Sakurai H. Directed Myogenic Differentiation of Human Induced Pluripotent Stem Cells. Methods in Molecular Biology (Clifton, N.J.). PMID 25971915 DOI: 10.1007/7651_2015_257  0.416
2014 Ohnishi K, Semi K, Yamamoto T, Shimizu M, Tanaka A, Mitsunaga K, Okita K, Osafune K, Arioka Y, Maeda T, Soejima H, Moriwaki H, Yamanaka S, Woltjen K, Yamada Y. Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation. Cell. 156: 663-77. PMID 24529372 DOI: 10.1016/j.cell.2014.01.005  0.301
2013 Yamashita A, Liu S, Woltjen K, Thomas B, Meng G, Hotta A, Takahashi K, Ellis J, Yamanaka S, Rancourt DE. Cartilage tissue engineering identifies abnormal human induced pluripotent stem cells. Scientific Reports. 3: 1978. PMID 23760219 DOI: 10.1038/srep01978  0.586
2013 Tanaka A, Woltjen K, Miyake K, Hotta A, Ikeya M, Yamamoto T, Nishino T, Shoji E, Sehara-Fujisawa A, Manabe Y, Fujii N, Hanaoka K, Era T, Yamashita S, Isobe K, et al. Efficient and reproducible myogenic differentiation from human iPS cells: prospects for modeling Miyoshi Myopathy in vitro. Plos One. 8: e61540. PMID 23626698 DOI: 10.1371/journal.pone.0061540  0.389
2013 Sakuma T, Hosoi S, Woltjen K, Suzuki K, Kashiwagi K, Wada H, Ochiai H, Miyamoto T, Kawai N, Sasakura Y, Matsuura S, Okada Y, Kawahara A, Hayashi S, Yamamoto T. Efficient TALEN construction and evaluation methods for human cell and animal applications. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 18: 315-26. PMID 23388034 DOI: 10.1111/gtc.12037  0.392
2013 Hayakawa K, Ikeya M, Fukuta M, Woltjen K, Tamaki S, Takahara N, Kato T, Sato S, Otsuka T, Toguchida J. Identification of target genes of synovial sarcoma-associated fusion oncoprotein using human pluripotent stem cells. Biochemical and Biophysical Research Communications. 432: 713-9. PMID 23313505 DOI: 10.1016/j.bbrc.2013.01.003  0.364
2012 Michael IP, Monetti C, Chiu AC, Zhang P, Baba T, Nishino K, Agha-Mohammadi S, Woltjen K, Sung HK, Nagy A. Highly efficient site-specific transgenesis in cancer cell lines. Molecular Cancer. 11: 89. PMID 23231822 DOI: 10.1186/1476-4598-11-89  0.454
2011 Gabut M, Samavarchi-Tehrani P, Wang X, Slobodeniuc V, O'Hanlon D, Sung HK, Alvarez M, Talukder S, Pan Q, Mazzoni EO, Nedelec S, Wichterle H, Woltjen K, Hughes TR, Zandstra PW, et al. An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell. 147: 132-46. PMID 21924763 DOI: 10.1016/J.Cell.2011.08.023  0.526
2011 Woltjen K, Hämäläinen R, Kibschull M, Mileikovsky M, Nagy A. Transgene-free production of pluripotent stem cells using piggyBac transposons. Methods in Molecular Biology (Clifton, N.J.). 767: 87-103. PMID 21822869 DOI: 10.1007/978-1-61779-201-4_7  0.599
2011 Nagy K, Sung HK, Zhang P, Laflamme S, Vincent P, Agha-Mohammadi S, Woltjen K, Monetti C, Michael IP, Smith LC, Nagy A. Induced pluripotent stem cell lines derived from equine fibroblasts. Stem Cell Reviews. 7: 693-702. PMID 21347602 DOI: 10.1007/S12015-011-9239-5  0.57
2011 Monetti C, Nishino K, Biechele S, Zhang P, Baba T, Woltjen K, Nagy A. PhiC31 integrase facilitates genetic approaches combining multiple recombinases. Methods (San Diego, Calif.). 53: 380-5. PMID 21185379 DOI: 10.1016/J.Ymeth.2010.12.023  0.527
2010 Samavarchi-Tehrani P, Golipour A, David L, Sung HK, Beyer TA, Datti A, Woltjen K, Nagy A, Wrana JL. Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell. 7: 64-77. PMID 20621051 DOI: 10.1016/J.Stem.2010.04.015  0.512
2010 O'Malley J, Woltjen K, Kaji K. New strategies to generate induced pluripotent stem cells. Current Opinion in Biotechnology. 20: 516-21. PMID 19837580 DOI: 10.1016/j.copbio.2009.09.005  0.434
2009 Woltjen K, Stanford WL. Preview. Inhibition of Tgf-beta signaling improves mouse fibroblast reprogramming. Cell Stem Cell. 5: 457-8. PMID 19896434 DOI: 10.1016/J.Stem.2009.10.007  0.351
2009 Woltjen K, Michael IP, Mohseni P, Desai R, Mileikovsky M, Hämäläinen R, Cowling R, Wang W, Liu P, Gertsenstein M, Kaji K, Sung HK, Nagy A. piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature. 458: 766-70. PMID 19252478 DOI: 10.1038/Nature07863  0.637
2009 Kaji K, Norrby K, Paca A, Mileikovsky M, Mohseni P, Woltjen K. Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature. 458: 771-5. PMID 19252477 DOI: 10.1038/nature07864  0.489
2008 Woltjen K, Ito K, Tsuzuki T, Rancourt DE. Orpheus recombination : a comprehensive bacteriophage system for murine targeting vector construction by transplacement. Methods in Molecular Biology (Clifton, N.J.). 435: 79-94. PMID 18370069 DOI: 10.1007/978-1-59745-232-8_6  0.533
2003 Thomas B, Woltjen K, Rancourt DE. Deep screening of recombination proficient bacteriophage libraries. Biotechniques. 34: 36-8, 40. PMID 12545535  0.469
2002 Woltjen K, Unger MW, Rancourt DE. Transplacement mutagenesis. A recombination-based in situ mutagenesis protocol. Methods in Molecular Biology (Clifton, N.J.). 182: 189-207. PMID 11768965  0.516
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