Jana Sawynok - Publications

Affiliations: 
Dalhousie University, Halifax, Nova Scotia, Canada 
Area:
pain, opioids

157 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Sawynok J. Adenosine receptor targets for pain. Neuroscience. PMID 26500181 DOI: 10.1016/j.neuroscience.2015.10.031  0.6
2015 Nascimento FP, Macedo-Júnior SJ, Pamplona FA, Luiz-Cerutti M, Córdova MM, Constantino L, Tasca CI, Dutra RC, Calixto JB, Reid A, Sawynok J, Santos AR. Adenosine A1 receptor-dependent antinociception induced by inosine in mice: pharmacological, genetic and biochemical aspects. Molecular Neurobiology. 51: 1368-78. PMID 25064055 DOI: 10.1007/S12035-014-8815-5  0.6
2014 Sawynok J, Lynch M. Qigong and fibromyalgia: randomized controlled trials and beyond. Evidence-Based Complementary and Alternative Medicine : Ecam. 2014: 379715. PMID 25477991 DOI: 10.1155/2014/379715  0.6
2014 Sawynok J. Topical analgesics for neuropathic pain in the elderly: current and future prospects. Drugs & Aging. 31: 853-62. PMID 25373920 DOI: 10.1007/s40266-014-0218-9  0.6
2014 Sawynok J, Lynch M. Qualitative analysis of a controlled trial of qigong for fibromyalgia: advancing understanding of an emerging health practice. Journal of Alternative and Complementary Medicine (New York, N.Y.). 20: 606-17. PMID 25072523 DOI: 10.1089/acm.2013.0348  0.6
2014 Sawynok J. Topical and peripheral ketamine as an analgesic. Anesthesia and Analgesia. 119: 170-8. PMID 24945127 DOI: 10.1213/ANE.0000000000000246  0.6
2014 Sawynok J, Liu J. Contributions of peripheral, spinal, and supraspinal actions to analgesia. European Journal of Pharmacology. 734: 114-21. PMID 24731877 DOI: 10.1016/j.ejphar.2014.04.006  0.6
2014 Sawynok J. Topical analgesics for neuropathic pain: preclinical exploration, clinical validation, future development. European Journal of Pain (London, England). 18: 465-81. PMID 24108446 DOI: 10.1002/j.1532-2149.2013.00400.x  0.6
2013 Sawynok J, Lynch M, Marcon D. Extension trial of qigong for fibromyalgia: a quantitative and qualitative study. Evidence-Based Complementary and Alternative Medicine : Ecam. 2013: 726062. PMID 24069054 DOI: 10.1155/2013/726062  0.6
2013 Sawynok J, Reid AR, Liu J. Spinal and peripheral adenosine A₁ receptors contribute to antinociception by tramadol in the formalin test in mice. European Journal of Pharmacology. 714: 373-8. PMID 23872384 DOI: 10.1016/j.ejphar.2013.07.012  0.6
2013 Liu J, Reid AR, Sawynok J. Antinociception by systemically-administered acetaminophen (paracetamol) involves spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors. Neuroscience Letters. 536: 64-8. PMID 23313594 DOI: 10.1016/j.neulet.2012.12.052  0.6
2013 Liu J, Reid AR, Sawynok J. Spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors, are involved in antinociception by systemically administered amitriptyline. European Journal of Pharmacology. 698: 213-9. PMID 23142373 DOI: 10.1016/j.ejphar.2012.10.042  0.6
2013 Sawynok J, Hiew C, Marcon D. Chaoyi Fanhuan Qigong and fibromyalgia: methodological issues and two case reports. Journal of Alternative and Complementary Medicine (New York, N.Y.). 19: 383-6. PMID 23140114 DOI: 10.1089/acm.2011.0861  0.6
2013 Sawynok J. Adenosine and pain Adenosine: a Key Link Between Metabolism and Brain Activity. 343-360. DOI: 10.1007/978-1-4614-3903-5_17  0.6
2012 Lynch M, Sawynok J, Hiew C, Marcon D. A randomized controlled trial of qigong for fibromyalgia. Arthritis Research & Therapy. 14: R178. PMID 22863206 DOI: 10.1186/ar3931  0.6
2012 Mankovsky T, Lynch M, Clark A, Sawynok J, Sullivan MJ. Pain catastrophizing predicts poor response to topical analgesics in patients with neuropathic pain. Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Sociã©Tã© Canadienne Pour Le Traitement De La Douleur. 17: 10-4. PMID 22518362  0.6
2012 Sawynok J, Reid AR. Caffeine inhibits antinociception by acetaminophen in the formalin test by inhibiting spinal adenosine A₁ receptors. European Journal of Pharmacology. 674: 248-54. PMID 22085758 DOI: 10.1016/j.ejphar.2011.10.036  0.6
2011 Watson CP, Gilron I, Sawynok J, Lynch ME. Nontricyclic antidepressant analgesics and pain: are serotonin norepinephrine reuptake inhibitors (SNRIs) any better? Pain. 152: 2206-10. PMID 21723037 DOI: 10.1016/j.pain.2011.05.032  0.6
2011 Sawynok J, Reid AR. Reduction of formalin-evoked responses and maintenance of peripheral antinociception by morphine against formalin in the spared nerve injury model. Neuroscience Letters. 494: 99-103. PMID 21371525 DOI: 10.1016/j.neulet.2011.02.067  0.6
2011 Sawynok J. Caffeine and pain. Pain. 152: 726-9. PMID 21041029 DOI: 10.1016/j.pain.2010.10.011  0.6
2011 Sawynok J. Methylxanthines and pain. Handbook of Experimental Pharmacology. 311-29. PMID 20859801 DOI: 10.1007/978-3-642-13443-2_11  0.6
2010 Watson CP, Gilron I, Sawynok J. A qualitative systematic review of head-to-head randomized controlled trials of oral analgesics in neuropathic pain. Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La SociéTé Canadienne Pour Le Traitement De La Douleur. 15: 147-57. PMID 20577657 DOI: 10.1155/2010/382781  0.6
2010 Sawynok J, Reid AR, Fredholm BB. Caffeine reverses antinociception by oxcarbazepine by inhibition of adenosine A1 receptors: insights using knockout mice. Neuroscience Letters. 473: 178-81. PMID 20176083 DOI: 10.1016/j.neulet.2010.02.028  0.6
2009 Lynch ME, Sawynok J, Bouchard A. A pilot trial of CFQ for treatment of fibromyalgia. Journal of Alternative and Complementary Medicine (New York, N.Y.). 15: 1057-8. PMID 19785530 DOI: 10.1089/acm.2009.0115  0.6
2009 Arsenault A, Sawynok J. Perisurgical amitriptyline produces a preventive effect on afferent hypersensitivity following spared nerve injury. Pain. 146: 308-14. PMID 19748184 DOI: 10.1016/j.pain.2009.08.003  0.6
2009 Sawynok J. Adenosine Receptors Peripheral Receptor Targets For Analgesia: Novel Approaches to Pain Management. 137-152. DOI: 10.1002/9780470522226.ch6  0.6
2008 Meisner JG, Reid AR, Sawynok J. Adrenergic regulation of P2X3 and TRPV1 receptors: differential effects of spared nerve injury. Neuroscience Letters. 444: 172-5. PMID 18722504 DOI: 10.1016/j.neulet.2008.08.032  0.6
2008 Sawynok J, Reid AR, Fredholm BB. Caffeine reverses antinociception by amitriptyline in wild type mice but not in those lacking adenosine A1 receptors. Neuroscience Letters. 440: 181-4. PMID 18562097 DOI: 10.1016/j.neulet.2008.05.074  0.6
2008 Sullivan MJL, Lynch ME, Clark AJ, Mankovsky T, Sawynok J. Catastrophizing and treatment outcome: Differential impact on response to placebo and active treatment outcome Contemporary Hypnosis. 25: 129-140. DOI: 10.1002/ch.365  0.6
2007 Meisner JG, Waldron JB, Sawynok J. Alpha1-adrenergic receptors augment P2X3 receptor-mediated nociceptive responses in the uninjured state. The Journal of Pain : Official Journal of the American Pain Society. 8: 556-62. PMID 17512257 DOI: 10.1016/j.jpain.2007.02.434  0.6
2007 Sawynok J. Adenosine and ATP receptors. Handbook of Experimental Pharmacology. 309-28. PMID 17087128 DOI: 10.1007/978-3-540-33823-9_11  0.6
2006 Sawynok J, Reid A, Meisner J. Pain behaviors produced by capsaicin: influence of inflammatory mediators and nerve injury. The Journal of Pain : Official Journal of the American Pain Society. 7: 134-41. PMID 16459279 DOI: 10.1016/j.jpain.2005.09.013  0.6
2005 Lynch ME, Clark AJ, Sawynok J, Sullivan MJ. Topical amitriptyline and ketamine in neuropathic pain syndromes: an open-label study. The Journal of Pain : Official Journal of the American Pain Society. 6: 644-9. PMID 16202956 DOI: 10.1016/j.jpain.2005.04.008  0.6
2005 Sawynok J. Topical analgesics in neuropathic pain. Current Pharmaceutical Design. 11: 2995-3004. PMID 16178758 DOI: 10.2174/1381612054865019  0.6
2005 Sawynok J, Reid AR, Liu XJ, Parkinson FE. Amitriptyline enhances extracellular tissue levels of adenosine in the rat hindpaw and inhibits adenosine uptake. European Journal of Pharmacology. 518: 116-22. PMID 16156010 DOI: 10.1016/j.ejphar.2005.06.030  0.6
2005 Lynch ME, Clark AJ, Sawynok J, Sullivan MJ. Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial. Anesthesiology. 103: 140-6. PMID 15983466 DOI: 10.1097/00000542-200507000-00021  0.6
2005 Sawynok J. Amitriptyline neurotoxicity. Anesthesiology. 102: 240-1; author reply . PMID 15618817  0.6
2004 Waldron JB, Reid AR, Sawynok J. Amitriptyline produces multiple influences on the peripheral enhancement of nociception by P2X receptors. European Journal of Pharmacology. 499: 275-83. PMID 15381049 DOI: 10.1016/j.ejphar.2004.07.116  0.6
2004 Waldron JB, Sawynok J. Peripheral P2X receptors and nociception: interactions with biogenic amine systems. Pain. 110: 79-89. PMID 15275755 DOI: 10.1016/j.pain.2004.03.012  0.6
2004 Aumeerally N, Allen G, Sawynok J. Glutamate-evoked release of adenosine and regulation of peripheral nociception. Neuroscience. 127: 1-11. PMID 15219663 DOI: 10.1016/j.neuroscience.2004.04.012  0.6
2004 Eisenach JC, Hood DD, Curry R, Sawynok J, Yaksh TL, Li X. Intrathecal but not intravenous opioids release adenosine from the spinal cord. The Journal of Pain : Official Journal of the American Pain Society. 5: 64-8. PMID 14975380 DOI: 10.1016/j.jpain.2003.10.001  0.6
2003 Lynch ME, Clark AJ, Sawynok J. A pilot study examining topical amitriptyline, ketamine, and a combination of both in the treatment of neuropathic pain. The Clinical Journal of Pain. 19: 323-8. PMID 12966259 DOI: 10.1097/00002508-200309000-00007  0.6
2003 Oatway M, Reid A, Sawynok J. Peripheral antihyperalgesic and analgesic actions of ketamine and amitriptyline in a model of mild thermal injury in the rat. Anesthesia and Analgesia. 97: 168-73, table of con. PMID 12818961 DOI: 10.1213/01.Ane.0000067406.52093.Bf  0.6
2003 Sawynok J, Liu XJ. Adenosine in the spinal cord and periphery: release and regulation of pain. Progress in Neurobiology. 69: 313-40. PMID 12787573 DOI: 10.1016/S0301-0082(03)00050-9  0.6
2003 Lynch ME, Clark AJ, Sawynok J. Intravenous adenosine alleviates neuropathic pain: a double blind placebo controlled crossover trial using an enriched enrolment design. Pain. 103: 111-7. PMID 12749965 DOI: 10.1016/S0304-3959(02)00419-0  0.6
2003 Sawynok J, Reid A. Chronic intrathecal cannulas inhibit some and potentiate other behaviors elicited by formalin injection. Pain. 103: 7-9. PMID 12749953 DOI: 10.1016/S0304-3959(02)00061-1  0.6
2003 Sawynok J, Reid A. Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats. Pain. 102: 179-86. PMID 12620609 DOI: 10.1016/s0304-3959(02)00373-1  0.6
2003 Sawynok J. Topical and peripherally acting analgesics. Pharmacological Reviews. 55: 1-20. PMID 12615951 DOI: 10.1124/pr.55.1.1  0.6
2003 Sawynok J. Recent findings surrounding topical antidepressants as analgesics and review of existing and emerging topical analgesics Advanced Studies in Medicine. 3: S635-S641.  0.6
2002 Sawynok J, Reid A. Modulation of formalin-induced behaviors and edema by local and systemic administration of dextromethorphan, memantine and ketamine. European Journal of Pharmacology. 450: 153-62. PMID 12206853 DOI: 10.1016/S0014-2999(02)02119-2  0.6
2002 Liu XJ, White TD, Sawynok J. Enhanced release of adenosine in rat hind paw following spinal nerve ligation: involvement of capsaicin-sensitive sensory afferents. Neuroscience. 114: 379-87. PMID 12204207 DOI: 10.1016/S0306-4522(02)00295-6  0.6
2002 Heughan CE, Sawynok J. The interaction between gabapentin and amitriptyline in the rat formalin test after systemic administration. Anesthesia and Analgesia. 94: 975-80, table of con. PMID 11916807 DOI: 10.1097/00000539-200204000-00037  0.6
2002 Liu XJ, White TD, Sawynok J. Intraplantar injection of glutamate evokes peripheral adenosine release in the rat hind paw: involvement of peripheral ionotropic glutamate receptors and capsaicin-sensitive sensory afferents. Journal of Neurochemistry. 80: 562-70. PMID 11841563 DOI: 10.1046/j.0022-3042.2001.00721.x  0.6
2002 Heughan CE, Allen GV, Chase TD, Sawynok J. Peripheral amitriptyline suppresses formalin-induced Fos expression in the rat spinal cord. Anesthesia and Analgesia. 94: 427-31, table of con. PMID 11812713 DOI: 10.1213/00000539-200202000-00038  0.6
2001 Esser MJ, Chase T, Allen GV, Sawynok J. Chronic administration of amitriptyline and caffeine in a rat model of neuropathic pain: multiple interactions. European Journal of Pharmacology. 430: 211-8. PMID 11711033 DOI: 10.1016/S0014-2999(01)01276-6  0.6
2001 Liu XJ, White TD, Sawynok J. Involvement of primary sensory afferents, postganglionic sympathetic nerves and mast cells in the formalin-evoked peripheral release of adenosine. European Journal of Pharmacology. 429: 147-55. PMID 11698037 DOI: 10.1016/S0014-2999(01)01316-4  0.6
2001 Sawynok J, Reid A. Antinociception by tricyclic antidepressants in the rat formalin test: differential effects on different behaviours following systemic and spinal administration. Pain. 93: 51-9. PMID 11406338 DOI: 10.1016/S0304-3959(01)00291-3  0.6
2001 Sawynok J, Esser MJ, Reid AR. Antidepressants as analgesics: an overview of central and peripheral mechanisms of action. Journal of Psychiatry & Neuroscience : Jpn. 26: 21-9. PMID 11212590  0.6
2001 Sawynok J. Antidepressants as analgesics: an introduction. Journal of Psychiatry & Neuroscience : Jpn. 26: 20. PMID 11212589  0.6
2000 Liu XJ, White TD, Sawynok J. Potentiation of formalin-evoked adenosine release by an adenosine kinase inhibitor and an adenosine deaminase inhibitor in the rat hind paw: a microdialysis study. European Journal of Pharmacology. 408: 143-52. PMID 11080520 DOI: 10.1016/S0014-2999(00)00742-1  0.6
2000 Esser MJ, Sawynok J. Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain. European Journal of Pharmacology. 399: 131-9. PMID 10884512 DOI: 10.1016/S0014-2999(00)00336-8  0.6
2000 Sawynok J, Reid A, Liu XJ. Involvement of mast cells, sensory afferents and sympathetic mechanisms in paw oedema induced by adenosine A(1) and A(2B/3) receptor agonists. European Journal of Pharmacology. 395: 47-50. PMID 10781673 DOI: 10.1016/S0014-2999(00)00125-4  0.6
2000 McCleane G, Sawynok J, Esser MJ. Peripheral antinociceptive actions of desimipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat: Comments on J. Sawynok, M.J. Esser, A.R. Reid, PAIN, 82 (1999) 149-158 (multiple letters) Pain. 85: 311. PMID 10766601  0.6
1999 Sawynok J, Reid A, Liu XJ. Acute paw oedema induced by local injection of adenosine A(1), A(2) and A(3) receptor agonists. European Journal of Pharmacology. 386: 253-61. PMID 10618477 DOI: 10.1016/S0014-2999(99)00752-9  0.6
1999 Poon A, Sawynok J. Antinociceptive and anti-inflammatory properties of an adenosine kinase inhibitor and an adenosine deaminase inhibitor. European Journal of Pharmacology. 384: 123-38. PMID 10611432 DOI: 10.1016/S0014-2999(99)00626-3  0.6
1999 Sawynok J, Esser MJ, Reid AR. Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat. Pain. 82: 149-58. PMID 10467920 DOI: 10.1016/S0304-3959(99)00043-3  0.6
1999 Esser MJ, Sawynok J. Acute amitriptyline in a rat model of neuropathic pain: differential symptom and route effects. Pain. 80: 643-53. PMID 10342426 DOI: 10.1016/S0304-3959(98)00261-9  0.6
1999 Sawynok J, Reid AR, Esser MJ. Peripheral antinociceptive action of amitriptyline in the rat formalin test: involvement of adenosine. Pain. 80: 45-55. PMID 10204717 DOI: 10.1016/S0304-3959(98)00195-X  0.6
1998 Sawynok J. Adenosine receptor activation and nociception. European Journal of Pharmacology. 347: 1-11. PMID 9650842 DOI: 10.1016/S0014-2999(97)01605-1  0.6
1998 Poon A, Sawynok J. Antinociception by adenosine analogs and inhibitors of adenosine metabolism in an inflammatory thermal hyperalgesia model in the rat. Pain. 74: 235-45. PMID 9520238 DOI: 10.1016/S0304-3959(97)00186-3  0.6
1998 Sawynok J, Reid A, Poon A. Peripheral antinociceptive effect of an adenosine kinase inhibitor, with augmentation by an adenosine deaminase inhibitor, in the rat formalin test. Pain. 74: 75-81. PMID 9514563 DOI: 10.1016/S0304-3959(97)00153-X  0.6
1998 Sawynok J, Doak G, Poon A. Adenosine and pain: Recent findings with directly and indirectly acting agents Drug Development Research. 45: 304-311. DOI: 10.1002/(Sici)1098-2299(199811/12)45:3/4<304::Aid-Ddr29>3.0.Co;2-L  0.6
1997 Sawynok J, Zarrindast MR, Reid AR, Doak GJ. Adenosine A3 receptor activation produces nociceptive behaviour and edema by release of histamine and 5-hydroxytryptamine. European Journal of Pharmacology. 333: 1-7. PMID 9311654 DOI: 10.1016/S0014-2999(97)01110-2  0.6
1997 Doak GJ, Sawynok J. Formalin-induced nociceptive behavior and edema: involvement of multiple peripheral 5-hydroxytryptamine receptor subtypes. Neuroscience. 80: 939-49. PMID 9276504 DOI: 10.1016/S0306-4522(97)00066-3  0.6
1997 Sawynok J, Reid A. Peripheral adenosine 5'-triphosphate enhances nociception in the formalin test via activation of a purinergic p2X receptor. European Journal of Pharmacology. 330: 115-21. PMID 9253943 DOI: 10.1016/S0014-2999(97)01001-7  0.6
1997 Cahill CM, White TD, Sawynok J. Substance P releases and augments the morphine-evoked release of adenosine from spinal cord. Brain Research. 760: 294-7. PMID 9237551 DOI: 10.1016/S0006-8993(97)00473-3  0.6
1996 Cahill CM, White TD, Sawynok J. Synergy between mu/delta-opioid receptors mediates adenosine release from spinal cord synaptosomes. European Journal of Pharmacology. 298: 45-9. PMID 8867918 DOI: 10.1016/0014-2999(95)00775-X  0.6
1996 Sawynok J, Reid A. Caffeine antinociception: role of formalin concentration and adenosine A1 and A2 receptors. European Journal of Pharmacology. 298: 105-11. PMID 8867096 DOI: 10.1016/0014-2999(95)00791-1  0.6
1996 Golembiowska K, White TD, Sawynok J. Adenosine kinase inhibitors augment release of adenosine from spinal cord slices. European Journal of Pharmacology. 307: 157-62. PMID 8832217 DOI: 10.1016/0014-2999(96)00248-8  0.6
1996 Sawynok J, Reid A. Interactions of descending serotonergic systems with other neurotransmitters in the modulation of nociception. Behavioural Brain Research. 73: 63-8. PMID 8788479 DOI: 10.1016/0166-4328(96)00072-1  0.6
1996 Sawynok J, Reid A. Neurotoxin-induced lesions to central serotonergic, noradrenergic and dopaminergic systems modify caffeine-induced antinociception in the formalin test and locomotor stimulation in rats. The Journal of Pharmacology and Experimental Therapeutics. 277: 646-53. PMID 8627541  0.6
1996 Sawynok J. Caffeine: Biochemistry, pharmacology, and adjuvant effects International Congress and Symposium Series - Royal Society of Medicine. 35-42.  0.6
1995 Golembiowska K, White TD, Sawynok J. Modulation of adenosine release from rat spinal cord by adenosine deaminase and adenosine kinase inhibitors. Brain Research. 699: 315-20. PMID 8616636 DOI: 10.1016/0006-8993(95)00926-H  0.6
1995 Poon A, Sawynok J. Antinociception by adenosine analogs and an adenosine kinase inhibitor: dependence on formalin concentration. European Journal of Pharmacology. 286: 177-84. PMID 8605954 DOI: 10.1016/0014-2999(95)00444-P  0.6
1995 Doak GJ, Sawynok J. Complex role of peripheral adenosine in the genesis of the response to subcutaneous formalin in the rat. European Journal of Pharmacology. 281: 311-8. PMID 8521915 DOI: 10.1016/0014-2999(95)00257-L  0.6
1995 Sawynok J. Pharmacological rationale for the clinical use of caffeine. Drugs. 49: 37-50. PMID 7705215 DOI: 10.2165/00003495-199549010-00004  0.6
1995 Sawynok J, Reid AR, Doak GJ. Caffeine antinociception in the rat hot-plate and formalin tests and locomotor stimulation: involvement of noradrenergic mechanisms. Pain. 61: 203-13. PMID 7659430 DOI: 10.1016/0304-3959(94)00169-F  0.6
1995 Cahill CM, White TD, Sawynok J. Spinal opioid receptors and adenosine release: neurochemical and behavioral characterization of opioid subtypes. The Journal of Pharmacology and Experimental Therapeutics. 275: 84-93. PMID 7562600  0.6
1994 Sawynok J, Reid A. Spinal supersensitivity to 5-HT1, 5-HT2 and 5-HT3 receptor agonists following 5,7-dihydroxytryptamine. European Journal of Pharmacology. 264: 249-57. PMID 7698162 DOI: 10.1016/0014-2999(94)00465-X  0.6
1993 Sawynok J, Downie JW, Reid AR, Cahill CM, White TD. ATP release from dorsal spinal cord synaptosomes: characterization and neuronal origin. Brain Research. 610: 32-8. PMID 8518929 DOI: 10.1016/0006-8993(93)91213-C  0.6
1993 Sawynok J, Yaksh TL. Caffeine as an analgesic adjuvant: a review of pharmacology and mechanisms of action. Pharmacological Reviews. 45: 43-85. PMID 8475169  0.6
1993 Sweeney MI, White TD, Sawynok J. Morphine-evoked release of adenosine from the spinal cord occurs via a nucleoside carrier with differential sensitivity to dipyridamole and nitrobenzylthioinosine. Brain Research. 614: 301-7. PMID 8348322 DOI: 10.1016/0006-8993(93)90444-R  0.6
1993 Cahill CM, White TD, Sawynok J. Influence of calcium on the release of endogenous adenosine from spinal cord synaptosomes. Life Sciences. 53: 487-96. PMID 8341135 DOI: 10.1016/0024-3205(93)90700-D  0.6
1993 Cahill CM, White TD, Sawynok J. Morphine activates omega-conotoxin-sensitive Ca2+ channels to release adenosine from spinal cord synaptosomes. Journal of Neurochemistry. 60: 894-901. PMID 7679729 DOI: 10.1111/j.1471-4159.1993.tb03234.x  0.6
1993 Cahill CM, White TD, Sawynok J. Involvement of calcium channels in depolarization-evoked release of adenosine from spinal cord synaptosomes. Journal of Neurochemistry. 60: 886-93. PMID 7679728 DOI: 10.1111/J.1471-4159.1993.Tb03233.X  0.6
1993 Sawynok J, Reid A. Evaluation of 5-HT1 receptor subtypes interacting with spinal noradrenergic systems in two tests for nociception Regional Anesthesia. 18: 34.  0.6
1992 Sawynok J, Reid A. Desipramine potentiates spinal antinociception by 5-hydroxytryptamine, morphine and adenosine. Pain. 50: 113-8. PMID 1513600 DOI: 10.1016/0304-3959(92)90118-U  0.6
1992 Sawynok J, Reid A. Noradrenergic mediation of spinal antinociception by 5-hydroxytryptamine: characterization of receptor subtypes. European Journal of Pharmacology. 223: 49-56. PMID 1362158 DOI: 10.1016/0014-2999(92)90817-N  0.6
1991 Sawynok J, Reid A, Nance D. Spinal antinociception by adenosine analogs and morphine after intrathecal administration of the neurotoxins capsaicin, 6-hydroxydopamine and 5,7-dihydroxytryptamine. The Journal of Pharmacology and Experimental Therapeutics. 258: 370-80. PMID 1906540  0.6
1991 Sawynok J, Espey MJ, Reid A. 8-Phenyltheophylline reverses the antinociceptive action of morphine in the periaqueductal gray. Neuropharmacology. 30: 871-7. PMID 1780044 DOI: 10.1016/0028-3908(91)90121-Q  0.6
1991 Nicholson D, White TD, Sawynok J. Forskolin and phosphodiesterase inhibitors release adenosine but inhibit morphine-evoked release of adenosine from spinal cord synaptosomes. Canadian Journal of Physiology and Pharmacology. 69: 877-85. PMID 1717120 DOI: 10.1139/Y91-133  0.6
1991 Nicholson D, Reid A, Sawynok J. Effects of forskolin and phosphodiesterase inhibitors on spinal antinociception by morphine. Pharmacology, Biochemistry, and Behavior. 38: 753-8. PMID 1714608 DOI: 10.1016/0091-3057(91)90237-V  0.6
1991 Sawynok J, Reid A. Noradrenergic and purinergic involvement in spinal antinociception by 5-hydroxytryptamine and 2-methyl-5-hydroxytryptamine. European Journal of Pharmacology. 204: 301-9. PMID 1663459 DOI: 10.1016/0014-2999(91)90856-L  0.6
1991 Sweeney MI, White TD, Sawynok J. Intracerebroventricular morphine releases adenosine and adenosine 3',5'-cyclic monophosphate from the spinal cord via a serotonergic mechanism. The Journal of Pharmacology and Experimental Therapeutics. 259: 1013-8. PMID 1662270  0.6
1990 Sawynok J, Reid A. Supersensitivity to intrathecal 5-hydroxytryptamine, but not noradrenaline, following depletion of spinal 5-hydroxytryptamine by 5,7-dihydroxytryptamine administered into various sites. Naunyn-Schmiedeberg's Archives of Pharmacology. 342: 1-8. PMID 2402297 DOI: 10.1007/BF00178964  0.6
1990 Sawynok J, Sweeney M, Nicholson D, White T. Pertussis toxin inhibits morphine-induced release of adenosine from the spinal cord. Progress in Clinical and Biological Research. 328: 397-400. PMID 2304959  0.6
1990 Sweeney MI, White TD, Sawynok J. 5-Hydroxytryptamine releases adenosine and cyclic AMP from primary afferent nerve terminals in the spinal cord in vivo. Brain Research. 528: 55-61. PMID 2173965 DOI: 10.1016/0006-8993(90)90194-G  0.6
1990 Sawynok J, Reid A, Isbrucker R. Adenosine mediates calcium-induced antinociception and potentiation of noradrenergic antinociception in the spinal cord. Brain Research. 524: 187-95. PMID 2127235 DOI: 10.1016/0006-8993(90)90689-9  0.6
1990 Sawynok J, Nicholson DJ, Sweeney MI, White TD. Adenosine release by morphine and spinal antinociception: role of G-proteins and cyclic AMP. Nida Research Monograph. 105: 40-6. PMID 1652084  0.6
1990 Sweeney MI, White TD, Sawynok J. Intracerebroventricular morphine releases cyclic AMP and adenosine from the spinal cord via a serotonergic mechanism European Journal of Pharmacology. 183: 1450-1451. DOI: 10.1016/0014-2999(90)94589-P  0.6
1989 Sawynok J, Sweeney MI. The role of purines in nociception. Neuroscience. 32: 557-69. PMID 2689906 DOI: 10.1016/0306-4522(89)90278-9  0.6
1989 Sawynok J. The 1988 Merck Frosst Award. The role of ascending and descending noradrenergic and serotonergic pathways in opioid and non-opioid antinociception as revealed by lesion studies. Canadian Journal of Physiology and Pharmacology. 67: 975-88. PMID 2688867 DOI: 10.1139/Y89-154  0.6
1989 Sawynok J, Sweeney MI, White TD. Adenosine release may mediate spinal analgesia by morphine. Trends in Pharmacological Sciences. 10: 186-9. PMID 2667227 DOI: 10.1016/0165-6147(89)90235-6  0.6
1989 Sawynok J, Reid A. Lesions to ascending noradrenergic and serotonergic pathways modify antinociception produced by intracerebroventricular administration of morphine. Neuropharmacology. 28: 141-7. PMID 2497401 DOI: 10.1016/0028-3908(89)90050-6  0.6
1989 Sweeney MI, White TD, Sawynok J. Morphine, capsaicin and K+ release purines from capsaicin-sensitive primary afferent nerve terminals in the spinal cord. The Journal of Pharmacology and Experimental Therapeutics. 248: 447-54. PMID 2492344  0.6
1988 Sawynok J, Reid A. Role of ascending and descending serotonergic pathways in the antinociceptive effect of baclofen. Naunyn-Schmiedeberg's Archives of Pharmacology. 337: 359-65. PMID 3405312 DOI: 10.1007/BF00169524  0.6
1988 Hoehn K, Reid A, Sawynok J. Pertussis toxin inhibits antinociception produced by intrathecal injection of morphine, noradrenaline and baclofen. European Journal of Pharmacology. 146: 65-72. PMID 3350059 DOI: 10.1016/0014-2999(88)90487-6  0.6
1988 Sweeney M, White T, Sawynok J. 5-Hydroxytryptamine releases adenosine from primary afferent nerve terminals in the spinal cord. Brain Research. 462: 346-9. PMID 3191394 DOI: 10.1016/0006-8993(88)90562-8  0.6
1988 Sawynok J, Reid A. Role of G-proteins and adenylate cyclase in antinociception produced by intrathecal purines. European Journal of Pharmacology. 156: 25-34. PMID 3145208 DOI: 10.1016/0014-2999(88)90143-4  0.6
1987 Sweeney MI, White TD, Jhamandas KH, Sawynok J. Morphine releases endogenous adenosine from the spinal cord in vivo. European Journal of Pharmacology. 141: 169-70. PMID 3666024 DOI: 10.1016/0014-2999(87)90428-6  0.6
1987 Duan J, Sawynok J. Enhancement of clonidine-induced analgesia by lesions induced with spinal and intracerebroventricular administration of 5,7-dihydroxytryptamine. Neuropharmacology. 26: 323-9. PMID 3587536 DOI: 10.1016/0028-3908(87)90184-5  0.6
1987 Sawynok J, Reid A. Effect of 6-hydroxydopamine-induced lesions to ascending and descending noradrenergic pathways on morphine analgesia. Brain Research. 419: 156-65. PMID 3119144 DOI: 10.1016/0006-8993(87)90579-8  0.6
1987 Sawynok J. GABAergic mechanisms of analgesia: an update. Pharmacology, Biochemistry, and Behavior. 26: 463-74. PMID 3033701 DOI: 10.1016/0091-3057(87)90148-1  0.6
1987 Sweeney MI, White TD, Sawynok J. Involvement of adenosine in the spinal antinociceptive effects of morphine and noradrenaline. The Journal of Pharmacology and Experimental Therapeutics. 243: 657-65. PMID 2824755  0.6
1987 Nance PW, Sawynok J. Substance P-induced long-term blockade of spinal adrenergic analgesia: reversal by morphine and naloxone. The Journal of Pharmacology and Experimental Therapeutics. 240: 972-7. PMID 2435888  0.6
1986 Sawynok J, Reid A. Role of ascending and descending noradrenergic pathways in the antinociceptive effect of baclofen and clonidine. Brain Research. 386: 341-50. PMID 3096496 DOI: 10.1016/0006-8993(86)90171-X  0.6
1986 Sawynok J. Baclofen activates two distinct receptors in the rat spinal cord and guinea pig ileum. Neuropharmacology. 25: 795-8. PMID 3018622 DOI: 10.1016/0028-3908(86)90098-5  0.6
1986 Sawynok J, Sweeney MI, White TD. Classification of adenosine receptors mediating antinociception in the rat spinal cord. British Journal of Pharmacology. 88: 923-30. PMID 3017496 DOI: 10.1111/J.1476-5381.1986.Tb16267.X  0.6
1986 Sawynok J, Reid A. Clonidine reverses baclofen-induced increases in noradrenaline turnover in rat brain. Neurochemical Research. 11: 723-31. PMID 2873522 DOI: 10.1007/BF00965340  0.6
1986 Sweeney MI, Sawynok J. Evidence that substance P may be a modulator rather than a transmitter of noxious mechanical stimulation. Canadian Journal of Physiology and Pharmacology. 64: 1324-7. PMID 2433009  0.6
1986 Sawynok J. The therapeutic use of heroin: a review of the pharmacological literature. Canadian Journal of Physiology and Pharmacology. 64: 1-6. PMID 2420426 DOI: 10.1139/Y86-001  0.6
1985 Sawynok J, Dickson C. Evidence for the involvement of descending noradrenergic pathways in the antinociceptive effect of baclofen. Brain Research. 335: 89-97. PMID 3924340 DOI: 10.1016/0006-8993(85)90279-3  0.6
1985 Sawynok J, Dickson C. D-Baclofen is an antagonist at baclofen receptors mediating antinociception in the spinal cord. Pharmacology. 31: 248-59. PMID 2999839  0.6
1985 Sawynok J, Robertson G. Desensitization to substance P following intrathecal injection. A technique for investigating the role of substance P in nociception. Naunyn-Schmiedeberg's Archives of Pharmacology. 331: 152-8. PMID 2418368 DOI: 10.1007/Bf00634232  0.6
1985 Steardo L, Sawynok J. Clonidine reverses methylxanthine-induced potentiation of baclofen antinociception. Pharmacology, Biochemistry, and Behavior. 22: 905-7. PMID 2409562 DOI: 10.1016/0091-3057(85)90546-5  0.6
1984 Sawynok J, Moochhala SM, Pillay DJ. Substance P, injected intrathecally, antagonizes the spinal antinociceptive effect of morphine, baclofen and noradrenaline. Neuropharmacology. 23: 741-7. PMID 6206433 DOI: 10.1016/0028-3908(84)90106-0  0.6
1984 Moochhala SM, Sawynok J. Hyperalgesia produced by intrathecal substance P and related peptides: desensitization and cross desensitization. British Journal of Pharmacology. 82: 381-8. PMID 6203593 DOI: 10.1111/J.1476-5381.1984.Tb10773.X  0.6
1984 Sawynok J, Dickson C. D-Baclofen: is it an antagonist at baclofen receptors? Progress in Neuro-Psychopharmacology & Biological Psychiatry. 8: 729-31. PMID 6099593 DOI: 10.1016/0278-5846(84)90047-2  0.6
1984 Sawynok J. GABAergic mechanisms in antinociception. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 8: 581-6. PMID 6085175 DOI: 10.1016/0278-5846(84)90018-6  0.6
1983 Sawynok J. Monoamines as mediators of the antinociceptive effect of baclofen. Naunyn-Schmiedeberg's Archives of Pharmacology. 323: 54-7. PMID 6877393 DOI: 10.1007/BF00498828  0.6
1983 Sawynok J. Theophylline-induced potentiation of the antinociceptive action of baclofen. British Journal of Pharmacology. 78: 353-7. PMID 6831116  0.6
1983 Sawynok J, Dickson C. Involvement of GABA in the antinociceptive effect of gamma-acetylenic GABA (GAG), an inhibitor of GABA-transaminase. General Pharmacology. 14: 603-7. PMID 6662342 DOI: 10.1016/0306-3623(83)90156-8  0.6
1982 Sawynok J, LaBella FS. On the involvement of GABA in the analgesia produced by baclofen, muscimol and morphine. Neuropharmacology. 21: 397-403. PMID 7110528 DOI: 10.1016/0028-3908(82)90022-3  0.6
1982 Sawynok J, Kato N, Havlicek V, LaBella FS. Lack of effect of baclofen on substance P and somatostatin release from the spinal cord in vitro. Naunyn-Schmiedeberg's Archives of Pharmacology. 319: 78-81. PMID 6180329 DOI: 10.1007/BF00491482  0.6
1981 Sawynok J, Labella FS. GABA and baclofen potentiate the K+-evoked release of methionine-enkephalin from rat striatal slices. European Journal of Pharmacology. 70: 103-10. PMID 6266839 DOI: 10.1016/0014-2999(81)90204-1  0.6
1981 Sawynok J, Labella FS. Naloxone antagonizes inhibitory and unmasks excitatory effects of baclofen. The Journal of Pharmacy and Pharmacology. 33: 597-9. PMID 6117640  0.6
1980 Sawynok J, Labella FS, Pinsky C. Effects of morphine and naloxone on the K+-stimulated release of methionine-enkephalin from slices of rat corpus striatum. Brain Research. 189: 483-93. PMID 7370786 DOI: 10.1016/0006-8993(80)90107-9  0.6
1980 Panerai AE, Sawynok J, LaBella FS, Friesen HG. Prolonged hyperprolactinemia influences beta-endorphin and Met-enkephalin in the brain. Endocrinology. 106: 1804-8. PMID 6245852 DOI: 10.1210/endo-106-6-1804  0.6
1979 Sawynok J, Jhamandas K. Interactions of methylxanthines, nonxanthine phosphodiesterase inhibitors, and calcium with morphine in the guinea pig myenteric plexus. Canadian Journal of Physiology and Pharmacology. 57: 853-9. PMID 497898 DOI: 10.1139/Y79-130  0.6
1979 Sawynok J, Pinsky C, LaBella FS. On the specificity of naloxone as an opiate antagonist. Life Sciences. 25: 1621-32. PMID 229377 DOI: 10.1016/0024-3205(79)90403-X  0.6
1978 Jhamandas K, Sawynok J, Sutak M. Antagonism of morphine action on brain acetylcholine release by methylxanthines and calcium. European Journal of Pharmacology. 49: 309-12. PMID 658146 DOI: 10.1016/0014-2999(78)90108-5  0.6
1977 Jhamandas K, Sawynok J, Sutak M. Enkephalin effects on release of brain acetylcholine. Nature. 269: 433-4. PMID 909592  0.6
1977 Sawynok J, Jhamandas K. Muscarinic feedback inhibition of acetylcholine release from the myenteric plexus in the quinea pig ileum and its status after chronic exposure to morphine. Canadian Journal of Physiology and Pharmacology. 55: 909-16. PMID 902164 DOI: 10.1139/Y77-121  0.6
1977 Jhamandas K, Sawynok J, Sutak M. Action of opiate peptides on the release of brain acetylcholine Pharmacologist. 19: No. 356.  0.6
1976 Sawynok J, Jhamandas KH. Inhibition of acetylcholine release from cholinergic nerves by adenosine, adenine nucleotides and morphine: antagonism by theophylline. The Journal of Pharmacology and Experimental Therapeutics. 197: 379-90. PMID 1271286  0.6
1975 Sawynok J, Dawborn JK. Plasma concentration and urinary excretion of guanidine derivatives in normal subjects and patients with renal failure. Clinical and Experimental Pharmacology & Physiology. 2: 1-15. PMID 1126056  0.6
1973 Fennessy MR, Sawynok J. The effect of benzodiazepines on the analgesic effect of morphine and sodium salicylate. Archives Internationales De Pharmacodynamie Et De Thã©Rapie. 204: 77-85. PMID 4746633  0.6
Show low-probability matches.