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Raymond E. Moellering, Ph.D. - Publications

Affiliations: 
Chemistry University of Chicago, Chicago, IL 
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33 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Stein BD, Ferrarone JR, Gardner EE, Chang JW, Wu D, Hollstein PE, Liang RJ, Yuan M, Chen Q, Coukos JS, Sindelar M, Ngo B, Gross SS, Shaw RJ, Zhang C, ... ... Moellering RE, et al. LKB1-dependent regulation of TPI1 creates a divergent metabolic liability between human and mouse lung adenocarcinoma. Cancer Discovery. PMID 36715544 DOI: 10.1158/2159-8290.CD-22-0805  0.44
2022 Coukos JS, Lee CW, Pillai KS, Liu KJ, Moellering RE. Widespread, Reversible Cysteine Modification by Methylglyoxal Regulates Metabolic Enzyme Function. Acs Chemical Biology. PMID 36562291 DOI: 10.1021/acschembio.2c00727  0.319
2021 Coukos JS, Moellering RE. Methylglyoxal Forms Diverse Mercaptomethylimidazole Crosslinks with Thiol and Guanidine Pairs in Endogenous Metabolites and Proteins. Acs Chemical Biology. 16: 2453-2461. PMID 34581579 DOI: 10.1021/acschembio.1c00553  0.336
2020 Chang J, Bhuiyan M, Tsai HM, Zhang H, Li G, Fathi S, McCutcheon D, Leoni L, Freifelder R, Chen CT, Moellering R. In vivo imaging of the tumor-associated enzyme NCEH1 with a covalent PET probe. Angewandte Chemie (International Ed. in English). PMID 32415874 DOI: 10.1002/Anie.202004762  0.524
2020 Huang JX, Coukos JS, Moellering RE. Interaction profiling methods to map protein and pathway targets of bioactive ligands. Current Opinion in Chemical Biology. 54: 76-84. PMID 32146330 DOI: 10.1016/J.Cbpa.2020.02.001  0.405
2019 McCutcheon DC, Lee G, Carlos AJ, Montgomery JE, Moellering RE. Photoproximity Profiling of Protein-Protein Interactions in Cells. Journal of the American Chemical Society. PMID 31820968 DOI: 10.1021/Jacs.9B06528  0.626
2019 Li G, Moellering RE. Chemical probes for spatially resolved measurement of active enzymes in single cells. Methods in Enzymology. 628: 243-262. PMID 31668232 DOI: 10.1016/Bs.Mie.2019.06.017  0.452
2019 Li G, Eckert MA, Chang JW, Montgomery JE, Chryplewicz A, Lengyel E, Moellering RE. Ultrasensitive, multiplexed chemoproteomic profiling with soluble activity-dependent proximity ligation. Proceedings of the National Academy of Sciences of the United States of America. PMID 31591248 DOI: 10.1073/Pnas.1912934116  0.615
2019 Montgomery JE, Donnelly JA, Fanning SW, Speltz TE, Shangguan X, Coukos JS, Greene GL, Moellering RE. Versatile peptide macrocyclization with Diels-Alder cycloadditions. Journal of the American Chemical Society. PMID 31523967 DOI: 10.1021/Jacs.9B07578  0.325
2019 Huang JX, Lee G, Cavanaugh KE, Chang JW, Gardel ML, Moellering RE. High throughput discovery of functional protein modifications by Hotspot Thermal Profiling. Nature Methods. PMID 31384043 DOI: 10.1038/S41592-019-0499-3  0.675
2019 Chang JW, Moellering RE. No Bones About It: Small Molecules for Bone Regeneration. Cell Chemical Biology. 26: 911-912. PMID 31323220 DOI: 10.1016/J.Chembiol.2019.06.007  0.463
2019 Eckert MA, Coscia F, Chryplewicz A, Chang JW, Hernandez KM, Pan S, Tienda SM, Nahotko DA, Li G, Blaženović I, Lastra RR, Curtis M, Yamada SD, Perets R, McGregor SM, ... ... Moellering RE, et al. Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts. Nature. PMID 31043742 DOI: 10.1038/S41586-019-1173-8  0.529
2019 Li G, Moellering R. A concise, modular antibody-oligonucleotide conjugation strategy based on disuccinimidyl ester activation chemistry. Chembiochem : a European Journal of Chemical Biology. PMID 30767357 DOI: 10.1002/Cbic.201900027  0.322
2019 Li G, Moellering RE. Abstract 1142: An activity-dependent proximity ligation platform for spatially resolved and multiplexed quantifications of active enzymes in single cells Cancer Research. 79: 1142-1142. DOI: 10.1158/1538-7445.Am2019-1142  0.446
2018 Bollong MJ, Lee G, Coukos JS, Yun H, Zambaldo C, Chang JW, Chin EN, Ahmad I, Chatterjee AK, Lairson LL, Schultz PG, Moellering RE. A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. Nature. PMID 30323285 DOI: 10.1038/S41586-018-0622-0  0.684
2018 Chang JW, Lee G, Montgomery JE, Moellering R. Chemoproteomic Profiling of Phosphoaspartate Modifications in Prokaryotes. Angewandte Chemie (International Ed. in English). PMID 30231186 DOI: 10.1002/Anie.201809059  0.666
2018 Yang H, Swartz AM, Park HJ, Srivastava P, Ellis-Guardiola K, Upp DM, Lee G, Belsare K, Gu Y, Zhang C, Moellering RE, Lewis JC. Evolving artificial metalloenzymes via random mutagenesis. Nature Chemistry. 10: 318-324. PMID 29461523 DOI: 10.1038/Nchem.2927  0.596
2017 Li G, Montgomery JE, Eckert MA, Chang JW, Tienda SM, Lengyel E, Moellering RE. An activity-dependent proximity ligation platform for spatially resolved quantification of active enzymes in single cells. Nature Communications. 8: 1775. PMID 29176560 DOI: 10.1038/S41467-017-01854-0  0.569
2017 Li G, Montgomery JE, Eckert MA, Chang JW, Tienda SM, Lengyel E, Moellering RE. An activity-dependent proximity ligation platform for spatially resolved quantification of active enzymes in single cells. Nature Communications. 8: 1775. PMID 29176560 DOI: 10.1038/S41467-017-01854-0  0.569
2017 KleinJan A, Tindemans I, Montgomery JE, Lukkes M, de Bruijn MJW, van Nimwegen M, Bergen I, Moellering RE, Hoogsteden HC, Boon L, Amsen D, Hendriks RW. The Notch Pathway Inhibitor SAHM1 Abrogates the Hallmarks of Allergic Asthma. The Journal of Allergy and Clinical Immunology. PMID 29111218 DOI: 10.1016/J.Jaci.2017.08.042  0.3
2017 Mitra S, Montgomery JE, Kolar MJ, Li G, Jeong KJ, Peng B, Verdine GL, Mills GB, Moellering RE. Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer. Nature Communications. 8: 660. PMID 28939823 DOI: 10.1038/S41467-017-00888-8  0.59
2016 Chang JW, Lee G, Coukos JS, Moellering RE. Profiling reactive metabolites via chemical trapping and targeted mass spectrometry. Analytical Chemistry. PMID 27314642 DOI: 10.1021/Acs.Analchem.6B02009  0.654
2015 Chu Q, Moellering RE, Hilinski GJ, Kim YW, Grossmann TN, Yeh JTH, Verdine GL. Towards understanding cell penetration by stapled peptides Medchemcomm. 6: 111-119. DOI: 10.1039/C4Md00131A  0.536
2013 Moellering RE, Cravatt BF. Functional lysine modification by an intrinsically reactive primary glycolytic metabolite. Science (New York, N.Y.). 341: 549-53. PMID 23908237 DOI: 10.1126/Science.1238327  0.564
2012 Grossmann TN, Yeh JT, Bowman BR, Chu Q, Moellering RE, Verdine GL. Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin. Proceedings of the National Academy of Sciences of the United States of America. 109: 17942-7. PMID 23071338 DOI: 10.1073/Pnas.1208396109  0.584
2012 Moellering RE, Cravatt BF. How chemoproteomics can enable drug discovery and development. Chemistry & Biology. 19: 11-22. PMID 22284350 DOI: 10.1016/J.Chembiol.2012.01.001  0.509
2012 Chang JW, Moellering RE, Cravatt BF. An activity-based imaging probe for the integral membrane hydrolase KIAA1363. Angewandte Chemie (International Ed. in English). 51: 966-70. PMID 22162147 DOI: 10.1002/Anie.201107236  0.638
2010 Moellering RE, Cornejo M, Davis TN, Bianco CD, Aster JC, Blacklow SC, Kung AL, Gilliland DG, Verdine GL, Bradner JE. Erratum: Direct inhibition of the NOTCH transcription factor complex Nature. 463: 384-384. DOI: 10.1038/Nature08660  0.481
2010 Moellering R, Shen Y, Wiest O, Bradner J, Verdine G. 69 Computational modeling and molecular optimization of stabilized alpha-helical peptides targeting NOTCH-CSL transcriptional complexes European Journal of Cancer Supplements. 8: 30. DOI: 10.1016/S1359-6349(10)71774-2  0.468
2009 Moellering RE, Cornejo M, Davis TN, Del Bianco C, Aster JC, Blacklow SC, Kung AL, Gilliland DG, Verdine GL, Bradner JE. Direct inhibition of the NOTCH transcription factor complex. Nature. 462: 182-8. PMID 19907488 DOI: 10.1038/Nature08543  0.588
2008 Moellering RE, Black KC, Krishnamurty C, Baggett BK, Stafford P, Rain M, Gatenby RA, Gillies RJ. Acid treatment of melanoma cells selects for invasive phenotypes. Clinical & Experimental Metastasis. 25: 411-25. PMID 18301995 DOI: 10.1007/S10585-008-9145-7  0.302
2008 Ponduru S, Moellering R, Greenberg E, Shen JPY, Stanton BZ, Bradner JE. Discovery and Characterization of Macrocyclic Thiopeptide Proteasome Inhibitors for Hematologic Malignancies Blood. 112: 3669-3669. DOI: 10.1182/Blood.V112.11.3669.3669  0.447
2007 Moellering R, Cornejo M, Rocknik J, Hancock M, DelBianco C, Blacklow S, Gilliland G, Verdine G, Bradner J. Direct Inhibition of the Notch Transactivation Complex with Synthetic Constrained Peptides in T-Cell Acute Lymphoblastic Leukemia. Blood. 110: 2819-2819. DOI: 10.1182/Blood.V110.11.2819.2819  0.586
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