| Year |
Citation |
Score |
| 2024 |
Pitman C, Santiago-McRae E, Lohia R, Bassi K, Joseph TT, Hansen MEB, Brannigan G. The blobulator: a webtool for identification and visual exploration of hydrophobic modularity in protein sequences. Biorxiv : the Preprint Server For Biology. PMID 38293114 DOI: 10.1101/2024.01.15.575761 |
0.695 |
|
| 2024 |
Joseph TT, Bu W, Haji-Ghassemi O, Chen YS, Woll K, Allen PD, Brannigan G, van Petegem F, Eckenhoff RG. Propofol directly binds and inhibits skeletal muscle ryanodine receptor 1 (RyR1). Biorxiv : the Preprint Server For Biology. PMID 38260485 DOI: 10.1101/2024.01.10.575040 |
0.733 |
|
| 2024 |
Dalal V, Arcario MJ, Petroff JT, Tan BK, Dietzen NM, Rau MJ, Fitzpatrick JAJ, Brannigan G, Cheng WWL. Lipid nanodisc scaffold and size alter the structure of a pentameric ligand-gated ion channel. Nature Communications. 15: 25. PMID 38167383 DOI: 10.1038/s41467-023-44366-w |
0.374 |
|
| 2022 |
Petroff JT, Dietzen NM, Santiago-McRae E, Deng B, Washington MS, Chen LJ, Trent Moreland K, Deng Z, Rau M, Fitzpatrick JAJ, Yuan P, Joseph TT, Hénin J, Brannigan G, Cheng WWL. Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation. Nature Communications. 13: 7017. PMID 36385237 DOI: 10.1038/s41467-022-34813-5 |
0.822 |
|
| 2022 |
Lohia R, Hansen MEB, Brannigan G. Contiguously hydrophobic sequences are functionally significant throughout the human exome. Proceedings of the National Academy of Sciences of the United States of America. 119: e2116267119. PMID 35294280 DOI: 10.1073/pnas.2116267119 |
0.759 |
|
| 2022 |
Dietzen NM, Arcario MJ, Chen LJ, Petroff JT, Moreland KT, Krishnan K, Brannigan G, Covey DF, Cheng WW. Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites. Elife. 11. PMID 34982031 DOI: 10.7554/eLife.74306 |
0.347 |
|
| 2021 |
Sharp L, Brannigan G. Spontaneous lipid binding to the nicotinic acetylcholine receptor in a native membrane. The Journal of Chemical Physics. 154: 185102. PMID 34241006 DOI: 10.1063/5.0046333 |
0.375 |
|
| 2021 |
Joseph TT, Bu W, Lin W, Zoubak L, Yeliseev A, Liu R, Eckenhoff RG, Brannigan G. Ketamine Metabolite (2,6)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors. Acs Chemical Neuroscience. PMID 33905229 DOI: 10.1021/acschemneuro.0c00741 |
0.769 |
|
| 2020 |
Lohia R, Bassi K, Hansen M, Brannigan G. Disease Associated Mutations in Intrinsically Disordered Proteins Show Evidence of Enrichment in Hydrophobic Blobs Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.1280 |
0.772 |
|
| 2019 |
Böhm R, Amodeo GF, Murlidaran S, Chavali S, Wagner G, Winterhalter M, Brannigan G, Hiller S. The Structural Basis for Low Conductance in the Membrane Protein VDAC upon β-NADH Binding and Voltage Gating. Structure (London, England : 1993). PMID 31862297 DOI: 10.1016/J.Str.2019.11.015 |
0.813 |
|
| 2019 |
Tong A, Petroff JT, Hsu FF, Schmidpeter PA, Nimigean CM, Sharp L, Brannigan G, Cheng WW. Direct binding of phosphatidylglycerol at specific sites modulates desensitization of a ligand-gated ion channel. Elife. 8. PMID 31724949 DOI: 10.7554/Elife.50766 |
0.517 |
|
| 2019 |
McKinstry-Wu A, Woll KA, Joseph T, Bu W, White ER, Bhanu NV, Garcia BA, Brannigan G, Dailey WP, Eckenhoff RG. Azi-medetomidine: Synthesis and Characterization of a Novel α2 Adrenergic Photoaffinity Ligand. Acs Chemical Neuroscience. PMID 31638765 DOI: 10.1021/Acschemneuro.9B00484 |
0.794 |
|
| 2019 |
Lohia R, Salari R, Brannigan G. Sequence specificity despite intrinsic disorder: How a disease-associated Val/Met polymorphism rearranges tertiary interactions in a long disordered protein. Plos Computational Biology. 15: e1007390. PMID 31626641 DOI: 10.1371/Journal.Pcbi.1007390 |
0.797 |
|
| 2019 |
Hénault CM, Govaerts C, Spurny R, Brams M, Estrada-Mondragon A, Lynch J, Bertrand D, Pardon E, Evans GL, Woods K, Elberson BW, Cuello LG, Brannigan G, Nury H, Steyaert J, et al. A lipid site shapes the agonist response of a pentameric ligand-gated ion channel. Nature Chemical Biology. PMID 31591563 DOI: 10.1038/S41589-019-0369-4 |
0.525 |
|
| 2019 |
Moffett SX, Klein EA, Brannigan G, Martin JV. L-3,3',5-triiodothyronine and pregnenolone sulfate inhibit Torpedo nicotinic acetylcholine receptors. Plos One. 14: e0223272. PMID 31584962 DOI: 10.1371/Journal.Pone.0223272 |
0.376 |
|
| 2019 |
Woods K, Sharp L, Brannigan G. Untangling Direct and Domain-Mediated Interactions Between Nicotinic Acetylcholine Receptors in DHA-Rich Membranes. The Journal of Membrane Biology. PMID 31321460 DOI: 10.1007/S00232-019-00079-0 |
0.384 |
|
| 2019 |
Sharp L, Salari R, Brannigan G. Boundary lipids of the nicotinic acetylcholine receptor: Spontaneous partitioning via coarse-grained molecular dynamics simulation. Biochimica Et Biophysica Acta. Biomembranes. PMID 30664881 DOI: 10.1016/J.Bbamem.2019.01.005 |
0.75 |
|
| 2019 |
Tong A, Petroff JT, Hsu F, Schmidpeter PA, Nimigean CM, Sharp L, Brannigan G, Cheng WW. Author response: Direct binding of phosphatidylglycerol at specific sites modulates desensitization of a ligand-gated ion channel Elife. DOI: 10.7554/Elife.50766.024 |
0.466 |
|
| 2019 |
Lohia R, Brannigan G. Conformational Effects of a Disease-Associated Hydrophobic-to-Hydrophobic Substitution and Histidine Protonation State Located at the Midpoint of the Intrinsically Disordered Region of proBDNF Biophysical Journal. 116: 179a. DOI: 10.1016/J.Bpj.2018.11.993 |
0.784 |
|
| 2019 |
Fiorin G, Brannigan G, Hénin J. New Tools for Conformational and Binding Free Energy Simulations Biophysical Journal. 116: 142a. DOI: 10.1016/J.Bpj.2018.11.786 |
0.366 |
|
| 2019 |
Woods KN, Sharp LM, Brannigan G. Nicotinic Acetylcholine Receptor Clustering in DHA-Enriched Domains Biophysical Journal. 116: 434a. DOI: 10.1016/J.Bpj.2018.11.2338 |
0.307 |
|
| 2019 |
Sharp LM, Salari R, Brannigan G. Boundary Lipids of the Nicotinic Acetylcholine Receptor in Quasi-Native Membranes Biophysical Journal. 116: 220a. DOI: 10.1016/J.Bpj.2018.11.1215 |
0.735 |
|
| 2018 |
Salari R, Joseph T, Lohia R, Hénin J, Brannigan G. A streamlined, general approach for computing ligand binding free energies and its application to GPCR-bound cholesterol. Journal of Chemical Theory and Computation. PMID 30358394 DOI: 10.1021/Acs.Jctc.8B00447 |
0.799 |
|
| 2018 |
Murlidaran S, Brannigan G. Physical Accuracy Leads to Biological Relevance: Best Practices For Simulating Ligand-Gated Ion Channels Interacting With General Anesthetics. Methods in Enzymology. 602: 3-24. PMID 29588036 DOI: 10.1016/Bs.Mie.2018.02.001 |
0.819 |
|
| 2018 |
Sharp L, Brannigan G. Interactions of Nicotinic Acetylcholine Receptors with Cholesterol and Polyunsaturated Fatty Acids in Model, Native-Like, and Oocyte Membranes Biophysical Journal. 114: 610a-611a. DOI: 10.1016/J.Bpj.2017.11.3337 |
0.358 |
|
| 2018 |
Lohia R, Brannigan G. Conformational Effects of Various Hydrophobic-to-Hydrophobic Substitution Located at the Midpoint of the Intrinsically Disordered Region of ProBDNF Biophysical Journal. 114: 591a. DOI: 10.1016/J.Bpj.2017.11.3229 |
0.785 |
|
| 2018 |
Woods KN, Sharp LM, Brannigan G. Oligomerization of Nicotinic Acetylcholine Receptors in Domain-Forming Membranes Biophysical Journal. 114: 340a. DOI: 10.1016/J.Bpj.2017.11.1900 |
0.345 |
|
| 2018 |
Joseph TT, Eckenhoff RG, Brannigan G. The pH Dependence of Ketamine Binding to G-Protein Coupled Receptors Biophysical Journal. 114: 226a. DOI: 10.1016/J.Bpj.2017.11.1260 |
0.779 |
|
| 2017 |
Brannigan G. Direct Interactions of Cholesterol With Pentameric Ligand-Gated Ion Channels: Testable Hypotheses From Computational Predictions. Current Topics in Membranes. 80: 163-186. PMID 28863815 DOI: 10.1016/Bs.Ctm.2017.06.002 |
0.485 |
|
| 2017 |
Murlidaran S, Salari R, Hénin J, Brannigan G. Relative Affinities of General Anesthetics for Pseudo-Symmetric Intersubunit Binding Sites of Heteromeric GABA(A) Receptors Biophysical Journal. 112: 555a. DOI: 10.1016/J.Bpj.2016.11.2994 |
0.817 |
|
| 2017 |
Brannigan G. Modulation of Gaba(A) Receptors by General Anesthetics: A Combinatoric Model Predicts Twenty Years of Concentration-Response Data (With a Few Interesting Exceptions) Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.2571 |
0.324 |
|
| 2017 |
Sharp LM, Brannigan G. Interactions of Nicotinic Acetylcholine Receptors with Liquid-Disordered Domains Rich in n-3 Polyunsaturated Fatty Acids Biophysical Journal. 112: 225a. DOI: 10.1016/J.Bpj.2016.11.1239 |
0.412 |
|
| 2017 |
Lohia R, Salari R, Brannigan G. Mechanism Underlying Conformational Effects of a Disease-Associated Hydrophobic-to-Hydrophobic Substitution on an Intrinsically Disordered Region Biophysical Journal. 112: 207a. DOI: 10.1016/J.Bpj.2016.11.1145 |
0.789 |
|
| 2016 |
Woll KA, Dailey WP, Brannigan G, Eckenhoff RG. Shedding Light on Anesthetic Mechanisms: Application of Photoaffinity Ligands. Anesthesia and Analgesia. PMID 27464974 DOI: 10.1213/Ane.0000000000001365 |
0.567 |
|
| 2016 |
Woll KA, Murlidaran S, Pinch BJ, Hénin J, Wang X, Salari R, Covarrubias M, Dailey WP, Brannigan G, Garcia BA, Eckenhoff RG. A Novel Bifunctional Alkylphenol Anesthetic Allows Characterization of GABAA Receptor Subunit Binding Selectivity in Synaptosomes. The Journal of Biological Chemistry. PMID 27462076 DOI: 10.1074/Jbc.M116.736975 |
0.804 |
|
| 2016 |
Shashank Chavali S, Brannigan G, Salari R. Effects of Excluded Volume and Induced N-Terminal Conformational Change on Ion Translocation across VDAC Biophysical Journal. 110: 609a. DOI: 10.1016/J.Bpj.2015.11.3251 |
0.773 |
|
| 2016 |
Sharp LM, Salari R, Brannigan G. Effects of Quasi-Native Lipid Composition on Membrane Domain Formation Induced by Nicotinic Acetylcholine Receptors Biophysical Journal. 110: 604a. DOI: 10.1016/J.Bpj.2015.11.3225 |
0.765 |
|
| 2016 |
Lohia R, Salari R, Brannigan G. Effects of a Structured Domain on the Conformational Ensemble of Disordered Regions in Brain-Derived Neurotrophic Factor Biophysical Journal. 110: 559a. DOI: 10.1016/J.Bpj.2015.11.2989 |
0.8 |
|
| 2016 |
Murlidaran S, Salari R, Hénin J, Brannigan G. Relative Affinities of Positive and Negative Modulators of Heteromeric GABA(A) Receptors for Pseudo-Symmetric Intersubunit Binding Sites Biophysical Journal. 110: 454a. DOI: 10.1016/J.Bpj.2015.11.2436 |
0.817 |
|
| 2016 |
Salari R, Brannigan G. Absolute Affinity Calculations for Cholesterol Binding to G-Protein Coupled Receptors (GPCR) Biophysical Journal. 110: 423a. DOI: 10.1016/J.Bpj.2015.11.2288 |
0.784 |
|
| 2015 |
Westergard T, Salari R, Martin JV, Brannigan G. Correction: Interactions of L-3,5,3'-Triiodothyronine, Allopregnanolone, and Ivermectin with the GABAA Receptor: Evidence for Overlapping Intersubunit Binding Modes. Plos One. 10: e0142514. PMID 26529248 DOI: 10.1371/journal.pone.0142514 |
0.732 |
|
| 2015 |
Westergard T, Salari R, Martin JV, Brannigan G. Interactions of L-3,5,4'-Triiodothyronine, Allopregnanolone, and Ivermectin with the GABAA Receptor: Evidence for Overlapping Intersubunit Binding Modes. Plos One. 10: e0139072. PMID 26421724 DOI: 10.1371/Journal.Pone.0139072 |
0.781 |
|
| 2015 |
Carswell CL, Hénault CM, Murlidaran S, Therien JP, Juranka PF, Surujballi JA, Brannigan G, Baenziger JE. Role of the Fourth Transmembrane α Helix in the Allosteric Modulation of Pentameric Ligand-Gated Ion Channels. Structure (London, England : 1993). 23: 1655-64. PMID 26235032 DOI: 10.1016/J.Str.2015.06.020 |
0.808 |
|
| 2015 |
Cournia Z, Allen TW, Andricioaei I, Antonny B, Baum D, Brannigan G, Buchete NV, Deckman JT, Delemotte L, Del Val C, Friedman R, Gkeka P, Hege HC, Hénin J, Kasimova MA, et al. Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory. The Journal of Membrane Biology. 248: 611-40. PMID 26063070 DOI: 10.1007/S00232-015-9802-0 |
0.778 |
|
| 2015 |
Hénault CM, Carswell CL, Murlidaran S, Therien JD, Juranka PF, Surujballi JA, Brannigan G, Baenziger JE. Role of the Transmembrane α-Helix M4 in the Potentiation of Pentameric Ligand-Gated Ion Channels Biophysical Journal. 108: 432a. DOI: 10.1016/J.Bpj.2014.11.2359 |
0.796 |
|
| 2015 |
Lohia R, Salari R, Brannigan G. Prediction of the Effects of the Val66Met Polymorphism and Adjacent Structured Domains on the Conformational Ensemble of an Intrinsically Disordered Protein, Brain-Derived Neurotrophic Factor Biophysical Journal. 108: 386a-387a. DOI: 10.1016/J.Bpj.2014.11.2118 |
0.789 |
|
| 2015 |
Salari R, Henin J, Brannigan G. Calculation of Cholesterol Binding Affinity for Pentameric Ligand-Gated Ion Channels Biophysical Journal. 108: 317a. DOI: 10.1016/J.Bpj.2014.11.1725 |
0.799 |
|
| 2015 |
Murlidaran S, Salari R, Brannigan G. Affinity Calculations for Lipophilic Modulators Binding to Isolated Sites on GABA(A) Receptors Biophysical Journal. 108: 19a. DOI: 10.1016/J.Bpj.2014.11.131 |
0.809 |
|
| 2014 |
Salari R, Murlidaran S, Brannigan G. Pentameric Ligand-gated Ion Channels : Insights from Computation. Molecular Simulation. 40: 821-829. PMID 25931676 DOI: 10.1080/08927022.2014.896462 |
0.808 |
|
| 2014 |
Weiser BP, Salari R, Eckenhoff RG, Brannigan G. Computational investigation of cholesterol binding sites on mitochondrial VDAC. The Journal of Physical Chemistry. B. 118: 9852-60. PMID 25080204 DOI: 10.1021/Jp504516A |
0.824 |
|
| 2014 |
Hénin J, Salari R, Murlidaran S, Brannigan G. A predicted binding site for cholesterol on the GABAA receptor Biophysical Journal. 106: 1938-1949. PMID 24806926 DOI: 10.1016/J.Bpj.2014.03.024 |
0.812 |
|
| 2014 |
Salari R, Murlidaran S, Brannigan G. Pentameric ligand-gated ion channels: Insights from computation Molecular Simulation. 40: 821-829. DOI: 10.1080/08927022.2014.896462 |
0.794 |
|
| 2014 |
Weiser BP, Salari R, Eckenhoff RG, Brannigan G. Computational investigation of cholesterol binding sites on mitochondrial VDAC Journal of Physical Chemistry B. 118: 9852-9860. DOI: 10.1021/jp504516a |
0.526 |
|
| 2014 |
Carswell CL, Hénault CM, Murlidaran S, Therien JPD, Juranka PF, Surujballi JA, Brannigan G, Baenziger JE. Role of the Fourth Transmembrane α Helix in the Allosteric Modulation of Pentameric Ligand-Gated Ion Channels Structure. DOI: 10.1016/j.str.2015.06.020 |
0.805 |
|
| 2014 |
Murlidaran S, Salari R, Brannigan G. Effects of Disease-Associated Mutations on the Conformations of GABA(A) Receptors Biophysical Journal. 106: 550a. DOI: 10.1016/J.Bpj.2013.11.3063 |
0.794 |
|
| 2014 |
Lohia R, Salari R, Brannigan G. Prediction of the Effects of the Val66Met Polymorphism on the Conformational Ensemble of an Intrinsically Disordered Protein, Brain-Derived Neurotrophic Factor Biophysical Journal. 106: 425a. DOI: 10.1016/J.Bpj.2013.11.2397 |
0.797 |
|
| 2013 |
Hénin J, Brannigan G. A Mechanism for Potentiation of the GABA(A) Receptor by Bound Cholesterol Biophysical Journal. 104: 638a. DOI: 10.1016/J.Bpj.2012.11.3523 |
0.474 |
|
| 2013 |
Westergard T, Henin J, Martin J, Brannigan G. Analysis of the Interactions between GABA(A) Receptors and T3 using Electrophysiology and Molecular Dynamics Simulations Biophysical Journal. 104: 638a. DOI: 10.1016/J.Bpj.2012.11.3522 |
0.424 |
|
| 2012 |
LeBard DN, Hénin J, Eckenhoff RG, Klein ML, Brannigan G. General anesthetics predicted to block the GLIC pore with micromolar affinity Plos Computational Biology. 8. PMID 22693438 DOI: 10.1371/Journal.Pcbi.1002532 |
0.826 |
|
| 2012 |
Henin J, Brannigan G. Interactions of GABAA Receptors with Steroid-Like Positive and Negative Modulators Biophysical Journal. 102: 111a. DOI: 10.1016/J.Bpj.2011.11.625 |
0.46 |
|
| 2011 |
Brannigan G, Henin J, Eckenhoff R, Klein M. Transmembrane Domain Packing in Cys-Loop Receptors: What Can we Learn from Prokaryotes? Biophysical Journal. 100: 277a. DOI: 10.1016/J.Bpj.2010.12.1722 |
0.689 |
|
| 2011 |
LeBard D, Brannigan G, Henin J, Eckenhoff R, Klein M. Dominant Site Involved in Inhibition of Targets by Anesthetics Suggested Through Novel Free Energy Perturbation Calculations Biophysical Journal. 100: 195a. DOI: 10.1016/J.Bpj.2010.12.1282 |
0.828 |
|
| 2010 |
Brannigan G, LeBard DN, Hénin J, Eckenhoff RG, Klein ML. Multiple binding sites for the general anesthetic isoflurane identified in the nicotinic acetylcholine receptor transmembrane domain Proceedings of the National Academy of Sciences of the United States of America. 107: 14122-14127. PMID 20660787 DOI: 10.1073/Pnas.1008534107 |
0.834 |
|
| 2010 |
Hénin J, Brannigan G, Dailey WP, Eckenhoff R, Klein ML. An atomistic model for simulations of the general anesthetic isoflurane. The Journal of Physical Chemistry. B. 114: 604-12. PMID 19924847 DOI: 10.1021/Jp9088035 |
0.804 |
|
| 2010 |
Brannigan G, Lebard D, Henin J, Eckenhoff R, Klein ML. Multiple Modes of Interaction between the Nicotinic Acetylcholine Receptor and Isoflurane Observed Through Long Time Simulations Biophysical Journal. 98: 134a. DOI: 10.1016/J.Bpj.2009.12.722 |
0.851 |
|
| 2010 |
LeBard DN, Brannigan G, Hénin J, Eckenhoff R, Klein ML. Effects of Isoflurane Binding in the Pore of a Ligand-Gated Ion Channel Biophysical Journal. 98: 133a. DOI: 10.1016/J.Bpj.2009.12.719 |
0.835 |
|
| 2009 |
Vedula LS, Brannigan G, Economou NJ, Xi J, Hall MA, Liu R, Rossi MJ, Dailey WP, Grasty KC, Klein ML, Eckenhoff RG, Loll PJ. A unitary anesthetic binding site at high resolution. The Journal of Biological Chemistry. 284: 24176-84. PMID 19605349 DOI: 10.1074/Jbc.M109.017814 |
0.724 |
|
| 2009 |
Butts CA, Xi J, Brannigan G, Saad AA, Venkatachalan SP, Pearce RA, Klein ML, Eckenhoff RG, Dmochowski IJ. Identification of a fluorescent general anesthetic, 1-aminoanthracene. Proceedings of the National Academy of Sciences of the United States of America. 106: 6501-6. PMID 19346473 DOI: 10.1073/Pnas.0810590106 |
0.592 |
|
| 2008 |
Brannigan G, Hénin J, Law R, Eckenhoff R, Klein ML. Embedded cholesterol in the nicotinic acetylcholine receptor Proceedings of the National Academy of Sciences of the United States of America. 105: 14418-14423. PMID 18768796 DOI: 10.1073/Pnas.0803029105 |
0.841 |
|
| 2007 |
Brannigan G, Brown FLH. Contributions of Gaussian curvature and nonconstant lipid volume to protein deformation of lipid bilayers Biophysical Journal. 92: 864-876. PMID 17098794 DOI: 10.1529/Biophysj.106.094953 |
0.319 |
|
| 2006 |
Brannigan G, Brown FLH. A consistent model for thermal fluctuations and protein-induced deformations in lipid bilayers Biophysical Journal. 90: 1501-1520. PMID 16326916 DOI: 10.1529/Biophysj.105.075838 |
0.348 |
|
| 2005 |
Brannigan G, Philips PF, Brown FLH. Flexible lipid bilayers in implicit solvent Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 72. PMID 16090009 DOI: 10.1103/Physreve.72.011915 |
0.321 |
|
| 2005 |
Brannigan G, Brown FL. Composition dependence of bilayer elasticity. The Journal of Chemical Physics. 122: 074905. PMID 15743268 DOI: 10.1063/1.1851983 |
0.596 |
|
| 2004 |
Brannigan G, Tamboli AC, Brown FL. The role of molecular shape in bilayer elasticity and phase behavior. The Journal of Chemical Physics. 121: 3259-71. PMID 15291638 DOI: 10.1063/1.1770569 |
0.596 |
|
| 2004 |
Brannigan G, Brown FLH. Solvent-free simulations of fluid membrane bilayers. The Journal of Chemical Physics.. 120: 1059-1071. PMID 15267943 DOI: 10.1063/1.1625913 |
0.314 |
|
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