Ottavio Arancio, M.D., Ph.D. - Publications

Affiliations: 
Pathology and Cell Biology Columbia University, New York, NY 

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Year Citation  Score
2023 Haut F, Argyrousi EK, Arancio O. Re-Arranging the Puzzle between the Amyloid-Beta and Tau Pathology: An APP-Centric Approach. International Journal of Molecular Sciences. 25. PMID 38203429 DOI: 10.3390/ijms25010259  0.333
2023 Zuccarello E, Zhang H, Acquarone E, Pham D, Staniszewski A, Deng S, Landry DW, Arancio O, Fiorito J. Optimizing metabolic stability of phosphodiesterase 5 inhibitors: discovery of a potent N-(pyridin-3-ylmethyl)quinoline derivative targeting synaptic plasticity. Bioorganic & Medicinal Chemistry Letters. 129409. PMID 37453616 DOI: 10.1016/j.bmcl.2023.129409  0.312
2023 Puliatti G, Li Puma DD, Aceto G, Lazzarino G, Acquarone E, Mangione R, D'Adamio L, Ripoli C, Arancio O, Piacentini R, Grassi C. Intracellular accumulation of tau oligomers in astrocytes and their synaptotoxic action rely on Amyloid Precursor Protein Intracellular Domain-dependent expression of Glypican-4. Progress in Neurobiology. 227: 102482. PMID 37321444 DOI: 10.1016/j.pneurobio.2023.102482  0.352
2023 Falcicchia C, Tozzi F, Gabrielli M, Amoretti S, Masini G, Nardi G, Guglielmo S, Ratto GM, Arancio O, Verderio C, Origlia N. Microglial extracellular vesicles induce Alzheimer's disease-related cortico-hippocampal network dysfunction. Brain Communications. 5: fcad170. PMID 37288314 DOI: 10.1093/braincomms/fcad170  0.348
2022 Tropea MR, Gulisano W, Vacanti V, Arancio O, Puzzo D, Palmeri A. Nitric oxide/cGMP/CREB pathway and amyloid-beta crosstalk: From physiology to Alzheimer's disease. Free Radical Biology & Medicine. 193: 657-668. PMID 36400326 DOI: 10.1016/j.freeradbiomed.2022.11.022  0.393
2022 Selles MC, Fortuna JTS, Cercato MC, Santos LE, Domett L, Bitencourt ALB, Carraro MF, Souza AS, Janickova H, Azevedo CV, Campos HC, de Souza JM, Alves-Leon S, Prado VF, Prado MAM, ... ... Arancio O, et al. AAV-mediated neuronal expression of an scFv antibody selective for Aβ oligomers protects synapses and rescues memory in Alzheimer models. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 36369741 DOI: 10.1016/j.ymthe.2022.11.002  0.373
2022 Wu X, Sosunov AA, Lado W, Teoh JJ, Ham A, Li H, Al-Dalahmah O, Gill BJA, Arancio O, Schevon CA, Frankel WN, McKhann GM, Sulzer D, Goldman JE, Tang G. Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex. Cell Reports. 40: 111085. PMID 35858542 DOI: 10.1016/j.celrep.2022.111085  0.302
2022 Gabrielli M, Prada I, Joshi P, Falcicchia C, D'Arrigo G, Rutigliano G, Battocchio E, Zenatelli R, Tozzi F, Radeghieri A, Arancio O, Origlia N, Verderio C. Microglial large extracellular vesicles propagate early synaptic dysfunction in Alzheimer's disease. Brain : a Journal of Neurology. PMID 35254410 DOI: 10.1093/brain/awac083  0.411
2021 Tropea MR, Li Puma DD, Melone M, Gulisano W, Arancio O, Grassi C, Conti F, Puzzo D. Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer's disease-like pathology. Progress in Neurobiology. 102154. PMID 34453977 DOI: 10.1016/j.pneurobio.2021.102154  0.405
2021 Gnanaprakash M, Staniszewski A, Zhang H, Pitstick R, Kavanaugh MP, Arancio O, Nicholls RE. Leucine Carboxyl Methyltransferase 1 Overexpression Protects Against Cognitive and Electrophysiological Impairments in Tg2576 APP Transgenic Mice. Journal of Alzheimer's Disease : Jad. PMID 33459709 DOI: 10.3233/JAD-200462  0.31
2020 Arancio O. What Does the APP Family Do in the Brain? Neuron. 108: 583-585. PMID 33242425 DOI: 10.1016/j.neuron.2020.11.003  0.33
2020 Falcicchia C, Tozzi F, Arancio O, Watterson DM, Origlia N. Involvement of p38 MAPK in Synaptic Function and Dysfunction. International Journal of Molecular Sciences. 21. PMID 32781522 DOI: 10.3390/Ijms21165624  0.489
2020 Puzzo D, Argyrousi EK, Staniszewski A, Zhang H, Calcagno E, Zuccarello E, Acquarone E, Fà M, Li Puma DD, Grassi C, D'Adamio L, Kanaan NM, Fraser PE, Arancio O. Tau is not necessary for amyloid-beta-induced synaptic and memory impairments. The Journal of Clinical Investigation. PMID 32544084 DOI: 10.1172/Jci137040  0.499
2020 Staniszewski A, Zhang H, Asam K, Pitstick R, Kavanaugh MP, Arancio O, Nicholls RE. Reduced expression of the PP2A methylesterase, PME-1, or the PP2A methyltransferase, LCMT-1, alter sensitivity to beta-amyloid induced cognitive and electrophysiological impairments in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 32341098 DOI: 10.1523/Jneurosci.2983-19.2020  0.476
2020 Zuccarello E, Acquarone E, Calcagno E, Argyrousi EK, Deng SX, Landry DW, Arancio O, Fiorito J. Development of novel phosphodiesterase 5 inhibitors for the therapy of alzheimer's disease. Biochemical Pharmacology. 113818. PMID 31978378 DOI: 10.1016/J.Bcp.2020.113818  0.403
2019 Kelschenbach J, He H, Kim BH, Borjabad A, Gu CJ, Chao W, Do M, Sharer LR, Zhang H, Arancio O, Potash MJ, Volsky DJ. Efficient Expression of HIV in Immunocompetent Mouse Brain Reveals a Novel Nonneurotoxic Viral Function in Hippocampal Synaptodendritic Injury and Memory Impairment. Mbio. 10. PMID 31266862 DOI: 10.1128/Mbio.00591-19  0.329
2019 Acquarone E, Argyrousi EK, van den Berg M, Gulisano W, Fà M, Staniszewski A, Calcagno E, Zuccarello E, D'Adamio L, Deng SX, Puzzo D, Arancio O, Fiorito J. Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade. Molecular Neurodegeneration. 14: 26. PMID 31248451 DOI: 10.1186/S13024-019-0326-4  0.469
2019 Gulisano W, Melone M, Ripoli C, Rosaria Tropea M, Li Puma DD, Giunta S, Cocco S, Marcotulli D, Origlia N, Palmeri A, Arancio O, Conti F, Grassi C, Puzzo D. Neuromodulatory action of picomolar extracellular Aβ42 oligomers on pre- and postsynaptic mechanisms underlying synaptic function and memory. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31127002 DOI: 10.1523/Jneurosci.0163-19.2019  0.526
2019 Lourenco MV, Frozza RL, de Freitas GB, Zhang H, Kincheski GC, Ribeiro FC, Gonçalves RA, Clarke JR, Beckman D, Staniszewski A, Berman H, Guerra LA, Forny-Germano L, Meier S, Wilcock DM, ... ... Arancio O, et al. Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models. Nature Medicine. 25: 165-175. PMID 30617325 DOI: 10.1038/S41591-018-0275-4  0.458
2019 Lourenco MV, Arancio O, Ferreira ST, De Felice FG. P2-162: EXERCISE-LINKED FNDC5/IRISIN CORRECTS SYNAPTIC PLASTICITY AND MEMORY DEFECTS IN MOUSE MODELS OF ALZHEIMER'S DISEASE Alzheimer's & Dementia. 15: P637-P638. DOI: 10.1016/J.Jalz.2019.06.2569  0.417
2019 Sellés MC, Fortuna J, Cercato M, Bitencourt A, Souza A, Prado V, Prado M, Sebollela A, Arancio O, Klein W, De Felice F, Jerusalinsky D, Ferreira S. Neuronal expression of NUsc1, a single-chain variable fragment antibody against Ab oligomers, protects synapses and rescues memory in Alzheimer's disease models Ibro Reports. 6: S497. DOI: 10.1016/J.Ibror.2019.07.1558  0.409
2018 Biundo F, d'Abramo C, Tambini MD, Zhang H, Del Prete D, Vitale F, Giliberto L, Arancio O, D'Adamio L. Correction: Abolishing Tau cleavage by caspases at Aspartate causes memory/synaptic plasticity deficits and pre-pathological Tau alterations. Translational Psychiatry. 8: 172. PMID 30171180 DOI: 10.1038/S41398-018-0188-5  0.443
2018 Gulisano W, Melone M, Li Puma DD, Tropea MR, Palmeri A, Arancio O, Grassi C, Conti F, Puzzo D. The effect of amyloid-β peptide on synaptic plasticity and memory is influenced by different isoforms, concentrations, and aggregation status. Neurobiology of Aging. 71: 51-60. PMID 30092511 DOI: 10.1016/J.Neurobiolaging.2018.06.025  0.489
2018 Rutigliano G, Stazi M, Arancio O, Watterson DM, Origlia N. An isoform-selective p38α mitogen-activated protein kinase inhibitor rescues early entorhinal cortex dysfunctions in a mouse model of Alzheimer's disease. Neurobiology of Aging. 70: 86-91. PMID 30007168 DOI: 10.1016/J.Neurobiolaging.2018.06.006  0.418
2018 Teich AF, Sharma E, Barnwell E, Zhang H, Staniszewski A, Utsuki T, Padmaraju V, Mazell C, Tzekou A, Sambamurti K, Arancio O, Maccecchini ML. Translational inhibition of APP by Posiphen: Efficacy, pharmacodynamics, and pharmacokinetics in the APP/PS1 mouse. Alzheimer's & Dementia (New York, N. Y.). 4: 37-45. PMID 29955650 DOI: 10.1016/J.Trci.2017.12.001  0.399
2018 Argyrousi EK, Staniszewski A, Nicholls RE, Arancio O. Preparation of Tau Oligomers After the Protein Extraction from Bacteria and Brain Cortices. Methods in Molecular Biology (Clifton, N.J.). 1779: 85-97. PMID 29886529 DOI: 10.1007/978-1-4939-7816-8_7  0.304
2018 Gulisano W, Tropea MR, Arancio O, Palmeri A, Puzzo D. Sub-efficacious doses of phosphodiesterase 4 and 5 inhibitors improve memory in a mouse model of Alzheimer's disease. Neuropharmacology. PMID 29885420 DOI: 10.1016/J.Neuropharm.2018.06.002  0.392
2018 Gulisano W, Maugeri D, Baltrons MA, Fà M, Amato A, Palmeri A, D'Adamio L, Grassi C, Devanand DP, Honig LS, Puzzo D, Arancio O. Role of Amyloid-β and Tau Proteins in Alzheimer's Disease: Confuting the Amyloid Cascade. Journal of Alzheimer's Disease : Jad. PMID 29865055 DOI: 10.3233/Jad-179935  0.468
2018 Biundo F, Del Prete D, Zhang H, Arancio O, D'Adamio L. A role for tau in learning, memory and synaptic plasticity. Scientific Reports. 8: 3184. PMID 29453339 DOI: 10.1038/S41598-018-21596-3  0.459
2018 Fang F, Yu Q, Arancio O, Chen D, Gore SS, Yan SF, Yan SS. RAGE mediates Aβ accumulation in a mouse model of Alzheimer's disease via modulation of β- and γ-secretase activity. Human Molecular Genetics. PMID 29329433 DOI: 10.1093/Hmg/Ddy017  0.421
2017 Yang S, Pascual-Guiral S, Ponce R, Giménez-Llort L, Baltrons MA, Arancio O, Palacio JR, Clos VM, Yuste VJ, Bayascas JR. Reducing the Levels of Akt Activation by PDK1 Knock-in Mutation Protects Neuronal Cultures against Synthetic Amyloid-Beta Peptides. Frontiers in Aging Neuroscience. 9: 435. PMID 29358916 DOI: 10.3389/Fnagi.2017.00435  0.403
2017 Asam K, Staniszewski A, Zhang H, Melideo SL, Mazzeo A, Voronkov M, Huber KL, Pérez E, Stock M, Stock JB, Arancio O, Nicholls RE. Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer's disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid. Plos One. 12: e0189413. PMID 29253878 DOI: 10.1371/Journal.Pone.0189413  0.458
2017 Knock E, Matsuzaki S, Takamura H, Satoh K, Rooke G, Han K, Zhang H, Staniszewski A, Katayama T, Arancio O, Fraser PE. SUMO1 impact on Alzheimer disease pathology in an amyloid-depositing mouse model. Neurobiology of Disease. 110: 154-165. PMID 29217476 DOI: 10.1016/J.Nbd.2017.11.015  0.466
2017 Knock E, Matsuzaki S, Takamura H, Satoh K, Rooke G, Han K, Zhang H, Staniszewski A, Katayama T, Arancio O, Fraser PE. SUMO1 impact on Alzheimer disease pathology in an amyloid-depositing mouse model. Neurobiology of Disease. 110: 154-165. PMID 29217476 DOI: 10.1016/j.nbd.2017.11.015  0.363
2017 Ortiz-Virumbrales M, Moreno CL, Kruglikov I, Marazuela P, Sproul A, Jacob S, Zimmer M, Paull D, Zhang B, Schadt EE, Ehrlich ME, Tanzi RE, Arancio O, Noggle S, Gandy S. CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2 (N141I) neurons. Acta Neuropathologica Communications. 5: 77. PMID 29078805 DOI: 10.1186/S40478-017-0475-Z  0.352
2017 Fiorito J, Vendome J, Saeed F, Staniszewski A, Zhang H, Yan S, Deng SX, Arancio O, Landry DW. Identification of a Novel 1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine Analog as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer's Disease. Journal of Medicinal Chemistry. PMID 28985058 DOI: 10.1021/Acs.Jmedchem.7B00979  0.334
2017 Martín-Maestro P, Gargini R, A Sproul A, García E, Antón LC, Noggle S, Arancio O, Avila J, García-Escudero V. Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer's Disease-Associated Presenilin 1 Mutation. Frontiers in Molecular Neuroscience. 10: 291. PMID 28959184 DOI: 10.3389/Fnmol.2017.00291  0.396
2017 Biundo F, d'Abramo C, Tambini MD, Zhang H, Del Prete D, Vitale F, Giliberto L, Arancio O, D'Adamio L. Abolishing Tau cleavage by caspases at Aspartate(421) causes memory/synaptic plasticity deficits and pre-pathological Tau alterations. Translational Psychiatry. 7: e1198. PMID 28786980 DOI: 10.1038/Tp.2017.165  0.44
2017 Puzzo D, Piacentini R, Fa' M, Gulisano W, Li Puma DD, Staniszewski A, Zhang H, Tropea MR, Cocco S, Palmeri A, Fraser P, D'Adamio L, Grassi C, Arancio O. LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent. Elife. 6. PMID 28696204 DOI: 10.7554/Elife.26991  0.5
2017 Manassero G, Guglielmotto M, Monteleone D, Vasciaveo V, Butenko O, Tamagno E, Arancio O, Tabaton M. Dual Mechanism of Toxicity for Extracellular Injection of Tau Oligomers versus Monomers in Human Tau Mice. Journal of Alzheimer's Disease : Jad. PMID 28671129 DOI: 10.3233/Jad-170298  0.335
2017 Lacampagne A, Liu X, Reiken S, Bussiere R, Meli AC, Lauritzen I, Teich AF, Zalk R, Saint N, Arancio O, Bauer C, Duprat F, Briggs CA, Chakroborty S, Stutzmann GE, et al. Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer's disease-like pathologies and cognitive deficits. Acta Neuropathologica. PMID 28631094 DOI: 10.1007/S00401-017-1733-7  0.44
2017 Palmeri A, Ricciarelli R, Gulisano W, Rivera D, Rebosio C, Calcagno E, Rosaria Tropea M, Conti S, Das U, Roy S, Pronzato MA, Arancio O, Fedele E, Puzzo D. Amyloid-beta peptide is needed for cGMP-induced long-term potentiation and memory. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28626017 DOI: 10.1523/Jneurosci.3607-16.2017  0.488
2017 Piacentini R, Li Puma DD, Mainardi M, Lazzarino G, Tavazzi B, Arancio O, Grassi C. Reduced Gliotransmitter Release from Astrocytes Mediates Tau-Induced Synaptic Dysfunction in Cultured Hippocampal Neurons. Glia. PMID 28519902 DOI: 10.1002/Glia.23163  0.472
2017 Ricciarelli R, Brullo C, Prickaerts J, Arancio O, Villa C, Rebosio C, Calcagno E, Balbi M, van Hagen BT, Argyrousi EK, Zhang H, Pronzato MA, Bruno O, Fedele E. Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer's disease. Scientific Reports. 7: 46320. PMID 28402318 DOI: 10.1038/Srep46320  0.394
2017 Puzzo D, Piacentini R, Fá M, Gulisano W, Puma DDL, Staniszewski A, Zhang H, Tropea MR, Cocco S, Palmeri A, Fraser P, D'Adamio L, Grassi C, Arancio O. Author response: LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent Elife. DOI: 10.7554/Elife.26991.025  0.436
2017 Van Eldik LJ, Roy SM, Arancio O, Watterson DM. A PLATFORM FOR NOVEL IN VIVO MOLECULAR PROBES FOR ATTENUATION OF SYNAPTIC DYSFUNCTION AND PROINFLAMMATORY CYTOKINE OVERPRODUCTION Alzheimer's & Dementia. 13: P951-P952. DOI: 10.1016/J.Jalz.2017.06.1265  0.373
2016 Koppensteiner P, Trinchese F, Fà M, Puzzo D, Gulisano W, Yan S, Poussin A, Liu S, Orozco I, Dale E, Teich AF, Palmeri A, Ninan I, Boehm S, Arancio O. Time-dependent reversal of synaptic plasticity induced by physiological concentrations of oligomeric Aβ42: an early index of Alzheimer's disease. Scientific Reports. 6: 32553. PMID 27581852 DOI: 10.1038/Srep32553  0.796
2016 Brullo C, Ricciarelli R, Prickaerts J, Arancio O, Massa M, Rotolo C, Romussi A, Rebosio C, Marengo B, Pronzato MA, van Hagen BT, van Goethem NP, D'Ursi P, Orro A, Milanesi L, et al. New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment. European Journal of Medicinal Chemistry. 124: 82-102. PMID 27560284 DOI: 10.1016/J.Ejmech.2016.08.018  0.411
2016 Manassero G, Guglielmotto M, Zamfir R, Borghi R, Colombo L, Salmona M, Perry G, Odetti P, Arancio O, Tamagno E, Tabaton M. Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein. Aging Cell. PMID 27406053 DOI: 10.1111/Acel.12500  0.429
2016 Luo J, Lee SH, VandeVrede L, Qin Z, Aissa MB, Larson J, Teich AF, Arancio O, D'Souza Y, Elharram A, Koster K, Tai LM, LaDu MJ, Bennett BM, Thatcher GR. Erratum to: A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer's disease. Molecular Neurodegeneration. 11: 40. PMID 27194246 DOI: 10.1186/S13024-016-0104-5  0.311
2016 Luo J, Lee SH, VandeVrede L, Qin Z, Ben Aissa M, Larson J, Teich AF, Arancio O, D'Souza Y, Elharram A, Koster K, Tai LM, LaDu MJ, Bennett BM, Thatcher GR. A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer's disease. Molecular Neurodegeneration. 11: 35. PMID 27129593 DOI: 10.1186/S13024-016-0103-6  0.419
2016 Teich AF, Sakurai M, Patel M, Holman C, Saeed F, Fiorito J, Arancio O. PDE5 Exists in Human Neurons and is a Viable Therapeutic Target for Neurologic Disease. Journal of Alzheimer's Disease : Jad. PMID 26967220 DOI: 10.3233/Jad-151104  0.313
2016 Nicholls RE, Sontag JM, Zhang H, Staniszewski A, Yan S, Kim CY, Yim M, Woodruff CM, Arning E, Wasek B, Yin D, Bottiglieri T, Sontag E, Kandel ER, Arancio O. PP2A methylation controls sensitivity and resistance to β-amyloid-induced cognitive and electrophysiological impairments. Proceedings of the National Academy of Sciences of the United States of America. PMID 26951658 DOI: 10.1073/Pnas.1521018113  0.57
2016 Fá M, Puzzo D, Piacentini R, Staniszewski A, Zhang H, Baltrons MA, Li Puma DD, Chatterjee I, Li J, Saeed F, Berman HL, Ripoli C, Gulisano W, Gonzalez J, Tian H, ... ... Arancio O, et al. Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory. Scientific Reports. 6: 19393. PMID 26786552 DOI: 10.1038/Srep19393  0.456
2016 Ben Aissa M, Lee SH, Luo J, Arancio O, LaDu MJ, Bennett BM, Pepperberg DR, Thatcher GR. P1-035: NO/CGMP/CREB-Based Synaptic Repair as a Multifunctional Therapeutic Approach to Disease Modification in Multiple Familial Mouse Models and a Novel Sporadic Model Of Alzheimer's Disease Alzheimer's & Dementia. 12: P414-P414. DOI: 10.1016/J.Jalz.2016.06.782  0.391
2015 Fà M, Zhang H, Staniszewski A, Saeed F, Shen LW, Schiefer IT, Siklos MI, Tapadar S, Litosh VA, Libien J, Petukhov PA, Teich AF, Thatcher GR, Arancio O. Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 26484927 DOI: 10.3233/Jad-150618  0.408
2015 Luo J, Lee SH, VandeVrede L, Qin Z, Piyankarage S, Tavassoli E, Asghodom RT, Aissa MB, Fà M, Arancio O, Yue L, Pepperberg DR, Thatcher GR. Re-engineering a neuroprotective, clinical drug as a procognitive agent with high in vivo potency and with GABAA potentiating activity for use in dementia. Bmc Neuroscience. 16: 67. PMID 26480871 DOI: 10.1186/S12868-015-0208-9  0.48
2015 Puzzo D, Gulisano W, Arancio O, Palmeri A. The keystone of Alzheimer pathogenesis might be sought in Aβ physiology. Neuroscience. 307: 26-36. PMID 26314631 DOI: 10.1016/J.Neuroscience.2015.08.039  0.503
2015 Lee L, Dale E, Staniszewski A, Zhang H, Saeed F, Sakurai M, Fa' M, Orozco I, Michelassi F, Akpan N, Lehrer H, Arancio O. Corrigendum: Regulation of synaptic plasticity and cognition by SUMO in normal physiology and Alzheimer's disease. Scientific Reports. 5: 11782. PMID 26149080 DOI: 10.1038/Srep11782  0.785
2015 Fang D, Wang Y, Zhang Z, Du H, Yan S, Sun Q, Zhong C, Wu L, Vangavaragu JR, Yan S, Hu G, Guo L, Rabinowitz M, Glaser E, Arancio O, et al. Increased neuronal PreP activity reduces Aβ accumulation, attenuates neuroinflammation, and improves mitochondrial and synaptic function in Alzheimer disease's mouse model. Human Molecular Genetics. PMID 26123488 DOI: 10.1093/Hmg/Ddv241  0.473
2015 Chinchalongporn V, Koppensteiner P, Prè D, Thangnipon W, Bilo L, Arancio O. Connectivity and circuitry in a dish versus in a brain. Alzheimer's Research & Therapy. 7: 44. PMID 26045718 DOI: 10.1186/S13195-015-0129-Y  0.339
2015 Matsuzaki S, Lee L, Knock E, Srikumar T, Sakurai M, Hazrati LN, Katayama T, Staniszewski A, Raught B, Arancio O, Fraser PE. SUMO1 Affects Synaptic Function, Spine Density and Memory. Scientific Reports. 5: 10730. PMID 26022678 DOI: 10.1038/Srep10730  0.61
2015 Puzzo D, Gulisano W, Palmeri A, Arancio O. Rodent models for Alzheimer's disease drug discovery. Expert Opinion On Drug Discovery. 10: 703-11. PMID 25927677 DOI: 10.1517/17460441.2015.1041913  0.416
2015 Kim S, Titcombe RF, Zhang H, Khatri L, Girma HK, Hofmann F, Arancio O, Ziff EB. Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca2+-permeable AMPA receptors. Proceedings of the National Academy of Sciences of the United States of America. 112: 3122-7. PMID 25713349 DOI: 10.1073/Pnas.1417498112  0.417
2015 Roy SM, Grum-Tokars VL, Schavocky JP, Saeed F, Staniszewski A, Teich AF, Arancio O, Bachstetter AD, Webster SJ, Van Eldik LJ, Minasov G, Anderson WF, Pelletier JC, Watterson DM. Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models. Acs Chemical Neuroscience. 6: 666-80. PMID 25676389 DOI: 10.1021/Acschemneuro.5B00002  0.358
2015 Teich AF, Nicholls RE, Puzzo D, Fiorito J, Purgatorio R, Fa' M, Arancio O. Synaptic therapy in Alzheimer's disease: a CREB-centric approach. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 12: 29-41. PMID 25575647 DOI: 10.1007/S13311-014-0327-5  0.487
2015 Van Eldik LJ, Roy SM, Watterson DM, Arancio O. P1-304: An optimized and isoform-selective p38aMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models Alzheimer's & Dementia. 11: P473-P473. DOI: 10.1016/J.Jalz.2015.06.519  0.324
2014 Lee L, Dale E, Staniszewski A, Zhang H, Saeed F, Sakurai M, Fa' M, Orozco I, Michelassi F, Akpan N, Lehrer H, Arancio O. Regulation of synaptic plasticity and cognition by SUMO in normal physiology and Alzheimer's disease. Scientific Reports. 4: 7190. PMID 25448527 DOI: 10.1038/Srep07190  0.816
2014 Koppensteiner P, Boehm S, Arancio O. Electrophysiological profiles of induced neurons converted directly from adult human fibroblasts indicate incomplete neuronal conversion. Cellular Reprogramming. 16: 439-46. PMID 25437871 DOI: 10.1089/Cell.2014.0054  0.301
2014 Izzo NJ, Xu J, Zeng C, Kirk MJ, Mozzoni K, Silky C, Rehak C, Yurko R, Look G, Rishton G, Safferstein H, Cruchaga C, Goate A, Cahill MA, Arancio O, et al. Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity. Plos One. 9: e111899. PMID 25390692 DOI: 10.1371/Journal.Pone.0111899  0.491
2014 Izzo NJ, Staniszewski A, To L, Fa M, Teich AF, Saeed F, Wostein H, Walko T, Vaswani A, Wardius M, Syed Z, Ravenscroft J, Mozzoni K, Silky C, Rehak C, ... ... Arancio O, et al. Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits. Plos One. 9: e111898. PMID 25390368 DOI: 10.1371/Journal.Pone.0111898  0.473
2014 Yan S, Li Z, Li H, Arancio O, Zhang W. Notoginsenoside R1 increases neuronal excitability and ameliorates synaptic and memory dysfunction following amyloid elevation. Scientific Reports. 4: 6352. PMID 25213453 DOI: 10.1038/Srep06352  0.514
2014 Tang G, Gudsnuk K, Kuo SH, Cotrina ML, Rosoklija G, Sosunov A, Sonders MS, Kanter E, Castagna C, Yamamoto A, Yue Z, Arancio O, Peterson BS, Champagne F, Dwork AJ, et al. Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits. Neuron. 83: 1131-43. PMID 25155956 DOI: 10.1016/J.Neuron.2014.07.040  0.395
2014 Guglielmotto M, Monteleone D, Piras A, Valsecchi V, Tropiano M, Ariano S, Fornaro M, Vercelli A, Puyal J, Arancio O, Tabaton M, Tamagno E. Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosis. Autophagy. 10: 1827-43. PMID 25136804 DOI: 10.4161/Auto.30001  0.366
2014 Prè D, Nestor MW, Sproul AA, Jacob S, Koppensteiner P, Chinchalongporn V, Zimmer M, Yamamoto A, Noggle SA, Arancio O. A time course analysis of the electrophysiological properties of neurons differentiated from human induced pluripotent stem cells (iPSCs). Plos One. 9: e103418. PMID 25072157 DOI: 10.1371/Journal.Pone.0103418  0.331
2014 Origlia N, Criscuolo C, Arancio O, Yan SS, Domenici L. RAGE inhibition in microglia prevents ischemia-dependent synaptic dysfunction in an amyloid-enriched environment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 8749-60. PMID 24966375 DOI: 10.1523/Jneurosci.0141-14.2014  0.512
2014 Fà M, Staniszewski A, Saeed F, Francis YI, Arancio O. Dynamin 1 is required for memory formation. Plos One. 9: e91954. PMID 24643165 DOI: 10.1371/Journal.Pone.0091954  0.423
2014 Ricciarelli R, Puzzo D, Bruno O, Canepa E, Gardella E, Rivera D, Privitera L, Domenicotti C, Marengo B, Marinari UM, Palmeri A, Pronzato MA, Arancio O, Fedele E. A novel mechanism for cyclic adenosine monophosphate-mediated memory formation: Role of amyloid beta. Annals of Neurology. 75: 602-7. PMID 24591104 DOI: 10.1002/Ana.24130  0.461
2014 Puzzo D, Lee L, Palmeri A, Calabrese G, Arancio O. Behavioral assays with mouse models of Alzheimer's disease: practical considerations and guidelines. Biochemical Pharmacology. 88: 450-67. PMID 24462904 DOI: 10.1016/J.Bcp.2014.01.011  0.577
2014 Sproul AA, Jacob S, Pre D, Kim SH, Nestor MW, Navarro-Sobrino M, Santa-Maria I, Zimmer M, Aubry S, Steele JW, Kahler DJ, Dranovsky A, Arancio O, Crary JF, Gandy S, et al. Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors. Plos One. 9: e84547. PMID 24416243 DOI: 10.1371/Journal.Pone.0084547  0.335
2014 Orozco IJ, Koppensteiner P, Ninan I, Arancio O. The schizophrenia susceptibility gene DTNBP1 modulates AMPAR synaptic transmission and plasticity in the hippocampus of juvenile DBA/2J mice. Molecular and Cellular Neurosciences. 58: 76-84. PMID 24321452 DOI: 10.1016/J.Mcn.2013.12.003  0.763
2014 Puzzo D, Loreto C, Giunta S, Musumeci G, Frasca G, Podda MV, Arancio O, Palmeri A. Effect of phosphodiesterase-5 inhibition on apoptosis and beta amyloid load in aged mice. Neurobiology of Aging. 35: 520-31. PMID 24112792 DOI: 10.1016/J.Neurobiolaging.2013.09.002  0.437
2014 Lee L, Kosuri P, Arancio O. Picomolar amyloid-β peptides enhance spontaneous astrocyte calcium transients. Journal of Alzheimer's Disease : Jad. 38: 49-62. PMID 23948929 DOI: 10.3233/Jad-130740  0.591
2014 Tang G, Gudsnuk K, Kuo SH, Cotrina ML, Rosoklija G, Sosunov A, Sonders MS, Kanter E, Castagna C, Yamamoto A, Yue Z, Arancio O, Peterson BS, Champagne F, Dwork AJ, et al. Erratam to Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits[Neuron, 83, (2014), 1131-1143] Neuron. 83: 1482. DOI: 10.1016/j.neuron.2014.09.001  0.319
2014 Fedele E, Puzzo D, Bruno O, Canepa E, Gardella E, Rivera D, Privitera L, Domenicotti C, Marengo B, Marinari U, Palmeri A, Pronzato M, Arancio O, Ricciarelli R. A Physiological Role For Amyloid Beta In Cyclic Amp-Stimulated Long Term Potentiation Alzheimers & Dementia. 10: 328. DOI: 10.1016/J.Jalz.2014.05.304  0.333
2013 Lee L, Sakurai M, Matsuzaki S, Arancio O, Fraser P. SUMO and Alzheimer's disease. Neuromolecular Medicine. 15: 720-36. PMID 23979993 DOI: 10.1007/S12017-013-8257-7  0.601
2013 Watterson DM, Grum-Tokars VL, Roy SM, Schavocky JP, Bradaric BD, Bachstetter AD, Xing B, Dimayuga E, Saeed F, Zhang H, Staniszewski A, Pelletier JC, Minasov G, Anderson WF, Arancio O, et al. Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction. Plos One. 8: e66226. PMID 23840427 DOI: 10.1371/Journal.Pone.0066226  0.391
2013 Schiefer IT, Tapadar S, Litosh V, Siklos M, Scism R, Wijewickrama GT, Chandrasena EP, Sinha V, Tavassoli E, Brunsteiner M, Fa' M, Arancio O, Petukhov P, Thatcher GR. Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors. Journal of Medicinal Chemistry. 56: 6054-68. PMID 23834438 DOI: 10.1021/Jm4006719  0.304
2013 Pozueta J, Lefort R, Ribe EM, Troy CM, Arancio O, Shelanski M. Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice. Nature Communications. 4: 1939. PMID 23748737 DOI: 10.1038/Ncomms2927  0.442
2013 Knowles JK, Simmons DA, Nguyen TV, Vander Griend L, Xie Y, Zhang H, Yang T, Pollak J, Chang T, Arancio O, Buckwalter MS, Wyss-Coray T, Massa SM, Longo FM. Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model. Neurobiology of Aging. 34: 2052-63. PMID 23545424 DOI: 10.1016/J.Neurobiolaging.2013.02.015  0.427
2013 Lombino F, Biundo F, Tamayev R, Arancio O, D'Adamio L. An intracellular threonine of amyloid-β precursor protein mediates synaptic plasticity deficits and memory loss. Plos One. 8: e57120. PMID 23451158 DOI: 10.1371/Journal.Pone.0057120  0.491
2013 Teich AF, Patel M, Arancio O. A reliable way to detect endogenous murine β-amyloid. Plos One. 8: e55647. PMID 23383341 DOI: 10.1371/Journal.Pone.0055647  0.35
2013 Fiorito J, Saeed F, Zhang H, Staniszewski A, Feng Y, Francis YI, Rao S, Thakkar DM, Deng SX, Landry DW, Arancio O. Synthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease. European Journal of Medicinal Chemistry. 60: 285-94. PMID 23313637 DOI: 10.1016/J.Ejmech.2012.12.009  0.41
2013 Xing L, Salas M, Zhang H, Gittler J, Ludwig T, Lin CS, Murty VV, Silverman W, Arancio O, Tycko B. Creation and characterization of BAC-transgenic mice with physiological overexpression of epitope-tagged RCAN1 (DSCR1). Mammalian Genome : Official Journal of the International Mammalian Genome Society. 24: 30-43. PMID 23096997 DOI: 10.1007/S00335-012-9436-9  0.35
2013 Puzzo D, Arancio O. Amyloid-β peptide: Dr. Jekyll or Mr. Hyde? Journal of Alzheimer's Disease : Jad. 33: S111-20. PMID 22735675 DOI: 10.3233/Jad-2012-129033  0.503
2013 Watterson DM, Pelletier J, Anderson W, Arancio O, Van Eldik L. P4-313: Revisiting protein kinases as CNS targets: Attenuation of synaptic dysfunction Alzheimer's & Dementia. 9: P818-P819. DOI: 10.1016/J.Jalz.2013.05.1758  0.37
2013 Longo F, Nguyen T, Simmons D, Yang T, Knowles J, Zhang H, Arancio O, Massa S, Longo F. S4-02-04: Targeting Alzheimer's disease-related mechanisms with p75 ligands Alzheimer's & Dementia. 9: P674-P674. DOI: 10.1016/J.Jalz.2013.04.323  0.302
2013 Ren H, Orozco I, Su Y, Suyama S, Gutiérrez-Juárez R, Horvath T, Wardlaw S, Plum L, Arancio O, Accili D. FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake Cell. 153: 1166. DOI: 10.1016/J.Cell.2013.05.010  0.707
2012 Tamayev R, Akpan N, Arancio O, Troy CM, D'Adamio L. Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection. Molecular Neurodegeneration. 7: 60. PMID 23217200 DOI: 10.1186/1750-1326-7-60  0.447
2012 McIntire LB, Berman DE, Myaeng J, Staniszewski A, Arancio O, Di Paolo G, Kim TW. Reduction of synaptojanin 1 ameliorates synaptic and behavioral impairments in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15271-6. PMID 23115165 DOI: 10.1523/Jneurosci.2034-12.2012  0.534
2012 Liu X, Betzenhauser MJ, Reiken S, Meli AC, Xie W, Chen BX, Arancio O, Marks AR. Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction. Cell. 150: 1055-67. PMID 22939628 DOI: 10.1016/J.Cell.2012.06.052  0.368
2012 Teich AF, Arancio O. Is the amyloid hypothesis of Alzheimer's disease therapeutically relevant? The Biochemical Journal. 446: 165-77. PMID 22891628 DOI: 10.1042/Bj20120653  0.399
2012 Hashimoto G, Sakurai M, Teich AF, Saeed F, Aziz F, Arancio O. 5-HTâ‚„ receptor stimulation leads to soluble AβPPα production through MMP-9 upregulation. Journal of Alzheimer's Disease : Jad. 32: 437-45. PMID 22810092 DOI: 10.3233/Jad-2012-111235  0.31
2012 Qin Z, Luo J, VandeVrede L, Tavassoli E, Fa' M, Teich AF, Arancio O, Thatcher GR. Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy. Journal of Medicinal Chemistry. 55: 6784-801. PMID 22779770 DOI: 10.1021/Jm300353R  0.499
2012 Ren H, Orozco IJ, Su Y, Suyama S, Gutiérrez-Juárez R, Horvath TL, Wardlaw SL, Plum L, Arancio O, Accili D. FoxO1 target Gpr17 activates AgRP neurons to regulate food intake. Cell. 149: 1314-26. PMID 22682251 DOI: 10.1016/j.cell.2012.04.032  0.708
2012 Gaisler-Salomon I, Wang Y, Chuhma N, Zhang H, Golumbic YN, Mihali A, Arancio O, Sibille E, Rayport S. Synaptic underpinnings of altered hippocampal function in glutaminase-deficient mice during maturation. Hippocampus. 22: 1027-39. PMID 22431402 DOI: 10.1002/Hipo.22014  0.388
2012 Schiefer IT, VandeVrede L, Fa' M, Arancio O, Thatcher GR. Furoxans (1,2,5-oxadiazole-N-oxides) as novel NO mimetic neuroprotective and procognitive agents. Journal of Medicinal Chemistry. 55: 3076-87. PMID 22429006 DOI: 10.1021/Jm201504S  0.409
2012 Tamayev R, Matsuda S, Arancio O, D'Adamio L. β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia. Embo Molecular Medicine. 4: 171-9. PMID 22170863 DOI: 10.1002/Emmm.201100195  0.441
2012 Origlia N, Criscuolo C, Arancio O, ShiDu Yan S, Domenici L. P4-037: Ischemia as a trigger for RAGE-dependent synaptic dysfunction in an amyloid-enriched environment Alzheimer's & Dementia. 8: P649-P649. DOI: 10.1016/J.Jalz.2012.05.1738  0.448
2011 Tamayev R, Matsuda S, Giliberto L, Arancio O, D'Adamio L. APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant. The Embo Journal. 30: 2501-9. PMID 21587206 DOI: 10.1038/Emboj.2011.161  0.476
2011 Puzzo D, Privitera L, Fa' M, Staniszewski A, Hashimoto G, Aziz F, Sakurai M, Ribe EM, Troy CM, Mercken M, Jung SS, Palmeri A, Arancio O. Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory. Annals of Neurology. 69: 819-30. PMID 21472769 DOI: 10.1002/Ana.22313  0.435
2011 Duffy AM, Schaner MJ, Wu SH, Staniszewski A, Kumar A, Arévalo JC, Arancio O, Chao MV, Scharfman HE. A selective role for ARMS/Kidins220 scaffold protein in spatial memory and trophic support of entorhinal and frontal cortical neurons. Experimental Neurology. 229: 409-20. PMID 21419124 DOI: 10.1016/J.Expneurol.2011.03.008  0.328
2011 Yao J, Du H, Yan S, Fang F, Wang C, Lue LF, Guo L, Chen D, Stern DM, Gunn Moore FJ, Xi Chen J, Arancio O, Yan SS. Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 2313-20. PMID 21307267 DOI: 10.1523/Jneurosci.4717-10.2011  0.411
2011 Puzzo D, Arancio O, Privitera L, Palmeri A, Furnari D. P1-014: Hormetic effect of amyloid-beta peptide on synaptic plasticity and memory Alzheimer's & Dementia. 7: S116-S116. DOI: 10.1016/J.Jalz.2011.05.293  0.429
2011 Fa M, Koppensteiner P, Trinchese F, Liu S, Ninan I, Arancio O. P3-219: Picomolar Beta-Amyloid progressively impairs synaptic plasticity over time while simultaneously increases spontaneous neurotransmission Alzheimer's & Dementia. 7: S586-S586. DOI: 10.1016/J.Jalz.2011.05.1660  0.45
2011 Origlia N, Arancio O, Du Yan S, Domenici L. P2-255: Microglial RAGE-dependent signal pathway contributes to synaptic dysfunction induced by amyloid and transient ischemia in entorhinal cortex Alzheimer's & Dementia. 7: S393-S393. DOI: 10.1016/J.Jalz.2011.05.1136  0.408
2010 Oliveira TG, Chan RB, Tian H, Laredo M, Shui G, Staniszewski A, Zhang H, Wang L, Kim TW, Duff KE, Wenk MR, Arancio O, Di Paolo G. Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 16419-28. PMID 21147981 DOI: 10.1523/Jneurosci.3317-10.2010  0.458
2010 Tamayev R, Matsuda S, Fà M, Arancio O, D'Adamio L. Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits. Proceedings of the National Academy of Sciences of the United States of America. 107: 20822-7. PMID 21098268 DOI: 10.1073/Pnas.1011689107  0.454
2010 Tamayev R, Giliberto L, Li W, d'Abramo C, Arancio O, Vidal R, D'Adamio L. Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 14915-24. PMID 21048150 DOI: 10.1523/Jneurosci.3917-10.2010  0.352
2010 Wu SH, Arévalo JC, Neubrand VE, Zhang H, Arancio O, Chao MV. The ankyrin repeat-rich membrane spanning (ARMS)/Kidins220 scaffold protein is regulated by activity-dependent calpain proteolysis and modulates synaptic plasticity. The Journal of Biological Chemistry. 285: 40472-8. PMID 20943655 DOI: 10.1074/Jbc.M110.171371  0.463
2010 Origlia N, Bonadonna C, Rosellini A, Leznik E, Arancio O, Yan SS, Domenici L. Microglial receptor for advanced glycation end product-dependent signal pathway drives beta-amyloid-induced synaptic depression and long-term depression impairment in entorhinal cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11414-25. PMID 20739563 DOI: 10.1523/Jneurosci.2127-10.2010  0.474
2010 Fa M, Orozco IJ, Francis YI, Saeed F, Gong Y, Arancio O. Preparation of oligomeric beta-amyloid 1-42 and induction of synaptic plasticity impairment on hippocampal slices. Journal of Visualized Experiments : Jove. PMID 20644518 DOI: 10.3791/1884  0.772
2010 Arévalo JC, Wu SH, Takahashi T, Zhang H, Yu T, Yano H, Milner TA, Tessarollo L, Ninan I, Arancio O, Chao MV. The ARMS/Kidins220 scaffold protein modulates synaptic transmission. Molecular and Cellular Neurosciences. 45: 92-100. PMID 20547223 DOI: 10.1016/J.Mcn.2010.06.002  0.429
2010 Lee L, Dale E, Staniszewski A, Zhang H, Michelassi F, Sakurai M, Kapadia C, Arancio O. P4-030: Elevated Amyloid-beta Impairs Protein Sumoylation Alzheimer's & Dementia. 6: e29-e29. DOI: 10.1016/J.Jalz.2010.08.090  0.533
2010 McIntire LBJ, Berman D, Myaeng J, Staniszewski A, Arancio O, Paolo GD, Kim T. Hemizygous deletion of synaptojanin1 ameliorates learning and memory impairments in a mouse model of Alzheimer's disease Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.08.024  0.367
2010 Moe JG, Chatterjee I, Puzzo D, Agnieszka S, Fa M, Davidowitz EJ, Arancio O. P1-361: Extracellular oligomeric tau inhibits memory formation in mice Alzheimer's & Dementia. 6: S277-S277. DOI: 10.1016/J.Jalz.2010.05.915  0.338
2010 Oliveira TG, Chan RB, Tian H, Staniszewski A, Zhang H, Wang L, Kim T, Duff KE, Wenk MR, Arancio O, Paolo GD. Phospholipase D2 ablation ameliorates Alzheimer-linked synaptic dysfunction and cognitive deficits: Mechanistic insights from lipidomic analysis Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.1389  0.41
2010 Fa M, Leznik E, Ninan I, Trinchese F, Liu S, Orozco IJ, Koppensteiner P, Arancio O. P2-333: Enhanced spontaneous release of neurotransmitter underlies early changes in synaptic function by beta-amyloid Alzheimer's & Dementia. 6: S411-S411. DOI: 10.1016/J.Jalz.2010.05.1384  0.758
2009 Origlia N, Arancio O, Domenici L, Yan SS. MAPK, beta-amyloid and synaptic dysfunction: the role of RAGE. Expert Review of Neurotherapeutics. 9: 1635-45. PMID 19903023 DOI: 10.1586/Ern.09.107  0.493
2009 Smith DL, Pozueta J, Gong B, Arancio O, Shelanski M. Reversal of long-term dendritic spine alterations in Alzheimer disease models. Proceedings of the National Academy of Sciences of the United States of America. 106: 16877-82. PMID 19805389 DOI: 10.1073/Pnas.0908706106  0.469
2009 Francis YI, Fà M, Ashraf H, Zhang H, Staniszewski A, Latchman DS, Arancio O. Dysregulation of histone acetylation in the APP/PS1 mouse model of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 18: 131-9. PMID 19625751 DOI: 10.3233/Jad-2009-1134  0.401
2009 Puzzo D, Staniszewski A, Deng SX, Privitera L, Leznik E, Liu S, Zhang H, Feng Y, Palmeri A, Landry DW, Arancio O. Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 8075-86. PMID 19553447 DOI: 10.1523/Jneurosci.0864-09.2009  0.484
2009 Gaisler-Salomon I, Miller GM, Chuhma N, Lee S, Zhang H, Ghoddoussi F, Lewandowski N, Fairhurst S, Wang Y, Conjard-Duplany A, Masson J, Balsam P, Hen R, Arancio O, Galloway MP, et al. Glutaminase-deficient mice display hippocampal hypoactivity, insensitivity to pro-psychotic drugs and potentiated latent inhibition: relevance to schizophrenia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 2305-22. PMID 19516252 DOI: 10.1038/Npp.2009.58  0.36
2009 Basavarajappa BS, Nixon RA, Arancio O. Endocannabinoid system: emerging role from neurodevelopment to neurodegeneration. Mini Reviews in Medicinal Chemistry. 9: 448-62. PMID 19356123 DOI: 10.2174/138955709787847921  0.322
2009 Origlia N, Capsoni S, Cattaneo A, Fang F, Arancio O, Yan SD, Domenici L. Abeta-dependent Inhibition of LTP in different intracortical circuits of the visual cortex: the role of RAGE. Journal of Alzheimer's Disease : Jad. 17: 59-68. PMID 19221410 DOI: 10.3233/Jad-2009-1045  0.414
2009 Vitolo O, Gong B, Cao Z, Ishii H, Jaracz S, Nakanishi K, Arancio O, Dzyuba SV, Lefort R, Shelanski M. Protection against beta-amyloid induced abnormal synaptic function and cell death by Ginkgolide J. Neurobiology of Aging. 30: 257-65. PMID 17640772 DOI: 10.1016/J.Neurobiolaging.2007.05.025  0.41
2009 Arancio O. Amyloid-beta: From physiology to pathology Neuroscience Research. 65: S4. DOI: 10.1016/J.Neures.2009.09.1484  0.326
2009 Puzzo D, Privitera L, Leznik E, Fa’ M, Staniszewsky A, Hashimoto G, Aziz F, Sakurai M, Ribe EM, Mathews PM, Troy CM, Mercken M, Jung SS, Palmeri A, Arancio O. O4-03-05: Amyloid-beta peptide is required for synaptic plasticity and memory Alzheimer's & Dementia. 5: P155-P155. DOI: 10.1016/J.Jalz.2009.05.535  0.413
2009 Moe JG, Chatterjee I, Davidowitz EJ, Arancio O. P4-236: Modulation of synaptic function by extracellular tau enriched in oligomers Alzheimer's & Dementia. 5: P499-P499. DOI: 10.1016/J.Jalz.2009.04.702  0.417
2009 Domenici L, Origlia N, Capsoni S, Cattaneo A, Fang F, Arancio O, Yan SD. P4-234: Aβ-dependent inhibition of LTP in different intra-cortical circuits of the visual cortex is mediated by RAGE Alzheimer's & Dementia. 5: P499-P499. DOI: 10.1016/J.Jalz.2009.04.700  0.312
2009 Origlia N, Arancio O, Yan SD, Domenici L. P4-231: Neuronal and microglial RAGE-dependent signal pathways involved in Aβ-induced synaptic dysfunction in entorhinal cortex Alzheimer's & Dementia. 5: P498-P498. DOI: 10.1016/J.Jalz.2009.04.697  0.437
2009 Bonadonna C, Origlia N, Rosellini A, Arancio O, Yan S, Domenici L. P4-221: BDNF prevents activation of stress related kinases by Aβ in cortical neurons Alzheimer's & Dementia. 5: P495-P495. DOI: 10.1016/J.Jalz.2009.04.687  0.339
2008 Puzzo D, Privitera L, Leznik E, Fà M, Staniszewski A, Palmeri A, Arancio O. Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 14537-45. PMID 19118188 DOI: 10.1523/Jneurosci.2692-08.2008  0.476
2008 Yang T, Knowles JK, Lu Q, Zhang H, Arancio O, Moore LA, Chang T, Wang Q, Andreasson K, Rajadas J, Fuller GG, Xie Y, Massa SM, Longo FM. Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment. Plos One. 3: e3604. PMID 18978948 DOI: 10.1371/Journal.Pone.0003604  0.449
2008 Du H, Guo L, Fang F, Chen D, Sosunov AA, McKhann GM, Yan Y, Wang C, Zhang H, Molkentin JD, Gunn-Moore FJ, Vonsattel JP, Arancio O, Chen JX, Yan SD. Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease. Nature Medicine. 14: 1097-105. PMID 18806802 DOI: 10.1038/Nm.1868  0.432
2008 Basavarajappa BS, Ninan I, Arancio O. Acute ethanol suppresses glutamatergic neurotransmission through endocannabinoids in hippocampal neurons. Journal of Neurochemistry. 107: 1001-13. PMID 18796007 DOI: 10.1111/J.1471-4159.2008.05685.X  0.316
2008 Puzzo D, Sapienza S, Arancio O, Palmeri A. Role of phosphodiesterase 5 in synaptic plasticity and memory. Neuropsychiatric Disease and Treatment. 4: 371-87. PMID 18728748 DOI: 10.2147/Ndt.S2447  0.382
2008 Serulle Y, Arancio O, Ziff EB. A role for cGMP-dependent protein kinase II in AMPA receptor trafficking and synaptic plasticity. Channels (Austin, Tex.). 2: 230-2. PMID 18728399 DOI: 10.1016/J.Neures.2009.09.1657  0.379
2008 Trinchese F, Fa' M, Liu S, Zhang H, Hidalgo A, Schmidt SD, Yamaguchi H, Yoshii N, Mathews PM, Nixon RA, Arancio O. Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. The Journal of Clinical Investigation. 118: 2796-807. PMID 18596919 DOI: 10.1172/Jci34254  0.483
2008 Voronov SV, Frere SG, Giovedi S, Pollina EA, Borel C, Zhang H, Schmidt C, Akeson EC, Wenk MR, Cimasoni L, Arancio O, Davisson MT, Antonarakis SE, Gardiner K, De Camilli P, et al. Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome. Proceedings of the National Academy of Sciences of the United States of America. 105: 9415-20. PMID 18591654 DOI: 10.1073/Pnas.0803756105  0.337
2008 Liu L, Orozco IJ, Planel E, Wen Y, Bretteville A, Krishnamurthy P, Wang L, Herman M, Figueroa H, Yu WH, Arancio O, Duff K. A transgenic rat that develops Alzheimer's disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment. Neurobiology of Disease. 31: 46-57. PMID 18504134 DOI: 10.1016/J.Nbd.2008.03.005  0.764
2008 Muhammad A, Flores I, Zhang H, Yu R, Staniszewski A, Planel E, Herman M, Ho L, Kreber R, Honig LS, Ganetzky B, Duff K, Arancio O, Small SA. Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation. Proceedings of the National Academy of Sciences of the United States of America. 105: 7327-32. PMID 18480253 DOI: 10.1073/Pnas.0802545105  0.46
2008 Berman DE, Dall'Armi C, Voronov SV, McIntire LB, Zhang H, Moore AZ, Staniszewski A, Arancio O, Kim TW, Di Paolo G. Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism. Nature Neuroscience. 11: 547-54. PMID 18391946 DOI: 10.1038/Nn.2100  0.488
2008 Origlia N, Righi M, Capsoni S, Cattaneo A, Fang F, Stern DM, Chen JX, Schmidt AM, Arancio O, Yan SD, Domenici L. Receptor for advanced glycation end product-dependent activation of p38 mitogen-activated protein kinase contributes to amyloid-beta-mediated cortical synaptic dysfunction. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 3521-30. PMID 18367618 DOI: 10.1523/Jneurosci.0204-08.2008  0.512
2008 Matsuoka Y, Jouroukhin Y, Gray AJ, Ma L, Hirata-Fukae C, Li HF, Feng L, Lecanu L, Walker BR, Planel E, Arancio O, Gozes I, Aisen PS. A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease. The Journal of Pharmacology and Experimental Therapeutics. 325: 146-53. PMID 18199809 DOI: 10.1124/Jpet.107.130526  0.397
2008 Arancio O, Puzzo D, Privitera L, Leznik E, Fa M, Staniszewski A, Palmeri A. O4-06-03: Amyloid-beta peptide is a positive modulator of synaptic plasticity and memory Alzheimer's & Dementia. 4: T196-T197. DOI: 10.1016/J.Jalz.2008.05.547  0.404
2008 Small S, Duff K, Arancio O, Ganetzky B, Honig L. O3-01-03: Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.407  0.376
2008 Arancio O. S2-02-04: Amyloid-beta: From physiology to pathology Alzheimer's & Dementia. 4: T125-T125. DOI: 10.1016/J.Jalz.2008.05.279  0.332
2008 Leznik E, Trinchese F, Ninan I, Liu S, Arancio O. P3-393: Prolonged exposure to amyloid-β at physiologically relevant levels enhances basal synaptic transmission, but blocks plasticity in the hippocampus Alzheimer's & Dementia. 4: T636-T637. DOI: 10.1016/J.Jalz.2008.05.1963  0.417
2007 Chen X, Walker DG, Schmidt AM, Arancio O, Lue LF, Yan SD. RAGE: a potential target for Abeta-mediated cellular perturbation in Alzheimer's disease. Current Molecular Medicine. 7: 735-42. PMID 18331231 DOI: 10.2174/156652407783220741  0.439
2007 Echeverria V, Berman DE, Arancio O. Oligomers of beta-amyloid peptide inhibit BDNF-induced arc expression in cultured cortical Neurons. Current Alzheimer Research. 4: 518-21. PMID 18220514 DOI: 10.2174/156720507783018190  0.54
2007 Serulle Y, Zhang S, Ninan I, Puzzo D, McCarthy M, Khatri L, Arancio O, Ziff EB. A GluR1-cGKII interaction regulates AMPA receptor trafficking. Neuron. 56: 670-88. PMID 18031684 DOI: 10.1016/J.Neuron.2007.09.016  0.349
2007 Liu S, Fa M, Ninan I, Trinchese F, Dauer W, Arancio O. Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII. The European Journal of Neuroscience. 25: 3583-96. PMID 17610578 DOI: 10.1111/J.1460-9568.2007.05569.X  0.358
2007 Arancio O, Chao MV. Neurotrophins, synaptic plasticity and dementia. Current Opinion in Neurobiology. 17: 325-30. PMID 17419049 DOI: 10.1016/J.Conb.2007.03.013  0.496
2006 Puzzo D, Palmeri A, Arancio O. Involvement of the nitric oxide pathway in synaptic dysfunction following amyloid elevation in Alzheimer's disease. Reviews in the Neurosciences. 17: 497-523. PMID 17180876 DOI: 10.1515/Revneuro.2006.17.5.497  0.523
2006 Ninan I, Liu S, Rabinowitz D, Arancio O. Early presynaptic changes during plasticity in cultured hippocampal neurons. The Embo Journal. 25: 4361-71. PMID 16957772 DOI: 10.1038/Sj.Emboj.7601318  0.383
2006 Gong B, Cao Z, Zheng P, Vitolo OV, Liu S, Staniszewski A, Moolman D, Zhang H, Shelanski M, Arancio O. Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory. Cell. 126: 775-88. PMID 16923396 DOI: 10.1016/J.Cell.2006.06.046  0.472
2006 Puzzo D, Arancio O. Fibrillar beta-amyloid impairs the late phase of long term potentiation. Current Alzheimer Research. 3: 179-83. PMID 16842092 DOI: 10.2174/156720506777632871  0.48
2006 Yano H, Ninan I, Zhang H, Milner TA, Arancio O, Chao MV. BDNF-mediated neurotransmission relies upon a myosin VI motor complex. Nature Neuroscience. 9: 1009-18. PMID 16819522 DOI: 10.1038/Nn1730  0.417
2006 Moretti P, Levenson JM, Battaglia F, Atkinson R, Teague R, Antalffy B, Armstrong D, Arancio O, Sweatt JD, Zoghbi HY. Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 319-27. PMID 16399702 DOI: 10.1523/Jneurosci.2623-05.2006  0.45
2006 Puzzo D, Staniszewski A, Deng SX, Liu S, Palmeri A, Landry DW, Arancio O. P1-068: Synaptic and cognitive impairment in an amyloid-depositing mouse model after sildenafil treatment Alzheimer's & Dementia. 2: S114-S115. DOI: 10.1016/J.Jalz.2006.05.443  0.42
2006 Gong B, Cao Z, Zheng P, Vitolo O, Staniszewski A, Liu S, Moolman D, Zhang H, Shelanski M, Arancio O. P1-043: UCH-L1 is a critical regulator of synaptic and memory functions following amyloid elevation Alzheimer's & Dementia. 2: S106-S107. DOI: 10.1016/J.Jalz.2006.05.418  0.421
2006 Domenici L, Origlia N, Capsoni S, Cattaneo A, Arancio O, Yan SD. P3-427: Abeta (1-42) impairs LTP in mouse neocortex through rage mediated activation of p38 map kinase Alzheimer's & Dementia. 2: S501-S502. DOI: 10.1016/J.Jalz.2006.05.1698  0.342
2005 Puzzo D, Vitolo O, Trinchese F, Jacob JP, Palmeri A, Arancio O. Amyloid-beta peptide inhibits activation of the nitric oxide/cGMP/cAMP-responsive element-binding protein pathway during hippocampal synaptic plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 6887-97. PMID 16033898 DOI: 10.1523/Jneurosci.5291-04.2005  0.476
2005 Zhang H, Gong B, Liu S, Fa' M, Ninan I, Staniszewski A, Arancio O. Synaptic fatigue is more pronounced in the APP/PS1 transgenic mouse model of Alzheimer's disease. Current Alzheimer Research. 2: 137-40. PMID 15974910 DOI: 10.2174/1567205053585936  0.488
2005 Takuma K, Yao J, Huang J, Xu H, Chen X, Luddy J, Trillat AC, Stern DM, Arancio O, Yan SS. ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 597-8. PMID 15665036 DOI: 10.1096/Fj.04-2582Fje  0.393
2004 Gong B, Vitolo OV, Trinchese F, Liu S, Shelanski M, Arancio O. Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment. The Journal of Clinical Investigation. 114: 1624-34. PMID 15578094 DOI: 10.1172/Jci22831  0.528
2004 Liu S, Ninan I, Antonova I, Battaglia F, Trinchese F, Narasanna A, Kolodilov N, Dauer W, Hawkins RD, Arancio O. alpha-Synuclein produces a long-lasting increase in neurotransmitter release. The Embo Journal. 23: 4506-16. PMID 15510220 DOI: 10.1038/Sj.Emboj.7600451  0.34
2004 Arancio O, Zhang HP, Chen X, Lin C, Trinchese F, Puzzo D, Liu S, Hegde A, Yan SF, Stern A, Luddy JS, Lue LF, Walker DG, Roher A, Buttini M, et al. RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice. The Embo Journal. 23: 4096-105. PMID 15457210 DOI: 10.1038/Sj.Emboj.7600415  0.477
2004 Veeranna, Kaji T, Boland B, Odrljin T, Mohan P, Basavarajappa BS, Peterhoff C, Cataldo A, Rudnicki A, Amin N, Li BS, Pant HC, Hungund BL, Arancio O, Nixon RA. Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease. The American Journal of Pathology. 165: 795-805. PMID 15331404 DOI: 10.1016/S0002-9440(10)63342-1  0.397
2004 Trinchese F, Liu S, Ninan I, Puzzo D, Jacob JP, Arancio O. Cell cultures from animal models of Alzheimer's disease as a tool for faster screening and testing of drug efficacy. Journal of Molecular Neuroscience : Mn. 24: 15-21. PMID 15314245 DOI: 10.1385/Jmn:24:1:015  0.399
2004 Trinchese F, Liu S, Battaglia F, Walter S, Mathews PM, Arancio O. Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice. Annals of Neurology. 55: 801-14. PMID 15174014 DOI: 10.1002/Ana.20101  0.508
2004 Lustbader JW, Cirilli M, Lin C, Xu HW, Takuma K, Wang N, Caspersen C, Chen X, Pollak S, Chaney M, Trinchese F, Liu S, Gunn-Moore F, Lue LF, Walker DG, ... ... Arancio O, et al. ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science (New York, N.Y.). 304: 448-52. PMID 15087549 DOI: 10.1126/Science.1091230  0.406
2004 Ninan I, Arancio O. Presynaptic CaMKII is necessary for synaptic plasticity in cultured hippocampal neurons. Neuron. 42: 129-41. PMID 15066270 DOI: 10.1016/S0896-6273(04)00143-6  0.472
2004 Trinchese F, Ninan I, Liu S, Arancio O. P3-323 Alzheimer Aβ increases neuro-transmitter release and blocks synaptic plasticity in hippocampal cultures Neurobiology of Aging. 25: S447. DOI: 10.1016/S0197-4580(04)81473-8  0.464
2004 Gong B, Vitolo O, Shelanski M, Arancio O. P3-311 Beta-amyloid protein causes impairment of the ubiquitin-proteasome pathway and synaptic plasticity Neurobiology of Aging. 25: S443-S444. DOI: 10.1016/S0197-4580(04)81461-1  0.449
2004 Veeranna, Kaji T, Boland B, Odrljin T, Mohan P, Basavarajappa BS, Peterhoff C, Cataldo AM, Rudnicki A, Li BS, Pant HC, Hungund BL, Arancio O, Nixon RA. P1-272 Calpain mediates calcium-induced activation of the ERK 1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80585-2  0.369
2004 Yao J, Takuma K, Xu HW, Wang C, Stern D, Arancio O, Yan SD. O3-04-08 Role of ABAD in Aβ-mediated mitochondrial dysfunction in Alzheimer disease Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80205-7  0.345
2003 Battaglia F, Trinchese F, Liu S, Walter S, Nixon RA, Arancio O. Calpain inhibitors, a treatment for Alzheimer's disease: position paper. Journal of Molecular Neuroscience : Mn. 20: 357-62. PMID 14501020 DOI: 10.1385/Jmn:20:3:357  0.46
2003 Petrone A, Battaglia F, Wang C, Dusa A, Su J, Zagzag D, Bianchi R, Casaccia-Bonnefil P, Arancio O, Sap J. Receptor protein tyrosine phosphatase alpha is essential for hippocampal neuronal migration and long-term potentiation. The Embo Journal. 22: 4121-31. PMID 12912911 DOI: 10.1093/Emboj/Cdg399  0.427
2003 Sant'Angelo A, Trinchese F, Arancio O. Usefulness of behavioral and electrophysiological studies in transgenic models of Alzheimer's disease Neurochemical Research. 28: 1009-1015. PMID 12737525 DOI: 10.1023/A:1023251005197  0.411
2002 Vitolo OV, Sant'Angelo A, Costanzo V, Battaglia F, Arancio O, Shelanski M. Amyloid β-peptide inhibition of the PKA/CREB pathway and long-term potentiation: Reversibility by drugs that enhance cAMP signaling Proceedings of the National Academy of Sciences of the United States of America. 99: 13217-13221. PMID 12244210 DOI: 10.1073/Pnas.172504199  0.492
2002 Di Rosa G, Odrijin T, Nixon RA, Arancio O. Calpain inhibitors: a treatment for Alzheimer's disease. Journal of Molecular Neuroscience : Mn. 19: 135-41. PMID 12212771 DOI: 10.1007/s12031-002-0024-4  0.402
2001 Antonova I, Arancio O, Trillat AC, Wang HG, Zablow L, Udo H, Kandel ER, Hawkins RD. Rapid increase in clusters of presynaptic proteins at onset of long-lasting potentiation. Science (New York, N.Y.). 294: 1547-50. PMID 11641465 DOI: 10.1126/Science.1066273  0.552
2001 Arancio O, Antonova I, Gambaryan S, Lohmann SM, Wood JS, Lawrence DS, Hawkins RD. Presynaptic role of cGMP-dependent protein kinase during long-lasting potentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 143-9. PMID 11150330 DOI: 10.1523/Jneurosci.21-01-00143.2001  0.426
1998 Son H, Lu YF, Zhuo M, Arancio O, Kandel ER, Hawkins RD. The specific role of cGMP in hippocampal LTP. Learning & Memory (Cold Spring Harbor, N.Y.). 5: 231-45. PMID 10454367 DOI: 10.1101/Lm.5.3.231  0.531
1998 Arancio O. Morphological changes associated with long-term potentiation Histology and Histopathology. 13: 1155-1162. PMID 9810507  0.331
1996 Arancio O, Lev-Ram V, Tsien RY, Kandel ER, Hawkins RD. Nitric oxide acts as a retrograde messenger during long-term potentiation in cultured hippocampal neurons. Journal of Physiology, Paris. 90: 321-2. PMID 9089501 DOI: 10.1016/S0928-4257(97)87907-7  0.541
1996 Arancio O, Kiebler M, Lee CJ, Lev-Ram V, Tsien RY, Kandel ER, Hawkins RD. Nitric oxide acts directly in the presynaptic neuron to produce long-term potentiation in cultured hippocampal neurons. Cell. 87: 1025-35. PMID 8978607 DOI: 10.1016/S0092-8674(00)81797-3  0.547
1996 López-García JC, Arancio O, Kandel ER, Baranes D. A presynaptic locus for long-term potentiation of elementary synaptic transmission at mossy fiber synapses in culture. Proceedings of the National Academy of Sciences of the United States of America. 93: 4712-7. PMID 8643468 DOI: 10.1073/Pnas.93.10.4712  0.556
1995 Arancio O, Kandel ER, Hawkins RD. Activity-dependent long-term enhancement of transmitter release by presynaptic 3',5'-cyclic GMP in cultured hippocampal neurons. Nature. 376: 74-80. PMID 7596438 DOI: 10.1038/376074A0  0.584
1994 Hawkins RD, Zhuo M, Arancio O. Nitric oxide and carbon monoxide as possible retrograde messengers in hippocampal long-term potentiation Journal of Neurobiology. 25: 652-665. PMID 8071665 DOI: 10.1002/neu.480250607  0.314
1994 Arancio O, Korn H, Gulyas A, Freund T, Miles R. Excitatory synaptic connections onto rat hippocampal inhibitory cells may involve a single transmitter release site. The Journal of Physiology. 481: 395-405. PMID 7738832 DOI: 10.1113/Jphysiol.1994.Sp020448  0.36
1993 Arancio O, Yoshimura M, Murase K, MacDermott AB. The distribution of excitatory amino acid receptors on acutely dissociated dorsal horn neurons from postnatal rats. Neuroscience. 52: 159-67. PMID 8433804 DOI: 10.1016/0306-4522(93)90190-Q  0.337
1991 O'Dell TJ, Hawkins RD, Kandel ER, Arancio O. Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger. Proceedings of the National Academy of Sciences of the United States of America. 88: 11285-9. PMID 1684863 DOI: 10.1073/Pnas.88.24.11285  0.519
1990 MacDermott AB, Reichling DB, Arancio O. Mechanisms underlying excitatory amino acid-evoked calcium entry in cultured neurons from the embryonic rat spinal cord. Advances in Experimental Medicine and Biology. 268: 117-24. PMID 1963736 DOI: 10.1007/978-1-4684-5769-8_14  0.327
Low-probability matches (unlikely to be authored by this person)
1998 Hawkins RD, Son H, Arancio O. Nitric oxide as a retrograde messenger during long-term potentiation in hippocampus Progress in Brain Research. 118: 155-172. PMID 9932440 DOI: 10.1016/S0079-6123(08)63206-9  0.3
2019 Roy SM, Minasov G, Arancio O, Chico LW, Van Eldik LJ, Anderson WF, Pelletier JC, Watterson DM. A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction. Journal of Medicinal Chemistry. PMID 30978288 DOI: 10.1021/Acs.Jmedchem.9B00058  0.299
1991 Tiedge H, Fremeau RT, Weinstock PH, Arancio O, Brosius J. Dendritic location of neural BC1 RNA Proceedings of the National Academy of Sciences of the United States of America. 88: 2093-2097. PMID 1706516 DOI: 10.1073/Pnas.88.6.2093  0.299
2010 Pozueta J, Ribe E, Arancio O, Troy C, Shelanski M. O4-02-08: Caspase 2 is required for Aβ-induced spine loss Alzheimer's & Dementia. 6: S154-S154. DOI: 10.1016/J.Jalz.2010.05.480  0.299
2006 Ninan I, Arancio O, Rabinowitz D. Estimation of the mean from sums with unknown numbers of summands. Biometrics. 62: 918-20. PMID 16984336 DOI: 10.1111/J.1541-0420.2005.00518.X  0.295
2003 Di Rosa G, Puzzo D, Sant'Angelo A, Trinchese F, Arancio O. Alpha-synuclein: between synaptic function and dysfunction. Histology and Histopathology. 18: 1257-66. PMID 12973692 DOI: 10.14670/Hh-18.1257  0.294
1991 Arancio O, MacDermott AB. Differential distribution of excitatory amino acid receptors on embryonic rat spinal cord neurons in culture. Journal of Neurophysiology. 65: 899-913. PMID 1675674 DOI: 10.1152/Jn.1991.65.4.899  0.293
2010 Tamayev R, Matsuda S, Fa' M, Arancio O, D'Adamio L. O4-05-04: Do BRI2 mutations cause early onset Alzheimer's disease? Alzheimer's & Dementia. 6: S157-S158. DOI: 10.1016/J.Jalz.2010.05.491  0.286
2014 Ren H, Yan S, Zhang B, Lu TY, Arancio O, Accili D. Glut4 expression defines an insulin-sensitive hypothalamic neuronal population. Molecular Metabolism. 3: 452-9. PMID 24944904 DOI: 10.1016/J.Molmet.2014.04.006  0.286
2004 Moreno HW, Nava A, Tanji K, Puzzo D, Fukuyama H, Tang H, Westaway D, Arancio O, St. George Hyslop P, Small SA. P2-056 Imaging hippocampal dysfunction in transgenic mice with MRI Neurobiology of Aging. 25: S239. DOI: 10.1016/S0197-4580(04)80803-0  0.284
2010 Francis Y, Fa M, Zhang H, Saeed F, Staniszewski A, Arancio O. P2-329: Dysregulation of histone acetylation within the context of amyloid elevation Alzheimer's & Dementia. 6: S409-S410. DOI: 10.1016/J.Jalz.2010.05.1380  0.281
2010 Catalano SM, Ravesncroft J, Rehak C, Yurko R, Izzo N, Safferstein H, Rishton G, Staniszewski A, Arancio O. P4-091: Novel Anti-oligomer Compounds Stop Memory Deficits Alzheimer's & Dementia. 6: e49-e49. DOI: 10.1016/J.Jalz.2010.08.151  0.28
2003 Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, Belzung C, Hen R. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science (New York, N.Y.). 301: 805-9. PMID 12907793 DOI: 10.1126/Science.1083328  0.28
2019 Piacentini R, Puma DDL, Puzzo D, Gulisano W, Arancio O, Grassi C. F2-06-02: Trafficking Of Tau Oligomers Through The Plasma Membranes Of Neurons And Astrocytes Is Critical For Their Synaptotoxicity Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.4437  0.278
2022 Meier-Stephenson FS, Meier-Stephenson VC, Carter MD, Meek AR, Wang Y, Pan L, Chen Q, Jacobo S, Wu F, Lu E, Simms GA, Fisher L, McGrath AJ, Fermo V, Barden CJ, ... ... Arancio O, et al. Alzheimer's disease as an autoimmune disorder of innate immunity endogenously modulated by tryptophan metabolites. Alzheimer's & Dementia (New York, N. Y.). 8: e12283. PMID 35415204 DOI: 10.1002/trc2.12283  0.277
2019 Liu Y, Fiorito J, Gonzalez Y, Estrella B, Calcagno E, Zuccarello E, Hwang H, Honig B, Deng S, Landry D, O'Connor OA, Arancio O, Amengual JE. Strategy for Overcoming Crebbp and EP300 Mutations in Lymphoma: Development of First-in-Class HAT Activators Blood. 134: 4068-4068. DOI: 10.1182/Blood-2019-125983  0.276
2008 Kumar JR, Basavarajappa BS, Arancio O, Aranha I, Gangadhara NS, Yajurvedi HN, Gowda TV. Isolation and characterization of "Reprotoxin", a novel protein complex from Daboia russelii snake venom. Biochimie. 90: 1545-59. PMID 18573307 DOI: 10.1016/J.Biochi.2008.05.018  0.275
2022 Li Puma DD, Ripoli C, Puliatti G, Pastore F, Lazzarino G, Tavazzi B, Arancio O, Piacentini R, Grassi C. Extracellular tau oligomers affect extracellular glutamate handling by astrocytes through downregulation of GLT-1 expression and impairment of NKA1A2 function. Neuropathology and Applied Neurobiology. e12811. PMID 35274343 DOI: 10.1111/nan.12811  0.274
2020 Roy SM, Minasov G, Arancio O, Chico LW, Van Eldik LJ, Anderson WF, Pelletier JC, Watterson DM. Correction to "A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction". Journal of Medicinal Chemistry. PMID 32672466 DOI: 10.1021/Acs.Jmedchem.0C01060  0.272
1992 Arancio O, Buffelli M, Cangiano A, Pasino E. Nerve stump effects in muscle are independent of synaptic connections and are temporally correlated with nerve degeneration phenomena Neuroscience Letters. 146: 1-4. PMID 1475041 DOI: 10.1016/0304-3940(92)90157-3  0.269
2019 Gulisano W, Maugeri D, Baltrons MA, Fà M, Amato A, Palmeri A, D'Adamio L, Grassi C, Devanand DP, Honig LS, Puzzo D, Arancio O. Role of Amyloid-β and Tau Proteins in Alzheimer's Disease: Confuting the Amyloid Cascade. Journal of Alzheimer's Disease : Jad. 68: 415. PMID 30883364 DOI: 10.3233/JAD-189015  0.264
1991 Yoshimura M, Murase K, Arancio O, MacDermott AB. Glutamate receptor agonist-induced inward currents in spinal dorsal horn neurons dissociated from the adult rats. Neuroscience Research. 12: 528-35. PMID 1724559 DOI: 10.1016/S0168-0102(09)80005-9  0.261
2018 Liu Y, Fiorito J, Gonzalez Y, Zuccarello E, Calcagno E, Mazzeo A, Abshiru NA, Camarillo J, Kelleher NL, Qiao C, Nandakumar R, Serge C, Deng S, Landry D, O'Connor OA, ... Arancio O, et al. Development of First-in-Class Histone Acetyltransferase (HAT) Activators for Precision Targeting of Epigenetic Derangements in Lymphoma Blood. 132: 37-37. DOI: 10.1182/Blood-2018-99-110447  0.26
2018 Li H, Ham A, Ma TC, Kuo SH, Kanter E, Kim D, Ko HS, Quan Y, Sardi SP, Li A, Arancio O, Kang UJ, Sulzer D, Tang G. Mitochondrial Dysfunction and Mitophagy Defect Triggered by Heterozygous GBA Mutations. Autophagy. PMID 30160596 DOI: 10.1080/15548627.2018.1509818  0.259
2020 Han F, Bi J, Qiao L, Arancio O. Stem Cell Therapy for Alzheimer's Disease. Advances in Experimental Medicine and Biology. 1266: 39-55. PMID 33105494 DOI: 10.1007/978-981-15-4370-8_4  0.255
2015 Nestor MW, Jacob S, Sun B, Prè D, Sproul AA, Hong SI, Woodard C, Zimmer M, Chinchalongporn V, Arancio O, Noggle SA. Characterization of a subpopulation of developing cortical interneurons from human iPSCs within serum-free embryoid bodies. American Journal of Physiology. Cell Physiology. 308: C209-19. PMID 25394470 DOI: 10.1152/Ajpcell.00263.2014  0.255
2017 Wilkinson KA, Martin S, Tyagarajan SK, Arancio O, Craig TJ, Guo C, Fraser PE, Goldstein SAN, Henley JM. Commentary: Analysis of SUMO1-conjugation at synapses. Frontiers in Cellular Neuroscience. 11: 345. PMID 29163056 DOI: 10.3389/Fncel.2017.00345  0.247
2000 Battaglia F, Girlanda P, Vita G, Toscano A, Antonova I, Hawkins RD, Arancio O. Increase in α-synuclein immunoreactivity during long-term synaptic plasticity Neurological Sciences. 21: S134.  0.247
2015 Hue CD, Cho FS, Cao S, Nicholls RE, Vogel Iii EW, Sibindi C, Arancio O, Bass C', Meaney D, Morrison Iii B. Time Course and Size of Blood-Brain Barrier Opening in a Mouse Model of Blast-Induced Traumatic Brain Injury. Journal of Neurotrauma. PMID 26414212 DOI: 10.1089/Neu.2015.4067  0.245
1996 Pasino E, Buffelli M, Arancio O, Busetto G, Salviati A, Cangiano A. Effects of long-term conduction block on membrane properties of reinnervated and normally innervated rat skeletal muscle. The Journal of Physiology. 497: 457-72. PMID 8961187 DOI: 10.1113/Jphysiol.1996.Sp021780  0.244
2018 Gu CJ, Borjabad A, Hadas E, Kelschenbach J, Kim BH, Chao W, Arancio O, Suh J, Polsky B, McMillan J, Edagwa B, Gendelman HE, Potash MJ, Volsky DJ. EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment. Plos Pathogens. 14: e1007061. PMID 29879225 DOI: 10.1371/Journal.Ppat.1007061  0.232
1988 Provenzano C, Arancio O, Evoli A, Rocca B, Bartoccioni E, Grandis DD, Tonali P. Familial autoimmune myasthenia gravis with different pathogenetic antibodies Journal of Neurology, Neurosurgery and Psychiatry. 51: 1228-1230. PMID 3225607 DOI: 10.1136/Jnnp.51.9.1228  0.228
2010 Sakurai M, Yamamoto A, Arancio O. On the role of SUMOylation in the developing murine forebrain Neuroscience Research. 68: e89. DOI: 10.1016/J.Neures.2010.07.160  0.227
2019 Liu Y, Fiorito J, Gonzale Y, Zuccarello E, Calcagno E, Camarillo J, Thomas P, Kelleher N, Deng S, Landry D, O'Connor O, Wolfe A, Moyer B, Arancio O, Amengual J. FIRST-IN-CLASS HAT ACTIVATOR HIGHLY SYNERGISTIC WITH PAN-HDAC INHIBITOR ROMIDEPSIN LEADING TO PROFOUND HISTONE ACETYLATION CYTOTOXICITY Hematological Oncology. 37: 125-126. DOI: 10.1002/Hon.85_2629  0.219
1985 Arancio O, Cangiano A, Grandis DD, Mezzina C, Perli C, Rodegher G. Poster Myopathy and myastheniaSpontaneous activity in partial and total denervation Electroencephalography and Clinical Neurophysiology. 61. DOI: 10.1016/0013-4694(85)90349-9  0.219
1989 Arancio O, Cangiano A, De Grandis D. Fibrillatory activity and other membrane changes in partially denervated muscles Muscle and Nerve. 12: 149-153. PMID 2710147 DOI: 10.1002/Mus.880120210  0.214
1988 Arancio O, Bongiovanni LG, Bonadonna G, Tomelleri G, De Grandis D. Congenital muscular dystrophy and cerebellar vermis agenesis in two brothers The Italian Journal of Neurological Sciences. 9: 485-489. PMID 3215750 DOI: 10.1007/Bf02337167  0.214
2018 Evans LP, Newell EA, Mahajan M, Tsang SH, Ferguson PJ, Mahoney J, Hue CD, Vogel EW, Morrison B, Arancio O, Nichols R, Bassuk AG, Mahajan VB. Acute vitreoretinal trauma and inflammation after traumatic brain injury in mice. Annals of Clinical and Translational Neurology. 5: 240-251. PMID 29560370 DOI: 10.1002/Acn3.523  0.211
1989 Arancio O, Bonadonna G, Calvani M, Giovene P, Tomelleri G, De Grandis D. Transitory l-carnitine depletion in rat skeletal muscle by d-carnitine Pharmacological Research. 21: 163-168. PMID 2748504 DOI: 10.1016/1043-6618(89)90234-X  0.205
1988 Arancio O, Cangiano A, Magherini PC, Pasino E. Effects of reinnervation with normal and tetrodotoxin-inactive nerves on resting membrane potential of rat skeletal muscle. Neuroscience Letters. 88: 179-83. PMID 3380356 DOI: 10.1016/0304-3940(88)90122-X  0.202
2008 Arancio O. PIP2: a new key player in Alzheimer's disease. Cellscience. 5: 44-47. PMID 20577650  0.198
2023 Hainsworth AH, Arancio O, Elahi FM, Isaacs JD, Cheng F. PDE5 inhibitor drugs for use in dementia. Alzheimer's & Dementia (New York, N. Y.). 9: e12412. PMID 37766832 DOI: 10.1002/trc2.12412  0.193
1985 Arancio O, Bongiovanni LG, De Grandis D. Acute peroneal compartmental syndrome: Report of a case European Neurology. 24: 69-72. PMID 3967679 DOI: 10.1159/000115764  0.187
2000 Battaglla E, Yamamoto A, Girlanda P, Vita G, Toscano A, Hen R, Arancio O. Impaired long-term potentiation in a conditional model of huntington's disease Neurological Sciences. 21: S134-S135.  0.181
2023 Dridi H, Liu Y, Reiken S, Liu X, Argyrousi EK, Yuan Q, Miotto MC, Sittenfeld L, Meddar A, Soni RK, Arancio O, Lacampagne A, Marks AR. Heart failure-induced cognitive dysfunction is mediated by intracellular Ca leak through ryanodine receptor type 2. Nature Neuroscience. PMID 37429912 DOI: 10.1038/s41593-023-01377-6  0.178
2006 Small S, Yu R, Muhammad A, Zhang H, Flores I, Planel E, Arancio O, Duff K, Honig L. O2-03-04 Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.123  0.175
2021 Ginsberg SD, Joshi S, Sharma S, Guzman G, Wang T, Arancio O, Chiosis G. The penalty of stress - epichaperomes negatively reshaping the brain in neurodegenerative disorders. Journal of Neurochemistry. PMID 34657288 DOI: 10.1111/jnc.15525  0.158
2015 Moreno L, Rose C, Mohanraj A, Allinquant B, Billard JM, Dutar P, Arancio O. sAβPPα improves hippocampal NMDA-dependent functional alterations linked to healthy aging Journal of Alzheimer's Disease. 48: 927-935. DOI: 10.3233/JAD-150297  0.151
2012 Puzzo D, Arancio O. Amyloid-β peptide: Dr. Jekyll or Mr. Hyde? Advances in Alzheimer's Disease. 3: 111-120. DOI: 10.3233/978-1-61499-154-0-111  0.128
1982 Arancio O, Cangiano A, Magherini PC. [Role of NGF in the development of primary sensory neurons in the rat]. Bollettino Della Societã  Italiana Di Biologia Sperimentale. 58: 60-5. PMID 7066100  0.122
2015 Chinchalongporn V, Koppensteiner P, Prè D, Thangnipon W, Bilo L, Arancio O. Connectivity and circuitry in a dish versus in a brain Alzheimer's Research and Therapy. DOI: 10.1186/s13195-015-0129-y  0.078
1986 De Grandis D, Arancio O, Serra G. An electroneurographic response Muscle & Nerve. 9: 185-186. PMID 3951492  0.011
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