Frank LaFerla, Ph.D. - Related publications

Affiliations: 
Neurobiology & Behavior University of California, Irvine, Irvine, CA 
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50 most relevant papers in past 60 days:
Year Citation  Score
2019 Šimić G, Španić E, Langer Horvat L, Hof PR. Blood-brain barrier and innate immunity in the pathogenesis of Alzheimer's disease. Progress in Molecular Biology and Translational Science. 168: 99-145. PMID 31699331 DOI: 10.1016/bs.pmbts.2019.06.003   
2019 Metaxas A, Thygesen C, Kempf SJ, Anzalone M, Vaitheeswaran R, Petersen S, Landau AM, Audrain H, Teeling JL, Darvesh S, Brooks DJ, Larsen MR, Finsen B. Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer's disease. Scientific Reports. 9: 15758. PMID 31673052 DOI: 10.1038/s41598-019-52357-5   
2019 Ahmad SS, Khan S, Kamal MA, Wasi U. The structure and function of α, β and γ-Secretase as therapeutic target enzymes into the development of Alzheimer's disease: A review. Cns & Neurological Disorders Drug Targets. PMID 31608840 DOI: 10.2174/1871527318666191011145941   
2019 Pulina MV, Hopkins M, Haroutunian V, Greengard P, Bustos V. C99 selectively accumulates in vulnerable neurons in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 31677937 DOI: 10.1016/j.jalz.2019.09.002   
2019 Chen X, Xu B, Nie L, He K, Zhou L, Huang X, Spencer P, Yang X, Liu J. Flavanol-rich lychee fruit extract substantially reduces progressive cognitive and molecular deficits in a triple-transgenic animal model of Alzheimer disease. Nutritional Neuroscience. 1-15. PMID 31603034 DOI: 10.1080/1028415X.2019.1673527   
2019 Grimaldi A, Pediconi N, Oieni F, Pizzarelli R, Rosito M, Giubettini M, Santini T, Limatola C, Ruocco G, Ragozzino D, Di Angelantonio S. Neuroinflammatory Processes, A1 Astrocyte Activation and Protein Aggregation in the Retina of Alzheimer's Disease Patients, Possible Biomarkers for Early Diagnosis. Frontiers in Neuroscience. 13: 925. PMID 31551688 DOI: 10.3389/fnins.2019.00925   
2019 Choi H, Kim HJ, Yang J, Chae S, Lee W, Chung S, Kim J, Choi H, Song H, Lee CK, Jun JH, Lee YJ, Lee K, Kim S, Sim HR, et al. Acetylation changes tau interactome to degrade tau in Alzheimer's disease animal and organoid models. Aging Cell. e13081. PMID 31763743 DOI: 10.1111/acel.13081   
2019 Shin WS, Di J, Cao Q, Li B, Seidler PM, Murray KA, Bitan G, Jiang L. Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation. Alzheimer's Research & Therapy. 11: 86. PMID 31627745 DOI: 10.1186/s13195-019-0541-9   
2019 Jacob S, Davies G, De Bock M, Hermans B, Wintmolders C, Bottelbergs A, Borgers M, Theunis C, Van Broeck B, Manyakov NV, Balschun D, Drinkenburg WHIM. Neural oscillations during cognitive processes in an App knock-in mouse model of Alzheimer's disease pathology. Scientific Reports. 9: 16363. PMID 31705038 DOI: 10.1038/s41598-019-51928-w   
2019 Fuchsberger T, Yuste R, Martinez-Bellver S, Blanco-Gandia MC, Torres-Cuevas I, Blasco-Serra A, Arango R, Miñarro J, Rodríguez-Arias M, Teruel-Marti V, Lloret A, Viña J. Oral Monosodium Glutamate Administration Causes Early Onset of Alzheimer's Disease-Like Pathophysiology in APP/PS1 Mice. Journal of Alzheimer's Disease : Jad. PMID 31658055 DOI: 10.3233/JAD-190274   
2019 Michelson D, Grundman M, Magnuson K, Fisher R, Levenson JM, Aisen P, Marek K, Gray M, Hefti F. Randomized, Placebo Controlled Trial of NPT088, A Phage-Derived, Amyloid-Targeted Treatment for Alzheimer's Disease. The Journal of Prevention of Alzheimer's Disease. 6: 228-231. PMID 31686093 DOI: 10.14283/jpad.2019.37   
2019 Boese AC, Hamblin MH, Lee JP. Neural stem cell therapy for neurovascular injury in Alzheimer's disease. Experimental Neurology. 113112. PMID 31730762 DOI: 10.1016/j.expneurol.2019.113112   
2019 Paasila PJ, Davies DS, Kril JJ, Goldsbury C, Sutherland GT. The relationship between the morphological subtypes of microglia and Alzheimer's disease neuropathology. Brain Pathology (Zurich, Switzerland). 29: 726-740. PMID 30803086 DOI: 10.1111/bpa.12717   
2019 Wu H, Wu ZG, Shi WJ, Gao H, Wu HH, Bian F, Jia PP, Hou YN. Effects of progesterone on glucose uptake in neurons of Alzheimer's disease animals and cell models. Life Sciences. 116979. PMID 31647947 DOI: 10.1016/j.lfs.2019.116979   
2019 Sho M, Ichiyanagi N, Imaizumi K, Ishikawa M, Morimoto S, Watanabe H, Okano H. A combinational treatment of carotenoids decreases Aβ secretion in human neurons via β-secretase inhibition. Neuroscience Research. PMID 31606373 DOI: 10.1016/j.neures.2019.10.006   
2019 Wu S, Liu H, Zhao H, Wang X, Chen J, Xia D, Xiao C, Cheng J, Zhao Z, He Y. Environmental Lead Exposure Aggravates the Progression of Alzheimer's Disease in Mice by Targeting on Blood Brain Barrier. Toxicology Letters. PMID 31730887 DOI: 10.1016/j.toxlet.2019.11.009   
2019 Liu PP, Xie Y, Meng XY, Kang JS. History and progress of hypotheses and clinical trials for Alzheimer's disease. Signal Transduction and Targeted Therapy. 4: 29. PMID 31637009 DOI: 10.1038/s41392-019-0063-8   
2019 Iqbal K, Liu F, Gong C, Dai C, Hu W. Why delay in effective treatment for Alzheimer's disease and related conditions. Progress in Molecular Biology and Translational Science. 168: 243-256. PMID 31699318 DOI: 10.1016/bs.pmbts.2019.08.002   
2019 Zhang H, Zheng Y. [β Amyloid Hypothesis in Alzheimer's Disease:Pathogenesis,Prevention,and Management]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae. 41: 702-708. PMID 31699204 DOI: 10.3881/j.issn.1000-503X.10875   
2019 Wessels AM, Tariot PN, Zimmer JA, Selzler KJ, Bragg SM, Andersen SW, Landry J, Krull JH, Downing AM, Willis BA, Shcherbinin S, Mullen J, Barker P, Schumi J, Shering C, et al. Efficacy and Safety of Lanabecestat for Treatment of Early and Mild Alzheimer Disease: The AMARANTH and DAYBREAK-ALZ Randomized Clinical Trials. Jama Neurology. PMID 31764959 DOI: 10.1001/jamaneurol.2019.3988   
2019 Griebel G, Stemmelin J, Lopez-Grancha M, Boulay D, Boquet G, Slowinski F, Pichat P, Beeské S, Tanaka S, Mori A, Fujimura M, Eguchi J. The selective GSK3 inhibitor, SAR502250, displays neuroprotective activity and attenuates behavioral impairments in models of neuropsychiatric symptoms of Alzheimer's disease in rodents. Scientific Reports. 9: 18045. PMID 31792284 DOI: 10.1038/s41598-019-54557-5   
2019 Zhang Z, Shen Q, Wu X, Zhang D, Xing D. Activation of PKA/SIRT1 signaling pathway by photobiomodulation therapy reduces Aβ levels in Alzheimer's disease models. Aging Cell. e13054. PMID 31663252 DOI: 10.1111/acel.13054   
2019 Huynh TV, Wang C, Tran AC, Tabor GT, Mahan TE, Francis CM, Finn MB, Spellman R, Manis M, Tanzi RE, Ulrich JD, Holtzman DM. Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model. Molecular Neurodegeneration. 14: 37. PMID 31623648 DOI: 10.1186/s13024-019-0337-1   
2019 Long JM, Holtzman DM. Alzheimer Disease: An Update on Pathobiology and Treatment Strategies. Cell. 179: 312-339. PMID 31564456 DOI: 10.1016/j.cell.2019.09.001   
2019 Webers A, Heneka MT, Gleeson PA. The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer's disease. Immunology and Cell Biology. PMID 31654430 DOI: 10.1111/imcb.12301   
2019 van der Velpen V, Teav T, Gallart-Ayala H, Mehl F, Konz I, Clark C, Oikonomidi A, Peyratout G, Henry H, Delorenzi M, Ivanisevic J, Popp J. Systemic and central nervous system metabolic alterations in Alzheimer's disease. Alzheimer's Research & Therapy. 11: 93. PMID 31779690 DOI: 10.1186/s13195-019-0551-7   
2019 Wang Z, Cao M, Xiang H, Wang W, Feng X, Yang X. WBQ5187, a Multitarget, Directed Agent, Ameliorates Cognitive Impairment in a Transgenic Mouse Model of Alzheimer's Disease and Modulates Cerebral β-amyloid, Gliosis, cAMP Levels and Neurodegeneration. Acs Chemical Neuroscience. PMID 31697472 DOI: 10.1021/acschemneuro.9b00409   
2019 Thal DR, Ronisz A, Tousseyn T, Rijal Upadhaya A, Balakrishnan K, Vandenberghe R, Vandenbulcke M, von Arnim CAF, Otto M, Beach TG, Lilja J, Heurling K, Chakrabarty A, Ismail A, Buckley C, et al. Different aspects of Alzheimer's disease-related amyloid β-peptide pathology and their relationship to amyloid positron emission tomography imaging and dementia. Acta Neuropathologica Communications. 7: 178. PMID 31727169 DOI: 10.1186/s40478-019-0837-9   
2019 Bailey DK, Kosman DJ. Is brain iron trafficking part of the physiology of the amyloid precursor protein? Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. PMID 31578640 DOI: 10.1007/s00775-019-01684-z   
2019 Sun X, Nie B, Zhao S, Chen Q, Li P, Zhang T, Pan T, Feng T, Wang L, Yin X, Zhang W, Zhao S, Shan B, Liu H, Liang S, et al. Tau PET distributional pattern in AD patients with visuospatial dysfunction. Current Alzheimer Research. PMID 31724513 DOI: 10.2174/1567205016666191113152434   
2019 Sheu JJ, Yang LY, Renuka Sanotra M, Wang ST, Lu HT, Sook Yee Kam R, Hsu IU, Kao SH, Lee CK, Chang-Cheng Shieh J, Lin YF. Reduction of AHI1 in the serum of Taiwanese with probable Alzheimer's disease. Clinical Biochemistry. PMID 31786207 DOI: 10.1016/j.clinbiochem.2019.11.011   
2019 Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt SV, Vieira-Saecker A, Schwartz S, Albasset S, McManus RM, Tejera D, Griep A, Santarelli F, Brosseron F, Opitz S, Stunden J, et al. NLRP3 inflammasome activation drives tau pathology. Nature. PMID 31748742 DOI: 10.1038/s41586-019-1769-z   
2019 Kisby B, Jarrell JT, Agar ME, Cohen DS, Rosin ER, Cahill CM, Rogers JT, Huang X. Alzheimer's Disease and Its Potential Alternative Therapeutics. Journal of Alzheimer's Disease & Parkinsonism. 9. PMID 31588368 DOI: 10.4172/2161-0460.1000477   
2019 Jokar S, Khazaei S, Behnammanesh H, Shamloo A, Erfani M, Beiki D, Bavi O. Recent advances in the design and applications of amyloid-β peptide aggregation inhibitors for Alzheimer's disease therapy. Biophysical Reviews. PMID 31713720 DOI: 10.1007/s12551-019-00606-2   
2019 Li TR, Wang XN, Sheng C, Li YX, Li FZ, Sun Y, Han Y. Extracellular vesicles as an emerging tool for the early detection of Alzheimer's disease. Mechanisms of Ageing and Development. 111175. PMID 31678325 DOI: 10.1016/j.mad.2019.111175   
2019 Yu L, Boyle PA, Dawe RJ, Bennett DA, Arfanakis K, Schneider JA. Contribution of TDP and hippocampal sclerosis to hippocampal volume loss in older-old persons. Neurology. PMID 31757868 DOI: 10.1212/WNL.0000000000008679   
2019 Liu K, Ma C, Su J, Sun Y, Shen N, Li B, Feng Y, Yang X, Wu H, Zhang H, Herrmann A, Tanzi R, Zhang C. Significant upregulation of Alzheimer's β-amyloid levels in living system induced by extracellular elastin polypeptides. Angewandte Chemie (International Ed. in English). PMID 31609093 DOI: 10.1002/anie.201912399   
2019 Bamford RA, Widagdo J, Takamura N, Eve M, Anggono V, Oguro-Ando A. The Interaction Between Contactin and Amyloid Precursor Protein and Its Role in Alzheimer's Disease. Neuroscience. PMID 31705890 DOI: 10.1016/j.neuroscience.2019.10.006   
2019 Zhuang L, Peng F, Huang Y, Li W, Huang J, Chu Y, Ren P, Sun Y, Zhang Y, Xue E, Guo X, Shen X, Xue L. CHIP modulates APP-induced autophagy-dependent pathological symptoms in Drosophila. Aging Cell. e13070. PMID 31777182 DOI: 10.1111/acel.13070   
2019 Ben-Nejma IRH, Keliris AJ, Daans J, Ponsaerts P, Verhoye M, Van der Linden A, Keliris GA. Increased soluble amyloid-beta causes early aberrant brain network hypersynchronisation in a mature-onset mouse model of amyloidosis. Acta Neuropathologica Communications. 7: 180. PMID 31727182 DOI: 10.1186/s40478-019-0810-7   
2019 Howard R, Zubko O, Bradley R, Harper E, Pank L, O'Brien J, Fox C, Tabet N, Livingston G, Bentham P, McShane R, Burns A, Ritchie C, Reeves S, Lovestone S, ... , et al. Minocycline at 2 Different Dosages vs Placebo for Patients With Mild Alzheimer Disease: A Randomized Clinical Trial. Jama Neurology. PMID 31738372 DOI: 10.1001/jamaneurol.2019.3762   
2019 Griner SL, Seidler P, Bowler J, Murray KA, Yang TP, Sahay S, Sawaya MR, Cascio D, Rodriguez JA, Philipp S, Sosna J, Glabe CG, Gonen T, Eisenberg DS. Structure based inhibitors of Amyloid Beta core suggest a common interface with Tau. Elife. 8. PMID 31612856 DOI: 10.7554/eLife.46924   
2019 Joshi P, Kawade V, Dhulap S, Goel M. Unlocking the concealed targets using system biology mapping for Alzheimer's disease. Pharmacological Reports : Pr. 71: 1104-1107. PMID 31634797 DOI: 10.1016/j.pharep.2019.06.012   
2019 Wang S, Lin B, Lin G, Sun C, Lin R, Huang J, Tao J, Wang X, Wu Y, Chen L, Chen J. Label-free multiphoton imaging of -amyloid plaques in Alzheimer's disease mouse models. Neurophotonics. 6: 045008. PMID 31737743 DOI: 10.1117/1.NPh.6.4.045008   
2019 Zhou R, Yang G, Shi Y. Macromolecular complex in recognition and proteolysis of amyloid precursor protein in Alzheimer's disease. Current Opinion in Structural Biology. 61: 1-8. PMID 31629221 DOI: 10.1016/j.sbi.2019.09.004   
2019 Morrone CD, Bazzigaluppi P, Beckett TL, Hill ME, Koletar MM, Stefanovic B, McLaurin J. Regional differences in Alzheimer's disease pathology confound behavioural rescue after amyloid-β attenuation. Brain : a Journal of Neurology. PMID 31782760 DOI: 10.1093/brain/awz371   
2019 García-González L, Pilat D, Baranger K, Rivera S. Emerging Alternative Proteinases in APP Metabolism and Alzheimer's Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP. Frontiers in Aging Neuroscience. 11: 244. PMID 31607898 DOI: 10.3389/fnagi.2019.00244   
2019 Vander Zanden CM, Chi EY. Passive immunotherapies targeting amyloid beta and tau oligomers in Alzheimer's disease. Journal of Pharmaceutical Sciences. PMID 31647950 DOI: 10.1016/j.xphs.2019.10.024   
2019 Hong G, Zeng P, Li N, Cai H, Guo Y, Li X, Li K, Li H. A Qualitative Analysis Based on Relative Expression Orderings Identifies Transcriptional Subgroups for Alzheimer's Disease. Current Alzheimer Research. PMID 31763973 DOI: 10.2174/1567205016666191122125035   
2019 Carandini T, Arighi A, Sacchi L, Fumagalli GG, Pietroboni AM, Ghezzi L, Colombi A, Scarioni M, Fenoglio C, De Riz MA, Marotta G, Scarpini E, Galimberti D. Testing the 2018 NIA-AA research framework in a retrospective large cohort of patients with cognitive impairment: from biological biomarkers to clinical syndromes. Alzheimer's Research & Therapy. 11: 84. PMID 31615545 DOI: 10.1186/s13195-019-0543-7