| Year |
Citation |
Score |
| 2024 |
Yin JZ, Keszei AFA, Houliston S, Filandr F, Beenstock J, Daou S, Kitaygorodsky J, Schriemer DC, Mazhab-Jafari MT, Gingras AC, Sicheri F. The HisRS-like domain of GCN2 is a pseudoenzyme that can bind uncharged tRNA. Structure (London, England : 1993). PMID 38531363 DOI: 10.1016/j.str.2024.02.021 |
0.444 |
|
| 2024 |
Maisonneuve P, Sahmi M, Bergeron-Labrecque F, Ma XI, Queguiner J, Arseneault G, Lefrançois M, Kurinov I, Fronzes R, Sicheri F, Therrien M. The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction. Nature Structural & Molecular Biology. PMID 38388830 DOI: 10.1038/s41594-024-01233-6 |
0.375 |
|
| 2023 |
Tessier TM, Chowdhury A, Stekel Z, Fux J, Sartori MA, Teyra J, Jarvik N, Chung J, Kurinov I, Sicheri F, Sidhu SS, Singer AU, Zhang W. Structural and functional validation of a highly specific Smurf2 inhibitor. Protein Science : a Publication of the Protein Society. e4885. PMID 38147466 DOI: 10.1002/pro.4885 |
0.344 |
|
| 2022 |
Kelso S, O'Brien S, Kurinov I, Angers S, Sicheri F. Crystal structure of the CDK11 kinase domain bound to the small-molecule inhibitor OTS964. Structure (London, England : 1993). 30: 1615-1625.e4. PMID 36327972 DOI: 10.1016/j.str.2022.10.003 |
0.412 |
|
| 2022 |
Beenstock J, Ona SM, Sicheri F. A suite of in vitro and in vivo assays for monitoring the activity of the pseudokinase Bud32. Methods in Enzymology. 667: 729-773. PMID 35525560 DOI: 10.1016/bs.mie.2022.03.052 |
0.408 |
|
| 2022 |
Veggiani G, Yates BP, Martyn GD, Manczyk N, Singer AU, Kurinov I, Sicheri F, Sidhu SS. Panel of Engineered Ubiquitin Variants Targeting the Family of Human Ubiquitin Interacting Motifs. Acs Chemical Biology. 17: 941-956. PMID 35385646 DOI: 10.1021/acschembio.2c00089 |
0.361 |
|
| 2021 |
Beenstock J, Sicheri F. The structural and functional workings of KEOPS. Nucleic Acids Research. 49: 10818-10834. PMID 34614169 DOI: 10.1093/nar/gkab865 |
0.341 |
|
| 2021 |
Tavernier N, Sicheri F, Pintard L. Aurora A kinase activation: Different means to different ends. The Journal of Cell Biology. 220. PMID 34287649 DOI: 10.1083/jcb.202106128 |
0.344 |
|
| 2021 |
Teyra J, McLaughlin M, Singer A, Kelil A, Ernst A, Sicheri F, Sidhu SS. Comprehensive Assessment of The Relationship Between Site Specificity and Helix α2 in the Erbin PDZ Domain. Journal of Molecular Biology. 167115. PMID 34171344 DOI: 10.1016/j.jmb.2021.167115 |
0.325 |
|
| 2021 |
Kelso S, Orlicky S, Beenstock J, Ceccarelli DF, Kurinov I, Gish G, Sicheri F. Bipartite binding of the N terminus of Skp2 to cyclin A. Structure (London, England : 1993). PMID 33989513 DOI: 10.1016/j.str.2021.04.011 |
0.387 |
|
| 2020 |
Daou S, Talukdar M, Tang J, Dong B, Banerjee S, Li Y, Duffy NM, Ogunjimi AA, Gaughan C, Jha BK, Gish G, Tavernier N, Mao D, Weiss SR, Huang H, ... ... Sicheri F, et al. A phenolic small molecule inhibitor of RNase L prevents cell death from ADAR1 deficiency. Proceedings of the National Academy of Sciences of the United States of America. PMID 32958664 DOI: 10.1073/Pnas.2006883117 |
0.359 |
|
| 2020 |
Posternak G, Tang X, Maisonneuve P, Jin T, Lavoie H, Daou S, Orlicky S, Goullet de Rugy T, Caldwell L, Chan K, Aman A, Prakesch M, Poda G, Mader P, Wong C, ... ... Sicheri F, et al. Functional characterization of a PROTAC directed against BRAF mutant V600E. Nature Chemical Biology. PMID 32778845 DOI: 10.1038/S41589-020-0609-7 |
0.418 |
|
| 2020 |
Wiechmann S, Maisonneuve P, Grebbin BM, Hoffmeister M, Kaulich M, Clevers H, Rajalingam K, Kurinov I, Farin HF, Sicheri F, Ernst A. Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids. The Journal of Biological Chemistry. PMID 32086379 DOI: 10.1074/Jbc.Ra119.011025 |
0.355 |
|
| 2019 |
Hill S, Reichermeier K, Scott DC, Samentar L, Coulombe-Huntington J, Izzi L, Tang X, Ibarra R, Bertomeu T, Moradian A, Sweredoski MJ, Caberoy N, Schulman BA, Sicheri F, Tyers M, et al. Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways. Elife. 8. PMID 31868589 DOI: 10.7554/Elife.51163 |
0.338 |
|
| 2019 |
Teyra J, Ernst A, Singer A, Sicheri F, Sidhu SS. Comprehensive analysis of all evolutionary paths between two divergent PDZ domain specificities. Protein Science : a Publication of the Protein Society. PMID 31654425 DOI: 10.1002/Pro.3759 |
0.45 |
|
| 2019 |
Garg P, Ceccarelli DF, Keszei AF, Kourinov I, Sicheri F, Sidhu SS. Structural and Functional Analysis of Ubiquitin-based inhibitors that Target the Backsides of E2 Enzymes. Journal of Molecular Biology. PMID 31634471 DOI: 10.1016/J.Jmb.2019.09.024 |
0.371 |
|
| 2019 |
Assadieskandar A, Yu C, Maisonneuve P, Kurinov I, Sicheri F, Zhang C. Rigidification Dramatically Improves Inhibitor Selectivity for RAF Kinases. Acs Medicinal Chemistry Letters. 10: 1074-1080. PMID 31312411 DOI: 10.1021/Acsmedchemlett.9B00194 |
0.458 |
|
| 2019 |
Ceccarelli DF, Ivantsiv S, Mullin AA, Coyaud E, Manczyk N, Maisonneuve P, Kurinov I, Zhao L, Go C, Gingras AC, Raught B, Cordes S, Sicheri F. FAM105A/OTULINL Is a Pseudodebuiquitinase of the OTU-Class that Localizes to the ER Membrane. Structure (London, England : 1993). PMID 31056421 DOI: 10.1016/J.Str.2019.03.022 |
0.464 |
|
| 2019 |
Manczyk N, Veggiani G, Teyra J, Strilchuk AW, Sidhu SS, Sicheri F. The ubiquitin interacting motifs of USP37 act on the proximal Ub of a di-Ub chain to enhance catalytic efficiency. Scientific Reports. 9: 4119. PMID 30858488 DOI: 10.1038/S41598-019-40815-Z |
0.394 |
|
| 2019 |
Manczyk N, Veggiani G, Gish GD, Yates BP, Ernst A, Sidhu SS, Sicheri F. Dimerization of a ubiquitin variant leads to high affinity interactions with a ubiquitin interacting motif. Protein Science : a Publication of the Protein Society. PMID 30793400 DOI: 10.1002/Pro.3593 |
0.372 |
|
| 2019 |
Pascoe N, Seetharaman A, Teyra J, Manczyk N, Satori MA, Tjandra D, Makhnevych T, Schwerdtfeger C, Brasher BB, Moffat J, Costanzo M, Boone C, Sicheri F, Sidhu S. Yeast Two-Hybrid Analysis for Ubiquitin-Variant Inhibitors of Human Deubiquitinases. Journal of Molecular Biology. PMID 30763569 DOI: 10.1016/J.Jmb.2019.02.007 |
0.364 |
|
| 2019 |
Teyra J, Singer AU, Schmitges FW, Jaynes P, Kit Leng Lui S, Polyak MJ, Fodil N, Krieger JR, Tong J, Schwerdtfeger C, Brasher BB, Ceccarelli DFJ, Moffat J, Sicheri F, Moran MF, et al. Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15. Structure (London, England : 1993). PMID 30713027 DOI: 10.1016/J.Str.2019.01.002 |
0.484 |
|
| 2018 |
Daou S, Barbour H, Ahmed O, Masclef L, Baril C, Sen Nkwe N, Tchelougou D, Uriarte M, Bonneil E, Ceccarelli D, Mashtalir N, Tanji M, Masson JY, Thibault P, Sicheri F, et al. Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1. Nature Communications. 9: 4385. PMID 30349006 DOI: 10.1038/S41467-018-06854-2 |
0.363 |
|
| 2018 |
Gill MK, Christova T, Zhang YY, Gregorieff A, Zhang L, Narimatsu M, Song S, Xiong S, Couzens AL, Tong J, Krieger JR, Moran MF, Zlotta AR, van der Kwast TH, Gingras AC, ... Sicheri F, et al. A feed forward loop enforces YAP/TAZ signaling during tumorigenesis. Nature Communications. 9: 3510. PMID 30158528 DOI: 10.1038/S41467-018-05939-2 |
0.32 |
|
| 2018 |
Hunter RW, Hughey CC, Lantier L, Sundelin EI, Peggie M, Zeqiraj E, Sicheri F, Jessen N, Wasserman DH, Sakamoto K. Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase. Nature Medicine. PMID 30150719 DOI: 10.1038/S41591-018-0159-7 |
0.319 |
|
| 2018 |
Gorelik M, Manczyk N, Pavlenco A, Kurinov I, Sidhu SS, Sicheri F. A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases. Structure (London, England : 1993). PMID 30033217 DOI: 10.1016/J.Str.2018.06.004 |
0.37 |
|
| 2018 |
Xiong S, Lorenzen K, Couzens AL, Templeton CM, Rajendran D, Mao DYL, Juang YC, Chiovitti D, Kurinov I, Guettler S, Gingras AC, Sicheri F. Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment. Structure (London, England : 1993). PMID 29983373 DOI: 10.1016/J.Str.2018.05.014 |
0.532 |
|
| 2018 |
Zhao N, Cao J, Xu L, Tang Q, Dobrolecki LE, Lv X, Talukdar M, Lu Y, Wang X, Hu DZ, Shi Q, Xiang Y, Wang Y, Liu X, Bu W, ... ... Sicheri F, et al. Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer. The Journal of Clinical Investigation. PMID 29480818 DOI: 10.1172/Jci95873 |
0.348 |
|
| 2018 |
Lavoie H, Sahmi M, Maisonneuve P, Marullo SA, Thevakumaran N, Jin T, Kurinov I, Sicheri F, Therrien M. MEK drives BRAF activation through allosteric control of KSR proteins. Nature. PMID 29433126 DOI: 10.1038/Nature25478 |
0.581 |
|
| 2018 |
Assadieskandar A, Yu C, Maisonneuve P, Liu X, Chen YC, Prakash GKS, Kurinov I, Sicheri F, Zhang C. Effects of rigidity on the selectivity of protein kinase inhibitors. European Journal of Medicinal Chemistry. 146: 519-528. PMID 29407977 DOI: 10.1016/J.Ejmech.2018.01.053 |
0.448 |
|
| 2017 |
Daou S, Sicheri F. Vivid views of the PINK1 protein. Nature. 552: 38-39. PMID 32080517 DOI: 10.1038/D41586-017-07691-X |
0.436 |
|
| 2017 |
Couzens AL, Xiong S, Knight JD, Mao DY, Guettler S, Picaud S, Kurinov I, Filippakopoulos P, Sicheri F, Gingras AC. MOB1 mediated phospho-recognition in the core mammalian Hippo pathway. Molecular & Cellular Proteomics : McP. PMID 28373298 DOI: 10.1074/Mcp.M116.065490 |
0.52 |
|
| 2017 |
Xiong S, Couzens AL, Kean MJ, Mao DY, Guettler S, Kurinov I, Gingras AC, Sicheri F. Regulation of protein interactions by MOB1 phosphorylation. Molecular & Cellular Proteomics : McP. PMID 28373297 DOI: 10.1074/Mcp.M117.068130 |
0.542 |
|
| 2017 |
Manczyk N, Yates BP, Veggiani G, Ernst A, Sicheri F, Sidhu SS. Structural and functional characterization of a ubiquitin variant engineered for tight and specific binding to an alpha-helical ubiquitin interacting motif. Protein Science : a Publication of the Protein Society. PMID 28276594 DOI: 10.1002/Pro.3155 |
0.439 |
|
| 2017 |
Keszei AF, Sicheri F. Mechanism of catalysis, E2 recognition, and autoinhibition for the IpaH family of bacterial E3 ubiquitin ligases. Proceedings of the National Academy of Sciences of the United States of America. PMID 28115697 DOI: 10.1073/Pnas.1611595114 |
0.45 |
|
| 2017 |
Csizmok V, Orlicky S, Cheng J, Song J, Bah A, Delgoshaie N, Lin H, Mittag T, Sicheri F, Chan HS, Tyers M, Forman-Kay JD. An allosteric conduit facilitates dynamic multisite substrate recognition by the SCF(Cdc4) ubiquitin ligase. Nature Communications. 8: 13943. PMID 28045046 DOI: 10.1038/Ncomms13943 |
0.465 |
|
| 2017 |
Sicheri F. Structural principles of protein kinase regulation Acta Crystallographica Section a Foundations and Advances. 73: a329-a329. DOI: 10.1107/S0108767317096787 |
0.392 |
|
| 2016 |
Wan LC, Maisonneuve P, Szilard RK, Lambert JP, Ng TF, Manczyk N, Huang H, Laister R, Caudy AA, Gingras AC, Durocher D, Sicheri F. Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7. Nucleic Acids Research. PMID 27903914 DOI: 10.1093/Nar/Gkw1181 |
0.368 |
|
| 2016 |
Spencer-Smith R, Koide A, Zhou Y, Eguchi RR, Sha F, Gajwani P, Santana D, Gupta A, Jacobs M, Herrero-Garcia E, Cobbert J, Lavoie H, Smith M, Rajakulendran T, Dowdell E, ... ... Sicheri F, et al. Inhibition of RAS function through targeting an allosteric regulatory site. Nature Chemical Biology. PMID 27820802 DOI: 10.1038/Nchembio.2231 |
0.742 |
|
| 2016 |
Wilson MD, Benlekbir S, Fradet-Turcotte A, Sherker A, Julien JP, McEwan A, Noordermeer SM, Sicheri F, Rubinstein JL, Durocher D. The structural basis of modified nucleosome recognition by 53BP1. Nature. PMID 27462807 DOI: 10.1038/Nature18951 |
0.327 |
|
| 2016 |
Wan LC, Pillon MC, Thevakumaran N, Sun Y, Chakrabartty A, Guarné A, Kurinov I, Durocher D, Sicheri F. Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis. Nucleic Acids Research. PMID 27302132 DOI: 10.1093/Nar/Gkw542 |
0.428 |
|
| 2016 |
Gorelik M, Orlicky S, Sartori MA, Tang X, Marcon E, Kurinov I, Greenblatt JF, Tyers M, Moffat J, Sicheri F, Sidhu SS. Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface. Proceedings of the National Academy of Sciences of the United States of America. PMID 26976582 DOI: 10.1073/Pnas.1519389113 |
0.419 |
|
| 2015 |
Zeqiraj E, Tian L, Piggott CA, Pillon MC, Duffy NM, Ceccarelli DF, Keszei AF, Lorenzen K, Kurinov I, Orlicky S, Gish GD, Heck AJ, Guarné A, Greenberg RA, Sicheri F. Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function. Molecular Cell. 59: 970-83. PMID 26344097 DOI: 10.1016/J.Molcel.2015.07.028 |
0.455 |
|
| 2015 |
Zeqiraj E, Sicheri F. Getting a handle on glycogen synthase - Its interaction with glycogenin. Molecular Aspects of Medicine. PMID 26278983 DOI: 10.1016/J.Mam.2015.08.004 |
0.302 |
|
| 2015 |
Li JJ, Cao C, Fixsen SM, Young JM, Ono C, Bando H, Elde NC, Katsuma S, Dever TE, Sicheri F. Baculovirus protein PK2 subverts eIF2α kinase function by mimicry of its kinase domain C-lobe. Proceedings of the National Academy of Sciences of the United States of America. 112: E4364-73. PMID 26216977 DOI: 10.1073/Pnas.1505481112 |
0.577 |
|
| 2015 |
Hunter RW, Zeqiraj E, Morrice N, Sicheri F, Sakamoto K. Expression and purification of functional human glycogen synthase-1:glycogenin-1 complex in insect cells. Protein Expression and Purification. 108: 23-9. PMID 25527037 DOI: 10.1016/J.Pep.2014.12.007 |
0.352 |
|
| 2015 |
Thevakumaran N, Lavoie H, Critton DA, Tebben A, Marinier A, Sicheri F, Therrien M. Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation. Nature Structural & Molecular Biology. 22: 37-43. PMID 25437913 DOI: 10.1038/Nsmb.2924 |
0.49 |
|
| 2015 |
Li JJ, Cao C, Fixsen SM, Young JM, Ono C, Bando H, Elde NC, Katsuma S, Dever TE, Sicheri F, Shokat KM. Baculovirus protein PK2 subverts eIF2α kinase function by mimicry of its kinase domain C-lobe Proceedings of the National Academy of Sciences of the United States of America. 112: E4364-E4373. DOI: 10.1073/pnas.1505481112 |
0.598 |
|
| 2014 |
Lavoie H, Li JJ, Thevakumaran N, Therrien M, Sicheri F. Dimerization-induced allostery in protein kinase regulation. Trends in Biochemical Sciences. 39: 475-86. PMID 25220378 DOI: 10.1016/J.Tibs.2014.08.004 |
0.526 |
|
| 2014 |
Sanches M, Duffy NM, Talukdar M, Thevakumaran N, Chiovitti D, Canny MD, Lee K, Kurinov I, Uehling D, Al-awar R, Poda G, Prakesch M, Wilson B, Tam V, Schweitzer C, ... ... Sicheri F, et al. Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors. Nature Communications. 5: 4202. PMID 25164867 DOI: 10.1038/Ncomms5202 |
0.439 |
|
| 2014 |
Zeqiraj E, Tang X, Hunter RW, García-Rocha M, Judd A, Deak M, von Wilamowitz-Moellendorff A, Kurinov I, Guinovart JJ, Tyers M, Sakamoto K, Sicheri F. Structural basis for the recruitment of glycogen synthase by glycogenin. Proceedings of the National Academy of Sciences of the United States of America. 111: E2831-40. PMID 24982189 DOI: 10.1073/Pnas.1402926111 |
0.409 |
|
| 2014 |
Wybenga-Groot LE, Ho CS, Sweeney FD, Ceccarelli DF, McGlade CJ, Durocher D, Sicheri F. Structural basis of Rad53 kinase activation by dimerization and activation segment exchange Cellular Signalling. 26: 1825-1836. PMID 24815189 DOI: 10.1016/J.Cellsig.2014.05.004 |
0.537 |
|
| 2014 |
Huang H, Zeqiraj E, Dong B, Jha BK, Duffy NM, Orlicky S, Thevakumaran N, Talukdar M, Pillon MC, Ceccarelli DF, Wan LC, Juang YC, Mao DY, Gaughan C, Brinton MA, ... ... Sicheri F, et al. Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity. Molecular Cell. 53: 221-34. PMID 24462203 DOI: 10.1016/J.Molcel.2013.12.025 |
0.416 |
|
| 2014 |
Huang H, Ceccarelli DF, Orlicky S, St-Cyr DJ, Ziemba A, Garg P, Plamondon S, Auer M, Sidhu S, Marinier A, Kleiger G, Tyers M, Sicheri F. E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin. Nature Chemical Biology. 10: 156-163. PMID 24316736 DOI: 10.1038/Nchembio.1412 |
0.412 |
|
| 2014 |
Keszei AF, Tang X, McCormick C, Zeqiraj E, Rohde JR, Tyers M, Sicheri F. Structure of an SspH1-PKN1 complex reveals the basis for host substrate recognition and mechanism of activation for a bacterial E3 ubiquitin ligase. Molecular and Cellular Biology. 34: 362-73. PMID 24248594 DOI: 10.1128/Mcb.01360-13 |
0.476 |
|
| 2013 |
Couzens AL, Knight JD, Kean MJ, Teo G, Weiss A, Dunham WH, Lin ZY, Bagshaw RD, Sicheri F, Pawson T, Wrana JL, Choi H, Gingras AC. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Science Signaling. 6: rs15. PMID 24255178 DOI: 10.1126/Scisignal.2004712 |
0.511 |
|
| 2013 |
Fradet-Turcotte A, Canny MD, Escribano-DÃaz C, Orthwein A, Leung CC, Huang H, Landry MC, Kitevski-LeBlanc J, Noordermeer SM, Sicheri F, Durocher D. 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark. Nature. 499: 50-4. PMID 23760478 DOI: 10.1038/Nature12318 |
0.339 |
|
| 2013 |
Rivkin E, Almeida SM, Ceccarelli DF, Juang YC, MacLean TA, Srikumar T, Huang H, Dunham WH, Fukumura R, Xie G, Gondo Y, Raught B, Gingras AC, Sicheri F, Cordes SP. The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis. Nature. 498: 318-24. PMID 23708998 DOI: 10.1038/Nature12296 |
0.393 |
|
| 2013 |
Lavoie H, Thevakumaran N, Gavory G, Li JJ, Padeganeh A, Guiral S, Duchaine J, Mao DY, Bouvier M, Sicheri F, Therrien M. Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization. Nature Chemical Biology. 9: 428-36. PMID 23685672 DOI: 10.1038/Nchembio.1257 |
0.542 |
|
| 2013 |
Wan LC, Mao DY, Neculai D, Strecker J, Chiovitti D, Kurinov I, Poda G, Thevakumaran N, Yuan F, Szilard RK, Lissina E, Nislow C, Caudy AA, Durocher D, Sicheri F. Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system. Nucleic Acids Research. 41: 6332-46. PMID 23620299 DOI: 10.1093/Nar/Gkt322 |
0.701 |
|
| 2013 |
Ernst A, Avvakumov G, Tong J, Fan Y, Zhao Y, Alberts P, Persaud A, Walker JR, Neculai AM, Neculai D, Vorobyov A, Garg P, Beatty L, Chan PK, Juang YC, ... ... Sicheri F, et al. A strategy for modulation of enzymes in the ubiquitin system. Science (New York, N.Y.). 339: 590-5. PMID 23287719 DOI: 10.1126/Science.1230161 |
0.715 |
|
| 2013 |
Rivkin E, Almeida SM, Ceccarelli DF, Juang Y-, MacLean TA, Srikumar T, Huang H, Dunham W, Fukumura R, Xie G, Gondo Y, Raught B, Gingras A-, Sicheri F, Cordes S. The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesisThe linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis Nature. DOI: 10.2210/Pdb4Ksj/Pdb |
0.308 |
|
| 2012 |
Shehata SN, Hunter RW, Ohta E, Peggie MW, Lou HJ, Sicheri F, Zeqiraj E, Turk BE, Sakamoto K. Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase Cellular Signalling. 24: 2085-2094. PMID 22796189 DOI: 10.1016/j.cellsig.2012.06.018 |
0.419 |
|
| 2012 |
Tang X, Orlicky S, Mittag T, Csizmok V, Pawson T, Forman-Kay JD, Sicheri F, Tyers M. Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCF Cdc4 ubiquitin ligase Proceedings of the National Academy of Sciences of the United States of America. 109: 3287-3292. PMID 22328159 DOI: 10.1073/Pnas.1116455109 |
0.476 |
|
| 2012 |
Juang YC, Landry MC, Sanches M, Vittal V, Leung CC, Ceccarelli DF, Mateo AR, Pruneda JN, Mao DY, Szilard RK, Orlicky S, Munro M, Brzovic PS, Klevit RE, Sicheri F, et al. OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function. Molecular Cell. 45: 384-97. PMID 22325355 DOI: 10.1016/J.Molcel.2012.01.011 |
0.349 |
|
| 2012 |
Liu J, Fairn GD, Ceccarelli DF, Sicheri F, Wilde A. Cleavage furrow organization requires PIP 2-mediated recruitment of anillin Current Biology. 22: 64-69. PMID 22197245 DOI: 10.1016/J.Cub.2011.11.040 |
0.352 |
|
| 2012 |
Chou YC, Keszei AFA, Rohde JR, Tyers M, Sicheri F. Conserved structural mechanisms for autoinhibition in IpaH ubiquitin ligases Journal of Biological Chemistry. 287: 268-275. PMID 22065585 DOI: 10.1074/Jbc.M111.316265 |
0.611 |
|
| 2012 |
Ogunjimi AA, Zeqiraj E, Ceccarelli DF, Sicheri F, Wrana JL, David L. Structural basis for specificity of TGFβ family receptor small molecule inhibitors Cellular Signalling. 24: 476-483. PMID 21983015 DOI: 10.1016/J.Cellsig.2011.09.027 |
0.433 |
|
| 2011 |
Guettler S, LaRose J, Petsalaki E, Gish G, Scotter A, Pawson T, Rottapel R, Sicheri F. Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease. Cell. 147: 1340-54. PMID 22153077 DOI: 10.1016/J.Cell.2011.10.046 |
0.407 |
|
| 2011 |
Persaud A, Alberts P, Hayes M, Guettler S, Clarke I, Sicheri F, Dirks P, Ciruna B, Rotin D. Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function. The Embo Journal. 30: 3259-73. PMID 21765395 DOI: 10.1038/Emboj.2011.234 |
0.414 |
|
| 2011 |
Ceccarelli DF, Tang X, Pelletier B, Orlicky S, Xie W, Plantevin V, Neculai D, Chou YC, Ogunjimi A, Al-Hakim A, Varelas X, Koszela J, Wasney GA, Vedadi M, Dhe-Paganon S, ... ... Sicheri F, et al. An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. Cell. 145: 1075-87. PMID 21683433 DOI: 10.1016/J.Cell.2011.05.039 |
0.744 |
|
| 2011 |
Ceccarelli DF, Laister RC, Mulligan VK, Kean MJ, Goudreault M, Scott IC, Derry WB, Chakrabartty A, Gingras AC, Sicheri F. CCM3/PDCD10 heterodimerizes with germinal center kinase III (GCKIII) proteins using a mechanism analogous to CCM3 homodimerization. The Journal of Biological Chemistry. 286: 25056-64. PMID 21561863 DOI: 10.1074/Jbc.M110.213777 |
0.531 |
|
| 2011 |
Kean MJ, Ceccarelli DF, Goudreault M, Sanches M, Tate S, Larsen B, Gibson LC, Derry WB, Scott IC, Pelletier L, Baillie GS, Sicheri F, Gingras AC. Structure-function analysis of core STRIPAK Proteins: a signaling complex implicated in Golgi polarization. The Journal of Biological Chemistry. 286: 25065-75. PMID 21561862 DOI: 10.1074/Jbc.M110.214486 |
0.491 |
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| 2011 |
Dey M, Velyvis A, Li JJ, Chiu E, Chiovitti D, Kay LE, Sicheri F, Dever TE. Requirement for kinase-induced conformational change in eukaryotic initiation factor 2alpha (eIF2alpha) restricts phosphorylation of Ser51. Proceedings of the National Academy of Sciences of the United States of America. 108: 4316-21. PMID 21368187 DOI: 10.1073/Pnas.1014872108 |
0.515 |
|
| 2011 |
Volkmann K, Lucas JL, Vuga D, Wang X, Brumm D, Stiles C, Kriebel D, Der-Sarkissian A, Krishnan K, Schweitzer C, Liu Z, Malyankar UM, Chiovitti D, Canny M, Durocher D, ... Sicheri F, et al. Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease Journal of Biological Chemistry. 286: 12743-12755. PMID 21303903 DOI: 10.1074/Jbc.M110.199737 |
0.406 |
|
| 2011 |
Lee KPK, Sicheri F. Principles of IRE1 modulation using chemical tools Methods in Enzymology. 490: 271-294. PMID 21266256 DOI: 10.1016/B978-0-12-385114-7.00016-7 |
0.315 |
|
| 2011 |
Liu Q, Larsen B, Ricicova M, Orlicky S, Tekotte H, Tang X, Craig K, Quiring A, Le Bihan T, Hansen C, Sicheri F, Tyers M. SCFCdc4 enables mating type switching in yeast by cyclin-dependent kinase-mediated elimination of the Ash1 transcriptional repressor Molecular and Cellular Biology. 31: 584-598. PMID 21098119 DOI: 10.1128/Mcb.00845-10 |
0.477 |
|
| 2011 |
Udell CM, Rajakulendran T, Sicheri F, Therrien M. Mechanistic principles of RAF kinase signaling. Cellular and Molecular Life Sciences : Cmls. 68: 553-65. PMID 20820846 DOI: 10.1007/S00018-010-0520-6 |
0.823 |
|
| 2011 |
Mittag T, Orlicky S, Tang X, Sicheri F, Tyers M, Forman-Kay JD. The Role of Dynamic Protein Complexes in the Ubiquitin-Proteasome Pathway Biophysical Journal. 100: 518a-519a. DOI: 10.1016/J.Bpj.2010.12.3032 |
0.462 |
|
| 2010 |
Nakada S, Tai I, Panier S, Al-Hakim A, Iemura SI, Juang YC, O'Donnell L, Kumakubo A, Munro M, Sicheri F, Gingras AC, Natsume T, Suda T, Durocher D. Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1 Nature. 466: 941-946. PMID 20725033 DOI: 10.1038/Nature09297 |
0.385 |
|
| 2010 |
Youn JY, Friesen H, Kishimoto T, Henne WM, Kurat CF, Ye W, Ceccarelli DF, Sicheri F, Kohlwein SD, McMahon HT, Andrews BJ. Dissecting BAR domain function in the yeast Amphiphysins Rvs161 and Rvs167 during endocytosis. Molecular Biology of the Cell. 21: 3054-69. PMID 20610658 DOI: 10.1091/Mbc.E10-03-0181 |
0.427 |
|
| 2010 |
Orlicky S, Tang X, Neduva V, Elowe N, Brown ED, Sicheri F, Tyers M. An allosteric inhibitor of substrate recognition by the SCF Cdc4 ubiquitin ligase Nature Biotechnology. 28: 733-737. PMID 20581844 DOI: 10.1038/Nbt.1646 |
0.496 |
|
| 2010 |
Wiseman RL, Zhang Y, Lee KP, Harding HP, Haynes CM, Price J, Sicheri F, Ron D. Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Molecular Cell. 38: 291-304. PMID 20417606 DOI: 10.1016/J.Molcel.2010.04.001 |
0.476 |
|
| 2010 |
Mittag T, Marsh J, Grishaev A, Orlicky S, Lin H, Sicheri F, Tyers M, Forman-Kay JD. Structure/Function Implications in a Dynamic Complex of the Intrinsically Disordered Sic1 with the Cdc4 Subunit of an SCF Ubiquitin Ligase Structure. 18: 494-506. PMID 20399186 DOI: 10.1016/J.Str.2010.01.020 |
0.432 |
|
| 2010 |
Rajakulendran T, Sicheri F. Allosteric Protein kinase regulation by pseudokinases: Insights from STRAD Science Signaling. 3: pe8. PMID 20197543 DOI: 10.1126/Scisignal.3111Pe8 |
0.815 |
|
| 2010 |
Ogunjimi AA, Wiesner S, Briant DJ, Varelas X, Sicheri F, Forman-Kay J, Wrana JL. The ubiquitin binding region of the Smurf HECT domain facilitates polyubiquitylation and binding of ubiquitylated substrates. The Journal of Biological Chemistry. 285: 6308-15. PMID 20026602 DOI: 10.1074/Jbc.M109.044537 |
0.473 |
|
| 2010 |
Mittag T, Choy W, Marsh J, Orlicky S, Grishaev A, Lin H, Sicheri F, Tyers M, Forman-Kay J. Assignment and structural characterization of intrinsically disordered CDK inhibitor phosphoSic1 from yeast Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr16657 |
0.312 |
|
| 2009 |
Rajakulendran T, Sahmi M, Lefrançois M, Sicheri F, Therrien M. A dimerization-dependent mechanism drives RAF catalytic activation. Nature. 461: 542-5. PMID 19727074 DOI: 10.1038/Nature08314 |
0.812 |
|
| 2009 |
Murphy JM, Hansen DF, Wiesner S, Muhandiram DR, Borg M, Smith MJ, Sicheri F, Kay LE, Forman-Kay JD, Pawson T. Structural studies of FF domains of the transcription factor CA150 provide insights into the organization of FF domain tandem arrays. Journal of Molecular Biology. 393: 409-24. PMID 19715701 DOI: 10.1016/J.Jmb.2009.08.049 |
0.423 |
|
| 2009 |
Ceccarelli DFJ, Sicheri F. Grb-ing hold of insulin signaling Nature Structural and Molecular Biology. 16: 803-804. PMID 19654617 DOI: 10.1038/Nsmb0809-803 |
0.303 |
|
| 2009 |
Leung GC, Murphy JM, Briant D, Sicheri F. Characterization of kinase target phosphorylation consensus motifs using peptide SPOT arrays. Methods in Molecular Biology (Clifton, N.J.). 570: 187-95. PMID 19649593 DOI: 10.1007/978-1-60327-394-7_7 |
0.407 |
|
| 2009 |
Meyer-Schaller N, Chou YC, Sumara I, Martin DDO, Kurz T, Katheder N, Hofmann K, Berthiaume LG, Sicheri F, Peter M. The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes Proceedings of the National Academy of Sciences of the United States of America. 106: 12365-12370. PMID 19617556 DOI: 10.1073/Pnas.0812528106 |
0.617 |
|
| 2009 |
Dev K, Santangelo TJ, Rothenburg S, Neculai D, Dey M, Sicheri F, Dever TE, Reeve JN, Hinnebusch AG. Archaeal aIF2B Interacts with Eukaryotic Translation Initiation Factors eIF2α and eIF2Bα: Implications for aIF2B Function and eIF2B Regulation Journal of Molecular Biology. 392: 701-722. PMID 19616556 DOI: 10.1016/J.Jmb.2009.07.030 |
0.722 |
|
| 2009 |
Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Molecular & Cellular Proteomics : McP. 8: 157-71. PMID 18782753 DOI: 10.1074/Mcp.M800266-Mcp200 |
0.47 |
|
| 2008 |
Mittag T, Orlicky S, Choy WY, Tang X, Lin H, Sicheri F, Kay LE, Tyers M, Forman-Kay JD. Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor. Proceedings of the National Academy of Sciences of the United States of America. 105: 17772-7. PMID 19008353 DOI: 10.1073/Pnas.0809222105 |
0.399 |
|
| 2008 |
Seo EJ, Liu F, Kawagishi-Kobayashi M, Ung TL, Cao C, Dar AC, Sicheri F, Dever TE. Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein. Proceedings of the National Academy of Sciences of the United States of America. 105: 16894-9. PMID 18971339 DOI: 10.1073/Pnas.0805524105 |
0.784 |
|
| 2008 |
Mao DY, Neculai D, Downey M, Orlicky S, Haffani YZ, Ceccarelli DF, Ho JS, Szilard RK, Zhang W, Ho CS, Wan L, Fares C, Rumpel S, Kurinov I, Arrowsmith CH, ... ... Sicheri F, et al. Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine. Molecular Cell. 32: 259-75. PMID 18951093 DOI: 10.1016/J.Molcel.2008.10.002 |
0.765 |
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| 2008 |
Mao DY, Ceccarelli DF, Sicheri F. "Unraveling the tail" of how SRPK1 phosphorylates ASF/SF2. Molecular Cell. 29: 535-7. PMID 18342599 DOI: 10.1016/J.Molcel.2008.02.009 |
0.44 |
|
| 2008 |
Rajakulendran T, Sahmi M, Kurinov I, Tyers M, Therrien M, Sicheri F. CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling. Proceedings of the National Academy of Sciences of the United States of America. 105: 2836-41. PMID 18287031 DOI: 10.1073/Pnas.0709705105 |
0.823 |
|
| 2008 |
Kurz T, Chou YC, Willems AR, Meyer-Schaller N, Hecht ML, Tyers M, Peter M, Sicheri F. Dcn1 Functions as a Scaffold-Type E3 Ligase for Cullin Neddylation Molecular Cell. 29: 23-35. PMID 18206966 DOI: 10.1016/J.Molcel.2007.12.012 |
0.646 |
|
| 2008 |
Lee KPK, Dey M, Neculai D, Cao C, Dever TE, Sicheri F. Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing Cell. 132: 89-100. PMID 18191223 DOI: 10.1016/J.Cell.2007.10.057 |
0.779 |
|
| 2007 |
Weerasekera R, She YM, Markham KA, Bai Y, Opalka N, Orlicky S, Sicheri F, Kislinger T, Schmitt-Ulms G. Interactome and interface protocol (2IP): a novel strategy for high sensitivity topology mapping of protein complexes. Proteomics. 7: 3835-52. PMID 17960736 DOI: 10.1002/Pmic.200700688 |
0.327 |
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| 2007 |
Murphy JM, Korzhnev DM, Ceccarelli DF, Briant DJ, Zarrine-Afsar A, Sicheri F, Kay LE, Pawson T. Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain. Proceedings of the National Academy of Sciences of the United States of America. 104: 14336-41. PMID 17726107 DOI: 10.1073/Pnas.0703012104 |
0.52 |
|
| 2007 |
Wiesner S, Ogunjimi AA, Wang HR, Rotin D, Sicheri F, Wrana JL, Forman-Kay JD. Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. Cell. 130: 651-62. PMID 17719543 DOI: 10.1016/J.Cell.2007.06.050 |
0.465 |
|
| 2007 |
Tang X, Orlicky S, Lin Z, Willems A, Neculai D, Ceccarelli D, Mercurio F, Shilton BH, Sicheri F, Tyers M. Suprafacial Orientation of the SCFCdc4 Dimer Accommodates Multiple Geometries for Substrate Ubiquitination Cell. 129: 1165-1176. PMID 17574027 DOI: 10.1016/J.Cell.2007.04.042 |
0.738 |
|
| 2007 |
Ceccarelli DFJ, Blasutig IM, Goudreault M, Li Z, Ruston J, Pawson T, Sicheri F. Non-canonical interaction of phosphoinositides with pleckstrin homology domains of Tiam1 and ArhGAP9 Journal of Biological Chemistry. 282: 13864-13874. PMID 17339315 DOI: 10.1074/Jbc.M700505200 |
0.425 |
|
| 2007 |
Dey M, Cao C, Sicheri F, Dever TE. Conserved intermolecular salt bridge required for activation of protein kinases PKR, GCN2, and PERK Journal of Biological Chemistry. 282: 6653-6660. PMID 17202131 DOI: 10.1074/Jbc.M607897200 |
0.564 |
|
| 2007 |
Leung GC, Ho CS, Blasutig IM, Murphy JM, Sicheri F. Determination of the Plk4/Sak consensus phosphorylation motif using peptide spots arrays. Febs Letters. 581: 77-83. PMID 17174311 DOI: 10.1016/J.Febslet.2006.11.080 |
0.514 |
|
| 2007 |
Wiesner S, Ogunjimi A, Wang H, Rotin D, Sicheri F, Wrana J, Forman-Kay J. Solution Structure of the C2 domain of human Smurf2 Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr15306 |
0.324 |
|
| 2007 |
Dever TE, Dar AC, Sicheri F. 12 The eIF2α Kinases Cold Spring Harbor Monograph Archive. 48: 319-344. DOI: 10.1101/087969767.48.319 |
0.771 |
|
| 2006 |
Wiesner S, Wybenga-Groot LE, Warner N, Lin H, Pawson T, Forman-Kay JD, Sicheri F. A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases. The Embo Journal. 25: 4686-96. PMID 16977320 DOI: 10.1038/Sj.Emboj.7601315 |
0.456 |
|
| 2006 |
Mrkobrada S, Boucher L, Ceccarelli DF, Tyers M, Sicheri F. Structural and functional analysis of Saccharomyces cerevisiae Mob1. Journal of Molecular Biology. 362: 430-40. PMID 16934835 DOI: 10.1016/J.Jmb.2006.07.007 |
0.461 |
|
| 2006 |
Briant DJ, Ceccarelli DF, Sicheri F. I Siah Substrate! Structure. 14: 627-628. PMID 16615900 DOI: 10.1016/J.Str.2006.03.003 |
0.345 |
|
| 2006 |
Aviv T, Lin Z, Ben-Ari G, Smibert CA, Sicheri F. Sequence-specific recognition of RNA hairpins by the SAM domain of Vts1p Nature Structural and Molecular Biology. 13: 168-176. PMID 16429151 DOI: 10.1038/Nsmb1053 |
0.402 |
|
| 2006 |
Aviv T, Amborski AN, Zhao XS, Kwan JJ, Johnson PE, Sicheri F, Donaldson LW. The NMR and X-ray structures of the Saccharomyces cerevisiae Vts1 SAM domain define a surface for the recognition of RNA hairpins. Journal of Molecular Biology. 356: 274-9. PMID 16375924 DOI: 10.1016/J.Jmb.2005.11.066 |
0.379 |
|
| 2005 |
Tang X, Orlicky S, Liu Q, Willems A, Sicheri F, Tyers M. Genome-wide surveys for phosphorylation-dependent substrates of SCF ubiquitin ligases Methods in Enzymology. 399: 433-458. PMID 16338374 DOI: 10.1016/S0076-6879(05)99030-7 |
0.494 |
|
| 2005 |
Dey M, Cao C, Dar AC, Tamura T, Ozato K, Sicheri F, Dever TE. Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition. Cell. 122: 901-13. PMID 16179259 DOI: 10.1016/J.Cell.2005.06.041 |
0.788 |
|
| 2005 |
Dar AC, Dever TE, Sicheri F. Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR. Cell. 122: 887-900. PMID 16179258 DOI: 10.1016/J.Cell.2005.06.044 |
0.785 |
|
| 2005 |
Ogunjimi AA, Briant DJ, Pece-Barbara N, Le Roy C, Di Guglielmo GM, Kavsak P, Rasmussen RK, Seet BT, Sicheri F, Wrana JL. Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain Molecular Cell. 19: 297-308. PMID 16061177 DOI: 10.1016/J.Molcel.2005.06.028 |
0.458 |
|
| 2005 |
Dey M, Trieselmann B, Locke EG, Lu J, Cao C, Dar AC, Krishnamoorthy T, Dong J, Sicheri F, Dever TE. PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2alpha. Molecular and Cellular Biology. 25: 3063-75. PMID 15798194 DOI: 10.1128/Mcb.25.8.3063-3075.2005 |
0.774 |
|
| 2003 |
Hoang QQ, Sicheri F, Howard AJ, Yang DSC. Bone recognition mechanism of porcine osteocalcin from crystal structure Nature. 425: 977-980. PMID 14586470 DOI: 10.1038/Nature02079 |
0.651 |
|
| 2003 |
Zigmond SH, Evangelista M, Boone C, Yang C, Dar AC, Sicheri F, Forkey J, Pring M. Formin leaky cap allows elongation in the presence of tight capping proteins. Current Biology : Cb. 13: 1820-3. PMID 14561409 DOI: 10.1016/J.Cub.2003.09.057 |
0.698 |
|
| 2003 |
Leung GC, Sicheri F. A polo match for Plk1 Cell. 115: 3-4. PMID 14531994 DOI: 10.1016/S0092-8674(03)00761-X |
0.508 |
|
| 2003 |
Aviv T, Lin Z, Lau S, Rendl LM, Sicheri F, Smibert CA. The RNA-binding SAM domain of Smaug defines a new family of post-transcriptional regulators Nature Structural Biology. 10: 614-621. PMID 12858164 DOI: 10.1038/Nsb956 |
0.433 |
|
| 2003 |
Orlicky S, Tang X, Willems A, Tyers M, Sicheri F. Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase Cell. 112: 243-256. PMID 12553912 DOI: 10.1016/S0092-8674(03)00034-5 |
0.501 |
|
| 2002 |
Leung GC, Hudson JW, Kozarova A, Davidson A, Dennis JW, Sicheri F. The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization Nature Structural Biology. 9: 719-724. PMID 12352953 DOI: 10.1038/Nsb848 |
0.55 |
|
| 2002 |
Dar AC, Sicheri F. X-ray crystal structure and functional analysis of vaccinia virus K3L reveals molecular determinants for PKR subversion and substrate recognition. Molecular Cell. 10: 295-305. PMID 12191475 DOI: 10.1016/S1097-2765(02)00590-7 |
0.747 |
|
| 2001 |
Nash P, Tang X, Orlicky S, Chen Q, Gertler FB, Mendenhall MD, Sicheri F, Pawson T, Tyers M. Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature. 414: 514-21. PMID 11734846 DOI: 10.1038/35107009 |
0.501 |
|
| 2001 |
Luo Y, Bertero MG, Frey EA, Pfuetzner RA, Wenk MR, Creagh L, Marcus SL, Lim D, Sicheri F, Kay C, Haynes C, Finlay BB, Strynadka NC. Structural and biochemical characterization of the type III secretion chaperones CesT and SigE. Nature Structural Biology. 8: 1031-6. PMID 11685226 DOI: 10.1038/Nsb717 |
0.395 |
|
| 2001 |
Wybenga-Groot LE, Baskin B, Ong SH, Tong J, Pawson T, Sicheri F. Structural basis for autoinhibition of the EphB2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region Cell. 106: 745-757. PMID 11572780 DOI: 10.1016/S0092-8674(01)00496-2 |
0.525 |
|
| 2000 |
Binns KL, Taylor PP, Sicheri F, Pawson T, Holland SJ. Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors Molecular and Cellular Biology. 20: 4791-4805. PMID 10848605 DOI: 10.1128/Mcb.20.13.4791-4805.2000 |
0.512 |
|
| 1999 |
Schindler T, Sicheri F, Pico A, Gazit A, Levitzki A, Kuriyan J. Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor Molecular Cell. 3: 639-648. PMID 10360180 DOI: 10.1016/S1097-2765(00)80357-3 |
0.682 |
|
| 1999 |
Stapleton D, Balan I, Pawson T, Sicheri F. The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization Nature Structural Biology. 6: 44-49. PMID 9886291 DOI: 10.1038/4917 |
0.549 |
|
| 1999 |
Lafevre-Bernt M, Sicheri F, Pico A, Porter M, Kuriyan J, Todd Miller W. Intramolecular regulatory interactions in the Src family kinase Hck probed by mutagenesis of a conserved tryptophan residue Journal of Biological Chemistry. 273: 32129-32134. PMID 9822689 DOI: 10.1074/Jbc.273.48.32129 |
0.633 |
|
| 1998 |
Yang DSC, Hon WC, Bubanko S, Xue Y, Seetharaman J, Hew CL, Sicheri F. Identification of the ice-binding surface on a type III antifreeze protein with a 'flatness function' algorithm Biophysical Journal. 74: 2142-2151. PMID 9591641 DOI: 10.1016/S0006-3495(98)77923-8 |
0.304 |
|
| 1997 |
Sicheri F, Kuriyan J. Structures of Src-family tyrosine kinases Current Opinion in Structural Biology. 7: 777-785. PMID 9434895 DOI: 10.1016/S0959-440X(97)80146-7 |
0.672 |
|
| 1997 |
Asante-Appiah E, Seetharaman J, Sicheri F, Yang DSC, Chan WWC. gem-Dialkyl succinic acids: A novel class of inhibitors for carboxypeptidases Biochemistry. 36: 8710-8715. PMID 9220957 DOI: 10.1021/Bi970354B |
0.36 |
|
| 1997 |
Moarefi I, LaFevre-Bernt M, Sicheri F, Huse M, Lee CH, Kuriyan J, Miller WT. Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement Nature. 385: 650-653. PMID 9024665 DOI: 10.1038/385650A0 |
0.807 |
|
| 1997 |
Sicheri F, Moarefi I, Kuriyan J. Crystal structure of the Src family tyrosine kinase Hck Nature. 385: 602-609. PMID 9024658 DOI: 10.1038/385602A0 |
0.698 |
|
| 1997 |
Kuriyan J, Moarefi L, Sicheri F, Lee CH, Huse M. Structure and regulation of sre-family tyrosine kinases Faseb Journal. 11: A875. |
0.575 |
|
| 1996 |
Sicheri F, Yang DS. Structure determination of a lone alpha-helical antifreeze protein from winter flounder. Acta Crystallographica. Section D, Biological Crystallography. 52: 486-98. PMID 15299670 DOI: 10.1107/S0907444995015253 |
0.446 |
|
| 1995 |
Sicheri F, Yang DSC. Ice-binding structure and mechanism of an antifreeze protein from winter flounder Nature. 375: 427-431. PMID 7760940 DOI: 10.1038/375427A0 |
0.341 |
|
| 1992 |
Sicheri FV, Derry WB, Gupta RS, Yang DS‐. Structure of 5‐(2‐hydroxyethoxy)‐6‐[1‐(4‐methoxyphenyl)ethyl]‐1,3‐benzodioxole Acta Crystallographica Section C. 48: 1687-1689. DOI: 10.1107/S0108270192001197 |
0.403 |
|
| 1992 |
Sicheri FV, Derry WB, Gupta RS, Yang DS‐. Structure of 4'‐demethylepipodophyllotoxin Acta Crystallographica Section C. 48: 747-749. DOI: 10.1107/S0108270191010740 |
0.402 |
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