| Year |
Citation |
Score |
| 2024 |
Fluegel LL, Deng MR, Su P, Kalkreuter E, Yang D, Rudolf JD, Dong LB, Shen B. Development of platensimycin, platencin, and platensilin overproducers by biosynthetic pathway engineering and fermentation medium optimization. Journal of Industrial Microbiology & Biotechnology. PMID 38262768 DOI: 10.1093/jimb/kuae003 |
0.666 |
|
| 2023 |
Bhardwaj M, Cui Z, Daniel Hankore E, Moonschi FH, Saghaeiannejad Esfahani H, Kalkreuter E, Gui C, Yang D, Phillips GN, Thorson JS, Shen B, Van Lanen SG. A discrete intermediate for the biosynthesis of both the enediyne core and the anthraquinone moiety of enediyne natural products. Proceedings of the National Academy of Sciences of the United States of America. 120: e2220468120. PMID 36802426 DOI: 10.1073/pnas.2220468120 |
0.597 |
|
| 2021 |
Meng S, Steele AD, Yan W, Pan G, Kalkreuter E, Liu YC, Xu Z, Shen B. Thiocysteine lyases as polyketide synthase domains installing hydropersulfide into natural products and a hydropersulfide methyltransferase. Nature Communications. 12: 5672. PMID 34584078 DOI: 10.1038/s41467-021-25798-8 |
0.636 |
|
| 2021 |
Luo J, Yang D, Hindra, Adhikari A, Dong LB, Ye F, Yan X, Rader C, Shen B. Discovery of ammosesters by mining the Streptomyces uncialis DCA2648 genome revealing new insight into ammosamide biosynthesis. Journal of Industrial Microbiology & Biotechnology. PMID 33982054 DOI: 10.1093/jimb/kuab027 |
0.305 |
|
| 2021 |
Cao M, Zheng C, Yang D, Kalkreuter E, Adhikari A, Liu YC, Rateb ME, Shen B. Cryptic sulfur incorporation in thioangucycline biosynthesis. Angewandte Chemie (International Ed. in English). PMID 33465268 DOI: 10.1002/anie.202015570 |
0.304 |
|
| 2020 |
Zheng CJ, Kalkreuter E, Fan BY, Liu YC, Dong LB, Shen B. PtmC Catalyzes the Final Step of Thioplatensimycin, Thioplatencin, and Thioplatensilin Biosynthesis and Expands the Scope of Arylamine -Acetyltransferases. Acs Chemical Biology. PMID 33314918 DOI: 10.1021/acschembio.0c00773 |
0.335 |
|
| 2020 |
Lohman JR, Shen B. The LnmK Bifunctional Acyltransferase/Decarboxylase Specifying (2)-Methylmalonyl-CoA and Employing Substrate-Assisted Catalysis for Polyketide Biosynthesis. Biochemistry. PMID 33095002 DOI: 10.1021/acs.biochem.0c00749 |
0.687 |
|
| 2020 |
Zhang X, King-Smith E, Dong LB, Yang LC, Rudolf JD, Shen B, Renata H. Divergent synthesis of complex diterpenes through a hybrid oxidative approach. Science (New York, N.Y.). 369: 799-806. PMID 32792393 DOI: 10.1126/Science.Abb8271 |
0.632 |
|
| 2020 |
Adhikari A, Teijaro C, Yan X, Chang CY, Gui C, Liu YC, Crnovcic I, Yang D, Annaval T, Rader C, Shen B. Characterization of TnmH as an O-Methyltransferase Revealing In-sights into Tiancimycin Biosynthesis and Enabling a Biocatalytic Strategy to Prepare Antibody-Tiancimycin Conjugates. Journal of Medicinal Chemistry. PMID 32658465 DOI: 10.1021/Acs.Jmedchem.0C00799 |
0.322 |
|
| 2020 |
Zhou W, Liang H, Qin X, Cao D, Zhu X, Ju J, Shen B, Duan Y, Huang Y. The Isolation of Pyrroloformamide Congeners and Characterization of Their Biosynthetic Gene Cluster. Journal of Natural Products. PMID 32049520 DOI: 10.1021/Acs.Jnatprod.9B00321 |
0.451 |
|
| 2019 |
Kalkreuter E, Pan G, Cepeda AJ, Shen B. Targeting Bacterial Genomes for Natural Product Discovery. Trends in Pharmacological Sciences. PMID 31822352 DOI: 10.1016/J.Tips.2019.11.002 |
0.671 |
|
| 2019 |
Steele AD, Teijaro CN, Yang D, Shen B. Leveraging a Large Microbial Strain Collection for Natural Product Discovery. The Journal of Biological Chemistry. PMID 31570525 DOI: 10.1074/Jbc.Rev119.006514 |
0.373 |
|
| 2019 |
Liang H, Jiang L, Jiang Q, Shi J, Xiang J, Yan X, Zhu X, Zhao L, Shen B, Duan Y, Huang Y. A 3-hydroxy-3-methylglutaryl-CoA synthase-based probe for the discovery of the acyltransferase-less type I polyketide synthases. Environmental Microbiology. PMID 31435987 DOI: 10.1111/1462-2920.14787 |
0.351 |
|
| 2019 |
Dong LB, Liu YC, Cepeda AJ, Kalkreuter E, Deng MR, Rudolf JD, Chang C, Joachimiak A, Phillips GN, Shen B. Characterization and Crystal Structure of a Nonheme Diiron Monooxygenase Involved in Platensimycin and Platencin Biosynthesis. Journal of the American Chemical Society. PMID 31291107 DOI: 10.1021/jacs.9b06183 |
0.715 |
|
| 2019 |
Su M, Qiu L, Deng Y, Ruiz CH, Rudolf JD, Dong LB, Feng X, Cameron MD, Shen B, Duan Y, Huang Y. Evaluation of Platensimycin and Platensimycin-Inspired Thioether Analogues against Methicillin-Resistant Staphylococcus aureus in Topical and Systemic Infection Mouse Models. Molecular Pharmaceutics. PMID 31244223 DOI: 10.1021/Acs.Molpharmaceut.9B00293 |
0.653 |
|
| 2019 |
Dong LB, Zhang X, Shen B, Rudolf JD, Deng MR, Kalkreuter E, Cepeda AJ, Renata H. Cryptic and Stereospecific Hydroxylation, Oxidation, and Reduction in Platensimycin and Platencin Biosynthesis. Journal of the American Chemical Society. PMID 30735041 DOI: 10.1021/Jacs.8B13452 |
0.696 |
|
| 2018 |
Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, ... ... Shen B, et al. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. Acs Central Science. 4: 1727-1741. PMID 30648156 DOI: 10.1021/Acscentsci.8B00747 |
0.34 |
|
| 2018 |
Xu Z, Pan G, Zhou H, Shen B. Discovery and Characterization of 1-Aminocyclopropane-1-carboxylic Acid Synthase of Bacterial Origin. Journal of the American Chemical Society. PMID 30472830 DOI: 10.1021/Jacs.8B11463 |
0.699 |
|
| 2018 |
McAlpine JB, Chen SN, Kutateladze A, MacMillan JB, Appendino G, Barison A, Beniddir MA, Biavatti MW, Bluml S, Boufridi A, Butler MS, Capon RJ, Choi YH, Coppage D, Crews P, ... ... Shen B, et al. Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Natural Product Reports. PMID 30468235 DOI: 10.1039/c8np90041h |
0.654 |
|
| 2018 |
Deng Y, Su M, Kang D, Liu X, Wen Z, Li Y, Qiu L, Shen B, Duan Y, Huang Y. Semisynthesis of Platensimycin Derivatives with Antibiotic Activities in Mice via Suzuki-Miyaura Cross-Coupling Reactions. Journal of Medicinal Chemistry. PMID 30461269 DOI: 10.1021/Acs.Jmedchem.8B01580 |
0.308 |
|
| 2018 |
Teijaro CN, Adhikari A, Shen B. Challenges and opportunities for natural product discovery, production, and engineering in native producers versus heterologous hosts. Journal of Industrial Microbiology & Biotechnology. PMID 30426283 DOI: 10.1007/S10295-018-2094-5 |
0.41 |
|
| 2018 |
Rudolf JD, Dong LB, Zhang X, Renata H, Shen B. Cytochrome P450-Catalyzed Hydroxylation Initiating Ether Formation in Platensimycin Biosynthesis. Journal of the American Chemical Society. PMID 30216060 DOI: 10.1021/Jacs.8B08012 |
0.693 |
|
| 2018 |
Yan X, Chen JJ, Adhikari A, Teijaro CN, Ge H, Crnovcic I, Chang CY, Annaval T, Yang D, Rader C, Shen B. Comparative Studies of the Biosynthetic Gene Clusters for Anthraquinone-Fused Enediynes Shedding Light into the Tailoring Steps of Tiancimycin Biosynthesis. Organic Letters. PMID 30212211 DOI: 10.1021/Acs.Orglett.8B02584 |
0.388 |
|
| 2018 |
Annaval T, Han L, Rudolf JD, Xie G, Yang D, Chang CY, Ma M, Crnovcic I, Miller MD, Soman J, Xu W, Phillips GN, Shen B. Biochemical and structural characterization of TtnD, a prenylated FMN-dependent decarboxylase from the tautomycetin biosynthetic pathway. Acs Chemical Biology. PMID 30152678 DOI: 10.1021/Acschembio.8B00673 |
0.732 |
|
| 2018 |
Deng Y, Kang D, Shi J, Zhou W, Sun A, Ju J, Zhu X, Shen B, Duan Y, Huang Y. The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin. Medchemcomm. 9: 789-794. PMID 30108968 DOI: 10.1039/C8Md00081F |
0.335 |
|
| 2018 |
Kwong T, Ma M, Pan G, Hindra, Yang D, Yang C, Lohman JR, Rudolf JD, Cleveland JL, Shen B. P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities. Biochemistry. PMID 30070831 DOI: 10.1021/Acs.Biochem.8B00623 |
0.82 |
|
| 2018 |
Jiang L, Pu H, Xiang J, Su M, Yan X, Yang D, Zhu X, Shen B, Duan Y, Huang Y. Huanglongmycin A-C, Cytotoxic Polyketides Biosynthesized by a Putative Type II Polyketide Synthase From sp. CB09001. Frontiers in Chemistry. 6: 254. PMID 30013965 DOI: 10.3389/Fchem.2018.00254 |
0.399 |
|
| 2018 |
McAlpine JB, Chen SN, Kutateladze A, MacMillan JB, Appendino G, Barison A, Beniddir MA, Biavatti MW, Bluml S, Boufridi A, Butler MS, Capon RJ, Choi YH, Coppage D, Crews P, ... ... Shen B, et al. The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Natural Product Reports. PMID 30003207 DOI: 10.1039/C7Np00064B |
0.679 |
|
| 2018 |
Chang CY, Yan X, Crnovcic I, Annaval T, Chang C, Nocek B, Rudolf JD, Yang D, Hindra, Babnigg G, Joachimiak A, Phillips GN, Shen B. Resistance to Enediyne Antitumor Antibiotics by Sequestration. Cell Chemical Biology. PMID 29937405 DOI: 10.1016/J.Chembiol.2018.05.012 |
0.666 |
|
| 2018 |
Dong LB, Rudolf JD, Kang D, Wang N, He CQ, Deng Y, Huang Y, Houk KN, Duan Y, Shen B. Biosynthesis of thiocarboxylic acid-containing natural products. Nature Communications. 9: 2362. PMID 29915173 DOI: 10.1038/S41467-018-04747-Y |
0.693 |
|
| 2018 |
Wang N, Rudolf JD, Dong LB, Osipiuk J, Hatzos-Skintges C, Endres M, Chang CY, Babnigg G, Joachimiak A, Phillips GN, Shen B. Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme. Nature Chemical Biology. PMID 29867143 DOI: 10.1038/S41589-018-0061-0 |
0.694 |
|
| 2018 |
Shen B, Dong LB, Rudolf JD, Deng MR, Yan X. Discovery of the Tiancilactone Antibiotics by Genome Mining of Atypical Bacterial Type II Diterpene Synthases. Chembiochem : a European Journal of Chemical Biology. PMID 29806086 DOI: 10.1002/Cbic.201800285 |
0.713 |
|
| 2018 |
Crnovcic I, Gan F, Yang D, Dong LB, Schultz PG, Shen B. Activities of recombinant human bleomycin hydrolase on bleomycins and engineered analogues revealing new opportunities to overcome bleomycin-induced pulmonary toxicity. Bioorganic & Medicinal Chemistry Letters. PMID 29730026 DOI: 10.1016/J.Bmcl.2018.04.065 |
0.317 |
|
| 2018 |
Chang CY, Lohman JR, Huang T, Michalska K, Bigelow L, Rudolf JD, Jedrzejczak R, Yan X, Ma M, Babnigg G, Joachimiak A, Phillips GN, Shen B. Structural Insights into the Free-standing Condensation Enzyme SgcC5 Catalyzing Ester Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027. Biochemistry. PMID 29533601 DOI: 10.1021/Acs.Biochem.8B00174 |
0.814 |
|
| 2018 |
Chen JJ, Rateb ME, Love MS, Xu Z, Yang D, Zhu X, Huang Y, Zhao LX, Jiang Y, Duan Y, McNamara CW, Shen B. Herbicidins from Streptomyces sp. CB01388 Showing Anti-Cryptosporidium Activity. Journal of Natural Products. PMID 29469575 DOI: 10.1021/Acs.Jnatprod.7B00850 |
0.318 |
|
| 2018 |
Liu L, Pan J, Wang Z, Yan X, Yang D, Zhu X, Shen B, Duan Y, Huang Y. Ribosome engineering and fermentation optimization leads to overproduction of tiancimycin A, a new enediyne natural product from Streptomyces sp. CB03234. Journal of Industrial Microbiology & Biotechnology. PMID 29396746 DOI: 10.1007/S10295-018-2014-8 |
0.336 |
|
| 2018 |
Qiu L, Tian K, Wen Z, Deng Y, Kang D, Liang H, Zhu X, Shen B, Duan Y, Huang Y. Biomimetic Stereoselective Sulfa-Michael Addition Leads to Platensimycin and Platencin Sulfur Analogues against Methicillin-Resistant Staphylococcus aureus. Journal of Natural Products. PMID 29389125 DOI: 10.1021/Acs.Jnatprod.7B00745 |
0.332 |
|
| 2018 |
Yan X, Hindra, Ge H, Yang D, Huang T, Crnovcic I, Chang CY, Fang SM, Annaval T, Zhu X, Huang Y, Zhao LX, Jiang Y, Duan Y, Shen B. Discovery of Alternative Producers of the Enediyne Antitumor Antibiotic C-1027 with High Titers. Journal of Natural Products. PMID 29345939 DOI: 10.1021/Acs.Jnatprod.7B01013 |
0.368 |
|
| 2018 |
Guo X, Crnovcic I, Chang CY, Luo J, Lohman JR, Papinski M, Bechthold A, Horsman GP, Shen B. PokMT1 from the polyketomycin biosynthetic machinery of Streptomyces diastatochromogenes Tü6028 belongs to the emerging family of C-methyltransferases that act on CoA-activated aromatic substrates. Biochemistry. PMID 29341603 DOI: 10.1021/Acs.Biochem.7B01219 |
0.727 |
|
| 2017 |
Zhu X, Kong J, Yang H, Huang R, Huang Y, Yang D, Shen B, Duan Y. Strain improvement by combined UV mutagenesis and ribosome engineering and subsequent fermentation optimization for enhanced 6'-deoxy-bleomycin Z production. Applied Microbiology and Biotechnology. PMID 29279956 DOI: 10.1007/S00253-017-8705-7 |
0.339 |
|
| 2017 |
Pan G, Xu Z, Guo Z, Hindra, Ma M, Yang D, Zhou H, Gansemans Y, Zhu X, Huang Y, Zhao LX, Jiang Y, Cheng J, Van Nieuwerburgh F, Suh JW, ... Shen B, et al. Discovery of the leinamycin family of natural products by mining actinobacterial genomes. Proceedings of the National Academy of Sciences of the United States of America. PMID 29229819 DOI: 10.1073/Pnas.1716245115 |
0.699 |
|
| 2017 |
Yan X, Chen JJ, Adhikari A, Yang D, Crnovcic I, Wang N, Chang CY, Rader C, Shen B. Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne. Organic Letters. PMID 29086572 DOI: 10.1021/Acs.Orglett.7B03120 |
0.318 |
|
| 2017 |
Annaval T, Rudolf JD, Chang CY, Lohman JR, Kim Y, Bigelow L, Jedrzejczak R, Babnigg G, Joachimiak A, Phillips GN, Shen B. Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis. Acs Omega. 2: 5159-5169. PMID 28884166 DOI: 10.1021/acsomega.7b00933 |
0.8 |
|
| 2017 |
Yang D, Hindra, Dong LB, Crnovcic I, Shen B. Engineered production and evaluation of 6'-deoxy-tallysomycin H-1 revealing new insights into the structure-activity relationship of the anticancer drug bleomycin. The Journal of Antibiotics. PMID 28831149 DOI: 10.1038/Ja.2017.93 |
0.41 |
|
| 2017 |
Rudolf JD, Chang CY, Ma M, Shen B. Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function. Natural Product Reports. PMID 28758170 DOI: 10.1039/C7Np00034K |
0.684 |
|
| 2017 |
Qiu L, Tian K, Pan J, Jiang L, Yang H, Zhu X, Shen B, Duan Y, Huang Y. A Facile Semi-Synthetic Approach towards Halogen-Substituted Aminobenzoic Acid Analogues of Platensimycin. Tetrahedron. 73: 771-775. PMID 28626267 DOI: 10.1016/J.Tet.2016.12.059 |
0.369 |
|
| 2017 |
Falzone M, Crespo E, Jones K, Khan G, Korn VL, Patel A, Patel M, Patel K, Perkins C, Siddiqui S, Stenger D, Yu E, Gelber M, Scheffler R, Nayda V, ... ... Shen B, et al. Nutritional control of antibiotic production by Streptomyces platensis MA7327: importance of l-aspartic acid. The Journal of Antibiotics. PMID 28465627 DOI: 10.1038/Ja.2017.49 |
0.682 |
|
| 2017 |
Shen B, Zhang B, Xu Z, Teng Q, Pan G, Ma M. A long-range acting dehydratase domain as the missing link for C17-dehydration in iso-migrastatin biosynthesis. Angewandte Chemie (International Ed. in English). PMID 28464455 DOI: 10.1002/Anie.201703588 |
0.676 |
|
| 2017 |
Hindra, Yang D, Teng Q, Dong LB, Crnovčić I, Huang T, Ge H, Shen B. Genome Mining of Streptomyces mobaraensis DSM40847 as a Bleomycin Producer Providing a Biotechnology Platform To Engineer Designer Bleomycin Analogues. Organic Letters. PMID 28256838 DOI: 10.1021/Acs.Orglett.7B00283 |
0.317 |
|
| 2017 |
Dong LB, Rudolf JD, Lin L, Ruiz C, Cameron MD, Shen B. In vivo instability of platensimycin and platencin: Synthesis and biological evaluation of urea- and carbamate-platensimycin. Bioorganic & Medicinal Chemistry. PMID 28237556 DOI: 10.1016/J.Bmc.2017.02.028 |
0.684 |
|
| 2017 |
Yang D, Rateb ME, Wang N, Shen B. Competition and co-regulation of spirotoamide and tautomycetin biosynthesis in Streptomyces griseochromogenes, and isolation and structural elucidation of spirotoamide C and D. The Journal of Antibiotics. PMID 28196980 DOI: 10.1038/Ja.2017.13 |
0.32 |
|
| 2016 |
Yan X, Ge H, Huang T, Hindra, Yang D, Teng Q, Crnovčić I, Li X, Rudolf JD, Lohman JR, Gansemans Y, Zhu X, Huang Y, Zhao LX, Jiang Y, ... Shen B, et al. Strain Prioritization and Genome Mining for Enediyne Natural Products. Mbio. 7. PMID 27999165 DOI: 10.1128/Mbio.02104-16 |
0.81 |
|
| 2016 |
Rudolf JD, Dong LB, Manoogian K, Shen B. Biosynthetic Origin of the Ether Ring in Platensimycin. Journal of the American Chemical Society. PMID 27966343 DOI: 10.1021/Jacs.6B09818 |
0.733 |
|
| 2016 |
Rudolf JD, Dong LB, Shen B. Platensimycin and Platencin: Inspirations for Chemistry, Biology, Enzymology, and Medicine. Biochemical Pharmacology. PMID 27865713 DOI: 10.1016/J.Bcp.2016.11.013 |
0.701 |
|
| 2016 |
Guo Z, Pan G, Xu Z, Yang D, Hindra, Zhu X, Huang Y, Zhao LX, Jiang Y, Duan Y, Shen B. New isofuranonaphthoquinones and isoindolequinones from Streptomyces sp. CB01883. The Journal of Antibiotics. PMID 27731333 DOI: 10.1038/Ja.2016.122 |
0.694 |
|
| 2016 |
Huang Y, Yang D, Pan G, Tang GL, Shen B. Characterization of LnmO as a pathway-specific Crp/Fnr-type positive regulator for leinamycin biosynthesis in Streptomyces atroolivaceus and its application for titer improvement. Applied Microbiology and Biotechnology. PMID 27704182 DOI: 10.1007/S00253-016-7864-2 |
0.679 |
|
| 2016 |
Dong LB, Rudolf JD, Shen B. A Mutasynthetic Library of Platensimycin and Platencin Analogues. Organic Letters. PMID 27599271 DOI: 10.1021/Acs.Orglett.6B02248 |
0.666 |
|
| 2016 |
Chang CY, Lohman JR, Cao H, Tan K, Rudolf JD, Ma M, Xu W, Bingman CA, Yennamalli RM, Bigelow L, Babnigg G, Yan X, Joachimiak A, Phillips GN, Shen B. Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase that Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate in Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus. Biochemistry. PMID 27560143 DOI: 10.1021/Acs.Biochem.6B00713 |
0.805 |
|
| 2016 |
Huang Y, Tang GL, Pan G, Chang CY, Shen B. Characterization of the Ketosynthase and Acyl Carrier Protein Domains at the LnmI Nonribosomal Peptide Synthetase-Polyketide Synthase Interface for Leinamycin Biosynthesis. Organic Letters. PMID 27541042 DOI: 10.1021/Acs.Orglett.6B02033 |
0.647 |
|
| 2016 |
Ma M, Rateb ME, Yang D, Rudolf JD, Zhu X, Huang Y, Zhao LX, Jiang Y, Duan Y, Shen B. Germicidins H-J from Streptomyces sp. CB00361. The Journal of Antibiotics. PMID 27507632 DOI: 10.1038/Ja.2016.100 |
0.622 |
|
| 2016 |
Rudolf JD, Dong LB, Cao H, Hatzos-Skintges C, Osipiuk J, Endres M, Chang CY, Ma M, Babnigg G, Joachimiak A, Phillips GN, Shen B. Structure of the ent-Copalyl Diphosphate Synthase PtmT2 from Streptomyces platensis CB00739, a Bacterial Type II Diterpene Synthase. Journal of the American Chemical Society. PMID 27490479 DOI: 10.1021/Jacs.6B04317 |
0.687 |
|
| 2016 |
Huang T, Chang CY, Lohman JR, Rudolf JD, Kim Y, Chang C, Yang D, Ma M, Yan X, Crnovcic I, Bigelow L, Clancy S, Bingman CA, Yennamalli RM, Babnigg G, ... ... Shen B, et al. Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027. The Journal of Antibiotics. PMID 27406907 DOI: 10.1038/Ja.2016.88 |
0.82 |
|
| 2016 |
Dong LB, Rudolf JD, Shen B. Antibacterial sulfur-containing platensimycin and platencin congeners from Streptomyces platensis SB12029. Bioorganic & Medicinal Chemistry. PMID 27134119 DOI: 10.1016/J.Bmc.2016.04.026 |
0.708 |
|
| 2016 |
Shi J, Pan J, Liu L, Yang D, Lu S, Zhu X, Shen B, Duan Y, Huang Y. Titer improvement and pilot-scale production of platensimycin from Streptomyces platensis SB12026. Journal of Industrial Microbiology & Biotechnology. PMID 27126098 DOI: 10.1007/S10295-016-1769-Z |
0.354 |
|
| 2016 |
Li W, Li X, Huang T, Teng Q, Crnovcic I, Rader C, Shen B. Engineered production of cancer targeting peptide (CTP)-containing C-1027 in Streptomyces globisporus and biological evaluation. Bioorganic & Medicinal Chemistry. PMID 27094150 DOI: 10.1016/J.Bmc.2016.04.017 |
0.35 |
|
| 2016 |
Smanski MJ, Zhou H, Claesen J, Shen B, Fischbach MA, Voigt CA. Synthetic biology to access and expand nature's chemical diversity. Nature Reviews. Microbiology. 14: 135-49. PMID 26876034 DOI: 10.1038/Nrmicro.2015.24 |
0.716 |
|
| 2015 |
Zhang B, Yang D, Yan Y, Pan G, Xiang W, Shen B. Overproduction of lactimidomycin by cross-overexpression of genes encoding Streptomyces antibiotic regulatory proteins. Applied Microbiology and Biotechnology. PMID 26552797 DOI: 10.1007/S00253-015-7119-7 |
0.696 |
|
| 2015 |
Rudolf JD, Bigelow L, Chang C, Cuff ME, Lohman JR, Chang CY, Ma M, Yang D, Clancy S, Babnigg G, Joachimiak A, Phillips GN, Shen B. Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892. Biochemistry. PMID 26512730 DOI: 10.1021/Acs.Biochem.5B01008 |
0.784 |
|
| 2015 |
Lohman JR, Ma M, Osipiuk J, Nocek B, Kim Y, Chang C, Cuff M, Mack J, Bigelow L, Li H, Endres M, Babnigg G, Joachimiak A, Phillips GN, Shen B. Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases. Proceedings of the National Academy of Sciences of the United States of America. PMID 26420866 DOI: 10.1073/Pnas.1515460112 |
0.705 |
|
| 2015 |
Ma M, Rateb ME, Teng Q, Yang D, Rudolf JD, Zhu X, Huang Y, Zhao LX, Jiang Y, Li X, Rader C, Duan Y, Shen B. Angucyclines and Angucyclinones from Streptomyces sp. CB01913 Featuring C-Ring Cleavage and Expansion. Journal of Natural Products. PMID 26335269 DOI: 10.1021/Acs.Jnatprod.5B00601 |
0.693 |
|
| 2015 |
Rudolf JD, Yan X, Shen B. Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery. Journal of Industrial Microbiology & Biotechnology. PMID 26318027 DOI: 10.1007/S10295-015-1671-0 |
0.703 |
|
| 2015 |
Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, ... ... Shen B, et al. Minimum Information about a Biosynthetic Gene cluster. Nature Chemical Biology. 11: 625-31. PMID 26284661 DOI: 10.1038/Nchembio.1890 |
0.789 |
|
| 2015 |
Ma M, Lohman JR, Liu T, Shen B. C-S bond cleavage by a polyketide synthase domain. Proceedings of the National Academy of Sciences of the United States of America. 112: 10359-64. PMID 26240335 DOI: 10.1073/Pnas.1508437112 |
0.73 |
|
| 2015 |
Liu T, Ma M, Ge HM, Yang C, Cleveland J, Shen B. Synthesis and evaluation of 8,4'-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin. Bioorganic & Medicinal Chemistry Letters. PMID 26071634 DOI: 10.1016/J.Bmcl.2015.05.078 |
0.398 |
|
| 2015 |
Huang SX, Yun BS, Ma M, Basu HS, Church DR, Ingenhorst G, Huang Y, Yang D, Lohman JR, Tang GL, Ju J, Liu T, Wilding G, Shen B. Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species. Proceedings of the National Academy of Sciences of the United States of America. 112: 8278-83. PMID 26056295 DOI: 10.1073/Pnas.1506761112 |
0.699 |
|
| 2015 |
Rudolf JD, Dong LB, Huang T, Shen B. A genetically amenable platensimycin- and platencin-overproducer as a platform for biosynthetic explorations: a showcase of PtmO4, a long-chain acyl-CoA dehydrogenase. Molecular Biosystems. PMID 26055255 DOI: 10.1039/C5Mb00303B |
0.704 |
|
| 2015 |
Shen B, Hindra, Yan X, Huang T, Ge H, Yang D, Teng Q, Rudolf JD, Lohman JR. Enediynes: Exploration of microbial genomics to discover new anticancer drug leads. Bioorganic & Medicinal Chemistry Letters. 25: 9-15. PMID 25434000 DOI: 10.1016/J.Bmcl.2014.11.019 |
0.777 |
|
| 2015 |
Lohman J, Joachimiak A, Phillips Jr G, Shen B. Structural and evolutionary relationships of ketosynthase domains from modular polyketide synthases Planta Medica. 81. DOI: 10.1055/s-0035-1556231 |
0.643 |
|
| 2014 |
Seo JW, Ma M, Kwong T, Ju J, Lim SK, Jiang H, Lohman JR, Yang C, Cleveland J, Zazopoulos E, Farnet CM, Shen B. Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues. Biochemistry. 53: 7854-65. PMID 25405956 DOI: 10.1021/Bi501396V |
0.752 |
|
| 2014 |
Coughlin JM, Rudolf JD, Wendt-Pienkowski E, Wang L, Unsin C, Galm U, Yang D, Tao M, Shen B. BlmB and TlmB provide resistance to the bleomycin family of antitumor antibiotics by N-acetylating metal-free bleomycin, tallysomycin, phleomycin, and zorbamycin. Biochemistry. 53: 6901-9. PMID 25299801 DOI: 10.1021/Bi501121E |
0.794 |
|
| 2014 |
Hindra, Huang T, Yang D, Rudolf JD, Xie P, Xie G, Teng Q, Lohman JR, Zhu X, Huang Y, Zhao LX, Jiang Y, Duan Y, Shen B. Strain prioritization for natural product discovery by a high-throughput real-time PCR method. Journal of Natural Products. 77: 2296-303. PMID 25238028 DOI: 10.1021/Np5006168 |
0.783 |
|
| 2014 |
Lohman JR, Ma M, Cuff ME, Bigelow L, Bearden J, Babnigg G, Joachimiak A, Phillips GN, Shen B. The crystal structure of BlmI as a model for nonribosomal peptide synthetase peptidyl carrier proteins. Proteins. 82: 1210-8. PMID 25050442 DOI: 10.1002/Prot.24485 |
0.693 |
|
| 2014 |
Ge HM, Huang T, Rudolf JD, Lohman JR, Huang SX, Guo X, Shen B. Enediyne polyketide synthases stereoselectively reduce the β-ketoacyl intermediates to β-D-hydroxyacyl intermediates in enediyne core biosynthesis. Organic Letters. 16: 3958-61. PMID 25019332 DOI: 10.1021/Ol501767V |
0.763 |
|
| 2014 |
Yin M, Yan Y, Lohman JR, Huang SX, Ma M, Zhao GR, Xu LH, Xiang W, Shen B. Cycloheximide and actiphenol production in Streptomyces sp. YIM56141 governed by single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase. Organic Letters. 16: 3072-5. PMID 24815182 DOI: 10.1021/Ol501179W |
0.728 |
|
| 2014 |
Peterson RM, Huang T, Rudolf JD, Smanski MJ, Shen B. Mechanisms of self-resistance in the platensimycin- and platencin-producing Streptomyces platensis MA7327 and MA7339 strains. Chemistry & Biology. 21: 389-97. PMID 24560608 DOI: 10.1016/J.Chembiol.2014.01.005 |
0.796 |
|
| 2014 |
Xie P, Ma M, Rateb ME, Shaaban KA, Yu Z, Huang SX, Zhao LX, Zhu X, Yan Y, Peterson RM, Lohman JR, Yang D, Yin M, Rudolf JD, Jiang Y, ... ... Shen B, et al. Biosynthetic potential-based strain prioritization for natural product discovery: a showcase for diterpenoid-producing actinomycetes. Journal of Natural Products. 77: 377-87. PMID 24484381 DOI: 10.1021/Np401063S |
0.799 |
|
| 2014 |
Rateb ME, Yu Z, Yan Y, Yang D, Huang T, Vodanovic-Jankovic S, Kron MA, Shen B. Medium optimization of Streptomyces sp. 17944 for tirandamycin B production and isolation and structural elucidation of tirandamycins H, I and J. The Journal of Antibiotics. 67: 127-32. PMID 23715040 DOI: 10.1038/Ja.2013.50 |
0.324 |
|
| 2013 |
Falzone M, Martens E, Tynan H, Maggio C, Golden S, Nayda V, Crespo E, Inamine G, Gelber M, Lemence R, Chiappini N, Friedman E, Shen B, Gullo V, Demain AL. Development of a chemically defined medium for the production of the antibiotic platensimycin by Streptomyces platensis. Applied Microbiology and Biotechnology. 97: 9535-9. PMID 24022611 DOI: 10.1007/S00253-013-5201-6 |
0.315 |
|
| 2013 |
Horsman GP, Lechner A, Ohnishi Y, Moore BS, Shen B. Predictive model for epoxide hydrolase-generated stereochemistry in the biosynthesis of nine-membered enediyne antitumor antibiotics. Biochemistry. 52: 5217-24. PMID 23844627 DOI: 10.1021/Bi400572A |
0.724 |
|
| 2013 |
Huang SX, Lohman JR, Huang T, Shen B. A new member of the 4-methylideneimidazole-5-one-containing aminomutase family from the enediyne kedarcidin biosynthetic pathway. Proceedings of the National Academy of Sciences of the United States of America. 110: 8069-74. PMID 23633564 DOI: 10.1073/Pnas.1304733110 |
0.709 |
|
| 2013 |
Ma M, Kwong T, Lim SK, Ju J, Lohman JR, Shen B. Post-polyketide synthase steps in iso-migrastatin biosynthesis, featuring tailoring enzymes with broad substrate specificity. Journal of the American Chemical Society. 135: 2489-92. PMID 23394593 DOI: 10.1021/Ja4002635 |
0.726 |
|
| 2013 |
Yu Z, Rateb ME, Smanski MJ, Peterson RM, Shen B. Isolation and structural elucidation of glucoside congeners of platencin from Streptomyces platensis SB12600. The Journal of Antibiotics. 66: 291-4. PMID 23361357 DOI: 10.1038/Ja.2013.1 |
0.687 |
|
| 2013 |
Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B. Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics. Molecular Biosystems. 9: 478-91. PMID 23360970 DOI: 10.1039/C3Mb25523A |
0.821 |
|
| 2013 |
Lohman JR, Bingman CA, Phillips GN, Shen B. Structure of the bifunctional acyltransferase/decarboxylase LnmK from the leinamycin biosynthetic pathway revealing novel activity for a double-hot-dog fold. Biochemistry. 52: 902-11. PMID 23320975 DOI: 10.1021/Bi301652Y |
0.711 |
|
| 2013 |
Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, ... ... Shen B, et al. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Natural Product Reports. 30: 108-60. PMID 23165928 DOI: 10.1039/C2Np20085F |
0.403 |
|
| 2013 |
Tebbets B, Yu Z, Stewart D, Zhao LX, Jiang Y, Xu LH, Andes D, Shen B, Klein B. Identification of antifungal natural products via Saccharomyces cerevisiae bioassay: insights into macrotetrolide drug spectrum, potency and mode of action. Medical Mycology. 51: 280-9. PMID 22928922 DOI: 10.3109/13693786.2012.710917 |
0.36 |
|
| 2013 |
Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, ... ... Shen B, et al. Erratum: Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature (Natural Product Reports (2013) 30 (108-160) DOI:10.1039/C2NP20085F) Natural Product Reports. 30: 1568-1568. DOI: 10.1039/C3Np90040A |
0.416 |
|
| 2012 |
Smanski MJ, Casper J, Peterson RM, Yu Z, Rajski SR, Shen B. Expression of the platencin biosynthetic gene cluster in heterologous hosts yielding new platencin congeners. Journal of Natural Products. 75: 2158-67. PMID 23157615 DOI: 10.1021/Np3005985 |
0.753 |
|
| 2012 |
Lin S, Huang T, Shen B. Tailoring enzymes acting on carrier protein-tethered substrates in natural product biosynthesis. Methods in Enzymology. 516: 321-43. PMID 23034236 DOI: 10.1016/B978-0-12-394291-3.00008-3 |
0.407 |
|
| 2012 |
Lohman JR, Shen B. 4-methylideneimidazole-5-one-containing aminomutases in enediyne biosynthesis. Methods in Enzymology. 516: 299-319. PMID 23034235 DOI: 10.1016/B978-0-12-394291-3.00007-1 |
0.717 |
|
| 2012 |
Smanski MJ, Peterson RM, Shen B. Platensimycin and platencin biosynthesis in Streptomyces platensis, showcasing discovery and characterization of novel bacterial diterpene synthases. Methods in Enzymology. 515: 163-86. PMID 22999174 DOI: 10.1016/B978-0-12-394290-6.00008-2 |
0.73 |
|
| 2012 |
Huang SX, Feng Z, Wang L, Galm U, Wendt-Pienkowski E, Yang D, Tao M, Coughlin JM, Duan Y, Shen B. A designer bleomycin with significantly improved DNA cleavage activity. Journal of the American Chemical Society. 134: 13501-9. PMID 22831455 DOI: 10.1021/Ja3056535 |
0.73 |
|
| 2012 |
Lin S, Huang T, Horsman GP, Huang SX, Guo X, Shen B. Specificity of the ester bond forming condensation enzyme SgcC5 in C-1027 biosynthesis. Organic Letters. 14: 2300-3. PMID 22519717 DOI: 10.1021/Ol300720S |
0.716 |
|
| 2012 |
Shen B, Thorson JS. Expanding nature's chemical repertoire through metabolic engineering and biocatalysis. Current Opinion in Chemical Biology. 16: 99-100. PMID 22464247 DOI: 10.1016/J.Cbpa.2012.03.006 |
0.525 |
|
| 2012 |
Smanski MJ, Peterson RM, Huang SX, Shen B. Bacterial diterpene synthases: new opportunities for mechanistic enzymology and engineered biosynthesis. Current Opinion in Chemical Biology. 16: 132-41. PMID 22445175 DOI: 10.1016/J.Cbpa.2012.03.002 |
0.716 |
|
| 2012 |
Yang D, Li W, Huang SX, Shen B. Functional characterization of ttnI completing the tailoring steps for tautomycetin biosynthesis in Streptomyces griseochromogenes. Organic Letters. 14: 1302-5. PMID 22339318 DOI: 10.1021/Ol300187P |
0.384 |
|
| 2012 |
Huang SX, Wang XJ, Yan Y, Wang JD, Zhang J, Liu CX, Xiang WS, Shen B. Neaumycin: a new macrolide from Streptomyces sp. NEAU-x211. Organic Letters. 14: 1254-7. PMID 22332843 DOI: 10.1021/Ol300074D |
0.312 |
|
| 2011 |
Zhao LX, Huang SX, Tang SK, Jiang CL, Duan Y, Beutler JA, Henrich CJ, McMahon JB, Schmid T, Blees JS, Colburn NH, Rajski SR, Shen B. Actinopolysporins A-C and tubercidin as a Pdcd4 stabilizer from the halophilic actinomycete Actinopolyspora erythraea YIM 90600. Journal of Natural Products. 74: 1990-5. PMID 21870828 DOI: 10.1021/Np200603G |
0.37 |
|
| 2011 |
Smanski MJ, Yu Z, Casper J, Lin S, Peterson RM, Chen Y, Wendt-Pienkowski E, Rajski SR, Shen B. Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 108: 13498-503. PMID 21825154 DOI: 10.1073/Pnas.1106919108 |
0.733 |
|
| 2011 |
Yin M, Lu T, Zhao LX, Chen Y, Huang SX, Lohman JR, Xu LH, Jiang CL, Shen B. The missing C-17 O-methyltransferase in geldanamycin biosynthesis. Organic Letters. 13: 3726-9. PMID 21682254 DOI: 10.1021/Ol201383W |
0.715 |
|
| 2011 |
Chen Y, Yin M, Horsman GP, Shen B. Improvement of the enediyne antitumor antibiotic C-1027 production by manipulating its biosynthetic pathway regulation in Streptomyces globisporus. Journal of Natural Products. 74: 420-4. PMID 21250756 DOI: 10.1021/Np100825Y |
0.746 |
|
| 2011 |
Zhang Q, Li Y, Chen D, Yu Y, Duan L, Shen B, Liu W. Radical-mediated enzymatic carbon chain fragmentation-recombination. Nature Chemical Biology. 7: 154-60. PMID 21240261 DOI: 10.1038/Nchembio.512 |
0.456 |
|
| 2011 |
Galm U, Wendt-Pienkowski E, Wang L, Huang SX, Unsin C, Tao M, Coughlin JM, Shen B. Comparative analysis of the biosynthetic gene clusters and pathways for three structurally related antitumor antibiotics: bleomycin, tallysomycin, and zorbamycin. Journal of Natural Products. 74: 526-36. PMID 21210656 DOI: 10.1021/Np1008152 |
0.761 |
|
| 2011 |
Yang D, Zhu X, Wu X, Feng Z, Huang L, Shen B, Xu Z. Titer improvement of iso-migrastatin in selected heterologous Streptomyces hosts and related analysis of mRNA expression by quantitative RT-PCR. Applied Microbiology and Biotechnology. 89: 1709-19. PMID 21132287 DOI: 10.1007/S00253-010-3025-1 |
0.339 |
|
| 2010 |
Wu X, Yang D, Zhu X, Feng Z, Lv Z, Zhang Y, Shen B, Xu Z. Iso-migrastatin Titer Improvement in the Engineered Streptomyces lividans SB11002 Strain by Optimization of Fermentation Conditions. Biotechnology and Bioprocess Engineering : Bbe. 15: 664-669. PMID 21625393 DOI: 10.1007/S12257-009-3129-6 |
0.319 |
|
| 2010 |
Yu Y, Guo H, Zhang Q, Duan L, Ding Y, Liao R, Lei C, Shen B, Liu W. NosA catalyzing carboxyl-terminal amide formation in nosiheptide maturation via an enamine dealkylation on the serine-extended precursor peptide. Journal of the American Chemical Society. 132: 16324-6. PMID 21047073 DOI: 10.1021/Ja106571G |
0.436 |
|
| 2010 |
Chen Y, Wendt-Pienkowski E, Ju J, Lin S, Rajski SR, Shen B. Characterization of FdmV as an amide synthetase for fredericamycin A biosynthesis in Streptomyces griseus ATCC 43944. The Journal of Biological Chemistry. 285: 38853-60. PMID 20926388 DOI: 10.1074/Jbc.M110.147744 |
0.408 |
|
| 2010 |
Rajski SR, Shen B. Multifaceted modes of action for the glutarimide-containing polyketides revealed. Chembiochem : a European Journal of Chemical Biology. 11: 1951-4. PMID 20806307 DOI: 10.1002/Cbic.201000370 |
0.338 |
|
| 2010 |
Ling J, Horsman GP, Huang SX, Luo Y, Lin S, Shen B. Enediyne antitumor antibiotic maduropeptin biosynthesis featuring a C-methyltransferase that acts on a CoA-tethered aromatic substrate. Journal of the American Chemical Society. 132: 12534-6. PMID 20718468 DOI: 10.1021/Ja1050814 |
0.726 |
|
| 2010 |
Lin S, Horsman GP, Shen B. Characterization of the epoxide hydrolase NcsF2 from the neocarzinostatin biosynthetic gene cluster. Organic Letters. 12: 3816-9. PMID 20704329 DOI: 10.1021/Ol101473T |
0.721 |
|
| 2010 |
Huang SX, Powell E, Rajski SR, Zhao LX, Jiang CL, Duan Y, Xu W, Shen B. Discovery and total synthesis of a new estrogen receptor heterodimerizing actinopolymorphol A from Actinopolymorpha rutilus. Organic Letters. 12: 3525-7. PMID 20593804 DOI: 10.1021/Ol1013526 |
0.318 |
|
| 2010 |
Chen Y, Yin M, Horsman GP, Huang S, Shen B. Manipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027. The Journal of Antibiotics. 63: 482-5. PMID 20551990 DOI: 10.1038/Ja.2010.55 |
0.741 |
|
| 2010 |
Horsman GP, Chen Y, Thorson JS, Shen B. Polyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynes. Proceedings of the National Academy of Sciences of the United States of America. 107: 11331-5. PMID 20534556 DOI: 10.1073/Pnas.1003442107 |
0.789 |
|
| 2010 |
Luo Y, Li W, Ju J, Yuan Q, Peters NR, Hoffmann FM, Huang SX, Bugni TS, Rajski S, Osada H, Shen B. Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis. Journal of the American Chemical Society. 132: 6663-71. PMID 20426415 DOI: 10.1021/Ja9082446 |
0.432 |
|
| 2010 |
Zhao C, Coughlin JM, Ju J, Zhu D, Wendt-Pienkowski E, Zhou X, Wang Z, Shen B, Deng Z. Oxazolomycin biosynthesis in Streptomyces albus JA3453 featuring an "acyltransferase-less" type I polyketide synthase that incorporates two distinct extender units. The Journal of Biological Chemistry. 285: 20097-108. PMID 20406823 DOI: 10.1074/Jbc.M109.090092 |
0.768 |
|
| 2010 |
Yu Z, Smanski MJ, Peterson RM, Marchillo K, Andes D, Rajski SR, Shen B. Engineering of Streptomyces platensis MA7339 for overproduction of platencin and congeners. Organic Letters. 12: 1744-7. PMID 20232845 DOI: 10.1021/Ol100342M |
0.722 |
|
| 2010 |
Schneider-Poetsch T, Ju J, Eyler DE, Dang Y, Bhat S, Merrick WC, Green R, Shen B, Liu JO. Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin. Nature Chemical Biology. 6: 209-217. PMID 20118940 DOI: 10.1038/Nchembio.304 |
0.327 |
|
| 2010 |
Tao M, Wang L, Wendt-Pienkowski E, Zhang N, Yang D, Galm U, Coughlin JM, Xu Z, Shen B. Functional characterization of tlmH in Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insight into tallysomycin biosynthesis and affording a novel bleomycin analog. Molecular Biosystems. 6: 349-56. PMID 20094654 DOI: 10.1039/B918106G |
0.744 |
|
| 2010 |
Chen Y, Smanski MJ, Shen B. Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation. Applied Microbiology and Biotechnology. 86: 19-25. PMID 20091304 DOI: 10.1007/S00253-009-2428-3 |
0.705 |
|
| 2010 |
Zhang N, Zhu X, Yang D, Cai J, Tao M, Wang L, Duan Y, Shen B, Xu Z. Improved production of the tallysomycin H-1 in Streptoalloteichus hindustanus SB8005 strain by fermentation optimization. Applied Microbiology and Biotechnology. 86: 1345-53. PMID 20049429 DOI: 10.1007/S00253-009-2406-9 |
0.311 |
|
| 2009 |
Lin S, Horsman GP, Chen Y, Li W, Shen B. Characterization of the SgcF epoxide hydrolase supporting an (R)-vicinal diol intermediate for enediyne antitumor antibiotic C-1027 biosynthesis. Journal of the American Chemical Society. 131: 16410-7. PMID 19856960 DOI: 10.1021/Ja901242S |
0.726 |
|
| 2009 |
Van Lanen SG, Lin S, Horsman GP, Shen B. Characterization of SgcE6, the flavin reductase component supporting FAD-dependent halogenation and hydroxylation in the biosynthesis of the enediyne antitumor antibiotic C-1027. Fems Microbiology Letters. 300: 237-41. PMID 19817865 DOI: 10.1111/J.1574-6968.2009.01802.X |
0.74 |
|
| 2009 |
Lim SK, Ju J, Zazopoulos E, Jiang H, Seo JW, Chen Y, Feng Z, Rajski SR, Farnet CM, Shen B. iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase. The Journal of Biological Chemistry. 284: 29746-56. PMID 19726666 DOI: 10.1074/Jbc.M109.046805 |
0.416 |
|
| 2009 |
Cooke HA, Guenther EL, Luo Y, Shen B, Bruner SD. Molecular basis of substrate promiscuity for the SAM-dependent O-methyltransferase NcsB1, involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. Biochemistry. 48: 9590-8. PMID 19702337 DOI: 10.1021/Bi901257Q |
0.395 |
|
| 2009 |
Yu Y, Duan L, Zhang Q, Liao R, Ding Y, Pan H, Wendt-Pienkowski E, Tang G, Shen B, Liu W. Nosiheptide biosynthesis featuring a unique indole side ring formation on the characteristic thiopeptide framework. Acs Chemical Biology. 4: 855-64. PMID 19678698 DOI: 10.1021/Cb900133X |
0.519 |
|
| 2009 |
Chen Y, Wendt-Pienkoski E, Rajski SR, Shen B. In vivo investigation of the roles of FdmM and FdmM1 in fredericamycin biosynthesis unveiling a new family of oxygenases. The Journal of Biological Chemistry. 284: 24735-43. PMID 19620242 DOI: 10.1074/Jbc.M109.014191 |
0.438 |
|
| 2009 |
Liu T, Huang Y, Shen B. Bifunctional acyltransferase/decarboxylase LnmK as the missing link for beta-alkylation in polyketide biosynthesis. Journal of the American Chemical Society. 131: 6900-1. PMID 19405532 DOI: 10.1021/Ja9012134 |
0.301 |
|
| 2009 |
Cheng YQ, Coughlin JM, Lim SK, Shen B. Type I polyketide synthases that require discrete acyltransferases. Methods in Enzymology. 459: 165-86. PMID 19362640 DOI: 10.1016/S0076-6879(09)04608-4 |
0.738 |
|
| 2009 |
Horsman GP, Van Lanen SG, Shen B. Iterative type I polyketide synthases for enediyne core biosynthesis. Methods in Enzymology. 459: 97-112. PMID 19362637 DOI: 10.1016/S0076-6879(09)04605-9 |
0.753 |
|
| 2009 |
Jiang H, Rajski SR, Shen B. Tandem acyl carrier protein domains in polyunsaturated fatty acid synthases. Methods in Enzymology. 459: 79-96. PMID 19362636 DOI: 10.1016/S0076-6879(09)04604-7 |
0.317 |
|
| 2009 |
Ju J, Li W, Yuan Q, Peters NR, Hoffmann FM, Rajski SR, Osada H, Shen B. Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity. Organic Letters. 11: 1639-42. PMID 19281218 DOI: 10.1021/Ol900293J |
0.396 |
|
| 2009 |
Lin S, Van Lanen SG, Shen B. A free-standing condensation enzyme catalyzing ester bond formation in C-1027 biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 106: 4183-8. PMID 19246381 DOI: 10.1073/Pnas.0808880106 |
0.366 |
|
| 2009 |
Liao R, Duan L, Lei C, Pan H, Ding Y, Zhang Q, Chen D, Shen B, Yu Y, Liu W. Thiopeptide biosynthesis featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications. Chemistry & Biology. 16: 141-7. PMID 19246004 DOI: 10.1016/J.Chembiol.2009.01.007 |
0.515 |
|
| 2009 |
Huang SX, Zhao LX, Tang SK, Jiang CL, Duan Y, Shen B. Erythronolides H and I, new erythromycin congeners from a new halophilic actinomycete Actinopolyspora sp. YIM90600. Organic Letters. 11: 1353-6. PMID 19228040 DOI: 10.1021/Ol900143J |
0.323 |
|
| 2009 |
Li W, Luo Y, Ju J, Rajski SR, Osada H, Shen B. Characterization of the tautomycetin biosynthetic gene cluster from Streptomyces griseochromogenes provides new insight into dialkylmaleic anhydride biosynthesis. Journal of Natural Products. 72: 450-9. PMID 19191560 DOI: 10.1021/Np8007478 |
0.449 |
|
| 2009 |
Wang L, Tao M, Wendt-Pienkoski E, Galm U, Coughlin JM, Shen B. Functional characterization of tlmK unveiling unstable carbinolamide intermediates in the tallysomycin biosynthetic pathway. The Journal of Biological Chemistry. 284: 8256-64. PMID 19189972 DOI: 10.1074/Jbc.M900640200 |
0.724 |
|
| 2009 |
Smanski MJ, Peterson RM, Rajski SR, Shen B. Engineered Streptomyces platensis strains that overproduce antibiotics platensimycin and platencin. Antimicrobial Agents and Chemotherapy. 53: 1299-304. PMID 19164156 DOI: 10.1128/Aac.01358-08 |
0.728 |
|
| 2009 |
Ju J, Rajski SR, Lim SK, Seo JW, Peters NR, Hoffmann FM, Shen B. Lactimidomycin, iso-migrastatin and related glutarimide-containing 12-membered macrolides are extremely potent inhibitors of cell migration. Journal of the American Chemical Society. 131: 1370-1. PMID 19132897 DOI: 10.1021/Ja808462P |
0.311 |
|
| 2009 |
Galm U, Wendt-Pienkowski E, Wang L, George NP, Oh TJ, Yi F, Tao M, Coughlin JM, Shen B. The biosynthetic gene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridis ATCC 21892. Molecular Biosystems. 5: 77-90. PMID 19081934 DOI: 10.1039/B814075H |
0.749 |
|
| 2009 |
Feng Z, Wang L, Rajski SR, Xu Z, Coeffet-LeGal MF, Shen B. Engineered production of iso-migrastatin in heterologous Streptomyces hosts. Bioorganic & Medicinal Chemistry. 17: 2147-53. PMID 19010685 DOI: 10.1016/J.Bmc.2008.10.074 |
0.35 |
|
| 2008 |
Li W, Ju J, Rajski SR, Osada H, Shen B. Characterization of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus unveiling new insights into dialkylmaleic anhydride and polyketide biosynthesis. The Journal of Biological Chemistry. 283: 28607-17. PMID 18708355 DOI: 10.1074/Jbc.M804279200 |
0.442 |
|
| 2008 |
Galm U, Wang L, Wendt-Pienkowski E, Yang R, Liu W, Tao M, Coughlin JM, Shen B. In vivo manipulation of the bleomycin biosynthetic gene cluster in Streptomyces verticillus ATCC15003 revealing new insights into its biosynthetic pathway. The Journal of Biological Chemistry. 283: 28236-45. PMID 18697737 DOI: 10.1074/Jbc.M804971200 |
0.776 |
|
| 2008 |
Chen Y, Wendt-Pienkowski E, Shen B. Identification and utility of FdmR1 as a Streptomyces antibiotic regulatory protein activator for fredericamycin production in Streptomyces griseus ATCC 49344 and heterologous hosts. Journal of Bacteriology. 190: 5587-96. PMID 18556785 DOI: 10.1128/Jb.00592-08 |
0.418 |
|
| 2008 |
Jiang H, Zirkle R, Metz JG, Braun L, Richter L, Van Lanen SG, Shen B. The role of tandem acyl carrier protein domains in polyunsaturated fatty acid biosynthesis. Journal of the American Chemical Society. 130: 6336-7. PMID 18444614 DOI: 10.1021/Ja801911T |
0.314 |
|
| 2008 |
Lin S, Van Lanen SG, Shen B. Characterization of the two-component, FAD-dependent monooxygenase SgcC that requires carrier protein-tethered substrates for the biosynthesis of the enediyne antitumor antibiotic C-1027. Journal of the American Chemical Society. 130: 6616-23. PMID 18426211 DOI: 10.1021/Ja710601D |
0.354 |
|
| 2008 |
Song D, Coughlin J, Ju J, Zhou X, Shen B, Zhao C, Deng Z. Alternative method for site-directed mutagenesis of complex polyketide synthase in Streptomyces albus JA3453. Acta Biochimica Et Biophysica Sinica. 40: 319-26. PMID 18401530 DOI: 10.1111/J.1745-7270.2008.00408.X |
0.749 |
|
| 2008 |
Van Lanen SG, Shen B. Biosynthesis of enediyne antitumor antibiotics. Current Topics in Medicinal Chemistry. 8: 448-59. PMID 18397168 DOI: 10.2174/156802608783955656 |
0.399 |
|
| 2008 |
Luo Y, Lin S, Zhang J, Cooke HA, Bruner SD, Shen B. Regiospecific O-methylation of naphthoic acids catalyzed by NcsB1, an O-methyltransferase involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. The Journal of Biological Chemistry. 283: 14694-702. PMID 18387946 DOI: 10.1074/Jbc.M802206200 |
0.346 |
|
| 2008 |
Chen Y, Luo Y, Ju J, Wendt-Pienkowski E, Rajski SR, Shen B. Identification of fredericamycin E from Streptomyces griseus: Insights into fredericamycin A biosynthesis highlighting carbaspirocycle formation. Journal of Natural Products. 71: 431-7. PMID 18232659 DOI: 10.1021/Np070664N |
0.417 |
|
| 2008 |
Zhang J, Van Lanen SG, Ju J, Liu W, Dorrestein PC, Li W, Kelleher NL, Shen B. A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 105: 1460-5. PMID 18223152 DOI: 10.1073/Pnas.0711625105 |
0.492 |
|
| 2008 |
Van Lanen SG, Lin S, Shen B. Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism. Proceedings of the National Academy of Sciences of the United States of America. 105: 494-9. PMID 18182490 DOI: 10.1073/Pnas.0708750105 |
0.376 |
|
| 2008 |
Montavon TJ, Christianson CV, Festin GM, Shen B, Bruner SD. Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM. Bioorganic & Medicinal Chemistry Letters. 18: 3099-102. PMID 18078753 DOI: 10.1016/J.Bmcl.2007.11.046 |
0.315 |
|
| 2007 |
Christianson CV, Montavon TJ, Festin GM, Cooke HA, Shen B, Bruner SD. The mechanism of MIO-based aminomutases in beta-amino acid biosynthesis. Journal of the American Chemical Society. 129: 15744-5. PMID 18052279 DOI: 10.1021/Ja0762689 |
0.327 |
|
| 2007 |
Ju J, Seo JW, Her Y, Lim SK, Shen B. New lactimidomycin congeners shed insight into lactimidomycin biosynthesis in Streptomyces amphibiosporus. Organic Letters. 9: 5183-6. PMID 17997563 DOI: 10.1021/Ol702249G |
0.338 |
|
| 2007 |
Van Lanen SG, Oh TJ, Liu W, Wendt-Pienkowski E, Shen B. Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis. Journal of the American Chemical Society. 129: 13082-94. PMID 17918933 DOI: 10.1021/Ja073275O |
0.509 |
|
| 2007 |
Lin S, Van Lanen SG, Shen B. Regiospecific chlorination of (S)-beta-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027. Journal of the American Chemical Society. 129: 12432-8. PMID 17887753 DOI: 10.1021/Ja072311G |
0.35 |
|
| 2007 |
Cooke HA, Zhang J, Griffin MA, Nonaka K, Van Lanen SG, Shen B, Bruner SD. Characterization of NcsB2 as a promiscuous naphthoic acid/coenzyme A ligase integral to the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. Journal of the American Chemical Society. 129: 7728-9. PMID 17539640 DOI: 10.1021/Ja071886A |
0.367 |
|
| 2007 |
Christianson CV, Montavon TJ, Van Lanen SG, Shen B, Bruner SD. The structure of L-tyrosine 2,3-aminomutase from the C-1027 enediyne antitumor antibiotic biosynthetic pathway. Biochemistry. 46: 7205-14. PMID 17516659 DOI: 10.1021/Bi7003685 |
0.391 |
|
| 2007 |
Tang GL, Cheng YQ, Shen B. Chain initiation in the leinamycin-producing hybrid nonribosomal peptide/polyketide synthetase from Streptomyces atroolivaceus S-140. Discrete, monofunctional adenylation enzyme and peptidyl carrier protein that directly load D-alanine. The Journal of Biological Chemistry. 282: 20273-82. PMID 17502372 DOI: 10.1074/Jbc.M702814200 |
0.36 |
|
| 2007 |
Guan C, Ju J, Borlee BR, Williamson LL, Shen B, Raffa KF, Handelsman J. Signal mimics derived from a metagenomic analysis of the gypsy moth gut microbiota. Applied and Environmental Microbiology. 73: 3669-76. PMID 17435000 DOI: 10.1128/Aem.02617-06 |
0.32 |
|
| 2007 |
Wang L, Yun BS, George NP, Wendt-Pienkowski E, Galm U, Oh TJ, Coughlin JM, Zhang G, Tao M, Shen B. Glycopeptide antitumor antibiotic zorbamycin from Streptomyces flavoviridis ATCC 21892: strain improvement and structure elucidation. Journal of Natural Products. 70: 402-6. PMID 17311457 DOI: 10.1021/Np060592K |
0.732 |
|
| 2007 |
Kennedy DR, Gawron LS, Ju J, Liu W, Shen B, Beerman TA. Single chemical modifications of the C-1027 enediyne core, a radiomimetic antitumor drug, affect both drug potency and the role of ataxia-telangiectasia mutated in cellular responses to DNA double-strand breaks. Cancer Research. 67: 773-81. PMID 17234789 DOI: 10.1158/0008-5472.Can-06-2893 |
0.388 |
|
| 2007 |
Tao M, Wang L, Wendt-Pienkowski E, George NP, Galm U, Zhang G, Coughlin JM, Shen B. The tallysomycin biosynthetic gene cluster from Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insights into the biosynthesis of the bleomycin family of antitumor antibiotics. Molecular Biosystems. 3: 60-74. PMID 17216057 DOI: 10.1039/B615284H |
0.755 |
|
| 2006 |
Van Lanen SG, Shen B. Progress in combinatorial biosynthesis for drug discovery. Drug Discovery Today. Technologies. 3: 285-92. PMID 24980530 DOI: 10.1016/J.Ddtec.2006.09.014 |
0.37 |
|
| 2006 |
Galm U, Shen B. Expression of biosynthetic gene clusters in heterologous hosts for natural product production and combinatorial biosynthesis. Expert Opinion On Drug Discovery. 1: 409-37. PMID 23495943 DOI: 10.1517/17460441.1.5.409 |
0.386 |
|
| 2006 |
Huang Y, Wendt-Pienkowski E, Shen B. A dedicated phosphopantetheinyl transferase for the fredericamycin polyketide synthase from Streptomyces griseus. The Journal of Biological Chemistry. 281: 29660-8. PMID 16895912 DOI: 10.1074/Jbc.M604895200 |
0.358 |
|
| 2006 |
Dorrestein PC, Van Lanen SG, Li W, Zhao C, Deng Z, Shen B, Kelleher NL. The bifunctional glyceryl transferase/phosphatase OzmB belonging to the HAD superfamily that diverts 1,3-bisphosphoglycerate into polyketide biosynthesis. Journal of the American Chemical Society. 128: 10386-7. PMID 16895402 DOI: 10.1021/Ja0639362 |
0.305 |
|
| 2006 |
Van Lanen SG, Lin S, Dorrestein PC, Kelleher NL, Shen B. Substrate specificity of the adenylation enzyme SgcC1 involved in the biosynthesis of the enediyne antitumor antibiotic C-1027. The Journal of Biological Chemistry. 281: 29633-40. PMID 16887797 DOI: 10.1074/Jbc.M605887200 |
0.332 |
|
| 2006 |
Li W, Ju J, Osada H, Shen B. Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus. Journal of Bacteriology. 188: 4148-52. PMID 16707708 DOI: 10.1128/Jb.00172-06 |
0.378 |
|
| 2006 |
Zhao C, Ju J, Christenson SD, Smith WC, Song D, Zhou X, Shen B, Deng Z. Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning the oxazolomycin biosynthetic gene cluster from Streptomyces albus JA3453. Journal of Bacteriology. 188: 4142-7. PMID 16707707 DOI: 10.1128/Jb.00173-06 |
0.802 |
|
| 2006 |
Van Lanen SG, Shen B. Microbial genomics for the improvement of natural product discovery. Current Opinion in Microbiology. 9: 252-60. PMID 16651020 DOI: 10.1016/J.Mib.2006.04.002 |
0.407 |
|
| 2006 |
Tang GL, Cheng YQ, Shen B. Polyketide chain skipping mechanism in the biosynthesis of the hybrid nonribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140. Journal of Natural Products. 69: 387-93. PMID 16562841 DOI: 10.1021/Np050467T |
0.398 |
|
| 2005 |
Wendt-Pienkowski E, Huang Y, Zhang J, Li B, Jiang H, Kwon H, Hutchinson CR, Shen B. Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus. Journal of the American Chemical Society. 127: 16442-52. PMID 16305230 DOI: 10.1021/Ja054376U |
0.598 |
|
| 2005 |
Ju J, Lim SK, Jiang H, Seo JW, Shen B. Iso-migrastatin congeners from Streptomyces platensis and generation of a glutarimide polyketide library featuring the dorrigocin, lactimidomycin, migrastatin, and NK30424 scaffolds. Journal of the American Chemical Society. 127: 11930-1. PMID 16117518 DOI: 10.1021/Ja053118U |
0.348 |
|
| 2005 |
Van Lanen SG, Dorrestein PC, Christenson SD, Liu W, Ju J, Kelleher NL, Shen B. Biosynthesis of the beta-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring beta-amino acyl-S-carrier protein intermediates. Journal of the American Chemical Society. 127: 11594-5. PMID 16104723 DOI: 10.1021/Ja052871K |
0.783 |
|
| 2005 |
Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B. The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases. Chemistry & Biology. 12: 293-302. PMID 15797213 DOI: 10.1016/J.Chembiol.2004.12.013 |
0.797 |
|
| 2005 |
Ju J, Lim SK, Jiang H, Shen B. Migrastatin and dorrigocins are shunt metabolites of iso-migrastatin. Journal of the American Chemical Society. 127: 1622-3. PMID 15700980 DOI: 10.1021/Ja043808I |
0.354 |
|
| 2005 |
Galm U, Hager MH, Van Lanen SG, Ju J, Thorson JS, Shen B. Antitumor antibiotics: bleomycin, enediynes, and mitomycin. Chemical Reviews. 105: 739-58. PMID 15700963 DOI: 10.1021/Cr030117G |
0.531 |
|
| 2004 |
Tang GL, Cheng YQ, Shen B. Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase. Chemistry & Biology. 11: 33-45. PMID 15112993 DOI: 10.1016/J.Chembiol.2003.12.014 |
0.381 |
|
| 2004 |
Shen B. Accessing natural products by combinatorial biosynthesis Science's Stke : Signal Transduction Knowledge Environment. 2004. PMID 15039491 DOI: 10.1126/Stke.2252004Pe14 |
0.35 |
|
| 2004 |
Murrell JM, Liu W, Shen B. Biochemical characterization of the SgcA1 alpha-D-glucopyranosyl-1-phosphate thymidylyltransferase from the enediyne antitumor antibiotic C-1027 biosynthetic pathway and overexpression of sgcA1 in Streptomyces globisporus to improve C-1027 production. Journal of Natural Products. 67: 206-13. PMID 14987060 DOI: 10.1021/Np0340403 |
0.808 |
|
| 2003 |
Christenson SD, Wu W, Spies MA, Shen B, Toney MD. Kinetic analysis of the 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis. Biochemistry. 42: 12708-18. PMID 14580219 DOI: 10.1021/Bi035223R |
0.759 |
|
| 2003 |
Shen B, Liu W, Nonaka K. Enediyne natural products: biosynthesis and prospect towards engineering novel antitumor agents. Current Medicinal Chemistry. 10: 2317-25. PMID 14529344 DOI: 10.2174/0929867033456701 |
0.496 |
|
| 2003 |
Liu W, Ahlert J, Gao Q, Wendt-Pienkowski E, Shen B, Thorson JS. Rapid PCR amplification of minimal enediyne polyketide synthase cassettes leads to a predictive familial classification model. Proceedings of the National Academy of Sciences of the United States of America. 100: 11959-63. PMID 14528002 DOI: 10.1073/Pnas.2034291100 |
0.64 |
|
| 2003 |
Du L, Chen M, Zhang Y, Shen B. BlmIII and BlmIV nonribosomal peptide synthetase-catalyzed biosynthesis of the bleomycin bithiazole moiety involving both in cis and in trans aminoacylation. Biochemistry. 42: 9731-40. PMID 12911315 DOI: 10.1021/Bi034817R |
0.381 |
|
| 2003 |
Schneider TL, Shen B, Walsh CT. Oxidase domains in epothilone and bleomycin biosynthesis: thiazoline to thiazole oxidation during chain elongation. Biochemistry. 42: 9722-30. PMID 12911314 DOI: 10.1021/Bi034792W |
0.333 |
|
| 2003 |
Christenson SD, Liu W, Toney MD, Shen B. A novel 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis. Journal of the American Chemical Society. 125: 6062-3. PMID 12785829 DOI: 10.1021/Ja034609M |
0.808 |
|
| 2003 |
Shen B. Polyketide biosynthesis beyond the type I, II and III polyketide synthase paradigms Current Opinion in Chemical Biology. 7: 285-295. PMID 12714063 DOI: 10.1016/S1367-5931(03)00020-6 |
0.313 |
|
| 2003 |
Cheng YQ, Tang GL, Shen B. Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 100: 3149-54. PMID 12598647 DOI: 10.1073/Pnas.0537286100 |
0.419 |
|
| 2003 |
Zazopoulos E, Huang K, Staffa A, Liu W, Bachmann BO, Nonaka K, Ahlert J, Thorson JS, Shen B, Farnet CM. A genomics-guided approach for discovering and expressing cryptic metabolic pathways. Nature Biotechnology. 21: 187-90. PMID 12536216 DOI: 10.1038/Nbt784 |
0.659 |
|
| 2002 |
Shen B, Kwon HJ. Macrotetrolide biosynthesis: A novel type II polyketide synthase Chemical Record. 2: 389-396. PMID 12469350 DOI: 10.1002/Tcr.10042 |
0.44 |
|
| 2002 |
Cheng YQ, Tang GL, Shen B. Identification and localization of the gene cluster encoding biosynthesis of the antitumor macrolactam leinamycin in Streptomyces atroolivaceus S-140. Journal of Bacteriology. 184: 7013-24. PMID 12446651 DOI: 10.1128/Jb.184.24.7013-7024.2002 |
0.433 |
|
| 2002 |
Kwon HJ, Smith WC, Scharon AJ, Hwang SH, Kurth MJ, Shen B. C-O bond formation by polyketide synthases. Science (New York, N.Y.). 297: 1327-30. PMID 12193782 DOI: 10.1126/Science.1073175 |
0.637 |
|
| 2002 |
Liu W, Christenson SD, Standage S, Shen B. Biosynthesis of the enediyne antitumor antibiotic C-1027. Science (New York, N.Y.). 297: 1170-3. PMID 12183628 DOI: 10.1126/Science.1072110 |
0.8 |
|
| 2002 |
Shen B, Du L, Sanchez C, Edwards DJ, Chen M, Murrell JM. Cloning and characterization of the bleomycin biosynthetic gene cluster from Streptomyces verticillus ATCC15003. Journal of Natural Products. 65: 422-31. PMID 11908996 DOI: 10.1021/Np010550Q |
0.804 |
|
| 2001 |
Shen B, Du L, Sanchez C, Edwards DJ, Chen M, Murrell JM. The biosynthetic gene cluster for the anticancer drug bleomycin from Streptomyces verticillus ATCC15003 as a model for hybrid peptide-polyketide natural product biosynthesis. Journal of Industrial Microbiology & Biotechnology. 27: 378-85. PMID 11774003 DOI: 10.1038/Sj.Jim.7000194 |
0.793 |
|
| 2001 |
Kwon HJ, Smith WC, Xiang L, Shen B. Cloning and heterologous expression of the macrotetrolide biosynthetic gene cluster revealed a novel polyketide synthase that lacks an acyl carrier protein. Journal of the American Chemical Society. 123: 3385-6. PMID 11457082 DOI: 10.1021/Ja0100827 |
0.637 |
|
| 2001 |
Sánchez C, Du L, Edwards DJ, Toney MD, Shen B. Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillus ATCC15003, the producer of the hybrid peptide-polyketide antitumor drug bleomycin. Chemistry & Biology. 8: 725-38. PMID 11451672 DOI: 10.1016/S1074-5521(01)00047-3 |
0.624 |
|
| 2001 |
Rafanan ER, Le L, Zhao L, Decker H, Shen B. Cloning, sequencing, and heterologous expression of the elmGHIJ genes involved in the biosynthesis of the polyketide antibiotic elloramycin from Streptomyces olivaceus Tü2353. Journal of Natural Products. 64: 444-9. PMID 11325225 DOI: 10.1021/NP010007+ |
0.791 |
|
| 2000 |
Beynon J, Rafanan ER, Shen B, Fisher AJ. Crystallization and preliminary X-ray analysis of tetracenomycin A2 oxygenase: a flavoprotein hydroxylase involved in polyketide biosynthesis. Acta Crystallographica. Section D, Biological Crystallography. 56: 1647-51. PMID 11092935 DOI: 10.1107/S0907444900012695 |
0.773 |
|
| 2000 |
Du L, Sánchez C, Chen M, Edwards DJ, Shen B. The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase. Chemistry & Biology. 7: 623-42. PMID 11048953 DOI: 10.1016/S1074-5521(00)00011-9 |
0.606 |
|
| 2000 |
Smith WC, Xiang L, Shen B. Genetic localization and molecular characterization of the nonS gene required for macrotetrolide biosynthesis in Streptomyces griseus DSM40695. Antimicrobial Agents and Chemotherapy. 44: 1809-17. PMID 10858335 DOI: 10.1128/Aac.44.7.1809-1817.2000 |
0.648 |
|
| 2000 |
Liu W, Shen B. Genes for Production of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus Are Clustered with the cagA Gene That Encodes the C-1027 Apoprotein Antimicrobial Agents and Chemotherapy. 44: 382-392. PMID 10639366 DOI: 10.1128/Aac.44.2.382-392.2000 |
0.511 |
|
| 1999 |
Du L, Shen B. Identification and characterization of a type II peptidyl carrier protein from the bleomycin producer Streptomyces verticillus ATCC 15003. Chemistry & Biology. 6: 507-17. PMID 10421758 DOI: 10.1016/S1074-5521(99)80083-0 |
0.342 |
|
| 1999 |
Shen B, Du L, Sanchez C, Chen M, Edwards DJ. Bleomycin biosynthesis in Streptomyces verticillus ATCC15003: A model of hybrid peptide and polyketide biosynthesis Bioorganic Chemistry. 27: 155-171. DOI: 10.1006/Bioo.1998.1131 |
0.598 |
|
| 1999 |
Thorson JS, Shen B, Whitwam RE, Liu W, Li Y, Ahlert J. Enediyne biosynthesis and self-resistance: A progress report Bioorganic Chemistry. 27: 172-188. DOI: 10.1006/Bioo.1998.1122 |
0.624 |
|
| 1996 |
Shen B, Hutchinson CR. Deciphering the mechanism for the assembly of aromatic polyketides by a bacterial polyketide synthase. Proceedings of the National Academy of Sciences of the United States of America. 93: 6600-4. PMID 8692863 DOI: 10.1073/Pnas.93.13.6600 |
0.561 |
|
| 1995 |
Summers RG, Ali A, Shen B, Wessel WA, Hutchinson CR. Malonyl-coenzyme A:acyl carrier protein acyltransferase of Streptomyces glaucescens: a possible link between fatty acid and polyketide biosynthesis. Biochemistry. 34: 9389-402. PMID 7626609 DOI: 10.1021/Bi00029A015 |
0.592 |
|
| 1995 |
Shen B, Summers RG, Wendt-Pienkowski E, Hutchinson CR. The Streptomyces glaucescens tcmKL polyketide synthase and tcmN polyketide cyclase genes govern the size and shape of aromatic polyketides Journal of the American Chemical Society. 117: 6811-6821. DOI: 10.1021/Ja00131A002 |
0.51 |
|
| 1993 |
Shen B, Hutchinson CR. Tetracenomycin F1 monooxygenase: oxidation of a naphthacenone to a naphthacenequinone in the biosynthesis of tetracenomycin C in Streptomyces glaucescens. Biochemistry. 32: 6656-63. PMID 8329392 DOI: 10.1021/Bi00077A019 |
0.522 |
|
| 1993 |
Shen B, Hutchinson CR. Enzymatic synthesis of a bacterial polyketide from acetyl and malonyl coenzyme A. Science (New York, N.Y.). 262: 1535-40. PMID 8248801 DOI: 10.1126/Science.8248801 |
0.59 |
|
| 1993 |
Shen B, Nakayama H, Hutchinson CR. Isolation and structural elucidation of tetracenomycin F2 and tetracenomycin F1: early intermediates in the biosynthesis of tetracenomycin C in Streptomyces glaucescens. Journal of Natural Products. 56: 1288-93. PMID 8229013 DOI: 10.1021/Np50098A013 |
0.53 |
|
| 1993 |
Shen B, Hutchinson CR. Tetracenomycin F2 cyclase: intramolecular aldol condensation in the biosynthesis of tetracenomycin C in Streptomyces glaucescens. Biochemistry. 32: 11149-54. PMID 8218177 DOI: 10.1021/Bi00092A026 |
0.506 |
|
| 1992 |
Shen B, Summers RG, Gramajo H, Bibb MJ, Hutchinson CR. Purification and characterization of the acyl carrier protein of the Streptomyces glaucescens tetracenomycin C polyketide synthase. Journal of Bacteriology. 174: 3818-21. PMID 1592832 DOI: 10.1128/Jb.174.11.3818-3821.1992 |
0.558 |
|
| 1991 |
Gould SJ, Shen B. Epoxyquinones from 2,5-dihydroxyacetanilide: opposite facial specificity in the epoxidation by enzymes from Streptomyces LL-C10037 and Streptomyces MPP 3051 Journal of the American Chemical Society. 113: 684-686. DOI: 10.1021/Ja00002A052 |
0.549 |
|
| 1990 |
Shen B, Whittle YG, Gould SJ, Keszler DA. Structure and absolute stereochemistry of the epoxyquinol LL-C10037.alpha. and related metabolites from Streptomyces LL-C10037 Journal of Organic Chemistry. 55: 4422-4426. DOI: 10.1021/Jo00301A039 |
0.508 |
|
| Show low-probability matches. |