Orla Hardiman, M.D. - Publications

Affiliations: 
Academic Unit of Neurology Trinity College Dublin, the University of Dublin 

241 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Dukic S, Fasano A, Coffey A, Buxó T, McMackin R, Chipika R, Heverin M, Bede P, Muthuraman M, Lowery M, Carson RG, Hardiman O, Nasseroleslami B. Electroencephalographic β-band oscillations in the sensorimotor network reflect motor symptom severity in amyotrophic lateral sclerosis. European Journal of Neurology. e16201. PMID 38235854 DOI: 10.1111/ene.16201  0.829
2023 Metzger M, Dukic S, McMackin R, Giglia E, Mitchell M, Bista S, Costello E, Peelo C, Tadjine Y, Sirenko V, Plaitano S, Coffey A, McManus L, Farnell Sharp A, Mehra P, ... ... Hardiman O, et al. Functional network dynamics revealed by EEG microstates reflect cognitive decline in amyotrophic lateral sclerosis. Human Brain Mapping. PMID 38087950 DOI: 10.1002/hbm.26536  0.816
2023 Bista S, Coffey A, Fasano A, Buxo T, Mitchell M, Giglia ER, Dukic S, Heverin M, Muthuraman M, Carson RG, Lowery M, Hardiman O, McManus L, Nasseroleslami B. Cortico-muscular coherence in primary lateral sclerosis reveals abnormal cortical engagement during motor function beyond primary motor areas. Cerebral Cortex (New York, N.Y. : 1991). PMID 37143180 DOI: 10.1093/cercor/bhad152  0.807
2023 Adey BN, Cooper-Knock J, Al Khleifat A, Fogh I, van Damme P, Corcia P, Couratier P, Hardiman O, McLaughlin R, Gotkine M, Drory V, Silani V, Ticozzi N, Veldink JH, van den Berg LH, et al. Large-scale analyses of CAV1 and CAV2 suggest their expression is higher in post-mortem ALS brain tissue and affects survival. Frontiers in Cellular Neuroscience. 17: 1112405. PMID 36937187 DOI: 10.3389/fncel.2023.1112405  0.311
2023 Tahedl M, Tan EL, Shing SLH, Chipika RH, Siah WF, Hengeveld JC, Doherty MA, McLaughlin RL, Hardiman O, Finegan E, Bede P. Not a benign motor neuron disease: longitudinal imaging captures relentless motor connectome disintegration in Primary Lateral Sclerosis. European Journal of Neurology. PMID 36739888 DOI: 10.1111/ene.15725  0.326
2022 Chipika RH, Mulkerrin G, Murad A, Lope J, Hardiman O, Bede P. Alterations in somatosensory, visual and auditory pathways in amyotrophic lateral sclerosis: an under-recognised facet of ALS. Journal of Integrative Neuroscience. 21: 88. PMID 35633169 DOI: 10.31083/j.jin2103088  0.303
2022 Tahedl M, Li Hi Shing S, Finegan E, Chipika RH, Lope J, Hardiman O, Bede P. Propagation patterns in motor neuron diseases: Individual and phenotype-associated disease-burden trajectories across the UMN-LMN spectrum of MNDs. Neurobiology of Aging. 109: 78-87. PMID 34656922 DOI: 10.1016/j.neurobiolaging.2021.04.031  0.367
2021 Tahedl M, Li Hi Shing S, Finegan E, Chipika RH, Lope J, Murad A, Hardiman O, Bede P. Imaging data reveal divergent longitudinal trajectories in PLS, ALS and poliomyelitis survivors: Group-level and single-subject traits. Data in Brief. 39: 107484. PMID 34901337 DOI: 10.1016/j.dib.2021.107484  0.345
2021 Dukic S, McMackin R, Costello E, Metzger M, Buxo T, Fasano A, Chipika R, Pinto-Grau M, Schuster C, Hammond M, Heverin M, Coffey A, Broderick M, Iyer PM, Mohr K, ... ... Hardiman O, et al. Resting-state EEG reveals four subphenotypes of amyotrophic lateral sclerosis. Brain : a Journal of Neurology. PMID 34791079 DOI: 10.1093/brain/awab322  0.824
2021 Mahoney CJ, Ahmed RM, Huynh W, Tu S, Rohrer JD, Bedlack RS, Hardiman O, Kiernan MC. Pathophysiology and Treatment of Non-motor Dysfunction in Amyotrophic Lateral Sclerosis. Cns Drugs. PMID 33993457 DOI: 10.1007/s40263-021-00820-1  0.345
2021 McMackin R, Dukic S, Costello E, Pinto-Grau M, McManus L, Broderick M, Chipika R, Iyer PM, Heverin M, Bede P, Muthuraman M, Pender N, Hardiman O, Nasseroleslami B. Cognitive network hyperactivation and motor cortex decline correlate with ALS prognosis. Neurobiology of Aging. 104: 57-70. PMID 33964609 DOI: 10.1016/j.neurobiolaging.2021.03.002  0.798
2021 Finegan E, Shing SLH, Chipika RH, Chang KM, McKenna MC, Doherty MA, Hengeveld JC, Vajda A, Pender N, Donaghy C, Hutchinson S, McLaughlin RL, Hardiman O, Bede P. Extra-motor cerebral changes and manifestations in primary lateral sclerosis. Brain Imaging and Behavior. PMID 33409820 DOI: 10.1007/s11682-020-00421-4  0.363
2021 McMackin R, Dukic S, Costello E, Pinto-Grau M, Keenan O, Fasano A, Buxo T, Heverin M, Reilly RB, Pender N, Hardiman O, Nasseroleslami B. Sustained attention to response task-related beta oscillations relate to performance and provide a functional biomarker in ALS. Journal of Neural Engineering. PMID 33395671 DOI: 10.1088/1741-2552/abd829  0.785
2020 Coffey A, Bista S, Fasano A, Buxo T, Mitchell M, Giglia ER, Dukic S, Fenech M, Barry M, Wade A, Heverin M, Muthuraman M, Carson RG, Lowery M, Hardiman O, et al. Altered supraspinal motor networks in survivors of poliomyelitis: A cortico-muscular coherence study. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. 132: 106-113. PMID 33271481 DOI: 10.1016/j.clinph.2020.10.011  0.678
2020 Finegan E, Siah WF, Shing SLH, Chipika RH, Chang KM, McKenna MC, Doherty MA, Hengeveld JC, Vajda A, Donaghy C, Hutchinson S, McLaughlin RL, Hardiman O, Bede P. Imaging and clinical data indicate considerable disease burden in 'probable' PLS: Patients with UMN symptoms for 2-4 years. Data in Brief. 32: 106247. PMID 32944602 DOI: 10.1016/J.Dib.2020.106247  0.368
2020 Chipika RH, Siah WF, Shing SLH, Finegan E, McKenna MC, Christidi F, Chang KM, Karavasilis E, Vajda A, Hengeveld JC, Doherty MA, Donaghy C, Hutchinson S, McLaughlin RL, Hardiman O, et al. MRI data confirm the selective involvement of thalamic and amygdalar nuclei in amyotrophic lateral sclerosis and primary lateral sclerosis. Data in Brief. 32: 106246. PMID 32944601 DOI: 10.1016/J.Dib.2020.106246  0.444
2020 Pender N, Pinto-Grau M, Hardiman O. Cognitive and behavioural impairment in amyotrophic lateral sclerosis. Current Opinion in Neurology. 33: 649-654. PMID 32833751 DOI: 10.1097/Wco.0000000000000862  0.348
2020 Finegan E, Li Hi Shing S, Siah WF, Chipika RH, Chang KM, McKenna MC, Doherty MA, Hengeveld JC, Vajda A, Donaghy C, Hutchinson S, McLaughlin RL, Hardiman O, Bede P. Evolving diagnostic criteria in primary lateral sclerosis: The clinical and radiological basis of "probable PLS". Journal of the Neurological Sciences. 417: 117052. PMID 32731060 DOI: 10.1016/J.Jns.2020.117052  0.358
2020 Chipika RH, Christidi F, Finegan E, Li Hi Shing S, McKenna MC, Chang KM, Karavasilis E, Doherty MA, Hengeveld JC, Vajda A, Pender N, Hutchinson S, Donaghy C, McLaughlin RL, Hardiman O, et al. Amygdala pathology in amyotrophic lateral sclerosis and primary lateral sclerosis. Journal of the Neurological Sciences. 117039. PMID 32713609 DOI: 10.1016/J.Jns.2020.117039  0.432
2020 van Eijk RPA, Kliest T, McDermott CJ, Roes KCB, Van Damme P, Chio A, Weber M, Ingre C, Corcia P, Povedano M, Reviers E, van Es MA, Al-Chalabi A, Hardiman O, van den Berg LH. TRICALS: creating a highway toward a cure. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-6. PMID 32643415 DOI: 10.1080/21678421.2020.1788092  0.316
2020 Hardiman O, van den Berg LH. The Beginning of Genomic Therapies for ALS. The New England Journal of Medicine. 383: 180-181. PMID 32640137 DOI: 10.1056/Nejme2012930  0.417
2020 Franklin JP, Cooper-Knock J, Baheerathan A, Moll T, Männikkö R, Heverin M, Hardiman O, Shaw PJ, Hanna MG. Concurrent sodium channelopathies and amyotrophic lateral sclerosis supports shared pathogenesis. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-4. PMID 32619119 DOI: 10.1080/21678421.2020.1786128  0.371
2020 Bendotti C, Bonetto V, Pupillo E, Logroscino G, Al-Chalabi A, Lunetta C, Riva N, Mora G, Lauria G, Weishaupt JH, Agosta F, Malaspina A, Basso M, Greensmith L, Van Den Bosch L, ... ... Hardiman O, et al. Focus on the heterogeneity of amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-11. PMID 32583689 DOI: 10.1080/21678421.2020.1779298  0.44
2020 Chipika RH, Finegan E, Li Hi Shing S, McKenna MC, Christidi F, Chang KM, Doherty MA, Hengeveld JC, Vajda A, Pender N, Hutchinson S, Donaghy C, McLaughlin RL, Hardiman O, Bede P. "Switchboard" malfunction in motor neuron diseases: Selective pathology of thalamic nuclei in amyotrophic lateral sclerosis and primary lateral sclerosis. Neuroimage. Clinical. 27: 102300. PMID 32554322 DOI: 10.1016/J.Nicl.2020.102300  0.481
2020 Burke T, Pinto-Grau M, Costello E, Peelo C, Lonergan K, Heverin M, Hardiman O, Pender N. The reading the mind in the eyes test short form (A & B): validation and outcomes in an amyotrophic lateral sclerosis cohort. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-9. PMID 32501122 DOI: 10.1080/21678421.2020.1772824  0.337
2020 McMackin R, Dukic S, Costello E, Pinto-Grau M, Fasano A, Buxo T, Heverin M, Reilly R, Muthuraman M, Pender N, Hardiman O, Nasseroleslami B. Corrigendum to: Localization of Brain Networks Engaged by the Sustained Attention to Response Task Provides Quantitative Markers of Executive Impairment in Amyotrophic Lateral Sclerosis. Cerebral Cortex (New York, N.Y. : 1991). PMID 32436562 DOI: 10.1093/cercor/bhaa152  0.787
2020 Brizzi KT, Bridges JFP, Yersak J, Balas C, Thakur N, Galvin M, Hardiman O, Heatwole C, Ravits J, Simmons Z, Bruijn L, Chan J, Bedlack R, Berry JD. Understanding the needs of people with ALS: a national survey of patients and caregivers. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-9. PMID 32396393 DOI: 10.1080/21678421.2020.1760889  0.336
2020 Shefner JM, Al-Chalabi A, Baker MR, Cui LY, de Carvalho M, Eisen A, Grosskreutz J, Hardiman O, Henderson R, Manuel Matamala J, Mitsumoto H, Paulus W, Simon N, Swash M, Talbot K, et al. A proposal for new diagnostic criteria for ALS. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. PMID 32387049 DOI: 10.1016/J.Clinph.2020.04.005  0.328
2020 McMackin R, Dukic S, Costello E, Pinto-Grau M, Fasano A, Buxo T, Heverin M, Reilly R, Muthuraman M, Pender N, Hardiman O, Nasseroleslami B. Localization of Brain Networks Engaged by the Sustained Attention to Response Task Provides Quantitative Markers of Executive Impairment in Amyotrophic Lateral Sclerosis. Cerebral Cortex (New York, N.Y. : 1991). PMID 32318719 DOI: 10.1093/Cercor/Bhaa076  0.799
2020 Antoniadi AM, Galvin M, Heverin M, Hardiman O, Mooney C. Prediction of caregiver burden in amyotrophic lateral sclerosis: a machine learning approach using random forests applied to a cohort study. Bmj Open. 10: e033109. PMID 32114464 DOI: 10.1136/Bmjopen-2019-033109  0.381
2020 Bede P, Chipika RH, Finegan E, Li Hi Shing S, Chang KM, Doherty MA, Hengeveld JC, Vajda A, Hutchinson S, Donaghy C, McLaughlin RL, Hardiman O. Progressive brainstem pathology in motor neuron diseases: Imaging data from amyotrophic lateral sclerosis and primary lateral sclerosis. Data in Brief. 29: 105229. PMID 32083157 DOI: 10.1016/J.Dib.2020.105229  0.418
2020 Meier JM, van der Burgh HK, Nitert AD, Bede P, de Lange SC, Hardiman O, van den Berg LH, van den Heuvel MP. Connectome-based propagation model in amyotrophic lateral sclerosis. Annals of Neurology. PMID 32072667 DOI: 10.1002/Ana.25706  0.419
2020 Finegan E, Hi Shing SL, Chipika RH, McKenna MC, Doherty MA, Hengeveld JC, Vajda A, Donaghy C, McLaughlin RL, Hutchinson S, Hardiman O, Bede P. Thalamic, hippocampal and basal ganglia pathology in primary lateral sclerosis and amyotrophic lateral sclerosis: Evidence from quantitative imaging data. Data in Brief. 29: 105115. PMID 32055654 DOI: 10.1016/J.Dib.2020.105115  0.361
2019 Costello E, Lonergan K, Madden C, O'Sullivan M, Mays I, Heverin M, Pinto-Grau M, Hardiman O, Pender N. Equivalency and practice effects of alternative versions of the Edinburgh Cognitive and Behavioral ALS Screen (ECAS). Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-6. PMID 31833401 DOI: 10.1080/21678421.2019.1701681  0.31
2019 Tattersall R, Murray D, Heverin M, Rooney J, Tobin K, Vance R, Hardiman O, Meldrum D. Respiratory measurements and airway clearance device prescription over one year in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-8. PMID 31823661 DOI: 10.1080/21678421.2019.1697887  0.317
2019 Finegan E, Li Hi Shing S, Chipika RH, Doherty MA, Hengeveld JC, Vajda A, Donaghy C, Pender N, McLaughlin RL, Hardiman O, Bede P. Widespread subcortical grey matter degeneration in primary lateral sclerosis: a multimodal imaging study with genetic profiling. Neuroimage. Clinical. 24: 102089. PMID 31795059 DOI: 10.1016/J.Nicl.2019.102089  0.456
2019 Bede P, Chipika RH, Finegan E, Li Hi Shing S, Doherty MA, Hengeveld JC, Vajda A, Hutchinson S, Donaghy C, McLaughlin RL, Hardiman O. Brainstem pathology in amyotrophic lateral sclerosis and primary lateral sclerosis: A longitudinal neuroimaging study. Neuroimage. Clinical. 24: 102054. PMID 31711033 DOI: 10.1016/J.Nicl.2019.102054  0.458
2019 Burke T, Wilson O'Raghallaigh J, Maguire S, Galvin M, Heverin M, Hardiman O, Pender N. Group interventions for amyotrophic lateral sclerosis caregivers in Ireland: a randomised controlled trial protocol. Bmj Open. 9: e030684. PMID 31542756 DOI: 10.1136/Bmjopen-2019-030684  0.397
2019 Peters S, Visser AE, D'Ovidio F, Vlaanderen J, Portengen L, Beghi E, Chio A, Logroscino G, Hardiman O, Pupillo E, Veldink JH, Vermeulen R, van den Berg LH. Effect modification of the association between total cigarette smoking and ALS risk by intensity, duration and time-since-quitting: Euro-MOTOR. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 31434759 DOI: 10.1136/Jnnp-2019-320986  0.324
2019 Li Hi Shing S, Chipika RH, Finegan E, Murray D, Hardiman O, Bede P. Post-polio Syndrome: More Than Just a Lower Motor Neuron Disease. Frontiers in Neurology. 10: 773. PMID 31379723 DOI: 10.3389/Fneur.2019.00773  0.346
2019 Dukic S, McMackin R, Buxo T, Fasano A, Chipika R, Pinto-Grau M, Costello E, Schuster C, Hammond M, Heverin M, Coffey A, Broderick M, Iyer PM, Mohr K, Gavin B, ... ... Hardiman O, et al. Patterned functional network disruption in amyotrophic lateral sclerosis. Human Brain Mapping. PMID 31348605 DOI: 10.1002/Hbm.24740  0.826
2019 Ryan M, Heverin M, McLaughlin RL, Hardiman O. Lifetime Risk and Heritability of Amyotrophic Lateral Sclerosis. Jama Neurology. PMID 31329211 DOI: 10.1001/Jamaneurol.2019.2044  0.313
2019 Finegan E, Chipika RH, Li Hi Shing S, Doherty MA, Hengeveld JC, Vajda A, Donaghy C, McLaughlin RL, Pender N, Hardiman O, Bede P. The clinical and radiological profile of primary lateral sclerosis: a population-based study. Journal of Neurology. PMID 31325016 DOI: 10.1007/S00415-019-09473-Z  0.435
2019 Al-Chalabi A, Shaw P, Leigh PN, van den Berg L, Hardiman O, Ludolph A, Aho VV, Sarapohja T, Kuoppamäki M. Oral levosimendan in amyotrophic lateral sclerosis: a phase II multicentre, randomised, double-blind, placebo-controlled trial. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 31315908 DOI: 10.1136/Jnnp-2018-320288  0.309
2019 Murray D, Rooney J, Campion A, Fenton L, Hammond M, Heverin M, Meldrum D, Moloney H, Tattersall R, Hardiman O. Longitudinal analysis of sniff nasal inspiratory pressure assessed using occluded and un-occluded measurement techniques in amyotrophic lateral sclerosis and primary lateral sclerosis. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-9. PMID 31313597 DOI: 10.1080/21678421.2019.1639194  0.371
2019 Dekker AM, Diekstra FP, Pulit SL, Tazelaar GHP, van der Spek RA, van Rheenen W, van Eijk KR, Calvo A, Brunetti M, Damme PV, Robberecht W, Hardiman O, McLaughlin R, Chiò A, Sendtner M, et al. Exome array analysis of rare and low frequency variants in amyotrophic lateral sclerosis. Scientific Reports. 9: 5931. PMID 30976013 DOI: 10.1038/S41598-019-42091-3  0.344
2019 van Eijk RPA, Rooney J, Hardiman O, van den Berg LH. Two heads are better than one: benefits of joint models for ALS trials. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 30975822 DOI: 10.1136/Jnnp-2019-320553  0.344
2019 Finegan E, Chipika RH, Li Hi Shing S, Hardiman O, Bede P. Pathological Crying and Laughing in Motor Neuron Disease: Pathobiology, Screening, Intervention. Frontiers in Neurology. 10: 260. PMID 30949121 DOI: 10.3389/Fneur.2019.00260  0.414
2019 Chipika RH, Finegan E, Li Hi Shing S, Hardiman O, Bede P. Tracking a Fast-Moving Disease: Longitudinal Markers, Monitoring, and Clinical Trial Endpoints in ALS. Frontiers in Neurology. 10: 229. PMID 30941088 DOI: 10.3389/Fneur.2019.00229  0.415
2019 Ryan M, Zaldívar Vaillant T, McLaughlin RL, Doherty MA, Rooney J, Heverin M, Gutierrez J, Lara-Fernández GE, Pita Rodríguez M, Hackembruch J, Perna A, Vazquez MC, Musio M, Ketzoian CN, Logroscino G, ... Hardiman O, et al. Comparison of the clinical and genetic features of amyotrophic lateral sclerosis across Cuban, Uruguayan and Irish clinic-based populations. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 30846540 DOI: 10.1136/Jnnp-2018-319838  0.334
2019 Cooper-Knock J, Moll T, Ramesh T, Castelli L, Beer A, Robins H, Fox I, Niedermoser I, Van Damme P, Moisse M, Robberecht W, Hardiman O, Panades MP, Assialioui A, Mora JS, et al. Mutations in the Glycosyltransferase Domain of GLT8D1 Are Associated with Familial Amyotrophic Lateral Sclerosis. Cell Reports. 26: 2298-2306.e5. PMID 30811981 DOI: 10.1016/J.Celrep.2019.02.006  0.35
2019 McMackin R, Muthuraman M, Groppa S, Babiloni C, Taylor JP, Kiernan MC, Nasseroleslami B, Hardiman O. Measuring network disruption in neurodegenerative diseases: New approaches using signal analysis. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 30760643 DOI: 10.1136/Jnnp-2018-319581  0.814
2019 McMackin R, Bede P, Pender N, Hardiman O, Nasseroleslami B. Neurophysiological markers of network dysfunction in neurodegenerative diseases. Neuroimage. Clinical. 22: 101706. PMID 30738372 DOI: 10.1016/J.Nicl.2019.101706  0.788
2019 McMackin R, Dukic S, Broderick M, Iyer PM, Pinto-Grau M, Mohr K, Chipika R, Coffey A, Buxo T, Schuster C, Gavin B, Heverin M, Bede P, Pender N, Lalor EC, ... ... Hardiman O, et al. Dysfunction of attention switching networks in amyotrophic lateral sclerosis. Neuroimage. Clinical. 22: 101707. PMID 30735860 DOI: 10.1016/J.Nicl.2019.101707  0.81
2019 Kueffner R, Zach N, Bronfeld M, Norel R, Atassi N, Balagurusamy V, Di Camillo B, Chio A, Cudkowicz M, Dillenberger D, Garcia-Garcia J, Hardiman O, Hoff B, Knight J, Leitner ML, et al. Stratification of amyotrophic lateral sclerosis patients: a crowdsourcing approach. Scientific Reports. 9: 690. PMID 30679616 DOI: 10.1038/S41598-018-36873-4  0.352
2019 Finegan E, Chipika RH, Shing SLH, Hardiman O, Bede P. Primary lateral sclerosis: a distinct entity or part of the ALS spectrum? Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-13. PMID 30654671 DOI: 10.1080/21678421.2018.1550518  0.463
2019 Peters S, Visser AE, D'Ovidio F, Beghi E, Chiò A, Logroscino G, Hardiman O, Kromhout H, Huss A, Veldink J, Vermeulen R, van den Berg LH. Electric Shock and Extremely Low-Frequency Magnetic Field Exposure and the Risk of ALS: Euro-MOTOR. American Journal of Epidemiology. PMID 30649156 DOI: 10.1093/Aje/Kwy287  0.316
2018 Hardiman O. Global burden of motor neuron diseases: mind the gaps. The Lancet. Neurology. PMID 30409708 DOI: 10.1016/S1474-4422(18)30398-3  0.374
2018 Tazelaar GHP, Dekker AM, van Vugt JJFA, van der Spek RA, Westeneng HJ, Kool LJBG, Kenna KP, van Rheenen W, Pulit SL, McLaughlin RL, Sproviero W, Iacoangeli A, Hübers A, Brenner D, Morrison KE, ... ... Hardiman O, et al. Association of NIPA1 repeat expansions with amyotrophic lateral sclerosis in a large international cohort. Neurobiology of Aging. PMID 30342764 DOI: 10.1016/J.Neurobiolaging.2018.09.012  0.398
2018 Crockford C, Newton J, Lonergan K, Chiwera T, Booth T, Chandran S, Colville S, Heverin M, Mays I, Pal S, Pender N, Pinto-Grau M, Radakovic R, Shaw CE, Stephenson L, ... ... Hardiman O, et al. ALS-specific cognitive and behavior changes associated with advancing disease stage in ALS. Neurology. PMID 30209236 DOI: 10.1212/Wnl.0000000000006317  0.381
2018 D'Ovidio F, Rooney JPK, Visser AE, Manera U, Beghi E, Logroscino G, Vermeulen RCH, Veldink JH, van den Berg LH, Hardiman O, Chiò A. Association between alcohol exposure and the risk of amyotrophic lateral sclerosis in the Euro-MOTOR study. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 30076269 DOI: 10.1136/Jnnp-2018-318559  0.345
2018 Chiò A, Mazzini L, D'Alfonso S, Corrado L, Canosa A, Moglia C, Manera U, Bersano E, Brunetti M, Barberis M, Veldink JH, van den Berg LH, Pearce N, Sproviero W, McLaughlin R, ... ... Hardiman O, et al. The multistep hypothesis of ALS revisited: The role of genetic mutations. Neurology. PMID 30045958 DOI: 10.1212/Wnl.0000000000005996  0.345
2018 Ryan M, Heverin M, Doherty MA, Davis N, Corr EM, Vajda A, Pender N, McLaughlin R, Hardiman O. Determining the incidence of familiality in ALS: A study of temporal trends in Ireland from 1994 to 2016. Neurology. Genetics. 4: e239. PMID 29845113 DOI: 10.1212/Nxg.0000000000000239  0.31
2018 Pinto-Grau M, Hardiman O, Pender N. The Study of Language in the Amyotrophic Lateral Sclerosis - Frontotemporal Spectrum Disorder: a Systematic Review of Findings and New Perspectives. Neuropsychology Review. PMID 29705950 DOI: 10.1007/S11065-018-9375-7  0.41
2018 Visser AE, Rooney JPK, D'Ovidio F, Westeneng HJ, Vermeulen RCH, Beghi E, Chiò A, Logroscino G, Hardiman O, Veldink JH, van den Berg LH. Multicentre, cross-cultural, population-based, case-control study of physical activity as risk factor for amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 29685899 DOI: 10.1136/Jnnp-2017-317724  0.308
2018 Heiman-Patterson TD, Cudkowicz ME, De Carvalho M, Genge A, Hardiman O, Jackson CE, Lechtzin N, Mitsumoto H, Silani V, Andrews JA, Chen D, Kulke S, Rudnicki SA, van den Berg LH. Understanding the use of NIV in ALS: results of an international ALS specialist survey. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-11. PMID 29661084 DOI: 10.1080/21678421.2018.1457058  0.361
2018 Logroscino G, Marin B, Piccininni M, Arcuti S, Chiò A, Hardiman O, Rooney J, Zoccolella S, Couratier P, Preux PM, Beghi E. Referral bias in ALS epidemiological studies. Plos One. 13: e0195821. PMID 29659621 DOI: 10.1371/Journal.Pone.0195821  0.377
2018 Westeneng HJ, Debray TPA, Visser AE, van Eijk RPA, Rooney JPK, Calvo A, Martin S, McDermott CJ, Thompson AG, Pinto S, Kobeleva X, Rosenbohm A, Stubendorff B, Sommer H, Middelkoop BM, ... ... Hardiman O, et al. Prognosis for patients with amyotrophic lateral sclerosis: development and validation of a personalised prediction model. The Lancet. Neurology. PMID 29598923 DOI: 10.1016/S1474-4422(18)30089-9  0.383
2018 Nicolas A, Kenna KP, Renton AE, Ticozzi N, Faghri F, Chia R, Dominov JA, Kenna BJ, Nalls MA, Keagle P, Rivera AM, van Rheenen W, Murphy NA, van Vugt JJFA, Geiger JT, ... ... Hardiman O, et al. Genome-wide Analyses Identify KIF5A as a Novel ALS Gene. Neuron. 97: 1268-1283.e6. PMID 29566793 DOI: 10.1016/J.Neuron.2018.02.027  0.384
2018 Lechtzin N, Cudkowicz ME, de Carvalho M, Genge A, Hardiman O, Mitsumoto H, Mora JS, Shefner J, Van den Berg LH, Andrews JA. Respiratory measures in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-10. PMID 29566571 DOI: 10.1080/21678421.2018.1452945  0.329
2018 Bede P, Omer T, Finegan E, Chipika RH, Iyer PM, Doherty MA, Vajda A, Pender N, McLaughlin RL, Hutchinson S, Hardiman O. Connectivity-based characterisation of subcortical grey matter pathology in frontotemporal dementia and ALS: a multimodal neuroimaging study. Brain Imaging and Behavior. PMID 29423814 DOI: 10.1007/S11682-018-9837-9  0.47
2018 Andrews JA, Cudkowicz ME, Hardiman O, Meng L, Bian A, Lee J, Wolff AA, Malik FI, Shefner JM. VITALITY-ALS, a phase III trial of tirasemtiv, a selective fast skeletal muscle troponin activator, as a potential treatment for patients with amyotrophic lateral sclerosis: study design and baseline characteristics. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-8. PMID 29402141 DOI: 10.1080/21678421.2018.1426770  0.325
2018 Burke T, Hardiman O, Pinto-Grau M, Lonergan K, Heverin M, Tobin K, Staines A, Galvin M, Pender N. Longitudinal predictors of caregiver burden in amyotrophic lateral sclerosis: a population-based cohort of patient-caregiver dyads. Journal of Neurology. PMID 29396678 DOI: 10.1007/S00415-018-8770-6  0.366
2018 Galvin M, Carney S, Corr B, Mays I, Pender N, Hardiman O. Needs of informal caregivers across the caregiving course in amyotrophic lateral sclerosis: a qualitative analysis. Bmj Open. 8: e018721. PMID 29374665 DOI: 10.1136/Bmjopen-2017-018721  0.361
2017 Van Der Spek RA, Van Rheenen W, Pulit SL, Kenna KP, Ticozzi N, Kooyman M, McLaughlin RL, Moisse M, Van Eijk KR, Van Vugt JJFA, Andersen P, Nazli Basak A, Blair I, De Carvalho M, Chio A, ... ... Hardiman O, et al. Reconsidering the causality of TIA1 mutations in ALS. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-3. PMID 29235362 DOI: 10.1080/21678421.2017.1413118  0.313
2017 Bede P, Hardiman O. Longitudinal structural changes in ALS: a three time-point imaging study of white and gray matter degeneration. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-10. PMID 29214883 DOI: 10.1080/21678421.2017.1407795  0.325
2017 Crockford C, Newton J, Lonergan K, Madden C, Mays I, O'Sullivan M, Costello E, Pinto-Grau M, Vajda A, Heverin M, Pender N, Al-Chalabi A, Hardiman O, Abrahams S. Measuring reliable change in cognition using the Edinburgh Cognitive and Behavioural ALS Screen (ECAS). Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-9. PMID 29214872 DOI: 10.1080/21678421.2017.1407794  0.375
2017 Crockford CJ, Kleynhans M, Wilton E, Radakovic R, Newton J, Niven EH, Al-Chalabi A, Hardiman O, Bak TH, Abrahams S. ECAS A-B-C: alternate forms of the Edinburgh Cognitive and Behavioural ALS Screen. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-8. PMID 29205065 DOI: 10.1080/21678421.2017.1407793  0.361
2017 Nasseroleslami B, Dukic S, Broderick M, Mohr K, Schuster C, Gavin B, McLaughlin R, Heverin M, Vajda A, Iyer PM, Pender N, Bede P, Lalor EC, Hardiman O. Characteristic Increases in EEG Connectivity Correlate With Changes of Structural MRI in Amyotrophic Lateral Sclerosis. Cerebral Cortex (New York, N.Y. : 1991). 1-15. PMID 29136131 DOI: 10.1093/Cercor/Bhx301  0.826
2017 Pupillo E, Poloni M, Bianchi E, Giussani G, Logroscino G, Zoccolella S, Chiò A, Calvo A, Corbo M, Lunetta C, Marin B, Mitchell D, Hardiman O, Rooney J, Stevic Z, et al. Trauma and amyotrophic lateral sclerosis: a european population-based case-control study from the EURALS consortium. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-8. PMID 29063790 DOI: 10.1080/21678421.2017.1386687  0.316
2017 Dukic S, Iyer PM, Mohr K, Hardiman O, Lalor EC, Nasseroleslami B. Estimation of coherence using the median is robust against EEG artefacts. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2017: 3949-3952. PMID 29060761 DOI: 10.1109/EMBC.2017.8037720  0.756
2017 O'Brien M, Burke T, Heverin M, Vajda A, McLaughlin R, Gibbons J, Byrne S, Pinto-Grau M, Elamin M, Pender N, Hardiman O. Clustering of Neuropsychiatric Disease in First-Degree and Second-Degree Relatives of Patients With Amyotrophic Lateral Sclerosis. Jama Neurology. PMID 29049464 DOI: 10.1001/Jamaneurol.2017.2699  0.405
2017 Hardiman O, Al-Chalabi A, Chio A, Corr EM, Logroscino G, Robberecht W, Shaw PJ, Simmons Z, van den Berg LH. Amyotrophic lateral sclerosis. Nature Reviews. Disease Primers. 3: 17071. PMID 28980624 DOI: 10.1038/nrdp.2017.71  0.332
2017 Armon C, Hardiman O. The beginning of precision medicine in ALS? Treatment to fit the genes. Neurology. PMID 28978653 DOI: 10.1212/Wnl.0000000000004612  0.417
2017 Al-Chalabi A, Andersen PM, Chandran S, Chio A, Corcia P, Couratier P, Danielsson O, de Carvalho M, Desnuelle C, Grehl T, Grosskreutz J, Holmøy T, Ingre C, Karlsborg M, Kleveland G, ... ... Hardiman O, et al. July 2017 ENCALS statement on edaravone. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-4. PMID 28975816 DOI: 10.1080/21678421.2017.1369125  0.405
2017 Iyer PM, Mohr K, Broderick M, Gavin B, Burke T, Bede P, Pinto-Grau M, Pender NP, McLaughlin R, Vajda A, Heverin M, Lalor EC, Hardiman O, Nasseroleslami B. Mismatch Negativity as an Indicator of Cognitive Sub-Domain Dysfunction in Amyotrophic Lateral Sclerosis. Frontiers in Neurology. 8: 395. PMID 28861032 DOI: 10.3389/Fneur.2017.00395  0.801
2017 Rooney JPK, Visser AE, D'Ovidio F, Vermeulen R, Beghi E, Chio A, Veldink JH, Logroscino G, van den Berg LH, Hardiman O. A case-control study of hormonal exposures as etiologic factors for ALS in women: Euro-MOTOR. Neurology. PMID 28835399 DOI: 10.1212/Wnl.0000000000004390  0.359
2017 Bede P, Iyer PM, Finegan E, Omer T, Hardiman O. Virtual brain biopsies in amyotrophic lateral sclerosis: Diagnostic classification based on in vivo pathological patterns. Neuroimage. Clinical. 15: 653-658. PMID 28664036 DOI: 10.1016/J.Nicl.2017.06.010  0.336
2017 Turner MR, Al-Chalabi A, Chio A, Hardiman O, Kiernan MC, Rohrer JD, Rowe J, Seeley W, Talbot K. Genetic screening in sporadic ALS and FTD. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 28642287 DOI: 10.1136/Jnnp-2017-315995  0.324
2017 Galvin M, Ryan P, Maguire S, Heverin M, Madden C, Vajda A, Normand C, Hardiman O. The path to specialist multidisciplinary care in amyotrophic lateral sclerosis: A population- based study of consultations, interventions and costs. Plos One. 12: e0179796. PMID 28640860 DOI: 10.1371/Journal.Pone.0179796  0.371
2017 Madill M, McDonagh K, Ma J, Vajda A, McLoughlin P, O'Brien T, Hardiman O, Shen S. Amyotrophic lateral sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms. Molecular Brain. 10: 22. PMID 28610619 DOI: 10.1186/S13041-017-0300-4  0.369
2017 Pinto-Grau M, Costello E, O'Connor S, Elamin M, Burke T, Heverin M, Pender N, Hardiman O. Assessing behavioural changes in ALS: cross-validation of ALS-specific measures. Journal of Neurology. PMID 28600595 DOI: 10.1007/S00415-017-8536-6  0.384
2017 D'Ovidio F, Rooney JPK, Visser AE, Vermeulen RCH, Veldink JH, Van Den Berg LH, Hardiman O, Logroscino G, Chiò A, Beghi E. Critical issues in ALS case-control studies: the case of the Euro-MOTOR study. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-8. PMID 28594593 DOI: 10.1080/21678421.2017.1285939  0.393
2017 Omer T, Finegan E, Hutchinson S, Doherty M, Vajda A, McLaughlin RL, Pender N, Hardiman O, Bede P. Neuroimaging patterns along the ALS-FTD spectrum: a multiparametric imaging study. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-13. PMID 28562080 DOI: 10.1080/21678421.2017.1332077  0.433
2017 Hardiman O, van den Berg LH. Edaravone: a new treatment for ALS on the horizon? The Lancet. Neurology. PMID 28522180 DOI: 10.1016/S1474-4422(17)30163-1  0.327
2017 Burke T, Pinto-Grau M, Lonergan K, Bede P, O'Sullivan M, Heverin M, Vajda A, McLaughlin RL, Pender N, Hardiman O. A Cross-sectional population-based investigation into behavioral change in amyotrophic lateral sclerosis: subphenotypes, staging, cognitive predictors, and survival. Annals of Clinical and Translational Neurology. 4: 305-317. PMID 28491898 DOI: 10.1002/Acn3.407  0.315
2017 Smith BN, Topp SD, Fallini C, Shibata H, Chen HJ, Troakes C, King A, Ticozzi N, Kenna KP, Soragia-Gkazi A, Miller JW, Sato A, Dias DM, Jeon M, Vance C, ... ... Hardiman O, et al. Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis. Science Translational Medicine. 9. PMID 28469040 DOI: 10.1126/Scitranslmed.Aad9157  0.316
2017 Schuster C, Hardiman O, Bede P. Survival prediction in Amyotrophic lateral sclerosis based on MRI measures and clinical characteristics. Bmc Neurology. 17: 73. PMID 28412941 DOI: 10.1186/S12883-017-0854-X  0.341
2017 McLaughlin RL, Schijven D, van Rheenen W, van Eijk KR, O'Brien M, Kahn RS, Ophoff RA, Goris A, Bradley DG, Al-Chalabi A, van den Berg LH, Luykx JJ, Hardiman O, Veldink JH, et al. Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. Nature Communications. 8: 14774. PMID 28322246 DOI: 10.1038/Ncomms14774  0.331
2017 Galvin M, Gaffney R, Corr B, Mays I, Hardiman O. From first symptoms to diagnosis of amyotrophic lateral sclerosis: perspectives of an Irish informal caregiver cohort-a thematic analysis. Bmj Open. 7: e014985. PMID 28320799 DOI: 10.1136/Bmjopen-2016-014985  0.311
2017 Hardiman O, Chalabi AA, Brayne C, Beghi E, van den Berg LH, Chio A, Martin S, Logroscino G, Rooney J. The changing picture of amyotrophic lateral sclerosis: lessons from European registers. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 28285264 DOI: 10.1136/Jnnp-2016-314495  0.349
2017 Burke T, Galvin M, Pinto-Grau M, Lonergan K, Madden C, Mays I, Carney S, Hardiman O, Pender N. Caregivers of patients with amyotrophic lateral sclerosis: investigating quality of life, caregiver burden, service engagement, and patient survival. Journal of Neurology. PMID 28280986 DOI: 10.1007/S00415-017-8448-5  0.338
2017 Vajda A, McLaughlin RL, Heverin M, Thorpe O, Abrahams S, Al-Chalabi A, Hardiman O. Genetic testing in ALS: A survey of current practices. Neurology. PMID 28159885 DOI: 10.1212/Wnl.0000000000003686  0.317
2017 Burke T, Lonergan K, Pinto-Grau M, Elamin M, Bede P, Madden C, Hardiman O, Pender N. Visual encoding, consolidation, and retrieval in amyotrophic lateral sclerosis: executive function as a mediator, and predictor of performance. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-9. PMID 28084080 DOI: 10.1080/21678421.2016.1272615  0.336
2017 Omer T, Nasseroleslami B, Molloy F, Mullins G, Hardiman O. Motor Unit Number Index (MUNIX) of six muscles: normal values and effects of age and gender F1000research. 6. DOI: 10.7490/F1000Research.1113611.1  0.781
2016 Schuster C, Hardiman O, Bede P. Development of an Automated MRI-Based Diagnostic Protocol for Amyotrophic Lateral Sclerosis Using Disease-Specific Pathognomonic Features: A Quantitative Disease-State Classification Study. Plos One. 11: e0167331. PMID 27907080 DOI: 10.1371/Journal.Pone.0167331  0.306
2016 Pinto-Grau M, Burke T, Lonergan K, McHugh C, Mays I, Madden C, Vajda A, Heverin M, Elamin M, Hardiman O, Pender N. Screening for cognitive dysfunction in ALS: validation of the Edinburgh Cognitive and Behavioural ALS Screen (ECAS) using age and education adjusted normative data. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-8. PMID 27894201 DOI: 10.1080/21678421.2016.1249887  0.375
2016 Elamin M, Pinto-Grau M, Burke T, Bede P, Rooney J, O'Sullivan M, Lonergan K, Kirby E, Quinlan E, Breen N, Vajda A, Heverin M, Pender N, Hardiman O. Identifying behavioural changes in ALS: Validation of the Beaumont Behavioural Inventory (BBI). Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-6. PMID 27894191 DOI: 10.1080/21678421.2016.1248976  0.428
2016 Rooney J, Fogh I, Westeneng HJ, Vajda A, McLaughlin R, Heverin M, Jones A, van Eijk R, Calvo A, Mazzini L, Shaw C, Morrison K, Shaw PJ, Robberecht W, Van Damme P, ... ... Hardiman O, et al. C9orf72 expansion differentially affects males with spinal onset amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 27663272 DOI: 10.1136/Jnnp-2016-314093  0.343
2016 Al-Chalabi A, Hardiman O, Kiernan MC, Chiò A, Rix-Brooks B, van den Berg LH. Amyotrophic lateral sclerosis: moving towards a new classification system. The Lancet. Neurology. 15: 1182-94. PMID 27647646 DOI: 10.1016/S1474-4422(16)30199-5  0.335
2016 Galvin M, Corr B, Madden C, Mays I, McQuillan R, Timonen V, Staines A, Hardiman O. Caregiving in ALS - a mixed methods approach to the study of Burden. Bmc Palliative Care. 15: 81. PMID 27596749 DOI: 10.1186/S12904-016-0153-0  0.311
2016 Burke T, Pinto-Grau M, Lonergan K, Elamin M, Bede P, Costello E, Hardiman O, Pender N. Measurement of Social Cognition in Amyotrophic Lateral Sclerosis: A Population Based Study. Plos One. 11: e0160850. PMID 27556398 DOI: 10.1371/Journal.Pone.0160850  0.371
2016 van Rheenen W, Shatunov A, Dekker AM, McLaughlin RL, Diekstra FP, Pulit SL, van der Spek RA, Võsa U, de Jong S, Robinson MR, Yang J, Fogh I, van Doormaal PT, Tazelaar GH, Koppers M, ... ... Hardiman O, et al. Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis. Nature Genetics. 48: 1043-8. PMID 27455348 DOI: 10.1038/Ng.3622  0.329
2016 Kenna KP, van Doormaal PT, Dekker AM, Ticozzi N, Kenna BJ, Diekstra FP, van Rheenen W, van Eijk KR, Jones AR, Keagle P, Shatunov A, Sproviero W, Smith BN, van Es MA, Topp SD, ... ... Hardiman O, et al. NEK1 variants confer susceptibility to amyotrophic lateral sclerosis. Nature Genetics. PMID 27455347 DOI: 10.1038/Ng.3626  0.375
2016 Tobin K, Gilthorpe MS, Rooney J, Heverin M, Vajda A, Staines A, Hardiman O. Age-period-cohort analysis of trends in amyotrophic lateral sclerosis incidence. Journal of Neurology. PMID 27372451 DOI: 10.1007/S00415-016-8215-Z  0.383
2016 Fogh I, Lin K, Tiloca C, Rooney J, Gellera C, Diekstra FP, Ratti A, Shatunov A, van Es MA, Proitsi P, Jones A, Sproviero W, Chiò A, McLaughlin RL, Sorarù G, ... ... Hardiman O, et al. Association of a Locus in the CAMTA1 Gene With Survival in Patients With Sporadic Amyotrophic Lateral Sclerosis. Jama Neurology. PMID 27244217 DOI: 10.1001/Jamaneurol.2016.1114  0.327
2016 Schuster C, Elamin M, Hardiman O, Bede P. The segmental diffusivity profile of amyotrophic lateral sclerosis associated white matter degeneration. European Journal of Neurology. 23: 1361-1371. PMID 27207250 DOI: 10.1111/Ene.13038  0.344
2016 Burke T, Elamin M, Bede P, Pinto-Grau M, Lonergan K, Hardiman O, Pender N. Discordant performance on the 'Reading the Mind in the Eyes' Test, based on disease onset in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-6. PMID 27152765 DOI: 10.1080/21678421.2016.1177088  0.397
2016 Rooney J, Heverin M, Vajda A, Burke T, Galvin M, Tobin K, Elamin M, Staines A, Hardiman O. Survival analysis of geospatial factors in the Irish ALS cohort. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-6. PMID 27145090 DOI: 10.1080/21678421.2016.1179326  0.376
2016 Bede P, Iyer PM, Schuster C, Elamin M, Mclaughlin RL, Kenna K, Hardiman O. The selective anatomical vulnerability of ALS: 'disease-defining' and 'disease-defying' brain regions. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-10. PMID 27087114 DOI: 10.3109/21678421.2016.1173702  0.38
2016 Williams KL, Topp S, Yang S, Smith B, Fifita JA, Warraich ST, Zhang KY, Farrawell N, Vance C, Hu X, Chesi A, Leblond CS, Lee A, Rayner SL, Sundaramoorthy V, ... ... Hardiman O, et al. CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia. Nature Communications. 7: 11253. PMID 27080313 DOI: 10.1038/Ncomms11253  0.356
2016 Janssens AI, Ruytings M, Al-Chalabi A, Chio A, Hardiman O, Mcdermott CJ, Meyer T, Mora G, Van Damme P, Van Den Berg LH, Vanhaecht K, Winkler AS, Sermeus W. A mapping review of international guidance on the management and care of amyotrophic lateral sclerosis (ALS). Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-12. PMID 27078045 DOI: 10.3109/21678421.2016.1167911  0.31
2016 Rutter-Locher Z, Tewkesbury D, Stephenson L, Chio A, Ellis C, Hardiman O, Leigh N, Orrell RW, Veldink JH, Visser AE, Berg LHVd, Swingler R, Shaw C, Pearce N, Al-Chalabi A. Multi-step analysis shows that late onset ALS with slow progression may represent a distinct aetiological subgroup F1000research. 5. DOI: 10.7490/F1000Research.1113415.1  0.38
2015 Bradley WG, Stommel EW, Shi X, Torbick NM, Caller TA, Sabel CE, Rooney JP, Staines A, Hardiman O. Spatial cluster analysis of population amyotrophic lateral sclerosis risk in Ireland. Neurology. 85: 1822-3. PMID 26574539 DOI: 10.1212/01.Wnl.0000473800.89178.A9  0.37
2015 Rooney JP, Tobin K, Crampsie A, Vajda A, Heverin M, McLaughlin R, Staines A, Hardiman O. Social deprivation and population density are not associated with small area risk of amyotrophic lateral sclerosis. Environmental Research. 142: 141-7. PMID 26142719 DOI: 10.1016/J.Envres.2015.06.024  0.324
2015 Iyer PM, Egan C, Pinto-Grau M, Burke T, Elamin M, Nasseroleslami B, Pender N, Lalor EC, Hardiman O. Functional Connectivity Changes in Resting-State EEG as Potential Biomarker for Amyotrophic Lateral Sclerosis. Plos One. 10: e0128682. PMID 26091258 DOI: 10.1371/Journal.Pone.0128682  0.807
2015 McLaughlin RL, Vajda A, Hardiman O. Heritability of Amyotrophic Lateral Sclerosis: Insights From Disparate Numbers. Jama Neurology. PMID 26029874 DOI: 10.1001/Jamaneurol.2014.4049  0.315
2015 Burke T, Elamin M, Galvin M, Hardiman O, Pender N. Caregiver burden in amyotrophic lateral sclerosis: a cross-sectional investigation of predictors. Journal of Neurology. 262: 1526-32. PMID 25904206 DOI: 10.1007/S00415-015-7746-Z  0.331
2015 Rooney J, Vajda A, Heverin M, Elamin M, Crampsie A, McLaughlin R, Staines A, Hardiman O. Spatial cluster analysis of population amyotrophic lateral sclerosis risk in Ireland Neurology. 84: 1537-1544. PMID 25770197 DOI: 10.1212/Wnl.0000000000001477  0.31
2015 McLaughlin RL, Kenna KP, Vajda A, Heverin M, Byrne S, Donaghy CG, Cronin S, Bradley DG, Hardiman O. Homozygosity mapping in an Irish ALS case-control cohort describes local demographic phenomena and points towards potential recessive risk loci. Genomics. 105: 237-41. PMID 25620680 DOI: 10.1016/J.Ygeno.2015.01.002  0.362
2015 Rooney J, Byrne S, Heverin M, Tobin K, Dick A, Donaghy C, Hardiman O. A multidisciplinary clinic approach improves survival in ALS:A comparative study of ALS in Ireland and Northern Ireland Journal of Neurology, Neurosurgery and Psychiatry. 86: 496-501. PMID 25550416 DOI: 10.1136/Jnnp-2014-309601  0.366
2015 Bonini NM, Hardiman O. Ataxin-2 expands insight into the ALS clinical spectrum. Neurology. 84: 224-5. PMID 25527266 DOI: 10.1212/Wnl.0000000000001167  0.392
2015 Agosta F, Al-Chalabi A, Filippi M, Hardiman O, Kaji R, Meininger V, Nakano I, Shaw P, Shefner J, van den Berg LH, Ludolph A. The El Escorial criteria: strengths and weaknesses. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 16: 1-7. PMID 25482030 DOI: 10.3109/21678421.2014.964258  0.359
2015 McLaughlin RL, Kenna KP, Vajda A, Bede P, Elamin M, Cronin S, Donaghy CG, Bradley DG, Hardiman O. Second-generation Irish genome-wide association study for amyotrophic lateral sclerosis. Neurobiology of Aging. 36: 1221.e7-13. PMID 25442119 DOI: 10.1016/J.Neurobiolaging.2014.08.030  0.359
2015 Küffner R, Zach N, Norel R, Hawe J, Schoenfeld D, Wang L, Li G, Fang L, Mackey L, Hardiman O, Cudkowicz M, Sherman A, Ertaylan G, Grosse-Wentrup M, Hothorn T, et al. Crowdsourced analysis of clinical trial data to predict amyotrophic lateral sclerosis progression. Nature Biotechnology. 33: 51-7. PMID 25362243 DOI: 10.1038/Nbt.3051  0.36
2015 Bede P, Elamin M, Byrne S, McLaughlin RL, Kenna K, Vajda A, Fagan A, Bradley DG, Hardiman O. Patterns of cerebral and cerebellar white matter degeneration in ALS. Journal of Neurology, Neurosurgery, and Psychiatry. 86: 468-70. PMID 25053771 DOI: 10.1136/Jnnp-2014-308172  0.442
2015 Galvin M, Madden C, Maguire S, Heverin M, Vajda A, Staines A, Hardiman O. Patient journey to a specialist amyotrophic lateral sclerosis multidisciplinary clinic: An exploratory study Bmc Health Services Research. DOI: 10.1186/S12913-015-1229-X  0.332
2015 Burke T, Healy D, Casey P, Hardiman O, Pender N. Atypical social cognitive processing in premotor Huntington’s disease: a single case study Irish Journal of Psychological Medicine. DOI: 10.1017/Ipm.2015.48  0.358
2014 Smith BN, Ticozzi N, Fallini C, Gkazi AS, Topp S, Kenna KP, Scotter EL, Kost J, Keagle P, Miller JW, Calini D, Vance C, Danielson EW, Troakes C, Tiloca C, ... ... Hardiman O, et al. Exome-wide rare variant analysis identifies TUBA4A mutations associated with familial ALS. Neuron. 84: 324-31. PMID 25374358 DOI: 10.1016/J.Neuron.2014.09.027  0.339
2014 Al-Chalabi A, Calvo A, Chio A, Colville S, Ellis CM, Hardiman O, Heverin M, Howard RS, Huisman MH, Keren N, Leigh PN, Mazzini L, Mora G, Orrell RW, Rooney J, et al. Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study. The Lancet. Neurology. 13: 1108-13. PMID 25300936 DOI: 10.1016/S1474-4422(14)70219-4  0.307
2014 Diekstra FP, Van Deerlin VM, van Swieten JC, Al-Chalabi A, Ludolph AC, Weishaupt JH, Hardiman O, Landers JE, Brown RH, van Es MA, Pasterkamp RJ, Koppers M, Andersen PM, Estrada K, Rivadeneira F, et al. C9orf72 and UNC13A are shared risk loci for amyotrophic lateral sclerosis and frontotemporal dementia: a genome-wide meta-analysis. Annals of Neurology. 76: 120-33. PMID 24931836 DOI: 10.1002/Ana.24198  0.385
2014 Rooney J, Heverin M, Vajda A, Crampsie A, Tobin K, Byrne S, Staines A, Hardiman O. An exploratory spatial analysis of ALS incidence in Ireland over 17.5 years (1995-July 2013). Plos One. 9: e96556. PMID 24867594 DOI: 10.1371/Journal.Pone.0096556  0.341
2014 Pupillo E, Messina P, Giussani G, Logroscino G, Zoccolella S, Chiò A, Calvo A, Corbo M, Lunetta C, Marin B, Hardiman O, Rooney J, Stevic Z, Bandettini Di Poggio M, Filosto M, et al. Physical activity and amyotrophic lateral sclerosis: A European population-based case-control study Annals of Neurology. 75: 708-716. PMID 24706338 DOI: 10.1002/Ana.24150  0.331
2014 Foley G, Timonen V, Hardiman O. Understanding psycho-social processes underpinning engagement with services in motor neurone disease: A qualitative study Palliative Medicine. 28: 318-325. PMID 24637571 DOI: 10.1177/0269216313512013  0.34
2014 Bede P, Hardiman O. Lessons of ALS imaging: Pitfalls and future directions - A critical review. Neuroimage. Clinical. 4: 436-43. PMID 24624329 DOI: 10.1016/J.Nicl.2014.02.011  0.35
2014 Byrne S, Heverin M, Bede P, Elamin M, Hardiman O. Fecundity in ALS Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 15: 204-206. PMID 24479554 DOI: 10.3109/21678421.2013.865237  0.363
2014 Bede P, Elamin M, Byrne S, Hardiman O. Sexual dimorphism in ALS: Exploring gender-specific neuroimaging signatures Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 15: 235-242. PMID 24344910 DOI: 10.3109/21678421.2013.865749  0.334
2014 Murray D, Hardiman O, Meldrum D. Assessment of subjective and motor fatigue in Polio survivors, attending a Postpolio clinic, comparison with healthy controls and an exploration of clinical correlates Physiotherapy Theory and Practice. 30: 229-235. PMID 24328931 DOI: 10.3109/09593985.2013.862890  0.349
2014 Fogh I, Ratti A, Gellera C, Lin K, Tiloca C, Moskvina V, Corrado L, Sorarù G, Cereda C, Corti S, Gentilini D, Calini D, Castellotti B, Mazzini L, Querin G, ... ... Hardiman O, et al. A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis. Human Molecular Genetics. 23: 2220-31. PMID 24256812 DOI: 10.1093/Hmg/Ddt587  0.329
2014 Goris A, van Setten J, Diekstra F, Ripke S, Patsopoulos NA, Sawcer SJ, van Es M, Andersen PM, Melki J, Meininger V, Hardiman O, Landers JE, Brown RH, et al. No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis. Human Molecular Genetics. 23: 1916-22. PMID 24234648 DOI: 10.1093/Hmg/Ddt574  0.334
2014 Byrne S, Heverin M, Elamin M, Walsh C, Hardiman O. Intermediate repeat expansion length in C9orf72 may be pathological in amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 15: 148-150. PMID 24053774 DOI: 10.3109/21678421.2013.838586  0.352
2014 McLaughlin RL, Kenna KP, Vajda A, Byrne S, Bradley DG, Hardiman O. UBQLN2 mutations are not a frequent cause of amyotrophic lateral sclerosis in ireland Neurobiology of Aging. 35: 267.e9-267.e11. PMID 23973441 DOI: 10.1016/J.Neurobiolaging.2013.07.023  0.324
2014 Bede P, Hardiman O. Subcortical gray matter structures: A future biomarker for amyotrophic lateral sclerosis? Future Neurology. 9: 109-111. DOI: 10.2217/Fnl.14.3  0.425
2013 Bede P, Elamin M, Byrne S, McLaughlin RL, Kenna K, Vajda A, Pender N, Bradley DG, Hardiman O. Basal ganglia involvement in amyotrophic lateral sclerosis Neurology. 81: 2107-2115. PMID 24212388 DOI: 10.1212/01.Wnl.0000437313.80913.2C  0.433
2013 Al-Chalabi A, Hardiman O. The epidemiology of ALS: A conspiracy of genes, environment and time Nature Reviews Neurology. 9: 617-628. PMID 24126629 DOI: 10.1038/Nrneurol.2013.203  0.404
2013 Kenna KP, McLaughlin RL, Byrne S, Elamin M, Heverin M, Kenny EM, Cormican P, Morris DW, Donaghy CG, Bradley DG, Hardiman O. Delineating the genetic heterogeneity of ALS using targeted high-throughput sequencing. Journal of Medical Genetics. 50: 776-83. PMID 23881933 DOI: 10.1136/Jmedgenet-2013-101795  0.376
2013 Byrne S, Heverin M, Elamin M, Bede P, Lynch C, Kenna K, MacLaughlin R, Walsh C, Al Chalabi A, Hardiman O. Aggregation of neurologic and neuropsychiatric disease in amyotrophic lateral sclerosis kindreds: a population-based case-control cohort study of familial and sporadic amyotrophic lateral sclerosis. Annals of Neurology. 74: 699-708. PMID 23836460 DOI: 10.1002/Ana.23969  0.376
2013 Bede P, Bokde ALW, Byrne S, Elamin M, McLaughlin RL, Kenna K, Fagan AJ, Pender N, Bradley DG, Hardiman O. Multiparametric MRI study of ALS stratified for the C9orf72 genotype Neurology. 81: 361-369. PMID 23771489 DOI: 10.1212/Wnl.0B013E31829C5Eee  0.428
2013 Factor-Litvak P, Al-Chalabi A, Ascherio A, Bradley W, Chío A, Garruto R, Hardiman O, Kamel F, Kasarskis E, McKee A, Nakano I, Nelson LM, Eisen A. Current pathways for epidemiological research in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 14: 33-43. PMID 23678878 DOI: 10.3109/21678421.2013.778565  0.387
2013 Fournier C, Bedlack B, Hardiman O, Heiman-Patterson T, Gutmann L, Bromberg M, Ostrow L, Carter G, Kabashi E, Bertorini T, Mozaffar T, Andersen P, Dietz J, Gamez J, et al. ALS Untangled No. 20: the Deanna protocol. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 14: 319-23. PMID 23638638 DOI: 10.3109/21678421.2013.788405  0.354
2013 Elamin M, Bede P, Byrne S, Jordan N, Gallagher L, Wynne B, O'Brien C, Phukan J, Lynch C, Pender N, Hardiman O. Cognitive changes predict functional decline in ALS: A population-based longitudinal study Neurology. 80: 1590-1597. PMID 23553481 DOI: 10.1212/Wnl.0B013E31828F18Ac  0.416
2013 Turner MR, Hardiman O, Benatar M, Brooks BR, Chio A, de Carvalho M, Ince PG, Lin C, Miller RG, Mitsumoto H, Nicholson G, Ravits J, Shaw PJ, Swash M, Talbot K, et al. Controversies and priorities in amyotrophic lateral sclerosis. The Lancet. Neurology. 12: 310-22. PMID 23415570 DOI: 10.1016/S1474-4422(13)70036-X  0.421
2013 Byrne S, Pradhan F, Dhubhghaill SN, Treacy M, Cassidy L, Hardiman O. Blink rate in ALS Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 14: 291-293. PMID 23151260 DOI: 10.3109/21678421.2012.729217  0.336
2013 Bede P, Bokde A, Elamin M, Byrne S, McLaughlin RL, Jordan N, Hampel H, Gallagher L, Lynch C, Fagan AJ, Pender N, Hardiman O. Grey matter correlates of clinical variables in amyotrophic lateral sclerosis (ALS): a neuroimaging study of ALS motor phenotype heterogeneity and cortical focality. Journal of Neurology, Neurosurgery, and Psychiatry. 84: 766-73. PMID 23085933 DOI: 10.1136/Jnnp-2012-302674  0.506
2013 van Rheenen W, Diekstra FP, van Doormaal PT, Seelen M, Kenna K, McLaughlin R, Shatunov A, Czell D, van Es MA, van Vught PW, van Damme P, Smith BN, Waibel S, Schelhaas HJ, van der Kooi AJ, ... ... Hardiman O, et al. H63D polymorphism in HFE is not associated with amyotrophic lateral sclerosis. Neurobiology of Aging. 34: 1517.e5-7. PMID 23063643 DOI: 10.1016/J.Neurobiolaging.2012.07.020  0.36
2012 Van Hoecke A, Schoonaert L, Lemmens R, Timmers M, Staats KA, Laird AS, Peeters E, Philips T, Goris A, Dubois B, Andersen PM, Al-Chalabi A, Thijs V, Turnley AM, van Vught PW, ... ... Hardiman O, et al. EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans. Nature Medicine. 18: 1418-22. PMID 22922411 DOI: 10.1038/Nm.2901  0.426
2012 Bedlack R, Hardiman O, Heiman-Patterson T, Gutmann L, Bromberg M, Ostrow L, Carter G, Kabashi E, Bertorini T, Mozaffar T, Andersen P, Dietz J, Gamez J, Dimachkie M, Wang Y, et al. ALS untangled no. 17: "When ALS Is Lyme" Amyotrophic Lateral Sclerosis. 13: 487-491. PMID 22873562 DOI: 10.3109/17482968.2012.717796  0.363
2012 Hardiman O, Figlewicz DA. The expansions of ALS. Neurology. 79: 842-3. PMID 22843260 DOI: 10.1212/Wnl.0B013E3182662031  0.49
2012 Diekstra FP, Saris CG, van Rheenen W, Franke L, Jansen RC, van Es MA, van Vught PW, Blauw HM, Groen EJ, Horvath S, Estrada K, Rivadeneira F, Hofman A, Uitterlinden AG, Robberecht W, ... ... Hardiman O, et al. Mapping of gene expression reveals CYP27A1 as a susceptibility gene for sporadic ALS. Plos One. 7: e35333. PMID 22509407 DOI: 10.1371/Journal.Pone.0035333  0.378
2012 Byrne S, Elamin M, Bede P, Hardiman O. Absence of consensus in diagnostic criteria for familial neurodegenerative diseases Journal of Neurology, Neurosurgery and Psychiatry. 83: 365-367. PMID 22399794 DOI: 10.1136/Jnnp-2011-301530  0.331
2012 Byrne S, Elamin M, Bede P, Shatunov A, Walsh C, Corr B, Heverin M, Jordan N, Kenna K, Lynch C, McLaughlin RL, Iyer PM, O'Brien C, Phukan J, Wynne B, ... ... Hardiman O, et al. Cognitive and clinical characteristics of patients with amyotrophic lateral sclerosis carrying a C9orf72 repeat expansion: A population-based cohort study The Lancet Neurology. 11: 232-240. PMID 22305801 DOI: 10.1016/S1474-4422(12)70014-5  0.456
2012 Hardiman O. Multidisciplinary care in ALS: Expanding the team Amyotrophic Lateral Sclerosis. 13: 165. PMID 22292839 DOI: 10.3109/17482968.2012.657006  0.302
2012 Foley G, Timonen V, Hardiman O. Experience of Services as a Key Outcome in Amyotrophic Lateral Sclerosis (ALS) Care: The Case for a Better Understanding of Patient Experiences American Journal of Hospice and Palliative Medicine. 29: 362-367. PMID 21998444 DOI: 10.1177/1049909111423774  0.305
2012 Andersen PM, Abrahams S, Borasio GD, de Carvalho M, Chio A, Van Damme P, Hardiman O, Kollewe K, Morrison KE, Petri S, Pradat PF, Silani V, Tomik B, Wasner M, et al. EFNS guidelines on the clinical management of amyotrophic lateral sclerosis (MALS)--revised report of an EFNS task force. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 19: 360-75. PMID 21914052 DOI: 10.1111/J.1468-1331.2011.03501.X  0.314
2012 Phukan J, Elamin M, Bede P, Jordan N, Gallagher L, Byrne S, Lynch C, Pender N, Hardiman O. The syndrome of cognitive impairment in amyotrophic lateral sclerosis: A population-based study Journal of Neurology, Neurosurgery and Psychiatry. 83: 102-108. PMID 21836033 DOI: 10.1136/Jnnp-2011-300188  0.374
2012 Al-Chalabi A, Hardiman O. Ask the Experts: Translating amyotrophic lateral sclerosis genetics to the clinic: implications for the patient Neurodegenerative Disease Management. 2: 355-360. DOI: 10.2217/Nmt.12.40  0.335
2012 Elamin M, Bede P, Byrne S, Jordan N, Gallagher L, Lynch C, O'Brien C, Wynne B, Pender N, Hardiman O. Are Cognitive Changes in Amyotrophic Lateral Sclerosis Markers for Distinct Disease Subtypes? A Population-Based Longitudinal Study (S25.007) Neurology. 78. DOI: 10.1212/Wnl.78.1_Meetingabstracts.S25.007  0.438
2012 Byrne S, Shatunov A, Bede P, Elamin M, Lynch C, Kenna K, McLaughlin R, Pender N, Bradley D, Al-Chalabi A, Hardiman O. The Population Based Prevalence and Phenotype of 9p21 Hexanucleotide Repeats in ALS/FTD (IN9-1.005) Neurology. 78: IN9-1.005-IN9-1.005. DOI: 10.1212/Wnl.78.1_Meetingabstracts.In9-1.005  0.398
2011 Bede P, Oliver D, Stodart J, van den Berg L, Simmons Z, Ó Brannagáin D, Borasio GD, Hardiman O. Palliative care in amyotrophic lateral sclerosis: a review of current international guidelines and initiatives. Bmj Supportive & Palliative Care. 1: 343-8. PMID 24653482 DOI: 10.1136/Bmjspcare.2010.232637.Rep  0.32
2011 Hardiman O, Van Den Berg LH, Kiernan MC. Clinical diagnosis and management of amyotrophic lateral sclerosis Nature Reviews Neurology. 7: 639-649. PMID 21989247 DOI: 10.1038/Nrneurol.2011.153  0.401
2011 Geser F, Prvulovic D, O'Dwyer L, Hardiman O, Bede P, Bokde AL, Trojanowski JQ, Hampel H. On the development of markers for pathological TDP-43 in amyotrophic lateral sclerosis with and without dementia. Progress in Neurobiology. 95: 649-62. PMID 21911035 DOI: 10.1016/J.Pneurobio.2011.08.011  0.431
2011 Hardiman O. Amyotrophic lateral sclerosis and vascular risk: A metabolic conundrum Journal of Neurology, Neurosurgery and Psychiatry. 82: 591. PMID 21551170 DOI: 10.1136/Jnnp.2011.241539  0.427
2011 Bede P, Bokde ALW, Byrne SC, Elamin M, Walsh RJ, Hardiman O. Waterskier's Hirayama syndrome Journal of Neurology. 258: 2078-2079. PMID 21503827 DOI: 10.1007/S00415-011-6046-5  0.357
2011 Elamin M, Phukan J, Bede P, Jordan N, Byrne S, Pender N, Hardiman O. Executive dysfunction is a negative prognostic indicator in patients with ALS without dementia Neurology. 76: 1263-1269. PMID 21464431 DOI: 10.1212/Wnl.0B013E318214359F  0.365
2011 Bede P, Oliver D, Stodart J, Van Den Berg L, Simmons Z, Brannagáin DO, Borasio GD, Hardiman O. Palliative care in amyotrophic lateral sclerosis: A review of current international guidelines and initiatives Journal of Neurology, Neurosurgery and Psychiatry. 82: 413-418. PMID 21297150 DOI: 10.1136/Jnnp.2010.232637  0.32
2011 Kiernan MC, Vucic S, Cheah BC, Turner MR, Eisen A, Hardiman O, Burrell JR, Zoing MC. Amyotrophic lateral sclerosis. Lancet. 377: 942-55. PMID 21296405 DOI: 10.1016/S0140-6736(10)61156-7  0.323
2011 Hardiman O. Management of respiratory symptoms in ALS Journal of Neurology. 258: 359-365. PMID 21082322 DOI: 10.1007/S00415-010-5830-Y  0.322
2011 Beghi E, Chiò A, Couratier P, Esteban J, Hardiman O, Logroscino G, Millul A, Mitchell D, Preux PM, Pupillo E, Stevic Z, Swingler R, Traynor BJ, Van den Berg LH, Veldink JH, et al. The epidemiology and treatment of ALS: focus on the heterogeneity of the disease and critical appraisal of therapeutic trials. Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group On Motor Neuron Diseases. 12: 1-10. PMID 20698807 DOI: 10.3109/17482968.2010.502940  0.316
2010 Shatunov A, Mok K, Newhouse S, Weale ME, Smith B, Vance C, Johnson L, Veldink JH, van Es MA, van den Berg LH, Robberecht W, Van Damme P, Hardiman O, Farmer AE, Lewis CM, et al. Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study. The Lancet. Neurology. 9: 986-94. PMID 20801717 DOI: 10.1016/S1474-4422(10)70197-6  0.368
2010 Blauw HM, Al-Chalabi A, Andersen PM, van Vught PWJ, Diekstra FP, van Es MA, Saris CGJ, Groen EJN, van Rheenen W, Koppers M, Slot Rvt, Strengman E, Estrada K, Rivadeneira F, Hofman A, ... ... Hardiman O, et al. A large genome scan for rare CNVs in amyotrophic lateral sclerosis Human Molecular Genetics. 19: 4091-4099. PMID 20685689 DOI: 10.1093/Hmg/Ddq323  0.373
2010 Donaghy C, Clarke J, Patterson C, Kee F, Hardiman O, Patterson V. The epidemiology of motor neuron disease in Northern Ireland using capture-recapture methodology. Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group On Motor Neuron Diseases. 11: 374-8. PMID 20550486 DOI: 10.3109/17482960903329569  0.305
2010 Beghi E, Logroscino G, Chiò A, Hardiman O, Millul A, Mitchell D, Swingler R, Traynor BJ. Amyotrophic lateral sclerosis, physical exercise, trauma and sports: results of a population-based pilot case-control study. Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group On Motor Neuron Diseases. 11: 289-92. PMID 20433412 DOI: 10.3109/17482960903384283  0.308
2010 Yeo L, Lynch C, Hardiman O. Validating population-based registers for ALS: How accurate is death certification? Journal of Neurology. 257: 1235-1239. PMID 20151145 DOI: 10.1007/S00415-010-5494-7  0.396
2010 Donaghy C, Pinnock R, Abrahams S, Cardwell C, Hardiman O, Patterson V, McGivern RC, Gibson JM. Slow saccades in bulbar-onset motor neurone disease Journal of Neurology. 257: 1134-1140. PMID 20146069 DOI: 10.1007/S00415-010-5478-7  0.304
2010 Logroscino G, Traynor BJ, Hardiman O, Chiò A, Mitchell D, Swingler RJ, Millul A, Benn E, Beghi E. Incidence of amyotrophic lateral sclerosis in Europe. Journal of Neurology, Neurosurgery, and Psychiatry. 81: 385-90. PMID 19710046 DOI: 10.1136/Jnnp.2009.183525  0.344
2010 Phukan J, Ali E, Pender NP, Molloy F, Hennessy M, Walsh RJ, Hardiman O. Huntington's disease presenting as amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group On Motor Neuron Diseases. 11: 405-7. PMID 19530012 DOI: 10.1080/17482960903055958  0.371
2010 Phukan J, Hardiman O, Jordan N, Gallagher L, Pender NP. PATU4 A population-based longitudinal study of cognitive and behavioural impairment in amyotrophic lateral sclerosis Journal of Neurology, Neurosurgery, and Psychiatry. 81. DOI: 10.1136/Jnnp.2010.226340.33  0.357
2009 Chiò A, Logroscino G, Hardiman O, Swingler R, Mitchell D, Beghi E, Traynor BG. Prognostic factors in ALS: A critical review. Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group On Motor Neuron Diseases. 10: 310-23. PMID 19922118 DOI: 10.3109/17482960802566824  0.332
2009 Hardiman O. Ten years of the ALS journal. Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group On Motor Neuron Diseases. 10: 257. PMID 19922111 DOI: 10.3109/17482960903363287  0.342
2009 Landers JE, Melki J, Meininger V, Glass JD, van den Berg LH, van Es MA, Sapp PC, van Vught PW, McKenna-Yasek DM, Blauw HM, Cho TJ, Polak M, Shi L, Wills AM, Broom WJ, ... ... Hardiman O, et al. Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences of the United States of America. 106: 9004-9. PMID 19451621 DOI: 10.1073/Pnas.0812937106  0.362
2009 Wills AM, Cronin S, Slowik A, Kasperaviciute D, Van Es MA, Morahan JM, Valdmanis PN, Meininger V, Melki J, Shaw CE, Rouleau GA, Fisher EM, Shaw PJ, Morrison KE, Pamphlett R, ... ... Hardiman O, et al. A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS. Neurology. 73: 16-24. PMID 19321847 DOI: 10.1212/Wnl.0B013E3181A18674  0.316
2009 Donaghy C, Pinnock R, Abrahams S, Cardwell C, Hardiman O, Patterson V, McGivern RC, Gibson JM. Ocular fixation instabilities in motor neurone disease. A marker of frontal lobe dysfunction? Journal of Neurology. 256: 420-6. PMID 19306041 DOI: 10.1007/S00415-009-0109-X  0.369
2009 Phukan J, Hardiman O. The management of amyotrophic lateral sclerosis Journal of Neurology. 256: 176-186. PMID 19224316 DOI: 10.1007/S00415-009-0142-9  0.408
2009 Donaghy C, O'Toole O, Sheehan C, Kee F, Hardiman O, Patterson V. An all-Ireland epidemiological study of MND, 2004-2005 European Journal of Neurology. 16: 148-153. PMID 19087159 DOI: 10.1111/J.1468-1331.2008.02361.X  0.343
2009 Cronin S, Tomik B, Bradley DG, Slowik A, Hardiman O. Screening for replication of genome-wide SNP associations in sporadic ALS European Journal of Human Genetics. 17: 213-218. PMID 18987618 DOI: 10.1038/Ejhg.2008.194  0.313
2009 Fallis BA, Hardiman O. Aggregation of neurodegenerative disease in ALS kindreds Amyotrophic Lateral Sclerosis. 10: 95-98. PMID 18608094 DOI: 10.1080/17482960802209664  0.397
2008 Kieran D, Sebastia J, Greenway MJ, King MA, Connaughton D, Concannon CG, Fenner B, Hardiman O, Prehn JHM. Control of motoneuron survival by angiogenin Journal of Neuroscience. 28: 14056-14061. PMID 19109488 DOI: 10.1523/Jneurosci.3399-08.2008  0.303
2008 Cronin S, Blauw HM, Veldink JH, Van Es MA, Ophoff RA, Bradley DG, van den Berg LH, Hardiman O. Analysis of genome-wide copy number variation in Irish and Dutch ALS populations Human Molecular Genetics. 17: 3392-3398. PMID 18689356 DOI: 10.1093/Hmg/Ddn233  0.372
2008 Meisler MH, Russ C, Montgomery KT, Greenway M, Ennis S, Hardiman O, Figlewicz DA, Quenneville NR, Conibear E, Brown RH. Evaluation of the Golgi trafficking protein VPS54 (wobbler) as a candidate for ALS. Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group On Motor Neuron Diseases. 9: 141-8. PMID 18574757 DOI: 10.1080/17482960801934403  0.375
2008 Logroscino G, Traynor BJ, Hardiman O, Chio' A, Couratier P, Mitchell JD, Swingler RJ, Beghi E. Descriptive epidemiology of amyotrophic lateral sclerosis: new evidence and unsolved issues. Journal of Neurology, Neurosurgery, and Psychiatry. 79: 6-11. PMID 18079297 DOI: 10.1136/Jnnp.2006.104828  0.347
2008 Cronin S, Berger S, Ding J, Schymick JC, Washecka N, Hernandez DG, Greenway MJ, Bradley DG, Traynor BJ, Hardiman O. A genome-wide association study of sporadic ALS in a homogenous Irish population. Human Molecular Genetics. 17: 768-74. PMID 18057069 DOI: 10.1093/Hmg/Ddm361  0.325
2008 Chiò A, Traynor BJ, Swingler R, Mitchell D, Hardiman O, Mora G, Beghi E, Logroscino G. Amyotrophic lateral sclerosis and soccer: a different epidemiological approach strengthen the previous findings. Journal of the Neurological Sciences. 269: 187-8; author reply . PMID 17996254 DOI: 10.1016/J.Jns.2007.10.005  0.311
2008 O'Toole O, Traynor BJ, Brennan P, Sheehan C, Frost E, Corr B, Hardiman O. Epidemiology and clinical features of amyotrophic lateral sclerosis in Ireland between 1995 and 2004. Journal of Neurology, Neurosurgery, and Psychiatry. 79: 30-2. PMID 17634215 DOI: 10.1136/Jnnp.2007.117788  0.388
2007 Beghi E, Mennini T, Bendotti C, Bigini P, Logroscino G, Chiò A, Hardiman O, Mitchell D, Swingler R, Traynor BJ, Al-Chalabi A. The heterogeneity of amyotrophic lateral sclerosis: a possible explanation of treatment failure. Current Medicinal Chemistry. 14: 3185-200. PMID 18220753 DOI: 10.2174/092986707782793862  0.449
2007 Phukan J, Pender NP, Hardiman O. Cognitive impairment in amyotrophic lateral sclerosis Lancet Neurology. 6: 994-1003. PMID 17945153 DOI: 10.1016/S1474-4422(07)70265-X  0.47
2007 Miller R, Bradley W, Cudkowicz M, Hubble J, Meininger V, Mitsumoto H, Moore D, Pohlmann H, Sauer D, Silani V, Strong M, Swash M, Vernotica E, Cashman N, Eisen A, ... ... Hardiman O, et al. Phase II/III randomized trial of TCH346 in patients with ALS Neurology. 69: 776-784. PMID 17709710 DOI: 10.1212/01.Wnl.0000269676.07319.09  0.319
2007 Hosback S, Hardiman O, Nolan CM, Doyle MAC, Gorman G, Lynch C, O'Toole O, Jakeman P. Circulating insulin-like growth factors and related binding proteins are selectively altered in amyotrophic lateral sclerosis and multiple sclerosis Growth Hormone and Igf Research. 17: 472-479. PMID 17697791 DOI: 10.1016/J.Ghir.2007.06.002  0.33
2007 Andersen PM, Borasio GD, Dengler R, Hardiman O, Kollewe K, Leigh PN, Pradat PF, Silani V, Tomik B. Good practice in the management of amyotrophic lateral sclerosis: Clinical guidelines. An evidence-based review with good practice points. EALSC Working Group Amyotrophic Lateral Sclerosis. 8: 195-213. PMID 17653917 DOI: 10.1080/17482960701262376  0.305
2007 Meldrum D, Cahalane E, Conroy R, Guthrie R, Hardiman O. Quantitative assessment of motor fatigue: Normative values and comparison with prior-polio patients Amyotrophic Lateral Sclerosis. 8: 170-176. PMID 17538779 DOI: 10.1080/17482960701223113  0.315
2007 Foley G, O'Mahony P, Hardiman O. Perceptions of quality of life in people with ALS: Effects of coping and health care Amyotrophic Lateral Sclerosis. 8: 164-169. PMID 17538778 DOI: 10.1080/17482960601164532  0.33
2007 Cronin S, Hardiman O, Traynor BJ. Ethnic variation in the incidence of ALS: a systematic review. Neurology. 68: 1002-7. PMID 17389304 DOI: 10.1212/01.Wnl.0000258551.96893.6F  0.327
2007 Schymick JC, Yang Y, Andersen PM, Vonsattel JP, Greenway M, Momeni P, Elder J, Chiò A, Restagno G, Robberecht W, Dahlberg C, Mukherjee O, Goate A, Graff-Radford N, Caselli RJ, ... ... Hardiman O, et al. Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis-frontotemporal dementia phenotypes. Journal of Neurology, Neurosurgery, and Psychiatry. 78: 754-6. PMID 17371905 DOI: 10.1136/Jnnp.2006.109553  0.396
2006 Cronin S, Greenway MJ, Ennis S, Kieran D, Green A, Prehn JHM, Hardiman O. Elevated serum angiogenin levels in ALS Neurology. 67: 1833-1836. PMID 17130418 DOI: 10.1212/01.Wnl.0000244466.46020.47  0.362
2006 Parkinson N, Ince PG, Smith MO, Highley R, Skibinski G, Andersen PM, Morrison KE, Pall HS, Hardiman O, Collinge J, Shaw PJ, Fisher EM. ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B). Neurology. 67: 1074-7. PMID 16807408 DOI: 10.1212/01.Wnl.0000231510.89311.8B  0.43
2006 Greenway MJ, Andersen PM, Russ C, Ennis S, Cashman S, Donaghy C, Patterson V, Swingler R, Kieran D, Prehn J, Morrison KE, Green A, Acharya KR, Brown RH, Hardiman O. ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis. Nature Genetics. 38: 411-3. PMID 16501576 DOI: 10.1038/Ng1742  0.423
2005 Andersen PM, Borasio GD, Dengler R, Hardiman O, Kollewe K, Leigh PN, Pradat PF, Silani V, Tomik B. EFNS task force on management of amyotrophic lateral sclerosis: Guidelines for diagnosing and clinical care of patients and relatives: An evidence-based review with good practice points European Journal of Neurology. 12: 921-938. PMID 16324086 DOI: 10.1111/J.1468-1331.2005.01351.X  0.319
2005 Goodall EF, Greenway MJ, Van Marion I, Carroll CB, Hardiman O, Morrison KE. Association of the H63D polymorphism in the hemochromatosis gene with sporadic ALS Neurology. 65: 934-937. PMID 16186539 DOI: 10.1212/01.Wnl.0000176032.94434.D4  0.346
2004 Greenway MJ, Alexander MD, Ennis S, Traynor BJ, Corr B, Frost E, Green A, Hardiman O. A novel candidate region for ALS on chromosome 14q11.2. Neurology. 63: 1936-8. PMID 15557516 DOI: 10.1212/01.Wnl.0000144344.39103.F6  0.304
2004 Kidney D, Alexander M, Corr B, O'Toole O, Hardiman O. Oropharyngeal dysphagia in amyotrophic lateral sclerosis: Neurological and dysphagia specific rating scales Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 5: 150-153. PMID 15512903 DOI: 10.1080/14660820410019675  0.358
2003 Traynor BJ, Alexander M, Corr B, Frost E, Hardiman O. Effect of a multidisciplinary amyotrophic lateral sclerosis (ALS) clinic on ALS survival: a population based study, 1996-2000. Journal of Neurology, Neurosurgery, and Psychiatry. 74: 1258-61. PMID 12933930 DOI: 10.1136/Jnnp.74.9.1258  0.38
2003 Ryan A, Nor AM, Costigan D, Foley-Nolan D, El-Rafie A, Farrell MA, Hardiman O. Polymyositis masquerading as motor neuron disease. Archives of Neurology. 60: 1001-3. PMID 12873858 DOI: 10.1001/Archneur.60.7.1001  0.374
2003 Traynor BJ, Alexander M, Corr B, Frost E, Hardiman O. An outcome study of riluzole in amyotrophic lateral sclerosis--a population-based study in Ireland, 1996-2000. Journal of Neurology. 250: 473-9. PMID 12700914 DOI: 10.1007/S00415-003-1026-Z  0.367
2002 Hardiman O, Traynor BJ, Corr B, Frost E. Models of care for motor neuron disease: setting standards. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group On Motor Neuron Diseases. 3: 182-5. PMID 12710506 DOI: 10.1080/146608202760839002  0.361
2002 Alexander MD, Traynor BJ, Miller N, Corr B, Frost E, McQuaid S, Brett FM, Green A, Hardiman O. "True" sporadic ALS associated with a novel SOD-1 mutation. Annals of Neurology. 52: 680-3. PMID 12402272 DOI: 10.1002/Ana.10369  0.328
2001 Borasio G, Shaw P, Hardiman O, Ludolph A, Luis MS, Silani V. Standards of palliative care for patients with amyotrophic lateral sclerosis: results of a European survey. Amyotrophic Lateral Sclerosis. 2: 159-164. PMID 11771773 DOI: 10.1080/146608201753275517  0.343
2001 Clarke S, Hickey A, O'Boyle C, Hardiman O. Assessing individual quality of life in amyotrophic lateral sclerosis. Quality of Life Research. 10: 149-158. PMID 11642685 DOI: 10.1023/A:1016704906100  0.378
2000 Hardiman O. Pitfalls in the diagnosis of motor neurone disease. Hospital Medicine. 61: 767-771. PMID 11198744 DOI: 10.12968/Hosp.2000.61.11.1461  0.389
2000 Hardiman O. Symptomatic treatment of respiratory and nutritional failure in amyotrophic lateral sclerosis. Journal of Neurology. 247: 245-251. PMID 10836614 DOI: 10.1007/S004150050578  0.382
2000 Traynor BJ, Codd MB, Corr B, Forde C, Frost E, Hardiman O. Amyotrophic lateral sclerosis mimic syndromes: a population-based study. Archives of Neurology. 57: 109-13. PMID 10634456 DOI: 10.1001/Archneur.57.1.109  0.408
1999 Traynor BJ, Codd MB, Corr B, Forde C, Frost E, Hardiman O. Incidence and prevalence of ALS in Ireland, 1995-1997: a population-based study. Neurology. 52: 504-9. PMID 10025778 DOI: 10.1212/Wnl.52.3.504  0.322
1998 Corr B, Frost E, Traynor BJ, Hardiman O. Service provision for patients with ALS/MND: a cost-effective multidisciplinary approach. Journal of the Neurological Sciences. 160: S141-5. PMID 9851665 DOI: 10.1016/S0022-510X(98)00214-7  0.331
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