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Joie Garfunkle - Publications

Affiliations: 
2009 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
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9 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2011 Mileni M, Garfunkle J, Ezzili C, Cravatt BF, Stevens RC, Boger DL. Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent α-ketoheterocycle inhibitor of fatty acid amide hydrolase. Journal of the American Chemical Society. 133: 4092-100. PMID 21355555 DOI: 10.1021/Ja110877Y  0.475
2010 Shimamura H, Breazzano SP, Garfunkle J, Kimball FS, Trzupek JD, Boger DL. Total synthesis of complestatin: development of a Pd(0)-mediated indole annulation for macrocyclization. Journal of the American Chemical Society. 132: 7776-83. PMID 20469945 DOI: 10.1021/Ja102304P  0.374
2010 Mileni M, Garfunkle J, Ezzili C, Kimball FS, Cravatt BF, Stevens RC, Boger DL. X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase. Journal of Medicinal Chemistry. 53: 230-40. PMID 19924997 DOI: 10.1021/Jm9012196  0.475
2009 Garfunkle J, Kimball FS, Trzupek JD, Takizawa S, Shimamura H, Tomishima M, Boger DL. Total synthesis of chloropeptin II (complestatin) and chloropeptin I. Journal of the American Chemical Society. 131: 16036-8. PMID 19839632 DOI: 10.1021/Ja907193B  0.386
2009 Mileni M, Garfunkle J, DeMartino JK, Cravatt BF, Boger DL, Stevens RC. Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures. Journal of the American Chemical Society. 131: 10497-506. PMID 19722626 DOI: 10.1021/Ja902694N  0.517
2008 Slaymaker IM, Bracey M, Mileni M, Garfunkle J, Cravatt BF, Boger DL, Stevens RC. Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase. Bioorganic & Medicinal Chemistry Letters. 18: 5847-50. PMID 18644727 DOI: 10.1016/J.Bmcl.2008.06.086  0.411
2008 DeMartino JK, Garfunkle J, Hochstatter DG, Cravatt BF, Boger DL. Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase. Bioorganic & Medicinal Chemistry Letters. 18: 5842-6. PMID 18639454 DOI: 10.1016/J.Bmcl.2008.06.084  0.478
2008 Garfunkle J, Ezzili C, Rayl TJ, Hochstatter DG, Hwang I, Boger DL. Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. Journal of Medicinal Chemistry. 51: 4392-403. PMID 18630870 DOI: 10.1021/Jm800136B  0.478
2008 Kimball FS, Romero FA, Ezzili C, Garfunkle J, Rayl TJ, Hochstatter DG, Hwang I, Boger DL. Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase. Journal of Medicinal Chemistry. 51: 937-47. PMID 18247553 DOI: 10.1021/Jm701210Y  0.447
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