Year |
Citation |
Score |
2007 |
Yu Z, Sawkar AR, Kelly JW. Pharmacologic chaperoning as a strategy to treat Gaucher disease. The Febs Journal. 274: 4944-50. PMID 17894779 DOI: 10.1111/J.1742-4658.2007.06042.X |
0.497 |
|
2007 |
Yu Z, Sawkar AR, Whalen LJ, Wong CH, Kelly JW. Isofagomine- and 2,5-anhydro-2,5-imino-D-glucitol-based glucocerebrosidase pharmacological chaperones for Gaucher disease intervention. Journal of Medicinal Chemistry. 50: 94-100. PMID 17201413 DOI: 10.1021/Jm060677I |
0.512 |
|
2006 |
Sawkar AR, Schmitz M, Zimmer KP, Reczek D, Edmunds T, Balch WE, Kelly JW. Chemical chaperones and permissive temperatures alter localization of Gaucher disease associated glucocerebrosidase variants. Acs Chemical Biology. 1: 235-51. PMID 17163678 DOI: 10.1021/Cb600187Q |
0.603 |
|
2006 |
Sawkar AR, D'Haeze W, Kelly JW. Therapeutic strategies to ameliorate lysosomal storage disorders--a focus on Gaucher disease. Cellular and Molecular Life Sciences : Cmls. 63: 1179-92. PMID 16568247 DOI: 10.1007/S00018-005-5437-0 |
0.588 |
|
2005 |
Sawkar AR, Adamski-Werner SL, Cheng WC, Wong CH, Beutler E, Zimmer KP, Kelly JW. Gaucher disease-associated glucocerebrosidases show mutation-dependent chemical chaperoning profiles. Chemistry & Biology. 12: 1235-44. PMID 16298303 DOI: 10.1016/J.Chembiol.2005.09.007 |
0.587 |
|
2005 |
Sekijima Y, Wiseman RL, Matteson J, Hammarström P, Miller SR, Sawkar AR, Balch WE, Kelly JW. The biological and chemical basis for tissue-selective amyloid disease. Cell. 121: 73-85. PMID 15820680 DOI: 10.1016/J.Cell.2005.01.018 |
0.405 |
|
2005 |
Premkumar L, Sawkar AR, Boldin-Adamsky S, Toker L, Silman I, Kelly JW, Futerman AH, Sussman JL. X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease. The Journal of Biological Chemistry. 280: 23815-9. PMID 15817452 DOI: 10.1074/Jbc.M502799200 |
0.48 |
|
2002 |
Sawkar AR, Cheng WC, Beutler E, Wong CH, Balch WE, Kelly JW. Chemical chaperones increase the cellular activity of N370S beta -glucosidase: a therapeutic strategy for Gaucher disease. Proceedings of the National Academy of Sciences of the United States of America. 99: 15428-33. PMID 12434014 DOI: 10.1073/Pnas.192582899 |
0.527 |
|
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