Asha L. Bhakar - Related publications

Massachusetts Institute of Technology, Cambridge, MA, United States 
Metaplasticity, visual system, NMDA receptors, neurotrophins
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Sundar V, Vimal S, Sai Mithlesh MS, Dutta A, Tamizhselvi R, Manickam V. Transcriptional cyclin-dependent kinases as the mediators of inflammation-a review. Gene. 145200. PMID 33031895 DOI: 10.1016/j.gene.2020.145200   
2020 Halkowycz P, Grimshaw CE, Keung W, Tanis P, Proffitt C, Peacock K, de Jong R, Sabat M, Banerjee U, Ermolieff J. Biochemical and Cellular Profile of NIK Inhibitors with Long Residence Times. Slas Discovery : Advancing Life Sciences R & D. 2472555220964450. PMID 33084478 DOI: 10.1177/2472555220964450   
2020 Halkowycz P, Grimshaw CE, Keung W, Tanis P, Proffitt C, Peacock K, de Jong R, Sabat M, Banerjee U, Ermolieff J. Biochemical and Cellular Profile of NIK Inhibitors with Long Residence Times. Slas Discovery : Advancing Life Sciences R & D. 2472555220964450. PMID 33084478 DOI: 10.1177/2472555220964450   
2020 Gillies TE, Pargett M, Silva JM, Teragawa CK, McCormick F, Albeck JG. Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathway. Molecular Systems Biology. 16: e9518. PMID 33073539 DOI: 10.15252/msb.20209518   
2020 Thompson PA, Eam B, Young NP, Fish S, Chen J, Barrera M, Howard H, Sung E, Parra A, Staunton J, Chiang GG, Gerson-Gurwitz A, Wegerski CJ, Nevarez A, Clarine J, et al. Targeting oncogene mRNA translation in B cell malignancies with eFT226, a potent and selective inhibitor of eIF4A1. Molecular Cancer Therapeutics. PMID 33037136 DOI: 10.1158/1535-7163.MCT-19-0973   
2020 Jeong H, Park S, Kim SY, Cho SH, Jeong MS, Kim SR, Seo JB, Kim SH, Kim KN. 1-Cinnamoyltrichilinin from Causes Apoptosis through the p38 MAPK Pathway in HL-60 Human Leukemia Cells. International Journal of Molecular Sciences. 21. PMID 33053881 DOI: 10.3390/ijms21207506   
2020 Im JY, Kim DM, Park H, Kang MJ, Kim DY, Chang KY, Kim BK, Won M. VGLL1 phosphorylation and activation promotes gastric cancer malignancy via TGF-β/ERK/RSK2 signaling. Biochimica Et Biophysica Acta. Molecular Cell Research. 118892. PMID 33069758 DOI: 10.1016/j.bbamcr.2020.118892   
2020 Huang JB, Hsu SP, Pan HY, Chen SD, Chen SF, Lin TK, Liu XP, Li JH, Chen NC, Liou CW, Hsu CY, Chuang HY, Chuang YC. Peroxisome Proliferator-Activated Receptor γ Coactivator 1α Activates Vascular Endothelial Growth Factor That Protects Against Neuronal Cell Death Following Status Epilepticus through PI3K/AKT and MEK/ERK Signaling. International Journal of Molecular Sciences. 21. PMID 33008083 DOI: 10.3390/ijms21197247   
2020 Dai C, Shen L, Jin W, Lv B, Liu P, Wang X, Yin Y, Fu Y, Liang L, Ma Z, Zhang X, Wang Y, Xu D, Chen Z. Physapubescin B enhances the sensitivity of gastric cancer cells to trametinib by inhibiting the STAT3 signaling pathway. Toxicology and Applied Pharmacology. 115273. PMID 33035574 DOI: 10.1016/j.taap.2020.115273   
2020 Xia C, Gong Y, Chong K, Xu Y. Phosphatase OsPP2C27 directly dephosphorylates OsMAPK3 and OsbHLH002 to negatively regulate cold tolerance in rice. Plant, Cell & Environment. PMID 33150964 DOI: 10.1111/pce.13938   
2020 Ren Y, Song X, Tan L, Guo C, Wang M, Liu H, Cao Z, Li Y, Peng C. A Review of the Pharmacological Properties of Psoralen. Frontiers in Pharmacology. 11: 571535. PMID 33013413 DOI: 10.3389/fphar.2020.571535   
2020 Liang Y, Zhang T, Ren L, Jing S, Li Z, Zuo P, Li T, Wang Y, Zhang J, Wei Z. Cucurbitacin IIb induces apoptosis and cell cycle arrest through regulating EGFR/MAPK pathway. Environmental Toxicology and Pharmacology. 103542. PMID 33161110 DOI: 10.1016/j.etap.2020.103542   
2020 Zhang H, Lu S, Xu R, Tang Y, Liu J, Li C, Wei J, Yao R, Zhao X, Wei Q, Ma B. Mechanisms of estradiol-induced EGF-like factor expression and oocyte maturation via G protein-coupled estrogen receptor. Endocrinology. PMID 33068422 DOI: 10.1210/endocr/bqaa190   
2020 Ertosun MG, DİlmaÇ S, Hapİl FZ, TanriÖver G, KÖksoy S, ÖzeŞ ON. Regulation of E2F1 activity via PKA-mediated phosphorylations. Turkish Journal of Biology = Turk Biyoloji Dergisi. 44: 215-229. PMID 33110360 DOI: 10.3906/biy-2003-9   
2020 Zeng H, Qi X, Xu X, Wu Y. TAB1 regulates glycolysis and activation of macrophages in diabetic nephropathy. Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]. PMID 33044562 DOI: 10.1007/s00011-020-01411-4   
2020 Peissert S, Schlosser A, Kendel R, Kuper J, Kisker C. Structural basis for CDK7 activation by MAT1 and Cyclin H. Proceedings of the National Academy of Sciences of the United States of America. PMID 33055219 DOI: 10.1073/pnas.2010885117   
2020 Cho JH, Kim K, Kim SA, Park S, Park BO, Kim JH, Kim SY, Kwon MJ, Han MH, Lee SB, Park BC, Park SG, Kim JH, Kim S. Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathways. Cell Death and Differentiation. PMID 33110214 DOI: 10.1038/s41418-020-00649-z   
2020 Thibeault PE, Ramachandran R. Role of the Helix-8 and C-Terminal Tail in Regulating Proteinase Activated Receptor 2 Signaling. Acs Pharmacology & Translational Science. 3: 868-882. PMID 33073187 DOI: 10.1021/acsptsci.0c00039   
2020 Kang SJ, Lee JW, Song J, Park J, Choi J, Suh KH, Min KH. Synthesis and biological activity of 2-cyanoacrylamide derivatives tethered to imidazopyridine as TAK1 inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 35: 1928-1936. PMID 33086897 DOI: 10.1080/14756366.2020.1833876   
2020 Lee SW, Commisso C. Metabolic regulation of EGFR effector and feedback signaling in pancreatic cancer cells requires K-Ras. Biochemical and Biophysical Research Communications. PMID 32972751 DOI: 10.1016/j.bbrc.2020.09.029   
2020 Kim SY, Hwang S, Choi MK, Park S, Nam KY, Kim I. Molecular mechanisms underlying the effects of the small molecule AMC-04 on apoptosis: Roles of the activating transcription factor 4-C/EBP homologous protein-death receptor 5 pathway. Chemico-Biological Interactions. 109277. PMID 33007289 DOI: 10.1016/j.cbi.2020.109277   
2020 Stern M, McNew JA. A transition to degeneration triggered by oxidative stress in degenerative disorders. Molecular Psychiatry. PMID 33159186 DOI: 10.1038/s41380-020-00943-9   
2020 Gaviraghi M, Rabellino A, Andolfo A, Brand M, Brombin C, Bagnato P, De Feudis G, Raimondi A, Locatelli A, Tosoni D, Mazza D, Gianni L, Tonon G, Yarden Y, Tacchetti C, et al. Direct stimulation of ERBB2 highlights a novel cytostatic signaling pathway driven by the receptor Thr phosphorylation. Scientific Reports. 10: 16906. PMID 33037285 DOI: 10.1038/s41598-020-73835-1   
2020 Makino T, Mizawa M, Yoshihisa Y, Yamamoto S, Tabuchi Y, Miyai M, Hibino T, Sasahara M, Shimizu T. Trichohyalin-like 1 protein plays a crucial role in proliferation and anti-apoptosis of normal human keratinocytes and squamous cell carcinoma cells. Cell Death Discovery. 6: 109. PMID 33133644 DOI: 10.1038/s41420-020-00344-5   
2020 An N, Chen Y, Xing Y, Wu H, Gao X, Chen H, Song K, Li Y, Li X, Yang F, Pan X, He X, Wang X, Li Y, Gao Y, et al. Cardiac CaMKII and Wenxin Keli Prevents Ang II-Induced Cardiomyocyte Hypertrophy by Modulating CnA-NFATc4 and Inflammatory Signaling Pathways in H9c2 Cells. Evidence-Based Complementary and Alternative Medicine : Ecam. 2020: 9502651. PMID 33149757 DOI: 10.1155/2020/9502651   
2020 Da Q, Yan Z, Li Z, Han Z, Ren M, Huang L, Zhang X, Liu J, Wang T. TAK1 is involved in sodium L-lactate-stimulated p38 signaling and promotes apoptosis. Molecular and Cellular Biochemistry. PMID 33111211 DOI: 10.1007/s11010-020-03952-y   
2020 Xue M, Sun H, Xu R, Wang Y, Guo J, Li X, Cheng Y, Xu C, Tang C, Sun B, Chen L. GADD45B Promotes Glucose-Induced Renal Tubular Epithelial-Mesenchymal Transition and Apoptosis the p38 MAPK and JNK Signaling Pathways. Frontiers in Physiology. 11: 1074. PMID 33013461 DOI: 10.3389/fphys.2020.01074   
2020 Kim MJ, Kang YJ, Sung B, Jang JY, Ahn YR, Oh HJ, Choi H, Choi I, Im E, Moon HR, Chung HY, Kim ND. Novel SIRT Inhibitor, MHY2256, Induces Cell Cycle Arrest, Apoptosis, and Autophagic Cell Death in HCT116 Human Colorectal Cancer Cells. Biomolecules & Therapeutics. PMID 33073770 DOI: 10.4062/biomolther.2020.153   
2020 Healy LD, Fernández JA, Mosnier LO, Griffin JH. Activated protein C and PAR1-derived and PAR3-derived peptides are anti-inflammatory by suppressing macrophage NLRP3 inflammasomes. Journal of Thrombosis and Haemostasis : Jth. PMID 33049092 DOI: 10.1111/jth.15133   
2020 Wang F, Feng KR, Zhao JY, Zhang JW, Shi XW, Zhou J, Gao D, Lin GQ, Tian P. Identification of novel STAT3 inhibitors bearing 2-acetyl-7-phenylamino benzofuran scaffold for antitumour study. Bioorganic & Medicinal Chemistry. 28: 115822. PMID 33126089 DOI: 10.1016/j.bmc.2020.115822   
2020 Jin M, Wu L, Chen S, Cai R, Dai Y, Yang H, Tang L, Li Y. Arsenic trioxide enhances the chemotherapeutic efficiency of cisplatin in cholangiocarcinoma cells via inhibiting the 14-3-3ε-mediated survival mechanism. Cell Death Discovery. 6: 92. PMID 33024577 DOI: 10.1038/s41420-020-00330-x   
2020 Maurya VK, Kumar S, Bhatt MLB, Saxena SK. Antiviral activity of traditional medicinal plants from Ayurveda against SARS-CoV-2 infection. Journal of Biomolecular Structure & Dynamics. 1-17. PMID 33073699 DOI: 10.1080/07391102.2020.1832577   
2020 Martinez R, Huang W, Samadani R, Mackowiak B, Centola G, Chen L, Conlon IL, Hom K, Kane MA, Fletcher S, Shapiro P. Mechanistic analysis of an ERK2-interacting compound that inhibits mutant-BRAF expressing melanoma cells by inducing oxidative stress. The Journal of Pharmacology and Experimental Therapeutics. PMID 33109619 DOI: 10.1124/jpet.120.000266   
2020 Sarkar A, Gandhi V. Activation of ATM kinase by ROS generated during ionophore-induced mitophagy in human T and B cell malignancies. Molecular and Cellular Biochemistry. PMID 32996079 DOI: 10.1007/s11010-020-03917-1   
2020 Rabani R, Cossette C, Graham F, Powell WS. Protein kinase C activates NAD kinase in human neutrophils. Free Radical Biology & Medicine. PMID 33011272 DOI: 10.1016/j.freeradbiomed.2020.09.022   
2020 Choi H, Roh J. LH-induced Transcriptional Regulation of Expression in Granulosa Cells Occurs via the cAMP/PKA Pathway and Requires a Putative Sp1 Binding Site. International Journal of Molecular Sciences. 21. PMID 33036290 DOI: 10.3390/ijms21197385   
2020 Lee DS, Kim JE. P2 × 7 Receptor Inhibits Astroglial Autophagy via Regulating FAK- and PHLPP1/2-Mediated AKT-S473 Phosphorylation Following Kainic Acid-Induced Seizures. International Journal of Molecular Sciences. 21. PMID 32899862 DOI: 10.3390/ijms21186476   
2020 Gopallawa I, Lee RJ. Targeting the phosphoinositide-3-kinase/protein kinase B pathway in airway innate immunity. World Journal of Biological Chemistry. 11: 30-51. PMID 33024516 DOI: 10.4331/wjbc.v11.i2.30   
2020 Yan Y, Wang P, Wei Y, Bai Y, Lu Y, Zeng H, Liu G, Reiter RJ, He C, Shi H. The dual interplay of RAV5 in activating nitrate reductases and repressing catalase activity to improve disease resistance in cassava. Plant Biotechnology Journal. PMID 33128298 DOI: 10.1111/pbi.13505   
2020 Chui AJ, Griswold AR, Taabazuing CY, Orth EL, Gai K, Rao SD, Ball DP, Hsiao JC, Bachovchin DA. Activation of the CARD8 Inflammasome Requires a Disordered Region. Cell Reports. 33: 108264. PMID 33053349 DOI: 10.1016/j.celrep.2020.108264   
2020 Lin H, Shi F, Jiang S, Wang Y, Zou J, Ying Y, Huang D, Luo L, Yan X, Luo Z. Metformin attenuates trauma-induced heterotopic ossification via inhibition of Bone Morphogenetic Protein signalling. Journal of Cellular and Molecular Medicine. PMID 33169942 DOI: 10.1111/jcmm.16076   
2020 Nishimori S, Wein MN, Kronenberg HM. PTHrP targets salt-inducible kinases, HDAC4 and HDAC5, to repress chondrocyte hypertrophy in the growth plate. Bone. 142: 115709. PMID 33148508 DOI: 10.1016/j.bone.2020.115709   
2020 Tian Y, Zhao L. Metformin induces apoptosis of melanoma B16 cells via PI3K/Akt/mTOR signaling pathways. Journal of B.U.On. : Official Journal of the Balkan Union of Oncology. 25: 2066-2070. PMID 33099954   
2020 Tsai YF, Chen CY, Lin IW, Leu YL, Yang SC, Syu YT, Chen PJ, Hwang TL. Imperatorin alleviates psoriasiform dermatitis by blocking neutrophil respiratory burst, adhesion, and chemotaxis through selective PDE4 inhibition. Antioxidants & Redox Signaling. PMID 33107318 DOI: 10.1089/ars.2019.7835   
2020 Chen H, Teng Y, Liu Z, Geng F, Chen X, Jiang H, Yang J, Zheng M, Wang Z, Yang L. Molecular Mechanism of Platelet-Derived Growth Factor (PDGF)-BB-Mediated Protection Against MPP Toxicity in SH-SY5Y Cells. Journal of Molecular Neuroscience : Mn. PMID 33165739 DOI: 10.1007/s12031-020-01735-0   
2020 Zhang X, Zhang Y, Ji Z, Wang F, Zhang L, Song M, Li H. Oxidative damage mechanism in Saccharomyces cerevisiae cells exposed to tetrachlorobisphenol A. Environmental Toxicology and Pharmacology. 103507. PMID 33007436 DOI: 10.1016/j.etap.2020.103507   
2020 Pan Y, Liu L, Zhang Q, Shi W, Feng W, Wang J, Wang Q, Li S, Li M. Activation of AMPK suppresses S1P-induced airway smooth muscle cells proliferation and its potential mechanisms. Molecular Immunology. 128: 106-115. PMID 33126079 DOI: 10.1016/j.molimm.2020.09.020   
2020 Soamalala J, Diot S, Pellerano M, Blanquart C, Galibert M, Jullian M, Puget K, Morris MC. Fluorescent peptide biosensor for probing CDK6 activity in lung cancer cell extracts. Chembiochem : a European Journal of Chemical Biology. PMID 33112024 DOI: 10.1002/cbic.202000677   
2020 Park SY, An JM, Seo JT, Seo SR. Y-27632 Induces Neurite Outgrowth by Activating the NOX1-Mediated AKT and PAK1 Phosphorylation Cascades in PC12 Cells. International Journal of Molecular Sciences. 21. PMID 33081375 DOI: 10.3390/ijms21207679   
2020 Song J, Bai J, Wang S, Liu L, Zhao Z. [Effects of Quercetin on Autophagy and Phosphatidylinositol 3-kinase/Protein Kinase B/Mammalian Target of Rapamycin Signaling Pathway in Human Prostate Cancer PC-3 Cells]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae. 42: 578-584. PMID 33131510 DOI: 10.3881/j.issn.1000-503X.12361