| Year |
Citation |
Score |
| 2023 |
Payton M, Belmontes B, Hanestad K, Moriguchi J, Chen K, McCarter JD, Chung G, Ninniri MS, Sun J, Manoukian R, Chambers S, Ho SM, Kurzeja RJM, Edson KZ, Dahal UP, ... ... Bourbeau MP, et al. Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers. Nature Cancer. PMID 38151625 DOI: 10.1038/s43018-023-00699-5 |
0.301 |
|
| 2020 |
Frohn M, Liu L, Siegmund AC, Qian W, Amegadzie A, Chen N, Tan H, Hickman D, Wood S, Wen PH, Bartberger MD, Whittington DA, Allen JR, Bourbeau MP. The development of a structurally distinct series of BACE1 inhibitors via the (Z)-fluoro-olefin amide bioisosteric replacement. Bioorganic & Medicinal Chemistry Letters. 30: 127240. PMID 32527542 DOI: 10.1016/J.Bmcl.2020.127240 |
0.307 |
|
| 2014 |
Bourbeau MP, Ashton KS, Yan J, St Jean DJ. Nonracemic synthesis of GK-GKRP disruptor AMG-3969. The Journal of Organic Chemistry. 79: 3684-7. PMID 24678849 DOI: 10.1021/Jo500336E |
0.341 |
|
| 2014 |
Kocienski P, Bourbeau MP, Ashton KS, Yan J, Jean DJS. Synthesis of GK–GKRP Disruptor AMG-3969 Synfacts. 10: 671-671. DOI: 10.1055/S-0034-1378236 |
0.352 |
|
| 2013 |
Bailis J, Fang L, Orf J, Heller S, Bush T, Bourbeau M, Escobar S, Frohn M, Harrington P, Hsieh F, Pickrell A, Sham K, Siegmund A, Tan H, Zalameda L, et al. Abstract 711: Small molecule compounds that target cell division cycle 7 (Cdc7) kinase inhibit cell proliferation and tumor growth. Cancer Research. 73: 711-711. DOI: 10.1158/1538-7445.Am2013-711 |
0.372 |
|
| 2010 |
Zeng Q, Allen JG, Bourbeau MP, Wang X, Yao G, Tadesse S, Rider JT, Yuan CC, Hong FT, Lee MR, Zhang S, Lofgren JA, Freeman DJ, Yang S, Li C, et al. Azole-based inhibitors of AKT/PKB for the treatment of cancer. Bioorganic & Medicinal Chemistry Letters. 20: 1559-64. PMID 20137943 DOI: 10.1016/J.Bmcl.2010.01.067 |
0.301 |
|
| 2010 |
Zeng Q, Bourbeau MP, Wohlhieter GE, Yao G, Monenschein H, Rider JT, Lee MR, Zhang S, Lofgren J, Freeman D, Li C, Tominey E, Huang X, Hoffman D, Yamane H, et al. 2-Aminothiadiazole inhibitors of AKT1 as potential cancer therapeutics. Bioorganic & Medicinal Chemistry Letters. 20: 1652-6. PMID 20137932 DOI: 10.1016/J.Bmcl.2010.01.046 |
0.312 |
|
| 2006 |
Bourbeau MP, Rider JT. A convenient synthesis of 4-alkyl-5-aminoisoxazoles. Organic Letters. 8: 3679-80. PMID 16898790 DOI: 10.1021/Ol061260+ |
0.313 |
|
| 2006 |
Marshall JA, Mikowski AM, Bourbeau MP, Schaaf GM, Valeriote F. Leptostatin: a synthetic hybrid of the cytotoxic polyketides callystatin A and leptomycin B. Bioorganic & Medicinal Chemistry Letters. 16: 320-3. PMID 16271470 DOI: 10.1016/J.Bmcl.2005.09.084 |
0.344 |
|
| 2003 |
Marshall JA, Bourbeau MP. Synthesis of enantioenriched propargylic alcohols related to polyketide natural products. A comparison of methodologies. Organic Letters. 5: 3197-9. PMID 12943386 DOI: 10.1021/Ol034918H |
0.489 |
|
| 2003 |
Marshall JA, Bourbeau MP. Directed Pd(0)-catalyzed hydrostannations of internal alkynes Tetrahedron Letters. 44: 1087-1089. DOI: 10.1016/S0040-4039(02)02660-6 |
0.4 |
|
| 2002 |
Marshall JA, Bourbeau MP. Second-generation synthesis of the polypropionate subunit of callystatin A based on regioselective internal alkyne hydrostannation. Organic Letters. 4: 3931-4. PMID 12599495 DOI: 10.1021/Ol026791M |
0.473 |
|
| 2002 |
Marshall JA, Bourbeau MP. Total synthesis of (-)-callystatin A. The Journal of Organic Chemistry. 67: 2751-4. PMID 11975524 DOI: 10.1021/Jo016025D |
0.463 |
|
| Low-probability matches (unlikely to be authored by this person) |
| 2010 |
Subramanian R, Lee MR, Allen JG, Bourbeau MP, Fotsch C, Hong FT, Tadesse S, Yao G, Yuan CC, Surapaneni S, Skiles GL, Wang X, Wohlhieter GE, Zeng Q, Zhou Y, et al. Cytochrome P450-mediated epoxidation of 2-aminothiazole-based AKT inhibitors: identification of novel GSH adducts and reduction of metabolic activation through structural changes guided by in silico and in vitro screening. Chemical Research in Toxicology. 23: 653-63. PMID 20095585 DOI: 10.1021/Tx900414G |
0.295 |
|
| 2013 |
Bourbeau MP, Siegmund A, Allen JG, Shu H, Fotsch C, Bartberger MD, Kim KW, Komorowski R, Graham M, Busby J, Wang M, Meyer J, Xu Y, Salyers K, Fielden M, et al. Piperazine oxadiazole inhibitors of acetyl-CoA carboxylase. Journal of Medicinal Chemistry. 56: 10132-41. PMID 24294923 DOI: 10.1021/Jm401601S |
0.289 |
|
| 2022 |
Tamayo NA, Bourbeau MP, Allen JR, Ashton KS, Chen JJ, Kaller MR, Nguyen TT, Nishimura N, Pettus LH, Walton M, Belmontes B, Moriguchi J, Chen K, McCarter JD, Hanestad K, et al. Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe. Journal of Medicinal Chemistry. PMID 35286090 DOI: 10.1021/acs.jmedchem.1c02030 |
0.284 |
|
| 2015 |
Bourbeau MP, Bartberger MD. Recent advances in the development of acetyl-CoA carboxylase (ACC) inhibitors for the treatment of metabolic disease. Journal of Medicinal Chemistry. 58: 525-36. PMID 25333641 DOI: 10.1021/Jm500695E |
0.279 |
|
| 2010 |
Bourbeau MP, Allen JG, Gu W. Recent Advances in Acetyl-CoA Carboxylase Inhibitors Annual Reports in Medicinal Chemistry. 45: 95-108. DOI: 10.1016/S0065-7743(10)45006-X |
0.279 |
|
| 2019 |
Pettus LH, Bourbeau MP, Bradley J, Bartberger MD, Chen K, Hickman D, Johnson M, Liu Q, Manning JR, Nanez A, Siegmund A, Wen PH, Whittington DA, Allen JR, Wood S. The Discovery of AM-6494: A Potent and Orally Efficacious β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in vivo Selectivity over BACE2. Journal of Medicinal Chemistry. PMID 31589043 DOI: 10.1021/Acs.Jmedchem.9B01034 |
0.265 |
|
| 2014 |
Hu E, Chen N, Bourbeau MP, Harrington PE, Biswas K, Kunz RK, Andrews KL, Chmait S, Zhao X, Davis C, Ma J, Shi J, Lester-Zeiner D, Danao J, Able J, et al. Discovery of clinical candidate 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A). Journal of Medicinal Chemistry. 57: 6632-41. PMID 25062128 DOI: 10.1021/Jm500713J |
0.254 |
|
| 2015 |
Pennington LD, Bartberger MD, Croghan MD, Andrews KL, Ashton KS, Bourbeau MP, Chen J, Chmait S, Cupples R, Fotsch C, Helmering J, Hong FT, Hungate RW, Jordan SR, Kong K, et al. Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N→S (nN→σ*S-X) Interaction for Conformational Constraint. Journal of Medicinal Chemistry. PMID 26551034 DOI: 10.1021/Acs.Jmedchem.5B01367 |
0.25 |
|
| 2009 |
Allen JG, Bourbeau MP, Wohlhieter GE, Bartberger MD, Michelsen K, Hungate R, Gadwood RC, Gaston RD, Evans B, Mann LW, Matison ME, Schneider S, Huang X, Yu D, Andrews PS, et al. Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction. Journal of Medicinal Chemistry. 52: 7044-53. PMID 19856920 DOI: 10.1021/Jm900681H |
0.248 |
|
| 2013 |
Harrington PE, Bourbeau MP, Fotsch C, Frohn M, Pickrell AJ, Reichelt A, Sham K, Siegmund AC, Bailis JM, Bush T, Escobar S, Hickman D, Heller S, Hsieh F, Orf JN, et al. The optimization of aminooxadiazoles as orally active inhibitors of Cdc7. Bioorganic & Medicinal Chemistry Letters. 23: 6396-400. PMID 24120542 DOI: 10.1016/J.Bmcl.2013.09.055 |
0.248 |
|
| 2006 |
van Heeswijk RP, Bourbeau M, Campbell P, Seguin I, Chauhan BM, Foster BC, Cameron DW. Time-dependent interaction between lopinavir/ritonavir and fexofenadine. Journal of Clinical Pharmacology. 46: 758-67. PMID 16809801 DOI: 10.1177/0091270006288733 |
0.057 |
|
| 2012 |
Sheehan NL, van Heeswijk RP, Foster BC, Akhtar H, Singhal N, Seguin I, DelBalso L, Bourbeau M, Chauhan BM, Boulassel MR, Burger DM, Lalonde RG, Cameron DW. The effect of β-carotene supplementation on the pharmacokinetics of nelfinavir and its active metabolite M8 in HIV-1-infected patients. Molecules (Basel, Switzerland). 17: 688-702. PMID 22241465 DOI: 10.3390/Molecules17010688 |
0.041 |
|
| 2010 |
Varghese RS, Cheema A, Cheema P, Bourbeau M, Tuli L, Zhou B, Jung M, Dritschilo A, Ressom HW. Analysis of LC-MS data for characterizing the metabolic changes in response to radiation. Journal of Proteome Research. 9: 2786-93. PMID 20329776 DOI: 10.1021/pr100185b |
0.02 |
|
| 2005 |
van Heeswijk RP, Bourbeau M, Seguin I, Giguere P, Garber GE, Cameron DW. Absence of circadian variation in the pharmacokinetics of lopinavir/ritonavir given as a once daily dosing regimen in HIV-1-infected patients. British Journal of Clinical Pharmacology. 59: 398-404. PMID 15801934 DOI: 10.1111/j.1365-2125.2005.02337.x |
0.015 |
|
| 2004 |
van Heeswijk RP, Khaliq Y, Gallicano KD, Bourbeau M, Seguin I, Phillips EJ, Cameron DW. The pharmacokinetics of nelfinavir and M8 during pregnancy and post partum. Clinical Pharmacology and Therapeutics. 76: 588-97. PMID 15592330 DOI: 10.1016/j.clpt.2004.08.011 |
0.01 |
|
| Hide low-probability matches. |