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D. Borden Lacy, Ph.D. - Publications

Affiliations: 
1990-1994 University of North Carolina, Chapel Hill, Chapel Hill, NC 
 1994-1999 University of California, Berkeley, Berkeley, CA, United States 
 2006- Vanderbilt University, Nashville, TN 
Area:
Chemistry of bacterial protein toxins
Website:
https://www.vumc.org/lacy-lab
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196 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Kordus SL, Kroh HK, Rodríguez RC, Shrem RA, Peritore-Galve FC, Shupe JA, Wadzinski BE, Lacy DB, Spiller BW. Nanobodies against C. difficile TcdA and TcdB reveal unexpected neutralizing epitopes and provide a toolkit for toxin quantitation in vivo. Plos Pathogens. 19: e1011496. PMID 37871122 DOI: 10.1371/journal.ppat.1011496  0.715
2023 Childress KO, Cencer CS, Tyska MJ, Lacy DB. Nectin-3 and shed forms of CSPG4 can serve as epithelial cell receptors for TcdB. Mbio. e0185723. PMID 37747247 DOI: 10.1128/mbio.01857-23  0.794
2023 Soto Ocaña J, Bayard NU, Hart JL, Thomas AK, Furth EE, Lacy DB, Aronoff DM, Zackular JP. Nonsteroidal anti-inflammatory drugs sensitize epithelial cells to toxin-mediated mitochondrial damage. Science Advances. 9: eadh5552. PMID 37467340 DOI: 10.1126/sciadv.adh5552  0.329
2023 Peritore-Galve FC, Kaji I, Smith A, Walker LM, Shupe JA, Washington MK, Algood HMS, Dudeja PK, Goldenring JR, Lacy DB. Increased intestinal permeability and downregulation of absorptive ion transporters , , and contribute to diarrhea during infection. Gut Microbes. 15: 2225841. PMID 37350393 DOI: 10.1080/19490976.2023.2225841  0.302
2023 Lacy D, Abhyankar PC. Dinuclear Mn(I) Complexes with Phosphido and Hydrido Bridges: Synthesis, Reactivity, and Hydrogenative Catalysis. Chemistry (Weinheim An Der Bergstrasse, Germany). e202300518. PMID 37078974 DOI: 10.1002/chem.202300518  0.206
2023 Lunnemann HM, Shealy NG, Reyzer ML, Shupe JA, Green EH, Siddiqi U, Lacy DB, Byndloss MX, Markham NO. Cecum axis (CecAx) preservation reveals physiological and pathological gradients in mouse gastrointestinal epithelium. Gut Microbes. 15: 2185029. PMID 36872510 DOI: 10.1080/19490976.2023.2185029  0.335
2022 Castro-Córdova P, Otto-Medina M, Montes-Bravo N, Brito-Silva C, Lacy DB, Paredes-Sabja D. Redistribution of the Novel Clostridioides difficile Spore Adherence Receptor E-Cadherin by TcdA and TcdB Increases Spore Binding to Adherens Junctions. Infection and Immunity. e0047622. PMID 36448839 DOI: 10.1128/iai.00476-22  0.338
2022 Bernard SC, Washington MK, Lacy DB. Paeniclostridium sordellii uterine infection is dependent on the estrous cycle. Plos Pathogens. 18: e1010997. PMID 36409774 DOI: 10.1371/journal.ppat.1010997  0.38
2022 Sheedlo MJ, Ohi MD, Lacy DB, Cover TL. Molecular architecture of bacterial type IV secretion systems. Plos Pathogens. 18: e1010720. PMID 35951533 DOI: 10.1371/journal.ppat.1010720  0.757
2022 Saund K, Pirani A, Lacy DB, Hanna PC, Snitkin E. Strain Variation in Clostridioides difficile Cytotoxicity Associated with Genomic Variation at Both Pathogenic and Nonpathogenic Loci. Msphere. 7: e0017422. PMID 35766503 DOI: 10.1128/msphere.00174-22  0.286
2022 Abhyankar PC, MacMillan SN, Lacy D. Bench-Stable Dinuclear Mn(I) Catalysts in E-Selective Alkyne Semihydrogenation: A Mechanistic Investigation. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 35695788 DOI: 10.1002/chem.202201766  0.242
2022 Paul S, Morgante P, MacMillan SN, Autschbach J, Lacy D. Hydrogenative catalysis with three-coordinate zinc complexes supported with PN ligands is enhanced compared to PNP analogs. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 35522212 DOI: 10.1002/chem.202201042  0.243
2022 Rosala-Hallas A, Jones AP, Williamson PR, Bedson E, Compton V, Fernandes RM, Lacy D, Lyttle MD, Peak M, Thorburn K, Woolfall K, Van Miert C, McNamara PS. Which outcomes should be used in future bronchiolitis trials? Developing a bronchiolitis core outcome set using a systematic review, Delphi survey and a consensus workshop. Bmj Open. 12: e052943. PMID 35264343 DOI: 10.1136/bmjopen-2021-052943  0.185
2022 Peritore-Galve FC, Shupe JA, Cave RJ, Childress KO, Washington MK, Kuehne SA, Lacy DB. Glucosyltransferase-dependent and independent effects of Clostridioides difficile toxins during infection. Plos Pathogens. 18: e1010323. PMID 35176123 DOI: 10.1371/journal.ppat.1010323  0.8
2022 Varley CD, Rogers LM, Dixon BR, Bernard SC, Lacy DB, Sulpizio E, Aronoff DM, Townes JM. Persistent bacteremia and psoas abscess caused by a lethal toxin-deficient Paeniclostridiumsordellii. Anaerobe. 102520. PMID 35085782 DOI: 10.1016/j.anaerobe.2022.102520  0.27
2022 Allen D, Lloyd A, Edwards D, Hood K, Huang C, Hughes J, Jacob N, Lacy D, Moriarty Y, Oliver A, Preston J, Sefton G, Sinha I, Skone R, Strange H, et al. Development, implementation and evaluation of an evidence-based paediatric early warning system improvement programme: the PUMA mixed methods study. Bmc Health Services Research. 22: 9. PMID 34974841 DOI: 10.1186/s12913-021-07314-2  0.215
2021 Kordus SL, Thomas AK, Lacy DB. Clostridioides difficile toxins: mechanisms of action and antitoxin therapeutics. Nature Reviews. Microbiology. PMID 34837014 DOI: 10.1038/s41579-021-00660-2  0.355
2021 Caso GC, McClain MS, Erwin AL, Truelock MD, Campbell AM, Leasure CS, Nagel M, Schey KL, Lacy DB, Ohi MD, Cover TL. Functional properties of oligomeric and monomeric forms of VacA toxin. Infection and Immunity. IAI0034821. PMID 34543122 DOI: 10.1128/IAI.00348-21  0.375
2021 Sheedlo MJ, Durie CL, Chung JM, Chang L, Roberts J, Swanson M, Lacy DB, Ohi MD. Cryo-EM reveals new species-specific proteins and symmetry elements in the Legionella pneumophila Dot/Icm T4SS. Elife. 10. PMID 34519271 DOI: 10.7554/eLife.70427  0.765
2021 Wexler AG, Guiberson ER, Beavers WN, Shupe JA, Washington MK, Lacy DB, Caprioli RM, Spraggins JM, Skaar EP. Clostridioides difficile infection induces a rapid influx of bile acids into the gut during colonization of the host. Cell Reports. 36: 109683. PMID 34496241 DOI: 10.1016/j.celrep.2021.109683  0.543
2021 Monaghan TM, Seekatz AM, Markham NO, Yau TO, Hatziapostolou M, Jilani T, Christodoulou N, Roach B, Birli E, Pomenya O, Louie T, Lacy DB, Kim P, Lee C, Kao D, et al. Fecal microbiota transplantation for recurrent Clostridioides difficile infection associates with functional alterations in circulating microRNAs. Gastroenterology. PMID 33844988 DOI: 10.1053/j.gastro.2021.03.050  0.248
2021 Markham NO, Bloch SC, Shupe JA, Laubacher EN, Thomas AK, Kroh HK, Childress KO, Peritore-Galve FC, Washington MK, Coffey RJ, Lacy DB. Murine intrarectal instillation of purified recombinant toxins enables mechanistic studies of pathogenesis. Infection and Immunity. PMID 33468584 DOI: 10.1128/IAI.00543-20  0.793
2020 Rosala-Hallas A, Jones AP, Bedson E, Compton V, Fernandes RM, Lacy D, Lyttle MD, Peak M, Thorburn K, van Miert C, Woolfall K, McNamara PS. National survey of feasibility of NIV trials for management of children with bronchiolitis. Bmj Paediatrics Open. 4: e000780. PMID 33134562 DOI: 10.1136/bmjpo-2020-000780  0.201
2020 Janezic S, Dingle K, Alvin J, Accetto T, Didelot X, Crook DW, Lacy DB, Rupnik M. Comparative genomics of toxinotypes identifies module-based toxin gene evolution. Microbial Genomics. 6. PMID 33030421 DOI: 10.1099/mgen.0.000449  0.347
2020 Parnell JM, Fazili I, Bloch SC, Lacy DB, Garcia-Lopez VA, Bernard R, Skaar EP, Edwards KM, Nicholson MR. Two-Step Testing for Clostridioides Difficile is Inadequate in Differentiating Infection From Colonization in Children. Journal of Pediatric Gastroenterology and Nutrition. PMID 32925555 DOI: 10.1097/Mpg.0000000000002944  0.558
2020 Sheedlo MJ, Chung JM, Sawhney N, Durie CL, Cover TL, Ohi MD, Lacy DB. Cryo-EM reveals species-specific components within the Cag type IV secretion system core complex. Elife. 9. PMID 32876048 DOI: 10.7554/Elife.59495  0.762
2020 Durie CL, Sheedlo MJ, Chung JM, Byrne BG, Su M, Knight T, Swanson M, Lacy DB, Ohi MD. Structural analysis of the Dot/Icm Type IV Secretion System Core Complex. Elife. 9. PMID 32876045 DOI: 10.7554/Elife.59530  0.766
2020 Cover TL, Lacy DB, Ohi MD. The Helicobacter pylori Cag Type IV Secretion System. Trends in Microbiology. PMID 32451226 DOI: 10.1016/J.Tim.2020.02.004  0.425
2020 Mileto SJ, Jardé T, Childress KO, Jensen JL, Rogers AP, Kerr G, Hutton ML, Sheedlo MJ, Bloch SC, Shupe JA, Horvay K, Flores T, Engel R, Wilkins S, McMurrick PJ, ... Lacy DB, et al. infection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 32198200 DOI: 10.1073/Pnas.1915255117  0.763
2020 Jones MM, Chapman K, Lacy D, Cannon S, Schnetter V. ADN to BSN Transitioning: An Early Decision Model. Nursing Education Perspectives. PMID 32168089 DOI: 10.1097/01.NEP.0000000000000512  0.184
2020 Tam J, Icho S, Utama E, Orrell KE, Gómez-Biagi RF, Theriot CM, Kroh HK, Rutherford SA, Lacy DB, Melnyk RA. Intestinal bile acids directly modulate the structure and function of TcdB toxin. Proceedings of the National Academy of Sciences of the United States of America. PMID 32152097 DOI: 10.1073/Pnas.1916965117  0.679
2020 Sheedlo MJ, Anderson DM, Thomas AK, Lacy DB. Structural elucidation of the transferase toxin reveals a single-site binding mode for the enzyme. Proceedings of the National Academy of Sciences of the United States of America. PMID 32123082 DOI: 10.1073/Pnas.1920555117  0.785
2020 Farrow MA, Chumbler NM, Bloch SC, King M, Moton-Melancon K, Shupe J, Washington MK, Spiller BW, Lacy DB. A small molecule inhibitor screen reveals calcium channel signaling as a mechanistic mediator of Clostridium difficile TcdB-induced necrosis. Acs Chemical Biology. PMID 31909964 DOI: 10.1021/Acschembio.9B00906  0.679
2020 Chung JM, Sheedlo MJ, Campbell AM, Sawhney N, Frick-Cheng AE, Lacy DB, Cover TL, Ohi MD. Structure of the Helicobacter pylori Cag Type IV Secretion System Biophysical Journal. 118: 295a. DOI: 10.2210/Pdb6Oeg/Pdb  0.749
2019 Anderson DM, Sheedlo MJ, Jensen JL, Lacy DB. Structural insights into the transition of Clostridioides difficile binary toxin from prepore to pore. Nature Microbiology. PMID 31712627 DOI: 10.1038/S41564-019-0601-8  0.798
2019 Chung JM, Sheedlo MJ, Campbell AM, Sawhney N, Frick-Cheng AE, Lacy DB, Cover TL, Ohi MD. Structure of the Cag Type IV secretion system. Elife. 8. PMID 31210639 DOI: 10.7554/Elife.47644  0.767
2019 Yang S, Harding AT, Sweeney C, Miao D, Swan G, Zhou C, Jiang Z, Fitzgerald KA, Hammer G, Bergo MO, Kroh HK, Lacy DB, Sun C, Glogauer M, Que LG, et al. Control of antiviral innate immune response by protein geranylgeranylation. Science Advances. 5: eaav7999. PMID 31149635 DOI: 10.1126/Sciadv.Aav7999  0.401
2019 Trubey R, Huang C, Lugg-Widger FV, Hood K, Allen D, Edwards D, Lacy D, Lloyd A, Mann M, Mason B, Oliver A, Roland D, Sefton G, Skone R, Thomas-Jones E, et al. Validity and effectiveness of paediatric early warning systems and track and trigger tools for identifying and reducing clinical deterioration in hospitalised children: a systematic review. Bmj Open. 9: e022105. PMID 31061010 DOI: 10.1136/bmjopen-2018-022105  0.197
2019 Palmer LD, Jordan AT, Maloney KN, Farrow MA, Gutierrez DB, Gant-Branum R, Burns WJ, Romer CE, Tsui T, Allen JL, Beavers WN, Nei YW, Sherrod SD, Lacy DB, Norris JL, et al. Zinc intoxication induces ferroptosis in A549 human lung cells. Metallomics : Integrated Biometal Science. PMID 30968088 DOI: 10.1039/C8Mt00360B  0.558
2019 Su M, Erwin AL, Campbell AM, Pyburn TM, Salay LE, Hanks JL, Lacy DB, Akey DL, Cover TL, Ohi MD. Cryo-EM Analysis Reveals Structural Basis of Helicobacter pylori VacA Toxin Oligomerization. Journal of Molecular Biology. PMID 30954575 DOI: 10.1016/J.Jmb.2019.03.029  0.494
2019 Erwin AL, Su M, Campbell AM, Akey D, Lacy DB, Cover TL, Ohi MD. Structural Analysis of Helicobacter pylori VacA Reveals Insights into Oligomerization Microscopy and Microanalysis. 25: 1290-1291. DOI: 10.1017/S1431927619007189  0.421
2019 Nicholson MR, Parnell JM, Fazili I, Bloch SC, Lacy DB, Skaar EP, Edwards K. 238 – Nucleic Acid Amplification Followed by Enzyme Immunoassay Testing for Clostridium Difficile is Inadequate in Differentiating Infection Versus Colonization in Pediatric Patients Gastroenterology. 156: S-45-S-46. DOI: 10.1016/S0016-5085(19)36894-5  0.501
2018 van Miert C, Fernandes RM, Eccleson H, Bedson E, Lane S, Peak M, Thorburn K, Compton V, Woolfall K, Lacy D, Williamson P, McNamara PS. Non-invasive ventilation for the management of children with bronchiolitis (NOVEMBR): a feasibility study and core outcome set development protocol. Trials. 19: 627. PMID 30428935 DOI: 10.1186/s13063-018-2969-9  0.225
2018 Thomas-Jones E, Lloyd A, Roland D, Sefton G, Tume L, Hood K, Huang C, Edwards D, Oliver A, Skone R, Lacy D, Sinha I, Preston J, Mason B, Jacob N, et al. A prospective, mixed-methods, before and after study to identify the evidence base for the core components of an effective Paediatric Early Warning System and the development of an implementation package containing those core recommendations for use in the UK: Paediatric early warning system - utilisation and mortality avoidance- the PUMA study protocol. Bmc Pediatrics. 18: 244. PMID 30045717 DOI: 10.1186/s12887-018-1210-z  0.241
2018 Arkwright PD, MacMahon J, Koplin J, Rajput S, Cross S, Fitzsimons R, Davidson N, Deshpande V, Rao N, Lumsden C, Lacy D, Allen KJ, Vance G, Mwenechanya J, Fox AT, et al. Severity and threshold of peanut reactivity during hospital-based open oral food challenges: an international multi-center survey. Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology. PMID 30022517 DOI: 10.1111/pai.12959  0.198
2017 Kroh HK, Chandrasekaran R, Zhang Z, Rosenthal K, Woods R, Jin X, Nyborg AC, Rainey GJ, Warrener P, Melnyk RA, Spiller BW, Lacy DB. A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells. The Journal of Biological Chemistry. PMID 29180448 DOI: 10.1074/jbc.M117.813428  0.796
2017 Chandrasekaran R, Lacy DB. The role of toxins in Clostridium difficile infection. Fems Microbiology Reviews. PMID 29048477 DOI: 10.1093/femsre/fux048  0.35
2017 Gupta P, Zhang Z, Sugiman-Marangos SN, Tam J, Raman S, Julien JP, Kroh HK, Lacy DB, Murgolo N, Bekkari K, Therien AG, Hernandez LD, Melnyk RA. Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor binding determinants. The Journal of Biological Chemistry. PMID 28842504 DOI: 10.1074/Jbc.M117.806687  0.715
2017 Surdel MC, Horvath DJ, Lojek LJ, Fullen AR, Simpson J, Dutter BF, Salleng KJ, Ford JB, Jenkins JL, Nagarajan R, Teixeira PL, Albertolle M, Georgiev IS, Jansen ED, Sulikowski GA, ... Lacy DB, et al. Antibacterial photosensitization through activation of coproporphyrinogen oxidase. Proceedings of the National Academy of Sciences of the United States of America. PMID 28739897 DOI: 10.1073/Pnas.1700469114  0.577
2017 Kroh HK, Chandrasekaran R, Rosenthal K, Woods R, Jin X, Ohi MD, Nyborg AC, Rainey GJ, Warrener P, Spiller BW, Lacy DB. Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface. The Journal of Biological Chemistry. PMID 28705932 DOI: 10.1074/Jbc.M117.781112  0.742
2017 Young C, Conard PL, Armstrong ML, Lacy D. Older Military Veteran Care: Many Still Believe They Are Forgotten. Journal of Holistic Nursing : Official Journal of the American Holistic Nurses' Association. 898010117713582. PMID 28627285 DOI: 10.1177/0898010117713582  0.175
2017 Alvin JW, Lacy DB. Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue. Journal of Structural Biology. 198: 203-209. PMID 28433497 DOI: 10.1016/J.Jsb.2017.04.006  0.76
2017 Hernandez LD, Kroh HK, Hsieh E, Yang X, Beaumont M, Sheth PR, DiNunzio E, Rutherford SA, Ohi MD, Ermakov G, Xiao L, Secore S, Karczewski J, Racine F, Mayhood T, ... ... Lacy DB, et al. Epitopes and Mechanism of Action of the Clostridium Difficile Toxin A-Neutralizing Antibody Actoxumab. Journal of Molecular Biology. PMID 28232034 DOI: 10.1016/J.Jmb.2017.02.010  0.483
2017 Norris JL, Farrow MA, Gutierrez DB, Palmer LD, Muszynski N, Sherrod SD, Pino JC, Allen JL, Spraggins JM, Lubbock AL, Jordan AT, Burns W, Poland JC, Romer CE, Manier ML, ... ... Lacy DB, et al. An integrated, high-throughput, multi-omics platform enables data-driven construction of cellular responses and reveals global drug mechanisms of action. Journal of Proteome Research. PMID 28088864 DOI: 10.1021/Acs.Jproteome.6B01004  0.559
2017 Alvin JW, Lacy DB. Structure Function Studies of Large Clostridial Cytotoxins Toxinology. 1-18. DOI: 10.1007/978-94-007-6725-6_26-2  0.699
2016 Chandrasekaran R, Kenworthy AK, Lacy DB. Clostridium difficile Toxin A Undergoes Clathrin-Independent, PACSIN2-Dependent Endocytosis. Plos Pathogens. 12: e1006070. PMID 27942025 DOI: 10.1371/Journal.Ppat.1006070  0.48
2016 Chumbler NM, Rutherford SA, Zhang Z, Farrow MA, Lisher JP, Farquhar E, Giedroc DP, Spiller BW, Melnyk RA, Lacy DB. Crystal structure of Clostridium difficile toxin A. Nature Microbiology. 1: 15002. PMID 27571750 DOI: 10.1038/Nmicrobiol.2015.2  0.817
2016 Chumbler NM, Rutherford SA, Zhang Z, Farrow MA, Lisher JP, Farquhar E, Giedroc DP, Spiller BW, Melnyk RA, Lacy DB. Crystal structure of Clostridium difficile toxin A. Nature Microbiology. 1. PMID 27512603 DOI: 10.1038/nmicrobiol.2015.2  0.809
2016 Chumbler NM, Farrow MA, Lapierre LA, Franklin JL, Lacy DB. Clostridium difficile toxins TcdA and TcdB cause colonic tissue damage by distinct mechanisms. Infection and Immunity. PMID 27456833 DOI: 10.1128/Iai.00583-16  0.445
2016 González-Rivera C, Campbell AM, Rutherford SA, Pyburn TM, Foegeding NJ, Barke TL, Spiller BW, McClain MS, Ohi MD, Lacy DB, Cover TL. A non-oligomerizing mutant form of Helicobacter pylori VacA allows structural analysis of the p33 domain. Infection and Immunity. PMID 27382020 DOI: 10.1128/Iai.00254-16  0.739
2016 Craven R, Lacy DB. Clostridium sordellii Lethal-Toxin Autoprocessing and Membrane Localization Activities Drive GTPase Glucosylation Profiles in Endothelial Cells. Msphere. 1. PMID 27303685 DOI: 10.1128/mSphere.00012-15  0.426
2016 Smits WK, Lyras D, Lacy DB, Wilcox MH, Kuijper EJ. Clostridium difficile infection. Nature Reviews. Disease Primers. 2: 16020. PMID 27158839 DOI: 10.1038/nrdp.2016.20  0.336
2016 Reyes-Robles T, Lubkin A, Alonzo F, Lacy DB, Torres VJ. Exploiting dominant-negative toxins to combat Staphylococcus aureus pathogenesis. Embo Reports. 17: 780. PMID 27139260 DOI: 10.15252/embr.201670010  0.267
2016 Hawcutt DB, Jorgensen AL, Wallin N, Thompson B, Peak M, Lacy D, Newland P, Didi M, Couriel J, Blair J, Pirmohamed M, Smyth RL. Adrenal responses to a low-dose short synacthen test in children with asthma. Clinical Endocrinology. 84: 793. PMID 27043153 DOI: 10.1111/cen.13069  0.192
2016 Reyes-Robles T, Lubkin A, Alonzo F, Lacy DB, Torres VJ. Exploiting dominant-negative toxins to combat Staphylococcus aureus pathogenesis. Embo Reports. PMID 26882549 DOI: 10.15252/Embr.201540994  0.47
2016 Conard PL, Armstrong ML, Young C, Lacy D, Billings L. Person-centered older military veteran care when there are consequences. Nurse Education Today. PMID 26880332 DOI: 10.1016/j.nedt.2016.01.014  0.196
2016 Quesada-Gómez C, López-Ureña D, Chumbler N, Kroh HK, Castro-Peña C, Rodríguez C, Orozco-Aguilar J, González-Camacho S, Rucavado A, Guzmán-Verri C, Lawley TD, Lacy DB, Chaves-Olarte E. Analysis of TcdBs within the hypervirulent clade 2 reveals an impact of RhoA glucosylation in Clostridium difficile pro inflammatory activities. Infection and Immunity. PMID 26755157 DOI: 10.1128/Iai.01291-15  0.422
2016 Chandrasekaran R, Lacy DB. Visualizing the Entry of Clostridium difficile Toxin A into Human Colonic Epithelial Cells Microscopy and Microanalysis. 22: 1056-1057. DOI: 10.1017/S1431927616006127  0.378
2015 Wang X, Yamamoto Y, Wilson LH, Zhang T, Howitt BE, Farrow MA, Kern F, Ning G, Hong Y, Khor CC, Chevalier B, Bertrand D, Wu L, Nagarajan N, Sylvester FA, ... ... Lacy DB, et al. Cloning and variation of ground state intestinal stem cells. Nature. 522: 173-8. PMID 26040716 DOI: 10.1038/Nature14484  0.387
2015 LaFrance ME, Farrow MA, Chandrasekaran R, Sheng J, Rubin DH, Lacy DB. Identification of an epithelial cell receptor responsible for Clostridium difficile TcdB-induced cytotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 112: 7073-8. PMID 26038560 DOI: 10.1073/Pnas.1500791112  0.462
2015 Varela Chavez C, Hoos S, Haustant GM, Chenal A, England P, Blondel A, Pauillac S, Lacy DB, Popoff MR. The catalytic domains of Clostridium sordellii lethal toxin and related large clostridial glucosylating toxins specifically recognize the negatively charged phospholipids phosphatidylserine and phosphatidic acid. Cellular Microbiology. PMID 25882477 DOI: 10.1111/Cmi.12449  0.491
2015 Hawcutt DB, Jorgensen AL, Wallin N, Thompson B, Peak M, Lacy D, Newland P, Didi M, Couriel J, Blair J, Pirmohamed M, Smyth RL. Adrenal responses to a low-dose short synacthen test in children with asthma. Clinical Endocrinology. 82: 648-56. PMID 25378183 DOI: 10.1111/cen.12655  0.206
2014 Schnetter VA, Lacy D, Jones MM, Bakrim K, Allen PE, O'Neal C. Course development for web-based nursing education programs. Nurse Education in Practice. 14: 635-40. PMID 25154660 DOI: 10.1016/j.nepr.2014.06.007  0.2
2014 Zhang Z, Park M, Tam J, Auger A, Beilhartz GL, Lacy DB, Melnyk RA. Translocation domain mutations affecting cellular toxicity identify the Clostridium difficile toxin B pore. Proceedings of the National Academy of Sciences of the United States of America. 111: 3721-6. PMID 24567384 DOI: 10.1073/Pnas.1400680111  0.732
2014 DuMont AL, Yoong P, Liu X, Day CJ, Chumbler NM, James DB, Alonzo F, Bode NJ, Lacy DB, Jennings MP, Torres VJ. Identification of a crucial residue required for Staphylococcus aureus LukAB cytotoxicity and receptor recognition. Infection and Immunity. 82: 1268-76. PMID 24379286 DOI: 10.1128/Iai.01444-13  0.475
2014 Blair J, Lancaster G, Titman A, Peak M, Newlands P, Collingwood C, Chesters C, Moorcroft T, Wallin N, Hawcutt D, Gardner C, Didi M, Lacy D, Couriel J. Early morning salivary cortisol and cortisone, and adrenal responses to a simplified low-dose short Synacthen test in children with asthma. Clinical Endocrinology. 80: 376-83. PMID 23895277 DOI: 10.1111/cen.12302  0.193
2013 Farrow MA, Chumbler NM, Lapierre LA, Franklin JL, Rutherford SA, Goldenring JR, Lacy DB. Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex. Proceedings of the National Academy of Sciences of the United States of America. 110: 18674-9. PMID 24167244 DOI: 10.1073/Pnas.1313658110  0.428
2013 Reyes-Robles T, Alonzo F, Kozhaya L, Lacy DB, Unutmaz D, Torres VJ. Staphylococcus aureus leukotoxin ED targets the chemokine receptors CXCR1 and CXCR2 to kill leukocytes and promote infection. Cell Host & Microbe. 14: 453-9. PMID 24139401 DOI: 10.1016/J.Chom.2013.09.005  0.439
2013 Benefield DA, Dessain SK, Shine N, Ohi MD, Lacy DB. Molecular assembly of botulinum neurotoxin progenitor complexes. Proceedings of the National Academy of Sciences of the United States of America. 110: 5630-5. PMID 23509303 DOI: 10.1073/Pnas.1222139110  0.405
2013 Slater LH, Hett EC, Mark K, Chumbler NM, Patel D, Lacy DB, Collier RJ, Hung DT. Identification of novel host-targeted compounds that protect from anthrax lethal toxin-induced cell death. Acs Chemical Biology. 8: 812-22. PMID 23343607 DOI: 10.1021/Cb300555N  0.563
2013 Chambers MG, Pyburn TM, González-Rivera C, Collier SE, Eli I, Yip CK, Takizawa Y, Lacy DB, Cover TL, Ohi MD. Structural analysis of the oligomeric states of Helicobacter pylori VacA toxin. Journal of Molecular Biology. 425: 524-35. PMID 23178866 DOI: 10.1016/J.Jmb.2012.11.020  0.509
2013 Chambers MG, Pyburn T, González-Rivera C, Collier SE, Takizawa Y, Lacy DB, Cover TL, Ohi MD. Structural Characterization of the Helicobacter Pylori VacA Toxin by Single Particle Em and X-Ray Crystallography Biophysical Journal. 104: 21a. DOI: 10.1016/J.Bpj.2012.11.155  0.518
2012 Chumbler NM, Farrow MA, Lapierre LA, Franklin JL, Haslam DB, Haslam D, Goldenring JR, Lacy DB. Clostridium difficile Toxin B causes epithelial cell necrosis through an autoprocessing-independent mechanism. Plos Pathogens. 8: e1003072. PMID 23236283 DOI: 10.1371/Journal.Ppat.1003072  0.487
2012 Pruitt RN, Lacy DB. Toward a structural understanding of Clostridium difficile toxins A and B. Frontiers in Cellular and Infection Microbiology. 2: 28. PMID 22919620 DOI: 10.3389/Fcimb.2012.00028  0.446
2012 Pruitt RN, Chumbler NM, Rutherford SA, Farrow MA, Friedman DB, Spiller B, Lacy DB. Structural determinants of Clostridium difficile toxin A glucosyltransferase activity. The Journal of Biological Chemistry. 287: 8013-20. PMID 22267739 DOI: 10.1074/Jbc.M111.298414  0.731
2012 Chumbler NM, Farrow MA, Lapierre LA, Franklin JL, Haslam DB, Goldenring JR, Lacy DB. Correction: Clostridium difficile Toxin B Causes Epithelial Cell Necrosis through an Autoprocessing-Independent Mechanism Plos Pathogens. 8. DOI: 10.1371/annotation/f9017013-88c8-44db-818b-08b9322f3814  0.301
2011 Mushrush DJ, Koteiche HA, Sammons MA, Link AJ, McHaourab HS, Lacy DB. Studies of the mechanistic details of the pH-dependent association of botulinum neurotoxin with membranes. The Journal of Biological Chemistry. 286: 27011-8. PMID 21652698 DOI: 10.1074/Jbc.M111.256982  0.787
2011 Johnson PM, Chen SS, Santomango TS, Williams PE, Lacy DB, McGuinness OP. Continuous low-dose fructose infusion does not reverse glucagon-mediated decrease in hepatic glucose utilization. Metabolism: Clinical and Experimental. 60: 867-73. PMID 20940071 DOI: 10.1016/j.metabol.2010.08.006  0.229
2010 Gangwer KA, Shaffer CL, Suerbaum S, Lacy DB, Cover TL, Bordenstein SR. Molecular evolution of the Helicobacter pylori vacuolating toxin gene vacA. Journal of Bacteriology. 192: 6126-35. PMID 20870762 DOI: 10.1128/Jb.01081-10  0.773
2010 Pruitt RN, Chambers MG, Ng KK, Ohi MD, Lacy DB. Structural organization of the functional domains of Clostridium difficile toxins A and B. Proceedings of the National Academy of Sciences of the United States of America. 107: 13467-72. PMID 20624955 DOI: 10.1073/Pnas.1002199107  0.51
2010 González-Rivera C, Gangwer KA, McClain MS, Eli IM, Chambers MG, Ohi MD, Lacy DB, Cover TL. Reconstitution of Helicobacter pylori VacA toxin from purified components. Biochemistry. 49: 5743-52. PMID 20527875 DOI: 10.1021/Bi100618G  0.777
2010 Schmitt J, Karalewitz A, Benefield DA, Mushrush DJ, Pruitt RN, Spiller BW, Barbieri JT, Lacy DB. Structural analysis of botulinum neurotoxin type G receptor binding . Biochemistry. 49: 5200-5. PMID 20507178 DOI: 10.1021/Bi100412V  0.769
2010 Ivie SE, McClain MS, Algood HM, Lacy DB, Cover TL. Analysis of a beta-helical region in the p55 domain of Helicobacter pylori vacuolating toxin. Bmc Microbiology. 10: 60. PMID 20178613 DOI: 10.1186/1471-2180-10-60  0.479
2010 Collins HL, Almond SL, Thompson B, Lacy D, Greaney M, Baillie CT, Kenny SE. Comparison of childhood appendicitis management in the regional paediatric surgery unit and the district general hospital. Journal of Pediatric Surgery. 45: 300-2. PMID 20152340 DOI: 10.1016/j.jpedsurg.2009.10.079  0.189
2009 Pruitt RN, Chagot B, Cover M, Chazin WJ, Spiller B, Lacy DB. Structure-function analysis of inositol hexakisphosphate-induced autoprocessing in Clostridium difficile toxin A. The Journal of Biological Chemistry. 284: 21934-40. PMID 19553670 DOI: 10.1074/Jbc.M109.018929  0.741
2009 Chen SS, Santomango TS, Williams PE, Lacy DB, McGuinness OP. Glucagon-mediated impairments in hepatic and peripheral tissue nutrient disposal are not aggravated by increased lipid availability. American Journal of Physiology. Endocrinology and Metabolism. 296: E1172-8. PMID 19208853 DOI: 10.1152/ajpendo.90821.2008  0.24
2008 Fischer A, Mushrush DJ, Lacy DB, Montal M. Botulinum neurotoxin devoid of receptor binding domain translocates active protease. Plos Pathogens. 4: e1000245. PMID 19096517 DOI: 10.1371/Journal.Ppat.1000245  0.786
2008 Ivie SE, McClain MS, Torres VJ, Algood HM, Lacy DB, Yang R, Blanke SR, Cover TL. Helicobacter pylori VacA subdomain required for intracellular toxin activity and assembly of functional oligomeric complexes. Infection and Immunity. 76: 2843-51. PMID 18443094 DOI: 10.1128/Iai.01664-07  0.518
2008 Scobie HM, Wigelsworth DJ, Marlett JM, Thomas D, Rainey GJA, Lacy DB, Manchester M, Collier RJ, Young JAT. Correction: Anthrax Toxin Receptor 2–Dependent Lethal Toxin Killing In Vivo Plos Pathogens. 4. DOI: 10.1371/Annotation/08C1Bcf0-Da65-4Abd-97C7-5Df86B1120B5  0.502
2007 Gangwer KA, Mushrush DJ, Stauff DL, Spiller B, McClain MS, Cover TL, Lacy DB. Crystal structure of the Helicobacter pylori vacuolating toxin p55 domain. Proceedings of the National Academy of Sciences of the United States of America. 104: 16293-8. PMID 17911250 DOI: 10.1073/Pnas.0707447104  0.77
2007 Scobie HM, Marlett JM, Rainey GJ, Lacy DB, Collier RJ, Young JA. Anthrax toxin receptor 2 determinants that dictate the pH threshold of toxin pore formation. Plos One. 2: e329. PMID 17389920 DOI: 10.1371/Journal.Pone.0000329  0.571
2007 Chen SS, Zhang Y, Santomango TS, Williams PE, Lacy DB, McGuinness OP. Glucagon chronically impairs hepatic and muscle glucose disposal. American Journal of Physiology. Endocrinology and Metabolism. 292: E928-35. PMID 17132827 DOI: 10.1152/ajpendo.00063.2006  0.227
2007 Connolly CC, Papa T, Smith MS, Lacy DB, Williams PE, Moore MC. Hepatic and muscle insulin action during late pregnancy in the dog. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 292: R447-52. PMID 16973936 DOI: 10.1152/ajpregu.00385.2006  0.194
2006 Scobie HM, Wigelsworth DJ, Marlett JM, Thomas D, Rainey GJ, Lacy DB, Manchester M, Collier RJ, Young JA. Anthrax toxin receptor 2-dependent lethal toxin killing in vivo. Plos Pathogens. 2: e111. PMID 17054395 DOI: 10.1371/Journal.Ppat.0020111  0.577
2006 Canniff KM, Smith MS, Lacy DB, Williams PE, Moore MC. Glucagon secretion and autonomic signaling during hypoglycemia in late pregnancy. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 291: R788-95. PMID 16556905 DOI: 10.1152/ajpregu.00125.2006  0.197
2006 Melnyk RA, Hewitt KM, Lacy DB, Lin HC, Gessner CR, Li S, Woods VL, Collier RJ. Structural determinants for the binding of anthrax lethal factor to oligomeric protective antigen. The Journal of Biological Chemistry. 281: 1630-5. PMID 16293620 DOI: 10.1074/Jbc.M511164200  0.739
2005 Lacy DB, Lin HC, Melnyk RA, Schueler-Furman O, Reither L, Cunningham K, Baker D, Collier RJ. A model of anthrax toxin lethal factor bound to protective antigen. Proceedings of the National Academy of Sciences of the United States of America. 102: 16409-14. PMID 16251269 DOI: 10.1073/Pnas.0508259102  0.741
2005 Krantz BA, Melnyk RA, Zhang S, Juris SJ, Lacy DB, Wu Z, Finkelstein A, Collier RJ. A phenylalanine clamp catalyzes protein translocation through the anthrax toxin pore. Science (New York, N.Y.). 309: 777-81. PMID 16051798 DOI: 10.1126/Science.1113380  0.795
2005 Camacho RC, Lacy DB, James FD, Donahue EP, Wasserman DH. 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside renders glucose output by the liver of the dog insensitive to a pharmacological increment in insulin. American Journal of Physiology. Endocrinology and Metabolism. 289: E1039-43. PMID 16046457 DOI: 10.1152/ajpendo.00247.2005  0.225
2005 Chen SS, Torres-Sanchez CJ, Hosein N, Zhang Y, Lacy DB, Chang C, McGuinness OP. Route-dependent effect of nutritional support on liver glucose uptake. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 289: R1319-27. PMID 15994371 DOI: 10.1152/ajpregu.00175.2005  0.238
2005 Batista MR, Smith MS, Snead WL, Connolly CC, Lacy DB, Moore MC. Chronic estradiol and progesterone treatment in conscious dogs: effects on insulin sensitivity and response to hypoglycemia. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 289: R1064-73. PMID 15961530 DOI: 10.1152/ajpregu.00311.2005  0.206
2005 Grubert JM, Lautz M, Lacy DB, Moore MC, Farmer B, Penaloza A, Cherrington AD, McGuinness OP. Impact of continuous and pulsatile insulin delivery on net hepatic glucose uptake. American Journal of Physiology. Endocrinology and Metabolism. 289: E232-40. PMID 15755768 DOI: 10.1152/ajpendo.00567.2004  0.219
2005 Camacho RC, Pencek RR, Lacy DB, James FD, Donahue EP, Wasserman DH. Portal venous 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion overcomes hyperinsulinemic suppression of endogenous glucose output. Diabetes. 54: 373-82. PMID 15677495 DOI: 10.2337/diabetes.54.2.373  0.244
2005 Pencek RR, Shearer J, Camacho RC, James FD, Lacy DB, Fueger PT, Donahue EP, Snead W, Wasserman DH. 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside causes acute hepatic insulin resistance in vivo. Diabetes. 54: 355-60. PMID 15677492 DOI: 10.2337/Diabetes.54.2.355  0.216
2005 Chen SS, Torres-Sanchez CJ, Hosein N, Zhang Y, Lacy DB, McGuinness OP. Time course of the hepatic adaptation to TPN: interaction with glycogen depletion. American Journal of Physiology. Endocrinology and Metabolism. 288: E163-70. PMID 15339746 DOI: 10.1152/ajpendo.00192.2004  0.241
2004 Pencek RR, James FD, Lacy DB, Jabbour K, Williams PE, Fueger PT, Wasserman DH. Exercise-induced changes in insulin and glucagon are not required for enhanced hepatic glucose uptake after exercise but influence the fate of glucose within the liver. Diabetes. 53: 3041-7. PMID 15561932 DOI: 10.2337/Diabetes.53.12.3041  0.218
2004 Pencek RR, Battram D, Shearer J, James FD, Lacy DB, Jabbour K, Williams PE, Graham TE, Wasserman DH. Portal vein caffeine infusion enhances net hepatic glucose uptake during a glucose load in conscious dogs. The Journal of Nutrition. 134: 3042-6. PMID 15514273 DOI: 10.1093/JN/134.11.3042  0.22
2004 Camacho RC, Denny JC, Pencek RR, Koyama Y, Lacy DB, James FD, Wasserman DH. Portal venous hyperinsulinemia does not stimulate gut glucose absorption in the conscious dog. Metabolism: Clinical and Experimental. 53: 1290-5. PMID 15375784 DOI: 10.1016/J.Metabol.2004.07.002  0.232
2004 Lacy DB, Wigelsworth DJ, Melnyk RA, Harrison SC, Collier RJ. Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation. Proceedings of the National Academy of Sciences of the United States of America. 101: 13147-51. PMID 15326297 DOI: 10.1073/Pnas.0405405101  0.719
2004 Connolly CC, Aglione LN, Smith MS, Lacy DB, Moore MC. Pregnancy impairs the counterregulatory response to insulin-induced hypoglycemia in the dog. American Journal of Physiology. Endocrinology and Metabolism. 287: E480-8. PMID 15126242 DOI: 10.1152/ajpendo.00529.2003  0.208
2004 Lacy DB, Wigelsworth DJ, Scobie HM, Young JA, Collier RJ. Crystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor. Proceedings of the National Academy of Sciences of the United States of America. 101: 6367-72. PMID 15079089 DOI: 10.1073/Pnas.0401506101  0.584
2004 Camacho RC, Lacy DB, James FD, Coker RH, Wasserman DH. Hepatic glucose autoregulation: responses to small, non-insulin-induced changes in arterial glucose. American Journal of Physiology. Endocrinology and Metabolism. 287: E269-74. PMID 15053988 DOI: 10.1152/ajpendo.00040.2004  0.225
2004 Wigelsworth DJ, Krantz BA, Christensen KA, Lacy DB, Juris SJ, Collier RJ. Binding stoichiometry and kinetics of the interaction of a human anthrax toxin receptor, CMG2, with protective antigen. The Journal of Biological Chemistry. 279: 23349-56. PMID 15044490 DOI: 10.1074/Jbc.M401292200  0.733
2004 Connolly CC, Aglione LN, Smith MS, Lacy DB, Moore MC. Insulin action during late pregnancy in the conscious dog. American Journal of Physiology. Endocrinology and Metabolism. 286: E909-15. PMID 14749203 DOI: 10.1152/ajpendo.00143.2003  0.198
2004 Camacho RC, Pencek RR, Lacy DB, James FD, Wasserman DH. Suppression of endogenous glucose production by mild hyperinsulinemia during exercise is determined predominantly by portal venous insulin. Diabetes. 53: 285-93. PMID 14747277 DOI: 10.2337/diabetes.53.2.285  0.216
2004 Chen SS, Donmoyer CM, Pearson DA, Poole A, Zhang Y, Lacy DB, McGuinness OP. Impact of infection on glucose-dependent liver glucose uptake during TPN: interaction with insulin. American Journal of Physiology. Endocrinology and Metabolism. 286: E286-95. PMID 14532169 DOI: 10.1152/Ajpendo.00286.2003  0.267
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2002 Donmoyer CM, Lacy DB, Zhang Y, Chen SS, McGuinness OP. Impact of chronic fructose infusion on hepatic metabolism during TPN administration. American Journal of Physiology. Endocrinology and Metabolism. 283: E1151-8. PMID 12424103 DOI: 10.1152/Ajpendo.00223.2001  0.261
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2002 Chen SS, Donmoyer CM, Ejiofor J, McCay J, Archuletta R, Lacy DB, McGuinness OP. Impact of intraportal N(omega)-nitro-L-arginine infusion on hepatic glucose metabolism in total parenteral nutrition-adapted dogs: interaction with infection. Metabolism: Clinical and Experimental. 51: 274-83. PMID 11887160 DOI: 10.1053/Meta.2002.30501  0.244
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2001 Donmoyer CM, Ejiofor J, Lacy DB, Chen SS, McGuinness OP. Fructose augments infection-impaired net hepatic glucose uptake during TPN administration. American Journal of Physiology. Endocrinology and Metabolism. 280: E703-11. PMID 11287352 DOI: 10.1152/Ajpendo.2001.280.5.E703  0.267
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1998 LACY D. Light and electron microscopy and its use in the study of factors influencing spermatogenesis in the rat. Journal. Royal Microscopical Society (Great Britain). 79: 209-25. PMID 13758142 DOI: 10.1111/j.1365-2818.1959.tb04469.x  0.204
1998 LACY D, ROTBLAT J. Study of normal and irradiated boundary tissue of the seminiferous tubules of the rat. Experimental Cell Research. 21: 49-70. PMID 13758141 DOI: 10.1016/0014-4827(60)90346-3  0.196
1998 Lacy DB, Stevens RC. Unraveling the structures and modes of action of bacterial toxins. Current Opinion in Structural Biology. 8: 778-84. PMID 9914258 DOI: 10.1016/S0959-440X(98)80098-5  0.604
1998 Locksley RM, Fowell DJ, Shinkai K, Wakil AE, Lacy D, Bix M. Development of CD4+ effector T cells and susceptibility to infectious diseases. Advances in Experimental Medicine and Biology. 452: 45-52. PMID 9889958 DOI: 10.1007/978-1-4615-5355-7_6  0.273
1998 Lang CH, Frost RA, Ejiofor J, Lacy DB, McGuinness OP. Hepatic production and intestinal uptake of IGF-I: response to infection. The American Journal of Physiology. 275: G1291-8. PMID 9843765  0.276
1998 Fowell DJ, Bix M, Shinkai K, Lacy D, Locksley RM. Disease susceptibility and development of the cytokine repertoire in the murine Leishmania major model. European Cytokine Network. 9: 102-6. PMID 9831197  0.267
1998 McGuinness OP, Donmoyer C, Ejiofor J, McElligott S, Lacy DB. Hepatic and muscle glucose metabolism during total parenteral nutrition: impact of infection. The American Journal of Physiology. 275: E763-9. PMID 9814994 DOI: 10.1152/Ajpendo.1998.275.5.E763  0.235
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1997 Lacy DB, Stevens RC. Recombinant expression and purification of the botulinum neurotoxin type A translocation domain. Protein Expression and Purification. 11: 195-200. PMID 9367816 DOI: 10.1006/Prep.1997.0772  0.597
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1997 Zinker BA, Allison RG, Lacy DB, Wasserman DH. Interaction of exercise, insulin, and hypoglycemia studied using euglycemic and hypoglycemic insulin clamps. The American Journal of Physiology. 272: E530-42. PMID 9142871 DOI: 10.1152/AJPENDO.1997.272.4.E530  0.208
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