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Bruce D. Hammock - Publications

Affiliations: 
1975-1980 University of California, Riverside, Riverside, CA, United States 
 1980- Entomology University of California, Davis, Davis, CA 
Area:
Pesticide Biotechnology
Website:
http://www.biopestlab.ucdavis.edu/Our_People/Professor_Bruce_D_Hammock/
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Year Citation  Score
2023 Wang W, Wang Y, Wagner KM, Lee RD, Hwang SH, Morisseau C, Wulff H, Hammock BD. Aflatoxin B Increases Soluble Epoxide Hydrolase in the Brain and Induces Neuroinflammation and Dopaminergic Neurotoxicity. International Journal of Molecular Sciences. 24. PMID 37373086 DOI: 10.3390/ijms24129938  0.527
2023 Wang W, Wagner KM, Wang Y, Singh N, Yang J, He Q, Morisseau C, Hammock BD. Soluble Epoxide Hydrolase Contributes to Cell Senescence and ER Stress in Aging Mice Colon. International Journal of Molecular Sciences. 24. PMID 36901999 DOI: 10.3390/ijms24054570  0.544
2023 Takeshita AA, Hammock BD, Wagner KM. Soluble epoxide hydrolase inhibition alleviates chemotherapy induced neuropathic pain. Frontiers in Pain Research (Lausanne, Switzerland). 3: 1100524. PMID 36700145 DOI: 10.3389/fpain.2022.1100524  0.543
2023 Atone J, Wagner K, Koike S, Yang J, Hwang SH, Hammock BD. Inhibition of Soluble Epoxide Hydrolase Reduces Paraquat Neurotoxicity in Rodents. Environmental Toxicology and Pharmacology. 104070. PMID 36682504 DOI: 10.1016/j.etap.2023.104070  0.554
2022 Nguyen PT, Nguyen HM, Wagner KM, Stewart R, Singh V, Thapa P, Chen YJ, Lillya MW, Ton AT, Kondo R, Ghetti A, Pennington MW, Hammock B, Griffith TN, Sack JT, et al. Computational design of peptides to target Na1.7 channel with high potency and selectivity for the treatment of pain. Elife. 11. PMID 36576241 DOI: 10.7554/eLife.81727  0.534
2022 Wang W, Wang Y, Yang J, Wagner KM, Hwang SH, Cheng J, Singh N, Edwards P, Morisseau C, Zhang G, Panigrahy D, Hammock BD. Aflatoxin B exposure disrupts the intestinal immune function via a soluble epoxide hydrolase-mediated manner. Ecotoxicology and Environmental Safety. 249: 114417. PMID 36525946 DOI: 10.1016/j.ecoenv.2022.114417  0.558
2022 Matsumoto N, Singh N, Lee KS, Barnych B, Morisseau C, Hammock BD. The epoxy fatty acid pathway enhances cAMP in mammalian cells through multiple mechanisms. Prostaglandins & Other Lipid Mediators. 162: 106662. PMID 35779854 DOI: 10.1016/j.prostaglandins.2022.106662  0.504
2022 Zhang C, Li W, Li X, Wan D, Mack S, Zhang J, Wagner K, Wang C, Tan B, Chen J, Wu CW, Tsuji K, Takeuchi M, Chen Z, Hammock BD, et al. Novel aerosol treatment of airway hyper-reactivity and inflammation in a murine model of asthma with a soluble epoxide hydrolase inhibitor. Plos One. 17: e0266608. PMID 35443010 DOI: 10.1371/journal.pone.0266608  0.552
2021 Ulu A, Velazquez JV, Burr A, Sveiven SN, Yang J, Bravo C, Hammock BD, Nordgren TM. Sex-Specific Differences in Resolution of Airway Inflammation in Transgenic Mice Following Repetitive Agricultural Dust Exposure. Frontiers in Pharmacology. 12: 785193. PMID 35095496 DOI: 10.3389/fphar.2021.785193  0.598
2021 Wagner KM, Yang J, Morisseau C, Hammock BD. Soluble Epoxide Hydrolase Deletion Limits High-Fat Diet-Induced Inflammation. Frontiers in Pharmacology. 12: 778470. PMID 34975481 DOI: 10.3389/fphar.2021.778470  0.568
2021 McReynolds CB, Yang J, Guedes A, Morisseau C, Garcia R, Knych H, Tearney C, Hamamoto B, Hwang SH, Wagner K, Hammock BD. Species Differences in Metabolism of Soluble Epoxide Hydrolase Inhibitor, EC1728, Highlight the Importance of Clinically Relevant Screening Mechanisms in Drug Development. Molecules (Basel, Switzerland). 26. PMID 34443621 DOI: 10.3390/molecules26165034  0.563
2021 Singh N, Barnych B, Wagner KM, Wan D, Morisseau C, Hammock BD. Adrenic Acid-Derived Epoxy Fatty Acids Are Naturally Occurring Lipids and Their Methyl Ester Prodrug Reduces Endoplasmic Reticulum Stress and Inflammatory Pain. Acs Omega. 6: 7165-7174. PMID 33748630 DOI: 10.1021/acsomega.1c00241  0.599
2021 Hammock BD, McReynolds CB, Wagner K, Buckpitt A, Cortes-Puch I, Croston G, Lee KSS, Yang J, Schmidt WK, Hwang SH. Movement to the Clinic of Soluble Epoxide Hydrolase Inhibitor EC5026 as an Analgesic for Neuropathic Pain and for Use as a Nonaddictive Opioid Alternative. Journal of Medicinal Chemistry. PMID 33550801 DOI: 10.1021/acs.jmedchem.0c01886  0.594
2021 Wang Y, Wagner KM, Morisseau C, Hammock BD. Inhibition of the Soluble Epoxide Hydrolase as an Analgesic Strategy: A Review of Preclinical Evidence. Journal of Pain Research. 14: 61-72. PMID 33488116 DOI: 10.2147/JPR.S241893  0.584
2020 Singh N, Barnych B, Morisseau C, Wagner KM, Wan D, Takeshita A, Pham H, Xu T, Dandekar A, Liu JY, Hammock BD. -Benzyl-linoleamide, a Constituent of (Maca), Is an Orally Bioavailable Soluble Epoxide Hydrolase Inhibitor That Alleviates Inflammatory Pain. Journal of Natural Products. PMID 33320645 DOI: 10.1021/acs.jnatprod.0c00938  0.597
2020 Lee KSS, Ng JC, Yang J, Hwang SH, Morisseau C, Wagner K, Hammock BD. Preparation and evaluation of soluble epoxide hydrolase inhibitors with improved physical properties and potencies for treating diabetic neuropathic pain. Bioorganic & Medicinal Chemistry. 28: 115735. PMID 33007552 DOI: 10.1016/J.Bmc.2020.115735  0.634
2020 Shihadih DS, Harris TR, Kodani SD, Hwang SH, Lee KSS, Mavangira V, Hamamoto B, Guedes A, Hammock BD, Morisseau C. Selection of Potent Inhibitors of Soluble Epoxide Hydrolase for Usage in Veterinary Medicine. Frontiers in Veterinary Science. 7: 580. PMID 33005645 DOI: 10.3389/Fvets.2020.00580  0.391
2020 McReynolds C, Morisseau C, Wagner K, Hammock B. Epoxy Fatty Acids Are Promising Targets for Treatment of Pain, Cardiovascular Disease and Other Indications Characterized by Mitochondrial Dysfunction, Endoplasmic Stress and Inflammation. Advances in Experimental Medicine and Biology. 1274: 71-99. PMID 32894508 DOI: 10.1007/978-3-030-50621-6_5  0.636
2020 Wilt S, Kodani S, Le TNH, Nguyen L, Vo N, Ly T, Rodriguez M, Hudson PK, Morisseau C, Hammock BD, Pecic S. Development of multitarget inhibitors for the treatment of pain: Design, synthesis, biological evaluation and molecular modeling studies. Bioorganic Chemistry. 103: 104165. PMID 32891856 DOI: 10.1016/J.Bioorg.2020.104165  0.39
2020 Fishbein A, Hammock BD, Serhan CN, Panigrahy D. Carcinogenesis: Failure of resolution of inflammation? Pharmacology & Therapeutics. 107670. PMID 32891711 DOI: 10.1016/J.Pharmthera.2020.107670  0.305
2020 Wagner KM, Gomes A, McReynolds CB, Hammock BD. Soluble Epoxide Hydrolase Regulation of Lipid Mediators Limits Pain. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 32875445 DOI: 10.1007/S13311-020-00916-4  0.625
2020 Hildreth K, Kodani SD, Hammock BD, Zhao L. Cytochrome P450-derived linoleic acid metabolites EpOMEs and DiHOMEs: A review of recent studies. The Journal of Nutritional Biochemistry. 108484. PMID 32827665 DOI: 10.1016/J.Jnutbio.2020.108484  0.349
2020 Codony S, Pujol E, Pizarro-Delgado J, Feixas F, Valverde E, Loza MI, Brea JM, Sáez E, Oyarzabal J, Pineda-Lucena A, Pérez B, Perez C, Rodríguez-Franco MI, Leiva R, Osuna S, ... ... Hammock BD, et al. 2-Oxaadamant-1-yl ureas as soluble epoxide hydrolase inhibitors: evaluation in a murine model of acute pancreatitis. Journal of Medicinal Chemistry. PMID 32787085 DOI: 10.1021/Acs.Jmedchem.0C00310  0.33
2020 Li D, Cui Y, Morisseau C, Wagner KM, Cho YS, Hammock BD. Development of Highly Sensitive ELISA for Mouse Soluble Epoxide Hydrolase Detection by Combining a Polyclonal Capture Antibody with a Nanobody Tracer. Analytical Chemistry. PMID 32786492 DOI: 10.1021/Acs.Analchem.0C01511  0.603
2020 Burmistrov V, Morisseau C, Karlov D, Pitushkin D, Vernigora A, Rasskazova E, Butov GM, Hammock BD. Bioisosteric substitution of adamantane with bicyclic lipophilic groups improves water solubility of human soluble epoxide hydrolase inhibitors. Bioorganic & Medicinal Chemistry Letters. 30: 127430. PMID 32736212 DOI: 10.1016/J.Bmcl.2020.127430  0.316
2020 Teixeira JM, Abdalla HB, Basting RT, Hammock BD, Napimoga MH, Clemente-Napimoga JT. Peripheral soluble epoxide hydrolase inhibition reduces hypernociception and inflammation in albumin-induced arthritis in temporomandibular joint of rats. International Immunopharmacology. 87: 106841. PMID 32736189 DOI: 10.1016/J.Intimp.2020.106841  0.334
2020 Wang F, Li Z, Yang YY, Wan D, Vasylieva N, Zhang YQ, Cai J, Wang H, Shen YD, Xu ZL, Hammock BD. Chemiluminescent Enzyme Immunoassay and Bioluminescent Enzyme Immunoassay for Tenuazonic Acid Mycotoxin by Exploitation of Nanobody and Nanobody-Nanoluciferase Fusion. Analytical Chemistry. PMID 32702970 DOI: 10.1021/Acs.Analchem.0C02338  0.345
2020 Hammock BD, Wang W, Gilligan MM, Panigrahy D. Eicosanoids: the Overlooked Storm in COVID-19? The American Journal of Pathology. PMID 32650004 DOI: 10.1016/J.Ajpath.2020.06.010  0.348
2020 Trindade-da-Silva CA, Clemente-Napimoga JT, Abdalla HB, Rosa SM, Ueira-Vieira C, Morisseau C, Verri WA, Montalli VAM, Hammock BD, Napimoga MH. Soluble epoxide hydrolase inhibitor, TPPU, increases regulatory T cells pathway in an arthritis model. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32400048 DOI: 10.1096/Fj.202000415R  0.333
2020 Huerta-Yepez S, Tirado-Rodriguez A, Montecillo-Aguado MR, Yang J, Hammock BD, Hankinson O. Aryl Hydrocarbon Receptor-Dependent inductions of omega-3 and omega-6 polyunsaturated fatty acid metabolism act inversely on tumor progression. Scientific Reports. 10: 7843. PMID 32398692 DOI: 10.1038/S41598-020-64146-6  0.313
2020 Yang HH, Duan JX, Liu SK, Xiong JB, Guan XX, Zhong WJ, Sun CC, Zhang CY, Luo XQ, Zhang YF, Chen P, Hammock BD, Hwang SH, Jiang JX, Zhou Y, et al. A COX-2/sEH dual inhibitor PTUPB alleviates lipopolysaccharide-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation. Theranostics. 10: 4749-4761. PMID 32308747 DOI: 10.7150/Thno.43108  0.316
2020 Pressly B, Vasylieva N, Barnych B, Singh V, Singh L, Bruun DA, Hwang SH, Chen YJ, Fettinger JC, Johnnides S, Lein PJ, Yang J, Hammock BD, Wulff H. Comparison of the toxicokinetics of the convulsants picrotoxinin and tetramethylenedisulfotetramine (TETS) in mice. Archives of Toxicology. PMID 32239239 DOI: 10.1007/S00204-020-02728-Z  0.316
2020 Barnych B, Singh N, Negrel S, Zhang Y, Magis D, Roux C, Hua X, Ding Z, Morisseau C, Tantillo DJ, Siegel JB, Hammock BD. Development of potent inhibitors of the human microsomal epoxide hydrolase. European Journal of Medicinal Chemistry. 193: 112206. PMID 32203787 DOI: 10.1096/Fasebj.2020.34.S1.03639  0.368
2020 Zhang YF, Sun CC, Duan JX, Yang HH, Zhang CY, Xiong JB, Zhong WJ, Zu C, Guan XX, Jiang HL, Hammock BD, Hwang SH, Zhou Y, Guan CX. A COX-2/sEH dual inhibitor PTUPB ameliorates cecal ligation and puncture-induced sepsis in mice via anti-inflammation and anti-oxidative stress. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 126: 109907. PMID 32114358 DOI: 10.1016/J.Biopha.2020.109907  0.322
2020 Sun CP, Zhang J, Zhao WY, Yi J, Yan JK, Wang YL, Morisseau C, Liu ZB, Hammock BD, Ma XC. Protostane-type triterpenoids as natural soluble epoxide hydrolase inhibitors: Inhibition potentials and molecular dynamics. Bioorganic Chemistry. 96: 103637. PMID 32032849 DOI: 10.1016/J.Bioorg.2020.103637  0.32
2020 Sun CC, Zhang CY, Duan JX, Guan XX, Yang HH, Jiang HL, Hammock BD, Hwang SH, Zhou Y, Guan CX, Liu SK, Zhang J. PTUPB ameliorates high-fat diet-induced non-alcoholic fatty liver disease via inhibiting NLRP3 inflammasome activation in mice. Biochemical and Biophysical Research Communications. PMID 31973813 DOI: 10.1016/J.Bbrc.2019.12.131  0.319
2020 Burmistrov V, Morisseau C, D'yachenko V, Karlov D, Butov GM, Hammock BD. Imidazolidine-2,4,5- and pirimidine-2,4,6-triones - New primary pharmacophore for soluble epoxide hydrolase inhibitors with enhanced water solubility. Bioorganic & Medicinal Chemistry Letters. 30: 126908. PMID 31870649 DOI: 10.1016/J.Bmcl.2019.126908  0.304
2020 YANG J, Wagner K, Wan D, Hwang S, McReynolds CB, Hammock BD. Pharmacokinetics of a potent soluble epoxide hydrolase inhibitor in three formulations The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.09963  0.612
2019 Wagner KM, Atone J, Hammock BD. Soluble epoxide hydrolase inhibitor mediated analgesia lacks tolerance in rat models. Brain Research. 1728: 146573. PMID 31790682 DOI: 10.1016/J.Brainres.2019.146573  0.615
2019 He J, Ma S, Wu S, Xu J, Tian J, Li J, Gee SJ, Hammock BD, Li QX, Xu T. Construction of Immunomagnetic Particles with High Stability in Stringent Conditions by Site-Directed Immobilization of Multivalent Nanobodies onto Bacterial Magnetic Particles for the Rapid Environmental Detection of Tetrabromobisphenol-A. Analytical Chemistry. PMID 31763820 DOI: 10.1021/Acs.Analchem.9B04177  0.355
2019 Atone J, Wagner K, Hashimoto K, Hammock B. Prostaglandins and Other Lipid Mediators Cytochrome P450 derived epoxidized fatty acids as a therapeutic tool against neuroinflammatory diseases. Prostaglandins & Other Lipid Mediators. 106385. PMID 31698143 DOI: 10.1016/J.Prostaglandins.2019.106385  0.617
2019 Otoki Y, Metherel AH, Pedersen T, Yang J, Hammock BD, Bazinet RP, Newman JW, Taha AY. Acute Hypercapnia/Ischemia Alters the Esterification of Arachidonic Acid and Docosahexaenoic Acid Epoxide Metabolites in Rat Brain Neutral Lipids. Lipids. PMID 31691988 DOI: 10.1002/Lipd.12197  0.548
2019 Zhang CY, Duan JX, Yang HH, Sun CC, Zhong WJ, Tao JH, Guan XX, Jiang HL, Hammock BD, Hwang SH, Zhou Y, Guan CX. COX-2/sEH dual inhibitor PTUPB alleviates bleomycin-induced pulmonary fibrosis in mice via inhibiting senescence. The Febs Journal. PMID 31646730 DOI: 10.1111/Febs.15105  0.333
2019 Rand AA, Rajamani A, Kodani SD, Harris TR, Schlatt L, Barnych B, Passerini AG, Hammock BD. Epoxyeicosatrienoic acid (EET)-stimulated angiogenesis is mediated by epoxy hydroxyeicosatrienoic acids (EHETs) formed from COX-2. Journal of Lipid Research. PMID 31641036 DOI: 10.1194/Jlr.M094219  0.33
2019 Dileepan M, Rastle-Simpson S, Greenberg Y, Wijesinghe DS, Kumar NG, Yang J, Hwang SH, Hammock BD, Sriramarao P, Rao SP. Effect Of Dual sEH/COX-2 Inhibition on Allergen-Induced Airway Inflammation. Frontiers in Pharmacology. 10: 1118. PMID 31611798 DOI: 10.3389/Fphar.2019.01118  0.338
2019 Lee KSS, Yang J, Niu J, Ng CJ, Wagner KM, Dong H, Kodani SD, Wan D, Morisseau C, Hammock BD. Drug-Target Residence Time Affects Target Occupancy through Multiple Pathways. Acs Central Science. 5: 1614-1624. PMID 31572788 DOI: 10.1021/Acscentsci.9B00770  0.562
2019 Yang J, Bruun DA, Wang C, Wan D, Reynolds CB, Phu K, Inceoglu B, Lein PJ, Hammock BD. Lipidomes of brain from rats acutely intoxicated with diisopropylfluorophosphate identifies potential therapeutic targets. Toxicology and Applied Pharmacology. 114749. PMID 31521729 DOI: 10.1016/J.Taap.2019.114749  0.31
2019 Codony S, Valverde E, Leiva R, Brea J, Isabel Loza M, Morisseau C, Hammock BD, Vázquez S. Exploring the size of the lipophilic unit of the soluble epoxide hydrolase inhibitors. Bioorganic & Medicinal Chemistry. 115078. PMID 31488357 DOI: 10.1016/J.Bmc.2019.115078  0.341
2019 Kramer JS, Woltersdorf S, Duflot T, Hiesinger K, Lillich FF, Knöll F, Wittmann SK, Klingler FM, Brunst S, Chaikuad A, Morisseau C, Hammock BD, Buccellati C, Sala A, Rovati GE, et al. Discovery of first in vivo active inhibitors of soluble epoxide hydrolase (sEH) phosphatase domain. Journal of Medicinal Chemistry. PMID 31436984 DOI: 10.1021/Acs.Jmedchem.9B00445  0.321
2019 Liang Z, Zhang B, Xu M, Morisseau C, Hwang SH, Hammock BD, Li QX. TPPU, a Selective and Potent Dual Inhibitor of Soluble Epoxide Hydrolase and p38 Kinase Intervenes in Alzheimer's Signaling in Human Nerve Cells. Acs Chemical Neuroscience. PMID 31378059 DOI: 10.1021/Acschemneuro.9B00271  0.354
2019 Xia R, Sun L, Liao J, Li H, You X, Xu D, Yang J, Hwang SH, Jones RD, Hammock B, Yang GY. Inhibition of Pancreatic Carcinoma Growth Through Enhancing ω-3 Epoxy Polyunsaturated Fatty Acid Profile by Inhibition of Soluble Epoxide Hydrolase. Anticancer Research. 39: 3651-3660. PMID 31262891 DOI: 10.21873/Anticanres.13513  0.383
2019 Hiesinger K, Kramer JS, Achenbach J, Moser D, Weber J, Wittmann SK, Morisseau C, Angioni C, Geisslinger G, Kahnt AS, Kaiser A, Proschak A, Steinhilber D, Pogoryelov D, Wagner K, ... Hammock BD, et al. Computer-Aided Selective Optimization of Side Activities of Talinolol. Acs Medicinal Chemistry Letters. 10: 899-903. PMID 31223445 DOI: 10.2210/Pdb6Hgv/Pdb  0.608
2019 Klocke J, Ulu A, Wu K, Rudolph B, Dragun D, Gollasch M, Schunck WH, Hammock BD, Riemekasten G, Enghard P. Prophylactic inhibition of soluble epoxide hydrolase delays onset of nephritis and ameliorates kidney damage in NZB/W F1 mice. Scientific Reports. 9: 8993. PMID 31222024 DOI: 10.1038/S41598-019-45299-5  0.635
2019 McReynolds CB, Hwang SH, Yang J, Wan D, Wagner K, Morisseau C, Li D, Schmidt WK, Hammock BD. Pharmaceutical Effects of Inhibiting the Soluble Epoxide Hydrolase in Canine Osteoarthritis. Frontiers in Pharmacology. 10: 533. PMID 31214021 DOI: 10.3389/Fphar.2019.00533  0.643
2019 Deol P, Yang J, Morisseau C, Hammock BD, Sladek FM. Dimethyl Sulfoxide Decreases Levels of Oxylipin Diols in Mouse Liver. Frontiers in Pharmacology. 10: 580. PMID 31191316 DOI: 10.3389/Fphar.2019.00580  0.327
2019 Matsumoto N, Kataoka M, Hirosaki H, Morisseau C, Hammock BD, Suzuki E, Hasumi K. N-Substituted amino acid inhibitors of the phosphatase domain of the soluble epoxide hydrolase. Biochemical and Biophysical Research Communications. 515: 248-253. PMID 31146915 DOI: 10.1016/J.Bbrc.2019.05.088  0.323
2019 Wan D, Yang J, McReynolds CB, Barnych B, Wagner KM, Morisseau C, Hwang SH, Sun J, Blöcher R, Hammock BD. and Metabolism of a Potent Inhibitor of Soluble Epoxide Hydrolase, 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea. Frontiers in Pharmacology. 10: 464. PMID 31143115 DOI: 10.3389/Fphar.2019.00464  0.583
2019 Huo J, Barnych B, Li Z, Wan D, Li D, Vasylieva N, Knezevic S, Osipitan OA, Scott J, Zhang J, Hammock BD. Hapten Synthesis, Antibody Development, and a Highly Sensitive Indirect Competitive Chemiluminescent Enzyme Immunoassay for Detection of Dicamba. Journal of Agricultural and Food Chemistry. PMID 31042038 DOI: 10.1021/Acs.Jafc.8B07134  0.301
2019 Ren W, Li Z, Xu Y, Wan D, Barnych B, Li Y, Tu Z, He Q, Fu J, Hammock BD. One-step ultra-sensitive bioluminescent enzyme immunoassay based on nanobody/nano-luciferase fusion for detection of Aflatoxin B1 in cereal. Journal of Agricultural and Food Chemistry. PMID 30883117 DOI: 10.1021/Acs.Jafc.9B00688  0.301
2019 Zhu M, Wang L, Wu X, Na R, Wang Y, Li QX, Hammock BD. A novel and simple imidazo[1,2-a]pyridin fluorescent probe for the sensitive and selective imaging of cysteine in living cells and zebrafish. Analytica Chimica Acta. 1058: 155-165. PMID 30851849 DOI: 10.1016/J.Aca.2019.01.023  0.343
2019 Liu Z, Wang K, Wu S, Wang Z, Ding G, Hao X, Li QX, Li J, Gee SJ, Hammock BD, Xu T. Development of a camelid variable domain of heavy chain antibody-based immunoassay for the detection of carbaryl in cereals. Journal of the Science of Food and Agriculture. PMID 30851058 DOI: 10.1002/Jsfa.9672  0.311
2019 Vasylieva N, Kitamura S, Dong J, Barnych B, Hvorecny KL, Madden DR, Gee SJ, Wolan DW, Morisseau C, Hammock BD. Nanobody-based binding assay for the discovery of potent inhibitors of CFTR inhibitory factor (Cif). Analytica Chimica Acta. 1057: 106-113. PMID 30832908 DOI: 10.1016/J.Aca.2018.12.060  0.336
2019 He J, Tao X, Wang K, Ding G, Li J, Li QX, Gee SJ, Hammock BD, Xu T. One-step immunoassay for the insecticide carbaryl using a chicken single-chain variable fragment (scFv) fused to alkaline phosphatase. Analytical Biochemistry. PMID 30831096 DOI: 10.1016/J.Ab.2019.02.022  0.36
2019 Yao L, Cao B, Cheng Q, Cai W, Ye C, Liang J, Liu W, Tan L, Yan M, Li B, He J, Hwang SH, Zhang X, Wang C, Ai D, ... Hammock BD, et al. Inhibition of Soluble Epoxide Hydrolase Ameliorates Hyperhomocysteinemia-Induced Hepatic Steatosis by Enhancing β-oxidation of Fatty Acid in Mice. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 30789748 DOI: 10.1152/Ajpgi.00148.2018  0.352
2019 de Oliveira GS, Adriani PP, Ribeiro JA, Morisseau C, Hammock BD, Dias MVB, Chambergo FS. The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors. International Journal of Biological Macromolecules. PMID 30771398 DOI: 10.1016/J.Ijbiomac.2019.02.070  0.351
2019 Wang K, Liu Z, Ding G, Li J, Vasylieva N, Li QX, Li D, Gee SJ, Hammock BD, Xu T. Development of a one-step immunoassay for triazophos using camel single-domain antibody-alkaline phosphatase fusion protein. Analytical and Bioanalytical Chemistry. PMID 30706076 DOI: 10.1007/S00216-018-01563-7  0.382
2018 Hiesinger K, Wagner KM, Hammock BD, Proschak E, Hwang SH. Development of Multitarget Agents Possessing Soluble Epoxide Hydrolase Inhibitory Activity. Prostaglandins & Other Lipid Mediators. PMID 30593866 DOI: 10.1016/J.Prostaglandins.2018.12.003  0.605
2018 Wang K, Vasylieva N, Wan D, Eads DA, Yang J, Tretten T, Barnych B, Li J, Li QX, Gee SJ, Hammock BD, Xu T. Quantitative Detection of Fipronil and Fipronil-Sulfone in Sera of Black-Tailed Prairie Dogs and Rats after Oral Exposure to Fipronil by Camel Single-Domain Antibody-Based Immunoassays. Analytical Chemistry. PMID 30521755 DOI: 10.1021/Acs.Analchem.8B04653  0.361
2018 Lakkappa N, Krishnamurthy PT, Pandareesh MD, Hammock BD, Hwang SH. Soluble epoxide hydrolase inhibitor, APAU, protects dopaminergic neurons against rotenone induced neurotoxicity: Implications for Parkinson's disease. Neurotoxicology. PMID 30472438 DOI: 10.1016/J.Neuro.2018.11.010  0.32
2018 Zarriello S, Tuazon J, Corey S, Schimmel S, Rajani M, Gorsky A, Incontri D, Hammock BD, Borlongan CV. Humble beginnings with big goals: Small molecule soluble epoxide hydrolase inhibitors for treating CNS disorders. Progress in Neurobiology. PMID 30447256 DOI: 10.1016/J.Pneurobio.2018.11.001  0.309
2018 de Oliveira GS, Adriani PP, Wu H, Morisseau C, Hammock BD, Chambergo FS. Substrate and inhibitor selectivity, and biological activity of an epoxide hydrolase from Trichoderma reesei. Molecular Biology Reports. PMID 30426381 DOI: 10.1007/S11033-018-4481-4  0.383
2018 Kodani SD, Wan D, Wagner KM, Hwang SH, Morisseau C, Hammock BD. Design and Potency of Dual Soluble Epoxide Hydrolase/Fatty Acid Amide Hydrolase Inhibitors. Acs Omega. 3: 14076-14086. PMID 30411058 DOI: 10.1021/acsomega.8b01625  0.596
2018 Huo J, Li Z, Wan D, Li D, Qi M, Barnych B, Vasylieva N, Zhang J, Hammock BD. Development of a Highly Sensitive Direct Competitive Fluorescence Enzyme Immunoassay Based on a Nanobody-Alkaline Phosphatase Fusion Protein for Detection of 3-Phenoxybenzoic Acid in Urine. Journal of Agricultural and Food Chemistry. PMID 30293433 DOI: 10.1021/Acs.Jafc.8B04521  0.311
2018 Sun Z, Lv J, Liu X, Tang Z, Wang X, Xu Y, Hammock BD. Development of a nanobody-AviTag fusion protein and its application in a streptavidin-biotin-amplified enzyme-linked immunosorbent assay for ochratoxin A in cereal. Analytical Chemistry. PMID 30092629 DOI: 10.1021/Acs.Analchem.8B03085  0.312
2018 He J, Tian J, Xu J, Wang K, Li J, Gee SJ, Hammock BD, Li QX, Xu T. Strong and oriented conjugation of nanobodies onto magnetosomes for the development of a rapid immunomagnetic assay for the environmental detection of tetrabromobisphenol-A. Analytical and Bioanalytical Chemistry. PMID 30066195 DOI: 10.1007/S00216-018-1270-9  0.366
2018 Napimoga MH, Rocha EP, Trindade-da-Silva CA, Demasi APD, Martinez EF, Macedo CG, Abdalla HB, Bettaieb A, Haj FG, Clemente-Napimoga JT, Inceoglu B, Hammock BD. Soluble epoxide hydrolase inhibitor promotes immunomodulation to inhibit bone resorption. Journal of Periodontal Research. PMID 29851077 DOI: 10.1111/Jre.12559  0.377
2018 Harris TR, Kodani S, Rand AA, Yang J, Imai DM, Hwang SH, Hammock BD. Celecoxib does not protect against fibrosis and inflammation in a carbon tetrachloride-induced model of liver injury. Molecular Pharmacology. PMID 29844231 DOI: 10.1124/Mol.118.111831  0.302
2018 Burmistrov V, Morisseau C, Pitushkin D, Karlov D, Fayzullin RR, Butov GM, Hammock BD. Adamantyl thioureas as soluble epoxide hydrolase inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 29803731 DOI: 10.1016/J.Bmcl.2018.05.024  0.345
2018 Lee KSS, Liu JY, Wagner KM, Pakhomova S, Dong H, Morisseau C, Fu SH, Yang J, Wang P, Ulu A, Mate CA, Nguyen LV, Hwang SH, Edin ML, Mara AA, ... ... Hammock BD, et al. Correction to Optimized Inhibitors of Soluble Epoxide Hydrolase Improve in Vitro Target Residence Time and in Vivo Efficacy. Journal of Medicinal Chemistry. PMID 29701466 DOI: 10.1021/Acs.Jmedchem.8B00582  0.721
2018 Martinez JA, Yang J, Wertheim BC, Roe DJ, Schriewer A, Lance P, Alberts DS, Hammock BD, Thompson PA. Celecoxib use and circulating oxylipins in a colon polyp prevention trial. Plos One. 13: e0196398. PMID 29698447 DOI: 10.1371/Journal.Pone.0196398  0.336
2018 Cui X, Vasylieva N, Shen D, Barnych B, Yang J, He Q, Jiang Z, Zhao S, Hammock BD. Biotinylated single-chain variable fragment-based enzyme-linked immunosorbent assay for glycocholic acid. The Analyst. PMID 29629470 DOI: 10.1039/C7An02024D  0.332
2018 Blöcher R, Wagner KM, Gopireddy RR, Harris TR, Wu H, Barnych B, Hwang SH, Xiang YK, Proschak E, Morisseau C, Hammock BD. Orally available soluble epoxide hydrolase/phosphodiesterase 4 dual inhibitor treats inflammatory pain. Journal of Medicinal Chemistry. PMID 29614224 DOI: 10.1021/Acs.Jmedchem.7B01804  0.628
2018 Tu R, Armstrong J, Lee KSS, Hammock BD, Sapirstein A, Koehler RC. Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia. Scientific Reports. 8: 5279. PMID 29588470 DOI: 10.1038/S41598-018-23504-1  0.311
2018 Pecic S, Zeki AA, Xu X, Jin GY, Zhang S, Kodani S, Halim M, Morisseau C, Hammock BD, Deng SX. Novel piperidine-derived amide sEH inhibitors as mediators of lipid metabolism with improved stability. Prostaglandins & Other Lipid Mediators. PMID 29567338 DOI: 10.1016/J.Prostaglandins.2018.02.004  0.407
2018 Yamanashi H, Boeglin WE, Morisseau C, Davis RW, Sulikowski GA, Hammock BD, Brash AR. Catalytic activities of mammalian epoxide hydrolases withandfatty acid epoxides relevant to skin barrier function. Journal of Lipid Research. PMID 29459481 DOI: 10.1194/Jlr.M082701  0.342
2018 Swardfager W, Hennebelle M, Yu D, Hammock BD, Levitt AJ, Hashimoto K, Taha AY. Metabolic/inflammatory/vascular comorbidity in psychiatric disorders; soluble epoxide hydrolase (sEH) as a possible new target. Neuroscience and Biobehavioral Reviews. 87: 56-66. PMID 29407524 DOI: 10.1016/J.Neubiorev.2018.01.010  0.313
2018 Kodani SD, Bhakta S, Hwang SH, Pakhomova S, Newcomer ME, Morisseau C, Hammock BD. Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase. Bioorganic & Medicinal Chemistry Letters. PMID 29366648 DOI: 10.1016/J.Bmcl.2018.01.003  0.373
2018 Bastan I, Ge XN, Dileepan M, Greenberg YG, Guedes AG, Hwang SH, Hammock BD, Washabau RJ, Rao SP, Sriramarao P. Inhibition of soluble epoxide hydrolase attenuates eosinophil recruitment and food allergen-induced gastrointestinal inflammation. Journal of Leukocyte Biology. PMID 29345370 DOI: 10.1002/Jlb.3Ma1017-423R  0.32
2018 Zimmermann M, Hwang SH, Hammock BD, Cimino G, Henderson PT. Abstract B06: Enhancement of checkpoint inhibitor efficacy by combination treatment with a novel COX2/sEH dual inhibitor Cancer Immunology Research. 6. DOI: 10.1158/2326-6074.Tumimm17-B06  0.316
2018 Cui X, He Q, Shen D, Jiang Z, Chen Y, Zhao S, Hammock BD. Production and characterization of a single-chain variable fragment-alkaline phosphatase fusion protein for glycocholic acid detection in a one-step enzyme-linked immunosorbent assay Analytical Methods. 10: 2629-2635. DOI: 10.1039/C8Ay00848E  0.32
2017 Burmistrov V, Morisseau C, Harris TR, Butov G, Hammock BD. Effects of adamantane alterations on soluble epoxide hydrolase inhibition potency, physical properties and metabolic stability. Bioorganic Chemistry. 76: 510-527. PMID 29310082 DOI: 10.1016/J.Bioorg.2017.12.024  0.323
2017 Wang F, Zhang H, Ma AH, Yu W, Zimmermann M, Yang J, Hwang SH, Zhu D, Lin TY, Malfatti M, Turteltaub KW, Henderson PT, Airhart S, Hammock BD, Yuan J, et al. COX-2/sEH Dual Inhibitor PTUPB Potentiates the Anti-tumor Efficacy of Cisplatin. Molecular Cancer Therapeutics. PMID 29284644 DOI: 10.1158/1535-7163.Mct-16-0818  0.307
2017 Kodani SD, Barthélemy M, Kamita SG, Hammock B, Morisseau C. Development of amide-based fluorescent probes for selective measurement of carboxylesterase 1 activity in tissue extracts. Analytical Biochemistry. 539: 81-89. PMID 29054529 DOI: 10.1016/J.Ab.2017.10.014  0.331
2017 Deol P, Fahrmann J, Yang J, Evans JR, Rizo A, Grapov D, Salemi M, Wanichthanarak K, Fiehn O, Phinney B, Hammock BD, Sladek FM. Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice. Scientific Reports. 7: 12488. PMID 28970503 DOI: 10.1038/S41598-017-12624-9  0.662
2017 Yang J, Oh YT, Wan D, Watanabe RM, Hammock BD, Youn JH. Postprandial effect to decrease soluble epoxide hydrolase activity: roles of insulin and gut microbiota. The Journal of Nutritional Biochemistry. 49: 8-14. PMID 28863368 DOI: 10.1016/J.Jnutbio.2017.07.006  0.315
2017 Inceoglu B, Bettaieb A, Haj FG, Gomes AV, Hammock BD. Modulation of mitochondrial dysfunction and endoplasmic reticulum stress are key mechanisms for the wide-ranging actions of epoxy fatty acids and soluble epoxide hydrolase inhibitors. Prostaglandins & Other Lipid Mediators. PMID 28847566 DOI: 10.1016/J.Prostaglandins.2017.08.003  0.367
2017 Hasegawa E, Inafuku S, Mulki L, Okunuki Y, Yanai R, Smith KE, Kim CB, Klokman G, Bielenberg DR, Puli N, Falck JR, Husain D, Miller JW, Edin ML, Zeldin DC, ... ... Hammock BD, et al. Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization. Proceedings of the National Academy of Sciences of the United States of America. PMID 28827330 DOI: 10.1073/Pnas.1620898114  0.352
2017 Wagner KM, McReynolds CB, Schmidt WK, Hammock BD. Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases. Pharmacology & Therapeutics. PMID 28642117 DOI: 10.1016/J.Pharmthera.2017.06.006  0.638
2017 Kitamura S, Morisseau C, Harris TR, Inceoglu B, Hammock BD. Occurrence of urea-based soluble epoxide hydrolase inhibitors from the plants in the order Brassicales. Plos One. 12: e0176571. PMID 28472063 DOI: 10.1371/Journal.Pone.0176571  0.301
2017 Barnych B, Rand AA, Cajka T, Lee KSS, Hammock BD. Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs. Organic & Biomolecular Chemistry. PMID 28470279 DOI: 10.1039/C7Ob00789B  0.334
2017 Li D, Cui Y, Morisseau C, Gee SJ, Bever CRS, Liu X, Wu J, Hammock BD, Ying YB. Nanobody based Immunoassay for Human Soluble Epoxide Hydrolase Detection using PolyHRP for Signal Enhancement-the Rediscovery of PolyHRP? Analytical Chemistry. PMID 28460522 DOI: 10.1021/Acs.Analchem.7B01247  0.315
2017 Wang Z, Fang Y, Teague J, Wong H, Morisseau C, Hammock BD, Rock DA, Wang Z. In Vitro Metabolism of Oprozomib, an Oral Proteasome Inhibitor: Role of Epoxide Hydrolases and Cytochrome P450s. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 28428366 DOI: 10.1124/Dmd.117.075226  0.341
2017 Fiala M, Kooij G, Wagner K, Hammock B, Pellegrini M. Modulation of innate immunity of patients with Alzheimer's disease by omega-3 fatty acids. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28420693 DOI: 10.1096/Fj.201700065R  0.572
2017 Barnych B, Vasylieva N, Joseph T, Hulsizer S, Nguyen H, Cajka T, Pessah I, Wulff H, Gee S, Hammock B. Development of tetramethylenedisulfotetramine (TETS) hapten library: synthesis, electrophysiological studies and immune response in rabbits. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 28411375 DOI: 10.1002/Chem.201700783  0.314
2017 Chu S, Baker MR, Leong G, Letcher RJ, Gee SJ, Hammock BD, Li QX. Exploring adduct formation between human serum albumin and eleven organophosphate ester flame retardants and plasticizers using MALDI-TOF/TOF and LC-Q/TOF. Chemosphere. 180: 169-177. PMID 28407546 DOI: 10.1016/J.Chemosphere.2017.03.124  0.349
2017 Rand AA, Barnych B, Morisseau C, Cajka T, Lee KS, Panigrahy D, Hammock BD. Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids. Proceedings of the National Academy of Sciences of the United States of America. PMID 28396419 DOI: 10.1073/Pnas.1616893114  0.557
2017 Hvorecny KL, Bahl CD, Kitamura S, Lee KS, Hammock BD, Morisseau C, Madden DR. Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase. Structure (London, England : 1993). PMID 28392259 DOI: 10.1016/J.Str.2017.03.002  0.58
2017 Trindade da Silva CA, Bettaieb A, Napimoga MH, Lee KS, Inceoglu B, Ueira-Vieira C, Bruun D, Goswami SK, Haj FG, Hammock BD. Soluble epoxide hydrolase pharmacological inhibition decreases alveolar bone loss by modulating host inflammatory response, RANK-related signaling, ER stress and apoptosis. The Journal of Pharmacology and Experimental Therapeutics. PMID 28356494 DOI: 10.1124/Jpet.116.238113  0.587
2017 Islam O, Patil P, Goswami SK, Razdan R, Inamdar MN, Rizwan M, Mathew J, Inceoglu B, Lee KS, Hwang SH, Hammock BD. Inhibitors of soluble epoxide hydrolase minimize ischemia-reperfusion induced cardiac damage in normal, hypertensive and diabetic rats. Cardiovascular Therapeutics. PMID 28296232 DOI: 10.1111/1755-5922.12259  0.562
2017 Wagner K, Gilda J, Yang J, Wan D, Morisseau C, Gomes AV, Hammock BD. Soluble epoxide hydrolase inhibition alleviates neuropathy in Akita (Ins2 Akita) mice. Behavioural Brain Research. PMID 28259677 DOI: 10.1016/J.Bbr.2017.02.048  0.629
2017 Hennebelle M, Otoki Y, Yang J, Hammock BD, Levitt AJ, Taha AY, Swardfager W. Altered soluble epoxide hydrolase-derived oxylipins in patients with seasonal major depression: An exploratory study. Psychiatry Research. 252: 94-101. PMID 28259037 DOI: 10.1016/J.Psychres.2017.02.056  0.302
2017 Hu P, Wu X, Khandelwal AR, Yu W, Xu Z, Chen L, Yang J, Weisbrod RM, Lee KS, Seta F, Hammock BD, Cohen RA, Zeng C, Tong X. Endothelial Nox4-based NADPH oxidase regulates atherosclerosis via soluble epoxide hydrolase. Biochimica Et Biophysica Acta. PMID 28185955 DOI: 10.1016/J.Bbadis.2017.02.004  0.547
2017 Wan D, Yang J, Barnych B, Hwang SH, Lee KS, Cui Y, Niu J, Watsky MA, Hammock BD. A new sensitive LC/MS/MS analysis of vitamin D metabolites using a click derivatization reagent, 2-nitrosopyridine. Journal of Lipid Research. PMID 28148721 DOI: 10.1194/Jlr.D073536  0.533
2017 Lee KS, Henriksen NM, Ng CJ, Yang J, Jia W, Morisseau C, Andaya A, Gilson MK, Hammock BD. Probing the orientation of inhibitor and epoxy-eicosatrienoic acid binding in the active site of soluble epoxide hydrolase. Archives of Biochemistry and Biophysics. 613: 1-11. PMID 27983948 DOI: 10.1016/J.Abb.2016.10.017  0.583
2016 Supp DM, Hahn JM, McFarland KL, Combs KA, Lee KS, Inceoglu B, Wan D, Boyce ST, Hammock BD. Soluble Epoxide Hydrolase Inhibition and Epoxyeicosatrienoic Acid Treatment Improve Vascularization of Engineered Skin Substitutes. Plastic and Reconstructive Surgery. Global Open. 4: e1151. PMID 28293507 DOI: 10.1097/Gox.0000000000001151  0.538
2016 Ulu A, Inceoglu B, Yang J, Singh V, Vito S, Wulff H, Hammock BD. Inhibition of soluble epoxide hydrolase as a novel approach to high dose diazepam induced hypotension. Journal of Clinical Toxicology. 6. PMID 28255523 DOI: 10.4172/2161-0495.1000300  0.607
2016 Hwang SH, Wagner K, Xu J, Yang J, Li X, Cao Z, Morisseau C, Lee KS, Hammock BD. Chemical synthesis and biological evaluation of ω-hydroxy polyunsaturated fatty acids. Bioorganic & Medicinal Chemistry Letters. PMID 28025003 DOI: 10.1016/J.Bmcl.2016.12.002  0.714
2016 Zhang Y, Hong G, Lee KS, Hammock BD, Gebremedhin D, Harder DR, Koehler RC, Sapirstein A. Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after oxygen-glucose deprivation. Journal of Neurochemistry. PMID 28002622 DOI: 10.1111/Jnc.13933  0.546
2016 Wang W, Yang J, Qi W, Yang H, Wang C, Tan B, Hammock BD, Park Y, Kim D, Zhang G. Lipidomic profiling of high-fat diet-induced obesity in mice: Importance of cytochrome P450-derived fatty acid epoxides. Obesity (Silver Spring, Md.). PMID 27891824 DOI: 10.1002/Oby.21692  0.301
2016 Kodani SD, Overby HB, Morisseau C, Chen J, Zhao L, Hammock BD. Parabens inhibit fatty acid amide hydrolase: A potential role in paraben-enhanced 3T3-L1 adipocyte differentiation. Toxicology Letters. PMID 27659731 DOI: 10.1016/J.Toxlet.2016.09.011  0.34
2016 Wagner K, Lee KS, Yang J, Hammock BD. Epoxy fatty acids mediate analgesia in murine diabetic neuropathy. European Journal of Pain (London, England). PMID 27634339 DOI: 10.1002/Ejp.939  0.721
2016 Li D, Liu Y, Zhang X, Lv H, Pang W, Sun X, Gan LM, Hammock BD, Ai D, Zhu Y. Inhibition of soluble epoxide hydrolase alleviated atherosclerosis by reducing monocyte infiltration in Ldlr(-/-) mice. Journal of Molecular and Cellular Cardiology. PMID 27496380 DOI: 10.1016/J.Yjmcc.2016.08.001  0.322
2016 Gong Y, Fu Z, Edin ML, Liu CH, Wang Z, Shao Z, Fredrick TW, Saba NJ, Morss PC, Burnim SB, Meng SS, Lih FB, Stephen Lee KS, Moran EP, SanGiovanni JP, ... ... Hammock BD, et al. Cytochrome P450 Oxidase 2C Inhibition Adds to ω-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 27417579 DOI: 10.1161/Atvbaha.116.307558  0.308
2016 Xu J, Morisseau C, Yang J, Lee KS, Kamita SG, Hammock BD. Ingestion of the epoxide hydrolase inhibitor AUDA modulates immune responses of the mosquito, Culex quinquefasciatus during blood feeding. Insect Biochemistry and Molecular Biology. PMID 27369469 DOI: 10.1016/J.Ibmb.2016.06.011  0.592
2016 Guedes A, Galuppo L, Hood D, Hwang SH, Morisseau C, Hammock BD. Soluble epoxide hydrolase activity and pharmacologic inhibition in horses with chronic severe laminitis. Equine Veterinary Journal. PMID 27338788 DOI: 10.1111/Evj.12603  0.317
2016 Mouchlis VD, Morisseau C, Hammock BD, Li S, McCammon JA, Dennis EA. Computer-aided drug design guided by hydrogen/deuterium exchange mass spectrometry: A powerful combination for the development of potent and selective inhibitors of Group VIA calcium-independent phospholipase A2. Bioorganic & Medicinal Chemistry. 24: 4801-4811. PMID 27320659 DOI: 10.1016/J.Bmc.2016.05.009  0.332
2016 Sharma A, Khan MA, Levick SP, Lee KS, Hammock BD, Imig JD. Novel Omega-3 Fatty Acid Epoxygenase Metabolite Reduces Kidney Fibrosis. International Journal of Molecular Sciences. 17. PMID 27213332 DOI: 10.3390/Ijms17050751  0.553
2016 Wu X, Yang J, Morisseau C, Robertson LW, Hammock B, Lehmler HJ. 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) decreases hepatic and systemic ratios of epoxide to diol metabolites of unsaturated fatty acids in male rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 27208083 DOI: 10.1093/Toxsci/Kfw084  0.315
2016 Shu M, Xu Y, Liu X, Li Y, He Q, Tu Z, Fu J, Gee SJ, Hammock BD. Anti-idiotypic nanobody-alkaline phosphatase fusion proteins: Development of a one-step competitive enzyme immunoassay for fumonisin B1 detection in cereal. Analytica Chimica Acta. 924: 53-9. PMID 27181644 DOI: 10.1016/J.Aca.2016.03.053  0.315
2016 Sirish P, Li N, Timofeyev V, Zhang XD, Wang L, Yang J, Lee KS, Bettaieb A, Ma SM, Lee JH, Su D, Lau VC, Myers RE, Lieu DK, López JE, ... ... Hammock BD, et al. Molecular Mechanisms and New Treatment Paradigm for Atrial Fibrillation. Circulation. Arrhythmia and Electrophysiology. 9. PMID 27162031 DOI: 10.1161/Circep.115.003721  0.578
2016 Kitamura S, Hvorecny KL, Niu J, Hammock BD, Madden DR, Morisseau C. Rational design of potent and selective inhibitors of an epoxide hydrolase virulence factor from Pseudomonas aeruginosa. Journal of Medicinal Chemistry. PMID 27120257 DOI: 10.1021/Acs.Jmedchem.6B00173  0.314
2016 Ramsden CE, Ringel A, Majchrzak-Hong SF, Yang J, Blanchard H, Zamora D, Loewke JD, Rapoport SI, Hibbeln JR, Davis JM, Hammock BD, Taha AY. Dietary linoleic acid-induced alterations in pro- and anti-nociceptive lipid autacoids: Implications for idiopathic pain syndromes? Molecular Pain. 12. PMID 27030719 DOI: 10.1177/1744806916636386  0.312
2016 Goswami SK, Wan D, Yang J, Trindade da Silva CA, Morisseau C, Kodani SD, Yang GY, Inceoglu B, Hammock BD. Anti-ulcer efficacy of soluble epoxide hydrolase inhibitor TPPU on diclofenac sodium induced intestinal ulcers. The Journal of Pharmacology and Experimental Therapeutics. PMID 26989141 DOI: 10.1124/Jpet.116.232108  0.315
2016 Ren Q, Ma M, Ishima T, Morisseau C, Yang J, Wagner KM, Zhang JC, Yang C, Yao W, Dong C, Han M, Hammock BD, Hashimoto K. Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress. Proceedings of the National Academy of Sciences of the United States of America. PMID 26976569 DOI: 10.1073/Pnas.1601532113  0.564
2016 El-Sheikh el-SA, Kamita SG, Hammock BD. Effects of juvenile hormone (JH) analog insecticides on larval development and JH esterase activity in two spodopterans. Pesticide Biochemistry and Physiology. 128: 30-6. PMID 26969437 DOI: 10.1016/J.Pestbp.2015.10.008  0.323
2016 Zhou Y, Yang J, Sun GY, Liu T, Duan JX, Zhou HF, Lee KS, Hammock BD, Fang X, Jiang JX, Guan CX. Erratum to: Soluble epoxide hydrolase inhibitor 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea attenuates bleomycin-induced pulmonary fibrosis in mice. Cell and Tissue Research. PMID 26946414 DOI: 10.1007/S00441-016-2379-9  0.545
2016 Ahn KC, Ranganathan A, Bever CR, Hwang SH, Holland EB, Morisseau K, Pessah IN, Hammock BD, Gee SJ. Detection of the Antimicrobial Triclosan in Environmental Samples by Immunoassay. Environmental Science & Technology. PMID 26937944 DOI: 10.1021/Acs.Est.5B05357  0.305
2016 Zhao Y, Wan D, Yang J, Hammock BD, Ortiz De Montellano PR. Catalytic Activities of Tumor-Specific Human Cytochrome P450 CYP2W1 Towards Endogenous Substrates. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 26936974 DOI: 10.1124/Dmd.116.069633  0.313
2016 Kim J, Ulu A, Wan D, Yang J, Hammock BD, Weiss RH. Addition of DHA synergistically enhances the efficacy of regorafenib for kidney cancer therapy. Molecular Cancer Therapeutics. PMID 26921392 DOI: 10.1158/1535-7163.Mct-15-0847  0.636
2016 Tong X, Khandelwal AR, Wu X, Xu Z, Yu W, Chen C, Zhao W, Yang J, Qin Z, Weisbrod RM, Seta F, Ago T, Lee KS, Hammock BD, Sadoshima J, et al. Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase. Journal of Molecular and Cellular Cardiology. PMID 26812119 DOI: 10.1016/J.Yjmcc.2016.01.020  0.536
2016 Liao J, Xia R, Yang J, Li H, Xu D, Wang X, You X, Hwang SH, Hammock B, Yang G. Abstract LB-299: Enhanced inhibitory effects on mutant KrasG12D-initiated murine pancreatic carcinoma growth in Fat-1 transgenic mice treated with soluble epoxide hydrolase inhibitor t-AUCB Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-299  0.345
2016 Burmistrov VV, Butov GM, Karlov DS, Palyulin VA, Zefirov NS, Morisseau C, Hammock BD. Synthesis and properties of diadamantyl-containing symmetric diureas as target-oriented inhibitors of human soluble epoxide hydrolase Russian Journal of Bioorganic Chemistry. 42: 404-414. DOI: 10.1134/S1068162016030067  0.333
2016 Butov GM, Burmistrov VV, Danilov DV, Averin AD, Morisseau C, Kodani S, Hammock BD. Synthesis of epoxide hydrolase sEH inhibitors and study of its inhibitory properties Russian Chemical Bulletin. 65: 2299-2305. DOI: 10.1007/S11172-016-1581-Y  0.337
2015 Liao J, Hwang SH, Li H, Yang Y, Yang J, Wecksler AT, Liu JY, Hammock BD, Yang GY. Inhibition of mutant Kras(G12D) -initiated murine pancreatic carcinoma growth by a dual c-Raf and soluble epoxide hydrolase inhibitor t-CUPM. Cancer Letters. PMID 26683769 DOI: 10.1016/J.Canlet.2015.11.042  0.321
2015 Rossotti MA, Pirez M, González-Techera A, Cui Y, Bever CR, Lee KS, Morisseau C, Leizagoyen C, Gee SJ, Hammock BD, Gonzalez-Sapienza GG. A method for sorting and pairwise selection of nanobodies for the development of highly sensitive sandwich immunoassays. Analytical Chemistry. PMID 26544909 DOI: 10.1021/Acs.Analchem.5B03561  0.549
2015 Goswami SK, Inceoglu B, Yang J, Wan D, Kodani SD, da Silva CA, Morisseau C, Hammock BD. Omeprazole increases the efficacy of a soluble epoxide hydrolase inhibitor in a PGE2 induced pain model. Toxicology and Applied Pharmacology. PMID 26522832 DOI: 10.1016/J.Taap.2015.10.018  0.312
2015 Burmistrov V, Morisseau C, Danilov D, Harris TR, Dalinger I, Vatsadze I, Shkineva T, Butov GM, Hammock BD. 1,3-Disubstituted and 1,3,3-trisubstituted adamantyl-ureas with isoxazole as soluble epoxide hydrolase inhibitors. Bioorganic & Medicinal Chemistry Letters. 25: 5514-9. PMID 26520661 DOI: 10.1016/J.Bmcl.2015.10.066  0.341
2015 Kim IH, Park YK, Nishiwaki H, Hammock BD, Nishi K. Structure-activity relationships of amide-phosphonate derivatives as inhibitors of the human soluble epoxide hydrolase. Bioorganic & Medicinal Chemistry. 23: 7199-210. PMID 26507430 DOI: 10.1016/J.Bmc.2015.10.016  0.331
2015 Liu JY, Tsai HJ, Morisseau C, Lango J, Hwang SH, Watanabe T, Kim IH, Hammock BD. In vitro and in vivo metabolism of N-adamantyl substituted urea-based soluble epoxide hydrolase inhibitors. Biochemical Pharmacology. PMID 26494425 DOI: 10.1016/J.Bcp.2015.10.013  0.577
2015 Wang Q, Huo L, He J, Ding W, Su H, Tian D, Welch C, Hammock B, Ai D, Zhu Y. Soluble epoxide hydrolase is involved in the development of atherosclerosis and arterial neointima formation by regulating smooth muscle cell migration. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00289.2015. PMID 26453326 DOI: 10.1152/Ajpheart.00289.2015  0.309
2015 Hua X, Zhou L, Feng L, Ding Y, Shi H, Wang L, Gee SJ, Hammock BD, Wang M. Competitive and noncompetitive phage immunoassays for the determination of benzothiostrobin. Analytica Chimica Acta. 890: 150-6. PMID 26347177 DOI: 10.1016/J.Aca.2015.07.056  0.307
2015 Zhou Y, Sun GY, Liu T, Duan JX, Zhou HF, Lee KS, Hammock BD, Fang X, Jiang JX, Guan CX. Soluble epoxide hydrolase inhibitor 1-trifluoromethoxyphenyl-3- (1-propionylpiperidin-4-yl) urea attenuates bleomycin-induced pulmonary fibrosis in mice. Cell and Tissue Research. PMID 26310139 DOI: 10.1007/S00441-015-2262-0  0.563
2015 Cui Y, Li D, Morisseau C, Dong JX, Yang J, Wan D, Rossotti MA, Gee SJ, González-Sapienza GG, Hammock BD. Heavy chain single-domain antibodies to detect native human soluble epoxide hydrolase. Analytical and Bioanalytical Chemistry. PMID 26229025 DOI: 10.1007/S00216-015-8889-6  0.336
2015 Vasylieva N, Ahn KC, Barnych B, Gee SJ, Hammock BD. Development of an Immunoassay for the Detection of the Phenylpyrazole Insecticide Fipronil. Environmental Science & Technology. PMID 26196357 DOI: 10.1021/Acs.Est.5B01005  0.305
2015 Hwang VJ, Kim J, Rand A, Yang C, Sturdivant S, Hammock B, Bell PD, Guay-Woodford LM, Weiss RH. The cpk model of recessive PKD shows glutamine-dependence associated with the production of the oncometabolite 2-hydroxyglutarate. American Journal of Physiology. Renal Physiology. ajprenal.00238.2015. PMID 26155843 DOI: 10.1152/Ajprenal.00238.2015  0.305
2015 Inceoglu B, Bettaieb A, Trindade da Silva CA, Lee KS, Haj FG, Hammock BD. Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain. Proceedings of the National Academy of Sciences of the United States of America. PMID 26150506 DOI: 10.1073/Pnas.1510137112  0.545
2015 Ostermann AI, Herbers J, Willenberg I, Chen R, Hwang SH, Greite R, Morisseau C, Gueler F, Hammock BD, Schebb NH. Oral treatment of rodents with soluble epoxide hydrolase inhibitor 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU): Resulting drug levels and modulation of oxylipin pattern. Prostaglandins & Other Lipid Mediators. PMID 26117215 DOI: 10.1016/J.Prostaglandins.2015.06.005  0.344
2015 Thomson S, Edin ML, Lih FB, Davies M, Yaqoob MM, Hammock BD, Gilroy D, Zeldin DC, Bishop-Bailey D. Intimal smooth muscle cells are a source but not a sensor of anti-inflammatory CYP450 derived oxylipins. Biochemical and Biophysical Research Communications. PMID 26086108 DOI: 10.1016/J.Bbrc.2015.06.012  0.33
2015 ?ervenka L, Melenovský V, Husková Z, Sporková A, Bürgelová M, Škaroupková P, Hwang SH, Hammock BD, Imig JD, Sadowski J. Inhibition of soluble epoxide hydrolase does not improve the course of congestive heart failure and the development of renal dysfunction in rats with volume overload induced by aorto-caval fistula. Physiological Research / Academia Scientiarum Bohemoslovaca. PMID 26047375 DOI: 10.33549/Physiolres.932977  0.309
2015 Sasso O, Wagner K, Morisseau C, Inceoglu B, Hammock BD, Piomelli D. Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 97: 7-15. PMID 25882247 DOI: 10.1016/J.Phrs.2015.04.001  0.654
2015 Fahrmann J, Grapov D, Yang J, Hammock B, Fiehn O, Bell GI, Hara M. Systemic alterations in the metabolome of diabetic NOD mice delineate increased oxidative stress accompanied by reduced inflammation and hypertriglyceremia. American Journal of Physiology. Endocrinology and Metabolism. 308: E978-89. PMID 25852003 DOI: 10.1152/Ajpendo.00019.2015  0.684
2015 Harris TR, Bettaieb A, Kodani S, Dong H, Myers R, Chiamvimonvat N, Haj FG, Hammock BD. Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice. Toxicology and Applied Pharmacology. 286: 102-11. PMID 25827057 DOI: 10.1016/J.Taap.2015.03.022  0.315
2015 Shih PB, Yang J, Morisseau C, German JB, Zeeland AA, Armando AM, Quehenberger O, Bergen AW, Magistretti P, Berrettini W, Halmi KA, Schork N, Hammock BD, Kaye W. Dysregulation of soluble epoxide hydrolase and lipidomic profiles in anorexia nervosa. Molecular Psychiatry. PMID 25824304 DOI: 10.1038/Mp.2015.26  0.344
2015 Kodani SD, Hammock BD. The 2014 Bernard B. Brodie award lecture-epoxide hydrolases: drug metabolism to therapeutics for chronic pain. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 43: 788-802. PMID 25762541 DOI: 10.1124/Dmd.115.063339  0.316
2015 Saito Y, Kamita SG, Hammock BD, Kunimi Y, Inoue MN, Nakai M. Juvenile hormone (JH) esterase activity but not JH epoxide hydrolase activity is downregulated in larval Adoxophyes honmai following nucleopolyhedroviruses infection. Journal of Insect Physiology. PMID 25727179 DOI: 10.1016/J.Jinsphys.2015.02.005  0.304
2015 Xu J, Morisseau C, Yang J, Mamatha DM, Hammock BD. Epoxide hydrolase activities and epoxy fatty acids in the mosquito Culex quinquefasciatus. Insect Biochemistry and Molecular Biology. 59: 41-9. PMID 25686802 DOI: 10.1016/J.Ibmb.2015.02.004  0.375
2015 Kitamura S, Morisseau C, Inceoglu B, Kamita SG, De Nicola GR, Nyegue M, Hammock BD. Potent natural soluble epoxide hydrolase inhibitors from Pentadiplandra brazzeana baillon: synthesis, quantification, and measurement of biological activities in vitro and in vivo. Plos One. 10: e0117438. PMID 25659109 DOI: 10.1371/Journal.Pone.0117438  0.35
2015 López-Vicario C, Alcaraz-Quiles J, García-Alonso V, Rius B, Hwang SH, Titos E, Lopategi A, Hammock BD, Arroyo V, Clària J. Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: role for omega-3 epoxides. Proceedings of the National Academy of Sciences of the United States of America. 112: 536-41. PMID 25550510 DOI: 10.1073/Pnas.1422590112  0.316
2015 Shihadih DS, Harris TR, Yang J, Merzlikin O, Lee KS, Hammock BD, Morisseau C. Identification of potent inhibitors of the chicken soluble epoxide hydrolase. Bioorganic & Medicinal Chemistry Letters. 25: 276-9. PMID 25479771 DOI: 10.1016/J.Bmcl.2014.11.053  0.606
2015 Wecksler AT, Hwang SH, Liu JY, Wettersten HI, Morisseau C, Wu J, Weiss RH, Hammock BD. Biological evaluation of a novel sorafenib analogue, t-CUPM. Cancer Chemotherapy and Pharmacology. 75: 161-71. PMID 25413440 DOI: 10.1007/S00280-014-2626-2  0.308
2015 Kim J, Yoon SP, Toews ML, Imig JD, Hwang SH, Hammock BD, Padanilam BJ. Pharmacological inhibition of soluble epoxide hydrolase prevents renal interstitial fibrogenesis in obstructive nephropathy. American Journal of Physiology. Renal Physiology. 308: F131-9. PMID 25377915 DOI: 10.1152/Ajprenal.00531.2014  0.318
2015 Miller JA, Werthiem B, Yang J, Hammock B, Roe D, Stopeck A, Thompson PA. Abstract 1903: Application of lipidomics to a sulindac intervention of aromatase inhibitor-induced pain Cancer Research. 75: 1903-1903. DOI: 10.1158/1538-7445.Am2015-1903  0.327
2015 Butov GM, Burmistrov VV, Danilov DV, Pitushkin DA, Morisseau C, Hammock BD. Synthesis of adamantyl-containing 1,3-disubstituted diureas and thioureas, efficient targeted inhibitors of human soluble epoxide hydrolase Russian Chemical Bulletin. 64: 1569-1575. DOI: 10.1007/S11172-015-1043-Y  0.336
2014 Piomelli D, Hohmann AG, Seybold V, Hammock BD. A lipid gate for the peripheral control of pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 15184-91. PMID 25392487 DOI: 10.1523/Jneurosci.3475-14.2014  0.304
2014 Samokhvalov V, Zlobine I, Jamieson KL, Jurasz P, Chen C, Lee KS, Hammock BD, Seubert JM. PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. Toxicology Letters. 232: 10-20. PMID 25300478 DOI: 10.1016/J.Toxlet.2014.09.029  0.592
2014 Wagner K, Vito S, Inceoglu B, Hammock BD. The role of long chain fatty acids and their epoxide metabolites in nociceptive signaling. Prostaglandins & Other Lipid Mediators. 113: 2-12. PMID 25240260 DOI: 10.1016/J.Prostaglandins.2014.09.001  0.63
2014 Sporková A, Jíchová S, Husková Z, Kopkan L, Nishiyama A, Hwang SH, Hammock BD, Imig JD, Kompanowska-Jezierska E, Sadowski J, Kramer HJ, Cervenka L. Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: studies in Cyp1a1-Ren-2 transgenic rats. Clinical and Experimental Pharmacology & Physiology. 41: 1003-13. PMID 25224811 DOI: 10.1111/1440-1681.12310  0.334
2014 Terry CM, Carlson ML, He Y, Ulu A, Morisseau C, Blumenthal DK, Hammock BD, Cheung AK. Aberrant soluble epoxide hydrolase and oxylipin levels in a porcine arteriovenous graft stenosis model. Journal of Vascular Research. 51: 269-82. PMID 25196102 DOI: 10.1159/000365251  0.648
2014 Xu J, Morisseau C, Hammock BD. Expression and characterization of an epoxide hydrolase from Anopheles gambiae with high activity on epoxy fatty acids. Insect Biochemistry and Molecular Biology. 54: 42-52. PMID 25173592 DOI: 10.1016/J.Ibmb.2014.08.004  0.389
2014 Kim J, Imig JD, Yang J, Hammock BD, Padanilam BJ. Inhibition of soluble epoxide hydrolase prevents renal interstitial fibrosis and inflammation. American Journal of Physiology. Renal Physiology. 307: F971-80. PMID 25164080 DOI: 10.1152/Ajprenal.00256.2014  0.303
2014 Lee KS, Liu JY, Wagner KM, Pakhomova S, Dong H, Morisseau C, Fu SH, Yang J, Wang P, Ulu A, Mate CA, Nguyen LV, Hwang SH, Edin ML, Mara AA, ... ... Hammock BD, et al. Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy. Journal of Medicinal Chemistry. 57: 7016-30. PMID 25079952 DOI: 10.1021/Jm500694P  0.785
2014 Wang W, Zhu J, Lyu F, Panigrahy D, Ferrara KW, Hammock B, Zhang G. ω-3 polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer. Prostaglandins & Other Lipid Mediators. 113: 13-20. PMID 25019221 DOI: 10.1016/J.Prostaglandins.2014.07.002  0.325
2014 Sarnpitak P, Mujumdar P, Morisseau C, Hwang SH, Hammock B, Iurchenko V, Zozulya S, Gavalas A, Geronikaki A, Ivanenkov Y, Krasavin M. Potent, orally available, selective COX-2 inhibitors based on 2-imidazoline core. European Journal of Medicinal Chemistry. 84: 160-72. PMID 25016374 DOI: 10.1016/J.Ejmech.2014.07.023  0.329
2014 Wagner K, Yang J, Inceoglu B, Hammock BD. Soluble epoxide hydrolase inhibition is antinociceptive in a mouse model of diabetic neuropathy. The Journal of Pain : Official Journal of the American Pain Society. 15: 907-14. PMID 24924124 DOI: 10.1016/J.Jpain.2014.05.008  0.625
2014 Zhao C, Hwang SH, Buchholz BA, Carpenter TS, Lightstone FC, Lightstone F, Yang J, Hammock BD, Casida JE. GABAA receptor target of tetramethylenedisulfotetramine. Proceedings of the National Academy of Sciences of the United States of America. 111: 8607-12. PMID 24912155 DOI: 10.1073/Pnas.1407379111  0.439
2014 Schebb NH, Ostermann AI, Yang J, Hammock BD, Hahn A, Schuchardt JP. Comparison of the effects of long-chain omega-3 fatty acid supplementation on plasma levels of free and esterified oxylipins. Prostaglandins & Other Lipid Mediators. 113: 21-9. PMID 24880049 DOI: 10.1016/J.Prostaglandins.2014.05.002  0.313
2014 Charles RL, Rudyk O, Prysyazhna O, Kamynina A, Yang J, Morisseau C, Hammock BD, Freeman BA, Eaton P. Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase. Proceedings of the National Academy of Sciences of the United States of America. 111: 8167-72. PMID 24843165 DOI: 10.1073/Pnas.1402965111  0.365
2014 Morisseau C, Wecksler AT, Deng C, Dong H, Yang J, Lee KS, Kodani SD, Hammock BD. Effect of soluble epoxide hydrolase polymorphism on substrate and inhibitor selectivity and dimer formation. Journal of Lipid Research. 55: 1131-1138. PMID 24771868 DOI: 10.1194/Jlr.M049718  0.597
2014 Schebb NH, Muvvala JB, Morin D, Buckpitt AR, Hammock BD, Rice RH. Metabolic activation of the antibacterial agent triclocarban by cytochrome P450 1A1 yielding glutathione adducts. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 1098-102. PMID 24733789 DOI: 10.1124/Dmd.114.058206  0.336
2014 Li L, Li N, Pang W, Zhang X, Hammock BD, Ai D, Zhu Y. Opposite effects of gene deficiency and pharmacological inhibition of soluble epoxide hydrolase on cardiac fibrosis. Plos One. 9: e94092. PMID 24718617 DOI: 10.1371/Journal.Pone.0094092  0.32
2014 Ulu A, Stephen Lee KS, Miyabe C, Yang J, Hammock BG, Dong H, Hammock BD. An omega-3 epoxide of docosahexaenoic acid lowers blood pressure in angiotensin-II-dependent hypertension. Journal of Cardiovascular Pharmacology. 64: 87-99. PMID 24691274 DOI: 10.1097/Fjc.0000000000000094  0.641
2014 Burmistrov V, Morisseau C, Lee KS, Shihadih DS, Harris TR, Butov GM, Hammock BD. Symmetric adamantyl-diureas as soluble epoxide hydrolase inhibitors. Bioorganic & Medicinal Chemistry Letters. 24: 2193-7. PMID 24685540 DOI: 10.1016/J.Bmcl.2014.03.016  0.571
2014 Kálai T, Altman R, Maezawa I, Balog M, Morisseau C, Petrlova J, Hammock BD, Jin LW, Trudell JR, Voss JC, Hideg K. Synthesis and functional survey of new Tacrine analogs modified with nitroxides or their precursors. European Journal of Medicinal Chemistry. 77: 343-50. PMID 24657571 DOI: 10.1016/J.Ejmech.2014.03.026  0.313
2014 Hammock BD, Wagner K, Inceoglu B. The soluble epoxide hydrolase as a pharmaceutical target for pain management. Pain Management. 1: 383-6. PMID 24645702 DOI: 10.2217/Pmt.11.47  0.665
2014 Wecksler AT, Hwang SH, Wettersten HI, Gilda JE, Patton A, Leon LJ, Carraway KL, Gomes AV, Baar K, Weiss RH, Hammock BD. Novel sorafenib-based structural analogues: in-vitro anticancer evaluation of t-MTUCB and t-AUCMB. Anti-Cancer Drugs. 25: 433-46. PMID 24525589 DOI: 10.1097/Cad.0000000000000079  0.306
2014 Kujal P, ?ertíková Chábová V, Škaroupková P, Husková Z, Vernerová Z, Kramer HJ, Walkowska A, Kompanowska-Jezierska E, Sadowski J, Kitada K, Nishiyama A, Hwang SH, Hammock BD, Imig JD, ?ervenka L. Inhibition of soluble epoxide hydrolase is renoprotective in 5/6 nephrectomized Ren-2 transgenic hypertensive rats. Clinical and Experimental Pharmacology & Physiology. 41: 227-37. PMID 24471737 DOI: 10.1111/1440-1681.12204  0.326
2014 Kim IH, Lee IH, Nishiwaki H, Hammock BD, Nishi K. Structure-activity relationships of substituted oxyoxalamides as inhibitors of the human soluble epoxide hydrolase. Bioorganic & Medicinal Chemistry. 22: 1163-75. PMID 24433964 DOI: 10.1016/J.Bmc.2013.12.027  0.335
2014 Schuchardt JP, Schmidt S, Kressel G, Willenberg I, Hammock BD, Hahn A, Schebb NH. Modulation of blood oxylipin levels by long-chain omega-3 fatty acid supplementation in hyper- and normolipidemic men. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 90: 27-37. PMID 24411718 DOI: 10.1016/J.Plefa.2013.12.008  0.302
2014 Zhang G, Kodani S, Hammock BD. Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer. Progress in Lipid Research. 53: 108-23. PMID 24345640 DOI: 10.1016/J.Plipres.2013.11.003  0.328
2014 Miller JA, Yang J, Hammock B, Lance P, Ashbeck E, Thompson PA. Abstract 1867: Application of oxylipin metabolomics to a celecoxib intervention in men at risk for colorectal neoplasia recurrence Cancer Research. 74: 1867-1867. DOI: 10.1158/1538-7445.Am2014-1867  0.331
2014 Liao J, Zhang W, Hwng SH, Li H, Wecksler AT, Ma K, Hammock BD, Yang G. Abstract 1250: Inhibition of pancreatic carcinogenesis by t-CUPM, a dual inhibitor of c-Raf and soluble epoxide hydrolase Cancer Research. 74: 1250-1250. DOI: 10.1158/1538-7445.Am2014-1250  0.318
2014 Zhao C, Hwang SH, Buchholz BA, Carpenter TS, Lightstone F, Yang J, Hammock BD, Casida JE. GABAA receptor target of tetramethylenedisulfotetramine (Proceedings of the National Academy of Sciences of the United States of America (2014) 111 (8607-8612) DOI: 10.1073/pnas.1407379111) Proceedings of the National Academy of Sciences of the United States of America. 111: 11223. DOI: 10.1073/Pnas.1412593111  0.382
2013 Inceoglu B, Zolkowska D, Yoo HJ, Wagner KM, Yang J, Hackett E, Hwang SH, Lee KS, Rogawski MA, Morisseau C, Hammock BD. Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures. Plos One. 8: e80922. PMID 24349022 DOI: 10.1371/Journal.Pone.0080922  0.706
2013 Yang J, Solaimani P, Dong H, Hammock B, Hankinson O. Treatment of mice with 2,3,7,8-Tetrachlorodibenzo-p-dioxin markedly increases the levels of a number of cytochrome P450 metabolites of omega-3 polyunsaturated fatty acids in the liver and lung. The Journal of Toxicological Sciences. 38: 833-6. PMID 24213002 DOI: 10.2131/Jts.38.833  0.325
2013 Lee AR, Pechenino AS, Dong H, Hammock BD, Knowlton AA. Aging, estrogen loss and epoxyeicosatrienoic acids (EETs). Plos One. 8: e70719. PMID 23967089 DOI: 10.1371/Journal.Pone.0070719  0.319
2013 Van Bogaert I, Zhang G, Yang J, Liu JY, Ye Y, Soetaert W, Hammock BD. Preparation of 20-HETE using multifunctional enzyme type 2-negative Starmerella bombicola. Journal of Lipid Research. 54: 3215-9. PMID 23966667 DOI: 10.1194/Jlr.D042226  0.364
2013 Lundström SL, Yang J, Brannan JD, Haeggström JZ, Hammock BD, Nair P, O'Byrne P, Dahlén SE, Wheelock CE. Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega-3 fatty acids. Molecular Nutrition & Food Research. 57: 1378-89. PMID 23824870 DOI: 10.1002/Mnfr.201200827  0.538
2013 Frolov A, Dong H, Jiang M, Yang L, Cook EC, Matnani R, Hammock BD, Crofford LJ. Niemann-pick type C2 deficiency in human fibroblasts confers robust and selective activation of prostaglandin E2 biosynthesis. The Journal of Biological Chemistry. 288: 23696-703. PMID 23814065 DOI: 10.1074/Jbc.M112.445916  0.34
2013 Hwang SH, Wecksler AT, Zhang G, Morisseau C, Nguyen LV, Fu SH, Hammock BD. Synthesis and biological evaluation of sorafenib- and regorafenib-like sEH inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 3732-7. PMID 23726028 DOI: 10.1016/J.Bmcl.2013.05.011  0.33
2013 Kamita SG, Oshita GH, Wang P, Morisseau C, Hammock BD, Nandety RS, Falk BW. Characterization of Hovi-mEH1, a microsomal epoxide hydrolase from the glassy-winged sharpshooter Homalodisca vitripennis. Archives of Insect Biochemistry and Physiology. 83: 171-9. PMID 23704009 DOI: 10.1002/Arch.21100  0.318
2013 Harris TR, Hammock BD. Soluble epoxide hydrolase: gene structure, expression and deletion. Gene. 526: 61-74. PMID 23701967 DOI: 10.1016/J.Gene.2013.05.008  0.328
2013 Schuchardt JP, Schmidt S, Kressel G, Dong H, Willenberg I, Hammock BD, Hahn A, Schebb NH. Comparison of free serum oxylipin concentrations in hyper- vs. normolipidemic men. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 89: 19-29. PMID 23694766 DOI: 10.1016/J.Plefa.2013.04.001  0.318
2013 Morisseau C, Pakhomova S, Hwang SH, Newcomer ME, Hammock BD. Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides. Bioorganic & Medicinal Chemistry Letters. 23: 3818-21. PMID 23684894 DOI: 10.1016/J.Bmcl.2013.04.083  0.374
2013 Ulu A, Harris TR, Morisseau C, Miyabe C, Inoue H, Schuster G, Dong H, Iosif AM, Liu JY, Weiss RH, Chiamvimonvat N, Imig JD, Hammock BD. Anti-inflammatory effects of ω-3 polyunsaturated fatty acids and soluble epoxide hydrolase inhibitors in angiotensin-II-dependent hypertension. Journal of Cardiovascular Pharmacology. 62: 285-97. PMID 23676336 DOI: 10.1097/Fjc.0B013E318298E460  0.655
2013 de Medina P, Paillasse MR, Segala G, Voisin M, Mhamdi L, Dalenc F, Lacroix-Triki M, Filleron T, Pont F, Saati TA, Morisseau C, Hammock BD, Silvente-Poirot S, Poirot M. Dendrogenin A arises from cholesterol and histamine metabolism and shows cell differentiation and anti-tumour properties. Nature Communications. 4: 1840. PMID 23673625 DOI: 10.1038/Ncomms2835  0.301
2013 Poli G, Corda E, Martino PA, Dall'ara P, Bareggi SR, Bondiolotti G, Iulini B, Mazza M, Casalone C, Hwang SH, Hammock BD, Inceoglu B. Therapeutic activity of inhibition of the soluble epoxide hydrolase in a mouse model of scrapie. Life Sciences. 92: 1145-50. PMID 23651659 DOI: 10.1016/J.Lfs.2013.04.014  0.336
2013 Zhang G, Panigrahy D, Mahakian LM, Yang J, Liu JY, Stephen Lee KS, Wettersten HI, Ulu A, Hu X, Tam S, Hwang SH, Ingham ES, Kieran MW, Weiss RH, Ferrara KW, ... Hammock BD, et al. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. Proceedings of the National Academy of Sciences of the United States of America. 110: 6530-5. PMID 23553837 DOI: 10.1073/Pnas.1304321110  0.645
2013 Sirish P, Li N, Liu JY, Lee KS, Hwang SH, Qiu H, Zhao C, Ma SM, López JE, Hammock BD, Chiamvimonvat N. Unique mechanistic insights into the beneficial effects of soluble epoxide hydrolase inhibitors in the prevention of cardiac fibrosis. Proceedings of the National Academy of Sciences of the United States of America. 110: 5618-23. PMID 23493561 DOI: 10.1073/Pnas.1221972110  0.522
2013 Guedes AG, Morisseau C, Sole A, Soares JH, Ulu A, Dong H, Hammock BD. Use of a soluble epoxide hydrolase inhibitor as an adjunctive analgesic in a horse with laminitis. Veterinary Anaesthesia and Analgesia. 40: 440-8. PMID 23463912 DOI: 10.1111/Vaa.12030  0.638
2013 Hwang SH, Wecksler AT, Wagner K, Hammock BD. Rationally designed multitarget agents against inflammation and pain. Current Medicinal Chemistry. 20: 1783-99. PMID 23410172 DOI: 10.2174/0929867311320130013  0.64
2013 Liu JY, Lin YP, Qiu H, Morisseau C, Rose TE, Hwang SH, Chiamvimonvat N, Hammock BD. Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 48: 619-27. PMID 23291046 DOI: 10.1016/J.Ejps.2012.12.013  0.349
2013 Kamita SG, Yamamoto K, Dadala MM, Pha K, Morisseau C, Escaich A, Hammock BD. Cloning and characterization of a microsomal epoxide hydrolase from Heliothis virescens Insect Biochemistry and Molecular Biology. 43: 219-228. PMID 23276675 DOI: 10.1016/J.Ibmb.2012.12.002  0.367
2013 Wagner K, Inceoglu B, Dong H, Yang J, Hwang SH, Jones P, Morisseau C, Hammock BD. Comparative efficacy of 3 soluble epoxide hydrolase inhibitors in rat neuropathic and inflammatory pain models. European Journal of Pharmacology. 700: 93-101. PMID 23276668 DOI: 10.1016/J.Ejphar.2012.12.015  0.625
2013 Chen L, Fan C, Zhang Y, Bakri M, Dong H, Morisseau C, Maddipati KR, Luo P, Wang CY, Hammock BD, Wang MH. Beneficial effects of inhibition of soluble epoxide hydrolase on glucose homeostasis and islet damage in a streptozotocin-induced diabetic mouse model. Prostaglandins & Other Lipid Mediators. 104: 42-8. PMID 23247129 DOI: 10.1016/J.Prostaglandins.2012.12.001  0.325
2013 Pecic S, Pakhomova S, Newcomer ME, Morisseau C, Hammock BD, Zhu Z, Rinderspacher A, Deng SX. Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors Bioorganic and Medicinal Chemistry Letters. 23: 417-421. PMID 23237835 DOI: 10.1016/J.Bmcl.2012.11.084  0.367
2013 Lee KSS, Morisseau C, Yang J, Wang P, Hwang SH, Hammock BD. Förster resonance energy transfer competitive displacement assay for human soluble epoxide hydrolase Analytical Biochemistry. 434: 259-268. PMID 23219719 DOI: 10.1016/J.Ab.2012.11.015  0.354
2013 Morisseau C, Sahdeo S, Cortopassi G, Hammock BD. Development of an HTS assay for EPHX2 phosphatase activity and screening of nontargeted libraries Analytical Biochemistry. 434: 105-111. PMID 23219563 DOI: 10.1016/J.Ab.2012.11.017  0.375
2013 Kundu S, Roome T, Bhattacharjee A, Carnevale KA, Yakubenko VP, Zhang R, Hwang SH, Hammock BD, Cathcart MK. Metabolic products of soluble epoxide hydrolase are essential for monocyte chemotaxis to MCP-1 in vitro and in vivo. Journal of Lipid Research. 54: 436-47. PMID 23160182 DOI: 10.1194/Jlr.M031914  0.382
2013 Morisseau C, Hammock BD. Measurement of soluble epoxide hydrolase (sEH) activity. Current Protocols in Toxicology. Unit 4.23. PMID 23045145 DOI: 10.1002/0471140856.Tx0423S33  0.355
2013 Morisseau C, Hammock BD. Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health Annual Review of Pharmacology and Toxicology. 53: 37-58. PMID 23020295 DOI: 10.1146/Annurev-Pharmtox-011112-140244  0.343
2013 Xu DY, Davis BB, Wang ZH, Zhao SP, Wasti B, Liu ZL, Li N, Morisseau C, Chiamvimonvat N, Hammock BD. A potent soluble epoxide hydrolase inhibitor, t-AUCB, acts through PPARγ to modulate the function of endothelial progenitor cells from patients with acute myocardial infarction International Journal of Cardiology. 167: 1298-1304. PMID 22525341 DOI: 10.1016/J.Ijcard.2012.03.167  0.301
2013 Guedes AG, Hood D, Liu J, Morisseau C, Hammock B. Epoxygenated fatty acid profile and soluble epoxide hydrolase (sEH) activity in healthy and laminitic horses Journal of Equine Veterinary Science. 33: 868. DOI: 10.1016/J.Jevs.2013.08.050  0.316
2013 Guedes AG, Soares JH, Knych H, Morisseau C, Hammock B. Potency, pharmacokinetics, and physiologic effects of a soluble epoxide hydrolase inhibitor in horses Journal of Equine Veterinary Science. 33: 867-868. DOI: 10.1016/J.Jevs.2013.08.049  0.335
2012 Jiang H, Harrison FE, Jain K, Benjamin S, May JM, Graves JP, Zeldin DC, Falck JR, Hammock BD, McGiff JC. Vitamin C activation of the biosynthesis of epoxyeicosatrienoic acids. Advances in Bioscience and Biotechnology (Print). 3: 204-218. PMID 24660109 DOI: 10.4236/Abb.2012.33029  0.338
2012 Zivkovic AM, Yang J, Georgi K, Hegedus C, Nording ML, O'Sullivan A, German JB, Hogg RJ, Weiss RH, Bay C, Hammock BD. Serum oxylipin profiles in IgA nephropathy patients reflect kidney functional alterations. Metabolomics : Official Journal of the Metabolomic Society. 8: 1102-1113. PMID 23833568 DOI: 10.1007/S11306-012-0417-5  0.317
2012 Thiphom S, Prapamontol T, Chantara S, Mangklabruks A, Suphavilai C, Ahn KC, Gee SJ, Hammock BD. An enzyme-linked immunosorbent assay for detecting 3-phenoxybenzoic acid in plasma and its application in farmers and consumers. Analytical Methods : Advancing Methods and Applications. 4: 3772-3778. PMID 23667388 DOI: 10.1039/C2Ay25642H  0.314
2012 Huang H, Yao H, Liu JY, Samra AI, Kamita SG, Cornel AJ, Hammock BD. Development of pyrethroid-like fluorescent substrates for glutathione S-transferase Analytical Biochemistry. 431: 77-83. PMID 23000005 DOI: 10.1016/J.Ab.2012.09.011  0.32
2012 Kopkan L, Husková Z, Sporková A, Varcabová Š, Honetschlägerová Z, Hwang SH, Tsai HJ, Hammock BD, Imig JD, Kramer HJ, Bürgelová M, Vojtíšková A, Kujal P, Vernerová Z, Červenka L. Soluble epoxide hydrolase inhibition exhibits antihypertensive actions independently of nitric oxide in mice with renovascular hypertension. Kidney & Blood Pressure Research. 35: 595-607. PMID 22948718 DOI: 10.1159/000339883  0.567
2012 Kim IH, Nishi K, Kasagami T, Morisseau C, Liu JY, Tsai HJ, Hammock BD. Biologically active ester derivatives as potent inhibitors of the soluble epoxide hydrolase. Bioorganic & Medicinal Chemistry Letters. 22: 5889-92. PMID 22901393 DOI: 10.1016/J.Bmcl.2012.07.074  0.591
2012 Decker M, Adamska M, Cronin A, Di Giallonardo F, Burgener J, Marowsky A, Falck JR, Morisseau C, Hammock BD, Gruzdev A, Zeldin DC, Arand M. EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides. Journal of Lipid Research. 53: 2038-45. PMID 22798687 DOI: 10.1194/Jlr.M024448  0.384
2012 Inceoglu B, Wagner KM, Yang J, Bettaieb A, Schebb NH, Hwang SH, Morisseau C, Haj FG, Hammock BD. Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of type I diabetes. Proceedings of the National Academy of Sciences of the United States of America. 109: 11390-5. PMID 22733772 DOI: 10.1073/Pnas.1208708109  0.621
2012 Frömel T, Jungblut B, Hu J, Trouvain C, Barbosa-Sicard E, Popp R, Liebner S, Dimmeler S, Hammock BD, Fleming I. Soluble epoxide hydrolase regulates hematopoietic progenitor cell function via generation of fatty acid diols. Proceedings of the National Academy of Sciences of the United States of America. 109: 9995-10000. PMID 22665795 DOI: 10.1073/Pnas.1206493109  0.325
2012 Sanders WG, Morisseau C, Hammock BD, Cheung AK, Terry CM. Soluble epoxide hydrolase expression in a porcine model of arteriovenous graft stenosis and anti-inflammatory effects of a soluble epoxide hydrolase inhibitor. American Journal of Physiology. Cell Physiology. 303: C278-90. PMID 22621785 DOI: 10.1152/Ajpcell.00386.2011  0.32
2012 Zhang W, Yang AL, Liao J, Li H, Dong H, Chung YT, Bai H, Matkowskyj KA, Hammock BD, Yang GY. Soluble epoxide hydrolase gene deficiency or inhibition attenuates chronic active inflammatory bowel disease in IL-10(-/-) mice. Digestive Diseases and Sciences. 57: 2580-91. PMID 22588244 DOI: 10.1007/S10620-012-2217-1  0.308
2012 Inceoglu AB, Clifton HL, Yang J, Hegedus C, Hammock BD, Schaefer S. Inhibition of soluble epoxide hydrolase limits niacin-induced vasodilation in mice. Journal of Cardiovascular Pharmacology. 60: 70-5. PMID 22526297 DOI: 10.1097/Fjc.0B013E3182580A5D  0.802
2012 Lundström SL, Yang J, Källberg HJ, Thunberg S, Gafvelin G, Haeggström JZ, Grönneberg R, Grunewald J, van Hage M, Hammock BD, Eklund A, Wheelock ÅM, Wheelock CE. Allergic asthmatics show divergent lipid mediator profiles from healthy controls both at baseline and following birch pollen provocation. Plos One. 7: e33780. PMID 22438998 DOI: 10.1371/Journal.Pone.0033780  0.531
2012 Morisseau C, Schebb NH, Dong H, Ulu A, Aronov PA, Hammock BD. Role of soluble epoxide hydrolase phosphatase activity in the metabolism of lysophosphatidic acids. Biochemical and Biophysical Research Communications. 419: 796-800. PMID 22387545 DOI: 10.1016/J.Bbrc.2012.02.108  0.668
2012 Zhang D, Xie X, Chen Y, Hammock BD, Kong W, Zhu Y. Homocysteine upregulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo Circulation Research. 110: 808-817. PMID 22354938 DOI: 10.1161/Circresaha.111.259325  0.32
2012 Neckár J, Kopkan L, Husková Z, Kolář F, Papoušek F, Kramer HJ, Hwang SH, Hammock BD, Imig JD, Malý J, Netuka I, Ošťádal B, Červenka L. Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-I-ylureido)cyclohexyloxy] benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension Clinical Science. 122: 513-525. PMID 22324471 DOI: 10.1042/Cs20110622  0.342
2012 Shen HC, Hammock BD. Discovery of inhibitors of soluble epoxide hydrolase: a target with multiple potential therapeutic indications. Journal of Medicinal Chemistry. 55: 1789-808. PMID 22168898 DOI: 10.1021/Jm201468J  0.416
2012 Pecic S, Deng SX, Morisseau C, Hammock BD, Landry DW. Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase Bioorganic and Medicinal Chemistry Letters. 22: 601-605. PMID 22079754 DOI: 10.1016/J.Bmcl.2011.10.074  0.339
2012 Ahn KC, Kasagami T, Tsai HJ, Schebb NH, Ogunyoku T, Gee SJ, Young TM, Hammock BD. An immunoassay to evaluate human/environmental exposure to the antimicrobial triclocarban. Environmental Science & Technology. 46: 374-81. PMID 22077920 DOI: 10.1021/Es202494D  0.556
2012 Iyer A, Kauter K, Alam MA, Hwang SH, Morisseau C, Hammock BD, Brown L. Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats. Experimental Diabetes Research. 2012: 758614. PMID 22007192 DOI: 10.1155/2012/758614  0.301
2012 Schebb NH, Franze B, Maul R, Ranganathan A, Hammock BD. In vitro glucuronidation of the antibacterial triclocarban and its oxidative metabolites Drug Metabolism and Disposition. 40: 25-31. PMID 21953915 DOI: 10.1124/Dmd.111.042283  0.31
2012 Ulu A, Appt S, Morisseau C, Hwang SH, Jones PD, Rose TE, Dong H, Lango J, Yang J, Tsai HJ, Miyabe C, Fortenbach C, Adams MR, Hammock BD. Pharmacokinetics and in vivo potency of soluble epoxide hydrolase inhibitors in cynomolgus monkeys. British Journal of Pharmacology. 165: 1401-12. PMID 21880036 DOI: 10.1111/J.1476-5381.2011.01641.X  0.724
2012 Huang SX, Cao B, Morisseau C, Jin Y, Hammock BD, Long YQ. Structure-based optimization of the piperazino-containing 1,3 -disubstituted ureas affording sub-nanomolar inhibitors of soluble epoxide hydrolase Medchemcomm. 3: 379-384. DOI: 10.1039/C2Md00288D  0.305
2011 Kamita SG, Samra AI, Liu JY, Cornel AJ, Hammock BD. Juvenile hormone (JH) esterase of the mosquito Culex quinquefasciatus is not a target of the JH analog insecticide methoprene Plos One. 6. PMID 22174797 DOI: 10.1371/Journal.Pone.0028392  0.374
2011 Lundström SL, Levänen B, Nording M, Klepczynska-Nyström A, Sköld M, Haeggström JZ, Grunewald J, Svartengren M, Hammock BD, Larsson BM, Eklund A, Wheelock ÅM, Wheelock CE. Asthmatics exhibit altered oxylipin profiles compared to healthy individuals after subway air exposure. Plos One. 6: e23864. PMID 21897859 DOI: 10.1371/Journal.Pone.0023864  0.524
2011 Inoue H, Hwang SH, Wecksler AT, Hammock BD, Weiss RH. Sorafenib attenuates p21 in kidney cancer cells and augments cell death in combination with DNA-damaging chemotherapy. Cancer Biology & Therapy. 12: 827-36. PMID 21878748 DOI: 10.4161/Cbt.12.9.17680  0.306
2011 Wagner K, Inceoglu B, Hammock BD. Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception Prostaglandins and Other Lipid Mediators. 96: 76-83. PMID 21854866 DOI: 10.1016/J.Prostaglandins.2011.08.001  0.646
2011 Liu JY, Qiu H, Morisseau C, Hwang SH, Tsai HJ, Ulu A, Chiamvimonvat N, Hammock BD. Inhibition of soluble epoxide hydrolase contributes to the anti-inflammatory effect of antimicrobial triclocarban in a murine model. Toxicology and Applied Pharmacology. 255: 200-6. PMID 21741984 DOI: 10.1016/J.Taap.2011.06.017  0.713
2011 Davis BB, Liu JY, Tancredi DJ, Wang L, Simon SI, Hammock BD, Pinkerton KE. The anti-inflammatory effects of soluble epoxide hydrolase inhibitors are independent of leukocyte recruitment. Biochemical and Biophysical Research Communications. 410: 494-500. PMID 21683067 DOI: 10.1016/J.Bbrc.2011.06.008  0.311
2011 Schebb NH, Inceoglu B, Rose T, Wagner K, Hammock BD. Development of an ultra fast online-solid phase extraction (SPE) liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS) based approach for the determination of drugs in pharmacokinetic studies. Analytical Methods : Advancing Methods and Applications. 3: 420-428. PMID 21660124 DOI: 10.1039/C0Ay00714E  0.559
2011 Luria A, Bettaieb A, Xi Y, Shieh GJ, Liu HC, Inoue H, Tsai HJ, Imig JD, Haj FG, Hammock BD. Soluble epoxide hydrolase deficiency alters pancreatic islet size and improves glucose homeostasis in a model of insulin resistance. Proceedings of the National Academy of Sciences of the United States of America. 108: 9038-43. PMID 21571638 DOI: 10.1073/Pnas.1103482108  0.526
2011 Schebb NH, Huby M, Morisseau C, Hwang SH, Hammock BD. Development of an online SPE-LC-MS-based assay using endogenous substrate for investigation of soluble epoxide hydrolase (sEH) inhibitors Analytical and Bioanalytical Chemistry. 400: 1359-1366. PMID 21479549 DOI: 10.1007/S00216-011-4861-2  0.328
2011 Hwang SH, Wagner KM, Morisseau C, Liu JY, Dong H, Wecksler AT, Hammock BD. Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase. Journal of Medicinal Chemistry. 54: 3037-50. PMID 21434686 DOI: 10.1021/Jm2001376  0.639
2011 Aboutabl ME, Zordoky BN, Hammock BD, El-Kadi AO. Inhibition of soluble epoxide hydrolase confers cardioprotection and prevents cardiac cytochrome P450 induction by benzo(a)pyrene. Journal of Cardiovascular Pharmacology. 57: 273-81. PMID 21383588 DOI: 10.1097/Fjc.0B013E3182055Baf  0.322
2011 Inceoglu B, Wagner K, Schebb NH, Morisseau C, Jinks SL, Ulu A, Hegedus C, Rose T, Brosnan R, Hammock BD. Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP. Proceedings of the National Academy of Sciences of the United States of America. 108: 5093-7. PMID 21383170 DOI: 10.1073/Pnas.1101073108  0.743
2011 Schebb NH, Inceoglu B, Ahn KC, Morisseau C, Gee SJ, Hammock BD. Investigation of human exposure to triclocarban after showering and preliminary evaluation of its biological effects. Environmental Science & Technology. 45: 3109-15. PMID 21381656 DOI: 10.1021/Es103650M  0.34
2011 Morisseau C, Bernay M, Escaich A, Sanborn JR, Lango J, Hammock BD. Development of fluorescent substrates for microsomal epoxide hydrolase and application to inhibition studies. Analytical Biochemistry. 414: 154-62. PMID 21371418 DOI: 10.1016/J.Ab.2011.02.038  0.353
2011 Kim IH, Park YK, Hammock BD, Nishi K. Structure-activity relationships of cycloalkylamide derivatives as inhibitors of the soluble epoxide hydrolase. Journal of Medicinal Chemistry. 54: 1752-61. PMID 21338111 DOI: 10.1021/Jm101431V  0.338
2011 Li N, Liu JY, Qiu H, Harris TR, Sirish P, Hammock BD, Chiamvimonvat N. Use of metabolomic profiling in the study of arachidonic acid metabolism in cardiovascular disease. Congestive Heart Failure (Greenwich, Conn.). 17: 42-6. PMID 21272227 DOI: 10.1111/J.1751-7133.2010.00209.X  0.331
2011 Koeners MP, Wesseling S, Ulu A, Sepúlveda RL, Morisseau C, Braam B, Hammock BD, Joles JA. Soluble epoxide hydrolase in the generation and maintenance of high blood pressure in spontaneously hypertensive rats. American Journal of Physiology. Endocrinology and Metabolism. 300: E691-8. PMID 21266668 DOI: 10.1152/Ajpendo.00710.2010  0.624
2011 Honetschlägerová Z, Z Husková Z, Vaňourková Z, Sporková A, Kramer HJ, Hwang SH, Tsai HJ, Hammock BD, Imig JD, Červenka L, Kopkan L. Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats with inducible hypertension. The Journal of Physiology. 589: 207-19. PMID 21078594 DOI: 10.1113/Jphysiol.2010.199505  0.538
2011 Wagner K, Inceoglu B, Gill SS, Hammock BD. Epoxygenated fatty acids and soluble epoxide hydrolase inhibition: novel mediators of pain reduction. Journal of Agricultural and Food Chemistry. 59: 2816-24. PMID 20958046 DOI: 10.1021/Jf102559Q  0.647
2011 Qiu H, Li N, Liu JY, Harris TR, Hammock BD, Chiamvimonvat N. Soluble epoxide hydrolase inhibitors and heart failure. Cardiovascular Therapeutics. 29: 99-111. PMID 20433684 DOI: 10.1111/J.1755-5922.2010.00150.X  0.306
2010 Huang SX, Li HY, Liu JY, Morisseau C, Hammock BD, Long YQ. Incorporation of piperazino functionality into 1,3-disubstituted urea as the tertiary pharmacophore affording potent inhibitors of soluble epoxide hydrolase with improved pharmacokinetic properties. Journal of Medicinal Chemistry. 53: 8376-86. PMID 21070033 DOI: 10.1021/Jm101087U  0.341
2010 Liu JY, Li N, Yang J, Li N, Qiu H, Ai D, Chiamvimonvat N, Zhu Y, Hammock BD. Metabolic profiling of murine plasma reveals an unexpected biomarker in rofecoxib-mediated cardiovascular events. Proceedings of the National Academy of Sciences of the United States of America. 107: 17017-22. PMID 20837537 DOI: 10.1073/Pnas.1011278107  0.331
2010 Rose TE, Morisseau C, Liu JY, Inceoglu B, Jones PD, Sanborn JR, Hammock BD. 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain. Journal of Medicinal Chemistry. 53: 7067-75. PMID 20812725 DOI: 10.1021/Jm100691C  0.354
2010 Jung O, Jansen F, Mieth A, Barbosa-Sicard E, Pliquett RU, Babelova A, Morisseau C, Hwang SH, Tsai C, Hammock BD, Schaefer L, Geisslinger G, Amann K, Brandes RP. Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease. Plos One. 5: e11979. PMID 20694143 DOI: 10.1371/Journal.Pone.0011979  0.355
2010 Rayo J, Muñoz L, Rosell G, Hammock BD, Guerrero A, Luque FJ, Pouplana R. Reactivity versus steric effects in fluorinated ketones as esterase inhibitors: a quantum mechanical and molecular dynamics study. Journal of Molecular Modeling. 16: 1753-64. PMID 20676708 DOI: 10.1007/S00894-010-0807-4  0.329
2010 Morisseau C, Inceoglu B, Schmelzer K, Tsai HJ, Jinks SL, Hegedus CM, Hammock BD. Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids. Journal of Lipid Research. 51: 3481-90. PMID 20664072 DOI: 10.1194/Jlr.M006007  0.56
2010 Wang YX, Ulu A, Zhang LN, Hammock B. Soluble epoxide hydrolase in atherosclerosis. Current Atherosclerosis Reports. 12: 174-83. PMID 20425256 DOI: 10.1007/S11883-010-0108-5  0.645
2010 Tsai HJ, Hwang SH, Morisseau C, Yang J, Jones PD, Kasagami T, Kim IH, Hammock BD. Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 40: 222-38. PMID 20359531 DOI: 10.1016/J.Ejps.2010.03.018  0.587
2010 Kamita SG, Wogulis MD, Law CS, Morisseau C, Tanaka H, Huang H, Wilson DK, Hammock BD. Function of phenylalanine 259 and threonine 314 within the substrate binding pocket of the juvenile hormone esterase of Manduca sexta. Biochemistry. 49: 3733-42. PMID 20307057 DOI: 10.1021/Bi901641X  0.327
2010 Revermann M, Schloss M, Barbosa-Sicard E, Mieth A, Liebner S, Morisseau C, Geisslinger G, Schermuly RT, Fleming I, Hammock BD, Brandes RP. Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 909-14. PMID 20224052 DOI: 10.1161/Atvbaha.110.204099  0.318
2010 Kubala L, Schmelzer KR, Klinke A, Kolarova H, Baldus S, Hammock BD, Eiserich JP. Modulation of arachidonic and linoleic acid metabolites in myeloperoxidase-deficient mice during acute inflammation. Free Radical Biology & Medicine. 48: 1311-20. PMID 20156554 DOI: 10.1016/J.Freeradbiomed.2010.02.010  0.322
2010 Certíková Chábová V, Walkowska A, Kompanowska-Jezierska E, Sadowski J, Kujal P, Vernerová Z, Vanourková Z, Kopkan L, Kramer HJ, Falck JR, Imig JD, Hammock BD, Vanecková I, Cervenka L. Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats. Clinical Science (London, England : 1979). 118: 617-32. PMID 20050826 DOI: 10.1042/Cs20090459  0.314
2010 Simpkins AN, Rudic RD, Roy S, Tsai HJ, Hammock BD, Imig JD. Soluble epoxide hydrolase inhibition modulates vascular remodeling. American Journal of Physiology. Heart and Circulatory Physiology. 298: H795-806. PMID 20035028 DOI: 10.1152/Ajpheart.00543.2009  0.561
2010 Liu JY, Yang J, Inceoglu B, Qiu H, Ulu A, Hwang SH, Chiamvimonvat N, Hammock BD. Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model. Biochemical Pharmacology. 79: 880-7. PMID 19896470 DOI: 10.1016/J.Bcp.2009.10.025  0.666
2010 Chaudhary KR, Abukhashim M, Hwang SH, Hammock BD, Seubert JM. Inhibition of soluble epoxide hydrolase by trans-4- [4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is protective against ischemia-reperfusion injury. Journal of Cardiovascular Pharmacology. 55: 67-73. PMID 19834332 DOI: 10.1097/Fjc.0B013E3181C37D69  0.314
2010 Liao J, Norwood SD, Chung YT, Li H, Hammock BD, Yang G. Abstract 5702: Soluble epoxide hydrolase: unique biomarker and chemopreventive target of chronic colitis-induced carcinogenesis Cancer Research. 70: 5702-5702. DOI: 10.1158/1538-7445.Am10-5702  0.321
2010 BORHAN B, NOUROOZ-ZADEH J, UEMATSU T, HAMMOCK BD, KURTH MJ. ChemInform Abstract: Stereochemical Aspects of Cytosolic Epoxide Hydrolase Hydration of Methyl Diepoxystearates. Cheminform. 24: no-no. DOI: 10.1002/chin.199329058  0.36
2009 Ahn KC, Gee SJ, Tsai HJ, Bennett D, Nishioka MG, Blum A, Fishman E, Hammock BD. Immunoassay for monitoring environmental and human exposure to the polybrominated diphenyl ether BDE-47. Environmental Science & Technology. 43: 7784-90. PMID 19921894 DOI: 10.1021/Es9009037  0.555
2009 Imig JD, Hammock BD. Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases. Nature Reviews. Drug Discovery. 8: 794-805. PMID 19794443 DOI: 10.1038/Nrd2875  0.335
2009 Chawengsub Y, Gauthier KM, Nithipatikom K, Hammock BD, Falck JR, Narsimhaswamy D, Campbell WB. Identification of 13-hydroxy-14,15-epoxyeicosatrienoic acid as an acid-stable endothelium-derived hyperpolarizing factor in rabbit arteries. The Journal of Biological Chemistry. 284: 31280-90. PMID 19737933 DOI: 10.1074/Jbc.M109.025627  0.306
2009 Li N, Liu JY, Timofeyev V, Qiu H, Hwang SH, Tuteja D, Lu L, Yang J, Mochida H, Low R, Hammock BD, Chiamvimonvat N. Beneficial effects of soluble epoxide hydrolase inhibitors in myocardial infarction model: Insight gained using metabolomic approaches. Journal of Molecular and Cellular Cardiology. 47: 835-45. PMID 19716829 DOI: 10.1016/J.Yjmcc.2009.08.017  0.306
2009 Barbosa-Sicard E, Frömel T, Keserü B, Brandes RP, Morisseau C, Hammock BD, Braun T, Krüger M, Fleming I. Inhibition of the soluble epoxide hydrolase by tyrosine nitration. The Journal of Biological Chemistry. 284: 28156-63. PMID 19704161 DOI: 10.1074/Jbc.M109.054759  0.368
2009 Liu JY, Park SH, Morisseau C, Hwang SH, Hammock BD, Weiss RH. Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo. Molecular Cancer Therapeutics. 8: 2193-203. PMID 19671760 DOI: 10.1158/1535-7163.Mct-09-0119  0.351
2009 Falck JR, Kodela R, Manne R, Atcha KR, Puli N, Dubasi N, Manthati VL, Capdevila JH, Yi XY, Goldman DH, Morisseau C, Hammock BD, Campbell WB. 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition. Journal of Medicinal Chemistry. 52: 5069-75. PMID 19653681 DOI: 10.1021/Jm900634W  0.35
2009 Matveeva EG, Morisseau C, Goodrow MH, Mullin C, Hammock BD. Tryptophan fluorescence quenching by enzyme inhibitors as a tool for enzyme active site structure investigation: epoxide hydrolase. Current Pharmaceutical Biotechnology. 10: 589-99. PMID 19619123 DOI: 10.2174/138920109789069260  0.33
2009 Luria A, Morisseau C, Tsai HJ, Yang J, Inceoglu B, De Taeye B, Watkins SM, Wiest MM, German JB, Hammock BD. Alteration in plasma testosterone levels in male mice lacking soluble epoxide hydrolase. American Journal of Physiology. Endocrinology and Metabolism. 297: E375-83. PMID 19458064 DOI: 10.1152/Ajpendo.00131.2009  0.575
2009 Simpkins AN, Rudic RD, Schreihofer DA, Roy S, Manhiani M, Tsai HJ, Hammock BD, Imig JD. Soluble epoxide inhibition is protective against cerebral ischemia via vascular and neural protection. The American Journal of Pathology. 174: 2086-95. PMID 19435785 DOI: 10.2353/Ajpath.2009.080544  0.542
2009 Xie Y, Liu Y, Gong G, Smith DH, Yan F, Rinderspacher A, Feng Y, Zhu Z, Li X, Deng SX, Branden L, Vidović D, Chung C, Schürer S, Morisseau C, ... Hammock BD, et al. Discovery of potent non-urea inhibitors of soluble epoxide hydrolase. Bioorganic & Medicinal Chemistry Letters. 19: 2354-9. PMID 19303288 DOI: 10.1016/J.Bmcl.2008.09.066  0.303
2009 Revermann M, Barbosa-Sicard E, Dony E, Schermuly RT, Morisseau C, Geisslinger G, Fleming I, Hammock BD, Brandes RP. Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats. Journal of Hypertension. 27: 322-31. PMID 19226702 DOI: 10.1097/Hjh.0B013E32831Aedfa  0.304
2009 Kasagami T, Kim IH, Tsai HJ, Nishi K, Hammock BD, Morisseau C. Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities. Bioorganic & Medicinal Chemistry Letters. 19: 1784-9. PMID 19216074 DOI: 10.1016/J.Bmcl.2009.01.069  0.588
2009 Inceoglu AB, Waite TD, Christiansen JA, McAbee RD, Kamita SG, Hammock BD, Cornel AJ. A rapid luminescent assay for measuring cytochrome P450 activity in individual larval Culex pipiens complex mosquitoes (Diptera: Culicidae). Journal of Medical Entomology. 46: 83-92. PMID 19198521 DOI: 10.1603/033.046.0111  0.775
2009 Liu JY, Tsai HJ, Hwang SH, Jones PD, Morisseau C, Hammock BD. Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation. British Journal of Pharmacology. 156: 284-96. PMID 19154430 DOI: 10.1111/J.1476-5381.2008.00009.X  0.565
2009 Kim HJ, Ahn KC, González-Techera A, González-Sapienza GG, Gee SJ, Hammock BD. Magnetic bead-based phage anti-immunocomplex assay (PHAIA) for the detection of the urinary biomarker 3-phenoxybenzoic acid to assess human exposure to pyrethroid insecticides. Analytical Biochemistry. 386: 45-52. PMID 19101498 DOI: 10.1016/J.Ab.2008.12.003  0.302
2009 Rawal S, Morisseau C, Hammock BD, Shivachar AC. Differential subcellular distribution and colocalization of the microsomal and soluble epoxide hydrolases in cultured neonatal rat brain cortical astrocytes. Journal of Neuroscience Research. 87: 218-27. PMID 18711743 DOI: 10.1002/Jnr.21827  0.309
2009 Olearczyk JJ, Quigley JE, Mitchell BC, Yamamoto T, Kim IH, Newman JW, Luria A, Hammock BD, Imig JD. Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki rats. Clinical Science (London, England : 1979). 116: 61-70. PMID 18459944 DOI: 10.1042/Cs20080039  0.527
2009 Parrish AR, Chen G, Burghardt RC, Watanabe T, Morisseau C, Hammock BD. Attenuation of cisplatin nephrotoxicity by inhibition of soluble epoxide hydrolase. Cell Biology and Toxicology. 25: 217-25. PMID 18386137 DOI: 10.1007/S10565-008-9071-0  0.33
2008 Inceoglu B, Jinks SL, Ulu A, Hegedus CM, Georgi K, Schmelzer KR, Wagner K, Jones PD, Morisseau C, Hammock BD. Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways. Proceedings of the National Academy of Sciences of the United States of America. 105: 18901-6. PMID 19028872 DOI: 10.1073/Pnas.0809765105  0.759
2008 EnayetAllah AE, Luria A, Luo B, Tsai HJ, Sura P, Hammock BD, Grant DF. Opposite regulation of cholesterol levels by the phosphatase and hydrolase domains of soluble epoxide hydrolase. The Journal of Biological Chemistry. 283: 36592-8. PMID 18974052 DOI: 10.1074/Jbc.M806315200  0.539
2008 Fife KL, Liu Y, Schmelzer KR, Tsai HJ, Kim IH, Morisseau C, Hammock BD, Kroetz DL. Inhibition of soluble epoxide hydrolase does not protect against endotoxin-mediated hepatic inflammation. The Journal of Pharmacology and Experimental Therapeutics. 327: 707-15. PMID 18815352 DOI: 10.1124/Jpet.108.142398  0.562
2008 Ahn KC, Zhao B, Chen J, Cherednichenko G, Sanmarti E, Denison MS, Lasley B, Pessah IN, Kültz D, Chang DP, Gee SJ, Hammock BD. In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: receptor-based bioassay screens. Environmental Health Perspectives. 116: 1203-10. PMID 18795164 DOI: 10.1289/Ehp.11200  0.301
2008 Ulu A, Davis BB, Tsai HJ, Kim IH, Morisseau C, Inceoglu B, Fiehn O, Hammock BD, Weiss RH. Soluble epoxide hydrolase inhibitors reduce the development of atherosclerosis in apolipoprotein e-knockout mouse model. Journal of Cardiovascular Pharmacology. 52: 314-23. PMID 18791465 DOI: 10.1097/Fjc.0B013E318185Fa3C  0.723
2008 Athirakul K, Bradbury JA, Graves JP, DeGraff LM, Ma J, Zhao Y, Couse JF, Quigley R, Harder DR, Zhao X, Imig JD, Pedersen TL, Newman JW, Hammock BD, Conley AJ, et al. Increased blood pressure in mice lacking cytochrome P450 2J5. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 4096-108. PMID 18716027 DOI: 10.1096/Fj.08-114413  0.543
2008 Biswal BK, Morisseau C, Garen G, Cherney MM, Garen C, Niu C, Hammock BD, James MN. The molecular structure of epoxide hydrolase B from Mycobacterium tuberculosis and its complex with a urea-based inhibitor. Journal of Molecular Biology. 381: 897-912. PMID 18585390 DOI: 10.1016/J.Jmb.2008.06.030  0.303
2008 Harris TR, Aronov PA, Hammock BD. Soluble epoxide hydrolase homologs in Strongylocentrotus purpuratus suggest a gene duplication event and subsequent divergence. Dna and Cell Biology. 27: 467-77. PMID 18554159 DOI: 10.1089/Dna.2008.0751  0.328
2008 Jiang H, Zhu AG, Mamczur M, Morisseau C, Hammock BD, Falck JR, McGiff JC. Hydrolysis of cis- and trans-epoxyeicosatrienoic acids by rat red blood cells. The Journal of Pharmacology and Experimental Therapeutics. 326: 330-7. PMID 18445784 DOI: 10.1124/Jpet.107.134858  0.31
2008 Gross GJ, Gauthier KM, Moore J, Falck JR, Hammock BD, Campbell WB, Nithipatikom K. Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart. American Journal of Physiology. Heart and Circulatory Physiology. 294: H2838-44. PMID 18441205 DOI: 10.1152/Ajpheart.00186.2008  0.315
2008 Wheelock CE, Phillips BM, Anderson BS, Miller JL, Miller MJ, Hammock BD. Applications of carboxylesterase activity in environmental monitoring and toxicity identification evaluations (TIEs). Reviews of Environmental Contamination and Toxicology. 195: 117-78. PMID 18418956 DOI: 10.1007/978-0-387-77030-7_5  0.57
2008 Kim HJ, González-Techera A, González-Sapienza GG, Ahn KC, Gee SJ, Hammock BD. Phage-borne peptidomimetics accelerate the development of polyclonal antibody-based heterologous immunoassays for the detection of pesticide metabolites. Environmental Science & Technology. 42: 2047-53. PMID 18409635 DOI: 10.1021/Es702219A  0.331
2008 Morisseau C, Hammock BD. Gerry Brooks and epoxide hydrolases: four decades to a pharmaceutical. Pest Management Science. 64: 594-609. PMID 18383502 DOI: 10.1002/Ps.1583  0.386
2008 Morisseau C, Newman JW, Wheelock CE, Hill Iii T, Morin D, Buckpitt AR, Hammock BD. Development of metabolically stable inhibitors of Mammalian microsomal epoxide hydrolase. Chemical Research in Toxicology. 21: 951-7. PMID 18363382 DOI: 10.1021/Tx700446U  0.692
2008 Wheelock CE, Colvin ME, Sanborn JR, Hammock BD. Substituted 3-phenylpropenoates and related analogs: electron ionization mass spectral fragmentation and density functional theory calculations. Journal of Mass Spectrometry : Jms. 43: 1053-62. PMID 18286670 DOI: 10.1002/Jms.1384  0.497
2008 Harris TR, Aronov PA, Jones PD, Tanaka H, Arand M, Hammock BD. Identification of two epoxide hydrolases in Caenorhabditis elegans that metabolize mammalian lipid signaling molecules. Archives of Biochemistry and Biophysics. 472: 139-49. PMID 18267101 DOI: 10.1016/J.Abb.2008.01.016  0.364
2008 Wheelock CE, Forshed J, Goto S, Hammock BD, Newman JW. Effects of pyridine exposure upon structural lipid metabolism in Swiss Webster mice. Chemical Research in Toxicology. 21: 583-90. PMID 18251509 DOI: 10.1021/Tx7002454  0.663
2008 Dreisbach AW, Rice JC, Japa S, Newman JW, Sigel A, Gill RS, Hess AE, Cemo AC, Fonseca JP, Hammock BD, Lertora JJL, Hamm LL. Salt loading increases urinary excretion of linoleic acid diols and triols in healthy human subjects Hypertension. 51: 755-761. PMID 18227407 DOI: 10.1161/Hypertensionaha.107.100123  0.526
2008 Chawengsub Y, Aggarwal NT, Nithipatikom K, Gauthier KM, Anjaiah S, Hammock BD, Falck JR, Campbell WB. Identification of 15-hydroxy-11,12-epoxyeicosatrienoic acid as a vasoactive 15-lipoxygenase metabolite in rabbit aorta. American Journal of Physiology. Heart and Circulatory Physiology. 294: H1348-56. PMID 18192225 DOI: 10.1152/Ajpheart.01326.2007  0.311
2008 Wheelock CE, Nishi K, Ying A, Jones PD, Colvin ME, Olmstead MM, Hammock BD. Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). Bioorganic & Medicinal Chemistry. 16: 2114-30. PMID 18023188 DOI: 10.1016/J.Bmc.2007.10.081  0.565
2007 Wheelock CE, Goto S, Hammock BD, Newman JW. Clofibrate-induced changes in the liver, heart, brain and white adipose lipid metabolome of Swiss-Webster mice. Metabolomics : Official Journal of the Metabolomic Society. 3: 137-145. PMID 19079556 DOI: 10.1007/S11306-007-0052-8  0.661
2007 Ahn KC, Lohstroh P, Gee SJ, Gee NA, Lasley B, Hammock BD. High-throughput automated luminescent magnetic particle-based immunoassay to monitor human exposure to pyrethroid insecticides. Analytical Chemistry. 79: 8883-90. PMID 17983205 DOI: 10.1021/Ac070675L  0.301
2007 Kim IH, Tsai HJ, Nishi K, Kasagami T, Morisseau C, Hammock BD. 1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic properties. Journal of Medicinal Chemistry. 50: 5217-26. PMID 17894481 DOI: 10.1021/Jm070705C  0.565
2007 Hillard CJ, Ho WS, Thompson J, Gauthier KM, Wheelock CE, Huang H, Hammock BD. Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619. British Journal of Pharmacology. 152: 691-8. PMID 17891162 DOI: 10.1038/Sj.Bjp.0707468  0.525
2007 Chiamvimonvat N, Ho CM, Tsai HJ, Hammock BD. The soluble epoxide hydrolase as a pharmaceutical target for hypertension. Journal of Cardiovascular Pharmacology. 50: 225-37. PMID 17878749 DOI: 10.1097/Fjc.0B013E3181506445  0.595
2007 Vogel CF, Li W, Sciullo E, Newman J, Hammock B, Reader JR, Tuscano J, Matsumura F. Pathogenesis of aryl hydrocarbon receptor-mediated development of lymphoma is associated with increased cyclooxygenase-2 expression. The American Journal of Pathology. 171: 1538-48. PMID 17823287 DOI: 10.2353/Ajpath.2007.070406  0.52
2007 Hwang SH, Tsai HJ, Liu JY, Morisseau C, Hammock BD. Orally bioavailable potent soluble epoxide hydrolase inhibitors. Journal of Medicinal Chemistry. 50: 3825-40. PMID 17616115 DOI: 10.1021/Jm070270T  0.584
2007 Newman JW, Kaysen GA, Hammock BD, Shearer GC. Proteinuria increases oxylipid concentrations in VLDL and HDL but not LDL particles in the rat. Journal of Lipid Research. 48: 1792-800. PMID 17496268 DOI: 10.1194/Jlr.M700146-Jlr200  0.517
2007 Chen J, Ahn KC, Gee NA, Gee SJ, Hammock BD, Lasley BL. Antiandrogenic properties of parabens and other phenolic containing small molecules in personal care products. Toxicology and Applied Pharmacology. 221: 278-84. PMID 17481686 DOI: 10.1016/J.Taap.2007.03.015  0.334
2007 Kim HJ, Ahn KC, Ma SJ, Gee SJ, Hammock BD. Development of sensitive immunoassays for the detection of the glucuronide conjugate of 3-phenoxybenzyl alcohol, a putative human urinary biomarker for pyrethroid exposure. Journal of Agricultural and Food Chemistry. 55: 3750-7. PMID 17455946 DOI: 10.1021/Jf063282G  0.317
2007 Endsley MP, Aggarwal N, Isbell MA, Wheelock CE, Hammock BD, Falck JR, Campbell WB, Nithipatikom K. Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism. International Journal of Cancer. Journal International Du Cancer. 121: 984-91. PMID 17443494 DOI: 10.1002/Ijc.22761  0.516
2007 Zhang W, Koerner IP, Noppens R, Grafe M, Tsai HJ, Morisseau C, Luria A, Hammock BD, Falck JR, Alkayed NJ. Soluble epoxide hydrolase: a novel therapeutic target in stroke. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 27: 1931-40. PMID 17440491 DOI: 10.1038/Sj.Jcbfm.9600494  0.551
2007 Thompson DA, Hammock BD. Dihydroxyoctadecamonoenoate esters inhibit the neutrophil respiratory burst Journal of Biosciences. 32: 279-291. PMID 17435320 DOI: 10.1007/S12038-007-0028-X  0.31
2007 Huang H, Nishi K, Tsai HJ, Hammock BD. Development of highly sensitive fluorescent assays for fatty acid amide hydrolase. Analytical Biochemistry. 363: 12-21. PMID 17291440 DOI: 10.1016/J.Ab.2006.10.041  0.557
2007 Wadkins RM, Hyatt JL, Edwards CC, Tsurkan L, Redinbo MR, Wheelock CE, Jones PD, Hammock BD, Potter PM. Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds. Molecular Pharmacology. 71: 713-23. PMID 17167034 DOI: 10.1124/Mol.105.021683  0.581
2007 Inceoglu B, Schmelzer KR, Morisseau C, Jinks SL, Hammock BD. Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs). Prostaglandins & Other Lipid Mediators. 82: 42-9. PMID 17164131 DOI: 10.1016/J.Prostaglandins.2006.05.004  0.331
2007 Luria A, Weldon SM, Kabcenell AK, Ingraham RH, Matera D, Jiang H, Gill R, Morisseau C, Newman JW, Hammock BD. Compensatory mechanism for homeostatic blood pressure regulation in Ephx2 gene-disrupted mice. The Journal of Biological Chemistry. 282: 2891-8. PMID 17135253 DOI: 10.1074/Jbc.M608057200  0.566
2007 Kim IH, Nishi K, Tsai HJ, Bradford T, Koda Y, Watanabe T, Morisseau C, Blanchfield J, Toth I, Hammock BD. Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase. Bioorganic & Medicinal Chemistry. 15: 312-23. PMID 17046265 DOI: 10.1016/J.Bmc.2006.09.057  0.598
2007 Dreisbach AW, Japa S, Newman JW, Sigel A, Gill RS, Hess AE, Hammock BD, Lertora JJL. 356 Salt Loading Increases The Urinary Excretion Of Linoleic Diols And Triols In Healthy Human Subjects. Journal of Investigative Medicine. 55. DOI: 10.1097/00042871-200701010-00870  0.522
2006 Xu D, Li N, He Y, Timofeyev V, Lu L, Tsai HJ, Kim IH, Tuteja D, Mateo RK, Singapuri A, Davis BB, Low R, Hammock BD, Chiamvimonvat N. Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 103: 18733-8. PMID 17130447 DOI: 10.1073/Pnas.0609158103  0.532
2006 Inceoglu AB, Kamita SG, Hammock BD. Genetically modified baculoviruses: a historical overview and future outlook. Advances in Virus Research. 68: 323-60. PMID 16997016 DOI: 10.1016/S0065-3527(06)68009-3  0.764
2006 Inceoglu B, Jinks SL, Schmelzer KR, Waite T, Kim IH, Hammock BD. Inhibition of soluble epoxide hydrolase reduces LPS-induced thermal hyperalgesia and mechanical allodynia in a rat model of inflammatory pain. Life Sciences. 79: 2311-9. PMID 16962614 DOI: 10.1016/J.Lfs.2006.07.031  0.38
2006 Schmelzer KR, Inceoglu B, Kubala L, Kim IH, Jinks SL, Eiserich JP, Hammock BD. Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 103: 13646-51. PMID 16950874 DOI: 10.1073/Pnas.0605908103  0.332
2006 Hwang SH, Morisseau C, Do Z, Hammock BD. Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors. Bioorganic & Medicinal Chemistry Letters. 16: 5773-7. PMID 16949285 DOI: 10.1016/J.Bmcl.2006.08.078  0.313
2006 Morisseau C, Newman JW, Tsai HJ, Baecker PA, Hammock BD. Peptidyl-urea based inhibitors of soluble epoxide hydrolases. Bioorganic & Medicinal Chemistry Letters. 16: 5439-44. PMID 16908134 DOI: 10.1016/J.Bmcl.2006.07.073  0.677
2006 Jones PD, Tsai HJ, Do ZN, Morisseau C, Hammock BD. Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase. Bioorganic & Medicinal Chemistry Letters. 16: 5212-6. PMID 16870439 DOI: 10.1016/J.Bmcl.2006.07.009  0.557
2006 Seubert JM, Sinal CJ, Graves J, DeGraff LM, Bradbury JA, Lee CR, Goralski K, Carey MA, Luria A, Newman JW, Hammock BD, Falck JR, Roberts H, Rockman HA, Murphy E, et al. Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function. Circulation Research. 99: 442-50. PMID 16857962 DOI: 10.1161/01.Res.0000237390.92932.37  0.538
2006 Li HY, Jin Y, Morisseau C, Hammock BD, Long YQ. The 5-substituted piperazine as a novel secondary pharmacophore greatly improving the physical properties of urea-based inhibitors of soluble epoxide hydrolase. Bioorganic & Medicinal Chemistry. 14: 6586-92. PMID 16784862 DOI: 10.1016/J.Bmc.2006.06.005  0.325
2006 Olearczyk JJ, Field MB, Kim IH, Morisseau C, Hammock BD, Imig JD. Substituted adamantyl-urea inhibitors of the soluble epoxide hydrolase dilate mesenteric resistance vessels. The Journal of Pharmacology and Experimental Therapeutics. 318: 1307-14. PMID 16772540 DOI: 10.1124/Jpet.106.103556  0.341
2006 Wolf NM, Morisseau C, Jones PD, Hock B, Hammock BD. Development of a high-throughput screen for soluble epoxide hydrolase inhibition. Analytical Biochemistry. 355: 71-80. PMID 16729954 DOI: 10.1016/J.Ab.2006.04.045  0.348
2006 Wheelock CE, Miller JL, Miller MJ, Phillips BM, Huntley SA, Gee SJ, Tjeerdema RS, Hammock BD. Use of carboxylesterase activity to remove pyrethroid-associated toxicity to Ceriodaphnia dubia and Hyalella azteca in toxicity identification evaluations. Environmental Toxicology and Chemistry / Setac. 25: 973-84. PMID 16629136 DOI: 10.1897/05-334R.1  0.526
2006 Amin DN, Kamita SG, Muluvi GM, Machuka J, Hammock BD, Osir EO. Glossina proteolytic lectin does not require a carbohydrate moiety for enzymatic or trypanosome-transforming activities. Journal of Medical Entomology. 43: 301-8. PMID 16619615 DOI: 10.1603/0022-2585(2006)043[0301:Gpldnr]2.0.Co;2  0.317
2006 Lee CR, North KE, Bray MS, Fornage M, Seubert JM, Newman JW, Hammock BD, Couper DJ, Heiss G, Zeldin DC. Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study. Human Molecular Genetics. 15: 1640-9. PMID 16595607 DOI: 10.1093/Hmg/Ddl085  0.492
2006 Wogulis M, Wheelock CE, Kamita SG, Hinton AC, Whetstone PA, Hammock BD, Wilson DK. Structural studies of a potent insect maturation inhibitor bound to the juvenile hormone esterase of Manduca sexta. Biochemistry. 45: 4045-57. PMID 16566578 DOI: 10.1021/Bi0521644  0.754
2006 Harris TR, Morisseau C, Walzem RL, Ma SJ, Hammock BD. The cloning and characterization of a soluble epoxide hydrolase in chicken. Poultry Science. 85: 278-87. PMID 16523628 DOI: 10.1093/Ps/85.2.278  0.359
2006 Ahn KC, Ma SJ, Tsai HJ, Gee SJ, Hammock BD. An immunoassay for a urinary metabolite as a biomarker of human exposure to the pyrethroid insecticide permethrin. Analytical and Bioanalytical Chemistry. 384: 713-22. PMID 16416099 DOI: 10.1007/S00216-005-0220-5  0.556
2006 Rajendra W, Hackett KJ, Buckley E, Hammock BD. Functional expression of lepidopteran-selective neurotoxin in baculovirus: potential for effective pest management. Biochimica Et Biophysica Acta. 1760: 158-63. PMID 16406338 DOI: 10.1016/J.Bbagen.2005.11.008  0.319
2006 Nishi K, Huang H, Kamita SG, Kim IH, Morisseau C, Hammock BD. Characterization of pyrethroid hydrolysis by the human liver carboxylesterases hCE-1 and hCE-2. Archives of Biochemistry and Biophysics. 445: 115-23. PMID 16359636 DOI: 10.1016/J.Abb.2005.11.005  0.311
2006 Gomez GA, Morisseau C, Hammock BD, Christianson DW. Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids. Protein Science : a Publication of the Protein Society. 15: 58-64. PMID 16322563 DOI: 10.1110/Ps.051720206  0.316
2006 Larsen BT, Miura H, Hatoum OA, Campbell WB, Hammock BD, Zeldin DC, Falck JR, Gutterman DD. Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BK(Ca) channels: implications for soluble epoxide hydrolase inhibition. American Journal of Physiology. Heart and Circulatory Physiology. 290: H491-9. PMID 16258029 DOI: 10.1152/Ajpheart.00927.2005  0.312
2006 Davis BB, Morisseau C, Newman JW, Pedersen TL, Hammock BD, Weiss RH. Attenuation of vascular smooth muscle cell proliferation by 1-cyclohexyl-3-dodecyl urea is independent of soluble epoxide hydrolase inhibition. The Journal of Pharmacology and Experimental Therapeutics. 316: 815-21. PMID 16221742 DOI: 10.1124/Jpet.105.091876  0.582
2005 Dorrance AM, Rupp N, Pollock DM, Newman JW, Hammock BD, Imig JD. An epoxide hydrolase inhibitor, 12-(3-adamantan-1-yl-ureido)dodecanoic acid (AUDA), reduces ischemic cerebral infarct size in stroke-prone spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology. 46: 842-8. PMID 16306811 DOI: 10.1097/01.Fjc.0000189600.74157.6D  0.535
2005 Liu Y, Zhang Y, Schmelzer K, Lee TS, Fang X, Zhu Y, Spector AA, Gill S, Morisseau C, Hammock BD, Shyy JY. The antiinflammatory effect of laminar flow: the role of PPARgamma, epoxyeicosatrienoic acids, and soluble epoxide hydrolase. Proceedings of the National Academy of Sciences of the United States of America. 102: 16747-52. PMID 16267130 DOI: 10.1073/Pnas.0508081102  0.312
2005 Huang H, Fleming CD, Nishi K, Redinbo MR, Hammock BD. Stereoselective hydrolysis of pyrethroid-like fluorescent substrates by human and other mammalian liver carboxylesterases. Chemical Research in Toxicology. 18: 1371-7. PMID 16167828 DOI: 10.1021/Tx050072+  0.308
2005 Imig JD, Zhao X, Zaharis CZ, Olearczyk JJ, Pollock DM, Newman JW, Kim IH, Watanabe T, Hammock BD. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension. Hypertension. 46: 975-81. PMID 16157792 DOI: 10.1161/01.Hyp.0000176237.74820.75  0.525
2005 Tran KL, Aronov PA, Tanaka H, Newman JW, Hammock BD, Morisseau C. Lipid sulfates and sulfonates are allosteric competitive inhibitors of the N-terminal phosphatase activity of the mammalian soluble epoxide hydrolase. Biochemistry. 44: 12179-87. PMID 16142916 DOI: 10.1021/Bi050842G  0.583
2005 Kang KD, Jones PD, Huang H, Zhang R, Mostovich LA, Wheelock CE, Watanabe T, Gulyaeva LF, Hammock BD. Evaluation of alpha-cyano ethers as fluorescent substrates for assay of cytochrome P450 enzyme activity. Analytical Biochemistry. 344: 183-92. PMID 16083846 DOI: 10.1016/J.Ab.2005.06.032  0.539
2005 Wheelock CE, Eder KJ, Werner I, Huang H, Jones PD, Brammell BF, Elskus AA, Hammock BD. Individual variability in esterase activity and CYP1A levels in Chinook salmon (Oncorhynchus tshawytscha) exposed to esfenvalerate and chlorpyrifos. Aquatic Toxicology (Amsterdam, Netherlands). 74: 172-92. PMID 16011852 DOI: 10.1016/J.Aquatox.2005.05.009  0.546
2005 Schmelzer KR, Kubala L, Newman JW, Kim IH, Eiserich JP, Hammock BD. Soluble epoxide hydrolase is a therapeutic target for acute inflammation. Proceedings of the National Academy of Sciences of the United States of America. 102: 9772-7. PMID 15994227 DOI: 10.1073/Pnas.0503279102  0.544
2005 Jones PD, Wolf NM, Morisseau C, Whetstone P, Hock B, Hammock BD. Fluorescent substrates for soluble epoxide hydrolase and application to inhibition studies. Analytical Biochemistry. 343: 66-75. PMID 15963942 DOI: 10.1016/J.Ab.2005.03.041  0.341
2005 Wheelock CE, Miller JL, Miller MJ, Phillips BM, Gee SJ, Tjeerdema RS, Hammock BD. Influence of container adsorption upon observed pyrethroid toxicity to Ceriodaphnia dubia and Hyalella azteca. Aquatic Toxicology (Amsterdam, Netherlands). 74: 47-52. PMID 15951033 DOI: 10.1016/J.Aquatox.2005.04.007  0.494
2005 Nithipatikom K, Endsley MP, Isbell MA, Wheelock CE, Hammock BD, Campbell WB. A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells. Biochemical and Biophysical Research Communications. 332: 1028-33. PMID 15919052 DOI: 10.1016/J.Bbrc.2005.05.049  0.52
2005 Kim IH, Heirtzler FR, Morisseau C, Nishi K, Tsai HJ, Hammock BD. Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. Journal of Medicinal Chemistry. 48: 3621-9. PMID 15887969 DOI: 10.1021/Jm0500929  0.573
2005 Morisseau C, Hammock BD. Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles. Annual Review of Pharmacology and Toxicology. 45: 311-33. PMID 15822179 DOI: 10.1146/Annurev.Pharmtox.45.120403.095920  0.315
2005 Fang X, Hu S, Watanabe T, Weintraub NL, Snyder GD, Yao J, Liu Y, Shyy JY, Hammock BD, Spector AA. Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors. The Journal of Pharmacology and Experimental Therapeutics. 314: 260-70. PMID 15798002 DOI: 10.1124/Jpet.105.085605  0.369
2005 Shearer GC, Newman JW, Hammock BD, Kaysen GA. Graded effects of proteinuria on HDL structure in nephrotic rats. Journal of the American Society of Nephrology : Jasn. 16: 1309-19. PMID 15788471 DOI: 10.1681/Asn.2004080644  0.522
2005 Newman JW, Morisseau C, Hammock BD. Epoxide hydrolases: their roles and interactions with lipid metabolism. Progress in Lipid Research. 44: 1-51. PMID 15748653 DOI: 10.1016/J.Plipres.2004.10.001  0.554
2005 Koivunen ME, Gee SJ, Park EK, Lee K, Schenker MB, Hammock BD. Application of an enzyme-linked immunosorbent assay for the analysis of paraquat in human-exposure samples. Archives of Environmental Contamination and Toxicology. 48: 184-90. PMID 15696345 DOI: 10.1007/S00244-003-0251-X  0.553
2005 Sellers KW, Sun C, Diez-Freire C, Waki H, Morisseau C, Falck JR, Hammock BD, Paton JF, Raizada MK. Novel mechanism of brain soluble epoxide hydrolase-mediated blood pressure regulation in the spontaneously hypertensive rat. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 626-8. PMID 15659536 DOI: 10.1096/Fj.04-3128Fje  0.304
2005 TANIAI K, ZHOU CLE, LEE DG, MAEDA S, HAMMOCK BD. Expression of a Non-Secreted Form of Juvenile Hormone Esterase in a Baculovirus Japan Agricultural Research Quarterly: Jarq. 39: 11-18. DOI: 10.6090/Jarq.39.11  0.324
2004 Wheelock CE, Miller JL, Miller MJ, Gee SJ, Shan G, Hammock BD. Development of toxicity identification evaluation procedures for pyrethroid detection using esterase activity. Environmental Toxicology and Chemistry / Setac. 23: 2699-708. PMID 15559286 DOI: 10.1897/03-544  0.535
2004 Stok JE, Goloshchapov A, Song C, Wheelock CE, Derbel MB, Morisseau C, Hammock BD. Investigation of the role of a second conserved serine in carboxylesterases via site-directed mutagenesis. Archives of Biochemistry and Biophysics. 430: 247-55. PMID 15369824 DOI: 10.1016/J.Abb.2004.06.020  0.547
2004 Dey A, Williams RS, Pollock DM, Stepp DW, Newman JW, Hammock BD, Imig JD. Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria. Obesity Research. 12: 1278-89. PMID 15340111 DOI: 10.1038/Oby.2004.162  0.497
2004 Newman JW, Stok JE, Vidal JD, Corbin CJ, Huang Q, Hammock BD, Conley AJ. Cytochrome p450-dependent lipid metabolism in preovulatory follicles. Endocrinology. 145: 5097-105. PMID 15308618 DOI: 10.1210/En.2004-0710  0.647
2004 Fang X, Weintraub NL, McCaw RB, Hu S, Harmon SD, Rice JB, Hammock BD, Spector AA. Effect of soluble epoxide hydrolase inhibition on epoxyeicosatrienoic acid metabolism in human blood vessels. American Journal of Physiology. Heart and Circulatory Physiology. 287: H2412-20. PMID 15284062 DOI: 10.1152/Ajpheart.00527.2004  0.313
2004 Seubert J, Yang B, Bradbury JA, Graves J, Degraff LM, Gabel S, Gooch R, Foley J, Newman J, Mao L, Rockman HA, Hammock BD, Murphy E, Zeldin DC. Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway. Circulation Research. 95: 506-14. PMID 15256482 DOI: 10.1161/01.Res.0000139436.89654.C8  0.526
2004 Stok JE, Huang H, Jones PD, Wheelock CE, Morisseau C, Hammock BD. Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes. The Journal of Biological Chemistry. 279: 29863-9. PMID 15123619 DOI: 10.1074/Jbc.M403673200  0.554
2004 McAbee RD, Kang KD, Stanich MA, Christiansen JA, Wheelock CE, Inman AD, Hammock BD, Cornel AJ. Pyrethroid tolerance in Culex pipiens pipiens var molestus from Marin County, California. Pest Management Science. 60: 359-68. PMID 15119598 DOI: 10.1002/Ps.799  0.519
2004 Zhao X, Yamamoto T, Newman JW, Kim IH, Watanabe T, Hammock BD, Stewart J, Pollock JS, Pollock DM, Imig JD. Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage. Journal of the American Society of Nephrology : Jasn. 15: 1244-53. PMID 15100364  0.474
2004 Kim IH, Morisseau C, Watanabe T, Hammock BD. Design, synthesis, and biological activity of 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase of increased water solubility. Journal of Medicinal Chemistry. 47: 2110-22. PMID 15056008 DOI: 10.1021/Jm030514J  0.32
2004 Lee HJ, Shan G, Ahn KC, Park EK, Watanabe T, Gee SJ, Hammock BD. Development of an enzyme-linked immunosorbent assay for the pyrethroid cypermethrin. Journal of Agricultural and Food Chemistry. 52: 1039-43. PMID 14995094 DOI: 10.1021/Jf030519P  0.311
2004 Shan G, Huang H, Stoutamire DW, Gee SJ, Leng G, Hammock BD. A sensitive class specific immunoassay for the detection of pyrethroid metabolites in human urine. Chemical Research in Toxicology. 17: 218-25. PMID 14967009 DOI: 10.1021/Tx034220C  0.31
2004 DuTeaux SB, Newman JW, Morisseau C, Fairbairn EA, Jelks K, Hammock BD, Miller MG. Epoxide hydrolases in the rat epididymis: possible roles in xenobiotic and endogenous fatty acid metabolism. Toxicological Sciences : An Official Journal of the Society of Toxicology. 78: 187-95. PMID 14737000 DOI: 10.1093/Toxsci/Kfh066  0.582
2004 Lydy M, Belden J, Wheelock C, Hammock B, Denton D. Challenges in Regulating Pesticide Mixtures Ecology and Society. 9. DOI: 10.5751/Es-00694-090601  0.486
2003 Viswanathan S, Hammock BD, Newman JW, Meerarani P, Toborek M, Hennig B. Involvement of CYP 2C9 in mediating the proinflammatory effects of linoleic acid in vascular endothelial cells. Journal of the American College of Nutrition. 22: 502-10. PMID 14684755 DOI: 10.1080/07315724.2003.10719328  0.563
2003 Taniai K, Inceoglu AB, Yukuhiro K, Hammock BD. Characterization and cDNA cloning of a clofibrate-inducible microsomal epoxide hydrolase in Drosophila melanogaster. European Journal of Biochemistry / Febs. 270: 4696-705. PMID 14622257 DOI: 10.1046/J.1432-1033.2003.03868.X  0.791
2003 Wheelock CE, Nakagawa Y, Akamatsu M, Hammock BD. Use of classical and 3-D QSAR to examine the hydration state of juvenile hormone esterase inhibitors. Bioorganic & Medicinal Chemistry. 11: 5101-16. PMID 14604674 DOI: 10.1016/J.Bmc.2003.08.023  0.569
2003 Kamita SG, Hinton AC, Wheelock CE, Wogulis MD, Wilson DK, Wolf NM, Stok JE, Hock B, Hammock BD. Juvenile hormone (JH) esterase: why are you so JH specific? Insect Biochemistry and Molecular Biology. 33: 1261-73. PMID 14599498 DOI: 10.1016/J.Ibmb.2003.08.004  0.747
2003 Przybyla-Zawislak BD, Srivastava PK, Vazquez-Matias J, Mohrenweiser HW, Maxwell JE, Hammock BD, Bradbury JA, Enayetallah AE, Zeldin DC, Grant DF. Polymorphisms in human soluble epoxide hydrolase. Molecular Pharmacology. 64: 482-90. PMID 12869654 DOI: 10.1124/Mol.64.2.482  0.347
2003 Watanabe T, Morisseau C, Newman JW, Hammock BD. In vitro metabolism of the mammalian soluble epoxide hydrolase inhibitor, 1-cyclohexyl-3-dodecyl-urea. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 846-53. PMID 12814960 DOI: 10.1124/Dmd.31.7.846  0.564
2003 Lee JK, Ahn KC, Stoutamire DW, Gee SJ, Hammock BD. Development of an enzyme-linked immunosorbent assay for the detection of the organophosphorus insecticide acephate. Journal of Agricultural and Food Chemistry. 51: 3695-703. PMID 12797729 DOI: 10.1021/Jf021020I  0.303
2003 Hinton AC, Hammock BD. Juvenile hormone esterase (JHE) from Tenebrio molitor: full-length cDNA sequence, in vitro expression, and characterization of the recombinant protein. Insect Biochemistry and Molecular Biology. 33: 477-87. PMID 12706627 DOI: 10.1016/S0965-1748(03)00010-9  0.699
2003 Wheelock CE, Wheelock AM, Zhang R, Stok JE, Morisseau C, Le Valley SE, Green CE, Hammock BD. Evaluation of alpha-cyanoesters as fluorescent substrates for examining interindividual variation in general and pyrethroid-selective esterases in human liver microsomes. Analytical Biochemistry. 315: 208-22. PMID 12689831 DOI: 10.1016/S0003-2697(03)00002-2  0.546
2003 Hinton AC, Hammock BD. In vitro expression and biochemical characterization of juvenile hormone esterase from Manduca sexta. Insect Biochemistry and Molecular Biology. 33: 317-29. PMID 12609517 DOI: 10.1016/S0965-1748(02)00246-1  0.715
2003 Newman JW, Morisseau C, Harris TR, Hammock BD. The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity. Proceedings of the National Academy of Sciences of the United States of America. 100: 1558-63. PMID 12574510 DOI: 10.1073/Pnas.0437724100  0.56
2003 Denton DL, Wheelock CE, Murray SA, Deanovic LA, Hammock BD, Hinton DE. Joint acute toxicity of esfenvalerate and diazinon to larval fathead minnows (Pimephales promelas). Environmental Toxicology and Chemistry / Setac. 22: 336-41. PMID 12558165 DOI: 10.1002/Etc.5620220214  0.535
2003 Koivunen ME, Morisseau C, Newman JW, Horwath WR, Hammock BD. Purification and characterization of a methylene urea-hydrolyzing enzyme from Rhizobium radiobacter (Agrobacterium tumefaciens) Soil Biology and Biochemistry. 35: 1433-1442. DOI: 10.1016/S0038-0717(03)00237-2  0.558
2003 Székács A, Le HT, Szurdoki F, Hammock BD. Optimization and validation of an enzyme immunoassay for the insect growth regulator fenoxycarb Analytica Chimica Acta. 487: 15-29. DOI: 10.1016/S0003-2670(03)00299-X  0.34
2002 Wheelock CE, Colvin ME, Uemura I, Olmstead MM, Sanborn JR, Nakagawa Y, Jones AD, Hammock BD. Use of ab initio calculations to predict the biological potency of carboxylesterase inhibitors. Journal of Medicinal Chemistry. 45: 5576-93. PMID 12459025 DOI: 10.1021/Jm020072W  0.606
2002 Severson TF, Goodrow MH, Morisseau C, Dowdy DL, Hammock BD. Urea and amide-based inhibitors of the juvenile hormone epoxide hydrolase of the tobacco hornworm (Manduca sexta: Sphingidae). Insect Biochemistry and Molecular Biology. 32: 1741-56. PMID 12429126 DOI: 10.1016/S0965-1748(02)00115-7  0.313
2002 Inceoglu AB, Hayashida Y, Lango J, Ishida AT, Hammock BD. A single charged surface residue modifies the activity of ikitoxin, a beta-type Na+ channel toxin from Parabuthus transvaalicus. European Journal of Biochemistry / Febs. 269: 5369-76. PMID 12423335 DOI: 10.1046/J.1432-1033.2002.03171.X  0.776
2002 Kim KO, Kim YJ, Lee YT, Hammock BD, Lee HS. Development of an enzyme-linked immunosorbent assay for the organophosphorus insecticide bromophos-ethyl. Journal of Agricultural and Food Chemistry. 50: 6675-82. PMID 12405760 DOI: 10.1021/Jf025703+  0.3
2002 Fang X, Weintraub NL, Oltman CL, Stoll LL, Kaduce TL, Harmon S, Dellsperger KC, Morisseau C, Hammock BD, Spector AA. Human coronary endothelial cells convert 14,15-EET to a biologically active chain-shortened epoxide. American Journal of Physiology. Heart and Circulatory Physiology. 283: H2306-14. PMID 12388281 DOI: 10.1152/Ajpheart.00448.2002  0.331
2002 Pei Z, Reske G, Huang Q, Hammock BD, Qi Y, Chejanovsky N. Characterization of the apoptosis suppressor protein P49 from the Spodoptera littoralis nucleopolyhedrovirus. The Journal of Biological Chemistry. 277: 48677-84. PMID 12324475 DOI: 10.1074/Jbc.M208810200  0.436
2002 Newman JW, Watanabe T, Hammock BD. The simultaneous quantification of cytochrome P450 dependent linoleate and arachidonate metabolites in urine by HPLC-MS/MS. Journal of Lipid Research. 43: 1563-78. PMID 12235189 DOI: 10.1194/Jlr.D200018-Jlr200  0.551
2002 Morisseau C, Goodrow MH, Newman JW, Wheelock CE, Dowdy DL, Hammock BD. Structural refinement of inhibitors of urea-based soluble epoxide hydrolases. Biochemical Pharmacology. 63: 1599-608. PMID 12007563 DOI: 10.1016/S0006-2952(02)00952-8  0.684
2002 Wang GY, Michailides TJ, Hammock BD, Lee YM, Bostock RM. Molecular cloning, characterization, and expression of a redox-responsive cutinase from Monilinia fructicola (Wint.) Honey. Fungal Genetics and Biology : Fg & B. 35: 261-76. PMID 11929215 DOI: 10.1006/Fgbi.2001.1320  0.328
2002 Davis BB, Thompson DA, Howard LL, Morisseau C, Hammock BD, Weiss RH. Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation. Proceedings of the National Academy of Sciences of the United States of America. 99: 2222-7. PMID 11842228 DOI: 10.1073/Pnas.261710799  0.352
2002 Szurdoki F, Székács A, Le HM, Hammock BD. Synthesis of haptens and protein conjugates for the development of immunoassays for the insect growth regulator fenoxycarb. Journal of Agricultural and Food Chemistry. 50: 29-40. PMID 11754538 DOI: 10.1021/Jf0107050  0.327
2002 Watanabe T, Hammock BD. Rapid determination of soluble epoxide hydrolase inhibitors in rat hepatic microsomes by high-performance liquid chromatography with electrospray tandem mass spectrometry. Analytical Biochemistry. 299: 227-34. PMID 11730347 DOI: 10.1006/Abio.2001.5423  0.3
2002 Newman JW, Hammock BD. Optimized thiol derivatizing reagent for the mass spectral analysis of disubstituted epoxy fatty acids. Journal of Chromatography. A. 925: 223-40. PMID 11519808 DOI: 10.1016/S0021-9673(01)00998-0  0.538
2002 Taniai K, Inceoglu AB, Hammock BD. Expression efficiency of a scorpion neurotoxin, AaHIT, using baculovirus in insect cells. Applied Entomology and Zoology. 37: 225-232. DOI: 10.1303/Aez.2002.225  0.777
2002 Dedos SG, Szurdoki F, Székács A, Shiotsuki T, Hammock BD, Shimada J, Fugo H. Fenoxycarb levels and their effects on general and juvenile hormone esterase activity in the hemolymph of the silkworm, Bombyx mori Pesticide Biochemistry and Physiology. 73: 174-187. DOI: 10.1016/S0048-3575(02)00106-2  0.31
2002 Zurek G, Gee SJ, Hammock BD. Development of an enzyme immunoassay for linoleic acid diols in urine Analytica Chimica Acta. 466: 247-256. DOI: 10.1016/S0003-2670(02)00589-5  0.341
2001 Wheelock CE, Severson TF, Hammock BD. Synthesis of new carboxylesterase inhibitors and evaluation of potency and water solubility. Chemical Research in Toxicology. 14: 1563-72. PMID 11743738 DOI: 10.1021/Tx015508+  0.585
2001 Shan G, Hammock BD. Development of sensitive esterase assays based on alpha-cyano-containing esters. Analytical Biochemistry. 299: 54-62. PMID 11726184 DOI: 10.1006/Abio.2001.5388  0.318
2001 Hinton AC, Hammock BD. Purification of juvenile hormone esterase and molecular cloning of the cDNA from Manduca sexta. Insect Biochemistry and Molecular Biology. 32: 57-66. PMID 11719069 DOI: 10.1016/S0965-1748(01)00079-0  0.678
2001 Inceoglu AB, Kamita SG, Hinton AC, Huang Q, Severson TF, Kang K, Hammock BD. Recombinant baculoviruses for insect control. Pest Management Science. 57: 981-7. PMID 11695193 DOI: 10.1002/Ps.393  0.768
2001 Inceoglu B, Lango J, Wu J, Hawkins P, Southern J, Hammock BD. Isolation and characterization of a novel type of neurotoxic peptide from the venom of the South African scorpion Parabuthus transvaalicus (Buthidae). European Journal of Biochemistry. 268: 5407-13. PMID 11606203 DOI: 10.1046/J.0014-2956.2001.02479.X  0.309
2001 Watkins SM, Hammock BD, Newman JW, German JB. Individual metabolism should guide agriculture toward foods for improved health and nutrition. The American Journal of Clinical Nutrition. 74: 283-6. PMID 11522549 DOI: 10.1093/Ajcn/74.3.283  0.513
2001 Lee JK, Ahn KC, Park OS, Kang SY, Hammock BD. Development of an ELISA for the detection of the residues of the insecticide imidacloprid in agricultural and environmental samples. Journal of Agricultural and Food Chemistry. 49: 2159-67. PMID 11368571 DOI: 10.1021/Jf001140V  0.305
2001 Huang Q, Deveraux QL, Maeda S, Stennicke HR, Hammock BD, Reed JC. Cloning and characterization of an inhibitor of apoptosis protein (IAP) from Bombyx mori. Biochimica Et Biophysica Acta. 1499: 191-8. PMID 11341966 DOI: 10.1016/S0167-4889(00)00105-1  0.456
2001 Morisseau C, Newman JW, Dowdy DL, Goodrow MH, Hammock BD. Inhibition of microsomal epoxide hydrolases by ureas, amides, and amines. Chemical Research in Toxicology. 14: 409-15. PMID 11304129 DOI: 10.1021/Tx0001732  0.588
2001 Fang X, Kaduce TL, Weintraub NL, Harmon S, Teesch LM, Morisseau C, Thompson DA, Hammock BD, Spector AA. Pathways of epoxyeicosatrienoic acid metabolism in endothelial cells. Implications for the vascular effects of soluble epoxide hydrolase inhibition. The Journal of Biological Chemistry. 276: 14867-74. PMID 11278979 DOI: 10.1074/Jbc.M011761200  0.348
2001 Slim R, Hammock BD, Toborek M, Robertson LW, Newman JW, Morisseau CH, Watkins BA, Saraswathi V, Hennig B. The role of methyl-linoleic acid epoxide and diol metabolites in the amplified toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells. Toxicology and Applied Pharmacology. 171: 184-93. PMID 11243918 DOI: 10.1006/Taap.2001.9131  0.56
2001 Newman JW, Denton DL, Morisseau C, Koger CS, Wheelock CE, Hinton DE, Hammock BD. Evaluation of fish models of soluble epoxide hydrolase inhibition. Environmental Health Perspectives. 109: 61-6. PMID 11171526 DOI: 10.1289/Ehp.0110961  0.66
2001 Nakagawa Y, Wheelock CE, Morisseau C, Goodrow MH, Hammock BG, Hammock BD. Erratum to “3-D QSAR Analysis of Inhibition of Murine Soluble Epoxide Hydrolase (MsEH) by Benzoylureas, Arylureas, and their Analogues” Bioorganic & Medicinal Chemistry. 9: 1941. DOI: 10.1016/S0968-0896(01)00096-7  0.512
2001 Shan G, Leeman WR, Gee SJ, Sanborn JR, Jones AD, Chang DPY, Hammock BD. Highly sensitive dioxin immunoassay and its application to soil and biota samples Analytica Chimica Acta. 444: 169-178. DOI: 10.1016/S0003-2670(01)01159-X  0.348
2001 Taverner PD, Gunning RV, Kolesik P, Bailey PT, Inceoglu AB, Hammock B, Roush RT. Evidence for direct neural toxicity of a "Light" oil on the peripheral nerves of lightbrcown apple moth Pesticide Biochemistry and Physiology. 69: 153-165. DOI: 10.1006/Pest.2000.2527  0.764
2001 Lee Y, Fuxa JR, Inceoglu AB, Alaniz SA, Richter AR, Reilly LM, Hammock BD. Competition between wild-type and recombinant nucleopolyhedroviruses in a greenhouse microcosm Biological Control. 20: 84-93. DOI: 10.1006/Bcon.2000.0876  0.768
2000 Lohse C, Jaeger LL, Staimer N, Sanborn JR, Jones AD, Langó J, Gee SJ, Hammock BD. Development of a class-selective enzyme-linked immunosorbent assay for mercapturic acids in human urine. Journal of Agricultural and Food Chemistry. 48: 5913-23. PMID 11312767 DOI: 10.1021/Jf000621B  0.386
2000 Nakagawa Y, Wheelock CE, Morisseau C, Goodrow MH, Hammock BG, Hammock BD. 3-D QSAR analysis of inhibition of murine soluble epoxide hydrolase (MsEH) by benzoylureas, arylureas, and their analogues. Bioorganic & Medicinal Chemistry. 8: 2663-73. PMID 11092551 DOI: 10.1016/S0968-0896(00)00198-X  0.53
2000 Yu Z, Xu F, Huse LM, Morisseau C, Draper AJ, Newman JW, Parker C, Graham L, Engler MM, Hammock BD, Zeldin DC, Kroetz DL. Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. Circulation Research. 87: 992-8. PMID 11090543 DOI: 10.1161/01.Res.87.11.992  0.553
2000 Wang GY, Michailides TJ, Hammock BD, Lee YM, Bostock RM. Affinity purification and characterization of a cutinase from the fungal plant pathogen Monilinia fructicola (Wint.) honey. Archives of Biochemistry and Biophysics. 382: 31-8. PMID 11051094 DOI: 10.1006/Abbi.2000.1995  0.318
2000 Shiotsuki T, Bonning BC, Hirai M, Kikuchi K, Hammock BD. Characterization and affinity purification of juvenile hormone esterase from Bombyx mori Bioscience, Biotechnology and Biochemistry. 64: 1681-1687. PMID 10993156 DOI: 10.1271/Bbb.64.1681  0.319
2000 Morisseau C, Beetham JK, Pinot F, Debernard S, Newman JW, Hammock BD. Cress and potato soluble epoxide hydrolases: purification, biochemical characterization, and comparison to mammalian enzymes. Archives of Biochemistry and Biophysics. 378: 321-32. PMID 10860549 DOI: 10.1006/Abbi.2000.1810  0.538
2000 Thomas BA, Hinton AC, Moskowitz H, Severson TF, Hammock BD. Isolation of juvenile hormone esterase and its partial cDNA clone from the beetle, Tenebrio molitor. Insect Biochemistry and Molecular Biology. 30: 529-40. PMID 10844245 DOI: 10.1016/S0965-1748(00)00020-5  0.689
2000 Yamada T, Morisseau C, Maxwell JE, Argiriadi MA, Christianson DW, Hammock BD. Biochemical evidence for the involvement of tyrosine in epoxide activation during the catalytic cycle of epoxide hydrolase. The Journal of Biological Chemistry. 275: 23082-8. PMID 10806198 DOI: 10.1074/Jbc.M001464200  0.339
2000 Greene JF, Williamson KC, Newman JW, Morisseau C, Hammock BD. Metabolism of monoepoxides of methyl linoleate: bioactivation and detoxification. Archives of Biochemistry and Biophysics. 376: 420-32. PMID 10775430 DOI: 10.1006/Abbi.2000.1753  0.574
2000 Greene JF, Newman JW, Williamson KC, Hammock BD. Toxicity of epoxy fatty acids and related compounds to cells expressing human soluble epoxide hydrolase. Chemical Research in Toxicology. 13: 217-26. PMID 10775319 DOI: 10.1021/Tx990162C  0.56
2000 Argiriadi MA, Morisseau C, Goodrow MH, Dowdy DL, Hammock BD, Christianson DW. Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation. The Journal of Biological Chemistry. 275: 15265-70. PMID 10747889 DOI: 10.1074/Jbc.M000278200  0.302
2000 Draper AJ, Hammock BD. Identification of CYP2C9 as a human liver microsomal linoleic acid epoxygenase. Archives of Biochemistry and Biophysics. 376: 199-205. PMID 10729206 DOI: 10.1006/Abbi.2000.1705  0.376
2000 Nussbaumer C, Hinton AC, Schopf A, Stradner A, Hammock BD. Isolation and characterization of juvenile hormone esterase from hemolymph of Lymantria dispar by affinity- and by anion-exchange chromatography. Insect Biochemistry and Molecular Biology. 30: 307-14. PMID 10727897 DOI: 10.1016/S0965-1748(00)00002-3  0.691
2000 Greene JF, Zheng J, Grant DF, Hammock BD. Cytotoxicity of 1,2-epoxynaphthalene is correlated with protein binding and in situ glutathione depletion in cytochrome P4501A1 expressing Sf-21 cells. Toxicological Sciences : An Official Journal of the Society of Toxicology. 53: 352-60. PMID 10696783 DOI: 10.1093/Toxsci/53.2.352  0.314
2000 Huang Q, Deveraux QL, Maeda S, Salvesen GS, Stennicke HR, Hammock BD, Reed JC. Evolutionary conservation of apoptosis mechanisms: lepidopteran and baculoviral inhibitor of apoptosis proteins are inhibitors of mammalian caspase-9. Proceedings of the National Academy of Sciences of the United States of America. 97: 1427-32. PMID 10677478 DOI: 10.1073/Pnas.97.4.1427  0.462
2000 Morisseau C, Derbel M, Lane TR, Stoutamire D, Hammock BD. Differential induction of hepatic drug-metabolizing enzymes by fenvaleric acid in male rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 52: 148-53. PMID 10630566 DOI: 10.1093/Toxsci/52.2.148  0.34
2000 Van Meer MMM, Bonning BC, Ward VK, Vlak JM, Hammock BD. Recombinant, catalytically inactive juvenile hormone esterase enhances efficacy of baculovirus insecticides Biological Control. 19: 191-199. DOI: 10.1006/Bcon.2000.0858  0.316
1999 Draper AJ, Hammock BD. Inhibition of soluble and microsomal epoxide hydrolase by zinc and other metals. Toxicological Sciences : An Official Journal of the Society of Toxicology. 52: 26-32. PMID 10568695 DOI: 10.1093/Toxsci/52.1.26  0.334
1999 Shan G, Wengatz I, Stoutamire DW, Gee SJ, Hammock BD. An enzyme-linked immunosorbent assay for the detection of esfenvalerate metabolites in human urine. Chemical Research in Toxicology. 12: 1033-41. PMID 10563828 DOI: 10.1021/Tx990091H  0.302
1999 Shan G, Stoutamire DW, Wengatz I, Gee SJ, Hammock BD. Development of an immunoassay for the pyrethroid insecticide esfenvalerate. Journal of Agricultural and Food Chemistry. 47: 2145-55. PMID 10552511 DOI: 10.1021/Jf981210M  0.31
1999 Buchholz BA, Fultz E, Haack KW, Vogel JS, Gilman SD, Gee SJ, Hammock BD, Hui X, Wester RC, Maibach HI. HPLC-accelerator MS measurement of atrazine metabolites in human urine after dermal exposure. Analytical Chemistry. 71: 3519-25. PMID 10464479 DOI: 10.1021/Ac990152G  0.303
1999 Morisseau C, Goodrow MH, Dowdy D, Zheng J, Greene JF, Sanborn JR, Hammock BD. Potent urea and carbamate inhibitors of soluble epoxide hydrolases. Proceedings of the National Academy of Sciences of the United States of America. 96: 8849-54. PMID 10430859 DOI: 10.1073/Pnas.96.16.8849  0.368
1998 Morisseau C, Du G, Newman JW, Hammock BD. Mechanism of mammalian soluble epoxide hydrolase inhibition by chalcone oxide derivatives. Archives of Biochemistry and Biophysics. 356: 214-28. PMID 9705212 DOI: 10.1006/Abbi.1998.0756  0.577
1998 Moskowitz H, Herrmann R, Jones AD, Hammock BD. A depressant insect-selective toxin analog from the venom of the scorpion Leiurus quinquestriatus hebraeus--purification and structure/function characterization. European Journal of Biochemistry / Febs. 254: 44-9. PMID 9652392 DOI: 10.1046/J.1432-1327.1998.2540044.X  0.371
1998 Nakagawa Y, Sadilek M, Lehmberg E, Herrmann R, Herrmann R, Moskowitz H, Lee YM, Thomas BA, Shimizu R, Kuroda M, Jones AD, Hammock BD. Rapid purification and molecular modeling of AaIT peptides from venom of Androctonus australis. Archives of Insect Biochemistry and Physiology. 38: 53-65. PMID 9627406 DOI: 10.1002/(Sici)1520-6327(1998)38:2<53::Aid-Arch1>3.0.Co;2-W  0.365
1998 Pinot F, Caldas ED, Schmidt C, Gilchrist DG, Jones AD, Winter CK, Hammock BD. Characterization of epoxide hydrolase activity in Alternaria alternata f. sp. lycopersici. Possible involvement in toxin production. Mycopathologia. 140: 51-8. PMID 9608724 DOI: 10.1023/A:1006829330490  0.38
1998 Mitchell AE, Zheng J, Hammock BD, Lo Bello M, Jones AD. Structural and functional consequences of haloenol lactone inactivation of murine and human glutathione S-transferase Biochemistry. 37: 6752-6759. PMID 9578559 DOI: 10.1021/Bi971846R  0.423
1998 Jaeger LL, Jones AD, Hammock BD. Development of an enzyme-linked immunosorbent assay for atrazine mercapturic acid in human urine. Chemical Research in Toxicology. 11: 342-52. PMID 9548805 DOI: 10.1021/Tx9701844  0.429
1998 Sugawara Y, Gee SJ, Sanborn JR, Gilman SD, Hammock BD. Development of a highly sensitive enzyme-linked immunosorbent assay based on polyclonal antibodies for the detection of polychlorinated dibenzo-p-dioxins. Analytical Chemistry. 70: 1092-9. PMID 9530001 DOI: 10.1021/Ac9708203  0.316
1998 Zheng J, Wurz GT, Cadman TB, Degregorio MW, Jones AD, Hammock BD. Haloenol lactone: a new synergist of chemotherapy in vitro. Biochemical and Biophysical Research Communications. 241: 13-7. PMID 9405226 DOI: 10.1006/Bbrc.1997.7762  0.382
1998 Zheng J, Cho M, Jones AD, Hammock BD. Evidence of quinone metabolites of naphthalene covalently bound to sulfur nucleophiles of proteins of murine Clara cells after exposure to naphthalene. Chemical Research in Toxicology. 10: 1008-14. PMID 9305583 DOI: 10.1021/Tx970061J  0.367
1998 Hoover K, Alaniz SA, Yee JL, Rocke DM, Hammock BD, Duffey SS. Dietary Protein and Chlorogenic Acid Effect on Baculoviral Disease of Noctuid (Lepidoptera: Noctuidae) Larvae Environmental Entomology. 27: 1264-1272. DOI: 10.1093/Ee/27.5.1264  0.724
1998 Hoover K, Yee JL, Schultz CM, Rocke DM, Hammock BD, Duffey SS. Journal of Chemical Ecology. 24: 221-252. DOI: 10.1023/A:1022576207506  0.771
1998 Hoover K, Stout MJ, Alaniz SA, Hammock BD, Duffey SS. Journal of Chemical Ecology. 24: 253-271. DOI: 10.1023/A:1022528324344  0.714
1998 Hoover K, Kishida KT, DiGiorgio LA, Workman J, Alaniz SA, Hammock BD, Duffey SS. Journal of Chemical Ecology. 24: 1949-2001. DOI: 10.1023/A:1020777407980  0.448
1998 Hoover K, Kishida KT, Digiorgio LA, Workman J, Alaniz SA, Hammock BD, Duffey SS. Inhibition of baculoviral disease by plant-mediated peroxidase activity and free radical generation Journal of Chemical Ecology. 24: 1949-2001. DOI: 10.1023/A:1020777407980  0.721
1998 Wengatz I, Stoutamire DW, Gee SJ, Hammock BD. Development of an Enzyme-Linked Immunosorbent Assay for the Detection of the Pyrethroid Insecticide Fenpropathrin Journal of Agricultural and Food Chemistry. 46: 2211-2221. DOI: 10.1021/Jf9710847  0.33
1998 Sanborn JR, Gee SJ, Gilman SD, Sugawara Y, Jones AD, Rogers J, Szurdoki F, Stanker LH, Stoutamire DW, Hammock BD. Hapten Synthesis and Antibody Development for Polychlorinated Dibenzo-p-dioxin Immunoassays Journal of Agricultural and Food Chemistry. 46: 2407-2416. DOI: 10.1021/Jf970716M  0.374
1997 McCutchen BF, Hoover K, Preisler HK, Betana MD, Herrmann R, Robertson JL, Hammock BD. Interactions of recombinant and wild-type baculoviruses with classical insecticides and pyrethroid-resistant tobacco budworm (Lepidoptera: Noctuidae). Journal of Economic Entomology. 90: 1170-80. PMID 9374595 DOI: 10.1093/Jee/90.5.1170  0.513
1997 Nakagawa Y, Lee YM, Lehmberg E, Herrmann R, Herrmann R, Moskowitz H, Jones AD, Hammock BD. Anti-insect toxin 5 (AaIT5) from Androctonus australis. European Journal of Biochemistry / Febs. 246: 496-501. PMID 9208943 DOI: 10.1111/J.1432-1033.1997.T01-1-00496.X  0.37
1997 Müller F, Arand M, Frank H, Seidel A, Hinz W, Winkler L, Hänel K, Blée E, Beetham JK, Hammock BD, Oesch F. Visualization of a covalent intermediate between microsomal epoxide hydrolase, but not cholesterol epoxide hydrolase, and their substrates. European Journal of Biochemistry. 245: 490-6. PMID 9151984 DOI: 10.1111/J.1432-1033.1997.00490.X  0.34
1997 Hoover K, Schultz CM, Lane SS, Bonning BC, Hammock BD, Duffey SS. Effects of diet-age and streptomycin on virulence of Autographa californica M nucleopolyhedrovirus against the tobacco budworm Journal of Invertebrate Pathology. 69: 46-50. PMID 9028927 DOI: 10.1006/Jipa.1996.4620  0.756
1997 Huang TL, Hammock BD. Solubilization of Mouse Liver Microsomal Carboxylesterases Pharmacy and Pharmacology Communications. 3: 605-608. DOI: 10.1111/J.2042-7158.1997.Tb00506.X  0.32
1997 Schütz S, Wengatz I, Goodrow MH, Gee SJ, Hummel HE, Hammock BD. Development of an Enzyme-Linked Immunosorbent Assay for Azadirachtins† Journal of Agricultural and Food Chemistry. 45: 2363-2368. DOI: 10.1021/Jf960688S  0.315
1997 Kido H, Goodrow MH, Griffeth V, Lucas AD, Gee SJ, Hammock BD. Development of an Enzyme-Linked Immunosorbent Assay for the Detection of Hydroxytriazines Journal of Agricultural and Food Chemistry. 45: 414-424. DOI: 10.1021/Jf960164S  0.326
1997 Stauffer C, Shiotsuki T, Chan W, Hammock BD. Characterization of the esterase isozymes ofIps typographus (coleoptera, scolytidae) Archives of Insect Biochemistry and Physiology. 34: 203-221. DOI: 10.1002/(Sici)1520-6327(1997)34:2<203::Aid-Arch6>3.0.Co;2-X  0.318
1996 Borhan B, Hammock B, Seifert J, Wilson BW. Methyl and phenyl esters and thioesters of carboxylic acids as surrogate substrates for microassay of proteinase K esterase activity. Analytical and Bioanalytical Chemistry. 354: 490-2. PMID 15048439 DOI: 10.1007/S0021663540490  0.551
1996 Huang TL, Shiotsuki T, Uematsu T, Borhan B, Li QX, Hammock BD. Structure-activity relationships for substrates and inhibitors of mammalian liver microsomal carboxylesterases. Pharmaceutical Research. 13: 1495-500. PMID 8899840 DOI: 10.1023/A:1016071311190  0.626
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