| Year |
Citation |
Score |
| 2012 |
May EL. 3,4-Dihydro-1,3-oxazines from Dcycloheexylcarbodiimide. Journal of Medicinal Chemistry. 10: 505-6. PMID 22185171 DOI: 10.1021/Jm00315A055 |
0.343 |
|
| 2008 |
Metcalf MD, Aceto MD, Harris LS, Woods JH, Traynor JR, Coop A, May EL. The influence of esters and carboxylic acids as the N-substituent of opioids. Part 1: Benzomorphans. Bioorganic & Medicinal Chemistry. 16: 869-73. PMID 17962026 DOI: 10.1016/j.bmc.2007.10.030 |
0.585 |
|
| 2007 |
Hiebel AC, Lee YS, Bilsky E, Giuvelis D, Deschamps JR, Parrish DA, Aceto MD, May EL, Harris LS, Coop A, Dersch CM, Partilla JS, Rothman RB, Cheng K, Jacobson AE, et al. Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an exceedingly potent antinociceptive in the enantiomeric C9-substituted 5-(3-hydroxyphenyl)-N-phenylethylmorphan series. Journal of Medicinal Chemistry. 50: 3765-76. PMID 17625813 DOI: 10.1021/Jm061325E |
0.623 |
|
| 2007 |
Cheng K, Kim IJ, Lee MJ, Adah SA, Raymond TJ, Bilsky EJ, Aceto MD, May EL, Harris LS, Coop A, Dersch CM, Rothman RB, Jacobson AE, Rice KC. Opioid ligands with mixed properties from substituted enantiomeric N-phenethyl-5-phenylmorphans. Synthesis of a micro-agonist delta-antagonist and delta-inverse agonists. Organic & Biomolecular Chemistry. 5: 1177-90. PMID 17406716 DOI: 10.1039/B618875C |
0.639 |
|
| 2004 |
Thompson CM, Wojno H, Greiner E, May EL, Rice KC, Selley DE. Activation of G-proteins by morphine and codeine congeners: insights to the relevance of O- and N-demethylated metabolites at mu- and delta-opioid receptors. The Journal of Pharmacology and Experimental Therapeutics. 308: 547-54. PMID 14600248 DOI: 10.1124/Jpet.103.058602 |
0.524 |
|
| 2003 |
May EL, Coop A, Woods JH, Aceto MD, Bowman ER, Harris LS, Traynor JR. N-(trifluoromethyl)benzyl substituted N-normetazocines and N-norketobemidones. Bioorganic & Medicinal Chemistry. 11: 31-3. PMID 12467704 DOI: 10.1016/S0968-0896(02)00435-2 |
0.561 |
|
| 1998 |
May EL, Jacobson AE, Mattson MV, Coop A, Aceto MD, Bowman ER, Traynor JR, Woods JH, Harris LS. Synthesis, in vitro, and in vivo activity of N-p-substituted-benzyl- (- )- and (+)-N-normetazocines, (-)- and (+)-N-normorphinans, N- norketobemidones, and (-)-N-nor-4,5-epoxymorphinans Medicinal Chemistry Research. 8: 311-321. |
0.492 |
|
| 1993 |
Glassco W, Suchocki J, George C, Martin BR, May EL. Synthesis, optical resolution, absolute configuration, and preliminary pharmacology of (+)- and (-)-cis-2,3,3a,4,5,9b-hexahydro-1-methyl-1H- pyrrolo-[3,2-h]isoquinoline, a structural analog of nicotine. Journal of Medicinal Chemistry. 36: 3381-5. PMID 8230128 DOI: 10.1021/Jm00074A019 |
0.304 |
|
| 1991 |
Suchocki JA, May EL, Martin TJ, George C, Martin BR. Synthesis of 2-exo- and 2-endo-mecamylamine analogues. Structure-activity relationships for nicotinic antagonism in the central nervous system. Journal of Medicinal Chemistry. 34: 1003-10. PMID 2002445 DOI: 10.1021/Jm00107A019 |
0.384 |
|
| 1991 |
Iorio MA, Frigeni V, Bowman ER, Harris LS, May EL, Aceto MD. Common stereospecificity of opioid and dopamine systems for N-butyrophenone prodine-like compounds. Journal of Medicinal Chemistry. 34: 194-7. PMID 1671414 DOI: 10.1021/Jm00105A029 |
0.301 |
|
| 1987 |
Awaya H, May EL, Aceto MD, Harris LS, Silverton JV, Rice KC, Mattson MV, Jacobson AE. Hexahydro-1H-1-pyrindines from acid rearrangement of 9-alkylidene-5-(m-methoxyphenyl)-2-methylmorphans. A new structural type of narcotic antagonists. Journal of Medicinal Chemistry. 30: 947-50. PMID 3033248 DOI: 10.1021/Jm00388A037 |
0.431 |
|
| 1986 |
Lessor RA, Bajwa BS, Rice KC, Jacobson AE, Streaty RA, Klee WA, Smith CB, Aceto MD, May EL, Harris LS. Probes for narcotic receptor mediated phenomena. 13. Potential irreversible narcotic antagonist-based ligands derived from 6,14-endo-ethenotetrahydronororipavine with 7-(methoxyfumaroyl)amino, (bromoacetyl)amino, or isothiocyanate electrophiles: chemistry, biochemistry, and pharmacology. Journal of Medicinal Chemistry. 29: 2136-41. PMID 3023609 DOI: 10.1021/Jm00161A002 |
0.468 |
|
| 1984 |
Awaya H, May EL, Aceto MD, Merz H, Rogers ME, Harris LS. Racemic and optically active 2,9-dimethyl-5-(m-hydroxyphenyl)morphans and pharmacological comparison with the 9-demethyl homologues. Journal of Medicinal Chemistry. 27: 536-9. PMID 6708055 DOI: 10.1021/Jm00370A019 |
0.355 |
|
| 1984 |
Awaya H, May EL, Jacobson AE, Aceto MD. 9 alpha- and 9 beta-Hydroxyphenylmorphans. Journal of Pharmaceutical Sciences. 73: 1867-8. PMID 6543226 DOI: 10.1002/Jps.2600731261 |
0.346 |
|
| 1982 |
Brady KT, Balster RL, May EL. Stereoisomers of N-allylnormetazocine: phencyclidine-like behavioral effects in squirrel monkeys and rats. Science (New York, N.Y.). 215: 178-80. PMID 6274022 DOI: 10.1126/Science.6274022 |
0.315 |
|
| 1978 |
Uwaydah IM, May EL, Harris LS. SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF SOME N-ALKYL-SUBSTITUTED 9α-ETHYL-2′-HYDROXY-5-METHYL-6,7-BENZOMORPHANS Cheminform. 9. DOI: 10.1002/Chin.197816256 |
0.385 |
|
| 1977 |
May EL, Jacobson AE. Chemistry and pharmacology of homologs of 6 acetyl and 3,6 diacetylmorphine Journal of Pharmaceutical Sciences. 66: 285-286. PMID 402470 DOI: 10.1002/Jps.2600660242 |
0.317 |
|
| 1977 |
Uwaydah IM, May EL, Harris LS. Synthesis and pharmacological activity of some N-alkyl-substituted 9alpha-ethyl-2'-hydroxy-5-methyl-6,7-benzomorphans. Journal of Medicinal Chemistry. 20: 1374-7. PMID 21291 DOI: 10.1021/Jm00221A004 |
0.409 |
|
| 1976 |
Wilson RS, May EL, Martin BR, Dewey WL. 9 Nor 9 hydroxyhexahydrocannabinols. Synthesis, some behavioral and analgesic properties, and comparison with the tetrahydrocannabinols Journal of Medicinal Chemistry. 19: 1165-1167. PMID 978681 DOI: 10.1002/Chin.197652236 |
0.326 |
|
| 1976 |
Inoue H, May EL. Synthesis and pharmacology of 2,9α-dimethyl-2′-hydroxy-6,7-benzomorphan Journal of Medicinal Chemistry. 19: 259-262. PMID 814236 DOI: 10.1021/Jm00224A012 |
0.329 |
|
| 1975 |
Rice KC, Jacobson AE, May EL. Synthesis and analgesic activities of 2,5-dimethyl-2′-hydroxy-9α- and -β-propyl-6,7-benzomorphans Journal of Medicinal Chemistry. 18: 854-857. PMID 1159706 DOI: 10.1021/Jm00242A022 |
0.518 |
|
| 1975 |
Rogers ME, Ong HH, May EL, Klee WA. Analgetic activity and in vitro binding constants of some N-alkyl-3-benzazocines. Journal of Medicinal Chemistry. 18: 1036-8. PMID 1159686 DOI: 10.1002/Chin.197603231 |
0.351 |
|
| 1975 |
Wilson RS, May EL. Analgesic properties of the tetrahydrocannabinols, their metabolites, and analogs Journal of Medicinal Chemistry. 18: 700-703. PMID 1151992 DOI: 10.1002/Chin.197540232 |
0.333 |
|
| 1975 |
Inoue H, Thyagarajan G, May EL. Transformations in the pyridine series. An improved preparation of 3-methyl-4-phenylpyridine Journal of Heterocyclic Chemistry. 12: 709-710. DOI: 10.1002/Jhet.5570120419 |
0.323 |
|
| 1975 |
RICE KC, JACOBSON AE, MAY EL. ChemInform Abstract: SYNTHESIS AND ANALGESIC ACTIVITIES OF 2,5-DIMETHYL-2′-HYDROXY-9ALPHA- AND -BETA-PROPYL-6,7-BENZOMORPHANS Chemischer Informationsdienst. 6: no-no. DOI: 10.1002/Chin.197549332 |
0.449 |
|
| 1974 |
Ong HH, O-Ishi T, May EL. Phenylmorphan agonists-antagonists. Journal of Medicinal Chemistry. 17: 133-4. PMID 4202213 DOI: 10.1002/Chin.197420345 |
0.315 |
|
| 1973 |
Oh-ishi T, May EL. N-alkylnorketobemidones with strong agonist and weak antagonist Properties Journal of Medicinal Chemistry. 16: 1376-1378. PMID 4203140 DOI: 10.1002/Chin.197417295 |
0.335 |
|
| 1970 |
Takeda M, May EL. Acyl derivatives of 5-hydroxy-6,7-benzomorphans. Prodine congeners Journal of Medicinal Chemistry. 13: 1223-1224. PMID 4991394 DOI: 10.1021/Jm00300A048 |
0.364 |
|
| 1970 |
Sargent LJ, May EL. Agonists-antagonists derived from desomorphine and metopon Journal of Medicinal Chemistry. 13: 1061-1063. PMID 4098039 DOI: 10.1021/Jm00300A009 |
0.359 |
|
| 1965 |
Chignell CF, Ager JH, May EL. Structures related to morphine. XXVIII. Alternative syntheses of α- and α-2,9-dimethyl-2′-hydroxy-5-propyl-6,7-benzomorphan Journal of Medicinal Chemistry. 8: 235-238. PMID 14332668 DOI: 10.1021/Jm00326A020 |
0.353 |
|
| 1965 |
Chignell CF, May EL. Structures related to morphine. XXIX. Further experiments on the stereo-controlled reduction of 9-methylene-6,7-benzomorphans Journal of Medicinal Chemistry. 8: 385-386. PMID 14323152 DOI: 10.1021/Jm00327A022 |
0.352 |
|
| 1965 |
Joshi BC, May EL. Structures related to morphine. XXXII. α- and β-2,9-dimethyl-5-propyl-6,7-benzo-morphan from 3-methyl-4-propylpyridine Journal of Medicinal Chemistry. 8: 696-697. PMID 5869909 DOI: 10.1021/Jm00329A031 |
0.354 |
|
| 1965 |
Joshi BC, Chignell CF, May EL. Structures related to morphine. XXX. N-hexyl- and 5-butyl-, -amyl-, and -hexyl-6,7-benzomorphans Journal of Medicinal Chemistry. 8: 694-696. DOI: 10.1021/Jm00329A030 |
0.398 |
|
| 1965 |
Jacobson AE, May EL. Structures Related to Morphine. XXXI.12'-Substituted Benzomorphans Journal of Medicinal Chemistry. 8: 563-566. DOI: 10.1021/Jm00329A003 |
0.413 |
|
| 1965 |
Jacobson AE, May EL. Structures related to morphine. XXXI. 2′-substituted benzomorphans Journal of Medicinal Chemistry. 8: 563-566. |
0.316 |
|
| 1964 |
JACOBSON AE, MAY EL. STRUCTURES RELATED TO MORPHINE. XXVII. ALPHA-AND BETA-5,9-DIETHYL-2-METHYL-6,7-BENZOMORPHANS Journal of Medicinal Chemistry. 7: 409-412. PMID 14221116 DOI: 10.1021/Jm00334A004 |
0.345 |
|
| 1963 |
Ager JH, Fullerton SE, May EL. Structures related to morphine. XXV. 5-Propyl- and 5,9-dipropyl-6,7-benzomorphans and a pharmacologic summary Journal of Medicinal Chemistry. 6: 322-325. PMID 14185995 DOI: 10.1021/Jm00339A025 |
0.39 |
|
| 1963 |
Ager JH, Fullerton SE, Fry EM, May EL. Structure related to morphine. XXVI. Cyclization experiments with 2-benzyl-1,3,4-trialkyl-1,2,5,6-tetrahydropyridines. Improved yields of β-5,9-dialkyl-6,7-benzomorphans Journal of Organic Chemistry. 28: 2470-2472. DOI: 10.1021/Jo01044A522 |
0.362 |
|
| 1962 |
Kugita H, Saito S, May EL. Structures related to morphine. XXII.1 A benzomorphan congener of meperidine Journal of Medicinal and Pharmaceutical Chemistry. 5: 357-361. PMID 14051911 DOI: 10.1021/Jm01237A013 |
0.38 |
|
| 1962 |
Fullerton SE, Ager JH, May EL. Structures related to morphine. XXIV. Further application of the Stevens rearrangement in the synthesis of diastereoisomeric 6,7-benzomorphans from 3-ethyl-4-methyl- and 4-ethyl-3-methylpyridines Journal of Organic Chemistry. 27: 2554-2557. DOI: 10.1021/Jo01054A059 |
0.425 |
|
| 1962 |
Fullerton SE, May EL, Becker ED. Structures Related to Morphine. XXIII.1 Stereochemistry of 5,9-Dialkyl-6,7-benzomorphans Journal of Organic Chemistry. 27: 2144-2147. DOI: 10.1021/Jo01053A058 |
0.391 |
|
| 1962 |
Saito S, May EL. Structures related to morphine. XXI. An alternative synthesis of diastereoisomeric 2′-hydroxy-2,5,9-trimethyl-6,7-benzomorphans Journal of Organic Chemistry. 27: 1087-1089. DOI: 10.1021/Jo01050A540 |
0.433 |
|
| 1962 |
Saito S, May EL. Structures related to morphine. XX. Stevens reaction in the synthesis of 5-ethyl-2′-hydroxy-2-methyl-(or phenethyl)-6,7-benzomorphan Journal of Organic Chemistry. 27: 948-951. DOI: 10.1021/Jo01050A063 |
0.427 |
|
| 1962 |
Ager JH, May EL. Structures related to morphine. XIX. Benzomorphans from 3,4-diethylpyridine Journal of Organic Chemistry. 27: 245-247. DOI: 10.1021/Jo01048A059 |
0.378 |
|
| 1961 |
Gordon M, Lafferty JJ, Tedeschi DH, Eddy NB, May EL. A new potent analgetic antagonist Nature. 192: 1089. PMID 13900480 DOI: 10.1038/1921089A0 |
0.372 |
|
| 1961 |
Fry E, May E. Notes- The Stevens Rearrangement in the Benzomorphan Synthesis The Journal of Organic Chemistry. 26: 2592-2594. DOI: 10.1021/Jo01351A640 |
0.309 |
|
| 1961 |
Saito S, May EL. Structures related to morphine. XVIII. Stereochemical control of addition of hydrogen and methylmetallo reagents to 5-ethyl-2-methyl-9-oxo-6,7-benzomorphan Journal of Organic Chemistry. 26: 4536-4540. DOI: 10.1021/Jo01069A081 |
0.376 |
|
| 1961 |
Kugita H, May EL. Structures related to morphine. XVI. 1 Stereochcmical control of addition of hydrogen to 9-oxobenzomorphans Journal of Organic Chemistry. 26: 1954-1957. DOI: 10.1021/Jo01065A064 |
0.325 |
|
| 1961 |
May EL. Structures related to morphine. XVII. Further stereochemical studies with 9-oxobenzomorphans Journal of Organic Chemistry®. 26: 1621-1624. DOI: 10.1021/Jo01064A077 |
0.38 |
|
| 1961 |
May EL, Kugita H. Structures related to morphine. XV. Stereochemical control of methyl-metallo additions to 9-oxobenzomorphans Journal of Organic Chemistry. 26: 188-193. DOI: 10.1021/Jo01060A044 |
0.386 |
|
| 1960 |
Murphy JG, Harrison Ager J, May EL. Structures related to morphine. XIV. 2′-Hydroxy-5-methyl-2-phenethyl-6,7-benzomorphan, the 9-demethyl analog of NIH 7519 (phenazocine) from 3,4-dihydro-7-methoxy-2(1H)naphthalenone Journal of Organic Chemistry. 25: 1386-1388. DOI: 10.1021/Jo01078A023 |
0.405 |
|
| 1960 |
Ager JH, May EL. Structures related to morphine. XIII. 2-Alkyl-2′-hydroxy-5,9-dimethyl-6,7-benzomorphans and a more direct synthesis of 2-phenethyl compound (NIH 7519) Journal of Organic Chemistry. 25: 984-986. DOI: 10.1021/Jo01076A030 |
0.452 |
|
| 1959 |
May E, Ager J. Correction - Structures Related to Morphine. XI. The Journal of Organic Chemistry. 24: 2074-2074. DOI: 10.1021/Jo01094A654 |
0.369 |
|
| 1959 |
May EL, Eddy NB. Structures related to morphine. XII. (±)-2′-Hydroxy-5,9-dimethyl-2-phenethyl-6,7-benzomorphan (NIH 7519) and its optical forms Journal of Organic Chemistry. 24: 1435-1437. DOI: 10.1021/Jo01092A012 |
0.33 |
|
| 1959 |
May EL, Ager JH. Structures related to morphine. XI. Analogs and a diastereoisomer of 2′-hydroxy-2,5,9-trimethyl-6,7-benzomorphan Journal of Organic Chemistry. 24: 1432-1435. DOI: 10.1021/Jo01092A011 |
0.42 |
|
| 1958 |
Small L, Eddy N, Ager J, May E. Notes: An Improved Synthesis of N-Phenethylnormorphine and Analogs The Journal of Organic Chemistry. 23: 1387-1388. DOI: 10.1021/Jo01103A615 |
0.308 |
|
| 1958 |
May EL. Structures related to morphine. X.1 A position isomer of (±)-3-hydroxy-N-methylmorphinan (racemorphan) The Journal of Organic Chemistry. 23: 947-949. DOI: 10.1021/Jo01101A002 |
0.336 |
|
| 1957 |
EDDY NB, MURPHY JG, MAY EL. Structures Related to Morphine. IX.*1Extension of the Grewe Morphinan Synthesis in the Benzomorphan Series and Pharmacology of Some Benzomorphans The Journal of Organic Chemistry. 22: 1370-1372. DOI: 10.1021/Jo01362A018 |
0.434 |
|
| 1957 |
May EL, Fry EM. Structures related to morphine. VIII. Further syntheses in the benzomorphan series Journal of Organic Chemistry. 22: 1370-1372. DOI: 10.1021/Jo01362A017 |
0.42 |
|
| 1957 |
May E. Notes - Structures Related to Morphine. VII. Piperidine Derivatives and Examples of Failure in Knoevenagel Reaction Journal of Organic Chemistry. 22: 593-594. DOI: 10.1021/Jo01356A623 |
0.363 |
|
| 1956 |
May EL. Structures related to morphine. VI. N-phenylethyl derivatives of some phenyl- and benz-morphans Journal of Organic Chemistry. 21: 899-901. DOI: 10.1021/Jo01114A021 |
0.431 |
|
| 1956 |
May EL. Structures related to morphine. V. Azabicyclodecanes derived from 2-(m-methoxyphenyl)cyclohexanone Journal of Organic Chemistry. 21: 223-225. DOI: 10.1021/Jo01108A019 |
0.354 |
|
| 1955 |
May EL, Murphy JG. Structures related to morphine. IV. m-substituted phenylcyclohexane derivatives Journal of Organic Chemistry. 20: 1197-1201. DOI: 10.1021/Jo01126A008 |
0.394 |
|
| 1955 |
May EL, Murphy JG. Structures related to morphine. III. Synthesis of an analog of N-methylmorphinan Journal of Organic Chemistry. 20: 257-263. DOI: 10.1021/Jo01120A017 |
0.428 |
|
| 1954 |
Perrine TD, May EL. Synthesis of 6-dimethylamino-4,4-diphenylheptane and other compounds related to methadone Journal of Organic Chemistry. 19: 773-779. DOI: 10.1021/Jo01370A012 |
0.352 |
|
| 1954 |
May EL, Murphy JG. Structures related to morphine. II. An isomer of N-methylmorphinan Journal of Organic Chemistry. 19: 618-622. DOI: 10.1021/Jo01369A021 |
0.379 |
|
| 1954 |
Murphy JG, May EL. Structures related to morphine. I. 2-(2-dimethylaminoethyl)-2-phenylcyclohexanone and derivatives Journal of Organic Chemistry. 19: 615-617. DOI: 10.1021/Jo01369A020 |
0.407 |
|
| 1952 |
May EL, Eddy NB. The isomethadols and their acetyl derivatives Journal of Organic Chemistry. 17: 1210-1215. DOI: 10.1021/Jo50009A005 |
0.31 |
|
| 1951 |
May EL, Mosettig E. Studies in the anthracene series. VII. Reduction of highly hindered ketones with lithium aluminum hydride Journal of the American Chemical Society. 73: 1301-1302. DOI: 10.1021/Ja01147A129 |
0.314 |
|
| 1949 |
May EL, Mosettig E. Cyclitol derivatives. I. Derivatives of rac.-epi-inosose Journal of Organic Chemistry. 14: 1137-1140. DOI: 10.1021/Jo01158A027 |
0.31 |
|
| 1948 |
Latham HG, May EL, Mosettig E. Studies in the anthracene series. VI. Derivatives of 1,2,3,4-tetrahydroanthracene Journal of the American Chemical Society. 70: 1079-1081. PMID 18909177 DOI: 10.1021/Ja01183A061 |
0.318 |
|
| 1948 |
May EL, Mosettig E. Studies in the anthracene series. IV. Meso-substituted 9,10-dihydroanthracene derivatives Journal of the American Chemical Society. 70: 688-691. PMID 18907774 DOI: 10.1021/Ja01182A077 |
0.357 |
|
| 1948 |
May EL, Mosettig E. Studies in the anthracene series. III. Amino ketones derived from 9-acetylanthracene Journal of the American Chemical Society. 70: 686-688. PMID 18907773 DOI: 10.1021/Ja01182A076 |
0.337 |
|
| 1947 |
MAY EL, MOSETTIG E. Studies in the anthracene series; alkyl ketones derived from Journal of the American Chemical Society. 69: 3036. PMID 18919708 DOI: 10.1021/Ja01204A030 |
0.363 |
|
| 1947 |
May EL, Mosettig E. Biguanide and thiourea derivatives of quinoline Journal of Organic Chemistry. 12: 869-871. DOI: 10.1021/Jo01170A018 |
0.336 |
|
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